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	Fusion Gene Summary
	Fusion Gene Sample Information
	Fusion ORF Analysis
	Fusion Amino Acid Sequences
	Fusion Protein Functional Features
	Fusion Protein-Protein Interaction
	Related drugs with this fusion protein
	Related disease with this fusion protein

Fusion Protein:NCOR2-CTDP1

Fusion Protein Summary

Fusion gene summary

Fusion partner gene information	Fusion gene name: NCOR2-CTDP1
	FusionPDB ID: 57862
	FusionGDB2.0 ID: 57862
		Hgene	Tgene
	Gene symbol	NCOR2	CTDP1
	Gene ID	9612	9150
	Gene name	nuclear receptor corepressor 2	CTD phosphatase subunit 1
	Synonyms	CTG26\|N-CoR2\|SMAP270\|SMRT\|SMRTE\|SMRTE-tau\|TNRC14\|TRAC\|TRAC-1\|TRAC1	CCFDN\|FCP1
	Cytomap	12q24.31	18q23
	Type of gene	protein-coding	protein-coding
	Description	nuclear receptor corepressor 2CTG repeat protein 26T3 receptor-associating factorsilencing mediator for retinoid and thyroid hormone receptorsthyroid-, retinoic-acid-receptor-associated corepressor	RNA polymerase II subunit A C-terminal domain phosphataseCTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) phosphatase, subunit 1CTD of POLR2A, phosphatase of, subunit 1TFIIF-associating CTD phosphatase 1serine phosphatase FCP1atranscri
	Modification date	20200313	20200313
	UniProtAcc	Q9Y618	Q9Y5B0
Ensembl transtripts involved in fusion gene	ENST ids	ENST00000356219, ENST00000397355, ENST00000404121, ENST00000404621, ENST00000405201, ENST00000429285,	ENST00000587623, ENST00000075430, ENST00000299543,
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)	* DoF score	35 X 38 X 19=25270	8 X 5 X 6=240
	# samples	51	9
	** MAII score	log2(51/25270*10)=-5.63078460697328 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(9/240*10)=-1.41503749927884 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)	PubMed: NCOR2 [Title/Abstract] AND CTDP1 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)	NCOR2(124882664)-CTDP1(77455224), # samples:1
Anticipated loss of major functional domain due to fusion event.	NCOR2-CTDP1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. NCOR2-CTDP1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. NCOR2-CTDP1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. NCOR2-CTDP1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. NCOR2-CTDP1 seems lost the major protein functional domain in Hgene partner, which is a cell metabolism gene due to the frame-shifted ORF. NCOR2-CTDP1 seems lost the major protein functional domain in Hgene partner, which is a CGC due to the frame-shifted ORF. NCOR2-CTDP1 seems lost the major protein functional domain in Hgene partner, which is a epigenetic factor due to the frame-shifted ORF. NCOR2-CTDP1 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF. NCOR2-CTDP1 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Tgene	CTDP1	GO:0006470	protein dephosphorylation	9765293\|22692537
Tgene	CTDP1	GO:0043923	positive regulation by host of viral transcription	15723517

Fusion gene breakpoints across NCOR2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across CTDP1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

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Fusion Gene Sample Information

Fusion gene information from FusionGDB2.0.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	STAD	TCGA-CG-5722	NCOR2	chr12	124882664	-	CTDP1	chr18	77455224	+

