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	Fusion Gene Summary
	Fusion Gene Sample Information
	Fusion ORF Analysis
	Fusion Amino Acid Sequences
	Fusion Protein Functional Features
	Fusion Protein-Protein Interaction
	Related drugs with this fusion protein
	Related disease with this fusion protein

Fusion Protein:NFATC3-CDH1

Fusion Protein Summary

Fusion gene summary

Fusion partner gene information	Fusion gene name: NFATC3-CDH1
	FusionPDB ID: 58803
	FusionGDB2.0 ID: 58803
		Hgene	Tgene
	Gene symbol	NFATC3	CDH1
	Gene ID	4775	51343
	Gene name	nuclear factor of activated T cells 3	fizzy and cell division cycle 20 related 1
	Synonyms	NF-AT4c\|NFAT4\|NFATX	CDC20C\|CDH1\|FZR\|FZR2\|HCDH\|HCDH1
	Cytomap	16q22.1	19p13.3
	Type of gene	protein-coding	protein-coding
	Description	nuclear factor of activated T-cells, cytoplasmic 3NF-ATc3T cell transcription factor NFAT4nuclear factor of activated T-cells c3 isoform IE-Xanuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3	fizzy-related protein homologCDC20 homolog 1CDC20-like 1bCDC20-like protein 1cdh1/Hct1 homologfizzy/cell division cycle 20 related 1
	Modification date	20200313	20200313
	UniProtAcc	Q12968	Q9H159
Ensembl transtripts involved in fusion gene	ENST ids	ENST00000329524, ENST00000346183, ENST00000349223, ENST00000575270, ENST00000535127,	ENST00000562836, ENST00000261769, ENST00000422392,
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)	* DoF score	9 X 4 X 9=324	19 X 20 X 5=1900
	# samples	11	23
	** MAII score	log2(11/324*10)=-1.55849028935997 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(23/1900*10)=-3.04629365227394 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)	PubMed: NFATC3 [Title/Abstract] AND CDH1 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)	NFATC3(68119687)-CDH1(68835572), # samples:1
Anticipated loss of major functional domain due to fusion event.	NFATC3-CDH1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. NFATC3-CDH1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. NFATC3-CDH1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. NFATC3-CDH1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	NFATC3	GO:0045944	positive regulation of transcription by RNA polymerase II	18815128
Hgene	NFATC3	GO:1905064	negative regulation of vascular smooth muscle cell differentiation	23853098
Tgene	CDH1	GO:0031145	anaphase-promoting complex-dependent catabolic process	18662541\|21596315
Tgene	CDH1	GO:0072425	signal transduction involved in G2 DNA damage checkpoint	18662541
Tgene	CDH1	GO:1904668	positive regulation of ubiquitin protein ligase activity	11459826

Fusion gene breakpoints across NFATC3 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across CDH1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

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Fusion Gene Sample Information

Fusion gene information from FusionGDB2.0.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	SKCM	TCGA-FS-A1ZQ	NFATC3	chr16	68119687	+	CDH1	chr16	68835572	+

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Fusion ORF Analysis

Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000575270	NFATC3	chr16	68119687	+	ENST00000261769	CDH1	chr16	68835572	+	4976	441	338	2926	862
ENST00000575270	NFATC3	chr16	68119687	+	ENST00000422392	CDH1	chr16	68835572	+	2781	441	338	2743	801
ENST00000349223	NFATC3	chr16	68119687	+	ENST00000261769	CDH1	chr16	68835572	+	4862	327	224	2812	862
ENST00000349223	NFATC3	chr16	68119687	+	ENST00000422392	CDH1	chr16	68835572	+	2667	327	224	2629	801
ENST00000329524	NFATC3	chr16	68119687	+	ENST00000261769	CDH1	chr16	68835572	+	4662	127	24	2612	862
ENST00000329524	NFATC3	chr16	68119687	+	ENST00000422392	CDH1	chr16	68835572	+	2467	127	24	2429	801
ENST00000346183	NFATC3	chr16	68119687	+	ENST00000261769	CDH1	chr16	68835572	+	4662	127	24	2612	862
ENST00000346183	NFATC3	chr16	68119687	+	ENST00000422392	CDH1	chr16	68835572	+	2467	127	24	2429	801

