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	Fusion Gene Summary
	Fusion Gene Sample Information
	Fusion ORF Analysis
	Fusion Amino Acid Sequences
	Fusion Protein Functional Features
	Fusion Protein-Protein Interaction
	Related drugs with this fusion protein
	Related disease with this fusion protein

Fusion Protein:N4BP2L2-RUNX1

Fusion Protein Summary

Fusion gene summary

Fusion partner gene information	Fusion gene name: N4BP2L2-RUNX1
	FusionPDB ID: 56916
	FusionGDB2.0 ID: 56916
		Hgene	Tgene
	Gene symbol	N4BP2L2	RUNX1
	Gene ID	10443	861
	Gene name	NEDD4 binding protein 2 like 2	RUNX family transcription factor 1
	Synonyms	92M18.3\|CG005\|CG016\|PFAAP5	AML1\|AML1-EVI-1\|AMLCR1\|CBF2alpha\|CBFA2\|EVI-1\|PEBP2aB\|PEBP2alpha
	Cytomap	13q13.1	21q22.12
	Type of gene	protein-coding	protein-coding
	Description	NEDD4-binding protein 2-like 2phosphonoformate immuno-associated protein 5protein from BRCA2 region	runt-related transcription factor 1AML1-EVI-1 fusion proteinPEA2-alpha BPEBP2-alpha BSL3-3 enhancer factor 1 alpha B subunitSL3/AKV core-binding factor alpha B subunitacute myeloid leukemia 1 proteincore-binding factor, runt domain, alpha subunit 2
	Modification date	20200320	20200322
	UniProtAcc	Q92802	Q06455
Ensembl transtripts involved in fusion gene	ENST ids	ENST00000357505, ENST00000399396, ENST00000446957, ENST00000504114, ENST00000267068, ENST00000380121,	ENST00000358356, ENST00000486278, ENST00000494829, ENST00000300305, ENST00000325074, ENST00000344691, ENST00000399240, ENST00000437180,
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)	* DoF score	13 X 15 X 5=975	36 X 59 X 13=27612
	# samples	17	63
	** MAII score	log2(17/975*10)=-2.51986747249927 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(63/27612*10)=-5.45379975055797 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)	PubMed: N4BP2L2 [Title/Abstract] AND RUNX1 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)	N4BP2L2(33091993)-RUNX1(36171759), # samples:1 N4BP2L2(33091994)-RUNX1(36171759), # samples:1
Anticipated loss of major functional domain due to fusion event.	N4BP2L2-RUNX1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. N4BP2L2-RUNX1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. N4BP2L2-RUNX1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. N4BP2L2-RUNX1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. N4BP2L2-RUNX1 seems lost the major protein functional domain in Tgene partner, which is a CGC due to the frame-shifted ORF. N4BP2L2-RUNX1 seems lost the major protein functional domain in Tgene partner, which is a transcription factor due to the frame-shifted ORF. N4BP2L2-RUNX1 seems lost the major protein functional domain in Tgene partner, which is a tumor suppressor due to the frame-shifted ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Tgene	RUNX1	GO:0030097	hemopoiesis	21873977
Tgene	RUNX1	GO:0045893	positive regulation of transcription, DNA-templated	10207087\|14970218
Tgene	RUNX1	GO:0045944	positive regulation of transcription by RNA polymerase II	9199349\|10207087\|14970218\|21873977

Fusion gene breakpoints across N4BP2L2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across RUNX1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

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Fusion Gene Sample Information

Fusion gene information from FusionGDB2.0.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	STAD	TCGA-BR-A4QI-01A	N4BP2L2	chr13	33091994	-	RUNX1	chr21	36171759	-
ChimerDB4	STAD	TCGA-BR-A4QI	N4BP2L2	chr13	33091993	-	RUNX1	chr21	36171759	-