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Fusion ORF Analysis

Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000404621	NCOR2	chr12	124882664	-	ENST00000299543	CTDP1	chr18	77455224	+	5321	2029	1994	4600	868
ENST00000404621	NCOR2	chr12	124882664	-	ENST00000075430	CTDP1	chr18	77455224	+	5151	2029	1994	4318	774
ENST00000404121	NCOR2	chr12	124882664	-	ENST00000299543	CTDP1	chr18	77455224	+	5324	2032	1997	4603	868
ENST00000404121	NCOR2	chr12	124882664	-	ENST00000075430	CTDP1	chr18	77455224	+	5154	2032	1997	4321	774
ENST00000356219	NCOR2	chr12	124882664	-	ENST00000299543	CTDP1	chr18	77455224	+	5324	2032	1997	4603	868
ENST00000356219	NCOR2	chr12	124882664	-	ENST00000075430	CTDP1	chr18	77455224	+	5154	2032	1997	4321	774
ENST00000397355	NCOR2	chr12	124882664	-	ENST00000299543	CTDP1	chr18	77455224	+	5324	2032	1997	4603	868
ENST00000397355	NCOR2	chr12	124882664	-	ENST00000075430	CTDP1	chr18	77455224	+	5154	2032	1997	4321	774
ENST00000429285	NCOR2	chr12	124882664	-	ENST00000299543	CTDP1	chr18	77455224	+	5321	2029	1994	4600	868
ENST00000429285	NCOR2	chr12	124882664	-	ENST00000075430	CTDP1	chr18	77455224	+	5151	2029	1994	4318	774

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000404621	ENST00000299543	NCOR2	chr12	124882664	-	CTDP1	chr18	77455224	+	0.025414445	0.9745856
ENST00000404621	ENST00000075430	NCOR2	chr12	124882664	-	CTDP1	chr18	77455224	+	0.032283675	0.9677163
ENST00000404121	ENST00000299543	NCOR2	chr12	124882664	-	CTDP1	chr18	77455224	+	0.025986392	0.97401357
ENST00000404121	ENST00000075430	NCOR2	chr12	124882664	-	CTDP1	chr18	77455224	+	0.03303877	0.9669612
ENST00000356219	ENST00000299543	NCOR2	chr12	124882664	-	CTDP1	chr18	77455224	+	0.025986392	0.97401357
ENST00000356219	ENST00000075430	NCOR2	chr12	124882664	-	CTDP1	chr18	77455224	+	0.03303877	0.9669612
ENST00000397355	ENST00000299543	NCOR2	chr12	124882664	-	CTDP1	chr18	77455224	+	0.025986392	0.97401357
ENST00000397355	ENST00000075430	NCOR2	chr12	124882664	-	CTDP1	chr18	77455224	+	0.03303877	0.9669612
ENST00000429285	ENST00000299543	NCOR2	chr12	124882664	-	CTDP1	chr18	77455224	+	0.025414445	0.9745856
ENST00000429285	ENST00000075430	NCOR2	chr12	124882664	-	CTDP1	chr18	77455224	+	0.032283675	0.9677163

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Fusion Amino Acid Sequences

For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>57862_57862_1_NCOR2-CTDP1_NCOR2_chr12_124882664_ENST00000356219_CTDP1_chr18_77455224_ENST00000075430_length(amino acids)=774AA_BP=11
MDRRRNGNSQERAVLVRLEGCSHPVVMKGLCAECGQDLTQLQSKNGKQQVPLSTATVSMVHSVPELMVSSEQAEQLGREDQQRLHRNRKL
VLMVDLDQTLIHTTEQHCQQMSNKGIFHFQLGRGEPMLHTRLRPHCKDFLEKIAKLYELHVFTFGSRLYAHTIAGFLDPEKKLFSHRILS
RDECIDPFSKTGNLRNLFPCGDSMVCIIDDREDVWKFAPNLITVKKYVYFQGTGDMNAPPGSRESQTRKKVNHSRGTEVSEPSPPVRDPE
GVTQAPGVEPSNGLEKPARELNGSEAATPRDSPRPGKPDERDIWPPAQAPTSSQELAGAPEPQGSCAQGGRVAPGQRPAQGATGTDLDFD
LSSDSESSSESEGTKSSSSASDGESEGKRGRQKPKAAPEGAGALAQGSSLEPGRPAAPSLPGEAEPGAHAPDKEPELGGQEEGERDGLCG
LGNGCADRKEAETESQNSELSGVTAGESLDQSMEEEEEEDTDEDDHLIYLEEILVRVHTDYYAKYDRYLNKEIEEAPDIRKIVPELKSKV
LADVAIIFSGLHPTNFPIEKTREHYHATALGAKILTRLVLSPDAPDRATHLIAARAGTEKVLQAQECGHLHVVNPDWLWSCLERWDKVEE
QLFPLRDDHTKAQRENSPAAFPDREGVPPTALFHPMPVLPKAQPGPEVRIYDSNTGKLIRTGARGPPAPSSSLPIRQEPSSFRWTTSLEK

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>57862_57862_2_NCOR2-CTDP1_NCOR2_chr12_124882664_ENST00000356219_CTDP1_chr18_77455224_ENST00000299543_length(amino acids)=868AA_BP=11
MDRRRNGNSQERAVLVRLEGCSHPVVMKGLCAECGQDLTQLQSKNGKQQVPLSTATVSMVHSVPELMVSSEQAEQLGREDQQRLHRNRKL
VLMVDLDQTLIHTTEQHCQQMSNKGIFHFQLGRGEPMLHTRLRPHCKDFLEKIAKLYELHVFTFGSRLYAHTIAGFLDPEKKLFSHRILS
RDECIDPFSKTGNLRNLFPCGDSMVCIIDDREDVWKFAPNLITVKKYVYFQGTGDMNAPPGSRESQTRKKVNHSRGTEVSEPSPPVRDPE
GVTQAPGVEPSNGLEKPARELNGSEAATPRDSPRPGKPDERDIWPPAQAPTSSQELAGAPEPQGSCAQGGRVAPGQRPAQGATGTDLDFD
LSSDSESSSESEGTKSSSSASDGESEGKRGRQKPKAAPEGAGALAQGSSLEPGRPAAPSLPGEAEPGAHAPDKEPELGGQEEGERDGLCG
LGNGCADRKEAETESQNSELSGVTAGESLDQSMEEEEEEDTDEDDHLIYLEEILVRVHTDYYAKYDRYLNKEIEEAPDIRKIVPELKSKV
LADVAIIFSGLHPTNFPIEKTREHYHATALGAKILTRLVLSPDAPDRATHLIAARAGTEKVLQAQECGHLHVVNPDWLWSCLERWDKVEE
QLFPLRDDHTKAQRENSPAAFPDREGVPPTALFHPMPVLPKAQPGPEVRIYDSNTGKLIRTGARGPPAPSSSLPIRQEPSSFRAVPPPQP
QMFGEELPDAQDGEQPGPSRRKRQPSMSETMPLYTLCKEDLESMDKEVDDILGEGSDDSDSEKRRPEEQEEEPQPRKPGTRRERTLGAPA

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>57862_57862_3_NCOR2-CTDP1_NCOR2_chr12_124882664_ENST00000397355_CTDP1_chr18_77455224_ENST00000075430_length(amino acids)=774AA_BP=11
MDRRRNGNSQERAVLVRLEGCSHPVVMKGLCAECGQDLTQLQSKNGKQQVPLSTATVSMVHSVPELMVSSEQAEQLGREDQQRLHRNRKL
VLMVDLDQTLIHTTEQHCQQMSNKGIFHFQLGRGEPMLHTRLRPHCKDFLEKIAKLYELHVFTFGSRLYAHTIAGFLDPEKKLFSHRILS
RDECIDPFSKTGNLRNLFPCGDSMVCIIDDREDVWKFAPNLITVKKYVYFQGTGDMNAPPGSRESQTRKKVNHSRGTEVSEPSPPVRDPE
GVTQAPGVEPSNGLEKPARELNGSEAATPRDSPRPGKPDERDIWPPAQAPTSSQELAGAPEPQGSCAQGGRVAPGQRPAQGATGTDLDFD
LSSDSESSSESEGTKSSSSASDGESEGKRGRQKPKAAPEGAGALAQGSSLEPGRPAAPSLPGEAEPGAHAPDKEPELGGQEEGERDGLCG
LGNGCADRKEAETESQNSELSGVTAGESLDQSMEEEEEEDTDEDDHLIYLEEILVRVHTDYYAKYDRYLNKEIEEAPDIRKIVPELKSKV
LADVAIIFSGLHPTNFPIEKTREHYHATALGAKILTRLVLSPDAPDRATHLIAARAGTEKVLQAQECGHLHVVNPDWLWSCLERWDKVEE
QLFPLRDDHTKAQRENSPAAFPDREGVPPTALFHPMPVLPKAQPGPEVRIYDSNTGKLIRTGARGPPAPSSSLPIRQEPSSFRWTTSLEK