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000575270	ENST00000261769	NFATC3	chr16	68119687	+	CDH1	chr16	68835572	+	0.000365214	0.99963474
ENST00000575270	ENST00000422392	NFATC3	chr16	68119687	+	CDH1	chr16	68835572	+	0.001403643	0.9985964
ENST00000349223	ENST00000261769	NFATC3	chr16	68119687	+	CDH1	chr16	68835572	+	0.000363716	0.9996363
ENST00000349223	ENST00000422392	NFATC3	chr16	68119687	+	CDH1	chr16	68835572	+	0.001536002	0.998464
ENST00000329524	ENST00000261769	NFATC3	chr16	68119687	+	CDH1	chr16	68835572	+	0.000288133	0.9997118
ENST00000329524	ENST00000422392	NFATC3	chr16	68119687	+	CDH1	chr16	68835572	+	0.001202144	0.9987979
ENST00000346183	ENST00000261769	NFATC3	chr16	68119687	+	CDH1	chr16	68835572	+	0.000288133	0.9997118
ENST00000346183	ENST00000422392	NFATC3	chr16	68119687	+	CDH1	chr16	68835572	+	0.001202144	0.9987979

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Fusion Amino Acid Sequences

For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>58803_58803_1_NFATC3-CDH1_NFATC3_chr16_68119687_ENST00000329524_CDH1_chr16_68835572_ENST00000261769_length(amino acids)=862AA_BP=32
MTTANCGAHDELDFKLVFGEDGAPAPPPPGSRPAVNFEDCTGRQRTAYFSLDTRFKVGTDGVITVKRPLRFHNPQIHFLVYAWDSTYRKF
STKVTLNTVGHHHRPPPHQASVSGIQAELLTFPNSSPGLRRQKRDWVIPPISCPENEKGPFPKNLVQIKSNKDKEGKVFYSITGQGADTP
PVGVFIIERETGWLKVTEPLDRERIATYTLFSHAVSSNGNAVEDPMEILITVTDQNDNKPEFTQEVFKGSVMEGALPGTSVMEVTATDAD
DDVNTYNAAIAYTILSQDPELPDKNMFTINRNTGVISVVTTGLDRESFPTYTLVVQAADLQGEGLSTTATAVITVTDTNDNPPIFNPTTY
KGQVPENEANVVITTLKVTDADAPNTPAWEAVYTILNDDGGQFVVTTNPVNNDGILKTAKGLDFEAKQQYILHVAVTNVVPFEVSLTTST
ATVTVDVLDVNEAPIFVPPEKRVEVSEDFGVGQEITSYTAQEPDTFMEQKITYRIWRDTANWLEINPDTGAISTRAELDREDFEHVKNST
YTALIIATDNGSPVATGTGTLLLILSDVNDNAPIPEPRTIFFCERNPKPQVINIIDADLPPNTSPFTAELTHGASANWTIQYNDPTQESI
ILKPKMALEVGDYKINLKLMDNQNKDQVTTLEVSVCDCEGAAGVCRKAQPVEAGLQIPAILGILGGILALLILILLLLLFLRRRAVVKEP
LLPPEDDTRDNVYYYDEEGGGEEDQDFDLSQLHRGLDARPEVTRNDVAPTLMSVPRYLPRPANPDEIGNFIDENLKAADTDPTAPPYDSL

--------------------------------------------------------------

>58803_58803_2_NFATC3-CDH1_NFATC3_chr16_68119687_ENST00000329524_CDH1_chr16_68835572_ENST00000422392_length(amino acids)=801AA_BP=32
MTTANCGAHDELDFKLVFGEDGAPAPPPPGSRPAVNFEDCTGRQRTAYFSLDTRFKVGTDGVITVKRPLRFHNPQIHFLVYAWDSTYRKF
STKVTLNTVGHHHRPPPHQASVSGIQAELLTFPNSSPGLRRQKRDWVIPPISCPENEKGPFPKNLVQIKSNKDKEGKVFYSITGQGADTP
PVGVFIIERETGWLKVTEPLDRERIATYTLFSHAVSSNGNAVEDPMEILITVTDQNDNKPEFTQEVFKGSVMEGALPGTSVMEVTATDAD
DDVNTYNAAIAYTILSQDPELPDKNMFTINRNTGVISVVTTGLDRESFPTYTLVVQAADLQGEGLSTTATAVITVTDTNDNPPIFNPTTG
LDFEAKQQYILHVAVTNVVPFEVSLTTSTATVTVDVLDVNEAPIFVPPEKRVEVSEDFGVGQEITSYTAQEPDTFMEQKITYRIWRDTAN
WLEINPDTGAISTRAELDREDFEHVKNSTYTALIIATDNGSPVATGTGTLLLILSDVNDNAPIPEPRTIFFCERNPKPQVINIIDADLPP
NTSPFTAELTHGASANWTIQYNDPTQESIILKPKMALEVGDYKINLKLMDNQNKDQVTTLEVSVCDCEGAAGVCRKAQPVEAGLQIPAIL
GILGGILALLILILLLLLFLRRRAVVKEPLLPPEDDTRDNVYYYDEEGGGEEDQDFDLSQLHRGLDARPEVTRNDVAPTLMSVPRYLPRP

