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Center for Computational Systems Medicine level1
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:NFE2L2-VMP1

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: NFE2L2-VMP1
FusionPDB ID: 58849
FusionGDB2.0 ID: 58849
HgeneTgene
Gene symbol

NFE2L2

VMP1

Gene ID

4780

81671

Gene namenuclear factor, erythroid 2 like 2vacuole membrane protein 1
SynonymsHEBP1|IMDDHH|NRF2|Nrf-2EPG3|TANGO5|TMEM49
Cytomap

2q31.2

17q23.1

Type of geneprotein-codingprotein-coding
Descriptionnuclear factor erythroid 2-related factor 2nuclear factor erythroid-derived 2-like 2vacuole membrane protein 1ectopic P-granules autophagy protein 3 homologtransmembrane protein 49transport and golgi organization 5 homolog
Modification date2020032920200327
UniProtAcc

Q16236

.
Ensembl transtripts involved in fusion geneENST idsENST00000397062, ENST00000397063, 
ENST00000423513, ENST00000446151, 
ENST00000464747, 		ENST00000588617, 
ENST00000262291, ENST00000536180, 
ENST00000537567, ENST00000539763, 
ENST00000545362, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score18 X 18 X 9=291642 X 34 X 19=27132
# samples 29151
** MAII scorelog2(29/2916*10)=-3.329865914312
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(151/27132*10)=-4.16737494326024
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: NFE2L2 [Title/Abstract] AND VMP1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)NFE2L2(178129260)-VMP1(57851115), # samples:3
Anticipated loss of major functional domain due to fusion event.NFE2L2-VMP1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
NFE2L2-VMP1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneNFE2L2

GO:0010499

proteasomal ubiquitin-independent protein catabolic process

19424503

HgeneNFE2L2

GO:0016567

protein ubiquitination

15983046

HgeneNFE2L2

GO:0043161

proteasome-mediated ubiquitin-dependent protein catabolic process

15983046

HgeneNFE2L2

GO:0045944

positive regulation of transcription by RNA polymerase II

17015834

HgeneNFE2L2

GO:0071498

cellular response to fluid shear stress

25190803


check buttonFusion gene breakpoints across NFE2L2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across VMP1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4STADTCGA-VQ-A8PM-01ANFE2L2chr2

178128131

-VMP1chr17

57851115

+
ChimerDB4STADTCGA-VQ-A8PM-01ANFE2L2chr2

178129260

-VMP1chr17

57851115

+
ChimerDB4STADTCGA-VQ-A8PM-01ANFE2L2chr2

178129260

-VMP1chr17

57886157

+
ChimerDB4STADTCGA-VQ-A8PMNFE2L2chr2

178128130

-VMP1chr17

57851114

+
ChimerDB4STADTCGA-VQ-A8PMNFE2L2chr2

178129259

-VMP1chr17

57851114

+
ChimerDB4STADTCGA-VQ-A8PMNFE2L2chr2

178129259

-VMP1chr17

57886156

+


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000397062NFE2L2chr2178129260-ENST00000262291VMP1chr1757851115+24206005551238227
ENST00000397062NFE2L2chr2178129260-ENST00000537567VMP1chr1757851115+14996005551238227
ENST00000397062NFE2L2chr2178129260-ENST00000539763VMP1chr1757851115+14596005551238227
ENST00000397062NFE2L2chr2178129260-ENST00000536180VMP1chr1757851115+13316005551238227
ENST00000397062NFE2L2chr2178129260-ENST00000545362VMP1chr1757851115+14916005551238227
ENST00000397062NFE2L2chr2178129259-ENST00000262291VMP1chr1757851114+24206005551238227
ENST00000397062NFE2L2chr2178129259-ENST00000537567VMP1chr1757851114+14996005551238227
ENST00000397062NFE2L2chr2178129259-ENST00000539763VMP1chr1757851114+14596005551238227
ENST00000397062NFE2L2chr2178129259-ENST00000536180VMP1chr1757851114+13316005551238227
ENST00000397062NFE2L2chr2178129259-ENST00000545362VMP1chr1757851114+14916005551238227
ENST00000397062NFE2L2chr2178129259-ENST00000262291VMP1chr1757886156+2288600137700187
ENST00000397062NFE2L2chr2178129259-ENST00000537567VMP1chr1757886156+1367600137700187
ENST00000397062NFE2L2chr2178129259-ENST00000539763VMP1chr1757886156+1327600137700187
ENST00000397062NFE2L2chr2178129259-ENST00000536180VMP1chr1757886156+1199600137700187
ENST00000397062NFE2L2chr2178129259-ENST00000545362VMP1chr1757886156+1359600137700187
ENST00000397062NFE2L2chr2178129260-ENST00000262291VMP1chr1757886157+2288600137700187
ENST00000397062NFE2L2chr2178129260-ENST00000537567VMP1chr1757886157+1367600137700187
ENST00000397062NFE2L2chr2178129260-ENST00000539763VMP1chr1757886157+1327600137700187
ENST00000397062NFE2L2chr2178129260-ENST00000536180VMP1chr1757886157+1199600137700187
ENST00000397062NFE2L2chr2178129260-ENST00000545362VMP1chr1757886157+1359600137700187

