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Center for Computational Systems Medicine level1
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:NIN-CASP10

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: NIN-CASP10
FusionPDB ID: 59143
FusionGDB2.0 ID: 59143
HgeneTgene
Gene symbol

NIN

CASP10

Gene ID

51199

843

Gene namenineincaspase 10
SynonymsSCKL7ALPS2|FLICE2|MCH4
Cytomap

14q22.1

2q33.1

Type of geneprotein-codingprotein-coding
Descriptionnineinglycogen synthase kinase 3 beta-interacting proteinhNineinninein (GSK3B interacting protein)ninein centrosomal proteincaspase-10CASP-10FADD-like ICE2FAS-associated death domain protein interleukin-1B-converting enzyme 2ICE-like apoptotic protease 4apoptotic protease MCH-4caspase 10 apoptosis-related cysteine peptidasecaspase 10, apoptosis-related cysteine protease
Modification date2020032820200313
UniProtAcc

Q9Y2I6

Q92851

Ensembl transtripts involved in fusion geneENST idsENST00000245441, ENST00000324330, 
ENST00000382041, ENST00000382043, 
ENST00000389868, ENST00000453196, 
ENST00000530997, ENST00000486200, 
ENST00000492363, ENST00000313728, 
ENST00000346817, ENST00000374650, 
ENST00000448480, ENST00000360132, 
ENST00000272879, ENST00000286186, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score16 X 18 X 9=25925 X 3 X 3=45
# samples 204
** MAII scorelog2(20/2592*10)=-3.6959938131099
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(4/45*10)=-0.169925001442312
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: NIN [Title/Abstract] AND CASP10 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)NIN(51239019)-CASP10(202072798), # samples:1
Anticipated loss of major functional domain due to fusion event.NIN-CASP10 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
NIN-CASP10 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
NIN-CASP10 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
NIN-CASP10 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
NIN-CASP10 seems lost the major protein functional domain in Hgene partner, which is a CGC due to the frame-shifted ORF.
NIN-CASP10 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
NIN-CASP10 seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across NIN (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across CASP10 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4STADTCGA-BR-8078-01ANINchr14

51239019

-CASP10chr2

202072798

+


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000245441NINchr1451239019-ENST00000286186CASP10chr2202072798+585211721311927598
ENST00000245441NINchr1451239019-ENST00000272879CASP10chr2202072798+224811721311924597
ENST00000389868NINchr1451239019-ENST00000286186CASP10chr2202072798+585211721311927598
ENST00000389868NINchr1451239019-ENST00000272879CASP10chr2202072798+224811721311924597
ENST00000530997NINchr1451239019-ENST00000286186CASP10chr2202072798+566198101736578
ENST00000530997NINchr1451239019-ENST00000272879CASP10chr2202072798+205798101733577
ENST00000382041NINchr1451239019-ENST00000286186CASP10chr2202072798+585211721311927598
ENST00000382041NINchr1451239019-ENST00000272879CASP10chr2202072798+224811721311924597
ENST00000324330NINchr1451239019-ENST00000286186CASP10chr2202072798+585211721311927598
ENST00000324330NINchr1451239019-ENST00000272879CASP10chr2202072798+224811721311924597
ENST00000453196NINchr1451239019-ENST00000286186CASP10chr2202072798+585211721311927598
ENST00000453196NINchr1451239019-ENST00000272879CASP10chr2202072798+224811721311924597

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000245441ENST00000286186NINchr1451239019-CASP10chr2202072798+0.0005684740.99943155
ENST00000245441ENST00000272879NINchr1451239019-CASP10chr2202072798+0.0021852730.99781466
ENST00000389868ENST00000286186NINchr1451239019-CASP10chr2202072798+0.0005684740.99943155
ENST00000389868ENST00000272879NINchr1451239019-CASP10chr2202072798+0.0021852730.99781466
ENST00000530997ENST00000286186NINchr1451239019-CASP10chr2202072798+0.0004788670.99952114
ENST00000530997ENST00000272879NINchr1451239019-CASP10chr2202072798+0.0015681890.99843174
ENST00000382041ENST00000286186NINchr1451239019-CASP10chr2202072798+0.0005684740.99943155
ENST00000382041ENST00000272879NINchr1451239019-CASP10chr2202072798+0.0021852730.99781466
ENST00000324330ENST00000286186NINchr1451239019-CASP10chr2202072798+0.0005684740.99943155
ENST00000324330ENST00000272879NINchr1451239019-CASP10chr2202072798+0.0021852730.99781466
ENST00000453196ENST00000286186NINchr1451239019-CASP10chr2202072798+0.0005684740.99943155
ENST00000453196ENST00000272879NINchr1451239019-CASP10chr2202072798+0.0021852730.99781466

