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	Fusion Gene Summary
	Fusion Gene Sample Information
	Fusion ORF Analysis
	Fusion Amino Acid Sequences
	Fusion Protein Functional Features
	Fusion Protein Structure
	pLDDT scores
	Ramachandran Plot of Fusion Protein Structure
	Fusion Protein-Protein Interaction
	Related drugs with this fusion protein
	Related disease with this fusion protein

Fusion Protein:NOMO3-TFAP4

Fusion Protein Summary

Fusion gene summary

Fusion partner gene information	Fusion gene name: NOMO3-TFAP4
	FusionPDB ID: 59606
	FusionGDB2.0 ID: 59606
		Hgene	Tgene
	Gene symbol	NOMO3	TFAP4
	Gene ID	408050	7023
	Gene name	NODAL modulator 3	transcription factor AP-4
	Synonyms	Nomo	AP-4\|bHLHc41
	Cytomap	16p13.11	16p13.3
	Type of gene	protein-coding	protein-coding
	Description	nodal modulator 3pM5 protein 3pM5 protein, middle copy	transcription factor AP-4activating enhancer-binding protein 4class C basic helix-loop-helix protein 41transcription factor AP-4 (activating enhancer binding protein 4)
	Modification date	20200314	20200322
	UniProtAcc	P69849	.
Ensembl transtripts involved in fusion gene	ENST ids	ENST00000263012, ENST00000399336, ENST00000538468, ENST00000572932,	ENST00000204517,
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)	* DoF score	4 X 4 X 4=64	4 X 4 X 4=64
	# samples	4	4
	** MAII score	log2(4/64*10)=-0.678071905112638 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(4/64*10)=-0.678071905112638 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)	PubMed: NOMO3 [Title/Abstract] AND TFAP4 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)	NOMO3(16350015)-TFAP4(4312702), # samples:3
Anticipated loss of major functional domain due to fusion event.	NOMO3-TFAP4 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. NOMO3-TFAP4 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Tgene	TFAP4	GO:0006978	DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator	18818310
Tgene	TFAP4	GO:0043065	positive regulation of apoptotic process	18818310
Tgene	TFAP4	GO:0043392	negative regulation of DNA binding	7933101\|16540471
Tgene	TFAP4	GO:0043922	negative regulation by host of viral transcription	14645924\|16540471
Tgene	TFAP4	GO:0043923	positive regulation by host of viral transcription	2833704
Tgene	TFAP4	GO:0045736	negative regulation of cyclin-dependent protein serine/threonine kinase activity	18818310
Tgene	TFAP4	GO:0045892	negative regulation of transcription, DNA-templated	9931457\|16924111\|19505873
Tgene	TFAP4	GO:0065003	protein-containing complex assembly	19505873
Tgene	TFAP4	GO:1901990	regulation of mitotic cell cycle phase transition	18818310

Fusion gene breakpoints across NOMO3 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across TFAP4 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

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Fusion Gene Sample Information

Fusion gene information from FusionGDB2.0.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	BRCA	TCGA-S3-AA0Z-01A	NOMO3	chr16	16350014	+	TFAP4	chr16	4312701	-
ChimerDB4	BRCA	TCGA-S3-AA0Z-01A	NOMO3	chr16	16350015	+	TFAP4	chr16	4312702	-
ChimerDB4	BRCA	TCGA-S3-AA0Z	NOMO3	chr16	16350015	+	TFAP4	chr16	4312702	-

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Fusion ORF Analysis

Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000399336	NOMO3	chr16	16350015	+	ENST00000204517	TFAP4	chr16	4312702	-	3189	1392	136	2319	727
ENST00000263012	NOMO3	chr16	16350015	+	ENST00000204517	TFAP4	chr16	4312702	-	3083	1286	30	2213	727
ENST00000538468	NOMO3	chr16	16350015	+	ENST00000204517	TFAP4	chr16	4312702	-	2944	1147	428	2074	548
ENST00000399336	NOMO3	chr16	16350014	+	ENST00000204517	TFAP4	chr16	4312701	-	3189	1392	136	2319	727
ENST00000263012	NOMO3	chr16	16350014	+	ENST00000204517	TFAP4	chr16	4312701	-	3083	1286	30	2213	727
ENST00000538468	NOMO3	chr16	16350014	+	ENST00000204517	TFAP4	chr16	4312701	-	2944	1147	428	2074	548

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000399336	ENST00000204517	NOMO3	chr16	16350015	+	TFAP4	chr16	4312702	-	0.001247766	0.99875224
ENST00000263012	ENST00000204517	NOMO3	chr16	16350015	+	TFAP4	chr16	4312702	-	0.001291441	0.9987086
ENST00000538468	ENST00000204517	NOMO3	chr16	16350015	+	TFAP4	chr16	4312702	-	0.002713973	0.9972861
ENST00000399336	ENST00000204517	NOMO3	chr16	16350014	+	TFAP4	chr16	4312701	-	0.001247766	0.99875224
ENST00000263012	ENST00000204517	NOMO3	chr16	16350014	+	TFAP4	chr16	4312701	-	0.001291441	0.9987086
ENST00000538468	ENST00000204517	NOMO3	chr16	16350014	+	TFAP4	chr16	4312701	-	0.002713973	0.9972861

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Fusion Amino Acid Sequences

For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>59606_59606_1_NOMO3-TFAP4_NOMO3_chr16_16350014_ENST00000263012_TFAP4_chr16_4312701_ENST00000204517_length(amino acids)=727AA_BP=419
MPAVGLAGGGRAMLVGQGAGPLGPAVVTAAVVLLLSGVGPAHGSEDIVVGCGGFVKSDVEINYSLIEIKLYTKHGTLKYQTDCAPNNGYF
MIPLYDKGDFILKIEPPLGWSFEPTTVELHVDGVSDICTKGGDINFVFTGFSVNGKVLSKGQPLGPAGVQVSLRNTGTEAKIQSTVTQPG
GKFAFFKVLPGDYEILATHPTWALKEASTTVRVTNSNANAASPLIVAGYNVSGSVRSDGEPMKGVKFLLFSSLVTKEDVLGCNVSPVPGF
QPQDESLVYLCYTVSREDGSFSFYSLPSGGYTVIPFYRGERITFDVAPSRLDFTVEHDSLKIEPVFHVMGFSVTGRVLNGPEGDGVPEAV
VTLNNQIKVKTKADGSFRLENITTGTYTIHAQKEHLYFETVTIKIAPNTPQLADIVATGLANIPLTPETQRDQERRIRREIANSNERRRM
QSINAGFQSLKTLIPHTDGEKLSKAAILQQTAEYIFSLEQEKTRLLQQNTQLKRFIQELSGSSPKRRRAEDKDEGIGSPDIWEDEKAEDL
RREMIELRQQLDKERSVRMMLEEQVRSLEAHMYPEKLKVIAQQVQLQQQQEQVRLLHQEKLEREQQQLRTQLLPPPAPTHHPTVIVPAPP
PPPSHHINVVTMGPSSVINSVSTSRQNLDTIVQAIQHIEGTQEKQELEEEQRRAVIVKPVRSCPEAPTSDTASDSEASDSDAMDQSREEP

--------------------------------------------------------------

>59606_59606_2_NOMO3-TFAP4_NOMO3_chr16_16350014_ENST00000399336_TFAP4_chr16_4312701_ENST00000204517_length(amino acids)=727AA_BP=419
MPAVGLAGGGRAMLVGQGAGPLGPAVVTAAVVLLLSGVGPAHGSEDIVVGCGGFVKSDVEINYSLIEIKLYTKHGTLKYQTDCAPNNGYF
MIPLYDKGDFILKIEPPLGWSFEPTTVELHVDGVSDICTKGGDINFVFTGFSVNGKVLSKGQPLGPAGVQVSLRNTGTEAKIQSTVTQPG
GKFAFFKVLPGDYEILATHPTWALKEASTTVRVTNSNANAASPLIVAGYNVSGSVRSDGEPMKGVKFLLFSSLVTKEDVLGCNVSPVPGF
QPQDESLVYLCYTVSREDGSFSFYSLPSGGYTVIPFYRGERITFDVAPSRLDFTVEHDSLKIEPVFHVMGFSVTGRVLNGPEGDGVPEAV
VTLNNQIKVKTKADGSFRLENITTGTYTIHAQKEHLYFETVTIKIAPNTPQLADIVATGLANIPLTPETQRDQERRIRREIANSNERRRM
QSINAGFQSLKTLIPHTDGEKLSKAAILQQTAEYIFSLEQEKTRLLQQNTQLKRFIQELSGSSPKRRRAEDKDEGIGSPDIWEDEKAEDL
RREMIELRQQLDKERSVRMMLEEQVRSLEAHMYPEKLKVIAQQVQLQQQQEQVRLLHQEKLEREQQQLRTQLLPPPAPTHHPTVIVPAPP
PPPSHHINVVTMGPSSVINSVSTSRQNLDTIVQAIQHIEGTQEKQELEEEQRRAVIVKPVRSCPEAPTSDTASDSEASDSDAMDQSREEP

--------------------------------------------------------------

>59606_59606_3_NOMO3-TFAP4_NOMO3_chr16_16350014_ENST00000538468_TFAP4_chr16_4312701_ENST00000204517_length(amino acids)=548AA_BP=240
MARFAFFKVLPGDYEILATHPTWALKEASTTVRVTNSNANAASPLIVAGYNVSGSVRSDGEPMKGVKFLLFSSLVTKEDVLGCNVSPVPG
FQPQDESLVYLCYTVSREDGSFSFYSLPSGGYTVIPFYRGERITFDVAPSRLDFTVEHDSLKIEPVFHVMGFSVTGRVLNGPEGDGVPEA
VVTLNNQIKVKTKADGSFRLENITTGTYTIHAQKEHLYFETVTIKIAPNTPQLADIVATGLANIPLTPETQRDQERRIRREIANSNERRR
MQSINAGFQSLKTLIPHTDGEKLSKAAILQQTAEYIFSLEQEKTRLLQQNTQLKRFIQELSGSSPKRRRAEDKDEGIGSPDIWEDEKAED
LRREMIELRQQLDKERSVRMMLEEQVRSLEAHMYPEKLKVIAQQVQLQQQQEQVRLLHQEKLEREQQQLRTQLLPPPAPTHHPTVIVPAP
PPPPSHHINVVTMGPSSVINSVSTSRQNLDTIVQAIQHIEGTQEKQELEEEQRRAVIVKPVRSCPEAPTSDTASDSEASDSDAMDQSREE

--------------------------------------------------------------

>59606_59606_4_NOMO3-TFAP4_NOMO3_chr16_16350015_ENST00000263012_TFAP4_chr16_4312702_ENST00000204517_length(amino acids)=727AA_BP=419
MPAVGLAGGGRAMLVGQGAGPLGPAVVTAAVVLLLSGVGPAHGSEDIVVGCGGFVKSDVEINYSLIEIKLYTKHGTLKYQTDCAPNNGYF
MIPLYDKGDFILKIEPPLGWSFEPTTVELHVDGVSDICTKGGDINFVFTGFSVNGKVLSKGQPLGPAGVQVSLRNTGTEAKIQSTVTQPG
GKFAFFKVLPGDYEILATHPTWALKEASTTVRVTNSNANAASPLIVAGYNVSGSVRSDGEPMKGVKFLLFSSLVTKEDVLGCNVSPVPGF
QPQDESLVYLCYTVSREDGSFSFYSLPSGGYTVIPFYRGERITFDVAPSRLDFTVEHDSLKIEPVFHVMGFSVTGRVLNGPEGDGVPEAV
VTLNNQIKVKTKADGSFRLENITTGTYTIHAQKEHLYFETVTIKIAPNTPQLADIVATGLANIPLTPETQRDQERRIRREIANSNERRRM
QSINAGFQSLKTLIPHTDGEKLSKAAILQQTAEYIFSLEQEKTRLLQQNTQLKRFIQELSGSSPKRRRAEDKDEGIGSPDIWEDEKAEDL
RREMIELRQQLDKERSVRMMLEEQVRSLEAHMYPEKLKVIAQQVQLQQQQEQVRLLHQEKLEREQQQLRTQLLPPPAPTHHPTVIVPAPP
PPPSHHINVVTMGPSSVINSVSTSRQNLDTIVQAIQHIEGTQEKQELEEEQRRAVIVKPVRSCPEAPTSDTASDSEASDSDAMDQSREEP

--------------------------------------------------------------

>59606_59606_5_NOMO3-TFAP4_NOMO3_chr16_16350015_ENST00000399336_TFAP4_chr16_4312702_ENST00000204517_length(amino acids)=727AA_BP=419
MPAVGLAGGGRAMLVGQGAGPLGPAVVTAAVVLLLSGVGPAHGSEDIVVGCGGFVKSDVEINYSLIEIKLYTKHGTLKYQTDCAPNNGYF
MIPLYDKGDFILKIEPPLGWSFEPTTVELHVDGVSDICTKGGDINFVFTGFSVNGKVLSKGQPLGPAGVQVSLRNTGTEAKIQSTVTQPG
GKFAFFKVLPGDYEILATHPTWALKEASTTVRVTNSNANAASPLIVAGYNVSGSVRSDGEPMKGVKFLLFSSLVTKEDVLGCNVSPVPGF
QPQDESLVYLCYTVSREDGSFSFYSLPSGGYTVIPFYRGERITFDVAPSRLDFTVEHDSLKIEPVFHVMGFSVTGRVLNGPEGDGVPEAV
VTLNNQIKVKTKADGSFRLENITTGTYTIHAQKEHLYFETVTIKIAPNTPQLADIVATGLANIPLTPETQRDQERRIRREIANSNERRRM
QSINAGFQSLKTLIPHTDGEKLSKAAILQQTAEYIFSLEQEKTRLLQQNTQLKRFIQELSGSSPKRRRAEDKDEGIGSPDIWEDEKAEDL
RREMIELRQQLDKERSVRMMLEEQVRSLEAHMYPEKLKVIAQQVQLQQQQEQVRLLHQEKLEREQQQLRTQLLPPPAPTHHPTVIVPAPP
PPPSHHINVVTMGPSSVINSVSTSRQNLDTIVQAIQHIEGTQEKQELEEEQRRAVIVKPVRSCPEAPTSDTASDSEASDSDAMDQSREEP

--------------------------------------------------------------

>59606_59606_6_NOMO3-TFAP4_NOMO3_chr16_16350015_ENST00000538468_TFAP4_chr16_4312702_ENST00000204517_length(amino acids)=548AA_BP=240
MARFAFFKVLPGDYEILATHPTWALKEASTTVRVTNSNANAASPLIVAGYNVSGSVRSDGEPMKGVKFLLFSSLVTKEDVLGCNVSPVPG
FQPQDESLVYLCYTVSREDGSFSFYSLPSGGYTVIPFYRGERITFDVAPSRLDFTVEHDSLKIEPVFHVMGFSVTGRVLNGPEGDGVPEA
VVTLNNQIKVKTKADGSFRLENITTGTYTIHAQKEHLYFETVTIKIAPNTPQLADIVATGLANIPLTPETQRDQERRIRREIANSNERRR
MQSINAGFQSLKTLIPHTDGEKLSKAAILQQTAEYIFSLEQEKTRLLQQNTQLKRFIQELSGSSPKRRRAEDKDEGIGSPDIWEDEKAED
LRREMIELRQQLDKERSVRMMLEEQVRSLEAHMYPEKLKVIAQQVQLQQQQEQVRLLHQEKLEREQQQLRTQLLPPPAPTHHPTVIVPAP
PPPPSHHINVVTMGPSSVINSVSTSRQNLDTIVQAIQHIEGTQEKQELEEEQRRAVIVKPVRSCPEAPTSDTASDSEASDSDAMDQSREE

--------------------------------------------------------------

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Fusion Protein Functional Features

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr16:16350015/chr16:4312702)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
NOMO3 P69849	.
FUNCTION: May antagonize Nodal signaling. {ECO:0000250}.	FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
* Minus value of BPloci means that the break pointn is located before the CDS.

- Retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

TFAP4

chr16:16350014

chr16:4312701

ENST00000204517

193_222

29.666666666666668

339.0

Compositional bias

Note=Gln-rich

Tgene

TFAP4

chr16:16350014

chr16:4312701

ENST00000204517

225_244

29.666666666666668

339.0

Compositional bias

Note=Pro-rich

Tgene

TFAP4

chr16:16350015

chr16:4312702

ENST00000204517

193_222

29.666666666666668

339.0

Compositional bias

Note=Gln-rich

Tgene

TFAP4

chr16:16350015

chr16:4312702

ENST00000204517

225_244

29.666666666666668

339.0

Compositional bias

Note=Pro-rich

Tgene

TFAP4

chr16:16350014

chr16:4312701

ENST00000204517

48_99

29.666666666666668

339.0

Domain

bHLH

Tgene

TFAP4

chr16:16350015

chr16:4312702

ENST00000204517

48_99

29.666666666666668

339.0

Domain

bHLH

Tgene

TFAP4

chr16:16350014

chr16:4312701

ENST00000204517

100_120

29.666666666666668

339.0

Region

Note=Leucine-zipper 1

Tgene

TFAP4

chr16:16350014

chr16:4312701

ENST00000204517

151_179

29.666666666666668

339.0

Region

Note=Leucine-zipper 2

Tgene

TFAP4

chr16:16350015

chr16:4312702

ENST00000204517

100_120

29.666666666666668

339.0

Region

Note=Leucine-zipper 1

Tgene

TFAP4

chr16:16350015

chr16:4312702

ENST00000204517

151_179

29.666666666666668

339.0

Region

Note=Leucine-zipper 2

- Not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

NOMO3

chr16:16350014

chr16:4312701

ENST00000399336

1177_1222

406.6666666666667

1223.0

Topological domain

Cytoplasmic

Hgene

NOMO3

chr16:16350014

chr16:4312701

ENST00000399336

32_1155

406.6666666666667

1223.0

Topological domain

Extracellular

Hgene

NOMO3

chr16:16350015

chr16:4312702

ENST00000399336

1177_1222

406.6666666666667

1223.0

Topological domain

Cytoplasmic

Hgene

NOMO3

chr16:16350015

chr16:4312702

ENST00000399336

32_1155

406.6666666666667

1223.0

Topological domain

Extracellular

Hgene

NOMO3

chr16:16350014

chr16:4312701

ENST00000399336

1156_1176

406.6666666666667

1223.0

Transmembrane

Helical

Hgene

NOMO3

chr16:16350015

chr16:4312702

ENST00000399336

1156_1176

406.6666666666667

1223.0

Transmembrane

Helical

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Fusion Protein Structures

PDB and CIF files of the predicted fusion proteins
* Here we show the 3D structure of the fusion proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format.

Fusion protein PDB link (fusion AA seq ID in FusionPDB)

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

AA seq

Len(AA seq)

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pLDDT score distribution

pLDDT score distribution of the predicted wild-type structures of two partner proteins from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.

NOMO3_pLDDT.png

TFAP4_pLDDT.png

pLDDT score distribution of the predicted fusion protein structures from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.

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Ramachandran Plot of Fusion Protein Structure

Ramachandran plot of the torsional angles - phi (φ)and psi (ψ) - of the residues (amino acids) contained in this fusion protein peptide.

Fusion AA seq ID in FusionPDB and their Ramachandran plots

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Fusion Protein-Protein Interaction

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)

Gene

PPI interactors

Protein-protein interactors based on sequence similarity (STRING)

Gene	STRING network
NOMO3
TFAP4

- Retained interactions in fusion protein (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost interactions due to fusion (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs to NOMO3-TFAP4

Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Drug

Source

PMID

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Related Diseases to NOMO3-TFAP4

Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Disease

Source

PMID

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source