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Fusion ORF Analysis

Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000399396	N4BP2L2	chr13	33091993	-	ENST00000344691	RUNX1	chr21	36171759	-	5404	432	10	1422	470
ENST00000399396	N4BP2L2	chr13	33091993	-	ENST00000325074	RUNX1	chr21	36171759	-	5404	432	10	1422	470
ENST00000399396	N4BP2L2	chr13	33091993	-	ENST00000437180	RUNX1	chr21	36171759	-	5404	432	10	1422	470
ENST00000399396	N4BP2L2	chr13	33091993	-	ENST00000300305	RUNX1	chr21	36171759	-	5404	432	10	1422	470
ENST00000399396	N4BP2L2	chr13	33091993	-	ENST00000399240	RUNX1	chr21	36171759	-	1419	432	10	1416	469
ENST00000399396	N4BP2L2	chr13	33091994	-	ENST00000344691	RUNX1	chr21	36171759	-	5404	432	10	1422	470
ENST00000399396	N4BP2L2	chr13	33091994	-	ENST00000325074	RUNX1	chr21	36171759	-	5404	432	10	1422	470
ENST00000399396	N4BP2L2	chr13	33091994	-	ENST00000437180	RUNX1	chr21	36171759	-	5404	432	10	1422	470
ENST00000399396	N4BP2L2	chr13	33091994	-	ENST00000300305	RUNX1	chr21	36171759	-	5404	432	10	1422	470
ENST00000399396	N4BP2L2	chr13	33091994	-	ENST00000399240	RUNX1	chr21	36171759	-	1419	432	10	1416	469

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000399396	ENST00000344691	N4BP2L2	chr13	33091993	-	RUNX1	chr21	36171759	-	0.009260801	0.9907392
ENST00000399396	ENST00000325074	N4BP2L2	chr13	33091993	-	RUNX1	chr21	36171759	-	0.009260801	0.9907392
ENST00000399396	ENST00000437180	N4BP2L2	chr13	33091993	-	RUNX1	chr21	36171759	-	0.009260801	0.9907392
ENST00000399396	ENST00000300305	N4BP2L2	chr13	33091993	-	RUNX1	chr21	36171759	-	0.009260801	0.9907392
ENST00000399396	ENST00000399240	N4BP2L2	chr13	33091993	-	RUNX1	chr21	36171759	-	0.021353686	0.97864634
ENST00000399396	ENST00000344691	N4BP2L2	chr13	33091994	-	RUNX1	chr21	36171759	-	0.009260801	0.9907392
ENST00000399396	ENST00000325074	N4BP2L2	chr13	33091994	-	RUNX1	chr21	36171759	-	0.009260801	0.9907392
ENST00000399396	ENST00000437180	N4BP2L2	chr13	33091994	-	RUNX1	chr21	36171759	-	0.009260801	0.9907392
ENST00000399396	ENST00000300305	N4BP2L2	chr13	33091994	-	RUNX1	chr21	36171759	-	0.009260801	0.9907392
ENST00000399396	ENST00000399240	N4BP2L2	chr13	33091994	-	RUNX1	chr21	36171759	-	0.021353686	0.97864634

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Fusion Amino Acid Sequences

For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>56916_56916_1_N4BP2L2-RUNX1_N4BP2L2_chr13_33091993_ENST00000399396_RUNX1_chr21_36171759_ENST00000300305_length(amino acids)=470AA_BP=135
MRTEMSYGEIEEFCLVRIVMALCSALMTIFTIKMGTAKQAIDQGRSPVIIDNTNIQAWEMKPYVEVAIGKGYRVEFHEPETWWKFDPEEL
EKRNKHGVSRKKIAQMLDRYEYQMSISIVMNSVEPSHKSTQRPPPPQGRQRYKADPTIPTVVLRSVLPIPGIHCLSFCAPSNAHFTWTCQ
RHDNPLCRTFQSTLNGTRPDSVQRPAPVPRAALHLRPPHALSRRLHLLPDAGHLGHRHRHVGHGLGHALPHLPAAALPRLVASAGRPVPS
QLALLPPVLRRLGRLLPVLHGGRRALAAAHPAALHQRLHRLRAAQPQPPEPERRGGGRGQPQQLPHQHGALRAPGGGRVEALLRRQAWPG
WAPRAAAFASGRAGLLFATSPPGSRALGPATVLGPRAPDGQDLAVGQARAASCAQKPTPPPSAGAPALAEVSEATHLEGVRRPQHPGDAL

--------------------------------------------------------------

>56916_56916_2_N4BP2L2-RUNX1_N4BP2L2_chr13_33091993_ENST00000399396_RUNX1_chr21_36171759_ENST00000325074_length(amino acids)=470AA_BP=135
MRTEMSYGEIEEFCLVRIVMALCSALMTIFTIKMGTAKQAIDQGRSPVIIDNTNIQAWEMKPYVEVAIGKGYRVEFHEPETWWKFDPEEL
EKRNKHGVSRKKIAQMLDRYEYQMSISIVMNSVEPSHKSTQRPPPPQGRQRYKADPTIPTVVLRSVLPIPGIHCLSFCAPSNAHFTWTCQ
RHDNPLCRTFQSTLNGTRPDSVQRPAPVPRAALHLRPPHALSRRLHLLPDAGHLGHRHRHVGHGLGHALPHLPAAALPRLVASAGRPVPS
QLALLPPVLRRLGRLLPVLHGGRRALAAAHPAALHQRLHRLRAAQPQPPEPERRGGGRGQPQQLPHQHGALRAPGGGRVEALLRRQAWPG
WAPRAAAFASGRAGLLFATSPPGSRALGPATVLGPRAPDGQDLAVGQARAASCAQKPTPPPSAGAPALAEVSEATHLEGVRRPQHPGDAL

--------------------------------------------------------------

>56916_56916_3_N4BP2L2-RUNX1_N4BP2L2_chr13_33091993_ENST00000399396_RUNX1_chr21_36171759_ENST00000344691_length(amino acids)=470AA_BP=135
MRTEMSYGEIEEFCLVRIVMALCSALMTIFTIKMGTAKQAIDQGRSPVIIDNTNIQAWEMKPYVEVAIGKGYRVEFHEPETWWKFDPEEL
EKRNKHGVSRKKIAQMLDRYEYQMSISIVMNSVEPSHKSTQRPPPPQGRQRYKADPTIPTVVLRSVLPIPGIHCLSFCAPSNAHFTWTCQ
RHDNPLCRTFQSTLNGTRPDSVQRPAPVPRAALHLRPPHALSRRLHLLPDAGHLGHRHRHVGHGLGHALPHLPAAALPRLVASAGRPVPS
QLALLPPVLRRLGRLLPVLHGGRRALAAAHPAALHQRLHRLRAAQPQPPEPERRGGGRGQPQQLPHQHGALRAPGGGRVEALLRRQAWPG
WAPRAAAFASGRAGLLFATSPPGSRALGPATVLGPRAPDGQDLAVGQARAASCAQKPTPPPSAGAPALAEVSEATHLEGVRRPQHPGDAL

--------------------------------------------------------------

>56916_56916_4_N4BP2L2-RUNX1_N4BP2L2_chr13_33091993_ENST00000399396_RUNX1_chr21_36171759_ENST00000399240_length(amino acids)=469AA_BP=135
MRTEMSYGEIEEFCLVRIVMALCSALMTIFTIKMGTAKQAIDQGRSPVIIDNTNIQAWEMKPYVEVAIGKGYRVEFHEPETWWKFDPEEL
EKRNKHGVSRKKIAQMLDRYEYQMSISIVMNSVEPSHKSTQRPPPPQGRQRYKADPTIPTVVLRSVLPIPGIHCLSFCAPSNAHFTWTCQ
RHDNPLCRTFQSTLNGTRPDSVQRPAPVPRAALHLRPPHALSRRLHLLPDAGHLGHRHRHVGHGLGHALPHLPAAALPRLVASAGRPVPS
QLALLPPVLRRLGRLLPVLHGGRRALAAAHPAALHQRLHRLRAAQPQPPEPERRGGGRGQPQQLPHQHGALRAPGGGRVEALLRRQAWPG
WAPRAAAFASGRAGLLFATSPPGSRALGPATVLGPRAPDGQDLAVGQARAASCAQKPTPPPSAGAPALAEVSEATHLEGVRRPQHPGDAL

--------------------------------------------------------------

>56916_56916_5_N4BP2L2-RUNX1_N4BP2L2_chr13_33091993_ENST00000399396_RUNX1_chr21_36171759_ENST00000437180_length(amino acids)=470AA_BP=135
MRTEMSYGEIEEFCLVRIVMALCSALMTIFTIKMGTAKQAIDQGRSPVIIDNTNIQAWEMKPYVEVAIGKGYRVEFHEPETWWKFDPEEL
EKRNKHGVSRKKIAQMLDRYEYQMSISIVMNSVEPSHKSTQRPPPPQGRQRYKADPTIPTVVLRSVLPIPGIHCLSFCAPSNAHFTWTCQ
RHDNPLCRTFQSTLNGTRPDSVQRPAPVPRAALHLRPPHALSRRLHLLPDAGHLGHRHRHVGHGLGHALPHLPAAALPRLVASAGRPVPS
QLALLPPVLRRLGRLLPVLHGGRRALAAAHPAALHQRLHRLRAAQPQPPEPERRGGGRGQPQQLPHQHGALRAPGGGRVEALLRRQAWPG
WAPRAAAFASGRAGLLFATSPPGSRALGPATVLGPRAPDGQDLAVGQARAASCAQKPTPPPSAGAPALAEVSEATHLEGVRRPQHPGDAL

--------------------------------------------------------------

>56916_56916_6_N4BP2L2-RUNX1_N4BP2L2_chr13_33091994_ENST00000399396_RUNX1_chr21_36171759_ENST00000300305_length(amino acids)=470AA_BP=135
MRTEMSYGEIEEFCLVRIVMALCSALMTIFTIKMGTAKQAIDQGRSPVIIDNTNIQAWEMKPYVEVAIGKGYRVEFHEPETWWKFDPEEL
EKRNKHGVSRKKIAQMLDRYEYQMSISIVMNSVEPSHKSTQRPPPPQGRQRYKADPTIPTVVLRSVLPIPGIHCLSFCAPSNAHFTWTCQ
RHDNPLCRTFQSTLNGTRPDSVQRPAPVPRAALHLRPPHALSRRLHLLPDAGHLGHRHRHVGHGLGHALPHLPAAALPRLVASAGRPVPS
QLALLPPVLRRLGRLLPVLHGGRRALAAAHPAALHQRLHRLRAAQPQPPEPERRGGGRGQPQQLPHQHGALRAPGGGRVEALLRRQAWPG
WAPRAAAFASGRAGLLFATSPPGSRALGPATVLGPRAPDGQDLAVGQARAASCAQKPTPPPSAGAPALAEVSEATHLEGVRRPQHPGDAL

--------------------------------------------------------------

>56916_56916_7_N4BP2L2-RUNX1_N4BP2L2_chr13_33091994_ENST00000399396_RUNX1_chr21_36171759_ENST00000325074_length(amino acids)=470AA_BP=135
MRTEMSYGEIEEFCLVRIVMALCSALMTIFTIKMGTAKQAIDQGRSPVIIDNTNIQAWEMKPYVEVAIGKGYRVEFHEPETWWKFDPEEL
EKRNKHGVSRKKIAQMLDRYEYQMSISIVMNSVEPSHKSTQRPPPPQGRQRYKADPTIPTVVLRSVLPIPGIHCLSFCAPSNAHFTWTCQ
RHDNPLCRTFQSTLNGTRPDSVQRPAPVPRAALHLRPPHALSRRLHLLPDAGHLGHRHRHVGHGLGHALPHLPAAALPRLVASAGRPVPS
QLALLPPVLRRLGRLLPVLHGGRRALAAAHPAALHQRLHRLRAAQPQPPEPERRGGGRGQPQQLPHQHGALRAPGGGRVEALLRRQAWPG
WAPRAAAFASGRAGLLFATSPPGSRALGPATVLGPRAPDGQDLAVGQARAASCAQKPTPPPSAGAPALAEVSEATHLEGVRRPQHPGDAL

--------------------------------------------------------------

>56916_56916_8_N4BP2L2-RUNX1_N4BP2L2_chr13_33091994_ENST00000399396_RUNX1_chr21_36171759_ENST00000344691_length(amino acids)=470AA_BP=135
MRTEMSYGEIEEFCLVRIVMALCSALMTIFTIKMGTAKQAIDQGRSPVIIDNTNIQAWEMKPYVEVAIGKGYRVEFHEPETWWKFDPEEL
EKRNKHGVSRKKIAQMLDRYEYQMSISIVMNSVEPSHKSTQRPPPPQGRQRYKADPTIPTVVLRSVLPIPGIHCLSFCAPSNAHFTWTCQ
RHDNPLCRTFQSTLNGTRPDSVQRPAPVPRAALHLRPPHALSRRLHLLPDAGHLGHRHRHVGHGLGHALPHLPAAALPRLVASAGRPVPS
QLALLPPVLRRLGRLLPVLHGGRRALAAAHPAALHQRLHRLRAAQPQPPEPERRGGGRGQPQQLPHQHGALRAPGGGRVEALLRRQAWPG
WAPRAAAFASGRAGLLFATSPPGSRALGPATVLGPRAPDGQDLAVGQARAASCAQKPTPPPSAGAPALAEVSEATHLEGVRRPQHPGDAL

--------------------------------------------------------------

>56916_56916_9_N4BP2L2-RUNX1_N4BP2L2_chr13_33091994_ENST00000399396_RUNX1_chr21_36171759_ENST00000399240_length(amino acids)=469AA_BP=135
MRTEMSYGEIEEFCLVRIVMALCSALMTIFTIKMGTAKQAIDQGRSPVIIDNTNIQAWEMKPYVEVAIGKGYRVEFHEPETWWKFDPEEL
EKRNKHGVSRKKIAQMLDRYEYQMSISIVMNSVEPSHKSTQRPPPPQGRQRYKADPTIPTVVLRSVLPIPGIHCLSFCAPSNAHFTWTCQ
RHDNPLCRTFQSTLNGTRPDSVQRPAPVPRAALHLRPPHALSRRLHLLPDAGHLGHRHRHVGHGLGHALPHLPAAALPRLVASAGRPVPS
QLALLPPVLRRLGRLLPVLHGGRRALAAAHPAALHQRLHRLRAAQPQPPEPERRGGGRGQPQQLPHQHGALRAPGGGRVEALLRRQAWPG
WAPRAAAFASGRAGLLFATSPPGSRALGPATVLGPRAPDGQDLAVGQARAASCAQKPTPPPSAGAPALAEVSEATHLEGVRRPQHPGDAL

--------------------------------------------------------------

>56916_56916_10_N4BP2L2-RUNX1_N4BP2L2_chr13_33091994_ENST00000399396_RUNX1_chr21_36171759_ENST00000437180_length(amino acids)=470AA_BP=135
MRTEMSYGEIEEFCLVRIVMALCSALMTIFTIKMGTAKQAIDQGRSPVIIDNTNIQAWEMKPYVEVAIGKGYRVEFHEPETWWKFDPEEL
EKRNKHGVSRKKIAQMLDRYEYQMSISIVMNSVEPSHKSTQRPPPPQGRQRYKADPTIPTVVLRSVLPIPGIHCLSFCAPSNAHFTWTCQ
RHDNPLCRTFQSTLNGTRPDSVQRPAPVPRAALHLRPPHALSRRLHLLPDAGHLGHRHRHVGHGLGHALPHLPAAALPRLVASAGRPVPS
QLALLPPVLRRLGRLLPVLHGGRRALAAAHPAALHQRLHRLRAAQPQPPEPERRGGGRGQPQQLPHQHGALRAPGGGRVEALLRRQAWPG
WAPRAAAFASGRAGLLFATSPPGSRALGPATVLGPRAPDGQDLAVGQARAASCAQKPTPPPSAGAPALAEVSEATHLEGVRRPQHPGDAL

--------------------------------------------------------------

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Fusion Protein Functional Features

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr13:33091993/chr21:36171759)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
N4BP2L2 Q92802	RUNX1 Q06455
	FUNCTION: Transcriptional corepressor which facilitates transcriptional repression via its association with DNA-binding transcription factors and recruitment of other corepressors and histone-modifying enzymes (PubMed:12559562, PubMed:15203199, PubMed:10688654). Can repress the expression of MMP7 in a ZBTB33-dependent manner (PubMed:23251453). Can repress transactivation mediated by TCF12 (PubMed:16803958). Acts as a negative regulator of adipogenesis (By similarity). The AML1-MTG8/ETO fusion protein frequently found in leukemic cells is involved in leukemogenesis and contributes to hematopoietic stem/progenitor cell self-renewal (PubMed:23812588). {ECO:0000250\|UniProtKB:Q61909, ECO:0000269\|PubMed:10688654, ECO:0000269\|PubMed:10973986, ECO:0000269\|PubMed:16803958, ECO:0000269\|PubMed:23251453, ECO:0000269\|PubMed:23812588, ECO:0000303\|PubMed:12559562, ECO:0000303\|PubMed:15203199}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
* Minus value of BPloci means that the break pointn is located before the CDS.

- Retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

N4BP2L2

chr13:33091993

chr21:36171759

ENST00000446957

162_197

565.6666666666666

237.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

N4BP2L2

chr13:33091994

chr21:36171759

ENST00000446957

162_197

565.6666666666666

237.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

N4BP2L2

chr13:33091993

chr21:36171759

ENST00000446957

558_561

565.6666666666666

237.0

Compositional bias

Note=Poly-Pro

Hgene

N4BP2L2

chr13:33091994

chr21:36171759

ENST00000446957

558_561

565.6666666666666

237.0

Compositional bias

Note=Poly-Pro

Tgene

RUNX1

chr13:33091993

chr21:36171759

ENST00000358356

187_453

251.0

Compositional bias

Note=Pro/Ser/Thr-rich

Tgene

RUNX1

chr13:33091994

chr21:36171759

ENST00000358356

187_453

251.0

Compositional bias

Note=Pro/Ser/Thr-rich

Tgene

RUNX1

chr13:33091993

chr21:36171759

ENST00000358356

50_178

251.0

Domain

Runt

Tgene

RUNX1

chr13:33091994

chr21:36171759

ENST00000358356

50_178

251.0

Domain

Runt

- Not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

N4BP2L2

chr13:33091993

chr21:36171759

ENST00000267068

162_197

584.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

N4BP2L2

chr13:33091993

chr21:36171759

ENST00000399396

162_197

136.66666666666666

813.3333333333334

Coiled coil

Ontology_term=ECO:0000255

Hgene

N4BP2L2

chr13:33091994

chr21:36171759

ENST00000267068

162_197

584.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

N4BP2L2

chr13:33091994

chr21:36171759

ENST00000399396

162_197

136.66666666666666

813.3333333333334

Coiled coil

Ontology_term=ECO:0000255

Hgene

N4BP2L2

chr13:33091993

chr21:36171759

ENST00000267068

558_561

584.0

Compositional bias

Note=Poly-Pro

Hgene

N4BP2L2

chr13:33091993

chr21:36171759

ENST00000399396

558_561

136.66666666666666

813.3333333333334

Compositional bias

Note=Poly-Pro

Hgene

N4BP2L2

chr13:33091994

chr21:36171759

ENST00000267068

558_561

584.0

Compositional bias

Note=Poly-Pro

Hgene

N4BP2L2

chr13:33091994

chr21:36171759

ENST00000399396

558_561

136.66666666666666

813.3333333333334

Compositional bias

Note=Poly-Pro

Tgene

RUNX1

chr13:33091993

chr21:36171759

ENST00000300305

187_453

268.3333333333333

481.0

Compositional bias

Note=Pro/Ser/Thr-rich

Tgene

RUNX1

chr13:33091993

chr21:36171759

ENST00000325074

187_453

256.3333333333333

469.0

Compositional bias

Note=Pro/Ser/Thr-rich

Tgene

RUNX1

chr13:33091993

chr21:36171759

ENST00000344691

187_453

241.33333333333334

454.0

Compositional bias

Note=Pro/Ser/Thr-rich

Tgene

RUNX1

chr13:33091993

chr21:36171759

ENST00000437180

187_453

268.3333333333333

481.0

Compositional bias

Note=Pro/Ser/Thr-rich

Tgene

RUNX1

chr13:33091994

chr21:36171759

ENST00000300305

187_453

268.3333333333333

481.0

Compositional bias

Note=Pro/Ser/Thr-rich

Tgene

RUNX1

chr13:33091994

chr21:36171759

ENST00000325074

187_453

256.3333333333333

469.0

Compositional bias

Note=Pro/Ser/Thr-rich

Tgene

RUNX1

chr13:33091994

chr21:36171759

ENST00000344691

187_453

241.33333333333334

454.0

Compositional bias

Note=Pro/Ser/Thr-rich

Tgene

RUNX1

chr13:33091994

chr21:36171759

ENST00000437180

187_453

268.3333333333333

481.0

Compositional bias

Note=Pro/Ser/Thr-rich

Tgene

RUNX1

chr13:33091993

chr21:36171759

ENST00000300305

50_178

268.3333333333333

481.0

Domain

Runt

Tgene

RUNX1

chr13:33091993

chr21:36171759

ENST00000325074

50_178

256.3333333333333

469.0

Domain

Runt

Tgene

RUNX1

chr13:33091993

chr21:36171759

ENST00000344691

50_178

241.33333333333334

454.0

Domain

Runt

Tgene

RUNX1

chr13:33091993

chr21:36171759

ENST00000437180

50_178

268.3333333333333

481.0

Domain

Runt

Tgene

RUNX1

chr13:33091994

chr21:36171759

ENST00000300305

50_178

268.3333333333333

481.0

Domain

Runt

Tgene

RUNX1

chr13:33091994

chr21:36171759

ENST00000325074

50_178

256.3333333333333

469.0

Domain

Runt

Tgene

RUNX1

chr13:33091994

chr21:36171759

ENST00000344691

50_178

241.33333333333334

454.0

Domain

Runt

Tgene

RUNX1

chr13:33091994

chr21:36171759

ENST00000437180

50_178

268.3333333333333

481.0

Domain

Runt

Top

Fusion Protein-Protein Interaction

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)

Gene

PPI interactors

RUNX1

SUV39H1, KAT6B, CBFB, AES, PAX5, YAP1, JUN, FOS, SMAD3, SMAD1, SMAD2, SMAD5, VDR, ELF4, ELF2, CEBPB, TLE1, CBFA2T2, TRAF6, FHL2, MYOD1, HIPK2, EP300, HDAC1, HDAC3, KAT6A, tat, TCF12, TCF3, RUNX1T1, NCOR1, SIAH1, UBE2L6, RUNX1, PML, RARA, HDAC2, SIN3A, NR4A2, TRIM33, STUB1, Vdr, SMARCA4, SMARCB1, SMARCC1, CDK1, TAL1, COPRS, KMT2A, RBM14, SPEN, DNMT1, ELAVL1, CBFA2T3, PRMT1, HLA-DMA, CREBBP, UXT, CTBP2, NOTCH1, MYC, NCOR2, FOXP3, SOX2, CTBP1, HDAC11, RAG1, SPI1, ELF1, Cep72, CDK6, vif, KLF6, NFATC1, NFATC2, ZNF131, BRCA1, CDK9, FANCD2, Cbfb, CTNNB1, WWP1, RNF38, RNF44, DTX2, TRIM5, UHRF2, DZIP3, NEDD4, NKX2-1, HIF1A, ACTB, ARID1A, ARID3A, ASH2L, ACTL6A, BRD9, C2orf44, CCNK, CDC16, CDKN2AIP, CLTC, NELFB, CPSF3, CPSF6, CSTF2, CSTF2T, CTPS1, DDX1, DDX17, DDX21, DDX3X, DDX41, DDX5, DHX15, DHX36, DHX9, DPF2, EEF1A1, EEF1A2, EWSR1, EZR, FAF1, FERMT3, FIP1L1, FUBP1, FUS, GATAD2A, GATAD2B, GMPS, HIC2, HNRNPH1, HNRNPM, HNRNPR, HNRNPU, HSPA1A, HSPA2, HSPA5, HSPA8, HSPA9, IGF2BP1, INTS10, INTS9, KHSRP, KIF2B, LARP7, LCP1, LMNA, LMNB1, LRRC40, LRWD1, MED1, MED12, MED16, MED17, MED26, MEN1, MLLT1, MTA2, NDC80, NOP56, NONO, NUP85, ORC2, PABPC1, PABPC4, PAXIP1, PRMT5, PSIP1, PSPC1, RAD18, RANGAP1, RARS, RBBP5, RBM39, RPA1, RPAP2, SF1, SF3B2, SF3B3, SFPQ, SMARCC2, SMARCD1, SNRNP70, SNRPD1, SNX9, U2SURP, SRP68, SYNCRIP, TAF15, TFRC, TKT, TRAP1, TRIM25, TUBA1B, TUBB2A, UBP1, USP39, WDR76, XRCC6, XRN2, ZNF326, DMBT1, DNAJA3, DNAJB11, DPYSL2, DYNLL1, EIF3A, EIF3G, EIF4A2, EMG1, DCPS, IKZF3, IKZF1, MAD2L2, KIAA1429, Hipk2, HIST1H4A, ORF3b, MAPK1, TEAD2, SNRPC, BAG3, TEKT5, BAG4, NFKBID, VPS37C, FAM222B, OLIG3, GCC1, HGS, TEAD4, FBXO17, CIC, GSK3A, ATG7, FBXW12, RUNX2, FOXF2, NAAA, GPR55, BTF3,

Protein-protein interactors based on sequence similarity (STRING)

Gene	STRING network
N4BP2L2
RUNX1

- Retained interactions in fusion protein (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost interactions due to fusion (protein functional feature from UniProt).

Partner	Gene	Hbp	Tbp	ENST	Strand	BPexon	TotalExon	Protein feature loci	*BPloci	TotalLen	Interaction lost with
Tgene	RUNX1	chr13:33091993	chr21:36171759	ENST00000300305		5	8	135_143	268.3333333333333	481.0	DNA
Tgene	RUNX1	chr13:33091993	chr21:36171759	ENST00000300305		5	8	168_177	268.3333333333333	481.0	DNA
Tgene	RUNX1	chr13:33091993	chr21:36171759	ENST00000300305		5	8	80_84	268.3333333333333	481.0	DNA
Tgene	RUNX1	chr13:33091993	chr21:36171759	ENST00000325074		4	7	135_143	256.3333333333333	469.0	DNA
Tgene	RUNX1	chr13:33091993	chr21:36171759	ENST00000325074		4	7	168_177	256.3333333333333	469.0	DNA
Tgene	RUNX1	chr13:33091993	chr21:36171759	ENST00000325074		4	7	80_84	256.3333333333333	469.0	DNA
Tgene	RUNX1	chr13:33091993	chr21:36171759	ENST00000344691		3	6	135_143	241.33333333333334	454.0	DNA
Tgene	RUNX1	chr13:33091993	chr21:36171759	ENST00000344691		3	6	168_177	241.33333333333334	454.0	DNA
Tgene	RUNX1	chr13:33091993	chr21:36171759	ENST00000344691		3	6	80_84	241.33333333333334	454.0	DNA
Tgene	RUNX1	chr13:33091993	chr21:36171759	ENST00000437180		6	9	135_143	268.3333333333333	481.0	DNA
Tgene	RUNX1	chr13:33091993	chr21:36171759	ENST00000437180		6	9	168_177	268.3333333333333	481.0	DNA
Tgene	RUNX1	chr13:33091993	chr21:36171759	ENST00000437180		6	9	80_84	268.3333333333333	481.0	DNA
Tgene	RUNX1	chr13:33091994	chr21:36171759	ENST00000300305		5	8	135_143	268.3333333333333	481.0	DNA
Tgene	RUNX1	chr13:33091994	chr21:36171759	ENST00000300305		5	8	168_177	268.3333333333333	481.0	DNA
Tgene	RUNX1	chr13:33091994	chr21:36171759	ENST00000300305		5	8	80_84	268.3333333333333	481.0	DNA
Tgene	RUNX1	chr13:33091994	chr21:36171759	ENST00000325074		4	7	135_143	256.3333333333333	469.0	DNA
Tgene	RUNX1	chr13:33091994	chr21:36171759	ENST00000325074		4	7	168_177	256.3333333333333	469.0	DNA
Tgene	RUNX1	chr13:33091994	chr21:36171759	ENST00000325074		4	7	80_84	256.3333333333333	469.0	DNA
Tgene	RUNX1	chr13:33091994	chr21:36171759	ENST00000344691		3	6	135_143	241.33333333333334	454.0	DNA
Tgene	RUNX1	chr13:33091994	chr21:36171759	ENST00000344691		3	6	168_177	241.33333333333334	454.0	DNA
Tgene	RUNX1	chr13:33091994	chr21:36171759	ENST00000344691		3	6	80_84	241.33333333333334	454.0	DNA
Tgene	RUNX1	chr13:33091994	chr21:36171759	ENST00000437180		6	9	135_143	268.3333333333333	481.0	DNA
Tgene	RUNX1	chr13:33091994	chr21:36171759	ENST00000437180		6	9	168_177	268.3333333333333	481.0	DNA
Tgene	RUNX1	chr13:33091994	chr21:36171759	ENST00000437180		6	9	80_84	268.3333333333333	481.0	DNA

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Related Drugs to N4BP2L2-RUNX1

Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Drug

Source

PMID

Top

Related Diseases to N4BP2L2-RUNX1

Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Disease

Source

PMID

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner	Gene	Disease ID	Disease name	# pubmeds	Source
Tgene	RUNX1	C1832388	Platelet Disorder, Familial, with Associated Myeloid Malignancy	11	CLINGEN;CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT
Tgene	RUNX1	C0023467	Leukemia, Myelocytic, Acute	4	CGI;CTD_human;GENOMICS_ENGLAND
Tgene	RUNX1	C0026998	Acute Myeloid Leukemia, M1	3	CTD_human
Tgene	RUNX1	C1879321	Acute Myeloid Leukemia (AML-M2)	3	CTD_human
Tgene	RUNX1	C0023485	Precursor B-Cell Lymphoblastic Leukemia-Lymphoma	2	CTD_human
Tgene	RUNX1	C0003873	Rheumatoid Arthritis	1	CTD_human
Tgene	RUNX1	C0006413	Burkitt Lymphoma	1	ORPHANET
Tgene	RUNX1	C0017636	Glioblastoma	1	CTD_human
Tgene	RUNX1	C0023452	Childhood Acute Lymphoblastic Leukemia	1	CTD_human
Tgene	RUNX1	C0023453	L2 Acute Lymphoblastic Leukemia	1	CTD_human
Tgene	RUNX1	C0023473	Myeloid Leukemia, Chronic	1	ORPHANET
Tgene	RUNX1	C0033578	Prostatic Neoplasms	1	CTD_human
Tgene	RUNX1	C0040034	Thrombocytopenia	1	GENOMICS_ENGLAND
Tgene	RUNX1	C0334588	Giant Cell Glioblastoma	1	CTD_human
Tgene	RUNX1	C0349639	Juvenile Myelomonocytic Leukemia	1	CTD_human
Tgene	RUNX1	C0376358	Malignant neoplasm of prostate	1	CTD_human
Tgene	RUNX1	C1292769	Precursor B-cell lymphoblastic leukemia	1	ORPHANET
Tgene	RUNX1	C1621958	Glioblastoma Multiforme	1	CTD_human
Tgene	RUNX1	C1961102	Precursor Cell Lymphoblastic Leukemia Lymphoma	1	CTD_human
Tgene	RUNX1	C2713368	Hematopoetic Myelodysplasia	1	CTD_human
Tgene	RUNX1	C3463824	MYELODYSPLASTIC SYNDROME	1	CTD_human