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>57862_57862_4_NCOR2-CTDP1_NCOR2_chr12_124882664_ENST00000397355_CTDP1_chr18_77455224_ENST00000299543_length(amino acids)=868AA_BP=11
MDRRRNGNSQERAVLVRLEGCSHPVVMKGLCAECGQDLTQLQSKNGKQQVPLSTATVSMVHSVPELMVSSEQAEQLGREDQQRLHRNRKL
VLMVDLDQTLIHTTEQHCQQMSNKGIFHFQLGRGEPMLHTRLRPHCKDFLEKIAKLYELHVFTFGSRLYAHTIAGFLDPEKKLFSHRILS
RDECIDPFSKTGNLRNLFPCGDSMVCIIDDREDVWKFAPNLITVKKYVYFQGTGDMNAPPGSRESQTRKKVNHSRGTEVSEPSPPVRDPE
GVTQAPGVEPSNGLEKPARELNGSEAATPRDSPRPGKPDERDIWPPAQAPTSSQELAGAPEPQGSCAQGGRVAPGQRPAQGATGTDLDFD
LSSDSESSSESEGTKSSSSASDGESEGKRGRQKPKAAPEGAGALAQGSSLEPGRPAAPSLPGEAEPGAHAPDKEPELGGQEEGERDGLCG
LGNGCADRKEAETESQNSELSGVTAGESLDQSMEEEEEEDTDEDDHLIYLEEILVRVHTDYYAKYDRYLNKEIEEAPDIRKIVPELKSKV
LADVAIIFSGLHPTNFPIEKTREHYHATALGAKILTRLVLSPDAPDRATHLIAARAGTEKVLQAQECGHLHVVNPDWLWSCLERWDKVEE
QLFPLRDDHTKAQRENSPAAFPDREGVPPTALFHPMPVLPKAQPGPEVRIYDSNTGKLIRTGARGPPAPSSSLPIRQEPSSFRAVPPPQP
QMFGEELPDAQDGEQPGPSRRKRQPSMSETMPLYTLCKEDLESMDKEVDDILGEGSDDSDSEKRRPEEQEEEPQPRKPGTRRERTLGAPA

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>57862_57862_5_NCOR2-CTDP1_NCOR2_chr12_124882664_ENST00000404121_CTDP1_chr18_77455224_ENST00000075430_length(amino acids)=774AA_BP=11
MDRRRNGNSQERAVLVRLEGCSHPVVMKGLCAECGQDLTQLQSKNGKQQVPLSTATVSMVHSVPELMVSSEQAEQLGREDQQRLHRNRKL
VLMVDLDQTLIHTTEQHCQQMSNKGIFHFQLGRGEPMLHTRLRPHCKDFLEKIAKLYELHVFTFGSRLYAHTIAGFLDPEKKLFSHRILS
RDECIDPFSKTGNLRNLFPCGDSMVCIIDDREDVWKFAPNLITVKKYVYFQGTGDMNAPPGSRESQTRKKVNHSRGTEVSEPSPPVRDPE
GVTQAPGVEPSNGLEKPARELNGSEAATPRDSPRPGKPDERDIWPPAQAPTSSQELAGAPEPQGSCAQGGRVAPGQRPAQGATGTDLDFD
LSSDSESSSESEGTKSSSSASDGESEGKRGRQKPKAAPEGAGALAQGSSLEPGRPAAPSLPGEAEPGAHAPDKEPELGGQEEGERDGLCG
LGNGCADRKEAETESQNSELSGVTAGESLDQSMEEEEEEDTDEDDHLIYLEEILVRVHTDYYAKYDRYLNKEIEEAPDIRKIVPELKSKV
LADVAIIFSGLHPTNFPIEKTREHYHATALGAKILTRLVLSPDAPDRATHLIAARAGTEKVLQAQECGHLHVVNPDWLWSCLERWDKVEE
QLFPLRDDHTKAQRENSPAAFPDREGVPPTALFHPMPVLPKAQPGPEVRIYDSNTGKLIRTGARGPPAPSSSLPIRQEPSSFRWTTSLEK

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>57862_57862_6_NCOR2-CTDP1_NCOR2_chr12_124882664_ENST00000404121_CTDP1_chr18_77455224_ENST00000299543_length(amino acids)=868AA_BP=11
MDRRRNGNSQERAVLVRLEGCSHPVVMKGLCAECGQDLTQLQSKNGKQQVPLSTATVSMVHSVPELMVSSEQAEQLGREDQQRLHRNRKL
VLMVDLDQTLIHTTEQHCQQMSNKGIFHFQLGRGEPMLHTRLRPHCKDFLEKIAKLYELHVFTFGSRLYAHTIAGFLDPEKKLFSHRILS
RDECIDPFSKTGNLRNLFPCGDSMVCIIDDREDVWKFAPNLITVKKYVYFQGTGDMNAPPGSRESQTRKKVNHSRGTEVSEPSPPVRDPE
GVTQAPGVEPSNGLEKPARELNGSEAATPRDSPRPGKPDERDIWPPAQAPTSSQELAGAPEPQGSCAQGGRVAPGQRPAQGATGTDLDFD
LSSDSESSSESEGTKSSSSASDGESEGKRGRQKPKAAPEGAGALAQGSSLEPGRPAAPSLPGEAEPGAHAPDKEPELGGQEEGERDGLCG
LGNGCADRKEAETESQNSELSGVTAGESLDQSMEEEEEEDTDEDDHLIYLEEILVRVHTDYYAKYDRYLNKEIEEAPDIRKIVPELKSKV
LADVAIIFSGLHPTNFPIEKTREHYHATALGAKILTRLVLSPDAPDRATHLIAARAGTEKVLQAQECGHLHVVNPDWLWSCLERWDKVEE
QLFPLRDDHTKAQRENSPAAFPDREGVPPTALFHPMPVLPKAQPGPEVRIYDSNTGKLIRTGARGPPAPSSSLPIRQEPSSFRAVPPPQP
QMFGEELPDAQDGEQPGPSRRKRQPSMSETMPLYTLCKEDLESMDKEVDDILGEGSDDSDSEKRRPEEQEEEPQPRKPGTRRERTLGAPA

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>57862_57862_7_NCOR2-CTDP1_NCOR2_chr12_124882664_ENST00000404621_CTDP1_chr18_77455224_ENST00000075430_length(amino acids)=774AA_BP=11
MDRRRNGNSQERAVLVRLEGCSHPVVMKGLCAECGQDLTQLQSKNGKQQVPLSTATVSMVHSVPELMVSSEQAEQLGREDQQRLHRNRKL
VLMVDLDQTLIHTTEQHCQQMSNKGIFHFQLGRGEPMLHTRLRPHCKDFLEKIAKLYELHVFTFGSRLYAHTIAGFLDPEKKLFSHRILS
RDECIDPFSKTGNLRNLFPCGDSMVCIIDDREDVWKFAPNLITVKKYVYFQGTGDMNAPPGSRESQTRKKVNHSRGTEVSEPSPPVRDPE
GVTQAPGVEPSNGLEKPARELNGSEAATPRDSPRPGKPDERDIWPPAQAPTSSQELAGAPEPQGSCAQGGRVAPGQRPAQGATGTDLDFD
LSSDSESSSESEGTKSSSSASDGESEGKRGRQKPKAAPEGAGALAQGSSLEPGRPAAPSLPGEAEPGAHAPDKEPELGGQEEGERDGLCG
LGNGCADRKEAETESQNSELSGVTAGESLDQSMEEEEEEDTDEDDHLIYLEEILVRVHTDYYAKYDRYLNKEIEEAPDIRKIVPELKSKV
LADVAIIFSGLHPTNFPIEKTREHYHATALGAKILTRLVLSPDAPDRATHLIAARAGTEKVLQAQECGHLHVVNPDWLWSCLERWDKVEE
QLFPLRDDHTKAQRENSPAAFPDREGVPPTALFHPMPVLPKAQPGPEVRIYDSNTGKLIRTGARGPPAPSSSLPIRQEPSSFRWTTSLEK