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000397062ENST00000262291NFE2L2chr2178129260-VMP1chr1757851115+0.0006418440.9993581
ENST00000397062ENST00000537567NFE2L2chr2178129260-VMP1chr1757851115+0.0020298730.99797016
ENST00000397062ENST00000539763NFE2L2chr2178129260-VMP1chr1757851115+0.0023264440.9976736
ENST00000397062ENST00000536180NFE2L2chr2178129260-VMP1chr1757851115+0.0036022920.99639773
ENST00000397062ENST00000545362NFE2L2chr2178129260-VMP1chr1757851115+0.0021241220.9978759
ENST00000397062ENST00000262291NFE2L2chr2178129259-VMP1chr1757851114+0.0006418440.9993581
ENST00000397062ENST00000537567NFE2L2chr2178129259-VMP1chr1757851114+0.0020298730.99797016
ENST00000397062ENST00000539763NFE2L2chr2178129259-VMP1chr1757851114+0.0023264440.9976736
ENST00000397062ENST00000536180NFE2L2chr2178129259-VMP1chr1757851114+0.0036022920.99639773
ENST00000397062ENST00000545362NFE2L2chr2178129259-VMP1chr1757851114+0.0021241220.9978759
ENST00000397062ENST00000262291NFE2L2chr2178129259-VMP1chr1757886156+0.0052783310.99472165
ENST00000397062ENST00000537567NFE2L2chr2178129259-VMP1chr1757886156+0.0073989470.992601
ENST00000397062ENST00000539763NFE2L2chr2178129259-VMP1chr1757886156+0.0081397140.99186033
ENST00000397062ENST00000536180NFE2L2chr2178129259-VMP1chr1757886156+0.0130111680.9869889
ENST00000397062ENST00000545362NFE2L2chr2178129259-VMP1chr1757886156+0.0076982770.9923017
ENST00000397062ENST00000262291NFE2L2chr2178129260-VMP1chr1757886157+0.0052783310.99472165
ENST00000397062ENST00000537567NFE2L2chr2178129260-VMP1chr1757886157+0.0073989470.992601
ENST00000397062ENST00000539763NFE2L2chr2178129260-VMP1chr1757886157+0.0081397140.99186033
ENST00000397062ENST00000536180NFE2L2chr2178129260-VMP1chr1757886157+0.0130111680.9869889
ENST00000397062ENST00000545362NFE2L2chr2178129260-VMP1chr1757886157+0.0076982770.9923017

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>58849_58849_1_NFE2L2-VMP1_NFE2L2_chr2_178129259_ENST00000397062_VMP1_chr17_57851114_ENST00000262291_length(amino acids)=227AA_BP=15
MMDLELPPPGLPSQQGIGTAIGELPPYFMARAARLSGAEPDDEEYQEFEEMLEHAESAQDFASRAKLAVQKLVQKVGFFGILACASIPNP
LFDLAGITCGHFLVPFWTFFGATLIGKAIIKMHIQKIFVIITFSKHIVEQMVAFIGAVPGIGPSLQKPFQEYLEAQRQKLHHKSEMGTPQ

--------------------------------------------------------------

>58849_58849_2_NFE2L2-VMP1_NFE2L2_chr2_178129259_ENST00000397062_VMP1_chr17_57851114_ENST00000536180_length(amino acids)=227AA_BP=15
MMDLELPPPGLPSQQGIGTAIGELPPYFMARAARLSGAEPDDEEYQEFEEMLEHAESAQDFASRAKLAVQKLVQKVGFFGILACASIPNP
LFDLAGITCGHFLVPFWTFFGATLIGKAIIKMHIQKIFVIITFSKHIVEQMVAFIGAVPGIGPSLQKPFQEYLEAQRQKLHHKSEMGTPQ

--------------------------------------------------------------

>58849_58849_3_NFE2L2-VMP1_NFE2L2_chr2_178129259_ENST00000397062_VMP1_chr17_57851114_ENST00000537567_length(amino acids)=227AA_BP=15
MMDLELPPPGLPSQQGIGTAIGELPPYFMARAARLSGAEPDDEEYQEFEEMLEHAESAQDFASRAKLAVQKLVQKVGFFGILACASIPNP
LFDLAGITCGHFLVPFWTFFGATLIGKAIIKMHIQKIFVIITFSKHIVEQMVAFIGAVPGIGPSLQKPFQEYLEAQRQKLHHKSEMGTPQ

--------------------------------------------------------------

>58849_58849_4_NFE2L2-VMP1_NFE2L2_chr2_178129259_ENST00000397062_VMP1_chr17_57851114_ENST00000539763_length(amino acids)=227AA_BP=15
MMDLELPPPGLPSQQGIGTAIGELPPYFMARAARLSGAEPDDEEYQEFEEMLEHAESAQDFASRAKLAVQKLVQKVGFFGILACASIPNP
LFDLAGITCGHFLVPFWTFFGATLIGKAIIKMHIQKIFVIITFSKHIVEQMVAFIGAVPGIGPSLQKPFQEYLEAQRQKLHHKSEMGTPQ

--------------------------------------------------------------

>58849_58849_5_NFE2L2-VMP1_NFE2L2_chr2_178129259_ENST00000397062_VMP1_chr17_57851114_ENST00000545362_length(amino acids)=227AA_BP=15
MMDLELPPPGLPSQQGIGTAIGELPPYFMARAARLSGAEPDDEEYQEFEEMLEHAESAQDFASRAKLAVQKLVQKVGFFGILACASIPNP
LFDLAGITCGHFLVPFWTFFGATLIGKAIIKMHIQKIFVIITFSKHIVEQMVAFIGAVPGIGPSLQKPFQEYLEAQRQKLHHKSEMGTPQ

--------------------------------------------------------------

>58849_58849_6_NFE2L2-VMP1_NFE2L2_chr2_178129259_ENST00000397062_VMP1_chr17_57886156_ENST00000262291_length(amino acids)=187AA_BP=154
MPLFAGEGKLNAGTGELTETSSRSPACWDPSWQSLPAPGPRASCVSPGAGGGFSEAQPARPAGEGRARTLAPPLWGGRRSGAGARRRVAD
YRVPGSPEEPPTQPPPPPPPPPEPPCPRRASAAGTGPPSGSPNTRSTAHHDGLGAAAAGTPVPAGLCLPGQTGSSKTSTESWIFWNFGLC

--------------------------------------------------------------

>58849_58849_7_NFE2L2-VMP1_NFE2L2_chr2_178129259_ENST00000397062_VMP1_chr17_57886156_ENST00000536180_length(amino acids)=187AA_BP=154
MPLFAGEGKLNAGTGELTETSSRSPACWDPSWQSLPAPGPRASCVSPGAGGGFSEAQPARPAGEGRARTLAPPLWGGRRSGAGARRRVAD
YRVPGSPEEPPTQPPPPPPPPPEPPCPRRASAAGTGPPSGSPNTRSTAHHDGLGAAAAGTPVPAGLCLPGQTGSSKTSTESWIFWNFGLC

--------------------------------------------------------------

>58849_58849_8_NFE2L2-VMP1_NFE2L2_chr2_178129259_ENST00000397062_VMP1_chr17_57886156_ENST00000537567_length(amino acids)=187AA_BP=154
MPLFAGEGKLNAGTGELTETSSRSPACWDPSWQSLPAPGPRASCVSPGAGGGFSEAQPARPAGEGRARTLAPPLWGGRRSGAGARRRVAD
YRVPGSPEEPPTQPPPPPPPPPEPPCPRRASAAGTGPPSGSPNTRSTAHHDGLGAAAAGTPVPAGLCLPGQTGSSKTSTESWIFWNFGLC

--------------------------------------------------------------

>58849_58849_9_NFE2L2-VMP1_NFE2L2_chr2_178129259_ENST00000397062_VMP1_chr17_57886156_ENST00000539763_length(amino acids)=187AA_BP=154
MPLFAGEGKLNAGTGELTETSSRSPACWDPSWQSLPAPGPRASCVSPGAGGGFSEAQPARPAGEGRARTLAPPLWGGRRSGAGARRRVAD
YRVPGSPEEPPTQPPPPPPPPPEPPCPRRASAAGTGPPSGSPNTRSTAHHDGLGAAAAGTPVPAGLCLPGQTGSSKTSTESWIFWNFGLC

--------------------------------------------------------------

>58849_58849_10_NFE2L2-VMP1_NFE2L2_chr2_178129259_ENST00000397062_VMP1_chr17_57886156_ENST00000545362_length(amino acids)=187AA_BP=154
MPLFAGEGKLNAGTGELTETSSRSPACWDPSWQSLPAPGPRASCVSPGAGGGFSEAQPARPAGEGRARTLAPPLWGGRRSGAGARRRVAD
YRVPGSPEEPPTQPPPPPPPPPEPPCPRRASAAGTGPPSGSPNTRSTAHHDGLGAAAAGTPVPAGLCLPGQTGSSKTSTESWIFWNFGLC

--------------------------------------------------------------

>58849_58849_11_NFE2L2-VMP1_NFE2L2_chr2_178129260_ENST00000397062_VMP1_chr17_57851115_ENST00000262291_length(amino acids)=227AA_BP=15
MMDLELPPPGLPSQQGIGTAIGELPPYFMARAARLSGAEPDDEEYQEFEEMLEHAESAQDFASRAKLAVQKLVQKVGFFGILACASIPNP
LFDLAGITCGHFLVPFWTFFGATLIGKAIIKMHIQKIFVIITFSKHIVEQMVAFIGAVPGIGPSLQKPFQEYLEAQRQKLHHKSEMGTPQ

--------------------------------------------------------------

>58849_58849_12_NFE2L2-VMP1_NFE2L2_chr2_178129260_ENST00000397062_VMP1_chr17_57851115_ENST00000536180_length(amino acids)=227AA_BP=15
MMDLELPPPGLPSQQGIGTAIGELPPYFMARAARLSGAEPDDEEYQEFEEMLEHAESAQDFASRAKLAVQKLVQKVGFFGILACASIPNP
LFDLAGITCGHFLVPFWTFFGATLIGKAIIKMHIQKIFVIITFSKHIVEQMVAFIGAVPGIGPSLQKPFQEYLEAQRQKLHHKSEMGTPQ

--------------------------------------------------------------

>58849_58849_13_NFE2L2-VMP1_NFE2L2_chr2_178129260_ENST00000397062_VMP1_chr17_57851115_ENST00000537567_length(amino acids)=227AA_BP=15
MMDLELPPPGLPSQQGIGTAIGELPPYFMARAARLSGAEPDDEEYQEFEEMLEHAESAQDFASRAKLAVQKLVQKVGFFGILACASIPNP
LFDLAGITCGHFLVPFWTFFGATLIGKAIIKMHIQKIFVIITFSKHIVEQMVAFIGAVPGIGPSLQKPFQEYLEAQRQKLHHKSEMGTPQ

--------------------------------------------------------------

>58849_58849_14_NFE2L2-VMP1_NFE2L2_chr2_178129260_ENST00000397062_VMP1_chr17_57851115_ENST00000539763_length(amino acids)=227AA_BP=15
MMDLELPPPGLPSQQGIGTAIGELPPYFMARAARLSGAEPDDEEYQEFEEMLEHAESAQDFASRAKLAVQKLVQKVGFFGILACASIPNP
LFDLAGITCGHFLVPFWTFFGATLIGKAIIKMHIQKIFVIITFSKHIVEQMVAFIGAVPGIGPSLQKPFQEYLEAQRQKLHHKSEMGTPQ

--------------------------------------------------------------

>58849_58849_15_NFE2L2-VMP1_NFE2L2_chr2_178129260_ENST00000397062_VMP1_chr17_57851115_ENST00000545362_length(amino acids)=227AA_BP=15
MMDLELPPPGLPSQQGIGTAIGELPPYFMARAARLSGAEPDDEEYQEFEEMLEHAESAQDFASRAKLAVQKLVQKVGFFGILACASIPNP
LFDLAGITCGHFLVPFWTFFGATLIGKAIIKMHIQKIFVIITFSKHIVEQMVAFIGAVPGIGPSLQKPFQEYLEAQRQKLHHKSEMGTPQ

--------------------------------------------------------------

>58849_58849_16_NFE2L2-VMP1_NFE2L2_chr2_178129260_ENST00000397062_VMP1_chr17_57886157_ENST00000262291_length(amino acids)=187AA_BP=154
MPLFAGEGKLNAGTGELTETSSRSPACWDPSWQSLPAPGPRASCVSPGAGGGFSEAQPARPAGEGRARTLAPPLWGGRRSGAGARRRVAD
YRVPGSPEEPPTQPPPPPPPPPEPPCPRRASAAGTGPPSGSPNTRSTAHHDGLGAAAAGTPVPAGLCLPGQTGSSKTSTESWIFWNFGLC

--------------------------------------------------------------

>58849_58849_17_NFE2L2-VMP1_NFE2L2_chr2_178129260_ENST00000397062_VMP1_chr17_57886157_ENST00000536180_length(amino acids)=187AA_BP=154
MPLFAGEGKLNAGTGELTETSSRSPACWDPSWQSLPAPGPRASCVSPGAGGGFSEAQPARPAGEGRARTLAPPLWGGRRSGAGARRRVAD
YRVPGSPEEPPTQPPPPPPPPPEPPCPRRASAAGTGPPSGSPNTRSTAHHDGLGAAAAGTPVPAGLCLPGQTGSSKTSTESWIFWNFGLC

--------------------------------------------------------------

>58849_58849_18_NFE2L2-VMP1_NFE2L2_chr2_178129260_ENST00000397062_VMP1_chr17_57886157_ENST00000537567_length(amino acids)=187AA_BP=154
MPLFAGEGKLNAGTGELTETSSRSPACWDPSWQSLPAPGPRASCVSPGAGGGFSEAQPARPAGEGRARTLAPPLWGGRRSGAGARRRVAD
YRVPGSPEEPPTQPPPPPPPPPEPPCPRRASAAGTGPPSGSPNTRSTAHHDGLGAAAAGTPVPAGLCLPGQTGSSKTSTESWIFWNFGLC

--------------------------------------------------------------

>58849_58849_19_NFE2L2-VMP1_NFE2L2_chr2_178129260_ENST00000397062_VMP1_chr17_57886157_ENST00000539763_length(amino acids)=187AA_BP=154
MPLFAGEGKLNAGTGELTETSSRSPACWDPSWQSLPAPGPRASCVSPGAGGGFSEAQPARPAGEGRARTLAPPLWGGRRSGAGARRRVAD
YRVPGSPEEPPTQPPPPPPPPPEPPCPRRASAAGTGPPSGSPNTRSTAHHDGLGAAAAGTPVPAGLCLPGQTGSSKTSTESWIFWNFGLC

--------------------------------------------------------------

>58849_58849_20_NFE2L2-VMP1_NFE2L2_chr2_178129260_ENST00000397062_VMP1_chr17_57886157_ENST00000545362_length(amino acids)=187AA_BP=154
MPLFAGEGKLNAGTGELTETSSRSPACWDPSWQSLPAPGPRASCVSPGAGGGFSEAQPARPAGEGRARTLAPPLWGGRRSGAGARRRVAD
YRVPGSPEEPPTQPPPPPPPPPEPPCPRRASAAGTGPPSGSPNTRSTAHHDGLGAAAAGTPVPAGLCLPGQTGSSKTSTESWIFWNFGLC

--------------------------------------------------------------

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr2:178129260/chr17:57851115)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
NFE2L2

Q16236

.
FUNCTION: Transcription factor that plays a key role in the response to oxidative stress: binds to antioxidant response (ARE) elements present in the promoter region of many cytoprotective genes, such as phase 2 detoxifying enzymes, and promotes their expression, thereby neutralizing reactive electrophiles (PubMed:11035812, PubMed:19489739, PubMed:29018201, PubMed:31398338). In normal conditions, ubiquitinated and degraded in the cytoplasm by the BCR(KEAP1) complex (PubMed:11035812, PubMed:15601839, PubMed:29018201). In response to oxidative stress, electrophile metabolites inhibit activity of the BCR(KEAP1) complex, promoting nuclear accumulation of NFE2L2/NRF2, heterodimerization with one of the small Maf proteins and binding to ARE elements of cytoprotective target genes (PubMed:19489739, PubMed:29590092). The NFE2L2/NRF2 pathway is also activated in response to selective autophagy: autophagy promotes interaction between KEAP1 and SQSTM1/p62 and subsequent inactivation of the BCR(KEAP1) complex, leading to NFE2L2/NRF2 nuclear accumulation and expression of cytoprotective genes (PubMed:20452972). May also be involved in the transcriptional activation of genes of the beta-globin cluster by mediating enhancer activity of hypersensitive site 2 of the beta-globin locus control region (PubMed:7937919). {ECO:0000269|PubMed:11035812, ECO:0000269|PubMed:15601839, ECO:0000269|PubMed:19489739, ECO:0000269|PubMed:20452972, ECO:0000269|PubMed:29018201, ECO:0000269|PubMed:29590092, ECO:0000269|PubMed:31398338, ECO:0000269|PubMed:7937919}.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneVMP1chr2:178129259chr17:57851114ENST00000262291512272_273194.0407.0Topological domainCytoplasmic
TgeneVMP1chr2:178129259chr17:57851114ENST00000262291512295_305194.0407.0Topological domainExtracellular
TgeneVMP1chr2:178129259chr17:57851114ENST00000262291512327_363194.0407.0Topological domainCytoplasmic
TgeneVMP1chr2:178129259chr17:57851114ENST00000262291512385_406194.0407.0Topological domainExtracellular
TgeneVMP1chr2:178129259chr17:57886156ENST00000262291612272_273238.0407.0Topological domainCytoplasmic
TgeneVMP1chr2:178129259chr17:57886156ENST00000262291612295_305238.0407.0Topological domainExtracellular
TgeneVMP1chr2:178129259chr17:57886156ENST00000262291612327_363238.0407.0Topological domainCytoplasmic
TgeneVMP1chr2:178129259chr17:57886156ENST00000262291612385_406238.0407.0Topological domainExtracellular
TgeneVMP1chr2:178129260chr17:57851115ENST00000262291512272_273194.0407.0Topological domainCytoplasmic
TgeneVMP1chr2:178129260chr17:57851115ENST00000262291512295_305194.0407.0Topological domainExtracellular
TgeneVMP1chr2:178129260chr17:57851115ENST00000262291512327_363194.0407.0Topological domainCytoplasmic
TgeneVMP1chr2:178129260chr17:57851115ENST00000262291512385_406194.0407.0Topological domainExtracellular
TgeneVMP1chr2:178129260chr17:57886157ENST00000262291612272_273238.0407.0Topological domainCytoplasmic
TgeneVMP1chr2:178129260chr17:57886157ENST00000262291612295_305238.0407.0Topological domainExtracellular
TgeneVMP1chr2:178129260chr17:57886157ENST00000262291612327_363238.0407.0Topological domainCytoplasmic
TgeneVMP1chr2:178129260chr17:57886157ENST00000262291612385_406238.0407.0Topological domainExtracellular
TgeneVMP1chr2:178129259chr17:57851114ENST00000262291512251_271194.0407.0TransmembraneHelical
TgeneVMP1chr2:178129259chr17:57851114ENST00000262291512274_294194.0407.0TransmembraneHelical
TgeneVMP1chr2:178129259chr17:57851114ENST00000262291512306_326194.0407.0TransmembraneHelical
TgeneVMP1chr2:178129259chr17:57851114ENST00000262291512364_384194.0407.0TransmembraneHelical
TgeneVMP1chr2:178129259chr17:57886156ENST00000262291612251_271238.0407.0TransmembraneHelical
TgeneVMP1chr2:178129259chr17:57886156ENST00000262291612274_294238.0407.0TransmembraneHelical
TgeneVMP1chr2:178129259chr17:57886156ENST00000262291612306_326238.0407.0TransmembraneHelical
TgeneVMP1chr2:178129259chr17:57886156ENST00000262291612364_384238.0407.0TransmembraneHelical
TgeneVMP1chr2:178129260chr17:57851115ENST00000262291512251_271194.0407.0TransmembraneHelical
TgeneVMP1chr2:178129260chr17:57851115ENST00000262291512274_294194.0407.0TransmembraneHelical
TgeneVMP1chr2:178129260chr17:57851115ENST00000262291512306_326194.0407.0TransmembraneHelical
TgeneVMP1chr2:178129260chr17:57851115ENST00000262291512364_384194.0407.0TransmembraneHelical
TgeneVMP1chr2:178129260chr17:57886157ENST00000262291612251_271238.0407.0TransmembraneHelical
TgeneVMP1chr2:178129260chr17:57886157ENST00000262291612274_294238.0407.0TransmembraneHelical
TgeneVMP1chr2:178129260chr17:57886157ENST00000262291612306_326238.0407.0TransmembraneHelical
TgeneVMP1chr2:178129260chr17:57886157ENST00000262291612364_384238.0407.0TransmembraneHelical

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneNFE2L2chr2:178129259chr17:57851114ENST00000397062-15497_56015.0606.0DomainbZIP
HgeneNFE2L2chr2:178129259chr17:57851114ENST00000397063-15497_5600590.0DomainbZIP
HgeneNFE2L2chr2:178129259chr17:57851114ENST00000446151-15497_5600583.0DomainbZIP
HgeneNFE2L2chr2:178129259chr17:57851114ENST00000464747-18497_5600590.0DomainbZIP
HgeneNFE2L2chr2:178129259chr17:57886156ENST00000397062-15497_56015.0606.0DomainbZIP
HgeneNFE2L2chr2:178129259chr17:57886156ENST00000397063-15497_5600590.0DomainbZIP
HgeneNFE2L2chr2:178129259chr17:57886156ENST00000446151-15497_5600583.0DomainbZIP
HgeneNFE2L2chr2:178129259chr17:57886156ENST00000464747-18497_5600590.0DomainbZIP
HgeneNFE2L2chr2:178129260chr17:57851115ENST00000397062-15497_56015.0606.0DomainbZIP
HgeneNFE2L2chr2:178129260chr17:57851115ENST00000397063-15497_5600590.0DomainbZIP
HgeneNFE2L2chr2:178129260chr17:57851115ENST00000446151-15497_5600583.0DomainbZIP
HgeneNFE2L2chr2:178129260chr17:57851115ENST00000464747-18497_5600590.0DomainbZIP
HgeneNFE2L2chr2:178129260chr17:57886157ENST00000397062-15497_56015.0606.0DomainbZIP
HgeneNFE2L2chr2:178129260chr17:57886157ENST00000397063-15497_5600590.0DomainbZIP
HgeneNFE2L2chr2:178129260chr17:57886157ENST00000446151-15497_5600583.0DomainbZIP
HgeneNFE2L2chr2:178129260chr17:57886157ENST00000464747-18497_5600590.0DomainbZIP
HgeneNFE2L2chr2:178129259chr17:57851114ENST00000397062-1529_3115.0606.0MotifDLG motif
HgeneNFE2L2chr2:178129259chr17:57851114ENST00000397063-1529_310590.0MotifDLG motif
HgeneNFE2L2chr2:178129259chr17:57851114ENST00000446151-1529_310583.0MotifDLG motif
HgeneNFE2L2chr2:178129259chr17:57851114ENST00000464747-1829_310590.0MotifDLG motif
HgeneNFE2L2chr2:178129259chr17:57886156ENST00000397062-1529_3115.0606.0MotifDLG motif
HgeneNFE2L2chr2:178129259chr17:57886156ENST00000397063-1529_310590.0MotifDLG motif
HgeneNFE2L2chr2:178129259chr17:57886156ENST00000446151-1529_310583.0MotifDLG motif
HgeneNFE2L2chr2:178129259chr17:57886156ENST00000464747-1829_310590.0MotifDLG motif
HgeneNFE2L2chr2:178129260chr17:57851115ENST00000397062-1529_3115.0606.0MotifDLG motif
HgeneNFE2L2chr2:178129260chr17:57851115ENST00000397063-1529_310590.0MotifDLG motif
HgeneNFE2L2chr2:178129260chr17:57851115ENST00000446151-1529_310583.0MotifDLG motif
HgeneNFE2L2chr2:178129260chr17:57851115ENST00000464747-1829_310590.0MotifDLG motif
HgeneNFE2L2chr2:178129260chr17:57886157ENST00000397062-1529_3115.0606.0MotifDLG motif
HgeneNFE2L2chr2:178129260chr17:57886157ENST00000397063-1529_310590.0MotifDLG motif
HgeneNFE2L2chr2:178129260chr17:57886157ENST00000446151-1529_310583.0MotifDLG motif
HgeneNFE2L2chr2:178129260chr17:57886157ENST00000464747-1829_310590.0MotifDLG motif
HgeneNFE2L2chr2:178129259chr17:57851114ENST00000397062-15499_51815.0606.0RegionBasic motif
HgeneNFE2L2chr2:178129259chr17:57851114ENST00000397062-15522_52915.0606.0RegionLeucine-zipper
HgeneNFE2L2chr2:178129259chr17:57851114ENST00000397063-15499_5180590.0RegionBasic motif
HgeneNFE2L2chr2:178129259chr17:57851114ENST00000397063-15522_5290590.0RegionLeucine-zipper
HgeneNFE2L2chr2:178129259chr17:57851114ENST00000446151-15499_5180583.0RegionBasic motif
HgeneNFE2L2chr2:178129259chr17:57851114ENST00000446151-15522_5290583.0RegionLeucine-zipper
HgeneNFE2L2chr2:178129259chr17:57851114ENST00000464747-18499_5180590.0RegionBasic motif
HgeneNFE2L2chr2:178129259chr17:57851114ENST00000464747-18522_5290590.0RegionLeucine-zipper
HgeneNFE2L2chr2:178129259chr17:57886156ENST00000397062-15499_51815.0606.0RegionBasic motif
HgeneNFE2L2chr2:178129259chr17:57886156ENST00000397062-15522_52915.0606.0RegionLeucine-zipper
HgeneNFE2L2chr2:178129259chr17:57886156ENST00000397063-15499_5180590.0RegionBasic motif
HgeneNFE2L2chr2:178129259chr17:57886156ENST00000397063-15522_5290590.0RegionLeucine-zipper
HgeneNFE2L2chr2:178129259chr17:57886156ENST00000446151-15499_5180583.0RegionBasic motif
HgeneNFE2L2chr2:178129259chr17:57886156ENST00000446151-15522_5290583.0RegionLeucine-zipper
HgeneNFE2L2chr2:178129259chr17:57886156ENST00000464747-18499_5180590.0RegionBasic motif
HgeneNFE2L2chr2:178129259chr17:57886156ENST00000464747-18522_5290590.0RegionLeucine-zipper
HgeneNFE2L2chr2:178129260chr17:57851115ENST00000397062-15499_51815.0606.0RegionBasic motif
HgeneNFE2L2chr2:178129260chr17:57851115ENST00000397062-15522_52915.0606.0RegionLeucine-zipper
HgeneNFE2L2chr2:178129260chr17:57851115ENST00000397063-15499_5180590.0RegionBasic motif
HgeneNFE2L2chr2:178129260chr17:57851115ENST00000397063-15522_5290590.0RegionLeucine-zipper
HgeneNFE2L2chr2:178129260chr17:57851115ENST00000446151-15499_5180583.0RegionBasic motif
HgeneNFE2L2chr2:178129260chr17:57851115ENST00000446151-15522_5290583.0RegionLeucine-zipper
HgeneNFE2L2chr2:178129260chr17:57851115ENST00000464747-18499_5180590.0RegionBasic motif
HgeneNFE2L2chr2:178129260chr17:57851115ENST00000464747-18522_5290590.0RegionLeucine-zipper
HgeneNFE2L2chr2:178129260chr17:57886157ENST00000397062-15499_51815.0606.0RegionBasic motif
HgeneNFE2L2chr2:178129260chr17:57886157ENST00000397062-15522_52915.0606.0RegionLeucine-zipper
HgeneNFE2L2chr2:178129260chr17:57886157ENST00000397063-15499_5180590.0RegionBasic motif
HgeneNFE2L2chr2:178129260chr17:57886157ENST00000397063-15522_5290590.0RegionLeucine-zipper
HgeneNFE2L2chr2:178129260chr17:57886157ENST00000446151-15499_5180583.0RegionBasic motif
HgeneNFE2L2chr2:178129260chr17:57886157ENST00000446151-15522_5290583.0RegionLeucine-zipper
HgeneNFE2L2chr2:178129260chr17:57886157ENST00000464747-18499_5180590.0RegionBasic motif
HgeneNFE2L2chr2:178129260chr17:57886157ENST00000464747-18522_5290590.0RegionLeucine-zipper
TgeneVMP1chr2:178129259chr17:57851114ENST00000262291512173_316194.0407.0RegionVTT domain
TgeneVMP1chr2:178129259chr17:57886156ENST00000262291612173_316238.0407.0RegionVTT domain
TgeneVMP1chr2:178129260chr17:57851115ENST00000262291512173_316194.0407.0RegionVTT domain
TgeneVMP1chr2:178129260chr17:57886157ENST00000262291612173_316238.0407.0RegionVTT domain
TgeneVMP1chr2:178129259chr17:57851114ENST00000262291512131_250194.0407.0Topological domainExtracellular
TgeneVMP1chr2:178129259chr17:57851114ENST000002622915122_43194.0407.0Topological domainCytoplasmic
TgeneVMP1chr2:178129259chr17:57851114ENST0000026229151265_77194.0407.0Topological domainExtracellular
TgeneVMP1chr2:178129259chr17:57851114ENST0000026229151299_109194.0407.0Topological domainCytoplasmic
TgeneVMP1chr2:178129259chr17:57886156ENST00000262291612131_250238.0407.0Topological domainExtracellular
TgeneVMP1chr2:178129259chr17:57886156ENST000002622916122_43238.0407.0Topological domainCytoplasmic
TgeneVMP1chr2:178129259chr17:57886156ENST0000026229161265_77238.0407.0Topological domainExtracellular
TgeneVMP1chr2:178129259chr17:57886156ENST0000026229161299_109238.0407.0Topological domainCytoplasmic
TgeneVMP1chr2:178129260chr17:57851115ENST00000262291512131_250194.0407.0Topological domainExtracellular
TgeneVMP1chr2:178129260chr17:57851115ENST000002622915122_43194.0407.0Topological domainCytoplasmic
TgeneVMP1chr2:178129260chr17:57851115ENST0000026229151265_77194.0407.0Topological domainExtracellular
TgeneVMP1chr2:178129260chr17:57851115ENST0000026229151299_109194.0407.0Topological domainCytoplasmic
TgeneVMP1chr2:178129260chr17:57886157ENST00000262291612131_250238.0407.0Topological domainExtracellular
TgeneVMP1chr2:178129260chr17:57886157ENST000002622916122_43238.0407.0Topological domainCytoplasmic
TgeneVMP1chr2:178129260chr17:57886157ENST0000026229161265_77238.0407.0Topological domainExtracellular
TgeneVMP1chr2:178129260chr17:57886157ENST0000026229161299_109238.0407.0Topological domainCytoplasmic
TgeneVMP1chr2:178129259chr17:57851114ENST00000262291512110_130194.0407.0TransmembraneHelical
TgeneVMP1chr2:178129259chr17:57851114ENST0000026229151244_64194.0407.0TransmembraneHelical
TgeneVMP1chr2:178129259chr17:57851114ENST0000026229151278_98194.0407.0TransmembraneHelical
TgeneVMP1chr2:178129259chr17:57886156ENST00000262291612110_130238.0407.0TransmembraneHelical
TgeneVMP1chr2:178129259chr17:57886156ENST0000026229161244_64238.0407.0TransmembraneHelical
TgeneVMP1chr2:178129259chr17:57886156ENST0000026229161278_98238.0407.0TransmembraneHelical
TgeneVMP1chr2:178129260chr17:57851115ENST00000262291512110_130194.0407.0TransmembraneHelical
TgeneVMP1chr2:178129260chr17:57851115ENST0000026229151244_64194.0407.0TransmembraneHelical
TgeneVMP1chr2:178129260chr17:57851115ENST0000026229151278_98194.0407.0TransmembraneHelical
TgeneVMP1chr2:178129260chr17:57886157ENST00000262291612110_130238.0407.0TransmembraneHelical
TgeneVMP1chr2:178129260chr17:57886157ENST0000026229161244_64238.0407.0TransmembraneHelical
TgeneVMP1chr2:178129260chr17:57886157ENST0000026229161278_98238.0407.0TransmembraneHelical


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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
NFE2L2
VMP1


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to NFE2L2-VMP1


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to NFE2L2-VMP1


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource