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Center for Computational Systems Medicine level1
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:NOTCH1-NUP214

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: NOTCH1-NUP214
FusionPDB ID: 59714
FusionGDB2.0 ID: 59714
HgeneTgene
Gene symbol

NOTCH1

NUP214

Gene ID

4851

8021

Gene namenotch receptor 1nucleoporin 214
SynonymsAOS5|AOVD1|TAN1|hN1CAIN|CAN|IIAE9
Cytomap

9q34.3

9q34.13

Type of geneprotein-codingprotein-coding
Descriptionneurogenic locus notch homolog protein 1Notch homolog 1, translocation-associatednotch 1translocation-associated notch protein TAN-1nuclear pore complex protein Nup214CAN protein, putative oncogenenucleoporin 214kDa
Modification date2020032920200322
UniProtAcc

P46531

P35658

Ensembl transtripts involved in fusion geneENST idsENST00000277541, ENST00000491649, 
ENST00000465486, ENST00000483497, 
ENST00000359428, ENST00000411637, 
ENST00000451030, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score22 X 18 X 15=594019 X 26 X 11=5434
# samples 2429
** MAII scorelog2(24/5940*10)=-4.62935662007961
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(29/5434*10)=-4.22788976020704
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: NOTCH1 [Title/Abstract] AND NUP214 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)NOTCH1(139438476)-NUP214(134062675), # samples:1
Anticipated loss of major functional domain due to fusion event.NOTCH1-NUP214 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
NOTCH1-NUP214 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
NOTCH1-NUP214 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
NOTCH1-NUP214 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneNOTCH1

GO:0007050

cell cycle arrest

11306509

HgeneNOTCH1

GO:0007219

Notch signaling pathway

11306509

HgeneNOTCH1

GO:0008284

positive regulation of cell proliferation

17849174

HgeneNOTCH1

GO:0008285

negative regulation of cell proliferation

11306509|20616313

HgeneNOTCH1

GO:0010629

negative regulation of gene expression

11306509

HgeneNOTCH1

GO:0010812

negative regulation of cell-substrate adhesion

16501043

HgeneNOTCH1

GO:0035924

cellular response to vascular endothelial growth factor stimulus

20616313

HgeneNOTCH1

GO:0045944

positive regulation of transcription by RNA polymerase II

20616313

HgeneNOTCH1

GO:0045967

negative regulation of growth rate

11306509

HgeneNOTCH1

GO:0046579

positive regulation of Ras protein signal transduction

11306509

HgeneNOTCH1

GO:0070374

positive regulation of ERK1 and ERK2 cascade

11306509

HgeneNOTCH1

GO:0071372

cellular response to follicle-stimulating hormone stimulus

20613903

HgeneNOTCH1

GO:0090051

negative regulation of cell migration involved in sprouting angiogenesis

20616313

HgeneNOTCH1

GO:2001027

negative regulation of endothelial cell chemotaxis

20616313


check buttonFusion gene breakpoints across NOTCH1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across NUP214 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS5.0N/AXX000003NOTCH1chr9

139438476

-NUP214chr9

134062675

+


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000277541NOTCH1chr9139438476-ENST00000359428NUP214chr9134062675+4253216763069997
ENST00000277541NOTCH1chr9139438476-ENST00000411637NUP214chr9134062675+4246216763069997
ENST00000277541NOTCH1chr9139438476-ENST00000451030NUP214chr9134062675+3284216763069997

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000277541ENST00000359428NOTCH1chr9139438476-NUP214chr9134062675+0.007507610.9924924
ENST00000277541ENST00000411637NOTCH1chr9139438476-NUP214chr9134062675+0.0074264390.9925735
ENST00000277541ENST00000451030NOTCH1chr9139438476-NUP214chr9134062675+0.0102988820.98970115

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>59714_59714_1_NOTCH1-NUP214_NOTCH1_chr9_139438476_ENST00000277541_NUP214_chr9_134062675_ENST00000359428_length(amino acids)=997AA_BP=47
MPPLLAPLLCLALLPALAARGPRCSQPGETCLNGGKCEAANGTEACVSSVPYSTAKTPHPVLTPVAANQAKQGSLINSLKPSGPTPASGQ
LSSGDKASGTAKIETAVTSTPSASGQFSKPFSFSPSGTGFNFGIITPTPSSNFTAAQGATPSTKESSQPDAFSSGGGSKPSYEAIPESSP
PSGITSASNTTPGEPAASSSRPVAPSGTALSTTSSKLETPPSKLGELLFPSSLAGETLGSFSGLRVGQADDSTKPTNKASSTSLTSTQPT
KTSGVPSGFNFTAPPVLGKHTEPPVTSSATTTSVAPPAATSTSSTAVFGSLPVTSAGSSGVISFGGTSLSAGKTSFSFGSQQTNSTVPPS
APPPTTAATPLPTSFPTLSFGSLLSSATTPSLPMSAGRSTEEATSSALPEKPGDSEVSASAASLLEEQQSAQLPQAPPQTSDSVKKEPVL
AQPAVSNSGTAASSTSLVALSAEATPATTGVPDARTEAVPPASSFSVPGQTAVTAAAISSAGPVAVETSSTPIASSTTSIVAPGPSAEAA
AFGTVTSGSSVFAQPPAASSSSAFNQLTNNTATAPSATPVFGQVAASTAPSLFGQQTGSTASTAAATPQVSSSGFSSPAFGTTAPGVFGQ
TTFGQASVFGQSASSAASVFSFSQPGFSSVPAFGQPASSTPTSTSGSVFGAASSTSSSSSFSFGQSSPNTGGGLFGQSNAPAFGQSPGFG
QGGSVFGGTSAATTTAATSGFSFCQASGFGSSNTGSVFGQAASTGGIVFGQQSSSSSGSVFGSGNTGRGGGFFSGLGGKPSQDAANKNPF
SSASGGFGSTATSNTSNLFGNSGAKTFGGFASSSFGEQKPTGTFSSGGGSVASQGFGFSSPNKTGGFGAAPVFGSPPTFGGSPGFGGVPA
FGSAPAFTSPLGSTGGKVFGEGTAAASAGGFGFGSSSNTTSFGTLASQNAPTFGSLSQQTSGFGTQSSGFSGFGSGTGGFSFGSNNSSVQ

--------------------------------------------------------------

>59714_59714_2_NOTCH1-NUP214_NOTCH1_chr9_139438476_ENST00000277541_NUP214_chr9_134062675_ENST00000411637_length(amino acids)=997AA_BP=47
MPPLLAPLLCLALLPALAARGPRCSQPGETCLNGGKCEAANGTEACVSSVPYSTAKTPHPVLTPVAANQAKQGSLINSLKPSGPTPASGQ
LSSGDKASGTAKIETAVTSTPSASGQFSKPFSFSPSGTGFNFGIITPTPSSNFTAAQGATPSTKESSQPDAFSSGGGSKPSYEAIPESSP
PSGITSASNTTPGEPAASSSRPVAPSGTALSTTSSKLETPPSKLGELLFPSSLAGETLGSFSGLRVGQADDSTKPTNKASSTSLTSTQPT
KTSGVPSGFNFTAPPVLGKHTEPPVTSSATTTSVAPPAATSTSSTAVFGSLPVTSAGSSGVISFGGTSLSAGKTSFSFGSQQTNSTVPPS
APPPTTAATPLPTSFPTLSFGSLLSSATTPSLPMSAGRSTEEATSSALPEKPGDSEVSASAASLLEEQQSAQLPQAPPQTSDSVKKEPVL
AQPAVSNSGTAASSTSLVALSAEATPATTGVPDARTEAVPPASSFSVPGQTAVTAAAISSAGPVAVETSSTPIASSTTSIVAPGPSAEAA
AFGTVTSGSSVFAQPPAASSSSAFNQLTNNTATAPSATPVFGQVAASTAPSLFGQQTGSTASTAAATPQVSSSGFSSPAFGTTAPGVFGQ
TTFGQASVFGQSASSAASVFSFSQPGFSSVPAFGQPASSTPTSTSGSVFGAASSTSSSSSFSFGQSSPNTGGGLFGQSNAPAFGQSPGFG
QGGSVFGGTSAATTTAATSGFSFCQASGFGSSNTGSVFGQAASTGGIVFGQQSSSSSGSVFGSGNTGRGGGFFSGLGGKPSQDAANKNPF
SSASGGFGSTATSNTSNLFGNSGAKTFGGFASSSFGEQKPTGTFSSGGGSVASQGFGFSSPNKTGGFGAAPVFGSPPTFGGSPGFGGVPA
FGSAPAFTSPLGSTGGKVFGEGTAAASAGGFGFGSSSNTTSFGTLASQNAPTFGSLSQQTSGFGTQSSGFSGFGSGTGGFSFGSNNSSVQ

--------------------------------------------------------------

>59714_59714_3_NOTCH1-NUP214_NOTCH1_chr9_139438476_ENST00000277541_NUP214_chr9_134062675_ENST00000451030_length(amino acids)=997AA_BP=47
MPPLLAPLLCLALLPALAARGPRCSQPGETCLNGGKCEAANGTEACVSSVPYSTAKTPHPVLTPVAANQAKQGSLINSLKPSGPTPASGQ
LSSGDKASGTAKIETAVTSTPSASGQFSKPFSFSPSGTGFNFGIITPTPSSNFTAAQGATPSTKESSQPDAFSSGGGSKPSYEAIPESSP
PSGITSASNTTPGEPAASSSRPVAPSGTALSTTSSKLETPPSKLGELLFPSSLAGETLGSFSGLRVGQADDSTKPTNKASSTSLTSTQPT
KTSGVPSGFNFTAPPVLGKHTEPPVTSSATTTSVAPPAATSTSSTAVFGSLPVTSAGSSGVISFGGTSLSAGKTSFSFGSQQTNSTVPPS
APPPTTAATPLPTSFPTLSFGSLLSSATTPSLPMSAGRSTEEATSSALPEKPGDSEVSASAASLLEEQQSAQLPQAPPQTSDSVKKEPVL
AQPAVSNSGTAASSTSLVALSAEATPATTGVPDARTEAVPPASSFSVPGQTAVTAAAISSAGPVAVETSSTPIASSTTSIVAPGPSAEAA
AFGTVTSGSSVFAQPPAASSSSAFNQLTNNTATAPSATPVFGQVAASTAPSLFGQQTGSTASTAAATPQVSSSGFSSPAFGTTAPGVFGQ
TTFGQASVFGQSASSAASVFSFSQPGFSSVPAFGQPASSTPTSTSGSVFGAASSTSSSSSFSFGQSSPNTGGGLFGQSNAPAFGQSPGFG
QGGSVFGGTSAATTTAATSGFSFCQASGFGSSNTGSVFGQAASTGGIVFGQQSSSSSGSVFGSGNTGRGGGFFSGLGGKPSQDAANKNPF
SSASGGFGSTATSNTSNLFGNSGAKTFGGFASSSFGEQKPTGTFSSGGGSVASQGFGFSSPNKTGGFGAAPVFGSPPTFGGSPGFGGVPA
FGSAPAFTSPLGSTGGKVFGEGTAAASAGGFGFGSSSNTTSFGTLASQNAPTFGSLSQQTSGFGTQSSGFSGFGSGTGGFSFGSNNSSVQ

--------------------------------------------------------------

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr9:139438476/chr9:134062675)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
NOTCH1

P46531

NUP214

P35658

FUNCTION: Functions as a receptor for membrane-bound ligands Jagged-1 (JAG1), Jagged-2 (JAG2) and Delta-1 (DLL1) to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs. Involved in angiogenesis; negatively regulates endothelial cell proliferation and migration and angiogenic sprouting. Involved in the maturation of both CD4(+) and CD8(+) cells in the thymus. Important for follicular differentiation and possibly cell fate selection within the follicle. During cerebellar development, functions as a receptor for neuronal DNER and is involved in the differentiation of Bergmann glia. Represses neuronal and myogenic differentiation. May play an essential role in postimplantation development, probably in some aspect of cell specification and/or differentiation. May be involved in mesoderm development, somite formation and neurogenesis. May enhance HIF1A function by sequestering HIF1AN away from HIF1A. Required for the THBS4 function in regulating protective astrogenesis from the subventricular zone (SVZ) niche after injury. Involved in determination of left/right symmetry by modulating the balance between motile and immotile (sensory) cilia at the left-right organiser (LRO). {ECO:0000269|PubMed:20616313}.FUNCTION: Part of the nuclear pore complex (PubMed:9049309). Has a critical role in nucleocytoplasmic transport (PubMed:31178128). May serve as a docking site in the receptor-mediated import of substrates across the nuclear pore complex (PubMed:31178128, PubMed:8108440). {ECO:0000269|PubMed:31178128, ECO:0000269|PubMed:9049309, ECO:0000303|PubMed:8108440}.; FUNCTION: (Microbial infection) Required for capsid disassembly of the human adenovirus 5 (HadV-5) leading to release of the viral genome to the nucleus (in vitro). {ECO:0000269|PubMed:25410864}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneNUP214chr9:139438476chr9:134062675ENST0000035942823361213_20901139.66666666666672091.0Compositional biasNote=Pro/Ser/Thr-rich
TgeneNUP214chr9:139438476chr9:134062675ENST0000041163723361213_20901129.66666666666672081.0Compositional biasNote=Pro/Ser/Thr-rich
TgeneNUP214chr9:139438476chr9:134062675ENST0000045103023361213_20901140.66666666666672092.0Compositional biasNote=Pro/Ser/Thr-rich
TgeneNUP214chr9:139438476chr9:134062675ENST0000035942823361409_20841139.66666666666672091.0RegionNote=18 X 4 AA approximate repeats
TgeneNUP214chr9:139438476chr9:134062675ENST0000035942823361427_20851139.66666666666672091.0RegionNote=11 X 3 AA approximate repeats
TgeneNUP214chr9:139438476chr9:134062675ENST0000041163723361409_20841129.66666666666672081.0RegionNote=18 X 4 AA approximate repeats
TgeneNUP214chr9:139438476chr9:134062675ENST0000041163723361427_20851129.66666666666672081.0RegionNote=11 X 3 AA approximate repeats
TgeneNUP214chr9:139438476chr9:134062675ENST0000045103023361409_20841140.66666666666672092.0RegionNote=18 X 4 AA approximate repeats
TgeneNUP214chr9:139438476chr9:134062675ENST0000045103023361427_20851140.66666666666672092.0RegionNote=11 X 3 AA approximate repeats
TgeneNUP214chr9:139438476chr9:134062675ENST0000035942823361225_12261139.66666666666672091.0Repeat3
TgeneNUP214chr9:139438476chr9:134062675ENST0000035942823361411_14121139.66666666666672091.0Repeat4
TgeneNUP214chr9:139438476chr9:134062675ENST0000035942823361427_14281139.66666666666672091.0Repeat5
TgeneNUP214chr9:139438476chr9:134062675ENST0000035942823361441_14421139.66666666666672091.0Repeat6
TgeneNUP214chr9:139438476chr9:134062675ENST0000035942823361473_14741139.66666666666672091.0Repeat7
TgeneNUP214chr9:139438476chr9:134062675ENST0000035942823361635_16361139.66666666666672091.0Repeat8
TgeneNUP214chr9:139438476chr9:134062675ENST0000035942823361674_16751139.66666666666672091.0Repeat9
TgeneNUP214chr9:139438476chr9:134062675ENST0000035942823361686_16871139.66666666666672091.0Repeat10
TgeneNUP214chr9:139438476chr9:134062675ENST0000035942823361713_17141139.66666666666672091.0Repeat11
TgeneNUP214chr9:139438476chr9:134062675ENST0000035942823361721_17221139.66666666666672091.0Repeat12
TgeneNUP214chr9:139438476chr9:134062675ENST0000035942823361726_17271139.66666666666672091.0Repeat13
TgeneNUP214chr9:139438476chr9:134062675ENST0000035942823361732_17331139.66666666666672091.0Repeat14
TgeneNUP214chr9:139438476chr9:134062675ENST0000035942823361756_17571139.66666666666672091.0Repeat15
TgeneNUP214chr9:139438476chr9:134062675ENST0000035942823361772_17731139.66666666666672091.0Repeat16
TgeneNUP214chr9:139438476chr9:134062675ENST0000035942823361786_17871139.66666666666672091.0Repeat17
TgeneNUP214chr9:139438476chr9:134062675ENST0000035942823361798_17991139.66666666666672091.0Repeat18
TgeneNUP214chr9:139438476chr9:134062675ENST0000035942823361806_18071139.66666666666672091.0Repeat19
TgeneNUP214chr9:139438476chr9:134062675ENST0000035942823361812_18131139.66666666666672091.0Repeat20
TgeneNUP214chr9:139438476chr9:134062675ENST0000035942823361819_18201139.66666666666672091.0Repeat21
TgeneNUP214chr9:139438476chr9:134062675ENST0000035942823361842_18431139.66666666666672091.0Repeat22
TgeneNUP214chr9:139438476chr9:134062675ENST0000035942823361851_18521139.66666666666672091.0Repeat23
TgeneNUP214chr9:139438476chr9:134062675ENST0000035942823361862_18631139.66666666666672091.0Repeat24
TgeneNUP214chr9:139438476chr9:134062675ENST0000035942823361874_18751139.66666666666672091.0Repeat25
TgeneNUP214chr9:139438476chr9:134062675ENST0000035942823361910_19111139.66666666666672091.0Repeat26
TgeneNUP214chr9:139438476chr9:134062675ENST0000035942823361922_19231139.66666666666672091.0Repeat27
TgeneNUP214chr9:139438476chr9:134062675ENST0000035942823361930_19311139.66666666666672091.0Repeat28
TgeneNUP214chr9:139438476chr9:134062675ENST0000035942823361938_19391139.66666666666672091.0Repeat29
TgeneNUP214chr9:139438476chr9:134062675ENST0000035942823361959_19601139.66666666666672091.0Repeat30
TgeneNUP214chr9:139438476chr9:134062675ENST0000035942823361970_19711139.66666666666672091.0Repeat31
TgeneNUP214chr9:139438476chr9:134062675ENST0000035942823361976_19771139.66666666666672091.0Repeat32
TgeneNUP214chr9:139438476chr9:134062675ENST0000035942823361982_19831139.66666666666672091.0Repeat33
TgeneNUP214chr9:139438476chr9:134062675ENST0000035942823361988_19891139.66666666666672091.0Repeat34
TgeneNUP214chr9:139438476chr9:134062675ENST0000035942823361994_19951139.66666666666672091.0Repeat35
TgeneNUP214chr9:139438476chr9:134062675ENST0000035942823362012_20131139.66666666666672091.0Repeat36
TgeneNUP214chr9:139438476chr9:134062675ENST0000035942823362024_20251139.66666666666672091.0Repeat37
TgeneNUP214chr9:139438476chr9:134062675ENST0000035942823362026_20271139.66666666666672091.0Repeat38
TgeneNUP214chr9:139438476chr9:134062675ENST0000035942823362035_20361139.66666666666672091.0Repeat39
TgeneNUP214chr9:139438476chr9:134062675ENST0000035942823362046_20471139.66666666666672091.0Repeat40
TgeneNUP214chr9:139438476chr9:134062675ENST0000035942823362056_20571139.66666666666672091.0Repeat41
TgeneNUP214chr9:139438476chr9:134062675ENST0000035942823362066_20671139.66666666666672091.0Repeat42
TgeneNUP214chr9:139438476chr9:134062675ENST0000035942823362075_20761139.66666666666672091.0Repeat43
TgeneNUP214chr9:139438476chr9:134062675ENST0000035942823362085_20861139.66666666666672091.0Repeat44
TgeneNUP214chr9:139438476chr9:134062675ENST0000041163723361225_12261129.66666666666672081.0Repeat3
TgeneNUP214chr9:139438476chr9:134062675ENST0000041163723361411_14121129.66666666666672081.0Repeat4
TgeneNUP214chr9:139438476chr9:134062675ENST0000041163723361427_14281129.66666666666672081.0Repeat5
TgeneNUP214chr9:139438476chr9:134062675ENST0000041163723361441_14421129.66666666666672081.0Repeat6
TgeneNUP214chr9:139438476chr9:134062675ENST0000041163723361473_14741129.66666666666672081.0Repeat7
TgeneNUP214chr9:139438476chr9:134062675ENST0000041163723361635_16361129.66666666666672081.0Repeat8
TgeneNUP214chr9:139438476chr9:134062675ENST0000041163723361674_16751129.66666666666672081.0Repeat9
TgeneNUP214chr9:139438476chr9:134062675ENST0000041163723361686_16871129.66666666666672081.0Repeat10
TgeneNUP214chr9:139438476chr9:134062675ENST0000041163723361713_17141129.66666666666672081.0Repeat11
TgeneNUP214chr9:139438476chr9:134062675ENST0000041163723361721_17221129.66666666666672081.0Repeat12
TgeneNUP214chr9:139438476chr9:134062675ENST0000041163723361726_17271129.66666666666672081.0Repeat13
TgeneNUP214chr9:139438476chr9:134062675ENST0000041163723361732_17331129.66666666666672081.0Repeat14
TgeneNUP214chr9:139438476chr9:134062675ENST0000041163723361756_17571129.66666666666672081.0Repeat15
TgeneNUP214chr9:139438476chr9:134062675ENST0000041163723361772_17731129.66666666666672081.0Repeat16
TgeneNUP214chr9:139438476chr9:134062675ENST0000041163723361786_17871129.66666666666672081.0Repeat17
TgeneNUP214chr9:139438476chr9:134062675ENST0000041163723361798_17991129.66666666666672081.0Repeat18
TgeneNUP214chr9:139438476chr9:134062675ENST0000041163723361806_18071129.66666666666672081.0Repeat19
TgeneNUP214chr9:139438476chr9:134062675ENST0000041163723361812_18131129.66666666666672081.0Repeat20
TgeneNUP214chr9:139438476chr9:134062675ENST0000041163723361819_18201129.66666666666672081.0Repeat21
TgeneNUP214chr9:139438476chr9:134062675ENST0000041163723361842_18431129.66666666666672081.0Repeat22
TgeneNUP214chr9:139438476chr9:134062675ENST0000041163723361851_18521129.66666666666672081.0Repeat23
TgeneNUP214chr9:139438476chr9:134062675ENST0000041163723361862_18631129.66666666666672081.0Repeat24
TgeneNUP214chr9:139438476chr9:134062675ENST0000041163723361874_18751129.66666666666672081.0Repeat25
TgeneNUP214chr9:139438476chr9:134062675ENST0000041163723361910_19111129.66666666666672081.0Repeat26
TgeneNUP214chr9:139438476chr9:134062675ENST0000041163723361922_19231129.66666666666672081.0Repeat27
TgeneNUP214chr9:139438476chr9:134062675ENST0000041163723361930_19311129.66666666666672081.0Repeat28
TgeneNUP214chr9:139438476chr9:134062675ENST0000041163723361938_19391129.66666666666672081.0Repeat29
TgeneNUP214chr9:139438476chr9:134062675ENST0000041163723361959_19601129.66666666666672081.0Repeat30
TgeneNUP214chr9:139438476chr9:134062675ENST0000041163723361970_19711129.66666666666672081.0Repeat31
TgeneNUP214chr9:139438476chr9:134062675ENST0000041163723361976_19771129.66666666666672081.0Repeat32
TgeneNUP214chr9:139438476chr9:134062675ENST0000041163723361982_19831129.66666666666672081.0Repeat33
TgeneNUP214chr9:139438476chr9:134062675ENST0000041163723361988_19891129.66666666666672081.0Repeat34
TgeneNUP214chr9:139438476chr9:134062675ENST0000041163723361994_19951129.66666666666672081.0Repeat35
TgeneNUP214chr9:139438476chr9:134062675ENST0000041163723362012_20131129.66666666666672081.0Repeat36
TgeneNUP214chr9:139438476chr9:134062675ENST0000041163723362024_20251129.66666666666672081.0Repeat37
TgeneNUP214chr9:139438476chr9:134062675ENST0000041163723362026_20271129.66666666666672081.0Repeat38
TgeneNUP214chr9:139438476chr9:134062675ENST0000041163723362035_20361129.66666666666672081.0Repeat39
TgeneNUP214chr9:139438476chr9:134062675ENST0000041163723362046_20471129.66666666666672081.0Repeat40
TgeneNUP214chr9:139438476chr9:134062675ENST0000041163723362056_20571129.66666666666672081.0Repeat41
TgeneNUP214chr9:139438476chr9:134062675ENST0000041163723362066_20671129.66666666666672081.0Repeat42
TgeneNUP214chr9:139438476chr9:134062675ENST0000041163723362075_20761129.66666666666672081.0Repeat43
TgeneNUP214chr9:139438476chr9:134062675ENST0000041163723362085_20861129.66666666666672081.0Repeat44
TgeneNUP214chr9:139438476chr9:134062675ENST0000045103023361225_12261140.66666666666672092.0Repeat3
TgeneNUP214chr9:139438476chr9:134062675ENST0000045103023361411_14121140.66666666666672092.0Repeat4
TgeneNUP214chr9:139438476chr9:134062675ENST0000045103023361427_14281140.66666666666672092.0Repeat5
TgeneNUP214chr9:139438476chr9:134062675ENST0000045103023361441_14421140.66666666666672092.0Repeat6
TgeneNUP214chr9:139438476chr9:134062675ENST0000045103023361473_14741140.66666666666672092.0Repeat7
TgeneNUP214chr9:139438476chr9:134062675ENST0000045103023361635_16361140.66666666666672092.0Repeat8
TgeneNUP214chr9:139438476chr9:134062675ENST0000045103023361674_16751140.66666666666672092.0Repeat9
TgeneNUP214chr9:139438476chr9:134062675ENST0000045103023361686_16871140.66666666666672092.0Repeat10
TgeneNUP214chr9:139438476chr9:134062675ENST0000045103023361713_17141140.66666666666672092.0Repeat11
TgeneNUP214chr9:139438476chr9:134062675ENST0000045103023361721_17221140.66666666666672092.0Repeat12
TgeneNUP214chr9:139438476chr9:134062675ENST0000045103023361726_17271140.66666666666672092.0Repeat13
TgeneNUP214chr9:139438476chr9:134062675ENST0000045103023361732_17331140.66666666666672092.0Repeat14
TgeneNUP214chr9:139438476chr9:134062675ENST0000045103023361756_17571140.66666666666672092.0Repeat15
TgeneNUP214chr9:139438476chr9:134062675ENST0000045103023361772_17731140.66666666666672092.0Repeat16
TgeneNUP214chr9:139438476chr9:134062675ENST0000045103023361786_17871140.66666666666672092.0Repeat17
TgeneNUP214chr9:139438476chr9:134062675ENST0000045103023361798_17991140.66666666666672092.0Repeat18
TgeneNUP214chr9:139438476chr9:134062675ENST0000045103023361806_18071140.66666666666672092.0Repeat19
TgeneNUP214chr9:139438476chr9:134062675ENST0000045103023361812_18131140.66666666666672092.0Repeat20
TgeneNUP214chr9:139438476chr9:134062675ENST0000045103023361819_18201140.66666666666672092.0Repeat21
TgeneNUP214chr9:139438476chr9:134062675ENST0000045103023361842_18431140.66666666666672092.0Repeat22
TgeneNUP214chr9:139438476chr9:134062675ENST0000045103023361851_18521140.66666666666672092.0Repeat23
TgeneNUP214chr9:139438476chr9:134062675ENST0000045103023361862_18631140.66666666666672092.0Repeat24
TgeneNUP214chr9:139438476chr9:134062675ENST0000045103023361874_18751140.66666666666672092.0Repeat25
TgeneNUP214chr9:139438476chr9:134062675ENST0000045103023361910_19111140.66666666666672092.0Repeat26
TgeneNUP214chr9:139438476chr9:134062675ENST0000045103023361922_19231140.66666666666672092.0Repeat27
TgeneNUP214chr9:139438476chr9:134062675ENST0000045103023361930_19311140.66666666666672092.0Repeat28
TgeneNUP214chr9:139438476chr9:134062675ENST0000045103023361938_19391140.66666666666672092.0Repeat29
TgeneNUP214chr9:139438476chr9:134062675ENST0000045103023361959_19601140.66666666666672092.0Repeat30
TgeneNUP214chr9:139438476chr9:134062675ENST0000045103023361970_19711140.66666666666672092.0Repeat31
TgeneNUP214chr9:139438476chr9:134062675ENST0000045103023361976_19771140.66666666666672092.0Repeat32
TgeneNUP214chr9:139438476chr9:134062675ENST0000045103023361982_19831140.66666666666672092.0Repeat33
TgeneNUP214chr9:139438476chr9:134062675ENST0000045103023361988_19891140.66666666666672092.0Repeat34
TgeneNUP214chr9:139438476chr9:134062675ENST0000045103023361994_19951140.66666666666672092.0Repeat35
TgeneNUP214chr9:139438476chr9:134062675ENST0000045103023362012_20131140.66666666666672092.0Repeat36
TgeneNUP214chr9:139438476chr9:134062675ENST0000045103023362024_20251140.66666666666672092.0Repeat37
TgeneNUP214chr9:139438476chr9:134062675ENST0000045103023362026_20271140.66666666666672092.0Repeat38
TgeneNUP214chr9:139438476chr9:134062675ENST0000045103023362035_20361140.66666666666672092.0Repeat39
TgeneNUP214chr9:139438476chr9:134062675ENST0000045103023362046_20471140.66666666666672092.0Repeat40
TgeneNUP214chr9:139438476chr9:134062675ENST0000045103023362056_20571140.66666666666672092.0Repeat41
TgeneNUP214chr9:139438476chr9:134062675ENST0000045103023362066_20671140.66666666666672092.0Repeat42
TgeneNUP214chr9:139438476chr9:134062675ENST0000045103023362075_20761140.66666666666672092.0Repeat43
TgeneNUP214chr9:139438476chr9:134062675ENST0000045103023362085_20861140.66666666666672092.0Repeat44

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneNOTCH1chr9:139438476chr9:134062675ENST00000277541-2341575_157846.6666666666666642556.0Compositional biasNote=Poly-Val
HgeneNOTCH1chr9:139438476chr9:134062675ENST00000277541-2341661_166446.6666666666666642556.0Compositional biasNote=Poly-Arg
HgeneNOTCH1chr9:139438476chr9:134062675ENST00000277541-2341728_173146.6666666666666642556.0Compositional biasNote=Poly-Pro
HgeneNOTCH1chr9:139438476chr9:134062675ENST00000277541-2341740_174346.6666666666666642556.0Compositional biasNote=Poly-Ala
HgeneNOTCH1chr9:139438476chr9:134062675ENST00000277541-2341901_190446.6666666666666642556.0Compositional biasNote=Poly-Glu
HgeneNOTCH1chr9:139438476chr9:134062675ENST00000277541-2342259_226246.6666666666666642556.0Compositional biasNote=Poly-Gly
HgeneNOTCH1chr9:139438476chr9:134062675ENST00000277541-2342403_240646.6666666666666642556.0Compositional biasNote=Poly-Gln
HgeneNOTCH1chr9:139438476chr9:134062675ENST00000277541-2342410_241746.6666666666666642556.0Compositional biasNote=Poly-Pro
HgeneNOTCH1chr9:139438476chr9:134062675ENST00000277541-2342521_252446.6666666666666642556.0Compositional biasNote=Poly-Ser
HgeneNOTCH1chr9:139438476chr9:134062675ENST00000277541-2341021_105746.6666666666666642556.0DomainEGF-like 27
HgeneNOTCH1chr9:139438476chr9:134062675ENST00000277541-234102_13946.6666666666666642556.0DomainEGF-like 3
HgeneNOTCH1chr9:139438476chr9:134062675ENST00000277541-2341059_109546.6666666666666642556.0DomainEGF-like 28
HgeneNOTCH1chr9:139438476chr9:134062675ENST00000277541-2341097_114346.6666666666666642556.0DomainEGF-like 29
HgeneNOTCH1chr9:139438476chr9:134062675ENST00000277541-2341145_118146.6666666666666642556.0DomainEGF-like 30
HgeneNOTCH1chr9:139438476chr9:134062675ENST00000277541-2341183_121946.6666666666666642556.0DomainEGF-like 31%3B calcium-binding
HgeneNOTCH1chr9:139438476chr9:134062675ENST00000277541-2341221_126546.6666666666666642556.0DomainEGF-like 32%3B calcium-binding
HgeneNOTCH1chr9:139438476chr9:134062675ENST00000277541-2341267_130546.6666666666666642556.0DomainEGF-like 33
HgeneNOTCH1chr9:139438476chr9:134062675ENST00000277541-2341307_134646.6666666666666642556.0DomainEGF-like 34
HgeneNOTCH1chr9:139438476chr9:134062675ENST00000277541-2341348_138446.6666666666666642556.0DomainEGF-like 35
HgeneNOTCH1chr9:139438476chr9:134062675ENST00000277541-2341387_142646.6666666666666642556.0DomainEGF-like 36
HgeneNOTCH1chr9:139438476chr9:134062675ENST00000277541-234140_17646.6666666666666642556.0DomainEGF-like 4
HgeneNOTCH1chr9:139438476chr9:134062675ENST00000277541-234178_21646.6666666666666642556.0DomainEGF-like 5%3B calcium-binding
HgeneNOTCH1chr9:139438476chr9:134062675ENST00000277541-23420_5846.6666666666666642556.0DomainEGF-like 1
HgeneNOTCH1chr9:139438476chr9:134062675ENST00000277541-234218_25546.6666666666666642556.0DomainEGF-like 6
HgeneNOTCH1chr9:139438476chr9:134062675ENST00000277541-234257_29346.6666666666666642556.0DomainEGF-like 7%3B calcium-binding
HgeneNOTCH1chr9:139438476chr9:134062675ENST00000277541-234295_33346.6666666666666642556.0DomainEGF-like 8%3B calcium-binding
HgeneNOTCH1chr9:139438476chr9:134062675ENST00000277541-234335_37146.6666666666666642556.0DomainEGF-like 9%3B calcium-binding
HgeneNOTCH1chr9:139438476chr9:134062675ENST00000277541-234372_41046.6666666666666642556.0DomainEGF-like 10
HgeneNOTCH1chr9:139438476chr9:134062675ENST00000277541-234412_45046.6666666666666642556.0DomainEGF-like 11%3B calcium-binding
HgeneNOTCH1chr9:139438476chr9:134062675ENST00000277541-234452_48846.6666666666666642556.0DomainEGF-like 12%3B calcium-binding
HgeneNOTCH1chr9:139438476chr9:134062675ENST00000277541-234490_52646.6666666666666642556.0DomainEGF-like 13%3B calcium-binding
HgeneNOTCH1chr9:139438476chr9:134062675ENST00000277541-234528_56446.6666666666666642556.0DomainEGF-like 14%3B calcium-binding
HgeneNOTCH1chr9:139438476chr9:134062675ENST00000277541-234566_60146.6666666666666642556.0DomainEGF-like 15%3B calcium-binding
HgeneNOTCH1chr9:139438476chr9:134062675ENST00000277541-23459_9946.6666666666666642556.0DomainEGF-like 2
HgeneNOTCH1chr9:139438476chr9:134062675ENST00000277541-234603_63946.6666666666666642556.0DomainEGF-like 16%3B calcium-binding
HgeneNOTCH1chr9:139438476chr9:134062675ENST00000277541-234641_67646.6666666666666642556.0DomainEGF-like 17%3B calcium-binding
HgeneNOTCH1chr9:139438476chr9:134062675ENST00000277541-234678_71446.6666666666666642556.0DomainEGF-like 18%3B calcium-binding
HgeneNOTCH1chr9:139438476chr9:134062675ENST00000277541-234716_75146.6666666666666642556.0DomainEGF-like 19%3B calcium-binding
HgeneNOTCH1chr9:139438476chr9:134062675ENST00000277541-234753_78946.6666666666666642556.0DomainEGF-like 20
HgeneNOTCH1chr9:139438476chr9:134062675ENST00000277541-234791_82746.6666666666666642556.0DomainEGF-like 21%3B calcium-binding
HgeneNOTCH1chr9:139438476chr9:134062675ENST00000277541-234829_86746.6666666666666642556.0DomainEGF-like 22
HgeneNOTCH1chr9:139438476chr9:134062675ENST00000277541-234869_90546.6666666666666642556.0DomainEGF-like 23%3B calcium-binding
HgeneNOTCH1chr9:139438476chr9:134062675ENST00000277541-234907_94346.6666666666666642556.0DomainEGF-like 24
HgeneNOTCH1chr9:139438476chr9:134062675ENST00000277541-234945_98146.6666666666666642556.0DomainEGF-like 25%3B calcium-binding
HgeneNOTCH1chr9:139438476chr9:134062675ENST00000277541-234983_101946.6666666666666642556.0DomainEGF-like 26
HgeneNOTCH1chr9:139438476chr9:134062675ENST00000277541-2341947_195546.6666666666666642556.0RegionHIF1AN-binding
HgeneNOTCH1chr9:139438476chr9:134062675ENST00000277541-2342014_202246.6666666666666642556.0RegionHIF1AN-binding
HgeneNOTCH1chr9:139438476chr9:134062675ENST00000277541-2341449_148946.6666666666666642556.0RepeatLNR 1
HgeneNOTCH1chr9:139438476chr9:134062675ENST00000277541-2341490_153146.6666666666666642556.0RepeatLNR 2
HgeneNOTCH1chr9:139438476chr9:134062675ENST00000277541-2341532_157146.6666666666666642556.0RepeatLNR 3
HgeneNOTCH1chr9:139438476chr9:134062675ENST00000277541-2341927_195646.6666666666666642556.0RepeatANK 1
HgeneNOTCH1chr9:139438476chr9:134062675ENST00000277541-2341960_199046.6666666666666642556.0RepeatANK 2
HgeneNOTCH1chr9:139438476chr9:134062675ENST00000277541-2341994_202346.6666666666666642556.0RepeatANK 3
HgeneNOTCH1chr9:139438476chr9:134062675ENST00000277541-2342027_205646.6666666666666642556.0RepeatANK 4
HgeneNOTCH1chr9:139438476chr9:134062675ENST00000277541-2342060_208946.6666666666666642556.0RepeatANK 5
HgeneNOTCH1chr9:139438476chr9:134062675ENST00000277541-2342095_212246.6666666666666642556.0RepeatNote=ANK 6
HgeneNOTCH1chr9:139438476chr9:134062675ENST00000277541-2341757_255546.6666666666666642556.0Topological domainCytoplasmic
HgeneNOTCH1chr9:139438476chr9:134062675ENST00000277541-23419_173546.6666666666666642556.0Topological domainExtracellular
HgeneNOTCH1chr9:139438476chr9:134062675ENST00000277541-2341736_175646.6666666666666642556.0TransmembraneHelical
TgeneNUP214chr9:139438476chr9:134062675ENST000003594282336680_12091139.66666666666672091.0Coiled coilOntology_term=ECO:0000269
TgeneNUP214chr9:139438476chr9:134062675ENST000004116372336680_12091129.66666666666672081.0Coiled coilOntology_term=ECO:0000269
TgeneNUP214chr9:139438476chr9:134062675ENST000004510302336680_12091140.66666666666672092.0Coiled coilOntology_term=ECO:0000269
TgeneNUP214chr9:139438476chr9:134062675ENST000003594282336236_14181139.66666666666672091.0Region44 X 2 AA repeats of F-G
TgeneNUP214chr9:139438476chr9:134062675ENST00000359428233641_4041139.66666666666672091.0RegionNote=Seven-bladed beta propeller
TgeneNUP214chr9:139438476chr9:134062675ENST000003594282336450_5861139.66666666666672091.0Region(Microbial infection) Binds human adenovirus 5 (HAdV-5) protein L3 (hexon)
TgeneNUP214chr9:139438476chr9:134062675ENST000003594282336481_20761139.66666666666672091.0RegionNote=11 X 5 AA approximate repeats
TgeneNUP214chr9:139438476chr9:134062675ENST000003594282336740_7681139.66666666666672091.0RegionNote=Leucine-zipper 1
TgeneNUP214chr9:139438476chr9:134062675ENST000003594282336861_8821139.66666666666672091.0RegionNote=Leucine-zipper 2
TgeneNUP214chr9:139438476chr9:134062675ENST000004116372336236_14181129.66666666666672081.0Region44 X 2 AA repeats of F-G
TgeneNUP214chr9:139438476chr9:134062675ENST00000411637233641_4041129.66666666666672081.0RegionNote=Seven-bladed beta propeller
TgeneNUP214chr9:139438476chr9:134062675ENST000004116372336450_5861129.66666666666672081.0Region(Microbial infection) Binds human adenovirus 5 (HAdV-5) protein L3 (hexon)
TgeneNUP214chr9:139438476chr9:134062675ENST000004116372336481_20761129.66666666666672081.0RegionNote=11 X 5 AA approximate repeats
TgeneNUP214chr9:139438476chr9:134062675ENST000004116372336740_7681129.66666666666672081.0RegionNote=Leucine-zipper 1
TgeneNUP214chr9:139438476chr9:134062675ENST000004116372336861_8821129.66666666666672081.0RegionNote=Leucine-zipper 2
TgeneNUP214chr9:139438476chr9:134062675ENST000004510302336236_14181140.66666666666672092.0Region44 X 2 AA repeats of F-G
TgeneNUP214chr9:139438476chr9:134062675ENST00000451030233641_4041140.66666666666672092.0RegionNote=Seven-bladed beta propeller
TgeneNUP214chr9:139438476chr9:134062675ENST000004510302336450_5861140.66666666666672092.0Region(Microbial infection) Binds human adenovirus 5 (HAdV-5) protein L3 (hexon)
TgeneNUP214chr9:139438476chr9:134062675ENST000004510302336481_20761140.66666666666672092.0RegionNote=11 X 5 AA approximate repeats
TgeneNUP214chr9:139438476chr9:134062675ENST000004510302336740_7681140.66666666666672092.0RegionNote=Leucine-zipper 1
TgeneNUP214chr9:139438476chr9:134062675ENST000004510302336861_8821140.66666666666672092.0RegionNote=Leucine-zipper 2
TgeneNUP214chr9:139438476chr9:134062675ENST000003594282336151_1931139.66666666666672091.0RepeatNote=Blade 3
TgeneNUP214chr9:139438476chr9:134062675ENST000003594282336194_2391139.66666666666672091.0RepeatNote=Blade 4
TgeneNUP214chr9:139438476chr9:134062675ENST000003594282336240_3031139.66666666666672091.0RepeatNote=Blade 5
TgeneNUP214chr9:139438476chr9:134062675ENST000003594282336304_3591139.66666666666672091.0RepeatNote=Blade 6
TgeneNUP214chr9:139438476chr9:134062675ENST000003594282336360_4041139.66666666666672091.0RepeatNote=Blade 7
TgeneNUP214chr9:139438476chr9:134062675ENST00000359428233641_931139.66666666666672091.0RepeatNote=Blade 1
TgeneNUP214chr9:139438476chr9:134062675ENST000003594282336484_4851139.66666666666672091.0Repeat1
TgeneNUP214chr9:139438476chr9:134062675ENST000003594282336548_5491139.66666666666672091.0Repeat2
TgeneNUP214chr9:139438476chr9:134062675ENST00000359428233694_1501139.66666666666672091.0RepeatNote=Blade 2
TgeneNUP214chr9:139438476chr9:134062675ENST000004116372336151_1931129.66666666666672081.0RepeatNote=Blade 3
TgeneNUP214chr9:139438476chr9:134062675ENST000004116372336194_2391129.66666666666672081.0RepeatNote=Blade 4
TgeneNUP214chr9:139438476chr9:134062675ENST000004116372336240_3031129.66666666666672081.0RepeatNote=Blade 5
TgeneNUP214chr9:139438476chr9:134062675ENST000004116372336304_3591129.66666666666672081.0RepeatNote=Blade 6
TgeneNUP214chr9:139438476chr9:134062675ENST000004116372336360_4041129.66666666666672081.0RepeatNote=Blade 7
TgeneNUP214chr9:139438476chr9:134062675ENST00000411637233641_931129.66666666666672081.0RepeatNote=Blade 1
TgeneNUP214chr9:139438476chr9:134062675ENST000004116372336484_4851129.66666666666672081.0Repeat1
TgeneNUP214chr9:139438476chr9:134062675ENST000004116372336548_5491129.66666666666672081.0Repeat2
TgeneNUP214chr9:139438476chr9:134062675ENST00000411637233694_1501129.66666666666672081.0RepeatNote=Blade 2
TgeneNUP214chr9:139438476chr9:134062675ENST000004510302336151_1931140.66666666666672092.0RepeatNote=Blade 3
TgeneNUP214chr9:139438476chr9:134062675ENST000004510302336194_2391140.66666666666672092.0RepeatNote=Blade 4
TgeneNUP214chr9:139438476chr9:134062675ENST000004510302336240_3031140.66666666666672092.0RepeatNote=Blade 5
TgeneNUP214chr9:139438476chr9:134062675ENST000004510302336304_3591140.66666666666672092.0RepeatNote=Blade 6
TgeneNUP214chr9:139438476chr9:134062675ENST000004510302336360_4041140.66666666666672092.0RepeatNote=Blade 7
TgeneNUP214chr9:139438476chr9:134062675ENST00000451030233641_931140.66666666666672092.0RepeatNote=Blade 1
TgeneNUP214chr9:139438476chr9:134062675ENST000004510302336484_4851140.66666666666672092.0Repeat1
TgeneNUP214chr9:139438476chr9:134062675ENST000004510302336548_5491140.66666666666672092.0Repeat2
TgeneNUP214chr9:139438476chr9:134062675ENST00000451030233694_1501140.66666666666672092.0RepeatNote=Blade 2


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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors
NUP214ZFP36, XPO1, NUP107, NXF2, NXF1, XPO5, CRM1, KAP104, IPO5, G3BP1, G3BP2, RAE1, APC, HDAC4, HDAC5, HDAC9, NUP88, SMAD1, Plk1, Nup88, Nup188, Nup214, CLEC4G, SMAD2, SMAD3, SMAD4, SIRT7, RANBP2, CUL3, CUL2, rev, NUPL2, NUP214, MEX67, ACOT13, PNPT1, HSPA1L, VPS4B, S100A6, EEF1A1, STRIP1, RPL19, NDUFA7, ITGA4, SOX2, LMNA, FBXO6, CUL7, OBSL1, NUP62, CLEC11A, DDX19A, KCMF1, CFL1, CSRP1, DYNC1LI1, TRIM28, TXNDC9, NTRK1, IFI16, NUP85, NUP35, KPNB1, UBE2I, NUPL1, NUP153, SEH1L, Ranbp2, Ube2i, Rcc1, Nup107, Kifc1, Nup155, Nup98, C11orf30, CDH1, RAN, FXR2, EMILIN1, SERPINB2, BRCA1, ORF10, CTNNB1, CUL4B, RNF31, ESR2, EZH2, SUZ12, MYC, CDK9, VCP, KIAA1429, NR2C2, HIST1H4A, PTPDC1, RHBDD1, RHBDF2, nsp9, BIRC3, LMBR1L, PLEKHA4, CYLD, ORF6, IMMP1L, IMMP2L, CTIF, DDX19B, GLE1, FARP1, Myo9b, ITSN1, PLEKHG6, ACACA, SUMO2, NFX1, NUPR1, DYRK1A, NUP155, SYNE3, NAA40, NXT2, SLFN11, CCNF, TAX1BP1, SIRT6, DVL2, ETV6,


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
NOTCH1
NUP214all structure


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgeneNOTCH1chr9:139438476chr9:134062675ENST00000277541-234420_42146.6666666666666642556.0DLL4
HgeneNOTCH1chr9:139438476chr9:134062675ENST00000277541-234448_45246.6666666666666642556.0DLL4
HgeneNOTCH1chr9:139438476chr9:134062675ENST00000277541-2341728_176046.6666666666666642556.0PSEN1


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Related Drugs to NOTCH1-NUP214


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to NOTCH1-NUP214


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneNUP214C0025958Microcephaly1GENOMICS_ENGLAND
TgeneNUP214C0543888Epileptic encephalopathy1GENOMICS_ENGLAND
TgeneNUP214C1836830Developmental regression1GENOMICS_ENGLAND
TgeneNUP214C1961099Precursor T-Cell Lymphoblastic Leukemia-Lymphoma1ORPHANET