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>57862_57862_8_NCOR2-CTDP1_NCOR2_chr12_124882664_ENST00000404621_CTDP1_chr18_77455224_ENST00000299543_length(amino acids)=868AA_BP=11
MDRRRNGNSQERAVLVRLEGCSHPVVMKGLCAECGQDLTQLQSKNGKQQVPLSTATVSMVHSVPELMVSSEQAEQLGREDQQRLHRNRKL
VLMVDLDQTLIHTTEQHCQQMSNKGIFHFQLGRGEPMLHTRLRPHCKDFLEKIAKLYELHVFTFGSRLYAHTIAGFLDPEKKLFSHRILS
RDECIDPFSKTGNLRNLFPCGDSMVCIIDDREDVWKFAPNLITVKKYVYFQGTGDMNAPPGSRESQTRKKVNHSRGTEVSEPSPPVRDPE
GVTQAPGVEPSNGLEKPARELNGSEAATPRDSPRPGKPDERDIWPPAQAPTSSQELAGAPEPQGSCAQGGRVAPGQRPAQGATGTDLDFD
LSSDSESSSESEGTKSSSSASDGESEGKRGRQKPKAAPEGAGALAQGSSLEPGRPAAPSLPGEAEPGAHAPDKEPELGGQEEGERDGLCG
LGNGCADRKEAETESQNSELSGVTAGESLDQSMEEEEEEDTDEDDHLIYLEEILVRVHTDYYAKYDRYLNKEIEEAPDIRKIVPELKSKV
LADVAIIFSGLHPTNFPIEKTREHYHATALGAKILTRLVLSPDAPDRATHLIAARAGTEKVLQAQECGHLHVVNPDWLWSCLERWDKVEE
QLFPLRDDHTKAQRENSPAAFPDREGVPPTALFHPMPVLPKAQPGPEVRIYDSNTGKLIRTGARGPPAPSSSLPIRQEPSSFRAVPPPQP
QMFGEELPDAQDGEQPGPSRRKRQPSMSETMPLYTLCKEDLESMDKEVDDILGEGSDDSDSEKRRPEEQEEEPQPRKPGTRRERTLGAPA

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>57862_57862_9_NCOR2-CTDP1_NCOR2_chr12_124882664_ENST00000429285_CTDP1_chr18_77455224_ENST00000075430_length(amino acids)=774AA_BP=11
MDRRRNGNSQERAVLVRLEGCSHPVVMKGLCAECGQDLTQLQSKNGKQQVPLSTATVSMVHSVPELMVSSEQAEQLGREDQQRLHRNRKL
VLMVDLDQTLIHTTEQHCQQMSNKGIFHFQLGRGEPMLHTRLRPHCKDFLEKIAKLYELHVFTFGSRLYAHTIAGFLDPEKKLFSHRILS
RDECIDPFSKTGNLRNLFPCGDSMVCIIDDREDVWKFAPNLITVKKYVYFQGTGDMNAPPGSRESQTRKKVNHSRGTEVSEPSPPVRDPE
GVTQAPGVEPSNGLEKPARELNGSEAATPRDSPRPGKPDERDIWPPAQAPTSSQELAGAPEPQGSCAQGGRVAPGQRPAQGATGTDLDFD
LSSDSESSSESEGTKSSSSASDGESEGKRGRQKPKAAPEGAGALAQGSSLEPGRPAAPSLPGEAEPGAHAPDKEPELGGQEEGERDGLCG
LGNGCADRKEAETESQNSELSGVTAGESLDQSMEEEEEEDTDEDDHLIYLEEILVRVHTDYYAKYDRYLNKEIEEAPDIRKIVPELKSKV
LADVAIIFSGLHPTNFPIEKTREHYHATALGAKILTRLVLSPDAPDRATHLIAARAGTEKVLQAQECGHLHVVNPDWLWSCLERWDKVEE
QLFPLRDDHTKAQRENSPAAFPDREGVPPTALFHPMPVLPKAQPGPEVRIYDSNTGKLIRTGARGPPAPSSSLPIRQEPSSFRWTTSLEK

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>57862_57862_10_NCOR2-CTDP1_NCOR2_chr12_124882664_ENST00000429285_CTDP1_chr18_77455224_ENST00000299543_length(amino acids)=868AA_BP=11
MDRRRNGNSQERAVLVRLEGCSHPVVMKGLCAECGQDLTQLQSKNGKQQVPLSTATVSMVHSVPELMVSSEQAEQLGREDQQRLHRNRKL
VLMVDLDQTLIHTTEQHCQQMSNKGIFHFQLGRGEPMLHTRLRPHCKDFLEKIAKLYELHVFTFGSRLYAHTIAGFLDPEKKLFSHRILS
RDECIDPFSKTGNLRNLFPCGDSMVCIIDDREDVWKFAPNLITVKKYVYFQGTGDMNAPPGSRESQTRKKVNHSRGTEVSEPSPPVRDPE
GVTQAPGVEPSNGLEKPARELNGSEAATPRDSPRPGKPDERDIWPPAQAPTSSQELAGAPEPQGSCAQGGRVAPGQRPAQGATGTDLDFD
LSSDSESSSESEGTKSSSSASDGESEGKRGRQKPKAAPEGAGALAQGSSLEPGRPAAPSLPGEAEPGAHAPDKEPELGGQEEGERDGLCG
LGNGCADRKEAETESQNSELSGVTAGESLDQSMEEEEEEDTDEDDHLIYLEEILVRVHTDYYAKYDRYLNKEIEEAPDIRKIVPELKSKV
LADVAIIFSGLHPTNFPIEKTREHYHATALGAKILTRLVLSPDAPDRATHLIAARAGTEKVLQAQECGHLHVVNPDWLWSCLERWDKVEE
QLFPLRDDHTKAQRENSPAAFPDREGVPPTALFHPMPVLPKAQPGPEVRIYDSNTGKLIRTGARGPPAPSSSLPIRQEPSSFRAVPPPQP
QMFGEELPDAQDGEQPGPSRRKRQPSMSETMPLYTLCKEDLESMDKEVDDILGEGSDDSDSEKRRPEEQEEEPQPRKPGTRRERTLGAPA

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Fusion Protein Functional Features

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr12:124882664/chr18:77455224)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
NCOR2 Q9Y618	CTDP1 Q9Y5B0
FUNCTION: Transcriptional corepressor (PubMed:20812024). Mediates the transcriptional repression activity of some nuclear receptors by promoting chromatin condensation, thus preventing access of the basal transcription. Isoform 1 and isoform 4 have different affinities for different nuclear receptors. Involved in the regulation BCL6-dependent of the germinal center (GC) reactions, mainly through the control of the GC B-cells proliferation and survival. Recruited by ZBTB7A to the androgen response elements/ARE on target genes, negatively regulates androgen receptor signaling and androgen-induced cell proliferation (PubMed:20812024). {ECO:0000269\|PubMed:18212045, ECO:0000269\|PubMed:20812024, ECO:0000269\|PubMed:23911289}.	FUNCTION: Processively dephosphorylates 'Ser-2' and 'Ser-5' of the heptad repeats YSPTSPS in the C-terminal domain of the largest RNA polymerase II subunit. This promotes the activity of RNA polymerase II. Plays a role in the exit from mitosis by dephosphorylating crucial mitotic substrates (USP44, CDC20 and WEE1) that are required for M-phase-promoting factor (MPF)/CDK1 inactivation. {ECO:0000269\|PubMed:22692537}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
* Minus value of BPloci means that the break pointn is located before the CDS.

- Retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

NCOR2

chr12:124882664

chr18:77455224

ENST00000356219

174_215

625.3333333333334

2522.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

NCOR2

chr12:124882664

chr18:77455224

ENST00000356219

522_561

625.3333333333334

2522.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

NCOR2

chr12:124882664

chr18:77455224

ENST00000356219

494_510

625.3333333333334

2522.0

Compositional bias

Note=Poly-Gln

Hgene

NCOR2

chr12:124882664

chr18:77455224

ENST00000356219

427_478

625.3333333333334

2522.0

Domain

SANT 1

Tgene

CTDP1

chr12:124882664

chr18:77455224

ENST00000075430

455_478

104.66666666666667

868.0

Compositional bias

Note=Ser-rich

Tgene

CTDP1

chr12:124882664

chr18:77455224

ENST00000075430

577_582

104.66666666666667

868.0

Compositional bias

Note=Poly-Glu

Tgene

CTDP1

chr12:124882664

chr18:77455224

ENST00000299543

455_478

104.66666666666667

962.0

Compositional bias

Note=Ser-rich

Tgene

CTDP1

chr12:124882664

chr18:77455224

ENST00000299543

577_582

104.66666666666667

962.0

Compositional bias

Note=Poly-Glu

Tgene

CTDP1

chr12:124882664

chr18:77455224

ENST00000075430

178_344

104.66666666666667

868.0

Domain

FCP1 homology

Tgene

CTDP1

chr12:124882664

chr18:77455224

ENST00000075430

629_728

104.66666666666667

868.0

Domain

BRCT

Tgene

CTDP1

chr12:124882664

chr18:77455224

ENST00000299543

178_344

104.66666666666667

962.0

Domain

FCP1 homology

Tgene

CTDP1

chr12:124882664

chr18:77455224

ENST00000299543

629_728

104.66666666666667

962.0

Domain

BRCT

- Not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

NCOR2

chr12:124882664

chr18:77455224

ENST00000356219

1384_1389

625.3333333333334

2522.0

Compositional bias

Note=Poly-Pro

Hgene

NCOR2

chr12:124882664

chr18:77455224

ENST00000356219

1839_1843

625.3333333333334

2522.0

Compositional bias

Note=Poly-Gly

Hgene

NCOR2

chr12:124882664

chr18:77455224

ENST00000356219

2476_2479

625.3333333333334

2522.0

Compositional bias

Note=Poly-Pro

Hgene

NCOR2

chr12:124882664

chr18:77455224

ENST00000356219

682_685

625.3333333333334

2522.0

Compositional bias

Note=Poly-Lys

Hgene

NCOR2

chr12:124882664

chr18:77455224

ENST00000356219

778_820

625.3333333333334

2522.0

Compositional bias

Note=Pro-rich

Hgene

NCOR2

chr12:124882664

chr18:77455224

ENST00000356219

995_1003

625.3333333333334

2522.0

Compositional bias

Note=Poly-Pro

Hgene

NCOR2

chr12:124882664

chr18:77455224

ENST00000356219

610_661

625.3333333333334

2522.0

Domain

SANT 2

Hgene

NCOR2

chr12:124882664

chr18:77455224

ENST00000356219

2136_2140

625.3333333333334

2522.0

Motif

Note=CORNR box of ID1

Hgene

NCOR2

chr12:124882664

chr18:77455224

ENST00000356219

2339_2343

625.3333333333334

2522.0

Motif

Note=CORNR box of ID2

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Fusion Protein-Protein Interaction

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)

Gene

PPI interactors

Protein-protein interactors based on sequence similarity (STRING)

Gene	STRING network
NCOR2
CTDP1

- Retained interactions in fusion protein (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost interactions due to fusion (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs to NCOR2-CTDP1

Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Drug

Source

PMID

Top

Related Diseases to NCOR2-CTDP1

Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Disease

Source

PMID

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source