--------------------------------------------------------------

>58803_58803_3_NFATC3-CDH1_NFATC3_chr16_68119687_ENST00000346183_CDH1_chr16_68835572_ENST00000261769_length(amino acids)=862AA_BP=32
MTTANCGAHDELDFKLVFGEDGAPAPPPPGSRPAVNFEDCTGRQRTAYFSLDTRFKVGTDGVITVKRPLRFHNPQIHFLVYAWDSTYRKF
STKVTLNTVGHHHRPPPHQASVSGIQAELLTFPNSSPGLRRQKRDWVIPPISCPENEKGPFPKNLVQIKSNKDKEGKVFYSITGQGADTP
PVGVFIIERETGWLKVTEPLDRERIATYTLFSHAVSSNGNAVEDPMEILITVTDQNDNKPEFTQEVFKGSVMEGALPGTSVMEVTATDAD
DDVNTYNAAIAYTILSQDPELPDKNMFTINRNTGVISVVTTGLDRESFPTYTLVVQAADLQGEGLSTTATAVITVTDTNDNPPIFNPTTY
KGQVPENEANVVITTLKVTDADAPNTPAWEAVYTILNDDGGQFVVTTNPVNNDGILKTAKGLDFEAKQQYILHVAVTNVVPFEVSLTTST
ATVTVDVLDVNEAPIFVPPEKRVEVSEDFGVGQEITSYTAQEPDTFMEQKITYRIWRDTANWLEINPDTGAISTRAELDREDFEHVKNST
YTALIIATDNGSPVATGTGTLLLILSDVNDNAPIPEPRTIFFCERNPKPQVINIIDADLPPNTSPFTAELTHGASANWTIQYNDPTQESI
ILKPKMALEVGDYKINLKLMDNQNKDQVTTLEVSVCDCEGAAGVCRKAQPVEAGLQIPAILGILGGILALLILILLLLLFLRRRAVVKEP
LLPPEDDTRDNVYYYDEEGGGEEDQDFDLSQLHRGLDARPEVTRNDVAPTLMSVPRYLPRPANPDEIGNFIDENLKAADTDPTAPPYDSL

--------------------------------------------------------------

>58803_58803_4_NFATC3-CDH1_NFATC3_chr16_68119687_ENST00000346183_CDH1_chr16_68835572_ENST00000422392_length(amino acids)=801AA_BP=32
MTTANCGAHDELDFKLVFGEDGAPAPPPPGSRPAVNFEDCTGRQRTAYFSLDTRFKVGTDGVITVKRPLRFHNPQIHFLVYAWDSTYRKF
STKVTLNTVGHHHRPPPHQASVSGIQAELLTFPNSSPGLRRQKRDWVIPPISCPENEKGPFPKNLVQIKSNKDKEGKVFYSITGQGADTP
PVGVFIIERETGWLKVTEPLDRERIATYTLFSHAVSSNGNAVEDPMEILITVTDQNDNKPEFTQEVFKGSVMEGALPGTSVMEVTATDAD
DDVNTYNAAIAYTILSQDPELPDKNMFTINRNTGVISVVTTGLDRESFPTYTLVVQAADLQGEGLSTTATAVITVTDTNDNPPIFNPTTG
LDFEAKQQYILHVAVTNVVPFEVSLTTSTATVTVDVLDVNEAPIFVPPEKRVEVSEDFGVGQEITSYTAQEPDTFMEQKITYRIWRDTAN
WLEINPDTGAISTRAELDREDFEHVKNSTYTALIIATDNGSPVATGTGTLLLILSDVNDNAPIPEPRTIFFCERNPKPQVINIIDADLPP
NTSPFTAELTHGASANWTIQYNDPTQESIILKPKMALEVGDYKINLKLMDNQNKDQVTTLEVSVCDCEGAAGVCRKAQPVEAGLQIPAIL
GILGGILALLILILLLLLFLRRRAVVKEPLLPPEDDTRDNVYYYDEEGGGEEDQDFDLSQLHRGLDARPEVTRNDVAPTLMSVPRYLPRP