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>59143_59143_1_NIN-CASP10_NIN_chr14_51239019_ENST00000245441_CASP10_chr2_202072798_ENST00000272879_length(amino acids)=597AA_BP=341
MPAVRALRRDRQKVSTVGYGMDEVEQDQHEARLKELFDSFDTTGTGSLGQEELTDLCHMLSLEEVAPVLQQTLLQDNLLGRVHFDQFKEA
LILILSRTLSNEEHFQEPDCSLEAQPKYVRGGKRYGRRSLPEFQESVEEFPEVTVIEPLDEEARPSHIPAGDCSEHWKTQRSEEYEAEGQ
LRFWNPDDLNASQSGSSPPQDWIEEKLQEVCEDLGITRDGHLNRKKLVSICEQYGLQNVDGEMLEEVFHNLDPDGTMSVEDFFYGLFKNG
KSLTPSASTPYRQLKRHLSMQSFDESGRRTTTSSAMTSTIGFRVFSCLDDGMGHASVERILDTWQEEGIENSQEILKRAAVYRMNRNHRG
LCVIVNNHSFTSLKDRQGTHKDAEILSHVFQWLGFTVHIHNNVTKVEMEMVLQKQKCNPAHADGDCFVFCILTHGRFGAVYSSDEALIPI
REIMSHFTALQCPRLAEKPKLFFIQACQGEEIQPSVSIEADALNPEQAPTSLQDSIPAEADFLLGLATVPGYVSFRHVEEGSWYIQSLCN

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>59143_59143_2_NIN-CASP10_NIN_chr14_51239019_ENST00000245441_CASP10_chr2_202072798_ENST00000286186_length(amino acids)=598AA_BP=341
MPAVRALRRDRQKVSTVGYGMDEVEQDQHEARLKELFDSFDTTGTGSLGQEELTDLCHMLSLEEVAPVLQQTLLQDNLLGRVHFDQFKEA
LILILSRTLSNEEHFQEPDCSLEAQPKYVRGGKRYGRRSLPEFQESVEEFPEVTVIEPLDEEARPSHIPAGDCSEHWKTQRSEEYEAEGQ
LRFWNPDDLNASQSGSSPPQDWIEEKLQEVCEDLGITRDGHLNRKKLVSICEQYGLQNVDGEMLEEVFHNLDPDGTMSVEDFFYGLFKNG
KSLTPSASTPYRQLKRHLSMQSFDESGRRTTTSSAMTSTIGFRVFSCLDDGMGHASVERILDTWQEEGIENSQEILKRAAVYRMNRNHRG
LCVIVNNHSFTSLKDRQGTHKDAEILSHVFQWLGFTVHIHNNVTKVEMEMVLQKQKCNPAHADGDCFVFCILTHGRFGAVYSSDEALIPI
REIMSHFTALQCPRLAEKPKLFFIQACQGEEIQPSVSIEADALNPEQAPTSLQDSIPAEADFLLGLATVPGYVSFRHVEEGSWYIQSLCN

--------------------------------------------------------------

>59143_59143_3_NIN-CASP10_NIN_chr14_51239019_ENST00000324330_CASP10_chr2_202072798_ENST00000272879_length(amino acids)=597AA_BP=341
MPAVRALRRDRQKVSTVGYGMDEVEQDQHEARLKELFDSFDTTGTGSLGQEELTDLCHMLSLEEVAPVLQQTLLQDNLLGRVHFDQFKEA
LILILSRTLSNEEHFQEPDCSLEAQPKYVRGGKRYGRRSLPEFQESVEEFPEVTVIEPLDEEARPSHIPAGDCSEHWKTQRSEEYEAEGQ
LRFWNPDDLNASQSGSSPPQDWIEEKLQEVCEDLGITRDGHLNRKKLVSICEQYGLQNVDGEMLEEVFHNLDPDGTMSVEDFFYGLFKNG
KSLTPSASTPYRQLKRHLSMQSFDESGRRTTTSSAMTSTIGFRVFSCLDDGMGHASVERILDTWQEEGIENSQEILKRAAVYRMNRNHRG
LCVIVNNHSFTSLKDRQGTHKDAEILSHVFQWLGFTVHIHNNVTKVEMEMVLQKQKCNPAHADGDCFVFCILTHGRFGAVYSSDEALIPI
REIMSHFTALQCPRLAEKPKLFFIQACQGEEIQPSVSIEADALNPEQAPTSLQDSIPAEADFLLGLATVPGYVSFRHVEEGSWYIQSLCN

--------------------------------------------------------------

>59143_59143_4_NIN-CASP10_NIN_chr14_51239019_ENST00000324330_CASP10_chr2_202072798_ENST00000286186_length(amino acids)=598AA_BP=341
MPAVRALRRDRQKVSTVGYGMDEVEQDQHEARLKELFDSFDTTGTGSLGQEELTDLCHMLSLEEVAPVLQQTLLQDNLLGRVHFDQFKEA
LILILSRTLSNEEHFQEPDCSLEAQPKYVRGGKRYGRRSLPEFQESVEEFPEVTVIEPLDEEARPSHIPAGDCSEHWKTQRSEEYEAEGQ
LRFWNPDDLNASQSGSSPPQDWIEEKLQEVCEDLGITRDGHLNRKKLVSICEQYGLQNVDGEMLEEVFHNLDPDGTMSVEDFFYGLFKNG
KSLTPSASTPYRQLKRHLSMQSFDESGRRTTTSSAMTSTIGFRVFSCLDDGMGHASVERILDTWQEEGIENSQEILKRAAVYRMNRNHRG
LCVIVNNHSFTSLKDRQGTHKDAEILSHVFQWLGFTVHIHNNVTKVEMEMVLQKQKCNPAHADGDCFVFCILTHGRFGAVYSSDEALIPI
REIMSHFTALQCPRLAEKPKLFFIQACQGEEIQPSVSIEADALNPEQAPTSLQDSIPAEADFLLGLATVPGYVSFRHVEEGSWYIQSLCN

--------------------------------------------------------------

>59143_59143_5_NIN-CASP10_NIN_chr14_51239019_ENST00000382041_CASP10_chr2_202072798_ENST00000272879_length(amino acids)=597AA_BP=341
MPAVRALRRDRQKVSTVGYGMDEVEQDQHEARLKELFDSFDTTGTGSLGQEELTDLCHMLSLEEVAPVLQQTLLQDNLLGRVHFDQFKEA
LILILSRTLSNEEHFQEPDCSLEAQPKYVRGGKRYGRRSLPEFQESVEEFPEVTVIEPLDEEARPSHIPAGDCSEHWKTQRSEEYEAEGQ
LRFWNPDDLNASQSGSSPPQDWIEEKLQEVCEDLGITRDGHLNRKKLVSICEQYGLQNVDGEMLEEVFHNLDPDGTMSVEDFFYGLFKNG
KSLTPSASTPYRQLKRHLSMQSFDESGRRTTTSSAMTSTIGFRVFSCLDDGMGHASVERILDTWQEEGIENSQEILKRAAVYRMNRNHRG
LCVIVNNHSFTSLKDRQGTHKDAEILSHVFQWLGFTVHIHNNVTKVEMEMVLQKQKCNPAHADGDCFVFCILTHGRFGAVYSSDEALIPI
REIMSHFTALQCPRLAEKPKLFFIQACQGEEIQPSVSIEADALNPEQAPTSLQDSIPAEADFLLGLATVPGYVSFRHVEEGSWYIQSLCN

--------------------------------------------------------------

>59143_59143_6_NIN-CASP10_NIN_chr14_51239019_ENST00000382041_CASP10_chr2_202072798_ENST00000286186_length(amino acids)=598AA_BP=341
MPAVRALRRDRQKVSTVGYGMDEVEQDQHEARLKELFDSFDTTGTGSLGQEELTDLCHMLSLEEVAPVLQQTLLQDNLLGRVHFDQFKEA
LILILSRTLSNEEHFQEPDCSLEAQPKYVRGGKRYGRRSLPEFQESVEEFPEVTVIEPLDEEARPSHIPAGDCSEHWKTQRSEEYEAEGQ
LRFWNPDDLNASQSGSSPPQDWIEEKLQEVCEDLGITRDGHLNRKKLVSICEQYGLQNVDGEMLEEVFHNLDPDGTMSVEDFFYGLFKNG
KSLTPSASTPYRQLKRHLSMQSFDESGRRTTTSSAMTSTIGFRVFSCLDDGMGHASVERILDTWQEEGIENSQEILKRAAVYRMNRNHRG
LCVIVNNHSFTSLKDRQGTHKDAEILSHVFQWLGFTVHIHNNVTKVEMEMVLQKQKCNPAHADGDCFVFCILTHGRFGAVYSSDEALIPI
REIMSHFTALQCPRLAEKPKLFFIQACQGEEIQPSVSIEADALNPEQAPTSLQDSIPAEADFLLGLATVPGYVSFRHVEEGSWYIQSLCN

--------------------------------------------------------------

>59143_59143_7_NIN-CASP10_NIN_chr14_51239019_ENST00000389868_CASP10_chr2_202072798_ENST00000272879_length(amino acids)=597AA_BP=341
MPAVRALRRDRQKVSTVGYGMDEVEQDQHEARLKELFDSFDTTGTGSLGQEELTDLCHMLSLEEVAPVLQQTLLQDNLLGRVHFDQFKEA
LILILSRTLSNEEHFQEPDCSLEAQPKYVRGGKRYGRRSLPEFQESVEEFPEVTVIEPLDEEARPSHIPAGDCSEHWKTQRSEEYEAEGQ
LRFWNPDDLNASQSGSSPPQDWIEEKLQEVCEDLGITRDGHLNRKKLVSICEQYGLQNVDGEMLEEVFHNLDPDGTMSVEDFFYGLFKNG
KSLTPSASTPYRQLKRHLSMQSFDESGRRTTTSSAMTSTIGFRVFSCLDDGMGHASVERILDTWQEEGIENSQEILKRAAVYRMNRNHRG
LCVIVNNHSFTSLKDRQGTHKDAEILSHVFQWLGFTVHIHNNVTKVEMEMVLQKQKCNPAHADGDCFVFCILTHGRFGAVYSSDEALIPI
REIMSHFTALQCPRLAEKPKLFFIQACQGEEIQPSVSIEADALNPEQAPTSLQDSIPAEADFLLGLATVPGYVSFRHVEEGSWYIQSLCN

--------------------------------------------------------------

>59143_59143_8_NIN-CASP10_NIN_chr14_51239019_ENST00000389868_CASP10_chr2_202072798_ENST00000286186_length(amino acids)=598AA_BP=341
MPAVRALRRDRQKVSTVGYGMDEVEQDQHEARLKELFDSFDTTGTGSLGQEELTDLCHMLSLEEVAPVLQQTLLQDNLLGRVHFDQFKEA
LILILSRTLSNEEHFQEPDCSLEAQPKYVRGGKRYGRRSLPEFQESVEEFPEVTVIEPLDEEARPSHIPAGDCSEHWKTQRSEEYEAEGQ
LRFWNPDDLNASQSGSSPPQDWIEEKLQEVCEDLGITRDGHLNRKKLVSICEQYGLQNVDGEMLEEVFHNLDPDGTMSVEDFFYGLFKNG
KSLTPSASTPYRQLKRHLSMQSFDESGRRTTTSSAMTSTIGFRVFSCLDDGMGHASVERILDTWQEEGIENSQEILKRAAVYRMNRNHRG
LCVIVNNHSFTSLKDRQGTHKDAEILSHVFQWLGFTVHIHNNVTKVEMEMVLQKQKCNPAHADGDCFVFCILTHGRFGAVYSSDEALIPI
REIMSHFTALQCPRLAEKPKLFFIQACQGEEIQPSVSIEADALNPEQAPTSLQDSIPAEADFLLGLATVPGYVSFRHVEEGSWYIQSLCN

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>59143_59143_9_NIN-CASP10_NIN_chr14_51239019_ENST00000453196_CASP10_chr2_202072798_ENST00000272879_length(amino acids)=597AA_BP=341
MPAVRALRRDRQKVSTVGYGMDEVEQDQHEARLKELFDSFDTTGTGSLGQEELTDLCHMLSLEEVAPVLQQTLLQDNLLGRVHFDQFKEA
LILILSRTLSNEEHFQEPDCSLEAQPKYVRGGKRYGRRSLPEFQESVEEFPEVTVIEPLDEEARPSHIPAGDCSEHWKTQRSEEYEAEGQ
LRFWNPDDLNASQSGSSPPQDWIEEKLQEVCEDLGITRDGHLNRKKLVSICEQYGLQNVDGEMLEEVFHNLDPDGTMSVEDFFYGLFKNG
KSLTPSASTPYRQLKRHLSMQSFDESGRRTTTSSAMTSTIGFRVFSCLDDGMGHASVERILDTWQEEGIENSQEILKRAAVYRMNRNHRG
LCVIVNNHSFTSLKDRQGTHKDAEILSHVFQWLGFTVHIHNNVTKVEMEMVLQKQKCNPAHADGDCFVFCILTHGRFGAVYSSDEALIPI
REIMSHFTALQCPRLAEKPKLFFIQACQGEEIQPSVSIEADALNPEQAPTSLQDSIPAEADFLLGLATVPGYVSFRHVEEGSWYIQSLCN

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>59143_59143_10_NIN-CASP10_NIN_chr14_51239019_ENST00000453196_CASP10_chr2_202072798_ENST00000286186_length(amino acids)=598AA_BP=341
MPAVRALRRDRQKVSTVGYGMDEVEQDQHEARLKELFDSFDTTGTGSLGQEELTDLCHMLSLEEVAPVLQQTLLQDNLLGRVHFDQFKEA
LILILSRTLSNEEHFQEPDCSLEAQPKYVRGGKRYGRRSLPEFQESVEEFPEVTVIEPLDEEARPSHIPAGDCSEHWKTQRSEEYEAEGQ
LRFWNPDDLNASQSGSSPPQDWIEEKLQEVCEDLGITRDGHLNRKKLVSICEQYGLQNVDGEMLEEVFHNLDPDGTMSVEDFFYGLFKNG
KSLTPSASTPYRQLKRHLSMQSFDESGRRTTTSSAMTSTIGFRVFSCLDDGMGHASVERILDTWQEEGIENSQEILKRAAVYRMNRNHRG
LCVIVNNHSFTSLKDRQGTHKDAEILSHVFQWLGFTVHIHNNVTKVEMEMVLQKQKCNPAHADGDCFVFCILTHGRFGAVYSSDEALIPI
REIMSHFTALQCPRLAEKPKLFFIQACQGEEIQPSVSIEADALNPEQAPTSLQDSIPAEADFLLGLATVPGYVSFRHVEEGSWYIQSLCN

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>59143_59143_11_NIN-CASP10_NIN_chr14_51239019_ENST00000530997_CASP10_chr2_202072798_ENST00000272879_length(amino acids)=577AA_BP=321
MDEVEQDQHEARLKELFDSFDTTGTGSLGQEELTDLCHMLSLEEVAPVLQQTLLQDNLLGRVHFDQFKEALILILSRTLSNEEHFQEPDC
SLEAQPKYVRGGKRYGRRSLPEFQESVEEFPEVTVIEPLDEEARPSHIPAGDCSEHWKTQRSEEYEAEGQLRFWNPDDLNASQSGSSPPQ
DWIEEKLQEVCEDLGITRDGHLNRKKLVSICEQYGLQNVDGEMLEEVFHNLDPDGTMSVEDFFYGLFKNGKSLTPSASTPYRQLKRHLSM
QSFDESGRRTTTSSAMTSTIGFRVFSCLDDGMGHASVERILDTWQEEGIENSQEILKRAAVYRMNRNHRGLCVIVNNHSFTSLKDRQGTH
KDAEILSHVFQWLGFTVHIHNNVTKVEMEMVLQKQKCNPAHADGDCFVFCILTHGRFGAVYSSDEALIPIREIMSHFTALQCPRLAEKPK
LFFIQACQGEEIQPSVSIEADALNPEQAPTSLQDSIPAEADFLLGLATVPGYVSFRHVEEGSWYIQSLCNHLKKLVPRMLKFLEKTMEIR

--------------------------------------------------------------

>59143_59143_12_NIN-CASP10_NIN_chr14_51239019_ENST00000530997_CASP10_chr2_202072798_ENST00000286186_length(amino acids)=578AA_BP=321
MDEVEQDQHEARLKELFDSFDTTGTGSLGQEELTDLCHMLSLEEVAPVLQQTLLQDNLLGRVHFDQFKEALILILSRTLSNEEHFQEPDC
SLEAQPKYVRGGKRYGRRSLPEFQESVEEFPEVTVIEPLDEEARPSHIPAGDCSEHWKTQRSEEYEAEGQLRFWNPDDLNASQSGSSPPQ
DWIEEKLQEVCEDLGITRDGHLNRKKLVSICEQYGLQNVDGEMLEEVFHNLDPDGTMSVEDFFYGLFKNGKSLTPSASTPYRQLKRHLSM
QSFDESGRRTTTSSAMTSTIGFRVFSCLDDGMGHASVERILDTWQEEGIENSQEILKRAAVYRMNRNHRGLCVIVNNHSFTSLKDRQGTH
KDAEILSHVFQWLGFTVHIHNNVTKVEMEMVLQKQKCNPAHADGDCFVFCILTHGRFGAVYSSDEALIPIREIMSHFTALQCPRLAEKPK
LFFIQACQGEEIQPSVSIEADALNPEQAPTSLQDSIPAEADFLLGLATVPGYVSFRHVEEGSWYIQSLCNHLKKLVPRHEDILSILTAVN

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr14:51239019/chr2:202072798)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
NIN

Q9Y2I6

CASP10

Q92851

FUNCTION: Involved in the microtubule organization in interphase cells. Overexpression induces the fragmentation of the Golgi, and causes lysosomes to disperse toward the cell periphery; it also interferes with mitotic spindle assembly. May play a role in ovarian carcinogenesis. {ECO:0000269|PubMed:12852856, ECO:0000269|PubMed:16254247, ECO:0000269|PubMed:18538832}.FUNCTION: Involved in the activation cascade of caspases responsible for apoptosis execution. Recruited to both Fas- and TNFR-1 receptors in a FADD dependent manner. May participate in the granzyme B apoptotic pathways. Cleaves and activates caspase-3, -4, -6, -7, -8, and -9. Hydrolyzes the small- molecule substrates, Tyr-Val-Ala-Asp-|-AMC and Asp-Glu-Val-Asp-|-AMC. {ECO:0000269|PubMed:11717445}.; FUNCTION: Isoform 7 can enhance NF-kappaB activity but promotes only slight apoptosis. {ECO:0000269|PubMed:17822854}.; FUNCTION: Isoform C is proteolytically inactive. {ECO:0000269|PubMed:11717445}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneNINchr14:51239019chr2:202072798ENST00000245441-931182_217327.02134.0DomainEF-hand 3
HgeneNINchr14:51239019chr2:202072798ENST00000245441-931219_252327.02134.0DomainEF-hand 4
HgeneNINchr14:51239019chr2:202072798ENST00000245441-93142_77327.02134.0DomainEF-hand 2
HgeneNINchr14:51239019chr2:202072798ENST00000245441-9318_43327.02134.0DomainEF-hand 1
HgeneNINchr14:51239019chr2:202072798ENST00000382041-930182_217327.02091.0DomainEF-hand 3
HgeneNINchr14:51239019chr2:202072798ENST00000382041-930219_252327.02091.0DomainEF-hand 4
HgeneNINchr14:51239019chr2:202072798ENST00000382041-93042_77327.02091.0DomainEF-hand 2
HgeneNINchr14:51239019chr2:202072798ENST00000382041-9308_43327.02091.0DomainEF-hand 1
HgeneNINchr14:51239019chr2:202072798ENST00000382043-828182_217327.01378.0DomainEF-hand 3
HgeneNINchr14:51239019chr2:202072798ENST00000382043-828219_252327.01378.0DomainEF-hand 4
HgeneNINchr14:51239019chr2:202072798ENST00000382043-82842_77327.01378.0DomainEF-hand 2
HgeneNINchr14:51239019chr2:202072798ENST00000382043-8288_43327.01378.0DomainEF-hand 1
HgeneNINchr14:51239019chr2:202072798ENST00000530997-729182_217327.02134.0DomainEF-hand 3
HgeneNINchr14:51239019chr2:202072798ENST00000530997-729219_252327.02134.0DomainEF-hand 4
HgeneNINchr14:51239019chr2:202072798ENST00000530997-72942_77327.02134.0DomainEF-hand 2
HgeneNINchr14:51239019chr2:202072798ENST00000530997-7298_43327.02134.0DomainEF-hand 1
HgeneNINchr14:51239019chr2:202072798ENST00000245441-931245_252327.02134.0Nucleotide bindingGTP
HgeneNINchr14:51239019chr2:202072798ENST00000245441-931300_304327.02134.0Nucleotide bindingGTP
HgeneNINchr14:51239019chr2:202072798ENST00000382041-930245_252327.02091.0Nucleotide bindingGTP
HgeneNINchr14:51239019chr2:202072798ENST00000382041-930300_304327.02091.0Nucleotide bindingGTP
HgeneNINchr14:51239019chr2:202072798ENST00000382043-828245_252327.01378.0Nucleotide bindingGTP
HgeneNINchr14:51239019chr2:202072798ENST00000382043-828300_304327.01378.0Nucleotide bindingGTP
HgeneNINchr14:51239019chr2:202072798ENST00000530997-729245_252327.02134.0Nucleotide bindingGTP
HgeneNINchr14:51239019chr2:202072798ENST00000530997-729300_304327.02134.0Nucleotide bindingGTP
TgeneCASP10chr14:51239019chr2:202072798ENST0000031372808114_1870456.0DomainDED 2
TgeneCASP10chr14:51239019chr2:202072798ENST000003137280819_970456.0DomainDED 1
TgeneCASP10chr14:51239019chr2:202072798ENST0000037465006114_1870248.0DomainDED 2
TgeneCASP10chr14:51239019chr2:202072798ENST000003746500619_970248.0DomainDED 1

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneNINchr14:51239019chr2:202072798ENST00000245441-9311068_1099327.02134.0Coiled coilOntology_term=ECO:0000255
HgeneNINchr14:51239019chr2:202072798ENST00000245441-9311181_1341327.02134.0Coiled coilOntology_term=ECO:0000255
HgeneNINchr14:51239019chr2:202072798ENST00000245441-9311441_1816327.02134.0Coiled coilOntology_term=ECO:0000255
HgeneNINchr14:51239019chr2:202072798ENST00000245441-9311854_1885327.02134.0Coiled coilOntology_term=ECO:0000255
HgeneNINchr14:51239019chr2:202072798ENST00000245441-9311922_2067327.02134.0Coiled coilOntology_term=ECO:0000255
HgeneNINchr14:51239019chr2:202072798ENST00000245441-931357_570327.02134.0Coiled coilOntology_term=ECO:0000255
HgeneNINchr14:51239019chr2:202072798ENST00000245441-931625_1027327.02134.0Coiled coilOntology_term=ECO:0000255
HgeneNINchr14:51239019chr2:202072798ENST00000382041-9301068_1099327.02091.0Coiled coilOntology_term=ECO:0000255
HgeneNINchr14:51239019chr2:202072798ENST00000382041-9301181_1341327.02091.0Coiled coilOntology_term=ECO:0000255
HgeneNINchr14:51239019chr2:202072798ENST00000382041-9301441_1816327.02091.0Coiled coilOntology_term=ECO:0000255
HgeneNINchr14:51239019chr2:202072798ENST00000382041-9301854_1885327.02091.0Coiled coilOntology_term=ECO:0000255
HgeneNINchr14:51239019chr2:202072798ENST00000382041-9301922_2067327.02091.0Coiled coilOntology_term=ECO:0000255
HgeneNINchr14:51239019chr2:202072798ENST00000382041-930357_570327.02091.0Coiled coilOntology_term=ECO:0000255
HgeneNINchr14:51239019chr2:202072798ENST00000382041-930625_1027327.02091.0Coiled coilOntology_term=ECO:0000255
HgeneNINchr14:51239019chr2:202072798ENST00000382043-8281068_1099327.01378.0Coiled coilOntology_term=ECO:0000255
HgeneNINchr14:51239019chr2:202072798ENST00000382043-8281181_1341327.01378.0Coiled coilOntology_term=ECO:0000255
HgeneNINchr14:51239019chr2:202072798ENST00000382043-8281441_1816327.01378.0Coiled coilOntology_term=ECO:0000255
HgeneNINchr14:51239019chr2:202072798ENST00000382043-8281854_1885327.01378.0Coiled coilOntology_term=ECO:0000255
HgeneNINchr14:51239019chr2:202072798ENST00000382043-8281922_2067327.01378.0Coiled coilOntology_term=ECO:0000255
HgeneNINchr14:51239019chr2:202072798ENST00000382043-828357_570327.01378.0Coiled coilOntology_term=ECO:0000255
HgeneNINchr14:51239019chr2:202072798ENST00000382043-828625_1027327.01378.0Coiled coilOntology_term=ECO:0000255
HgeneNINchr14:51239019chr2:202072798ENST00000530997-7291068_1099327.02134.0Coiled coilOntology_term=ECO:0000255
HgeneNINchr14:51239019chr2:202072798ENST00000530997-7291181_1341327.02134.0Coiled coilOntology_term=ECO:0000255
HgeneNINchr14:51239019chr2:202072798ENST00000530997-7291441_1816327.02134.0Coiled coilOntology_term=ECO:0000255
HgeneNINchr14:51239019chr2:202072798ENST00000530997-7291854_1885327.02134.0Coiled coilOntology_term=ECO:0000255
HgeneNINchr14:51239019chr2:202072798ENST00000530997-7291922_2067327.02134.0Coiled coilOntology_term=ECO:0000255
HgeneNINchr14:51239019chr2:202072798ENST00000530997-729357_570327.02134.0Coiled coilOntology_term=ECO:0000255
HgeneNINchr14:51239019chr2:202072798ENST00000530997-729625_1027327.02134.0Coiled coilOntology_term=ECO:0000255
HgeneNINchr14:51239019chr2:202072798ENST00000245441-931317_352327.02134.0DomainEF-hand 5
HgeneNINchr14:51239019chr2:202072798ENST00000382041-930317_352327.02091.0DomainEF-hand 5
HgeneNINchr14:51239019chr2:202072798ENST00000382043-828317_352327.01378.0DomainEF-hand 5
HgeneNINchr14:51239019chr2:202072798ENST00000530997-729317_352327.02134.0DomainEF-hand 5
HgeneNINchr14:51239019chr2:202072798ENST00000245441-931420_423327.02134.0Nucleotide bindingGTP
HgeneNINchr14:51239019chr2:202072798ENST00000382041-930420_423327.02091.0Nucleotide bindingGTP
HgeneNINchr14:51239019chr2:202072798ENST00000382043-828420_423327.01378.0Nucleotide bindingGTP
HgeneNINchr14:51239019chr2:202072798ENST00000530997-729420_423327.02134.0Nucleotide bindingGTP
TgeneCASP10chr14:51239019chr2:202072798ENST00000272879610114_187271.0522.0DomainDED 2
TgeneCASP10chr14:51239019chr2:202072798ENST0000027287961019_97271.0522.0DomainDED 1
TgeneCASP10chr14:51239019chr2:202072798ENST00000286186610114_187271.0523.0DomainDED 2
TgeneCASP10chr14:51239019chr2:202072798ENST0000028618661019_97271.0523.0DomainDED 1
TgeneCASP10chr14:51239019chr2:202072798ENST0000034681748114_187228.0480.0DomainDED 2
TgeneCASP10chr14:51239019chr2:202072798ENST000003468174819_97228.0480.0DomainDED 1
TgeneCASP10chr14:51239019chr2:202072798ENST0000036013259114_187240.333333333333341541.0DomainDED 2
TgeneCASP10chr14:51239019chr2:202072798ENST000003601325919_97240.333333333333341541.0DomainDED 1
TgeneCASP10chr14:51239019chr2:202072798ENST0000044848048114_187228.0479.0DomainDED 2
TgeneCASP10chr14:51239019chr2:202072798ENST000004484804819_97228.0479.0DomainDED 1


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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors
NINNIN, PRKACA, AURKA, GSK3B, AMOT, ELAVL1, LATS2, CEP170, CCDC68, TMOD1, CASQ2, C17orf59, CEP63, MED4, HERC2, OFD1, CEP128, CNTRL, ACTR1A, ANLN, AP3D1, CEP131, BAIAP2, CAMK2D, CC2D1A, CCDC138, CCNB1, CCNB2, CENPE, CEP164, CEP350, CKAP2, CLASP1, CLASP2, CSPP1, DBT, DCTN1, DCTN2, DHX35, DIAPH3, DYNC1H1, DYNC1I2, DYNC1LI1, DYNC1LI2, ECH1, EIF4ENIF1, ERC1, FAM83B, FGFR1OP, GPATCH1, HAUS1, HAUS3, HAUS4, HAUS5, HAUS6, HAUS7, HAUS8, HECTD1, HMMR, IQCB1, KIAA1671, KIF14, LUZP1, MAP7D3, MGA, NCKAP5L, NEDD1, NME7, PALLD, PCM1, PLK1, RASSF8, RLTPR, SAMD4B, SDCCAG3, SPC24, SVIL, TJP1, TNRC6B, TP53, TP53BP2, TTC28, TTF2, TTK, TXLNA, UNC45A, UPF1, WDR83, ACTR2, AHCY, ARPC3, CEP192, CSNK1A1, HMGN3, ISOC1, PIBF1, PMPCB, RAB2A, SSX2IP, TCHP, YWHAH, POC5, KIAA1244, NHP2L1, BAX, MYH13, DOT1L, Cep131, Wdr61, Fus, CDC14A, SYCE3, TCP10L, ZNF331, COG5, EGLN3, RBM10, GTSE1, YWHAE, KLC1, KIAA1429, DYNC1I1, APRT, DSG2, EIF6, ERLIN1, FLOT2, GANAB, GCAT, GNAI3, GSK3A, HUS1, LIPA, MCU, MEN1, MIA3, MRPL41, MSTO1, PCID2, PKP4, PRIM1, PUS1, RAB3B, RFC5, RPL35, SENP1, SLC25A15, STXBP3, TIMM44, TMEM165, TUBA1C, ATP6V1H, ANXA2, IQGAP1, ESYT2, ATP1A1, NUP93, NUP205, SLC25A4, CEP55, WDR3, MYO1D, DNAJB6, LMNB1, PLOD1, AGRN, RPL7, KRT5, NOMO2, GFPT1, ARHGEF2, PRDX4, ACOT9, MCM3, TAF2, LONP1, PFKM, DHX40, FLOT1, MTPAP, PPM1F, RBM14, TUBB6, ARCN1, DNAJA3, LTBP4, TUBB4A, AASS, XIAP, TSFM, ETFA, GTPBP1, GCLM, BICD1, ACTR10, C1orf198, C2CD3, C5orf42, CCDC14, CCDC22, CCDC57, CCDC66, CCDC77, CCDC85C, CCHCR1, CENPJ, CEP135, CEP152, CEP162, CEP170B, CEP250, CEP290, CEP295, CEP85L, CEP95, CGNL1, CIAPIN1, DCTN3, DCTN4, EIF4E2, FAM184A, FAM83G, FOPNL, GRN, ICK, IFFO2, KIF7, KIZ, LATS1, LCA5, LRRCC1, C17orf104, MZT2B, NDE1, ODF2, PDZRN3, PLEKHG1, PPP1R13B, PPP2R3A, PROSER3, PXN, RNF135, RPGRIP1L, SASS6, SCLT1, SPATA2, STIL, TBC1D5, TBKBP1, TEX9, TTC30A, TTLL5, TUBGCP2, TXLNG, WRAP73, YTHDF2, ALMS1, PCNT, SIPA1L3, CYLD, ANKRD26, TBC1D31, FAM83H, USP54, SPAG5, IFT81, LIMD1, CAMSAP1, BACH2, SIPA1L2, CKAP5, INA, GIGYF2, TANC1, CEP97, CTTN, CAMSAP3, HAUS2, ARHGAP21, CAPZB, CAMSAP2, VCPIP1, TTC26, XRN1, EIF4G2, SMG7, RINT1, APC, IFT74, TNRC6A, MIB1, ANKHD1-EIF4EBP3, TBK1, SIPA1L1, NDC80, BRCA2, IFT46, PRKACB, EXOC4, KRT8, L3MBTL2, TRIO, KNSTRN, DPYSL2, PSMC2, KRT19, BICD2, KIAA1217, ZNF598, CAPZA1, nsp13, C14orf166, AUNIP, HIST1H1A, CIT, KIF23, TRIM33, nsp13ab, ORF6, DNAJB5, KDM1A, KRT18, MLLT4, SEPT10, SYNE3, VPS33A, VPS33B, CEP170P1, C15orf59, PIP, ARSE, CCDC96, NUP62, KXD1, WHAMMP3, SNRPC, MBD3L2, PTP4A3, KRT38, SGCA, SERINC2, RNF185, MRPL38, SKA3, APLNR, CCDC51, SNW1, PRPF6, UTP14A,


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
NINall structure
CASP10


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to NIN-CASP10


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to NIN-CASP10


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneNINC3553870SECKEL SYNDROME 72GENOMICS_ENGLAND;ORPHANET;UNIPROT