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Center for Computational Systems Medicine level1
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:NID1-HDAC5

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: NID1-HDAC5
FusionPDB ID: 59121
FusionGDB2.0 ID: 59121
HgeneTgene
Gene symbol

NID1

HDAC5

Gene ID

4811

10014

Gene namenidogen 1histone deacetylase 5
SynonymsNIDHD5|NY-CO-9
Cytomap

1q42.3

17q21.31

Type of geneprotein-codingprotein-coding
Descriptionnidogen-1NID-1enactinentactinepididymis secretory sperm binding proteinhistone deacetylase 5antigen NY-CO-9
Modification date2020031320200313
UniProtAcc

P14543

Q9UQL6

Ensembl transtripts involved in fusion geneENST idsENST00000264187, ENST00000366595, 
ENST00000225983, ENST00000336057, 
ENST00000393622, ENST00000586802, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score9 X 9 X 4=32413 X 11 X 8=1144
# samples 914
** MAII scorelog2(9/324*10)=-1.84799690655495
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(14/1144*10)=-3.03058831983342
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: NID1 [Title/Abstract] AND HDAC5 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)NID1(236148679)-HDAC5(42156645), # samples:1
Anticipated loss of major functional domain due to fusion event.NID1-HDAC5 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
NID1-HDAC5 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
NID1-HDAC5 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
NID1-HDAC5 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneHDAC5

GO:0000122

negative regulation of transcription by RNA polymerase II

16236793

TgeneHDAC5

GO:0016575

histone deacetylation

10869435


check buttonFusion gene breakpoints across NID1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across HDAC5 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4GBMTCGA-14-1402-02ANID1chr1

236148679

-HDAC5chr17

42156645

-


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000366595NID1chr1236148679-ENST00000225983HDAC5chr1742156645-474126863031101026
ENST00000366595NID1chr1236148679-ENST00000393622HDAC5chr1742156645-473426863031101026
ENST00000366595NID1chr1236148679-ENST00000336057HDAC5chr1742156645-473326863031101026
ENST00000366595NID1chr1236148679-ENST00000586802HDAC5chr1742156645-319326863031101026
ENST00000264187NID1chr1236148679-ENST00000225983HDAC5chr1742156645-51933138235621186
ENST00000264187NID1chr1236148679-ENST00000393622HDAC5chr1742156645-51863138235621186
ENST00000264187NID1chr1236148679-ENST00000336057HDAC5chr1742156645-51853138235621186
ENST00000264187NID1chr1236148679-ENST00000586802HDAC5chr1742156645-36453138235621186

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000366595ENST00000225983NID1chr1236148679-HDAC5chr1742156645-0.0006225020.99937755
ENST00000366595ENST00000393622NID1chr1236148679-HDAC5chr1742156645-0.0006293270.99937063
ENST00000366595ENST00000336057NID1chr1236148679-HDAC5chr1742156645-0.0006271730.9993729
ENST00000366595ENST00000586802NID1chr1236148679-HDAC5chr1742156645-0.0016161050.9983839
ENST00000264187ENST00000225983NID1chr1236148679-HDAC5chr1742156645-0.0005473650.99945265
ENST00000264187ENST00000393622NID1chr1236148679-HDAC5chr1742156645-0.000553420.9994466
ENST00000264187ENST00000336057NID1chr1236148679-HDAC5chr1742156645-0.0005514070.9994486
ENST00000264187ENST00000586802NID1chr1236148679-HDAC5chr1742156645-0.0013149040.99868506