--------------------------------------------------------------

>58803_58803_5_NFATC3-CDH1_NFATC3_chr16_68119687_ENST00000349223_CDH1_chr16_68835572_ENST00000261769_length(amino acids)=862AA_BP=32
MTTANCGAHDELDFKLVFGEDGAPAPPPPGSRPAVNFEDCTGRQRTAYFSLDTRFKVGTDGVITVKRPLRFHNPQIHFLVYAWDSTYRKF
STKVTLNTVGHHHRPPPHQASVSGIQAELLTFPNSSPGLRRQKRDWVIPPISCPENEKGPFPKNLVQIKSNKDKEGKVFYSITGQGADTP
PVGVFIIERETGWLKVTEPLDRERIATYTLFSHAVSSNGNAVEDPMEILITVTDQNDNKPEFTQEVFKGSVMEGALPGTSVMEVTATDAD
DDVNTYNAAIAYTILSQDPELPDKNMFTINRNTGVISVVTTGLDRESFPTYTLVVQAADLQGEGLSTTATAVITVTDTNDNPPIFNPTTY
KGQVPENEANVVITTLKVTDADAPNTPAWEAVYTILNDDGGQFVVTTNPVNNDGILKTAKGLDFEAKQQYILHVAVTNVVPFEVSLTTST
ATVTVDVLDVNEAPIFVPPEKRVEVSEDFGVGQEITSYTAQEPDTFMEQKITYRIWRDTANWLEINPDTGAISTRAELDREDFEHVKNST
YTALIIATDNGSPVATGTGTLLLILSDVNDNAPIPEPRTIFFCERNPKPQVINIIDADLPPNTSPFTAELTHGASANWTIQYNDPTQESI
ILKPKMALEVGDYKINLKLMDNQNKDQVTTLEVSVCDCEGAAGVCRKAQPVEAGLQIPAILGILGGILALLILILLLLLFLRRRAVVKEP
LLPPEDDTRDNVYYYDEEGGGEEDQDFDLSQLHRGLDARPEVTRNDVAPTLMSVPRYLPRPANPDEIGNFIDENLKAADTDPTAPPYDSL

--------------------------------------------------------------

>58803_58803_6_NFATC3-CDH1_NFATC3_chr16_68119687_ENST00000349223_CDH1_chr16_68835572_ENST00000422392_length(amino acids)=801AA_BP=32
MTTANCGAHDELDFKLVFGEDGAPAPPPPGSRPAVNFEDCTGRQRTAYFSLDTRFKVGTDGVITVKRPLRFHNPQIHFLVYAWDSTYRKF
STKVTLNTVGHHHRPPPHQASVSGIQAELLTFPNSSPGLRRQKRDWVIPPISCPENEKGPFPKNLVQIKSNKDKEGKVFYSITGQGADTP
PVGVFIIERETGWLKVTEPLDRERIATYTLFSHAVSSNGNAVEDPMEILITVTDQNDNKPEFTQEVFKGSVMEGALPGTSVMEVTATDAD
DDVNTYNAAIAYTILSQDPELPDKNMFTINRNTGVISVVTTGLDRESFPTYTLVVQAADLQGEGLSTTATAVITVTDTNDNPPIFNPTTG
LDFEAKQQYILHVAVTNVVPFEVSLTTSTATVTVDVLDVNEAPIFVPPEKRVEVSEDFGVGQEITSYTAQEPDTFMEQKITYRIWRDTAN
WLEINPDTGAISTRAELDREDFEHVKNSTYTALIIATDNGSPVATGTGTLLLILSDVNDNAPIPEPRTIFFCERNPKPQVINIIDADLPP
NTSPFTAELTHGASANWTIQYNDPTQESIILKPKMALEVGDYKINLKLMDNQNKDQVTTLEVSVCDCEGAAGVCRKAQPVEAGLQIPAIL
GILGGILALLILILLLLLFLRRRAVVKEPLLPPEDDTRDNVYYYDEEGGGEEDQDFDLSQLHRGLDARPEVTRNDVAPTLMSVPRYLPRP

--------------------------------------------------------------

>58803_58803_7_NFATC3-CDH1_NFATC3_chr16_68119687_ENST00000575270_CDH1_chr16_68835572_ENST00000261769_length(amino acids)=862AA_BP=32
MTTANCGAHDELDFKLVFGEDGAPAPPPPGSRPAVNFEDCTGRQRTAYFSLDTRFKVGTDGVITVKRPLRFHNPQIHFLVYAWDSTYRKF
STKVTLNTVGHHHRPPPHQASVSGIQAELLTFPNSSPGLRRQKRDWVIPPISCPENEKGPFPKNLVQIKSNKDKEGKVFYSITGQGADTP
PVGVFIIERETGWLKVTEPLDRERIATYTLFSHAVSSNGNAVEDPMEILITVTDQNDNKPEFTQEVFKGSVMEGALPGTSVMEVTATDAD
DDVNTYNAAIAYTILSQDPELPDKNMFTINRNTGVISVVTTGLDRESFPTYTLVVQAADLQGEGLSTTATAVITVTDTNDNPPIFNPTTY
KGQVPENEANVVITTLKVTDADAPNTPAWEAVYTILNDDGGQFVVTTNPVNNDGILKTAKGLDFEAKQQYILHVAVTNVVPFEVSLTTST
ATVTVDVLDVNEAPIFVPPEKRVEVSEDFGVGQEITSYTAQEPDTFMEQKITYRIWRDTANWLEINPDTGAISTRAELDREDFEHVKNST
YTALIIATDNGSPVATGTGTLLLILSDVNDNAPIPEPRTIFFCERNPKPQVINIIDADLPPNTSPFTAELTHGASANWTIQYNDPTQESI
ILKPKMALEVGDYKINLKLMDNQNKDQVTTLEVSVCDCEGAAGVCRKAQPVEAGLQIPAILGILGGILALLILILLLLLFLRRRAVVKEP
LLPPEDDTRDNVYYYDEEGGGEEDQDFDLSQLHRGLDARPEVTRNDVAPTLMSVPRYLPRPANPDEIGNFIDENLKAADTDPTAPPYDSL

--------------------------------------------------------------

>58803_58803_8_NFATC3-CDH1_NFATC3_chr16_68119687_ENST00000575270_CDH1_chr16_68835572_ENST00000422392_length(amino acids)=801AA_BP=32
MTTANCGAHDELDFKLVFGEDGAPAPPPPGSRPAVNFEDCTGRQRTAYFSLDTRFKVGTDGVITVKRPLRFHNPQIHFLVYAWDSTYRKF
STKVTLNTVGHHHRPPPHQASVSGIQAELLTFPNSSPGLRRQKRDWVIPPISCPENEKGPFPKNLVQIKSNKDKEGKVFYSITGQGADTP
PVGVFIIERETGWLKVTEPLDRERIATYTLFSHAVSSNGNAVEDPMEILITVTDQNDNKPEFTQEVFKGSVMEGALPGTSVMEVTATDAD
DDVNTYNAAIAYTILSQDPELPDKNMFTINRNTGVISVVTTGLDRESFPTYTLVVQAADLQGEGLSTTATAVITVTDTNDNPPIFNPTTG
LDFEAKQQYILHVAVTNVVPFEVSLTTSTATVTVDVLDVNEAPIFVPPEKRVEVSEDFGVGQEITSYTAQEPDTFMEQKITYRIWRDTAN
WLEINPDTGAISTRAELDREDFEHVKNSTYTALIIATDNGSPVATGTGTLLLILSDVNDNAPIPEPRTIFFCERNPKPQVINIIDADLPP
NTSPFTAELTHGASANWTIQYNDPTQESIILKPKMALEVGDYKINLKLMDNQNKDQVTTLEVSVCDCEGAAGVCRKAQPVEAGLQIPAIL
GILGGILALLILILLLLLFLRRRAVVKEPLLPPEDDTRDNVYYYDEEGGGEEDQDFDLSQLHRGLDARPEVTRNDVAPTLMSVPRYLPRP

--------------------------------------------------------------

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Fusion Protein Functional Features

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr16:68119687/chr16:68835572)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
NFATC3 Q12968	CDH1 Q9H159
FUNCTION: Acts as a regulator of transcriptional activation. Plays a role in the inducible expression of cytokine genes in T-cells, especially in the induction of the IL-2 (PubMed:18815128). Along with NFATC4, involved in embryonic heart development (By similarity). {ECO:0000250\|UniProtKB:P97305, ECO:0000269\|PubMed:18815128}.	FUNCTION: Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
* Minus value of BPloci means that the break pointn is located before the CDS.

- Retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

NFATC3

chr16:68119687

chr16:68835572

ENST00000329524

24_29

34.333333333333336

1996.6666666666667

Compositional bias

Note=Poly-Pro

Hgene

NFATC3

chr16:68119687

chr16:68835572

ENST00000346183

24_29

34.333333333333336

1076.0

Compositional bias

Note=Poly-Pro

Hgene

NFATC3

chr16:68119687

chr16:68835572

ENST00000349223

24_29

34.333333333333336

1066.0

Compositional bias

Note=Poly-Pro

Tgene

CDH1

chr16:68119687

chr16:68835572

ENST00000261769

838_851

54.333333333333336

883.0

Compositional bias

Note=Ser-rich

Tgene

CDH1

chr16:68119687

chr16:68835572

ENST00000261769

155_262

54.333333333333336

883.0

Domain

Cadherin 1

Tgene

CDH1

chr16:68119687

chr16:68835572

ENST00000261769

263_375

54.333333333333336

883.0

Domain

Cadherin 2

Tgene

CDH1

chr16:68119687

chr16:68835572

ENST00000261769

376_486

54.333333333333336

883.0

Domain

Cadherin 3

Tgene

CDH1

chr16:68119687

chr16:68835572

ENST00000261769

487_593

54.333333333333336

883.0

Domain

Cadherin 4

Tgene

CDH1

chr16:68119687

chr16:68835572

ENST00000261769

594_697

54.333333333333336

883.0

Domain

Cadherin 5

Tgene

CDH1

chr16:68119687

chr16:68835572

ENST00000261769

758_769

54.333333333333336

883.0

Region

Note=Required for binding CTNND1 and PSEN1

Tgene

CDH1

chr16:68119687

chr16:68835572

ENST00000261769

811_882

54.333333333333336

883.0

Region

Note=Required for binding alpha%2C beta and gamma catenins

Tgene

CDH1

chr16:68119687

chr16:68835572

ENST00000261769

155_709

54.333333333333336

883.0

Topological domain

Extracellular

Tgene

CDH1

chr16:68119687

chr16:68835572

ENST00000261769

731_882

54.333333333333336

883.0

Topological domain

Cytoplasmic

Tgene

CDH1

chr16:68119687

chr16:68835572

ENST00000261769

710_730

54.333333333333336

883.0

Transmembrane

Helical

- Not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

NFATC3

chr16:68119687

chr16:68835572

ENST00000329524

444_451

34.333333333333336

1996.6666666666667

DNA binding

Hgene

NFATC3

chr16:68119687

chr16:68835572

ENST00000346183

444_451

34.333333333333336

1076.0

DNA binding

Hgene

NFATC3

chr16:68119687

chr16:68835572

ENST00000349223

444_451

34.333333333333336

1066.0

DNA binding

Hgene

NFATC3

chr16:68119687

chr16:68835572

ENST00000329524

415_596

34.333333333333336

1996.6666666666667

Domain

RHD

Hgene

NFATC3

chr16:68119687

chr16:68835572

ENST00000346183

415_596

34.333333333333336

1076.0

Domain

RHD

Hgene

NFATC3

chr16:68119687

chr16:68835572

ENST00000349223

415_596

34.333333333333336

1066.0

Domain

RHD

Hgene

NFATC3

chr16:68119687

chr16:68835572

ENST00000329524

1032_1041

34.333333333333336

1996.6666666666667

Motif

Note=Nuclear export signal

Hgene

NFATC3

chr16:68119687

chr16:68835572

ENST00000329524

273_275

34.333333333333336

1996.6666666666667

Motif

Note=Nuclear localization signal

Hgene

NFATC3

chr16:68119687

chr16:68835572

ENST00000329524

686_688

34.333333333333336

1996.6666666666667

Motif

Note=Nuclear localization signal

Hgene

NFATC3

chr16:68119687

chr16:68835572

ENST00000346183

1032_1041

34.333333333333336

1076.0

Motif

Note=Nuclear export signal

Hgene

NFATC3

chr16:68119687

chr16:68835572

ENST00000346183

273_275

34.333333333333336

1076.0

Motif

Note=Nuclear localization signal

Hgene

NFATC3

chr16:68119687

chr16:68835572

ENST00000346183

686_688

34.333333333333336

1076.0

Motif

Note=Nuclear localization signal

Hgene

NFATC3

chr16:68119687

chr16:68835572

ENST00000349223

1032_1041

34.333333333333336

1066.0

Motif

Note=Nuclear export signal

Hgene

NFATC3

chr16:68119687

chr16:68835572

ENST00000349223

273_275

34.333333333333336

1066.0

Motif

Note=Nuclear localization signal

Hgene

NFATC3

chr16:68119687

chr16:68835572

ENST00000349223

686_688

34.333333333333336

1066.0

Motif

Note=Nuclear localization signal

Hgene

NFATC3

chr16:68119687

chr16:68835572

ENST00000329524

109_114

34.333333333333336

1996.6666666666667

Region

Note=Calcineurin-binding

Hgene

NFATC3

chr16:68119687

chr16:68835572

ENST00000329524

207_308

34.333333333333336

1996.6666666666667

Region

Note=3 X SP repeats

Hgene

NFATC3

chr16:68119687

chr16:68835572

ENST00000346183

109_114

34.333333333333336

1076.0

Region

Note=Calcineurin-binding

Hgene

NFATC3

chr16:68119687

chr16:68835572

ENST00000346183

207_308

34.333333333333336

1076.0

Region

Note=3 X SP repeats

Hgene

NFATC3

chr16:68119687

chr16:68835572

ENST00000349223

109_114

34.333333333333336

1066.0

Region

Note=Calcineurin-binding

Hgene

NFATC3

chr16:68119687

chr16:68835572

ENST00000349223

207_308

34.333333333333336

1066.0

Region

Note=3 X SP repeats

Hgene

NFATC3

chr16:68119687

chr16:68835572

ENST00000329524

207_223

34.333333333333336

1996.6666666666667

Repeat

Note=1

Hgene

NFATC3

chr16:68119687

chr16:68835572

ENST00000329524

236_252

34.333333333333336

1996.6666666666667

Repeat

Note=2

Hgene

NFATC3

chr16:68119687

chr16:68835572

ENST00000329524

292_308

34.333333333333336

1996.6666666666667

Repeat

Note=3

Hgene

NFATC3

chr16:68119687

chr16:68835572

ENST00000346183

207_223

34.333333333333336

1076.0

Repeat

Note=1

Hgene

NFATC3

chr16:68119687

chr16:68835572

ENST00000346183

236_252

34.333333333333336

1076.0

Repeat

Note=2

Hgene

NFATC3

chr16:68119687

chr16:68835572

ENST00000346183

292_308

34.333333333333336

1076.0

Repeat

Note=3

Hgene

NFATC3

chr16:68119687

chr16:68835572

ENST00000349223

207_223

34.333333333333336

1066.0

Repeat

Note=1

Hgene

NFATC3

chr16:68119687

chr16:68835572

ENST00000349223

236_252

34.333333333333336

1066.0

Repeat

Note=2

Hgene

NFATC3

chr16:68119687

chr16:68835572

ENST00000349223

292_308

34.333333333333336

1066.0

Repeat

Note=3

Top

Fusion Protein-Protein Interaction

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)

Gene

PPI interactors

Protein-protein interactors based on sequence similarity (STRING)

Gene	STRING network
NFATC3
CDH1

- Retained interactions in fusion protein (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost interactions due to fusion (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs to NFATC3-CDH1

Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Drug

Source

PMID

Top

Related Diseases to NFATC3-CDH1

Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Disease

Source

PMID

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source