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>59121_59121_1_NID1-HDAC5_NID1_chr1_236148679_ENST00000264187_HDAC5_chr17_42156645_ENST00000225983_length(amino acids)=1186AA_BP=1045
LPGASGYIPAFLCPGRGTGFAGPQFGNMLASSSRIRAAWTRALLLPLLLAGPVGCLSRQELFPFGPGQGDLELEDGDDFVSPALELSGAL
RFYDRSDIDAVYVTTNGIIATSEPPAKESHPGLFPPTFGAVAPFLADLDTTDGLGKVYYREDLSPSITQRAAECVHRGFPEISFQPSSAV
VVTWESVAPYQGPSRDPDQKGKRNTFQAVLASSDSSSYAIFLYPEDGLQFHTTFSKKENNQVPAVVAFSQGSVGFLWKSNGAYNIFANDR
ESVENLAKSSNSGQQGVWVFEIGSPATTNGVVPADVILGTEDGAEYDDEDEDYDLATTRLGLEDVGTTPFSYKALRRGGADTYSVPSVLS
PRRAATERPLGPPTERTRSFQLAVETFHQQHPQVIDVDEVEETGVVFSYNTDSRQTCANNRHQCSVHAECRDYATGFCCSCVAGYTGNGR
QCVAEGSPQRVNGKVKGRIFVGSSQVPIVFENTDLHSYVVMNHGRSYTAISTIPETVGYSLLPLAPVGGIIGWMFAVEQDGFKNGFSITG
GEFTRQAEVTFVGHPGNLVIKQRFSGIDEHGHLTIDTELEGRVPQIPFGSSVHIEPYTELYHYSTSVITSSSTREYTVTEPERDGASPSR
IYTYQWRQTITFQECVHDDSRPALPSTQQLSVDSVFVLYNQEEKILRYALSNSIGPVREGSPDALQNPCYIGTHGCDTNAACRPGPRTQF
TCECSIGFRGDGRTCYDIDECSEQPSVCGSHTICNNHPGTFRCECVEGYQFSDEGTCVAVVDQRPINYCETGLHNCDIPQRAQCIYTGGS
SYTCSCLPGFSGDGQACQDVDECQPSRCHPDAFCYNTPGSFTCQCKPGYQGDGFRCVPGEVEKTRCQHEREHILGAAGATDPQRPIPPGL
FVPECDAHGHYAPTQCHGSTGYCWCVDRDGREVEGTRTRPGMTPPCLSTVAPPIHQGPAVPTAVIPLPPGTHLLFAQTGKIERLPLEGNT
MRKTEAKAFLHVPAKVIIGLAFDCVDKMVYWTDITEPSIGRASLHGGEPTTIIRQGFGHLTRQLMTLAGGRVVLALEGGHDLTAICDASE
ACVSALLSVELQPLDEAVLQQKPNINAVATLEKVIEIQSKHWSCVQKFAAGLGRSLREAQAGETEEAETVSAMALLSVGAEQAQAAAARE

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>59121_59121_2_NID1-HDAC5_NID1_chr1_236148679_ENST00000264187_HDAC5_chr17_42156645_ENST00000336057_length(amino acids)=1186AA_BP=1045
LPGASGYIPAFLCPGRGTGFAGPQFGNMLASSSRIRAAWTRALLLPLLLAGPVGCLSRQELFPFGPGQGDLELEDGDDFVSPALELSGAL
RFYDRSDIDAVYVTTNGIIATSEPPAKESHPGLFPPTFGAVAPFLADLDTTDGLGKVYYREDLSPSITQRAAECVHRGFPEISFQPSSAV
VVTWESVAPYQGPSRDPDQKGKRNTFQAVLASSDSSSYAIFLYPEDGLQFHTTFSKKENNQVPAVVAFSQGSVGFLWKSNGAYNIFANDR
ESVENLAKSSNSGQQGVWVFEIGSPATTNGVVPADVILGTEDGAEYDDEDEDYDLATTRLGLEDVGTTPFSYKALRRGGADTYSVPSVLS
PRRAATERPLGPPTERTRSFQLAVETFHQQHPQVIDVDEVEETGVVFSYNTDSRQTCANNRHQCSVHAECRDYATGFCCSCVAGYTGNGR
QCVAEGSPQRVNGKVKGRIFVGSSQVPIVFENTDLHSYVVMNHGRSYTAISTIPETVGYSLLPLAPVGGIIGWMFAVEQDGFKNGFSITG
GEFTRQAEVTFVGHPGNLVIKQRFSGIDEHGHLTIDTELEGRVPQIPFGSSVHIEPYTELYHYSTSVITSSSTREYTVTEPERDGASPSR
IYTYQWRQTITFQECVHDDSRPALPSTQQLSVDSVFVLYNQEEKILRYALSNSIGPVREGSPDALQNPCYIGTHGCDTNAACRPGPRTQF
TCECSIGFRGDGRTCYDIDECSEQPSVCGSHTICNNHPGTFRCECVEGYQFSDEGTCVAVVDQRPINYCETGLHNCDIPQRAQCIYTGGS
SYTCSCLPGFSGDGQACQDVDECQPSRCHPDAFCYNTPGSFTCQCKPGYQGDGFRCVPGEVEKTRCQHEREHILGAAGATDPQRPIPPGL
FVPECDAHGHYAPTQCHGSTGYCWCVDRDGREVEGTRTRPGMTPPCLSTVAPPIHQGPAVPTAVIPLPPGTHLLFAQTGKIERLPLEGNT
MRKTEAKAFLHVPAKVIIGLAFDCVDKMVYWTDITEPSIGRASLHGGEPTTIIRQGFGHLTRQLMTLAGGRVVLALEGGHDLTAICDASE
ACVSALLSVELQPLDEAVLQQKPNINAVATLEKVIEIQSKHWSCVQKFAAGLGRSLREAQAGETEEAETVSAMALLSVGAEQAQAAAARE

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>59121_59121_3_NID1-HDAC5_NID1_chr1_236148679_ENST00000264187_HDAC5_chr17_42156645_ENST00000393622_length(amino acids)=1186AA_BP=1045
LPGASGYIPAFLCPGRGTGFAGPQFGNMLASSSRIRAAWTRALLLPLLLAGPVGCLSRQELFPFGPGQGDLELEDGDDFVSPALELSGAL
RFYDRSDIDAVYVTTNGIIATSEPPAKESHPGLFPPTFGAVAPFLADLDTTDGLGKVYYREDLSPSITQRAAECVHRGFPEISFQPSSAV
VVTWESVAPYQGPSRDPDQKGKRNTFQAVLASSDSSSYAIFLYPEDGLQFHTTFSKKENNQVPAVVAFSQGSVGFLWKSNGAYNIFANDR
ESVENLAKSSNSGQQGVWVFEIGSPATTNGVVPADVILGTEDGAEYDDEDEDYDLATTRLGLEDVGTTPFSYKALRRGGADTYSVPSVLS
PRRAATERPLGPPTERTRSFQLAVETFHQQHPQVIDVDEVEETGVVFSYNTDSRQTCANNRHQCSVHAECRDYATGFCCSCVAGYTGNGR
QCVAEGSPQRVNGKVKGRIFVGSSQVPIVFENTDLHSYVVMNHGRSYTAISTIPETVGYSLLPLAPVGGIIGWMFAVEQDGFKNGFSITG
GEFTRQAEVTFVGHPGNLVIKQRFSGIDEHGHLTIDTELEGRVPQIPFGSSVHIEPYTELYHYSTSVITSSSTREYTVTEPERDGASPSR
IYTYQWRQTITFQECVHDDSRPALPSTQQLSVDSVFVLYNQEEKILRYALSNSIGPVREGSPDALQNPCYIGTHGCDTNAACRPGPRTQF
TCECSIGFRGDGRTCYDIDECSEQPSVCGSHTICNNHPGTFRCECVEGYQFSDEGTCVAVVDQRPINYCETGLHNCDIPQRAQCIYTGGS
SYTCSCLPGFSGDGQACQDVDECQPSRCHPDAFCYNTPGSFTCQCKPGYQGDGFRCVPGEVEKTRCQHEREHILGAAGATDPQRPIPPGL
FVPECDAHGHYAPTQCHGSTGYCWCVDRDGREVEGTRTRPGMTPPCLSTVAPPIHQGPAVPTAVIPLPPGTHLLFAQTGKIERLPLEGNT
MRKTEAKAFLHVPAKVIIGLAFDCVDKMVYWTDITEPSIGRASLHGGEPTTIIRQGFGHLTRQLMTLAGGRVVLALEGGHDLTAICDASE
ACVSALLSVELQPLDEAVLQQKPNINAVATLEKVIEIQSKHWSCVQKFAAGLGRSLREAQAGETEEAETVSAMALLSVGAEQAQAAAARE

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>59121_59121_4_NID1-HDAC5_NID1_chr1_236148679_ENST00000264187_HDAC5_chr17_42156645_ENST00000586802_length(amino acids)=1186AA_BP=1045
LPGASGYIPAFLCPGRGTGFAGPQFGNMLASSSRIRAAWTRALLLPLLLAGPVGCLSRQELFPFGPGQGDLELEDGDDFVSPALELSGAL
RFYDRSDIDAVYVTTNGIIATSEPPAKESHPGLFPPTFGAVAPFLADLDTTDGLGKVYYREDLSPSITQRAAECVHRGFPEISFQPSSAV
VVTWESVAPYQGPSRDPDQKGKRNTFQAVLASSDSSSYAIFLYPEDGLQFHTTFSKKENNQVPAVVAFSQGSVGFLWKSNGAYNIFANDR
ESVENLAKSSNSGQQGVWVFEIGSPATTNGVVPADVILGTEDGAEYDDEDEDYDLATTRLGLEDVGTTPFSYKALRRGGADTYSVPSVLS
PRRAATERPLGPPTERTRSFQLAVETFHQQHPQVIDVDEVEETGVVFSYNTDSRQTCANNRHQCSVHAECRDYATGFCCSCVAGYTGNGR
QCVAEGSPQRVNGKVKGRIFVGSSQVPIVFENTDLHSYVVMNHGRSYTAISTIPETVGYSLLPLAPVGGIIGWMFAVEQDGFKNGFSITG
GEFTRQAEVTFVGHPGNLVIKQRFSGIDEHGHLTIDTELEGRVPQIPFGSSVHIEPYTELYHYSTSVITSSSTREYTVTEPERDGASPSR
IYTYQWRQTITFQECVHDDSRPALPSTQQLSVDSVFVLYNQEEKILRYALSNSIGPVREGSPDALQNPCYIGTHGCDTNAACRPGPRTQF
TCECSIGFRGDGRTCYDIDECSEQPSVCGSHTICNNHPGTFRCECVEGYQFSDEGTCVAVVDQRPINYCETGLHNCDIPQRAQCIYTGGS
SYTCSCLPGFSGDGQACQDVDECQPSRCHPDAFCYNTPGSFTCQCKPGYQGDGFRCVPGEVEKTRCQHEREHILGAAGATDPQRPIPPGL
FVPECDAHGHYAPTQCHGSTGYCWCVDRDGREVEGTRTRPGMTPPCLSTVAPPIHQGPAVPTAVIPLPPGTHLLFAQTGKIERLPLEGNT
MRKTEAKAFLHVPAKVIIGLAFDCVDKMVYWTDITEPSIGRASLHGGEPTTIIRQGFGHLTRQLMTLAGGRVVLALEGGHDLTAICDASE
ACVSALLSVELQPLDEAVLQQKPNINAVATLEKVIEIQSKHWSCVQKFAAGLGRSLREAQAGETEEAETVSAMALLSVGAEQAQAAAARE

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>59121_59121_5_NID1-HDAC5_NID1_chr1_236148679_ENST00000366595_HDAC5_chr17_42156645_ENST00000225983_length(amino acids)=1026AA_BP=885
MLASSSRIRAAWTRALLLPLLLAGPVGCLSRQELFPFGPGQGDLELEDGDDFVSPALELSGALRFYDRSDIDAVYVTTNGIIATSEPPAK
ESHPGLFPPTFGAVAPFLADLDTTDGLGKVYYREDLSPSITQRAAECVHRGFPEISFQPSSAVVVTWESVAPYQGPSRDPDQKGKRNTFQ
AVLASSDSSSYAIFLYPEDGLQFHTTFSKKENNQVPAVVAFSQGSVGFLWKSNGAYNIFANDRESVENLAKSSNSGQQGVWVFEIGSPAT
TNGVVPADVILGTEDGAEYDDEDEDYDLATTRLGLEDVGTTPFSYKALRRGGADTYSVPSVLSPRRAATERPLGPPTERTRSFQLAVETF
HQQHPQVIDVDEVEETGVVFSYNTDSRQTCANNRHQCSVHAECRDYATGFCCSCVAGYTGNGRQCVAEGSPQRVNGKVKGRIFVGSSQVP
IVFENTDLHSYVVMNHGRSYTAISTIPETVGYSLLPLAPVGGIIGWMFAVEQDGFKNGFSITGGEFTRQAEVTFVGHPGNLVIKQRFSGI
DEHGHLTIDTELEGRVPQIPFGSSVHIEPYTELYHYSTSVITSSSTREYTVTEPERDGASPSRIYTYQWRQTITFQECVHDDSRPALPST
QQLSVDSVFVLYNQEEKILRYALSNSIGPVREGSPDALQNPCYIGTHGCDTNAACRPGPRTQFTCECSIGFRGDGRTCYEVEKTRCQHER
EHILGAAGATDPQRPIPPGLFVPECDAHGHYAPTQCHGSTGYCWCVDRDGREVEGTRTRPGMTPPCLSTVAPPIHQGPAVPTAVIPLPPG
THLLFAQTGKIERLPLEGNTMRKTEAKAFLHVPAKVIIGLAFDCVDKMVYWTDITEPSIGRASLHGGEPTTIIRQGFGHLTRQLMTLAGG
RVVLALEGGHDLTAICDASEACVSALLSVELQPLDEAVLQQKPNINAVATLEKVIEIQSKHWSCVQKFAAGLGRSLREAQAGETEEAETV

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>59121_59121_6_NID1-HDAC5_NID1_chr1_236148679_ENST00000366595_HDAC5_chr17_42156645_ENST00000336057_length(amino acids)=1026AA_BP=885
MLASSSRIRAAWTRALLLPLLLAGPVGCLSRQELFPFGPGQGDLELEDGDDFVSPALELSGALRFYDRSDIDAVYVTTNGIIATSEPPAK
ESHPGLFPPTFGAVAPFLADLDTTDGLGKVYYREDLSPSITQRAAECVHRGFPEISFQPSSAVVVTWESVAPYQGPSRDPDQKGKRNTFQ
AVLASSDSSSYAIFLYPEDGLQFHTTFSKKENNQVPAVVAFSQGSVGFLWKSNGAYNIFANDRESVENLAKSSNSGQQGVWVFEIGSPAT
TNGVVPADVILGTEDGAEYDDEDEDYDLATTRLGLEDVGTTPFSYKALRRGGADTYSVPSVLSPRRAATERPLGPPTERTRSFQLAVETF
HQQHPQVIDVDEVEETGVVFSYNTDSRQTCANNRHQCSVHAECRDYATGFCCSCVAGYTGNGRQCVAEGSPQRVNGKVKGRIFVGSSQVP
IVFENTDLHSYVVMNHGRSYTAISTIPETVGYSLLPLAPVGGIIGWMFAVEQDGFKNGFSITGGEFTRQAEVTFVGHPGNLVIKQRFSGI
DEHGHLTIDTELEGRVPQIPFGSSVHIEPYTELYHYSTSVITSSSTREYTVTEPERDGASPSRIYTYQWRQTITFQECVHDDSRPALPST
QQLSVDSVFVLYNQEEKILRYALSNSIGPVREGSPDALQNPCYIGTHGCDTNAACRPGPRTQFTCECSIGFRGDGRTCYEVEKTRCQHER
EHILGAAGATDPQRPIPPGLFVPECDAHGHYAPTQCHGSTGYCWCVDRDGREVEGTRTRPGMTPPCLSTVAPPIHQGPAVPTAVIPLPPG
THLLFAQTGKIERLPLEGNTMRKTEAKAFLHVPAKVIIGLAFDCVDKMVYWTDITEPSIGRASLHGGEPTTIIRQGFGHLTRQLMTLAGG
RVVLALEGGHDLTAICDASEACVSALLSVELQPLDEAVLQQKPNINAVATLEKVIEIQSKHWSCVQKFAAGLGRSLREAQAGETEEAETV

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>59121_59121_7_NID1-HDAC5_NID1_chr1_236148679_ENST00000366595_HDAC5_chr17_42156645_ENST00000393622_length(amino acids)=1026AA_BP=885
MLASSSRIRAAWTRALLLPLLLAGPVGCLSRQELFPFGPGQGDLELEDGDDFVSPALELSGALRFYDRSDIDAVYVTTNGIIATSEPPAK
ESHPGLFPPTFGAVAPFLADLDTTDGLGKVYYREDLSPSITQRAAECVHRGFPEISFQPSSAVVVTWESVAPYQGPSRDPDQKGKRNTFQ
AVLASSDSSSYAIFLYPEDGLQFHTTFSKKENNQVPAVVAFSQGSVGFLWKSNGAYNIFANDRESVENLAKSSNSGQQGVWVFEIGSPAT
TNGVVPADVILGTEDGAEYDDEDEDYDLATTRLGLEDVGTTPFSYKALRRGGADTYSVPSVLSPRRAATERPLGPPTERTRSFQLAVETF
HQQHPQVIDVDEVEETGVVFSYNTDSRQTCANNRHQCSVHAECRDYATGFCCSCVAGYTGNGRQCVAEGSPQRVNGKVKGRIFVGSSQVP
IVFENTDLHSYVVMNHGRSYTAISTIPETVGYSLLPLAPVGGIIGWMFAVEQDGFKNGFSITGGEFTRQAEVTFVGHPGNLVIKQRFSGI
DEHGHLTIDTELEGRVPQIPFGSSVHIEPYTELYHYSTSVITSSSTREYTVTEPERDGASPSRIYTYQWRQTITFQECVHDDSRPALPST
QQLSVDSVFVLYNQEEKILRYALSNSIGPVREGSPDALQNPCYIGTHGCDTNAACRPGPRTQFTCECSIGFRGDGRTCYEVEKTRCQHER
EHILGAAGATDPQRPIPPGLFVPECDAHGHYAPTQCHGSTGYCWCVDRDGREVEGTRTRPGMTPPCLSTVAPPIHQGPAVPTAVIPLPPG
THLLFAQTGKIERLPLEGNTMRKTEAKAFLHVPAKVIIGLAFDCVDKMVYWTDITEPSIGRASLHGGEPTTIIRQGFGHLTRQLMTLAGG
RVVLALEGGHDLTAICDASEACVSALLSVELQPLDEAVLQQKPNINAVATLEKVIEIQSKHWSCVQKFAAGLGRSLREAQAGETEEAETV

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>59121_59121_8_NID1-HDAC5_NID1_chr1_236148679_ENST00000366595_HDAC5_chr17_42156645_ENST00000586802_length(amino acids)=1026AA_BP=885
MLASSSRIRAAWTRALLLPLLLAGPVGCLSRQELFPFGPGQGDLELEDGDDFVSPALELSGALRFYDRSDIDAVYVTTNGIIATSEPPAK
ESHPGLFPPTFGAVAPFLADLDTTDGLGKVYYREDLSPSITQRAAECVHRGFPEISFQPSSAVVVTWESVAPYQGPSRDPDQKGKRNTFQ
AVLASSDSSSYAIFLYPEDGLQFHTTFSKKENNQVPAVVAFSQGSVGFLWKSNGAYNIFANDRESVENLAKSSNSGQQGVWVFEIGSPAT
TNGVVPADVILGTEDGAEYDDEDEDYDLATTRLGLEDVGTTPFSYKALRRGGADTYSVPSVLSPRRAATERPLGPPTERTRSFQLAVETF
HQQHPQVIDVDEVEETGVVFSYNTDSRQTCANNRHQCSVHAECRDYATGFCCSCVAGYTGNGRQCVAEGSPQRVNGKVKGRIFVGSSQVP
IVFENTDLHSYVVMNHGRSYTAISTIPETVGYSLLPLAPVGGIIGWMFAVEQDGFKNGFSITGGEFTRQAEVTFVGHPGNLVIKQRFSGI
DEHGHLTIDTELEGRVPQIPFGSSVHIEPYTELYHYSTSVITSSSTREYTVTEPERDGASPSRIYTYQWRQTITFQECVHDDSRPALPST
QQLSVDSVFVLYNQEEKILRYALSNSIGPVREGSPDALQNPCYIGTHGCDTNAACRPGPRTQFTCECSIGFRGDGRTCYEVEKTRCQHER
EHILGAAGATDPQRPIPPGLFVPECDAHGHYAPTQCHGSTGYCWCVDRDGREVEGTRTRPGMTPPCLSTVAPPIHQGPAVPTAVIPLPPG
THLLFAQTGKIERLPLEGNTMRKTEAKAFLHVPAKVIIGLAFDCVDKMVYWTDITEPSIGRASLHGGEPTTIIRQGFGHLTRQLMTLAGG
RVVLALEGGHDLTAICDASEACVSALLSVELQPLDEAVLQQKPNINAVATLEKVIEIQSKHWSCVQKFAAGLGRSLREAQAGETEEAETV

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr1:236148679/chr17:42156645)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
NID1

P14543

HDAC5

Q9UQL6

FUNCTION: Sulfated glycoprotein widely distributed in basement membranes and tightly associated with laminin. Also binds to collagen IV and perlecan. It probably has a role in cell-extracellular matrix interactions.FUNCTION: Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Involved in muscle maturation by repressing transcription of myocyte enhancer MEF2C. During muscle differentiation, it shuttles into the cytoplasm, allowing the expression of myocyte enhancer factors. Involved in the MTA1-mediated epigenetic regulation of ESR1 expression in breast cancer. Serves as a corepressor of RARA and causes its deacetylation (PubMed:28167758). In association with RARA, plays a role in the repression of microRNA-10a and thereby in the inflammatory response (PubMed:28167758). {ECO:0000269|PubMed:24413532, ECO:0000269|PubMed:28167758}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneNID1chr1:236148679chr17:42156645ENST00000264187-1520106_2681018.33333333333341248.0DomainNIDO
HgeneNID1chr1:236148679chr17:42156645ENST00000264187-1520386_4261018.33333333333341248.0DomainEGF-like 1
HgeneNID1chr1:236148679chr17:42156645ENST00000264187-1520430_6671018.33333333333341248.0DomainNidogen G2 beta-barrel
HgeneNID1chr1:236148679chr17:42156645ENST00000264187-1520668_7091018.33333333333341248.0DomainEGF-like 2
HgeneNID1chr1:236148679chr17:42156645ENST00000264187-1520710_7511018.33333333333341248.0DomainEGF-like 3%3B calcium-binding
HgeneNID1chr1:236148679chr17:42156645ENST00000264187-1520758_8011018.33333333333341248.0DomainEGF-like 4
HgeneNID1chr1:236148679chr17:42156645ENST00000264187-1520802_8401018.33333333333341248.0DomainEGF-like 5%3B calcium-binding
HgeneNID1chr1:236148679chr17:42156645ENST00000264187-1520846_9191018.33333333333341248.0DomainThyroglobulin type-1
HgeneNID1chr1:236148679chr17:42156645ENST00000366595-1217106_268885.33333333333341115.0DomainNIDO
HgeneNID1chr1:236148679chr17:42156645ENST00000366595-1217386_426885.33333333333341115.0DomainEGF-like 1
HgeneNID1chr1:236148679chr17:42156645ENST00000366595-1217430_667885.33333333333341115.0DomainNidogen G2 beta-barrel
HgeneNID1chr1:236148679chr17:42156645ENST00000366595-1217668_709885.33333333333341115.0DomainEGF-like 2
HgeneNID1chr1:236148679chr17:42156645ENST00000366595-1217710_751885.33333333333341115.0DomainEGF-like 3%3B calcium-binding
HgeneNID1chr1:236148679chr17:42156645ENST00000366595-1217758_801885.33333333333341115.0DomainEGF-like 4
HgeneNID1chr1:236148679chr17:42156645ENST00000366595-1217802_840885.33333333333341115.0DomainEGF-like 5%3B calcium-binding
HgeneNID1chr1:236148679chr17:42156645ENST00000264187-1520702_7041018.33333333333341248.0MotifNote=Cell attachment site
HgeneNID1chr1:236148679chr17:42156645ENST00000366595-1217702_704885.33333333333341115.0MotifNote=Cell attachment site
TgeneHDAC5chr1:236148679chr17:42156645ENST0000022598322271099_1104982.33333333333341124.0Compositional biasNote=Poly-Ala
TgeneHDAC5chr1:236148679chr17:42156645ENST0000033605720251099_1104896.33333333333341038.0Compositional biasNote=Poly-Ala
TgeneHDAC5chr1:236148679chr17:42156645ENST0000039362222271099_1104981.33333333333341123.0Compositional biasNote=Poly-Ala
TgeneHDAC5chr1:236148679chr17:42156645ENST0000058680222271099_1104981.33333333333341123.0Compositional biasNote=Poly-Ala
TgeneHDAC5chr1:236148679chr17:42156645ENST0000022598322271081_1122982.33333333333341124.0MotifNote=Nuclear export signal
TgeneHDAC5chr1:236148679chr17:42156645ENST0000033605720251081_1122896.33333333333341038.0MotifNote=Nuclear export signal
TgeneHDAC5chr1:236148679chr17:42156645ENST0000039362222271081_1122981.33333333333341123.0MotifNote=Nuclear export signal
TgeneHDAC5chr1:236148679chr17:42156645ENST0000058680222271081_1122981.33333333333341123.0MotifNote=Nuclear export signal

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneNID1chr1:236148679chr17:42156645ENST00000264187-15201208_12441018.33333333333341248.0DomainEGF-like 6
HgeneNID1chr1:236148679chr17:42156645ENST00000366595-12171208_1244885.33333333333341115.0DomainEGF-like 6
HgeneNID1chr1:236148679chr17:42156645ENST00000366595-1217846_919885.33333333333341115.0DomainThyroglobulin type-1
HgeneNID1chr1:236148679chr17:42156645ENST00000264187-15201033_10751018.33333333333341248.0RepeatNote=LDL-receptor class B 2
HgeneNID1chr1:236148679chr17:42156645ENST00000264187-15201076_11201018.33333333333341248.0RepeatNote=LDL-receptor class B 3
HgeneNID1chr1:236148679chr17:42156645ENST00000264187-15201121_11621018.33333333333341248.0RepeatNote=LDL-receptor class B 4
HgeneNID1chr1:236148679chr17:42156645ENST00000264187-1520990_10321018.33333333333341248.0RepeatNote=LDL-receptor class B 1
HgeneNID1chr1:236148679chr17:42156645ENST00000366595-12171033_1075885.33333333333341115.0RepeatNote=LDL-receptor class B 2
HgeneNID1chr1:236148679chr17:42156645ENST00000366595-12171076_1120885.33333333333341115.0RepeatNote=LDL-receptor class B 3
HgeneNID1chr1:236148679chr17:42156645ENST00000366595-12171121_1162885.33333333333341115.0RepeatNote=LDL-receptor class B 4
HgeneNID1chr1:236148679chr17:42156645ENST00000366595-1217990_1032885.33333333333341115.0RepeatNote=LDL-receptor class B 1
TgeneHDAC5chr1:236148679chr17:42156645ENST00000225983222747_52982.33333333333341124.0Compositional biasNote=Poly-Gly
TgeneHDAC5chr1:236148679chr17:42156645ENST000002259832227596_599982.33333333333341124.0Compositional biasNote=Poly-Glu
TgeneHDAC5chr1:236148679chr17:42156645ENST00000225983222785_92982.33333333333341124.0Compositional biasNote=Poly-Gln
TgeneHDAC5chr1:236148679chr17:42156645ENST00000336057202547_52896.33333333333341038.0Compositional biasNote=Poly-Gly
TgeneHDAC5chr1:236148679chr17:42156645ENST000003360572025596_599896.33333333333341038.0Compositional biasNote=Poly-Glu
TgeneHDAC5chr1:236148679chr17:42156645ENST00000336057202585_92896.33333333333341038.0Compositional biasNote=Poly-Gln
TgeneHDAC5chr1:236148679chr17:42156645ENST00000393622222747_52981.33333333333341123.0Compositional biasNote=Poly-Gly
TgeneHDAC5chr1:236148679chr17:42156645ENST000003936222227596_599981.33333333333341123.0Compositional biasNote=Poly-Glu
TgeneHDAC5chr1:236148679chr17:42156645ENST00000393622222785_92981.33333333333341123.0Compositional biasNote=Poly-Gln
TgeneHDAC5chr1:236148679chr17:42156645ENST00000586802222747_52981.33333333333341123.0Compositional biasNote=Poly-Gly
TgeneHDAC5chr1:236148679chr17:42156645ENST000005868022227596_599981.33333333333341123.0Compositional biasNote=Poly-Glu
TgeneHDAC5chr1:236148679chr17:42156645ENST00000586802222785_92981.33333333333341123.0Compositional biasNote=Poly-Gln
TgeneHDAC5chr1:236148679chr17:42156645ENST000002259832227684_1028982.33333333333341124.0RegionNote=Histone deacetylase
TgeneHDAC5chr1:236148679chr17:42156645ENST000003360572025684_1028896.33333333333341038.0RegionNote=Histone deacetylase
TgeneHDAC5chr1:236148679chr17:42156645ENST000003936222227684_1028981.33333333333341123.0RegionNote=Histone deacetylase
TgeneHDAC5chr1:236148679chr17:42156645ENST000005868022227684_1028981.33333333333341123.0RegionNote=Histone deacetylase


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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
NID1
HDAC5


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to NID1-HDAC5


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to NID1-HDAC5


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource