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Fusion Protein:NOTCH2-MACF1 |
Fusion Protein Summary |
 Fusion gene summary |
| Fusion partner gene information | Fusion gene name: NOTCH2-MACF1 | FusionPDB ID: 59734 | FusionGDB2.0 ID: 59734 | Hgene | Tgene | Gene symbol | NOTCH2 | MACF1 | Gene ID | 4853 | 23499 |
| Gene name | notch receptor 2 | microtubule actin crosslinking factor 1 | |
| Synonyms | AGS2|HJCYS|hN2 | ABP620|ACF7|LIS9|MACF|OFC4 | |
| Cytomap | 1p12 | 1p34.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | neurogenic locus notch homolog protein 2Notch homolog 2notch 2 | microtubule-actin cross-linking factor 1620 kDa actin binding proteinactin cross-linking family protein 7macrophin 1 isoformtrabeculin-alpha | |
| Modification date | 20200329 | 20200313 | |
| UniProtAcc | P0DPK3 | Q9UPN3 | |
| Ensembl transtripts involved in fusion gene | ENST ids | ENST00000256646, ENST00000602566, ENST00000493703, | ENST00000476350, ENST00000289893, ENST00000484793, ENST00000536367, ENST00000602421, ENST00000317713, ENST00000361689, ENST00000372915, ENST00000539005, ENST00000545844, ENST00000564288, ENST00000567887, |
| Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0) | * DoF score | 26 X 22 X 14=8008 | 24 X 23 X 9=4968 |
| # samples | 35 | 24 | |
| ** MAII score | log2(35/8008*10)=-4.51601514700366 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(24/4968*10)=-4.37155886261196 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context (manual curation of fusion genes in FusionPDB) | PubMed: NOTCH2 [Title/Abstract] AND MACF1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0) | NOTCH2(120572529)-MACF1(39775242), # samples:1 | ||
| Anticipated loss of major functional domain due to fusion event. | NOTCH2-MACF1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. NOTCH2-MACF1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. NOTCH2-MACF1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. NOTCH2-MACF1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. NOTCH2-MACF1 seems lost the major protein functional domain in Hgene partner, which is a CGC due to the frame-shifted ORF. NOTCH2-MACF1 seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF. NOTCH2-MACF1 seems lost the major protein functional domain in Hgene partner, which is a tumor suppressor due to the frame-shifted ORF. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | NOTCH2 | GO:0007050 | cell cycle arrest | 11306509 |
| Hgene | NOTCH2 | GO:0007219 | Notch signaling pathway | 11306509|25985737 |
| Hgene | NOTCH2 | GO:0010629 | negative regulation of gene expression | 11306509 |
| Hgene | NOTCH2 | GO:0010838 | positive regulation of keratinocyte proliferation | 18469519 |
| Hgene | NOTCH2 | GO:0045967 | negative regulation of growth rate | 11306509 |
| Hgene | NOTCH2 | GO:0046579 | positive regulation of Ras protein signal transduction | 11306509 |
| Hgene | NOTCH2 | GO:0070374 | positive regulation of ERK1 and ERK2 cascade | 11306509 |
| Hgene | NOTCH2 | GO:2000249 | regulation of actin cytoskeleton reorganization | 18469519 |
| Tgene | MACF1 | GO:0030334 | regulation of cell migration | 27693509 |
| Tgene | MACF1 | GO:0043001 | Golgi to plasma membrane protein transport | 15265687 |
| Tgene | MACF1 | GO:0045773 | positive regulation of axon extension | 22705394 |
| Tgene | MACF1 | GO:0051893 | regulation of focal adhesion assembly | 27693509 |
| Fusion gene breakpoints across NOTCH2 (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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| Fusion gene breakpoints across MACF1 (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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Fusion Gene Sample Information |
| Fusion gene information from FusionGDB2.0. |
| Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChimerDB4 | BRCA | TCGA-A2-A0YE-01A | NOTCH2 | chr1 | 120572529 | - | MACF1 | chr1 | 39775242 | + |
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Fusion ORF Analysis |
| Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
| ENST00000256646 | NOTCH2 | chr1 | 120572529 | - | ENST00000545844 | MACF1 | chr1 | 39775242 | + | 15187 | 375 | 16 | 13863 | 4615 |
| ENST00000256646 | NOTCH2 | chr1 | 120572529 | - | ENST00000567887 | MACF1 | chr1 | 39775242 | + | 21637 | 375 | 16 | 20253 | 6745 |
| ENST00000256646 | NOTCH2 | chr1 | 120572529 | - | ENST00000372915 | MACF1 | chr1 | 39775242 | + | 20924 | 375 | 16 | 19737 | 6573 |
| ENST00000256646 | NOTCH2 | chr1 | 120572529 | - | ENST00000361689 | MACF1 | chr1 | 39775242 | + | 15057 | 375 | 16 | 13863 | 4615 |
| ENST00000256646 | NOTCH2 | chr1 | 120572529 | - | ENST00000539005 | MACF1 | chr1 | 39775242 | + | 14797 | 375 | 16 | 13473 | 4485 |
| ENST00000256646 | NOTCH2 | chr1 | 120572529 | - | ENST00000317713 | MACF1 | chr1 | 39775242 | + | 15187 | 375 | 16 | 13863 | 4615 |
| ENST00000256646 | NOTCH2 | chr1 | 120572529 | - | ENST00000564288 | MACF1 | chr1 | 39775242 | + | 21637 | 375 | 16 | 20253 | 6745 |
| DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
| ENST00000256646 | ENST00000545844 | NOTCH2 | chr1 | 120572529 | - | MACF1 | chr1 | 39775242 | + | 0.006554564 | 0.9934455 |
| ENST00000256646 | ENST00000567887 | NOTCH2 | chr1 | 120572529 | - | MACF1 | chr1 | 39775242 | + | 0.004203092 | 0.9957969 |
| ENST00000256646 | ENST00000372915 | NOTCH2 | chr1 | 120572529 | - | MACF1 | chr1 | 39775242 | + | 0.004229667 | 0.9957703 |
| ENST00000256646 | ENST00000361689 | NOTCH2 | chr1 | 120572529 | - | MACF1 | chr1 | 39775242 | + | 0.00693754 | 0.99306244 |
| ENST00000256646 | ENST00000539005 | NOTCH2 | chr1 | 120572529 | - | MACF1 | chr1 | 39775242 | + | 0.006489898 | 0.99351007 |
| ENST00000256646 | ENST00000317713 | NOTCH2 | chr1 | 120572529 | - | MACF1 | chr1 | 39775242 | + | 0.006614788 | 0.99338526 |
| ENST00000256646 | ENST00000564288 | NOTCH2 | chr1 | 120572529 | - | MACF1 | chr1 | 39775242 | + | 0.004203092 | 0.9957969 |
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Fusion Amino Acid Sequences |
| For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
| >FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP >59734_59734_1_NOTCH2-MACF1_NOTCH2_chr1_120572529_ENST00000256646_MACF1_chr1_39775242_ENST00000317713_length(amino acids)=4615AA_BP=120 MRRRPRSGGLGARGVEAFAPGLRSVAPGPEPLKQEEGRREWGSSIGTPSPCGSAQAAAAAAEEEATEKMPALRPALLWALLALWLCCAAP AHALQCRDGYEPCVNEGMCVTYHNGTGYCKVEQSYQKVMALWHQLHVNTKSLISWNYLRKDLDLVQTWNLEKLRSSAPGECHQIMKNLQA HYEDFLQDSRDSVLFSVADRLRLEEEVEACKARFQHLMKSMENEDKEETVAKMYISELKNIRLRLEEYEQRVVKRIQSLASSRTDRDAWQ DNALRIAEQEHTQEDLQQLRSDLDAVSMKCDSFLHQSPSSSSVPTLRSELNLLVEKMDHVYGLSTVYLNKLKTVDVIVRSIQDAELLVKG YEIKLSQEEVVLADLSALEAHWSTLRHWLSDVKDKNSVFSVLDEEIAKAKVVAEQMSRLTPERNLDLERYQEKGSQLQERWHRVIAQLEI RQSELESIQEVLGDYRACHGTLIKWIEETTAQQEMMKPGQAEDSRVLSEQLSQQTALFAEIERNQTKLDQCQKFSQQYSTIVKDYELQLM TYKAFVESQQKSPGKRRRMLSSSDAITQEFMDLRTRYTALVTLTTQHVKYISDALRRLEEEEKVVEEEKQEHVEKVKELLGWVSTLARNT QGKATSSETKESTDIEKAILEQQVLSEELTTKKEQVSEAIKTSQIFLAKHGHKLSEKEKKQISEQLNALNKAYHDLCDGSANQLQQLQSQ LAHQTEQKTLQKQQNTCHQQLEDLCSWVGQAERALAGHQGRTTQQDLSALQKNQSDLKDLQDDIQNRATSFATVVKDIEGFMEENQTKLS PRELTALREKLHQAKEQYEALQEETRVAQKELEEAVTSALQQETEKSKAAKELAENKKKIDALLDWVTSVGSSGGQLLTNLPGMEQLSGA SLEKGALDTTDGYMGVNQAPEKLDKQCEMMKARHQELLSQQQNFILATQSAQAFLDQHGHNLTPEEQQMLQQKLGELKEQYSTSLAQSEA ELKQVQTLQDELQKFLQDHKEFESWLERSEKELENMHKGGSSPETLPSLLKRQGSFSEDVISHKGDLRFVTISGQKVLDMENSFKEGKEP SEIGNLVKDKLKDATERYTALHSKCTRLGSHLNMLLGQYHQFQNSADSLQAWMQACEANVEKLLSDTVASDPGVLQEQLATTKQLQEELA EHQVPVEKLQKVARDIMEIEGEPAPDHRHVQETTDSILSHFQSLSYSLAERSSLLQKAIAQSQSVQESLESLLQSIGEVEQNLEGKQVSS LSSGVIQEALATNMKLKQDIARQKSSLEATREMVTRFMETADSTTAAVLQGKLAEVSQRFEQLCLQQQEKESSLKKLLPQAEMFEHLSGK LQQFMENKSRMLASGNQPDQDITHFFQQIQELNLEMEDQQENLDTLEHLVTELSSCGFALDLCQHQDRVQNLRKDFTELQKTVKEREKDA SSCQEQLDEFRKLVRTFQKWLKETEGSIPPTETSMSAKELEKQIEHLKSLLDDWASKGTLVEEINCKGTSLENLIMEITAPDSQGKTGSI LPSVGSSVGSVNGYHTCKDLTEIQCDMSDVNLKYEKLGGVLHERQESLQAILNRMEEVHKEANSVLQWLESKEEVLKSMDAMSSPTKTET VKAQAESNKAFLAELEQNSPKIQKVKEALAGLLVTYPNSQEAENWKKIQEELNSRWERATEVTVARQRQLEESASHLACFQAAESQLRPW LMEKELMMGVLGPLSIDPNMLNAQKQQVQFMLKEFEARRQQHEQLNEAAQGILTGPGDVSLSTSQVQKELQSINQKWVELTDKLNSRSSQ IDQAIVKSTQYQELLQDLSEKVRAVGQRLSVQSAISTQPEAVKQQLEETSEIRSDLEQLDHEVKEAQTLCDELSVLIGEQYLKDELKKRL ETVALPLQGLEDLAADRINRLQAALASTQQFQQMFDELRTWLDDKQSQQAKNCPISAKLERLQSQLQENEEFQKSLNQHSGSYEVIVAEG ESLLLSVPPGEEKRTLQNQLVELKNHWEELSKKTADRQSRLKDCMQKAQKYQWHVEDLVPWIEDCKAKMSELRVTLDPVQLESSLLRSKA MLNEVEKRRSLLEILNSAADILINSSEADEDGIRDEKAGINQNMDAVTEELQAKTGSLEEMTQRLREFQESFKNIEKKVEGAKHQLEIFD ALGSQACSNKNLEKLRAQQEVLQALEPQVDYLRNFTQGLVEDAPDGSDASQLLHQAEVAQQEFLEVKQRVNSGCVMMENKLEGIGQFHCR VREMFSQLADLDDELDGMGAIGRDTDSLQSQIEDVRLFLNKIHVLKLDIEASEAECRHMLEEEGTLDLLGLKRELEALNKQCGKLTERGK ARQEQLELTLGRVEDFYRKLKGLNDATTAAEEAEALQWVVGTEVEIINQQLADFKMFQKEQVDPLQMKLQQVNGLGQGLIQSAGKDCDVQ GLEHDMEEINARWNTLNKKVAQRIAQLQEALLHCGKFQDALEPLLSWLADTEELIANQKPPSAEYKVVKAQIQEQKLLQRLLDDRKATVD MLQAEGGRIAQSAELADREKITGQLESLESRWTELLSKAAARQKQLEDILVLAKQFHETAEPISDFLSVTEKKLANSEPVGTQTAKIQQQ IIRHKALEEDIENHATDVHQAVKIGQSLSSLTSPAEQGVLSEKIDSLQARYSEIQDRCCRKAALLDQALSNARLFGEDEVEVLNWLAEVE DKLSSVFVKDFKQDVLHRQHADHLALNEEIVNRKKNVDQAIKNGQALLKQTTGEEVLLIQEKLDGIKTRYADITVTSSKALRTLEQARQL ATKFQSTYEELTGWLREVEEELATSGGQSPTGEQIPQFQQRQKELKKEVMEHRLVLDTVNEVSRALLELVPWRAREGLDKLVSDANEQYK LVSDTIGQRVDEIDAAIQRSQQYEQAADAELAWVAETKRKLMALGPIRLEQDQTTAQLQVQKAFSIDIIRHKDSMDELFSHRSEIFGTCG EEQKTVLQEKTESLIQQYEAISLLNSERYARLERAQVLVNQFWETYEELSPWIEETRALIAQLPSPAIDHEQLRQQQEEMRQLRESIAEH KPHIDKLLKIGPQLKELNPEEGEMVEEKYQKAENMYAQIKEEVRQRALALDEAVSQSTQVSQFHDKIEPMLETLENLSSRLRMPPLIPAE VDKIRECISDNKSATVELEKLQPSFEALKRRGEELIGRSQGADKDLAAKEIQDKLDQMVFFWEDIKARAEEREIKFLDVLELAEKFWYDM AALLTTIKDTQDIVHDLESPGIDPSIIKQQVEAAETIKEETDGLHEELEFIRILGADLIFACGETEKPEVRKSIDEMNNAWENLNKTWKE RLEKLEDAMQAAVQYQDTLQAMFDWLDNTVIKLCTMPPVGTDLNTVKDQLNEMKEFKVEVYQQQIEMEKLNHQGELMLKKATDETDRDII REPLTELKHLWENLGEKIAHRQHKLEGALLALGQFQHALEELMSWLTHTEELLDAQRPISGDPKVIEVELAKHHVLKNDVLAHQATVETV NKAGNELLESSAGDDASSLRSRLEAMNQCWESVLQKTEEREQQLQSTLQQAQGFHSEIEDFLLELTRMESQLSASKPTGGLPETAREQLD THMELYSQLKAKEETYNQLLDKGRLMLLSRDDSGSGSKTEQSVALLEQKWHVVSSKMEERKSKLEEALNLATEFQNSLQEFINWLTLAEQ SLNIASPPSLILNTVLSQIEEHKVFANEVNAHRDQIIELDQTGNQLKFLSQKQDVVLIKNLLVSVQSRWEKVVQRSIERGRSLDDARKRA KQFHEAWKKLIDWLEDAESHLDSELEISNDPDKIKLQLSKHKEFQKTLGGKQPVYDTTIRTGRALKEKTLLPEDSQKLDNFLGEVRDKWD TVCGKSVERQHKLEEALLFSGQFMDALQALVDWLYKVEPQLAEDQPVHGDLDLVMNLMDAHKVFQKELGKRTGTVQVLKRSGRELIENSR DDTTWVKGQLQELSTRWDTVCKLSVSKQSRLEQALKQAEVFRDTVHMLLEWLSEAEQTLRFRGALPDDTEALQSLIDTHKEFMKKVEEKR VDVNSAVAMGEVILAVCHPDCITTIKHWITIIRARFEEVLTWAKQHQQRLETALSELVANAELLEELLAWIQWAETTLIQRDQEPIPQNI DRVKALIAEHQTFMEEMTRKQPDVDRVTKTYKRKNIEPTHAPFIEKSRSGGRKSLSQPTPPPMPILSQSEAKNPRINQLSARWQQVWLLA LERQRKLNDALDRLEELKEFANFDFDVWRKKYMRWMNHKKSRVMDFFRRIDKDQDGKITRQEFIDGILASKFPTTKLEMTAVADIFDRDG DGYIDYYEFVAALHPNKDAYRPTTDADKIEDEVTRQVAQCKCAKRFQVEQIGENKYRFGDSQQLRLVRILRSTVMVRVGGGWMALDEFLV KNDPCRARGRTNIELREKFILPEGASQGMTPFRSRGRRSKPSSRAASPTRSSSSASQSNHSCTSMPSSPATPASGTKVIPSSGSKLKRPT PTFHSSRTSLAGDTSNSSSPASTGAKTNRADPKKSASRPGSRAGSRAGSRASSRRGSDASDFDLLETQSACSDTSESSAAGGQGNSRRGL -------------------------------------------------------------- >59734_59734_2_NOTCH2-MACF1_NOTCH2_chr1_120572529_ENST00000256646_MACF1_chr1_39775242_ENST00000361689_length(amino acids)=4615AA_BP=120 MRRRPRSGGLGARGVEAFAPGLRSVAPGPEPLKQEEGRREWGSSIGTPSPCGSAQAAAAAAEEEATEKMPALRPALLWALLALWLCCAAP AHALQCRDGYEPCVNEGMCVTYHNGTGYCKVEQSYQKVMALWHQLHVNTKSLISWNYLRKDLDLVQTWNLEKLRSSAPGECHQIMKNLQA HYEDFLQDSRDSVLFSVADRLRLEEEVEACKARFQHLMKSMENEDKEETVAKMYISELKNIRLRLEEYEQRVVKRIQSLASSRTDRDAWQ DNALRIAEQEHTQEDLQQLRSDLDAVSMKCDSFLHQSPSSSSVPTLRSELNLLVEKMDHVYGLSTVYLNKLKTVDVIVRSIQDAELLVKG YEIKLSQEEVVLADLSALEAHWSTLRHWLSDVKDKNSVFSVLDEEIAKAKVVAEQMSRLTPERNLDLERYQEKGSQLQERWHRVIAQLEI RQSELESIQEVLGDYRACHGTLIKWIEETTAQQEMMKPGQAEDSRVLSEQLSQQTALFAEIERNQTKLDQCQKFSQQYSTIVKDYELQLM TYKAFVESQQKSPGKRRRMLSSSDAITQEFMDLRTRYTALVTLTTQHVKYISDALRRLEEEEKVVEEEKQEHVEKVKELLGWVSTLARNT QGKATSSETKESTDIEKAILEQQVLSEELTTKKEQVSEAIKTSQIFLAKHGHKLSEKEKKQISEQLNALNKAYHDLCDGSANQLQQLQSQ LAHQTEQKTLQKQQNTCHQQLEDLCSWVGQAERALAGHQGRTTQQDLSALQKNQSDLKDLQDDIQNRATSFATVVKDIEGFMEENQTKLS PRELTALREKLHQAKEQYEALQEETRVAQKELEEAVTSALQQETEKSKAAKELAENKKKIDALLDWVTSVGSSGGQLLTNLPGMEQLSGA SLEKGALDTTDGYMGVNQAPEKLDKQCEMMKARHQELLSQQQNFILATQSAQAFLDQHGHNLTPEEQQMLQQKLGELKEQYSTSLAQSEA ELKQVQTLQDELQKFLQDHKEFESWLERSEKELENMHKGGSSPETLPSLLKRQGSFSEDVISHKGDLRFVTISGQKVLDMENSFKEGKEP SEIGNLVKDKLKDATERYTALHSKCTRLGSHLNMLLGQYHQFQNSADSLQAWMQACEANVEKLLSDTVASDPGVLQEQLATTKQLQEELA EHQVPVEKLQKVARDIMEIEGEPAPDHRHVQETTDSILSHFQSLSYSLAERSSLLQKAIAQSQSVQESLESLLQSIGEVEQNLEGKQVSS LSSGVIQEALATNMKLKQDIARQKSSLEATREMVTRFMETADSTTAAVLQGKLAEVSQRFEQLCLQQQEKESSLKKLLPQAEMFEHLSGK LQQFMENKSRMLASGNQPDQDITHFFQQIQELNLEMEDQQENLDTLEHLVTELSSCGFALDLCQHQDRVQNLRKDFTELQKTVKEREKDA SSCQEQLDEFRKLVRTFQKWLKETEGSIPPTETSMSAKELEKQIEHLKSLLDDWASKGTLVEEINCKGTSLENLIMEITAPDSQGKTGSI LPSVGSSVGSVNGYHTCKDLTEIQCDMSDVNLKYEKLGGVLHERQESLQAILNRMEEVHKEANSVLQWLESKEEVLKSMDAMSSPTKTET VKAQAESNKAFLAELEQNSPKIQKVKEALAGLLVTYPNSQEAENWKKIQEELNSRWERATEVTVARQRQLEESASHLACFQAAESQLRPW LMEKELMMGVLGPLSIDPNMLNAQKQQVQFMLKEFEARRQQHEQLNEAAQGILTGPGDVSLSTSQVQKELQSINQKWVELTDKLNSRSSQ IDQAIVKSTQYQELLQDLSEKVRAVGQRLSVQSAISTQPEAVKQQLEETSEIRSDLEQLDHEVKEAQTLCDELSVLIGEQYLKDELKKRL ETVALPLQGLEDLAADRINRLQAALASTQQFQQMFDELRTWLDDKQSQQAKNCPISAKLERLQSQLQENEEFQKSLNQHSGSYEVIVAEG ESLLLSVPPGEEKRTLQNQLVELKNHWEELSKKTADRQSRLKDCMQKAQKYQWHVEDLVPWIEDCKAKMSELRVTLDPVQLESSLLRSKA MLNEVEKRRSLLEILNSAADILINSSEADEDGIRDEKAGINQNMDAVTEELQAKTGSLEEMTQRLREFQESFKNIEKKVEGAKHQLEIFD ALGSQACSNKNLEKLRAQQEVLQALEPQVDYLRNFTQGLVEDAPDGSDASQLLHQAEVAQQEFLEVKQRVNSGCVMMENKLEGIGQFHCR VREMFSQLADLDDELDGMGAIGRDTDSLQSQIEDVRLFLNKIHVLKLDIEASEAECRHMLEEEGTLDLLGLKRELEALNKQCGKLTERGK ARQEQLELTLGRVEDFYRKLKGLNDATTAAEEAEALQWVVGTEVEIINQQLADFKMFQKEQVDPLQMKLQQVNGLGQGLIQSAGKDCDVQ GLEHDMEEINARWNTLNKKVAQRIAQLQEALLHCGKFQDALEPLLSWLADTEELIANQKPPSAEYKVVKAQIQEQKLLQRLLDDRKATVD MLQAEGGRIAQSAELADREKITGQLESLESRWTELLSKAAARQKQLEDILVLAKQFHETAEPISDFLSVTEKKLANSEPVGTQTAKIQQQ IIRHKALEEDIENHATDVHQAVKIGQSLSSLTSPAEQGVLSEKIDSLQARYSEIQDRCCRKAALLDQALSNARLFGEDEVEVLNWLAEVE DKLSSVFVKDFKQDVLHRQHADHLALNEEIVNRKKNVDQAIKNGQALLKQTTGEEVLLIQEKLDGIKTRYADITVTSSKALRTLEQARQL ATKFQSTYEELTGWLREVEEELATSGGQSPTGEQIPQFQQRQKELKKEVMEHRLVLDTVNEVSRALLELVPWRAREGLDKLVSDANEQYK LVSDTIGQRVDEIDAAIQRSQQYEQAADAELAWVAETKRKLMALGPIRLEQDQTTAQLQVQKAFSIDIIRHKDSMDELFSHRSEIFGTCG EEQKTVLQEKTESLIQQYEAISLLNSERYARLERAQVLVNQFWETYEELSPWIEETRALIAQLPSPAIDHEQLRQQQEEMRQLRESIAEH KPHIDKLLKIGPQLKELNPEEGEMVEEKYQKAENMYAQIKEEVRQRALALDEAVSQSTQITEFHDKIEPMLETLENLSSRLRMPPLIPAE VDKIRECISDNKSATVELEKLQPSFEALKRRGEELIGRSQGADKDLAAKEIQDKLDQMVFFWEDIKARAEEREIKFLDVLELAEKFWYDM AALLTTIKDTQDIVHDLESPGIDPSIIKQQVEAAETIKEETDGLHEELEFIRILGADLIFACGETEKPEVRKSIDEMNNAWENLNKTWKE RLEKLEDAMQAAVQYQDTLQAMFDWLDNTVIKLCTMPPVGTDLNTVKDQLNEMKEFKVEVYQQQIEMEKLNHQGELMLKKATDETDRDII REPLTELKHLWENLGEKIAHRQHKLEGALLALGQFQHALEELMSWLTHTEELLDAQRPISGDPKVIEVELAKHHVLKNDVLAHQATVETV NKAGNELLESSAGDDASSLRSRLEAMNQCWESVLQKTEEREQQLQSTLQQAQGFHSEIEDFLLELTRMESQLSASKPTGGLPETAREQLD THMELYSQLKAKEETYNQLLDKGRLMLLSRDDSGSGSKTEQSVALLEQKWHVVSSKMEERKSKLEEALNLATEFQNSLQEFINWLTLAEQ SLNIASPPSLILNTVLSQIEEHKVFANEVNAHRDQIIELDQTGNQLKFLSQKQDVVLIKNLLVSVQSRWEKVVQRSIERGRSLDDARKRA KQFHEAWKKLIDWLEDAESHLDSELEISNDPDKIKLQLSKHKEFQKTLGGKQPVYDTTIRTGRALKEKTLLPEDSQKLDNFLGEVRDKWD TVCGKSVERQHKLEEALLFSGQFMDALQALVDWLYKVEPQLAEDQPVHGDLDLVMNLMDAHKVFQKELGKRTGTVQVLKRSGRELIENSR DDTTWVKGQLQELSTRWDTVCKLSVSKQSRLEQALKQAEVFRDTVHMLLEWLSEAEQTLRFRGALPDDTEALQSLIDTHKEFMKKVEEKR VDVNSAVAMGEVILAVCHPDCITTIKHWITIIRARFEEVLTWAKQHQQRLETALSELVANAELLEELLAWIQWAETTLIQRDQEPIPQNI DRVKALIAEHQTFMEEMTRKQPDVDRVTKTYKRKNIEPTHAPFIEKSRSGGRKSLSQPTPPPMPILSQSEAKNPRINQLSARWQQVWLLA LERQRKLNDALDRLEELKEFANFDFDVWRKKYMRWMNHKKSRVMDFFRRIDKDQDGKITRQEFIDGILASKFPTTKLEMTAVADIFDRDG DGYIDYYEFVAALHPNKDAYRPTTDADKIEDEVTRQVAQCKCAKRFQVEQIGENKYRFGDSQQLRLVRILRSTVMVRVGGGWMALDEFLV KNDPCRARGRTNIELREKFILPEGASQGMTPFRSRGRRSKPSSRAASPTRSSSSASQSNHSCTSMPSSPATPASGTKVIPSSGSKLKRPT PTFHSSRTSLAGDTSNSSSPASTGAKTNRADPKKSASRPGSRAGSRAGSRASSRRGSDASDFDLLETQSACSDTSESSAAGGQGNSRRGL -------------------------------------------------------------- >59734_59734_3_NOTCH2-MACF1_NOTCH2_chr1_120572529_ENST00000256646_MACF1_chr1_39775242_ENST00000372915_length(amino acids)=6573AA_BP=120 MRRRPRSGGLGARGVEAFAPGLRSVAPGPEPLKQEEGRREWGSSIGTPSPCGSAQAAAAAAEEEATEKMPALRPALLWALLALWLCCAAP AHALQCRDGYEPCVNEGMCVTYHNGTGYCKVEQSYQKVMALWHQLHVNTKSLISWNYLRKDLDLVQTWNLEKLRSSAPGECHQIMKNLQA HYEDFLQDSRDSVLFSVADRLRLEEEVEACKARFQHLMKSMENEDKEETVAKMYISELKNIRLRLEEYEQRVVKRIQSLASSRTDRDAWQ DNALRIAEQEHTQEDLQQLRSDLDAVSMKCDSFLHQSPSSSSVPTLRSELNLLVEKMDHVYGLSTVYLNKLKTVDVIVRSIQDAELLVKG YEIKLSQEEVVLADLSALEAHWSTLRHWLSDVKDKNSVFSVLDEEIAKAKVVAEQMSRLTPERNLDLERYQEKGSQLQERWHRVIAQLEI RQSELESIQEVLGDYRACHGTLIKWIEETTAQQEMMKPGQAEDSRVLSEQLSQQTALFAEIERNQTKLDQCQKFSQQYSTIVKDYELQLM TYKAFVESQQKSPGKRRRMLSSSDAITQEFMDLRTRYTALVTLTTQHVKYISDALRRLEEEEKVVEEEKQEHVEKVKELLGWVSTLARNT QGKATSSETKESTDIEKAILEQQVLSEELTTKKEQVSEAIKTSQIFLAKHGHKLSEKEKKQISEQLNALNKAYHDLCDGSANQLQQLQSQ LAHQTEQKECRAVAGVIDLGTVEIFPIFKAMQKGLLDQDTGLVLLESQVIMSGLIAPETGENLSLEEGIARNLINPQMYQQLRELQDALA LISRLTESRGPLSVVEAIEKRIISETVGLKILEAHLATGGFSLSPSENCINLEEAFHQGLISAWLHSVLESYLRTSKNLIDPNTAEKIGL LDLMQRCIVHQESGFKLLPVKQLAGGMVSLKSGRKVSIFRAVQEGLIDRQVTVRLLEAQLFAGGIVDPRTGHRLTVEEAVRHNLIDQDMA CAILIRQLQTGGIIDTVTGQRLTIDEAVSNDLVAAKIALVILESLWSFMGLLWPESGEILPITDALEQGIVSTELAHKILSNRQHIKALF LPATTEILSWKKAIESGILDRDLANNLKSICIPDVMPHMQLADSAEQNINPGAAVLPCSKSHPKATASQSENLLFQLMTHSYINVQNGQR LLLLDKELMETLTSRDEYQTSPPKVVEIGHQRQKTPEGLQESANVKISGTFSSGWTVRLPEFQFSSQNKEYPDREDCTTEKGKKTTVETE DSSVENPEQDLFVEQKERNPNIDALKVINKVKLEVQRQLIGTQREDQTAVSVRENASRGHLLTIPPAEAEGVPLVVDKDVFSVETPKKEH QPLRNTSFTCQNEQAHTLETEYIHDETGGSHIKPQSKKLQVQVKKTLGIKLELKSETDGNVHPLDKKEMLKKTFLAKDDHKESQEAQNIA GGSMMMSEKTDEEDSGREIFLSCSHPLELLEEATLNVLSAQLLDGGIFHEQTGQKLLLNEAISRGIVPSHTAVKLMEKLNMFQGFFDSQT CESLTTEEVINEGLMDEKLLHNVLMADKAISGVLDPRTQTLCSVKDAVTVGLLDKETATRILERQVVTGGIIDLKRGKKVSVTLASTLGL VDVADQPELINLEKASKGRDAEKTVRERLISLQMETTGLIDPDSKAPLTVVQSIDRGLLEREEAVRLLTKQVVDGGIIHHISGMRLSVDN AFRHGLIGEDLAEKLKRVENLNIHQIFNPETKENISLPKAIKLDLITSDLKREIQEVQAFTGNFVDLISGQRLTLAEAKKEGLLTNEAVL SPGMMHGIVDPENCRIVPYSELVKKCKIDIESGQRYLEVIPFSDIKDGVSDKVLTLSQAIQLGKVDFASTLKVLEAQANTGGIIDTATGK RLTLASALEEKLVDENMVRIIASHQVLNGGIVDIFSDQRVTLVEAIEKRLISPELANMIQIDSSEFSDHRAQIEKQEGIEVCALQNEFLG KDMLIACNQTAEMSCNKVEESERLFQVENQSAQEKVKVRVSDGEQAKKSREISLKEFGCKDQRKPRMSSDAKEFISIINPHNLKGKSLGQ VSLTHPYSECDFKLKEVARNNMGNDTNEEQEKAVTKIEIISHMKQSTSCLDSEEIRENQGEVILEVQETYCETSGKLPSEQVLQQPMNAR VKSKREKREVIVEESIRTCKPAFLSEEKLYQETAIRDEHDSHIKSQPREMTSSEKGKEADTEMGFSITFKIEESSSQVVPQGISVKHLDA LTLFSSKQANEGKVNNLSLCLTLKPEENLSREIACGAQSEPFPCMTPRPEGLHYQESDGKAQVTGPSQISKTDKSFQGTTRQETNYQDSW VTSKTKETKHQISSSNECKEKSYQEVSFDPARGLKLEEITVSRPDSKEVRYLEFSDRKDLHHQGSKSDDKLCGTLKSEIATQELTGEKFL EMANPNVAGLEAGSIEDIVTQRGSRVLGSFLPEKLFKGVSQKENTGQQNAIISPTVLETSEEKTVSLTVCSAVKTEKTPQEKLRESPGSE QTPFMTAPEGKGNGGVNPEPFRATQNVFTRQLCLEHDEKLVSYLSLLRNIEMRTKQIQPLELNLAELQDLLCQAKVLERELKDLTTLVSQ ELECVNQIIISQPQEVPAQLLKALEKDAKNLQKSLSSVSDTWNSRLLHFQNAVEIEKTKVLNQHTQLEGRLQDLRAWVGNKNLILNSKGS NSEIDVDSLNLCLQQYEDLKQPMAERKAQLDALAFDIQFFISEHAQDLSPQQNRQMLRLLNELQRSFQDILEQTAAQVDALQGHLQQMEQ EALVKTLQKQQNTCHQQLEDLCSWVGQAERALAGHQGRTTQQDLSALQKNQSDLKDLQDDIQNRATSFATVVKDIEGFMEENQTKLSPRE LTALREKLHQAKEQYEALQEETRVAQKELEEAVTSALQQETEKSKAAKELAENKKKIDALLDWVTSVGSSGGQLLTNLPGMEQLSGASLE KGALDTTDGYMGVNQAPEKLDKQCEMMKARHQELLSQQQNFILATQSAQAFLDQHGHNLTPEEQQMLQQKLGELKEQYSTSLAQSEAELK QVQTLQDELQKFLQDHKEFESWLERSEKELENMHKGGSSPETLPSLLKRQGSFSEDVISHKGDLRFVTISGQKVLDMENSFKEGKEPSEI GNLVKDKLKDATERYTALHSKCTRLGSHLNMLLGQYHQFQNSADSLQAWMQACEANVEKLLSDTVASDPGVLQEQLATTKQLQEELAEHQ VPVEKLQKVARDIMEIEGEPAPDHRHVQETTDSILSHFQSLSYSLAERSSLLQKAIAQSQSVQESLESLLQSIGEVEQNLEGKQVSSLSS GVIQEALATNMKLKQDIARQKSSLEATREMVTRFMETADSTTAAVLQGKLAEVSQRFEQLCLQQQEKESSLKKLLPQAEMFEHLSGKLQQ FMENKSRMLASGNQPDQDITHFFQQIQELNLEMEDQQENLDTLEHLVTELSSCGFALDLCQHQDRVQNLRKDFTELQKTVKEREKDASSC QEQLDEFRKLVRTFQKWLKETEGSIPPTETSMSAKELEKQIEHLKSLLDDWASKGTLVEEINCKGTSLENLIMEITAPDSQGKTGSILPS VGSSVGSVNGYHTCKDLTEIQCDMSDVNLKYEKLGGVLHERQESLQAILNRMEEVHKEANSVLQWLESKEEVLKSMDAMSSPTKTETVKA QAESNKAFLAELEQNSPKIQKVKEALAGLLVTYPNSQEAENWKKIQEELNSRWERATEVTVARQRQLEESASHLACFQAAESQLRPWLME KELMMGVLGPLSIDPNMLNAQKQQVQFMLKEFEARRQQHEQLNEAAQGILTGPGDVSLSTSQVQKELQSINQKWVELTDKLNSRSSQIDQ AIVKSTQYQELLQDLSEKVRAVGQRLSVQSAISTQPEAVKQQLEETSEIRSDLEQLDHEVKEAQTLCDELSVLIGEQYLKDELKKRLETV ALPLQGLEDLAADRINRLQAALASTQQFQQMFDELRTWLDDKQSQQAKNCPISAKLERLQSQLQENEEFQKSLNQHSGSYEVIVAEGESL LLSVPPGEEKRTLQNQLVELKNHWEELSKKTADRQSRLKDCMQKAQKYQWHVEDLVPWIEDCKAKMSELRVTLDPVQLESSLLRSKAMLN EVEKRRSLLEILNSAADILINSSEADEDGIRDEKAGINQNMDAVTEELQAKTGSLEEMTQRLREFQESFKNIEKKVEGAKHQLEIFDALG SQACSNKNLEKLRAQQEVLQALEPQVDYLRNFTQGLVEDAPDGSDASQLLHQAEVAQQEFLEVKQRVNSGCVMMENKLEGIGQFHCRVRE MFSQLADLDDELDGMGAIGRDTDSLQSQIEDVRLFLNKIHVLKLDIEASEAECRHMLEEEGTLDLLGLKRELEALNKQCGKLTERGKARQ EQLELTLGRVEDFYRKLKGLNDATTAAEEAEALQWVVGTEVEIINQQLADFKMFQKEQVDPLQMKLQQVNGLGQGLIQSAGKDCDVQGLE HDMEEINARWNTLNKKVAQRIAQLQEALLHCGKFQDALEPLLSWLADTEELIANQKPPSAEYKVVKAQIQEQKLLQRLLDDRKATVDMLQ AEGGRIAQSAELADREKITGQLESLESRWTELLSKAAARQKQLEDILVLAKQFHETAEPISDFLSVTEKKLANSEPVGTQTAKIQQQIIR HKALNEEIVNRKKNVDQAIKNGQALLKQTTGEEVLLIQEKLDGIKTRYADITVTSSKALRTLEQARQLATKFQSTYEELTGWLREVEEEL ATSGGQSPTGEQIPQFQQRQKELKKEVMEHRLVLDTVNEVSRALLELVPWRAREGLDKLVSDANEQYKLVSDTIGQRVDEIDAAIQRSQQ YEQAADAELAWVAETKRKLMALGPIRLEQDQTTAQLQVQKAFSIDIIRHKDSMDELFSHRSEIFGTCGEEQKTVLQEKTESLIQQYEAIS LLNSERYARLERAQVLVNQFWETYEELSPWIEETRALIAQLPSPAIDHEQLRQQQEEMRQLRESIAEHKPHIDKLLKIGPQLKELNPEEG EMVEEKYQKAENMYAQIKEEVRQRALALDEAVSQSTQITEFHDKIEPMLETLENLSSRLRMPPLIPAEVDKIRECISDNKSATVELEKLQ PSFEALKRRGEELIGRSQGADKDLAAKEIQDKLDQMVFFWEDIKARAEEREIKFLDVLELAEKFWYDMAALLTTIKDTQDIVHDLESPGI DPSIIKQQVEAAETIKEETDGLHEELEFIRILGADLIFACGETEKPEVRKSIDEMNNAWENLNKTWKERLEKLEDAMQAAVQYQDTLQAM FDWLDNTVIKLCTMPPVGTDLNTVKDQLNEMKEFKVEVYQQQIEMEKLNHQGELMLKKATDETDRDIIREPLTELKHLWENLGEKIAHRQ HKLEGALLALGQFQHALEELMSWLTHTEELLDAQRPISGDPKVIEVELAKHHVLKNDVLAHQATVETVNKAGNELLESSAGDDASSLRSR LEAMNQCWESVLQKTEEREQQLQSTLQQAQGFHSEIEDFLLELTRMESQLSASKPTGGLPETAREQLDTHMELYSQLKAKEETYNQLLDK GRLMLLSRDDSGSGSKTEQSVALLEQKWHVVSSKMEERKSKLEEALNLATEFQNSLQEFINWLTLAEQSLNIASPPSLILNTVLSQIEEH KVFANEVNAHRDQIIELDQTGNQLKFLSQKQDVVLIKNLLVSVQSRWEKVVQRSIERGRSLDDARKRAKQFHEAWKKLIDWLEDAESHLD SELEISNDPDKIKLQLSKHKEFQKTLGGKQPVYDTTIRTGRALKEKTLLPEDSQKLDNFLGEVRDKWDTVCGKSVERQHKLEEALLFSGQ FMDALQALVDWLYKVEPQLAEDQPVHGDLDLVMNLMDAHKVFQKELGKRTGTVQVLKRSGRELIENSRDDTTWVKGQLQELSTRWDTVCK LSVSKQSRLEQALKQAEVFRDTVHMLLEWLSEAEQTLRFRGALPDDTEALQSLIDTHKEFMKKVEEKRVDVNSAVAMGEVILAVCHPDCI TTIKHWITIIRARFEEVLTWAKQHQQRLETALSELVANAELLEELLAWIQWAETTLIQRDQEPIPQNIDRVKALIAEHQTFMEEMTRKQP DVDRVTKTYKRKNIEPTHAPFIEKSRSGGRKSLSQPTPPPMPILSQSEAKNPRINQLSARWQQVWLLALERQRKLNDALDRLEELKEFAN FDFDVWRKKYMRWMNHKKSRVMDFFRRIDKDQDGKITRQEFIDGILASKFPTTKLEMTAVADIFDRDGDGYIDYYEFVAALHPNKDAYRP TTDADKIEDEVTRQVAQCKCAKRFQVEQIGENKYRFGDSQQLRLVRILRSTVMVRVGGGWMALDEFLVKNDPCRARGRTNIELREKFILP EGASQGMTPFRSRGRRSKPSSRAASPTRSSSSASQSNHSCTSMPSSPATPASGTKVIPSSGSKLKRPTPTFHSSRTSLAGDTSNSSSPAS TGAKTNRADPKKSASRPGSRAGSRAGSRASSRRGSDASDFDLLETQSACSDTSESSAAGGQGNSRRGLNKPSKIPTMSKKTTTASPRTPG -------------------------------------------------------------- >59734_59734_4_NOTCH2-MACF1_NOTCH2_chr1_120572529_ENST00000256646_MACF1_chr1_39775242_ENST00000539005_length(amino acids)=4485AA_BP=120 MRRRPRSGGLGARGVEAFAPGLRSVAPGPEPLKQEEGRREWGSSIGTPSPCGSAQAAAAAAEEEATEKMPALRPALLWALLALWLCCAAP AHALQCRDGYEPCVNEGMCVTYHNGTGYCKVEQSYQKVMALWHQLHVNTKSLISWNYLRKDLDLVQTWNLEKLRSSAPGECHQIMKNLQA HYEDFLQDSRDSVLFSVADRLRLEEEVEACKARFQHLMKSMENEDKEETVAKMYISELKNIRLRLEEYEQRVVKRIQSLASSRTDRDAWQ DNALRIAEQEHTQEDLQQLRSDLDAVSMKCDSFLHQSPSSSSVPTLRSELNLLVEKMDHVYGLSTVYLNKLKTVDVIVRSIQDAELLVKG YEIKLSQEEVVLADLSALEAHWSTLRHWLSDVKDKNSVFSVLDEEIAKAKVVAEQMSRLTPERNLDLERYQEKGSQLQERWHRVIAQLEI RQSELESIQEVLGDYRACHGTLIKWIEETTAQQEMMKPGQAEDSRVLSEQLSQQTALFAEIERNQTKLDQCQKFSQQYSTIVKDYELQLM TYKAFVESQQKSPGKRRRMLSSSDAITQEFMDLRTRYTALVTLTTQHVKYISDALRRLEEEEKVVEEEKQEHVEKVKELLGWVSTLARNT QGKATSSETKESTDIEKAILEQQVLSEELTTKKEQVSEAIKTSQIFLAKHGHKLSEKEKKQISEQLNALNKAYHDLCDGSANQLQQLQSQ LAHQTEQKTLQKQQNTCHQQLEDLCSWVGQAERALAGHQGRTTQQDLSALQKNQSDLKDLQDDIQNRATSFATVVKDIEGFMEENQTKLS PRELTALREKLHQAKEQYEALQEETRVAQKELEEAVTSALQQETEKSKAAKELAENKKKIDALLDWVTSVGSSGGQLLTNLPGMEQLSGA SLEKGALDTTDGYMGVNQAPEKLDKQCEMMKARHQELLSQQQNFILATQSAQAFLDQHGHNLTPEEQQMLQQKLGELKEQYSTSLAQSEA ELKQVQTLQDELQKFLQDHKEFESWLERSEKELENMHKGGSSPETLPSLLKRQGSFSEDVISHKGDLRFVTISGQKVLDMENSFKEGKEP SEIGNLVKDKLKDATERYTALHSKCTRLGSHLNMLLGQYHQFQNSADSLQAWMQACEANVEKLLSDTVASDPGVLQEQLATTKQLQEELA EHQVPVEKLQKVARDIMEIEGEPAPDHRHVQETTDSILSHFQSLSYSLAERSSLLQKAIAQSQSVQESLESLLQSIGEVEQNLEGKQVSS LSSGVIQEALATNMKLKQDIARQKSSLEATREMVTRFMETADSTTAAVLQGKLAEVSQRFEQLCLQQQEKESSLKKLLPQAEMFEHLSGK LQQFMENKSRMLASGNQPDQDITHFFQQIQELNLEMEDQQENLDTLEHLVTELSSCGFALDLCQHQDRVQNLRKDFTELQKTVKEREKDA SSCQEQLDEFRKLVRTFQKWLKETEGSIPPTETSMSAKELEKQIEHLKSLLDDWASKGTLVEEINCKGTSLENLIMEITAPDSQGKTDLT EIQCDMSDVNLKYEKLGGVLHERQESLQAILNRMEEVHKEANSVLQWLESKEEVLKSMDAMSSPTKTETVKAQAESNKAFLAELEQNSPK IQKVKEALAGLLVTYPNSQEAENWKKIQEELNSRWERATEVTVARQRQLEESASHLACFQAAESQLRPWLMEKELMMGVLGPLSIDPNML NAQKQQVQFMLKEFEARRQQHEQLNEAAQGILTGPGDVSLSTSQVQKELQSINQKWVELTDKLNSRSSQIDQAIVKSTQYQELLQDLSEK VRAVGQRLSVQSAISTQPEAVKQQLEETSEIRSDLEQLDHEVKEAQTLCDELSVLIGEQYLKDELKKRLETVALPLQGLEDLAADRINRL QAALASTQQFQQMFDELRTWLDDKQSQQAKNCPISAKLERLQSQLQENEEFQKSLNQHSGSYEVIVAEGESLLLSVPPGEEKRTLQNQLV ELKNHWEELSKKTADRQSRLKDCMQKAQKYQWHVEDLVPWIEDCKAKMSELRVTLDPVQLESSLLRSKAMLNEVEKRRSLLEILNSAADI LINSSEADEDGIRDEKAGINQNMDAVTEELQAKTGSLEEMTQRLREFQESFKNIEKKVEGAKHQLEIFDALGSQACSNKNLEKLRAQQEV LQALEPQVDYLRNFTQGLVEDAPDGSDASQLLHQAEVAQQEFLEVKQRVNSGCVMMENKLEGIGQFHCRVREMFSQLADLDDELDGMGAI GRDTDSLQSQIEDVRLFLNKIHVLKLDIEASEAECRHMLEEEGTLDLLGLKRELEALNKQCGKLTERGKARQEQLELTLGRVEDFYRKLK GLNDATTAAEEAEALQWVVGTEVEIINQQLADFKMFQKEQVDPLQMKLQQVNGLGQGLIQSAGKDCDVQGLEHDMEEINARWNTLNKKVA QRIAQLQEALLHCGKFQDALEPLLSWLADTEELIANQKPPSAEYKVVKAQIQEQKLLQRLLDDRKATVDMLQAEGGRIAQSAELADREKI TGQLESLESRWTELLSKAAARQKQLEDILVLAKQFHETAEPISDFLSVTEKKLANSEPVGTQTAKIQQQIIRHKALNEEIVNRKKNVDQA IKNGQALLKQTTGEEVLLIQEKLDGIKTRYADITVTSSKALRTLEQARQLATKFQSTYEELTGWLREVEEELATSGGQSPTGEQIPQFQQ RQKELKKEVMEHRLVLDTVNEVSRALLELVPWRAREGLDKLVSDANEQYKLVSDTIGQRVDEIDAAIQRSQQYEQAADAELAWVAETKRK LMALGPIRLEQDQTTAQLQVQKAFSIDIIRHKDSMDELFSHRSEIFGTCGEEQKTVLQEKTESLIQQYEAISLLNSERYARLERAQVLVN QFWETYEELSPWIEETRALIAQLPSPAIDHEQLRQQQEEMRQLRESIAEHKPHIDKLLKIGPQLKELNPEEGEMVEEKYQKAENMYAQIK EEVRQRALALDEAVSQSTQVSQFHDKIEPMLETLENLSSRLRMPPLIPAEVDKIRECISDNKSATVELEKLQPSFEALKRRGEELIGRSQ GADKDLAAKEIQDKLDQMVFFWEDIKARAEEREIKFLDVLELAEKFWYDMAALLTTIKDTQDIVHDLESPGIDPSIIKQQVEAAETIKEE TDGLHEELEFIRILGADLIFACGETEKPEVRKSIDEMNNAWENLNKTWKERLEKLEDAMQAAVQYQDTLQAMFDWLDNTVIKLCTMPPVG TDLNTVKDQLNEMKEFKVEVYQQQIEMEKLNHQGELMLKKATDETDRDIIREPLTELKHLWENLGEKIAHRQHKLEGALLALGQFQHALE ELMSWLTHTEELLDAQRPISGDPKVIEVELAKHHVLKNDVLAHQATVETVNKAGNELLESSAGDDASSLRSRLEAMNQCWESVLQKTEER EQQLQSTLQQAQGFHSEIEDFLLELTRMESQLSASKPTGGLPETAREQLDTHMELYSQLKAKEETYNQLLDKGRLMLLSRDDSGSGSKTE QSVALLEQKWHVVSSKMEERKSKLEEALNLATEFQNSLQEFINWLTLAEQSLNIASPPSLILNTVLSQIEEHKVFANEVNAHRDQIIELD QTGNQLKFLSQKQDVVLIKNLLVSVQSRWEKVVQRSIERGRSLDDARKRAKQFHEAWKKLIDWLEDAESHLDSELEISNDPDKIKLQLSK HKEFQKTLGGKQPVYDTTIRTGRALKEKTLLPEDSQKLDNFLGEVRDKWDTVCGKSVERQHKLEEALLFSGQFMDALQALVDWLYKVEPQ LAEDQPVHGDLDLVMNLMDAHKVFQKELGKRTGTVQVLKRSGRELIENSRDDTTWVKGQLQELSTRWDTVCKLSVSKQSRLEQALKQAEV FRDTVHMLLEWLSEAEQTLRFRGALPDDTEALQSLIDTHKEFMKKVEEKRVDVNSAVAMGEVILAVCHPDCITTIKHWITIIRARFEEVL TWAKQHQQRLETALSELVANAELLEELLAWIQWAETTLIQRDQEPIPQNIDRVKALIAEHQTFMEEMTRKQPDVDRVTKTYKRKNIEPTH APFIEKSRSGGRKSLSQPTPPPMPILSQSEAKNPRINQLSARWQQVWLLALERQRKLNDALDRLEELKEFANFDFDVWRKKYMRWMNHKK SRVMDFFRRIDKDQDGKITRQEFIDGILASKFPTTKLEMTAVADIFDRDGDGYIDYYEFVAALHPNKDAYRPTTDADKIEDEVTRQVAQC KCAKRFQVEQIGENKYRFGDSQQLRLVRILRSTVMVRVGGGWMALDEFLVKNDPCRARGRTNIELREKFILPEGASQGMTPFRSRGRRSK PSSRAASPTRSSSSASQSNHSCTSMPSSPATPASGTKVIPSSGSKLKRPTPTFHSSRTSLAGDTSNSSSPASTGAKTNRADPKKSASRPG -------------------------------------------------------------- >59734_59734_5_NOTCH2-MACF1_NOTCH2_chr1_120572529_ENST00000256646_MACF1_chr1_39775242_ENST00000545844_length(amino acids)=4615AA_BP=120 MRRRPRSGGLGARGVEAFAPGLRSVAPGPEPLKQEEGRREWGSSIGTPSPCGSAQAAAAAAEEEATEKMPALRPALLWALLALWLCCAAP AHALQCRDGYEPCVNEGMCVTYHNGTGYCKVEQSYQKVMALWHQLHVNTKSLISWNYLRKDLDLVQTWNLEKLRSSAPGECHQIMKNLQA HYEDFLQDSRDSVLFSVADRLRLEEEVEACKARFQHLMKSMENEDKEETVAKMYISELKNIRLRLEEYEQRVVKRIQSLASSRTDRDAWQ DNALRIAEQEHTQEDLQQLRSDLDAVSMKCDSFLHQSPSSSSVPTLRSELNLLVEKMDHVYGLSTVYLNKLKTVDVIVRSIQDAELLVKG YEIKLSQEEVVLADLSALEAHWSTLRHWLSDVKDKNSVFSVLDEEIAKAKVVAEQMSRLTPERNLDLERYQEKGSQLQERWHRVIAQLEI RQSELESIQEVLGDYRACHGTLIKWIEETTAQQEMMKPGQAEDSRVLSEQLSQQTALFAEIERNQTKLDQCQKFSQQYSTIVKDYELQLM TYKAFVESQQKSPGKRRRMLSSSDAITQEFMDLRTRYTALVTLTTQHVKYISDALRRLEEEEKVVEEEKQEHVEKVKELLGWVSTLARNT QGKATSSETKESTDIEKAILEQQVLSEELTTKKEQVSEAIKTSQIFLAKHGHKLSEKEKKQISEQLNALNKAYHDLCDGSANQLQQLQSQ LAHQTEQKTLQKQQNTCHQQLEDLCSWVGQAERALAGHQGRTTQQDLSALQKNQSDLKDLQDDIQNRATSFATVVKDIEGFMEENQTKLS PRELTALREKLHQAKEQYEALQEETRVAQKELEEAVTSALQQETEKSKAAKELAENKKKIDALLDWVTSVGSSGGQLLTNLPGMEQLSGA SLEKGALDTTDGYMGVNQAPEKLDKQCEMMKARHQELLSQQQNFILATQSAQAFLDQHGHNLTPEEQQMLQQKLGELKEQYSTSLAQSEA ELKQVQTLQDELQKFLQDHKEFESWLERSEKELENMHKGGSSPETLPSLLKRQGSFSEDVISHKGDLRFVTISGQKVLDMENSFKEGKEP SEIGNLVKDKLKDATERYTALHSKCTRLGSHLNMLLGQYHQFQNSADSLQAWMQACEANVEKLLSDTVASDPGVLQEQLATTKQLQEELA EHQVPVEKLQKVARDIMEIEGEPAPDHRHVQETTDSILSHFQSLSYSLAERSSLLQKAIAQSQSVQESLESLLQSIGEVEQNLEGKQVSS LSSGVIQEALATNMKLKQDIARQKSSLEATREMVTRFMETADSTTAAVLQGKLAEVSQRFEQLCLQQQEKESSLKKLLPQAEMFEHLSGK LQQFMENKSRMLASGNQPDQDITHFFQQIQELNLEMEDQQENLDTLEHLVTELSSCGFALDLCQHQDRVQNLRKDFTELQKTVKEREKDA SSCQEQLDEFRKLVRTFQKWLKETEGSIPPTETSMSAKELEKQIEHLKSLLDDWASKGTLVEEINCKGTSLENLIMEITAPDSQGKTGSI LPSVGSSVGSVNGYHTCKDLTEIQCDMSDVNLKYEKLGGVLHERQESLQAILNRMEEVHKEANSVLQWLESKEEVLKSMDAMSSPTKTET VKAQAESNKAFLAELEQNSPKIQKVKEALAGLLVTYPNSQEAENWKKIQEELNSRWERATEVTVARQRQLEESASHLACFQAAESQLRPW LMEKELMMGVLGPLSIDPNMLNAQKQQVQFMLKEFEARRQQHEQLNEAAQGILTGPGDVSLSTSQVQKELQSINQKWVELTDKLNSRSSQ IDQAIVKSTQYQELLQDLSEKVRAVGQRLSVQSAISTQPEAVKQQLEETSEIRSDLEQLDHEVKEAQTLCDELSVLIGEQYLKDELKKRL ETVALPLQGLEDLAADRINRLQAALASTQQFQQMFDELRTWLDDKQSQQAKNCPISAKLERLQSQLQENEEFQKSLNQHSGSYEVIVAEG ESLLLSVPPGEEKRTLQNQLVELKNHWEELSKKTADRQSRLKDCMQKAQKYQWHVEDLVPWIEDCKAKMSELRVTLDPVQLESSLLRSKA MLNEVEKRRSLLEILNSAADILINSSEADEDGIRDEKAGINQNMDAVTEELQAKTGSLEEMTQRLREFQESFKNIEKKVEGAKHQLEIFD ALGSQACSNKNLEKLRAQQEVLQALEPQVDYLRNFTQGLVEDAPDGSDASQLLHQAEVAQQEFLEVKQRVNSGCVMMENKLEGIGQFHCR VREMFSQLADLDDELDGMGAIGRDTDSLQSQIEDVRLFLNKIHVLKLDIEASEAECRHMLEEEGTLDLLGLKRELEALNKQCGKLTERGK ARQEQLELTLGRVEDFYRKLKGLNDATTAAEEAEALQWVVGTEVEIINQQLADFKMFQKEQVDPLQMKLQQVNGLGQGLIQSAGKDCDVQ GLEHDMEEINARWNTLNKKVAQRIAQLQEALLHCGKFQDALEPLLSWLADTEELIANQKPPSAEYKVVKAQIQEQKLLQRLLDDRKATVD MLQAEGGRIAQSAELADREKITGQLESLESRWTELLSKAAARQKQLEDILVLAKQFHETAEPISDFLSVTEKKLANSEPVGTQTAKIQQQ IIRHKALEEDIENHATDVHQAVKIGQSLSSLTSPAEQGVLSEKIDSLQARYSEIQDRCCRKAALLDQALSNARLFGEDEVEVLNWLAEVE DKLSSVFVKDFKQDVLHRQHADHLALNEEIVNRKKNVDQAIKNGQALLKQTTGEEVLLIQEKLDGIKTRYADITVTSSKALRTLEQARQL ATKFQSTYEELTGWLREVEEELATSGGQSPTGEQIPQFQQRQKELKKEVMEHRLVLDTVNEVSRALLELVPWRAREGLDKLVSDANEQYK LVSDTIGQRVDEIDAAIQRSQQYEQAADAELAWVAETKRKLMALGPIRLEQDQTTAQLQVQKAFSIDIIRHKDSMDELFSHRSEIFGTCG EEQKTVLQEKTESLIQQYEAISLLNSERYARLERAQVLVNQFWETYEELSPWIEETRALIAQLPSPAIDHEQLRQQQEEMRQLRESIAEH KPHIDKLLKIGPQLKELNPEEGEMVEEKYQKAENMYAQIKEEVRQRALALDEAVSQSTQITEFHDKIEPMLETLENLSSRLRMPPLIPAE VDKIRECISDNKSATVELEKLQPSFEALKRRGEELIGRSQGADKDLAAKEIQDKLDQMVFFWEDIKARAEEREIKFLDVLELAEKFWYDM AALLTTIKDTQDIVHDLESPGIDPSIIKQQVEAAETIKEETDGLHEELEFIRILGADLIFACGETEKPEVRKSIDEMNNAWENLNKTWKE RLEKLEDAMQAAVQYQDTLQAMFDWLDNTVIKLCTMPPVGTDLNTVKDQLNEMKEFKVEVYQQQIEMEKLNHQGELMLKKATDETDRDII REPLTELKHLWENLGEKIAHRQHKLEGALLALGQFQHALEELMSWLTHTEELLDAQRPISGDPKVIEVELAKHHVLKNDVLAHQATVETV NKAGNELLESSAGDDASSLRSRLEAMNQCWESVLQKTEEREQQLQSTLQQAQGFHSEIEDFLLELTRMESQLSASKPTGGLPETAREQLD THMELYSQLKAKEETYNQLLDKGRLMLLSRDDSGSGSKTEQSVALLEQKWHVVSSKMEERKSKLEEALNLATEFQNSLQEFINWLTLAEQ SLNIASPPSLILNTVLSQIEEHKVFANEVNAHRDQIIELDQTGNQLKFLSQKQDVVLIKNLLVSVQSRWEKVVQRSIERGRSLDDARKRA KQFHEAWKKLIDWLEDAESHLDSELEISNDPDKIKLQLSKHKEFQKTLGGKQPVYDTTIRTGRALKEKTLLPEDSQKLDNFLGEVRDKWD TVCGKSVERQHKLEEALLFSGQFMDALQALVDWLYKVEPQLAEDQPVHGDLDLVMNLMDAHKVFQKELGKRTGTVQVLKRSGRELIENSR DDTTWVKGQLQELSTRWDTVCKLSVSKQSRLEQALKQAEVFRDTVHMLLEWLSEAEQTLRFRGALPDDTEALQSLIDTHKEFMKKVEEKR VDVNSAVAMGEVILAVCHPDCITTIKHWITIIRARFEEVLTWAKQHQQRLETALSELVANAELLEELLAWIQWAETTLIQRDQEPIPQNI DRVKALIAEHQTFMEEMTRKQPDVDRVTKTYKRKNIEPTHAPFIEKSRSGGRKSLSQPTPPPMPILSQSEAKNPRINQLSARWQQVWLLA LERQRKLNDALDRLEELKEFANFDFDVWRKKYMRWMNHKKSRVMDFFRRIDKDQDGKITRQEFIDGILASKFPTTKLEMTAVADIFDRDG DGYIDYYEFVAALHPNKDAYRPTTDADKIEDEVTRQVAQCKCAKRFQVEQIGENKYRFGDSQQLRLVRILRSTVMVRVGGGWMALDEFLV KNDPCRARGRTNIELREKFILPEGASQGMTPFRSRGRRSKPSSRAASPTRSSSSASQSNHSCTSMPSSPATPASGTKVIPSSGSKLKRPT PTFHSSRTSLAGDTSNSSSPASTGAKTNRADPKKSASRPGSRAGSRAGSRASSRRGSDASDFDLLETQSACSDTSESSAAGGQGNSRRGL -------------------------------------------------------------- >59734_59734_6_NOTCH2-MACF1_NOTCH2_chr1_120572529_ENST00000256646_MACF1_chr1_39775242_ENST00000564288_length(amino acids)=6745AA_BP=120 MRRRPRSGGLGARGVEAFAPGLRSVAPGPEPLKQEEGRREWGSSIGTPSPCGSAQAAAAAAEEEATEKMPALRPALLWALLALWLCCAAP AHALQCRDGYEPCVNEGMCVTYHNGTGYCKVEQSYQKVMALWHQLHVNTKSLISWNYLRKDLDLVQTWNLEKLRSSAPGECHQIMKNLQA HYEDFLQDSRDSVLFSVADRLRLEEEVEACKARFQHLMKSMENEDKEETVAKMYISELKNIRLRLEEYEQRVVKRIQSLASSRTDRDAWQ DNALRIAEQEHTQEDLQQLRSDLDAVSMKCDSFLHQSPSSSSVPTLRSELNLLVEKMDHVYGLSTVYLNKLKTVDVIVRSIQDAELLVKG YEIKLSQEEVVLADLSALEAHWSTLRHWLSDVKDKNSVFSVLDEEIAKAKVVAEQMSRLTPERNLDLERYQEKGSQLQERWHRVIAQLEI RQSELESIQEVLGDYRACHGTLIKWIEETTAQQEMMKPGQAEDSRVLSEQLSQQTALFAEIERNQTKLDQCQKFSQQYSTIVKDYELQLM TYKAFVESQQKSPGKRRRMLSSSDAITQEFMDLRTRYTALVTLTTQHVKYISDALRRLEEEEKVVEEEKQEHVEKVKELLGWVSTLARNT QGKATSSETKESTDIEKAILEQQVLSEELTTKKEQVSEAIKTSQIFLAKHGHKLSEKEKKQISEQLNALNKAYHDLCDGSANQLQQLQSQ LAHQTEQKECRAVAGVIDLGTVEIFPIFKAMQKGLLDQDTGLVLLESQVIMSGLIAPETGENLSLEEGIARNLINPQMYQQLRELQDALA LISRLTESRGPLSVVEAIEKRIISETVGLKILEAHLATGGFSLSPSENCINLEEAFHQGLISAWLHSVLESYLRTSKNLIDPNTAEKIGL LDLMQRCIVHQESGFKLLPVKQLAGGMVSLKSGRKVSIFRAVQEGLIDRQVTVRLLEAQLFAGGIVDPRTGHRLTVEEAVRHNLIDQDMA CAILIRQLQTGGIIDTVTGQRLTIDEAVSNDLVAAKIALVILESLWSFMGLLWPESGEILPITDALEQGIVSTELAHKILSNRQHIKALF LPATTEILSWKKAIESGILDRDLANNLKSICIPDVMPHMQLADSAEQNINPGAAVLPCSKSHPKATASQSENLLFQLMTHSYINVQNGQR LLLLDKELMETLTSRDEYQTSPPKVVEIGHQRQKTPEGLQESANVKISGTFSSGWTVRLPEFQFSSQNKEYPDREDCTTEKGKKTTVETE DSSVENPEQDLFVEQKERNPNIDALKVINKVKLEVQRQLIGTQREDQTAVSVRENASRGHLLTIPPAEAEGVPLVVDKDVFSVETPKKEH QPLRNTSFTCQNEQAHTLETEYIHDETGGSHIKPQSKKLQVQVKKTLGIKLELKSETDGNVHPLDKKEMLKKTFLAKDDHKESQEAQNIA GGSMMMSEKTDEEDSGREIFLSCSHPLELLEEATLNVLSAQLLDGGIFHEQTGQKLLLNEAISRGIVPSHTAVKLMEKLNMFQGFFDSQT CESLTTEEVINEGLMDEKLLHNVLMADKAISGVLDPRTQTLCSVKDAVTVGLLDKETATRILERQVVTGGIIDLKRGKKVSVTLASTLGL VDVADQPELINLEKASKGRDAEKTVRERLISLQMETTGLIDPDSKAPLTVVQSIDRGLLEREEAVRLLTKQVVDGGIIHHISGMRLSVDN AFRHGLIGEDLAEKLKRVENLNIHQIFNPETKENISLPKAIKLDLITSDLKREIQEVQAFTGNFVDLISGQRLTLAEAKKEGLLTNEAVL SPGMMHGIVDPENCRIVPYSELVKKCKIDIESGQRYLEVIPFSDIKDGVSDKVLTLSQAIQLGKVDFASTLKVLEAQANTGGIIDTATGK RLTLASALEEKLVDENMVRIIASHQVLNGGIVDIFSDQRVTLVEAIEKRLISPELANMIQIDSSEFSDHRAQIEKQEGIEVCALQNEFLG KDMLIACNQTAEMSCNKVEESERLFQVENQSAQEKVKVRVSDGEQAKKSREISLKEFGCKDQRKPRMSSDAKEFISIINPHNLKGKSLGQ VSLTHPYSECDFKLKEVARNNMGNDTNEEQEKAVTKIEIISHMKQSTSCLDSEEIRENQGEVILEVQETYCETSGKLPSEQVLQQPMNAR VKSKREKREVIVEESIRTCKPAFLSEEKLYQETAIRDEHDSHIKSQPREMTSSEKGKEADTEMGFSITFKIEESSSQVVPQGISVKHLDA LTLFSSKQANEGKVNNLSLCLTLKPEENLSREIACGAQSEPFPCMTPRPEGLHYQESDGKAQVTGPSQISKTDKSFQGTTRQETNYQDSW VTSKTKETKHQISSSNECKEKSYQEVSFDPARGLKLEEITVSRPDSKEVRYLEFSDRKDLHHQGSKSDDKLCGTLKSEIATQELTGEKFL EMANPNVAGLEAGSIEDIVTQRGSRVLGSFLPEKLFKGVSQKENTGQQNAIISPTVLETSEEKTVSLTVCSAVKTEKTPQEKLRESPGSE QTPFMTAPEGKGNGGVNPEPFRATQNVFTRQLCLEHDEKLVSYLSLLRNIEMRTKQIQPLELNLAELQDLLCQAKVLERELKDLTTLVSQ ELECVNQIIISQPQEVPAQLLKALEKDAKNLQKSLSSVSDTWNSRLLHFQNAVEIEKTKVLNQHTQLEGRLQDLRAWVGNKNLILNSKGS NSEIDVDSLNLCLQQYEDLKQPMAERKAQLDALAFDIQFFISEHAQDLSPQQNRQMLRLLNELQRSFQDILEQTAAQVDALQGHLQQMEQ EALVKTLQKQQNTCHQQLEDLCSWVGQAERALAGHQGRTTQQDLSALQKNQSDLKDLQDDIQNRATSFATVVKDIEGFMEENQTKLSPRE LTALREKLHQAKEQYEALQEETRVAQKELEEAVTSALQQETEKSKAAKELAENKKKIDALLDWVTSVGSSGGQLLTNLPGMEQLSGASLE KGALDTTDGYMGVNQAPEKLDKQCEMMKARHQELLSQQQNFILATQSAQAFLDQHGHNLTPEEQQMLQQKLGELKEQYSTSLAQSEAELK QVQTLQDELQKFLQDHKEFESWLERSEKELENMHKGGSSPETLPSLLKRQGSFSEDVISHKGDLRFVTISGQKVLDMENSFKEGKEPSEI GNLVKDKLKDATERYTALHSKCTRLGSHLNMLLGQYHQFQNSADSLQAWMQACEANVEKLLSDTVASDPGVLQEQLATTKQLQEELAEHQ VPVEKLQKVARDIMEIEGEPAPDHRHVQETTDSILSHFQSLSYSLAERSSLLQKAIAQSQSVQESLESLLQSIGEVEQNLEGKQVSSLSS GVIQEALATNMKLKQDIARQKSSLEATREMVTRFMETADSTTAAVLQGKLAEVSQRFEQLCLQQQEKESSLKKLLPQAEMFEHLSGKLQQ FMENKSRMLASGNQPDQDITHFFQQIQELNLEMEDQQENLDTLEHLVTELSSCGFALDLCQHQDRVQNLRKDFTELQKTVKEREKDASSC QEQLDEFRKLVRTFQKWLKETEGSIPPTETSMSAKELEKQIEHLKSLLDDWASKGTLVEEINCKGTSLENLIMEITAPDSQGKTGSILPS VGSSVGSVNGYHTCKDLTEIQCDMSDVNLKYEKLGGVLHERQESLQAILNRMEEVHKEANSVLQWLESKEEVLKSMDAMSSPTKTETVKA QAESNKAFLAELEQNSPKIQKVKEALAGLLVTYPNSQEAENWKKIQEELNSRWERATEVTVARQRQLEESASHLACFQAAESQLRPWLME KELMMGVLGPLSIDPNMLNAQKQQVQFMLKEFEARRQQHEQLNEAAQGILTGPGDVSLSTSQVQKELQSINQKWVELTDKLNSRSSQIDQ AIVKSTQYQELLQDLSEKVRAVGQRLSVQSAISTQPEAVKQQLEETSEIRSDLEQLDHEVKEAQTLCDELSVLIGEQYLKDELKKRLETV ALPLQGLEDLAADRINRLQAALASTQQFQQMFDELRTWLDDKQSQQAKNCPISAKLERLQSQLQENEEFQKSLNQHSGSYEVIVAEGESL LLSVPPGEEKRTLQNQLVELKNHWEELSKKTADRQSRLKDCMQKAQKYQWHVEDLVPWIEDCKAKMSELRVTLDPVQLESSLLRSKAMLN EVEKRRSLLEILNSAADILINSSEADEDGIRDEKAGINQNMDAVTEELQAKTGSLEEMTQRLREFQESFKNIEKKVEGAKHQLEIFDALG SQACSNKNLEKLRAQQEVLQALEPQVDYLRNFTQGLVEDAPDGSDASQLLHQAEVAQQEFLEVKQRVNSGCVMMENKLEGIGQFHCRVRE MFSQLADLDDELDGMGAIGRDTDSLQSQIEDVRLFLNKIHVLKLDIEASEAECRHMLEEEGTLDLLGLKRELEALNKQCGKLTERGKARQ EQLELTLGRVEDFYRKLKGLNDATTAAEEAEALQWVVGTEVEIINQQLADFKMFQKEQVDPLQMKLQQVNGLGQGLIQSAGKDCDVQGLE HDMEEINARWNTLNKKVAQRIAQLQEALLHCGKFQDALEPLLSWLADTEELIANQKPPSAEYKVVKAQIQEQKLLQRLLDDRKATVDMLQ AEGGRIAQSAELADREKITGQLESLESRWTELLSKAAARQKQLEDILVLAKQFHETAEPISDFLSVTEKKLANSEPVGTQTAKIQQQIIR HKALEEDIENHATDVHQAVKIGQSLSSLTSPAEQGVLSEKIDSLQARYSEIQDRCCRKAALLDQALSNARLFGEDEVEVLNWLAEVEDKL SSVFVKDFKQDVLHRQHADHLALNEEIVNRKKNVDQAIKNGQALLKQTTGEEVLLIQEKLDGIKTRYADITVTSSKALRTLEQARQLATK FQSTYEELTGWLREVEEELATSGGQSPTGEQIPQFQQRQKELKKEVMEHRLVLDTVNEVSRALLELVPWRAREGLDKLVSDANEQYKLVS DTIGQRVDEIDAAIQRSQQYEQAADAELAWVAETKRKLMALGPIRLEQDQTTAQLQVQKAFSIDIIRHKDSMDELFSHRSEIFGTCGEEQ KTVLQEKTESLIQQYEAISLLNSERYARLERAQVLVNQFWETYEELSPWIEETRALIAQLPSPAIDHEQLRQQQEEMRQLRESIAEHKPH IDKLLKIGPQLKELNPEEGEMVEEKYQKAENMYAQIKEEVRQRALALDEAVSQSTQFHDKIEPMLETLENLSSRLRMPPLIPAEVDKIRE CISDNKSATVELEKLQPSFEALKRRGEELIGRSQGADKDLAAKEIQDKLDQMVFFWEDIKARAEEREIKFLDVLELAEKFWYDMAALLTT IKDTQDIVHDLESPGIDPSIIKQQVEAAETIKEETDGLHEELEFIRILGADLIFACGETEKPEVRKSIDEMNNAWENLNKTWKERLEKLE DAMQAAVQYQDTLQAMFDWLDNTVIKLCTMPPVGTDLNTVKDQLNEMKEFKVEVYQQQIEMEKLNHQGELMLKKATDETDRDIIREPLTE LKHLWENLGEKIAHRQHKLEGALLALGQFQHALEELMSWLTHTEELLDAQRPISGDPKVIEVELAKHHVLKNDVLAHQATVETVNKAGNE LLESSAGDDASSLRSRLEAMNQCWESVLQKTEEREQQLQSTLQQAQGFHSEIEDFLLELTRMESQLSASKPTGGLPETAREQLDTHMELY SQLKAKEETYNQLLDKGRLMLLSRDDSGSGSKTEQSVALLEQKWHVVSSKMEERKSKLEEALNLATEFQNSLQEFINWLTLAEQSLNIAS PPSLILNTVLSQIEEHKVFANEVNAHRDQIIELDQTGNQLKFLSQKQDVVLIKNLLVSVQSRWEKVVQRSIERGRSLDDARKRAKQFHEA WKKLIDWLEDAESHLDSELEISNDPDKIKLQLSKHKEFQKTLGGKQPVYDTTIRTGRALKEKTLLPEDSQKLDNFLGEVRDKWDTVCGKS VERQHKLEEALLFSGQFMDALQALVDWLYKVEPQLAEDQPVHGDLDLVMNLMDAHKVFQKELGKRTGTVQVLKRSGRELIENSRDDTTWV KGQLQELSTRWDTVCKLSVSKQSRLEQALKQAEVFRDTVHMLLEWLSEAEQTLRFRGALPDDTEALQSLIDTHKEFMKKVEEKRVDVNSA VAMGEVILAVCHPDCITTIKHWITIIRARFEEVLTWAKQHQQRLETALSELVANAELLEELLAWIQWAETTLIQRDQEPIPQNIDRVKAL IAEHQTFMEEMTRKQPDVDRVTKTYKRKNIEPTHAPFIEKSRSGGRKSLSQPTPPPMPILSQSEAKNPRINQLSARWQQVWLLALERQRK LNDALDRLEELKEFANFDFDVWRKKYMRWMNHKKSRVMDFFRRIDKDQDGKITRQEFIDGILASKFPTTKLEMTAVADIFDRDGDGYIDY YEFVAALHPNKDAYRPTTDADKIEDEVTRQVAQCKCAKRFQVEQIGENKYRFFLGNQFGDSQQLRLVRILRSTVMVRVGGGWMALDEFLV KNDPCRVHHPGSKIKRSDSSSSISSQSPIARGRTNIELREKFILPEGASQGMTPFRSRGRRSKPSSRAASPTRSSSSASQSNHSCTSMPS SPATPASGTKTSLQFSRCYDKPWLVNSKAGTPIRDSHSPDLQLPTPEVIPSSGSKLKRPTPTFHSSRTSLAGDTSNSSSPASTGAKTNRA -------------------------------------------------------------- >59734_59734_7_NOTCH2-MACF1_NOTCH2_chr1_120572529_ENST00000256646_MACF1_chr1_39775242_ENST00000567887_length(amino acids)=6745AA_BP=120 MRRRPRSGGLGARGVEAFAPGLRSVAPGPEPLKQEEGRREWGSSIGTPSPCGSAQAAAAAAEEEATEKMPALRPALLWALLALWLCCAAP AHALQCRDGYEPCVNEGMCVTYHNGTGYCKVEQSYQKVMALWHQLHVNTKSLISWNYLRKDLDLVQTWNLEKLRSSAPGECHQIMKNLQA HYEDFLQDSRDSVLFSVADRLRLEEEVEACKARFQHLMKSMENEDKEETVAKMYISELKNIRLRLEEYEQRVVKRIQSLASSRTDRDAWQ DNALRIAEQEHTQEDLQQLRSDLDAVSMKCDSFLHQSPSSSSVPTLRSELNLLVEKMDHVYGLSTVYLNKLKTVDVIVRSIQDAELLVKG YEIKLSQEEVVLADLSALEAHWSTLRHWLSDVKDKNSVFSVLDEEIAKAKVVAEQMSRLTPERNLDLERYQEKGSQLQERWHRVIAQLEI RQSELESIQEVLGDYRACHGTLIKWIEETTAQQEMMKPGQAEDSRVLSEQLSQQTALFAEIERNQTKLDQCQKFSQQYSTIVKDYELQLM TYKAFVESQQKSPGKRRRMLSSSDAITQEFMDLRTRYTALVTLTTQHVKYISDALRRLEEEEKVVEEEKQEHVEKVKELLGWVSTLARNT QGKATSSETKESTDIEKAILEQQVLSEELTTKKEQVSEAIKTSQIFLAKHGHKLSEKEKKQISEQLNALNKAYHDLCDGSANQLQQLQSQ LAHQTEQKECRAVAGVIDLGTVEIFPIFKAMQKGLLDQDTGLVLLESQVIMSGLIAPETGENLSLEEGIARNLINPQMYQQLRELQDALA LISRLTESRGPLSVVEAIEKRIISETVGLKILEAHLATGGFSLSPSENCINLEEAFHQGLISAWLHSVLESYLRTSKNLIDPNTAEKIGL LDLMQRCIVHQESGFKLLPVKQLAGGMVSLKSGRKVSIFRAVQEGLIDRQVTVRLLEAQLFAGGIVDPRTGHRLTVEEAVRHNLIDQDMA CAILIRQLQTGGIIDTVTGQRLTIDEAVSNDLVAAKIALVILESLWSFMGLLWPESGEILPITDALEQGIVSTELAHKILSNRQHIKALF LPATTEILSWKKAIESGILDRDLANNLKSICIPDVMPHMQLADSAEQNINPGAAVLPCSKSHPKATASQSENLLFQLMTHSYINVQNGQR LLLLDKELMETLTSRDEYQTSPPKVVEIGHQRQKTPEGLQESANVKISGTFSSGWTVRLPEFQFSSQNKEYPDREDCTTEKGKKTTVETE DSSVENPEQDLFVEQKERNPNIDALKVINKVKLEVQRQLIGTQREDQTAVSVRENASRGHLLTIPPAEAEGVPLVVDKDVFSVETPKKEH QPLRNTSFTCQNEQAHTLETEYIHDETGGSHIKPQSKKLQVQVKKTLGIKLELKSETDGNVHPLDKKEMLKKTFLAKDDHKESQEAQNIA GGSMMMSEKTDEEDSGREIFLSCSHPLELLEEATLNVLSAQLLDGGIFHEQTGQKLLLNEAISRGIVPSHTAVKLMEKLNMFQGFFDSQT CESLTTEEVINEGLMDEKLLHNVLMADKAISGVLDPRTQTLCSVKDAVTVGLLDKETATRILERQVVTGGIIDLKRGKKVSVTLASTLGL VDVADQPELINLEKASKGRDAEKTVRERLISLQMETTGLIDPDSKAPLTVVQSIDRGLLEREEAVRLLTKQVVDGGIIHHISGMRLSVDN AFRHGLIGEDLAEKLKRVENLNIHQIFNPETKENISLPKAIKLDLITSDLKREIQEVQAFTGNFVDLISGQRLTLAEAKKEGLLTNEAVL SPGMMHGIVDPENCRIVPYSELVKKCKIDIESGQRYLEVIPFSDIKDGVSDKVLTLSQAIQLGKVDFASTLKVLEAQANTGGIIDTATGK RLTLASALEEKLVDENMVRIIASHQVLNGGIVDIFSDQRVTLVEAIEKRLISPELANMIQIDSSEFSDHRAQIEKQEGIEVCALQNEFLG KDMLIACNQTAEMSCNKVEESERLFQVENQSAQEKVKVRVSDGEQAKKSREISLKEFGCKDQRKPRMSSDAKEFISIINPHNLKGKSLGQ VSLTHPYSECDFKLKEVARNNMGNDTNEEQEKAVTKIEIISHMKQSTSCLDSEEIRENQGEVILEVQETYCETSGKLPSEQVLQQPMNAR VKSKREKREVIVEESIRTCKPAFLSEEKLYQETAIRDEHDSHIKSQPREMTSSEKGKEADTEMGFSITFKIEESSSQVVPQGISVKHLDA LTLFSSKQANEGKVNNLSLCLTLKPEENLSREIACGAQSEPFPCMTPRPEGLHYQESDGKAQVTGPSQISKTDKSFQGTTRQETNYQDSW VTSKTKETKHQISSSNECKEKSYQEVSFDPARGLKLEEITVSRPDSKEVRYLEFSDRKDLHHQGSKSDDKLCGTLKSEIATQELTGEKFL EMANPNVAGLEAGSIEDIVTQRGSRVLGSFLPEKLFKGVSQKENTGQQNAIISPTVLETSEEKTVSLTVCSAVKTEKTPQEKLRESPGSE QTPFMTAPEGKGNGGVNPEPFRATQNVFTRQLCLEHDEKLVSYLSLLRNIEMRTKQIQPLELNLAELQDLLCQAKVLERELKDLTTLVSQ ELECVNQIIISQPQEVPAQLLKALEKDAKNLQKSLSSVSDTWNSRLLHFQNAVEIEKTKVLNQHTQLEGRLQDLRAWVGNKNLILNSKGS NSEIDVDSLNLCLQQYEDLKQPMAERKAQLDALAFDIQFFISEHAQDLSPQQNRQMLRLLNELQRSFQDILEQTAAQVDALQGHLQQMEQ EALVKTLQKQQNTCHQQLEDLCSWVGQAERALAGHQGRTTQQDLSALQKNQSDLKDLQDDIQNRATSFATVVKDIEGFMEENQTKLSPRE LTALREKLHQAKEQYEALQEETRVAQKELEEAVTSALQQETEKSKAAKELAENKKKIDALLDWVTSVGSSGGQLLTNLPGMEQLSGASLE KGALDTTDGYMGVNQAPEKLDKQCEMMKARHQELLSQQQNFILATQSAQAFLDQHGHNLTPEEQQMLQQKLGELKEQYSTSLAQSEAELK QVQTLQDELQKFLQDHKEFESWLERSEKELENMHKGGSSPETLPSLLKRQGSFSEDVISHKGDLRFVTISGQKVLDMENSFKEGKEPSEI GNLVKDKLKDATERYTALHSKCTRLGSHLNMLLGQYHQFQNSADSLQAWMQACEANVEKLLSDTVASDPGVLQEQLATTKQLQEELAEHQ VPVEKLQKVARDIMEIEGEPAPDHRHVQETTDSILSHFQSLSYSLAERSSLLQKAIAQSQSVQESLESLLQSIGEVEQNLEGKQVSSLSS GVIQEALATNMKLKQDIARQKSSLEATREMVTRFMETADSTTAAVLQGKLAEVSQRFEQLCLQQQEKESSLKKLLPQAEMFEHLSGKLQQ FMENKSRMLASGNQPDQDITHFFQQIQELNLEMEDQQENLDTLEHLVTELSSCGFALDLCQHQDRVQNLRKDFTELQKTVKEREKDASSC QEQLDEFRKLVRTFQKWLKETEGSIPPTETSMSAKELEKQIEHLKSLLDDWASKGTLVEEINCKGTSLENLIMEITAPDSQGKTGSILPS VGSSVGSVNGYHTCKDLTEIQCDMSDVNLKYEKLGGVLHERQESLQAILNRMEEVHKEANSVLQWLESKEEVLKSMDAMSSPTKTETVKA QAESNKAFLAELEQNSPKIQKVKEALAGLLVTYPNSQEAENWKKIQEELNSRWERATEVTVARQRQLEESASHLACFQAAESQLRPWLME KELMMGVLGPLSIDPNMLNAQKQQVQFMLKEFEARRQQHEQLNEAAQGILTGPGDVSLSTSQVQKELQSINQKWVELTDKLNSRSSQIDQ AIVKSTQYQELLQDLSEKVRAVGQRLSVQSAISTQPEAVKQQLEETSEIRSDLEQLDHEVKEAQTLCDELSVLIGEQYLKDELKKRLETV ALPLQGLEDLAADRINRLQAALASTQQFQQMFDELRTWLDDKQSQQAKNCPISAKLERLQSQLQENEEFQKSLNQHSGSYEVIVAEGESL LLSVPPGEEKRTLQNQLVELKNHWEELSKKTADRQSRLKDCMQKAQKYQWHVEDLVPWIEDCKAKMSELRVTLDPVQLESSLLRSKAMLN EVEKRRSLLEILNSAADILINSSEADEDGIRDEKAGINQNMDAVTEELQAKTGSLEEMTQRLREFQESFKNIEKKVEGAKHQLEIFDALG SQACSNKNLEKLRAQQEVLQALEPQVDYLRNFTQGLVEDAPDGSDASQLLHQAEVAQQEFLEVKQRVNSGCVMMENKLEGIGQFHCRVRE MFSQLADLDDELDGMGAIGRDTDSLQSQIEDVRLFLNKIHVLKLDIEASEAECRHMLEEEGTLDLLGLKRELEALNKQCGKLTERGKARQ EQLELTLGRVEDFYRKLKGLNDATTAAEEAEALQWVVGTEVEIINQQLADFKMFQKEQVDPLQMKLQQVNGLGQGLIQSAGKDCDVQGLE HDMEEINARWNTLNKKVAQRIAQLQEALLHCGKFQDALEPLLSWLADTEELIANQKPPSAEYKVVKAQIQEQKLLQRLLDDRKATVDMLQ AEGGRIAQSAELADREKITGQLESLESRWTELLSKAAARQKQLEDILVLAKQFHETAEPISDFLSVTEKKLANSEPVGTQTAKIQQQIIR HKALEEDIENHATDVHQAVKIGQSLSSLTSPAEQGVLSEKIDSLQARYSEIQDRCCRKAALLDQALSNARLFGEDEVEVLNWLAEVEDKL SSVFVKDFKQDVLHRQHADHLALNEEIVNRKKNVDQAIKNGQALLKQTTGEEVLLIQEKLDGIKTRYADITVTSSKALRTLEQARQLATK FQSTYEELTGWLREVEEELATSGGQSPTGEQIPQFQQRQKELKKEVMEHRLVLDTVNEVSRALLELVPWRAREGLDKLVSDANEQYKLVS DTIGQRVDEIDAAIQRSQQYEQAADAELAWVAETKRKLMALGPIRLEQDQTTAQLQVQKAFSIDIIRHKDSMDELFSHRSEIFGTCGEEQ KTVLQEKTESLIQQYEAISLLNSERYARLERAQVLVNQFWETYEELSPWIEETRALIAQLPSPAIDHEQLRQQQEEMRQLRESIAEHKPH IDKLLKIGPQLKELNPEEGEMVEEKYQKAENMYAQIKEEVRQRALALDEAVSQSTQFHDKIEPMLETLENLSSRLRMPPLIPAEVDKIRE CISDNKSATVELEKLQPSFEALKRRGEELIGRSQGADKDLAAKEIQDKLDQMVFFWEDIKARAEEREIKFLDVLELAEKFWYDMAALLTT IKDTQDIVHDLESPGIDPSIIKQQVEAAETIKEETDGLHEELEFIRILGADLIFACGETEKPEVRKSIDEMNNAWENLNKTWKERLEKLE DAMQAAVQYQDTLQAMFDWLDNTVIKLCTMPPVGTDLNTVKDQLNEMKEFKVEVYQQQIEMEKLNHQGELMLKKATDETDRDIIREPLTE LKHLWENLGEKIAHRQHKLEGALLALGQFQHALEELMSWLTHTEELLDAQRPISGDPKVIEVELAKHHVLKNDVLAHQATVETVNKAGNE LLESSAGDDASSLRSRLEAMNQCWESVLQKTEEREQQLQSTLQQAQGFHSEIEDFLLELTRMESQLSASKPTGGLPETAREQLDTHMELY SQLKAKEETYNQLLDKGRLMLLSRDDSGSGSKTEQSVALLEQKWHVVSSKMEERKSKLEEALNLATEFQNSLQEFINWLTLAEQSLNIAS PPSLILNTVLSQIEEHKVFANEVNAHRDQIIELDQTGNQLKFLSQKQDVVLIKNLLVSVQSRWEKVVQRSIERGRSLDDARKRAKQFHEA WKKLIDWLEDAESHLDSELEISNDPDKIKLQLSKHKEFQKTLGGKQPVYDTTIRTGRALKEKTLLPEDSQKLDNFLGEVRDKWDTVCGKS VERQHKLEEALLFSGQFMDALQALVDWLYKVEPQLAEDQPVHGDLDLVMNLMDAHKVFQKELGKRTGTVQVLKRSGRELIENSRDDTTWV KGQLQELSTRWDTVCKLSVSKQSRLEQALKQAEVFRDTVHMLLEWLSEAEQTLRFRGALPDDTEALQSLIDTHKEFMKKVEEKRVDVNSA VAMGEVILAVCHPDCITTIKHWITIIRARFEEVLTWAKQHQQRLETALSELVANAELLEELLAWIQWAETTLIQRDQEPIPQNIDRVKAL IAEHQTFMEEMTRKQPDVDRVTKTYKRKNIEPTHAPFIEKSRSGGRKSLSQPTPPPMPILSQSEAKNPRINQLSARWQQVWLLALERQRK LNDALDRLEELKEFANFDFDVWRKKYMRWMNHKKSRVMDFFRRIDKDQDGKITRQEFIDGILASKFPTTKLEMTAVADIFDRDGDGYIDY YEFVAALHPNKDAYRPTTDADKIEDEVTRQVAQCKCAKRFQVEQIGENKYRFFLGNQFGDSQQLRLVRILRSTVMVRVGGGWMALDEFLV KNDPCRVHHPGSKIKRSDSSSSISSQSPIARGRTNIELREKFILPEGASQGMTPFRSRGRRSKPSSRAASPTRSSSSASQSNHSCTSMPS SPATPASGTKTSLQFSRCYDKPWLVNSKAGTPIRDSHSPDLQLPTPEVIPSSGSKLKRPTPTFHSSRTSLAGDTSNSSSPASTGAKTNRA -------------------------------------------------------------- |
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Fusion Protein Functional Features |
| Four levels of functional features of fusion genes Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr1:120572529/chr1:39775242) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
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| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| NOTCH2 | MACF1 |
| FUNCTION: Human-specific protein that promotes neural progenitor proliferation and evolutionary expansion of the brain neocortex by regulating the Notch signaling pathway (PubMed:29856954, PubMed:29856955, PubMed:29561261). Able to promote neural progenitor self-renewal, possibly by down-regulating neuronal differentiation genes, thereby delaying the differentiation of neuronal progenitors and leading to an overall final increase in neuronal production (PubMed:29856954, PubMed:29856955). Acts by enhancing the Notch signaling pathway via two different mechanisms that probably work in parallel to reach the same effect (PubMed:29856954, PubMed:29856955). Enhances Notch signaling pathway in a non-cell-autonomous manner via direct interaction with NOTCH2 (PubMed:29856954). Also promotes Notch signaling pathway in a cell-autonomous manner through inhibition of cis DLL1-NOTCH2 interactions, which promotes neuronal differentiation (PubMed:29856955). {ECO:0000269|PubMed:29561261, ECO:0000269|PubMed:29856954, ECO:0000269|PubMed:29856955}. | FUNCTION: [Isoform 2]: F-actin-binding protein which plays a role in cross-linking actin to other cytoskeletal proteins and also binds to microtubules (PubMed:15265687, PubMed:20937854). Plays an important role in ERBB2-dependent stabilization of microtubules at the cell cortex (PubMed:20937854). Acts as a positive regulator of Wnt receptor signaling pathway and is involved in the translocation of AXIN1 and its associated complex (composed of APC, CTNNB1 and GSK3B) from the cytoplasm to the cell membrane (By similarity). Has actin-regulated ATPase activity and is essential for controlling focal adhesions (FAs) assembly and dynamics (By similarity). Interaction with CAMSAP3 at the minus ends of non-centrosomal microtubules tethers microtubules minus-ends to actin filaments, regulating focal adhesion size and cell migration (PubMed:27693509). May play role in delivery of transport vesicles containing GPI-linked proteins from the trans-Golgi network through its interaction with GOLGA4 (PubMed:15265687). Plays a key role in wound healing and epidermal cell migration (By similarity). Required for efficient upward migration of bulge cells in response to wounding and this function is primarily rooted in its ability to coordinate microtubule dynamics and polarize hair follicle stem cells (By similarity). As a regulator of actin and microtubule arrangement and stabilization, it plays an essential role in neurite outgrowth, branching and spine formation during brain development (By similarity). {ECO:0000250|UniProtKB:Q9QXZ0, ECO:0000269|PubMed:15265687, ECO:0000269|PubMed:20937854, ECO:0000269|PubMed:27693509}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
| - Retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Tgene | MACF1 | chr1:120572529 | chr1:39775242 | ENST00000289893 | 0 | 64 | 7054_7065 | 0 | 5939.0 | Calcium binding | 1 | |
| Tgene | MACF1 | chr1:120572529 | chr1:39775242 | ENST00000289893 | 0 | 64 | 7090_7101 | 0 | 5939.0 | Calcium binding | 2 | |
| Tgene | MACF1 | chr1:120572529 | chr1:39775242 | ENST00000361689 | 21 | 93 | 7054_7065 | 934.6666666666666 | 5431.0 | Calcium binding | 1 | |
| Tgene | MACF1 | chr1:120572529 | chr1:39775242 | ENST00000361689 | 21 | 93 | 7090_7101 | 934.6666666666666 | 5431.0 | Calcium binding | 2 | |
| Tgene | MACF1 | chr1:120572529 | chr1:39775242 | ENST00000372915 | 21 | 97 | 7054_7065 | 934.6666666666666 | 7389.0 | Calcium binding | 1 | |
| Tgene | MACF1 | chr1:120572529 | chr1:39775242 | ENST00000372915 | 21 | 97 | 7090_7101 | 934.6666666666666 | 7389.0 | Calcium binding | 2 | |
| Tgene | MACF1 | chr1:120572529 | chr1:39775242 | ENST00000545844 | 22 | 94 | 7054_7065 | 934.6666666666666 | 5431.0 | Calcium binding | 1 | |
| Tgene | MACF1 | chr1:120572529 | chr1:39775242 | ENST00000545844 | 22 | 94 | 7090_7101 | 934.6666666666666 | 5431.0 | Calcium binding | 2 | |
| Tgene | MACF1 | chr1:120572529 | chr1:39775242 | ENST00000289893 | 0 | 64 | 1122_1127 | 0 | 5939.0 | Compositional bias | Note=Poly-Ser | |
| Tgene | MACF1 | chr1:120572529 | chr1:39775242 | ENST00000289893 | 0 | 64 | 1414_1417 | 0 | 5939.0 | Compositional bias | Note=Poly-Glu | |
| Tgene | MACF1 | chr1:120572529 | chr1:39775242 | ENST00000289893 | 0 | 64 | 1986_1989 | 0 | 5939.0 | Compositional bias | Note=Poly-Leu | |
| Tgene | MACF1 | chr1:120572529 | chr1:39775242 | ENST00000289893 | 0 | 64 | 698_703 | 0 | 5939.0 | Compositional bias | Note=Poly-Glu | |
| Tgene | MACF1 | chr1:120572529 | chr1:39775242 | ENST00000289893 | 0 | 64 | 7222_7351 | 0 | 5939.0 | Compositional bias | Note=Ser-rich | |
| Tgene | MACF1 | chr1:120572529 | chr1:39775242 | ENST00000361689 | 21 | 93 | 1122_1127 | 934.6666666666666 | 5431.0 | Compositional bias | Note=Poly-Ser | |
| Tgene | MACF1 | chr1:120572529 | chr1:39775242 | ENST00000361689 | 21 | 93 | 1414_1417 | 934.6666666666666 | 5431.0 | Compositional bias | Note=Poly-Glu | |
| Tgene | MACF1 | chr1:120572529 | chr1:39775242 | ENST00000361689 | 21 | 93 | 1986_1989 | 934.6666666666666 | 5431.0 | Compositional bias | Note=Poly-Leu | |
| Tgene | MACF1 | chr1:120572529 | chr1:39775242 | ENST00000361689 | 21 | 93 | 7222_7351 | 934.6666666666666 | 5431.0 | Compositional bias | Note=Ser-rich | |
| Tgene | MACF1 | chr1:120572529 | chr1:39775242 | ENST00000372915 | 21 | 97 | 1122_1127 | 934.6666666666666 | 7389.0 | Compositional bias | Note=Poly-Ser | |
| Tgene | MACF1 | chr1:120572529 | chr1:39775242 | ENST00000372915 | 21 | 97 | 1414_1417 | 934.6666666666666 | 7389.0 | Compositional bias | Note=Poly-Glu | |
| Tgene | MACF1 | chr1:120572529 | chr1:39775242 | ENST00000372915 | 21 | 97 | 1986_1989 | 934.6666666666666 | 7389.0 | Compositional bias | Note=Poly-Leu | |
| Tgene | MACF1 | chr1:120572529 | chr1:39775242 | ENST00000372915 | 21 | 97 | 7222_7351 | 934.6666666666666 | 7389.0 | Compositional bias | Note=Ser-rich | |
| Tgene | MACF1 | chr1:120572529 | chr1:39775242 | ENST00000545844 | 22 | 94 | 1122_1127 | 934.6666666666666 | 5431.0 | Compositional bias | Note=Poly-Ser | |
| Tgene | MACF1 | chr1:120572529 | chr1:39775242 | ENST00000545844 | 22 | 94 | 1414_1417 | 934.6666666666666 | 5431.0 | Compositional bias | Note=Poly-Glu | |
| Tgene | MACF1 | chr1:120572529 | chr1:39775242 | ENST00000545844 | 22 | 94 | 1986_1989 | 934.6666666666666 | 5431.0 | Compositional bias | Note=Poly-Leu | |
| Tgene | MACF1 | chr1:120572529 | chr1:39775242 | ENST00000545844 | 22 | 94 | 7222_7351 | 934.6666666666666 | 5431.0 | Compositional bias | Note=Ser-rich | |
| Tgene | MACF1 | chr1:120572529 | chr1:39775242 | ENST00000289893 | 0 | 64 | 194_298 | 0 | 5939.0 | Domain | Calponin-homology (CH) 2 | |
| Tgene | MACF1 | chr1:120572529 | chr1:39775242 | ENST00000289893 | 0 | 64 | 7041_7076 | 0 | 5939.0 | Domain | EF-hand 1 | |
| Tgene | MACF1 | chr1:120572529 | chr1:39775242 | ENST00000289893 | 0 | 64 | 7077_7112 | 0 | 5939.0 | Domain | EF-hand 2 | |
| Tgene | MACF1 | chr1:120572529 | chr1:39775242 | ENST00000289893 | 0 | 64 | 7117_7189 | 0 | 5939.0 | Domain | GAR | |
| Tgene | MACF1 | chr1:120572529 | chr1:39775242 | ENST00000289893 | 0 | 64 | 78_181 | 0 | 5939.0 | Domain | Calponin-homology (CH) 1 | |
| Tgene | MACF1 | chr1:120572529 | chr1:39775242 | ENST00000289893 | 0 | 64 | 868_925 | 0 | 5939.0 | Domain | SH3 | |
| Tgene | MACF1 | chr1:120572529 | chr1:39775242 | ENST00000361689 | 21 | 93 | 7041_7076 | 934.6666666666666 | 5431.0 | Domain | EF-hand 1 | |
| Tgene | MACF1 | chr1:120572529 | chr1:39775242 | ENST00000361689 | 21 | 93 | 7077_7112 | 934.6666666666666 | 5431.0 | Domain | EF-hand 2 | |
| Tgene | MACF1 | chr1:120572529 | chr1:39775242 | ENST00000361689 | 21 | 93 | 7117_7189 | 934.6666666666666 | 5431.0 | Domain | GAR | |
| Tgene | MACF1 | chr1:120572529 | chr1:39775242 | ENST00000372915 | 21 | 97 | 7041_7076 | 934.6666666666666 | 7389.0 | Domain | EF-hand 1 | |
| Tgene | MACF1 | chr1:120572529 | chr1:39775242 | ENST00000372915 | 21 | 97 | 7077_7112 | 934.6666666666666 | 7389.0 | Domain | EF-hand 2 | |
| Tgene | MACF1 | chr1:120572529 | chr1:39775242 | ENST00000372915 | 21 | 97 | 7117_7189 | 934.6666666666666 | 7389.0 | Domain | GAR | |
| Tgene | MACF1 | chr1:120572529 | chr1:39775242 | ENST00000545844 | 22 | 94 | 7041_7076 | 934.6666666666666 | 5431.0 | Domain | EF-hand 1 | |
| Tgene | MACF1 | chr1:120572529 | chr1:39775242 | ENST00000545844 | 22 | 94 | 7077_7112 | 934.6666666666666 | 5431.0 | Domain | EF-hand 2 | |
| Tgene | MACF1 | chr1:120572529 | chr1:39775242 | ENST00000545844 | 22 | 94 | 7117_7189 | 934.6666666666666 | 5431.0 | Domain | GAR | |
| Tgene | MACF1 | chr1:120572529 | chr1:39775242 | ENST00000289893 | 0 | 64 | 1_295 | 0 | 5939.0 | Region | Note=Actin-binding | |
| Tgene | MACF1 | chr1:120572529 | chr1:39775242 | ENST00000289893 | 0 | 64 | 7117_7388 | 0 | 5939.0 | Region | C-terminal tail | |
| Tgene | MACF1 | chr1:120572529 | chr1:39775242 | ENST00000289893 | 0 | 64 | 7313_7328 | 0 | 5939.0 | Region | Note=4 X 4 AA tandem repeats of [GS]-S-R-[AR] | |
| Tgene | MACF1 | chr1:120572529 | chr1:39775242 | ENST00000361689 | 21 | 93 | 7117_7388 | 934.6666666666666 | 5431.0 | Region | C-terminal tail | |
| Tgene | MACF1 | chr1:120572529 | chr1:39775242 | ENST00000361689 | 21 | 93 | 7313_7328 | 934.6666666666666 | 5431.0 | Region | Note=4 X 4 AA tandem repeats of [GS]-S-R-[AR] | |
| Tgene | MACF1 | chr1:120572529 | chr1:39775242 | ENST00000372915 | 21 | 97 | 7117_7388 | 934.6666666666666 | 7389.0 | Region | C-terminal tail | |
| Tgene | MACF1 | chr1:120572529 | chr1:39775242 | ENST00000372915 | 21 | 97 | 7313_7328 | 934.6666666666666 | 7389.0 | Region | Note=4 X 4 AA tandem repeats of [GS]-S-R-[AR] | |
| Tgene | MACF1 | chr1:120572529 | chr1:39775242 | ENST00000545844 | 22 | 94 | 7117_7388 | 934.6666666666666 | 5431.0 | Region | C-terminal tail | |
| Tgene | MACF1 | chr1:120572529 | chr1:39775242 | ENST00000545844 | 22 | 94 | 7313_7328 | 934.6666666666666 | 5431.0 | Region | Note=4 X 4 AA tandem repeats of [GS]-S-R-[AR] | |
| Tgene | MACF1 | chr1:120572529 | chr1:39775242 | ENST00000289893 | 0 | 64 | 1050_1073 | 0 | 5939.0 | Repeat | Note=LRR 5 | |
| Tgene | MACF1 | chr1:120572529 | chr1:39775242 | ENST00000289893 | 0 | 64 | 1128_1154 | 0 | 5939.0 | Repeat | Note=LRR 6 | |
| Tgene | MACF1 | chr1:120572529 | chr1:39775242 | ENST00000289893 | 0 | 64 | 1187_1210 | 0 | 5939.0 | Repeat | Note=LRR 7 | |
| Tgene | MACF1 | chr1:120572529 | chr1:39775242 | ENST00000289893 | 0 | 64 | 1257_1282 | 0 | 5939.0 | Repeat | Note=LRR 8 | |
| Tgene | MACF1 | chr1:120572529 | chr1:39775242 | ENST00000289893 | 0 | 64 | 148_171 | 0 | 5939.0 | Repeat | Note=LRR 1 | |
| Tgene | MACF1 | chr1:120572529 | chr1:39775242 | ENST00000289893 | 0 | 64 | 1577_1621 | 0 | 5939.0 | Repeat | Note=Plectin 1 | |
| Tgene | MACF1 | chr1:120572529 | chr1:39775242 | ENST00000289893 | 0 | 64 | 1654_1696 | 0 | 5939.0 | Repeat | Note=Plectin 2 | |
| Tgene | MACF1 | chr1:120572529 | chr1:39775242 | ENST00000289893 | 0 | 64 | 1769_1809 | 0 | 5939.0 | Repeat | Note=Plectin 3 | |
| Tgene | MACF1 | chr1:120572529 | chr1:39775242 | ENST00000289893 | 0 | 64 | 1811_1848 | 0 | 5939.0 | Repeat | Note=Plectin 4 | |
| Tgene | MACF1 | chr1:120572529 | chr1:39775242 | ENST00000289893 | 0 | 64 | 1855_1886 | 0 | 5939.0 | Repeat | Note=Plectin 5 | |
| Tgene | MACF1 | chr1:120572529 | chr1:39775242 | ENST00000289893 | 0 | 64 | 2290_2332 | 0 | 5939.0 | Repeat | Note=Plectin 6 | |
| Tgene | MACF1 | chr1:120572529 | chr1:39775242 | ENST00000289893 | 0 | 64 | 2367_2410 | 0 | 5939.0 | Repeat | Note=Plectin 7 | |
| Tgene | MACF1 | chr1:120572529 | chr1:39775242 | ENST00000289893 | 0 | 64 | 240_264 | 0 | 5939.0 | Repeat | Note=LRR 2 | |
| Tgene | MACF1 | chr1:120572529 | chr1:39775242 | ENST00000289893 | 0 | 64 | 2411_2437 | 0 | 5939.0 | Repeat | Note=Plectin 8 | |
| Tgene | MACF1 | chr1:120572529 | chr1:39775242 | ENST00000289893 | 0 | 64 | 2501_2543 | 0 | 5939.0 | Repeat | Note=Plectin 9 | |
| Tgene | MACF1 | chr1:120572529 | chr1:39775242 | ENST00000289893 | 0 | 64 | 2581_2612 | 0 | 5939.0 | Repeat | Note=Plectin 10 | |
| Tgene | MACF1 | chr1:120572529 | chr1:39775242 | ENST00000289893 | 0 | 64 | 2686_2730 | 0 | 5939.0 | Repeat | Note=Plectin 11 | |
| Tgene | MACF1 | chr1:120572529 | chr1:39775242 | ENST00000289893 | 0 | 64 | 3239_3262 | 0 | 5939.0 | Repeat | Note=LRR 9 | |
| Tgene | MACF1 | chr1:120572529 | chr1:39775242 | ENST00000289893 | 0 | 64 | 3264_3283 | 0 | 5939.0 | Repeat | Note=LRR 10 | |
| Tgene | MACF1 | chr1:120572529 | chr1:39775242 | ENST00000289893 | 0 | 64 | 3646_3669 | 0 | 5939.0 | Repeat | Note=LRR 11 | |
| Tgene | MACF1 | chr1:120572529 | chr1:39775242 | ENST00000289893 | 0 | 64 | 3696_3720 | 0 | 5939.0 | Repeat | Note=LRR 12 | |
| Tgene | MACF1 | chr1:120572529 | chr1:39775242 | ENST00000289893 | 0 | 64 | 377_399 | 0 | 5939.0 | Repeat | Note=LRR 3 | |
| Tgene | MACF1 | chr1:120572529 | chr1:39775242 | ENST00000289893 | 0 | 64 | 3883_3957 | 0 | 5939.0 | Repeat | Note=Spectrin 1 | |
| Tgene | MACF1 | chr1:120572529 | chr1:39775242 | ENST00000289893 | 0 | 64 | 3936_3958 | 0 | 5939.0 | Repeat | Note=LRR 13 | |
| Tgene | MACF1 | chr1:120572529 | chr1:39775242 | ENST00000289893 | 0 | 64 | 4000_4108 | 0 | 5939.0 | Repeat | Note=Spectrin 2 | |
| Tgene | MACF1 | chr1:120572529 | chr1:39775242 | ENST00000289893 | 0 | 64 | 4125_4150 | 0 | 5939.0 | Repeat | Note=LRR 14 | |
| Tgene | MACF1 | chr1:120572529 | chr1:39775242 | ENST00000289893 | 0 | 64 | 4261_4287 | 0 | 5939.0 | Repeat | Note=LRR 15 | |
| Tgene | MACF1 | chr1:120572529 | chr1:39775242 | ENST00000289893 | 0 | 64 | 441_464 | 0 | 5939.0 | Repeat | Note=LRR 4 | |
| Tgene | MACF1 | chr1:120572529 | chr1:39775242 | ENST00000289893 | 0 | 64 | 4466_4574 | 0 | 5939.0 | Repeat | Note=Spectrin 3 | |
| Tgene | MACF1 | chr1:120572529 | chr1:39775242 | ENST00000289893 | 0 | 64 | 4511_4534 | 0 | 5939.0 | Repeat | Note=LRR 16 | |
| Tgene | MACF1 | chr1:120572529 | chr1:39775242 | ENST00000289893 | 0 | 64 | 4601_4624 | 0 | 5939.0 | Repeat | Note=LRR 17 | |
| Tgene | MACF1 | chr1:120572529 | chr1:39775242 | ENST00000289893 | 0 | 64 | 4769_4792 | 0 | 5939.0 | Repeat | Note=LRR 18 | |
| Tgene | MACF1 | chr1:120572529 | chr1:39775242 | ENST00000289893 | 0 | 64 | 4800_4904 | 0 | 5939.0 | Repeat | Note=Spectrin 4 | |
| Tgene | MACF1 | chr1:120572529 | chr1:39775242 | ENST00000289893 | 0 | 64 | 4909_5012 | 0 | 5939.0 | Repeat | Note=Spectrin 5 | |
| Tgene | MACF1 | chr1:120572529 | chr1:39775242 | ENST00000289893 | 0 | 64 | 5051_5076 | 0 | 5939.0 | Repeat | Note=LRR 19 | |
| Tgene | MACF1 | chr1:120572529 | chr1:39775242 | ENST00000289893 | 0 | 64 | 5172_5194 | 0 | 5939.0 | Repeat | Note=LRR 20 | |
| Tgene | MACF1 | chr1:120572529 | chr1:39775242 | ENST00000289893 | 0 | 64 | 5236_5341 | 0 | 5939.0 | Repeat | Note=Spectrin 6 | |
| Tgene | MACF1 | chr1:120572529 | chr1:39775242 | ENST00000289893 | 0 | 64 | 5281_5304 | 0 | 5939.0 | Repeat | Note=LRR 21 | |
| Tgene | MACF1 | chr1:120572529 | chr1:39775242 | ENST00000289893 | 0 | 64 | 5348_5450 | 0 | 5939.0 | Repeat | Note=Spectrin 7 | |
| Tgene | MACF1 | chr1:120572529 | chr1:39775242 | ENST00000289893 | 0 | 64 | 5455_5557 | 0 | 5939.0 | Repeat | Note=Spectrin 8 | |
| Tgene | MACF1 | chr1:120572529 | chr1:39775242 | ENST00000289893 | 0 | 64 | 5695_5719 | 0 | 5939.0 | Repeat | Note=LRR 22 | |
| Tgene | MACF1 | chr1:120572529 | chr1:39775242 | ENST00000289893 | 0 | 64 | 5783_5885 | 0 | 5939.0 | Repeat | Note=Spectrin 9 | |
| Tgene | MACF1 | chr1:120572529 | chr1:39775242 | ENST00000289893 | 0 | 64 | 5804_5828 | 0 | 5939.0 | Repeat | Note=LRR 23 | |
| Tgene | MACF1 | chr1:120572529 | chr1:39775242 | ENST00000289893 | 0 | 64 | 6005_6110 | 0 | 5939.0 | Repeat | Note=Spectrin 10 | |
| Tgene | MACF1 | chr1:120572529 | chr1:39775242 | ENST00000289893 | 0 | 64 | 6115_6219 | 0 | 5939.0 | Repeat | Note=Spectrin 11 | |
| Tgene | MACF1 | chr1:120572529 | chr1:39775242 | ENST00000289893 | 0 | 64 | 6225_6328 | 0 | 5939.0 | Repeat | Note=Spectrin 12 | |
| Tgene | MACF1 | chr1:120572529 | chr1:39775242 | ENST00000289893 | 0 | 64 | 6333_6439 | 0 | 5939.0 | Repeat | Note=Spectrin 13 | |
| Tgene | MACF1 | chr1:120572529 | chr1:39775242 | ENST00000289893 | 0 | 64 | 6443_6547 | 0 | 5939.0 | Repeat | Note=Spectrin 14 | |
| Tgene | MACF1 | chr1:120572529 | chr1:39775242 | ENST00000289893 | 0 | 64 | 6496_6519 | 0 | 5939.0 | Repeat | Note=LRR 24 | |
| Tgene | MACF1 | chr1:120572529 | chr1:39775242 | ENST00000289893 | 0 | 64 | 6552_6658 | 0 | 5939.0 | Repeat | Note=Spectrin 15 | |
| Tgene | MACF1 | chr1:120572529 | chr1:39775242 | ENST00000289893 | 0 | 64 | 6665_6766 | 0 | 5939.0 | Repeat | Note=Spectrin 16 | |
| Tgene | MACF1 | chr1:120572529 | chr1:39775242 | ENST00000289893 | 0 | 64 | 6771_6874 | 0 | 5939.0 | Repeat | Note=Spectrin 17 | |
| Tgene | MACF1 | chr1:120572529 | chr1:39775242 | ENST00000361689 | 21 | 93 | 1050_1073 | 934.6666666666666 | 5431.0 | Repeat | Note=LRR 5 | |
| Tgene | MACF1 | chr1:120572529 | chr1:39775242 | ENST00000361689 | 21 | 93 | 1128_1154 | 934.6666666666666 | 5431.0 | Repeat | Note=LRR 6 | |
| Tgene | MACF1 | chr1:120572529 | chr1:39775242 | ENST00000361689 | 21 | 93 | 1187_1210 | 934.6666666666666 | 5431.0 | Repeat | Note=LRR 7 | |
| Tgene | MACF1 | chr1:120572529 | chr1:39775242 | ENST00000361689 | 21 | 93 | 1257_1282 | 934.6666666666666 | 5431.0 | Repeat | Note=LRR 8 | |
| Tgene | MACF1 | chr1:120572529 | chr1:39775242 | ENST00000361689 | 21 | 93 | 1577_1621 | 934.6666666666666 | 5431.0 | Repeat | Note=Plectin 1 | |
| Tgene | MACF1 | chr1:120572529 | chr1:39775242 | ENST00000361689 | 21 | 93 | 1654_1696 | 934.6666666666666 | 5431.0 | Repeat | Note=Plectin 2 | |
| Tgene | MACF1 | chr1:120572529 | chr1:39775242 | ENST00000361689 | 21 | 93 | 1769_1809 | 934.6666666666666 | 5431.0 | Repeat | Note=Plectin 3 | |
| Tgene | MACF1 | chr1:120572529 | chr1:39775242 | ENST00000361689 | 21 | 93 | 1811_1848 | 934.6666666666666 | 5431.0 | Repeat | Note=Plectin 4 | |
| Tgene | MACF1 | chr1:120572529 | chr1:39775242 | ENST00000361689 | 21 | 93 | 1855_1886 | 934.6666666666666 | 5431.0 | Repeat | Note=Plectin 5 | |
| Tgene | MACF1 | chr1:120572529 | chr1:39775242 | ENST00000361689 | 21 | 93 | 2290_2332 | 934.6666666666666 | 5431.0 | Repeat | Note=Plectin 6 | |
| Tgene | MACF1 | chr1:120572529 | chr1:39775242 | ENST00000361689 | 21 | 93 | 2367_2410 | 934.6666666666666 | 5431.0 | Repeat | Note=Plectin 7 | |
| Tgene | MACF1 | chr1:120572529 | chr1:39775242 | ENST00000361689 | 21 | 93 | 2411_2437 | 934.6666666666666 | 5431.0 | Repeat | Note=Plectin 8 | |
| Tgene | MACF1 | chr1:120572529 | chr1:39775242 | ENST00000361689 | 21 | 93 | 2501_2543 | 934.6666666666666 | 5431.0 | Repeat | Note=Plectin 9 | |
| Tgene | MACF1 | chr1:120572529 | chr1:39775242 | ENST00000361689 | 21 | 93 | 2581_2612 | 934.6666666666666 | 5431.0 | Repeat | Note=Plectin 10 | |
| Tgene | MACF1 | chr1:120572529 | chr1:39775242 | ENST00000361689 | 21 | 93 | 2686_2730 | 934.6666666666666 | 5431.0 | Repeat | Note=Plectin 11 | |
| Tgene | MACF1 | chr1:120572529 | chr1:39775242 | ENST00000361689 | 21 | 93 | 3239_3262 | 934.6666666666666 | 5431.0 | Repeat | Note=LRR 9 | |
| Tgene | MACF1 | chr1:120572529 | chr1:39775242 | ENST00000361689 | 21 | 93 | 3264_3283 | 934.6666666666666 | 5431.0 | Repeat | Note=LRR 10 | |
| Tgene | MACF1 | chr1:120572529 | chr1:39775242 | ENST00000361689 | 21 | 93 | 3646_3669 | 934.6666666666666 | 5431.0 | Repeat | Note=LRR 11 | |
| Tgene | MACF1 | chr1:120572529 | chr1:39775242 | ENST00000361689 | 21 | 93 | 3696_3720 | 934.6666666666666 | 5431.0 | Repeat | Note=LRR 12 | |
| Tgene | MACF1 | chr1:120572529 | chr1:39775242 | ENST00000361689 | 21 | 93 | 3883_3957 | 934.6666666666666 | 5431.0 | Repeat | Note=Spectrin 1 | |
| Tgene | MACF1 | chr1:120572529 | chr1:39775242 | ENST00000361689 | 21 | 93 | 3936_3958 | 934.6666666666666 | 5431.0 | Repeat | Note=LRR 13 | |
| Tgene | MACF1 | chr1:120572529 | chr1:39775242 | ENST00000361689 | 21 | 93 | 4000_4108 | 934.6666666666666 | 5431.0 | Repeat | Note=Spectrin 2 | |
| Tgene | MACF1 | chr1:120572529 | chr1:39775242 | ENST00000361689 | 21 | 93 | 4125_4150 | 934.6666666666666 | 5431.0 | Repeat | Note=LRR 14 | |
| Tgene | MACF1 | chr1:120572529 | chr1:39775242 | ENST00000361689 | 21 | 93 | 4261_4287 | 934.6666666666666 | 5431.0 | Repeat | Note=LRR 15 | |
| Tgene | MACF1 | chr1:120572529 | chr1:39775242 | ENST00000361689 | 21 | 93 | 4466_4574 | 934.6666666666666 | 5431.0 | Repeat | Note=Spectrin 3 | |
| Tgene | MACF1 | chr1:120572529 | chr1:39775242 | ENST00000361689 | 21 | 93 | 4511_4534 | 934.6666666666666 | 5431.0 | Repeat | Note=LRR 16 | |
| Tgene | MACF1 | chr1:120572529 | chr1:39775242 | ENST00000361689 | 21 | 93 | 4601_4624 | 934.6666666666666 | 5431.0 | Repeat | Note=LRR 17 | |
| Tgene | MACF1 | chr1:120572529 | chr1:39775242 | ENST00000361689 | 21 | 93 | 4769_4792 | 934.6666666666666 | 5431.0 | Repeat | Note=LRR 18 | |
| Tgene | MACF1 | chr1:120572529 | chr1:39775242 | ENST00000361689 | 21 | 93 | 4800_4904 | 934.6666666666666 | 5431.0 | Repeat | Note=Spectrin 4 | |
| Tgene | MACF1 | chr1:120572529 | chr1:39775242 | ENST00000361689 | 21 | 93 | 4909_5012 | 934.6666666666666 | 5431.0 | Repeat | Note=Spectrin 5 | |
| Tgene | MACF1 | chr1:120572529 | chr1:39775242 | ENST00000361689 | 21 | 93 | 5051_5076 | 934.6666666666666 | 5431.0 | Repeat | Note=LRR 19 | |
| Tgene | MACF1 | chr1:120572529 | chr1:39775242 | ENST00000361689 | 21 | 93 | 5172_5194 | 934.6666666666666 | 5431.0 | Repeat | Note=LRR 20 | |
| Tgene | MACF1 | chr1:120572529 | chr1:39775242 | ENST00000361689 | 21 | 93 | 5236_5341 | 934.6666666666666 | 5431.0 | Repeat | Note=Spectrin 6 | |
| Tgene | MACF1 | chr1:120572529 | chr1:39775242 | ENST00000361689 | 21 | 93 | 5281_5304 | 934.6666666666666 | 5431.0 | Repeat | Note=LRR 21 | |
| Tgene | MACF1 | chr1:120572529 | chr1:39775242 | ENST00000361689 | 21 | 93 | 5348_5450 | 934.6666666666666 | 5431.0 | Repeat | Note=Spectrin 7 | |
| Tgene | MACF1 | chr1:120572529 | chr1:39775242 | ENST00000361689 | 21 | 93 | 5455_5557 | 934.6666666666666 | 5431.0 | Repeat | Note=Spectrin 8 | |
| Tgene | MACF1 | chr1:120572529 | chr1:39775242 | ENST00000361689 | 21 | 93 | 5695_5719 | 934.6666666666666 | 5431.0 | Repeat | Note=LRR 22 | |
| Tgene | MACF1 | chr1:120572529 | chr1:39775242 | ENST00000361689 | 21 | 93 | 5783_5885 | 934.6666666666666 | 5431.0 | Repeat | Note=Spectrin 9 | |
| Tgene | MACF1 | chr1:120572529 | chr1:39775242 | ENST00000361689 | 21 | 93 | 5804_5828 | 934.6666666666666 | 5431.0 | Repeat | Note=LRR 23 | |
| Tgene | MACF1 | chr1:120572529 | chr1:39775242 | ENST00000361689 | 21 | 93 | 6005_6110 | 934.6666666666666 | 5431.0 | Repeat | Note=Spectrin 10 | |
| Tgene | MACF1 | chr1:120572529 | chr1:39775242 | ENST00000361689 | 21 | 93 | 6115_6219 | 934.6666666666666 | 5431.0 | Repeat | Note=Spectrin 11 | |
| Tgene | MACF1 | chr1:120572529 | chr1:39775242 | ENST00000361689 | 21 | 93 | 6225_6328 | 934.6666666666666 | 5431.0 | Repeat | Note=Spectrin 12 | |
| Tgene | MACF1 | chr1:120572529 | chr1:39775242 | ENST00000361689 | 21 | 93 | 6333_6439 | 934.6666666666666 | 5431.0 | Repeat | Note=Spectrin 13 | |
| Tgene | MACF1 | chr1:120572529 | chr1:39775242 | ENST00000361689 | 21 | 93 | 6443_6547 | 934.6666666666666 | 5431.0 | Repeat | Note=Spectrin 14 | |
| Tgene | MACF1 | chr1:120572529 | chr1:39775242 | ENST00000361689 | 21 | 93 | 6496_6519 | 934.6666666666666 | 5431.0 | Repeat | Note=LRR 24 | |
| Tgene | MACF1 | chr1:120572529 | chr1:39775242 | ENST00000361689 | 21 | 93 | 6552_6658 | 934.6666666666666 | 5431.0 | Repeat | Note=Spectrin 15 | |
| Tgene | MACF1 | chr1:120572529 | chr1:39775242 | ENST00000361689 | 21 | 93 | 6665_6766 | 934.6666666666666 | 5431.0 | Repeat | Note=Spectrin 16 | |
| Tgene | MACF1 | chr1:120572529 | chr1:39775242 | ENST00000361689 | 21 | 93 | 6771_6874 | 934.6666666666666 | 5431.0 | Repeat | Note=Spectrin 17 | |
| Tgene | MACF1 | chr1:120572529 | chr1:39775242 | ENST00000372915 | 21 | 97 | 1050_1073 | 934.6666666666666 | 7389.0 | Repeat | Note=LRR 5 | |
| Tgene | MACF1 | chr1:120572529 | chr1:39775242 | ENST00000372915 | 21 | 97 | 1128_1154 | 934.6666666666666 | 7389.0 | Repeat | Note=LRR 6 | |
| Tgene | MACF1 | chr1:120572529 | chr1:39775242 | ENST00000372915 | 21 | 97 | 1187_1210 | 934.6666666666666 | 7389.0 | Repeat | Note=LRR 7 | |
| Tgene | MACF1 | chr1:120572529 | chr1:39775242 | ENST00000372915 | 21 | 97 | 1257_1282 | 934.6666666666666 | 7389.0 | Repeat | Note=LRR 8 | |
| Tgene | MACF1 | chr1:120572529 | chr1:39775242 | ENST00000372915 | 21 | 97 | 1577_1621 | 934.6666666666666 | 7389.0 | Repeat | Note=Plectin 1 | |
| Tgene | MACF1 | chr1:120572529 | chr1:39775242 | ENST00000372915 | 21 | 97 | 1654_1696 | 934.6666666666666 | 7389.0 | Repeat | Note=Plectin 2 | |
| Tgene | MACF1 | chr1:120572529 | chr1:39775242 | ENST00000372915 | 21 | 97 | 1769_1809 | 934.6666666666666 | 7389.0 | Repeat | Note=Plectin 3 | |
| Tgene | MACF1 | chr1:120572529 | chr1:39775242 | ENST00000372915 | 21 | 97 | 1811_1848 | 934.6666666666666 | 7389.0 | Repeat | Note=Plectin 4 | |
| Tgene | MACF1 | chr1:120572529 | chr1:39775242 | ENST00000372915 | 21 | 97 | 1855_1886 | 934.6666666666666 | 7389.0 | Repeat | Note=Plectin 5 | |
| Tgene | MACF1 | chr1:120572529 | chr1:39775242 | ENST00000372915 | 21 | 97 | 2290_2332 | 934.6666666666666 | 7389.0 | Repeat | Note=Plectin 6 | |
| Tgene | MACF1 | chr1:120572529 | chr1:39775242 | ENST00000372915 | 21 | 97 | 2367_2410 | 934.6666666666666 | 7389.0 | Repeat | Note=Plectin 7 | |
| Tgene | MACF1 | chr1:120572529 | chr1:39775242 | ENST00000372915 | 21 | 97 | 2411_2437 | 934.6666666666666 | 7389.0 | Repeat | Note=Plectin 8 | |
| Tgene | MACF1 | chr1:120572529 | chr1:39775242 | ENST00000372915 | 21 | 97 | 2501_2543 | 934.6666666666666 | 7389.0 | Repeat | Note=Plectin 9 | |
| Tgene | MACF1 | chr1:120572529 | chr1:39775242 | ENST00000372915 | 21 | 97 | 2581_2612 | 934.6666666666666 | 7389.0 | Repeat | Note=Plectin 10 | |
| Tgene | MACF1 | chr1:120572529 | chr1:39775242 | ENST00000372915 | 21 | 97 | 2686_2730 | 934.6666666666666 | 7389.0 | Repeat | Note=Plectin 11 | |
| Tgene | MACF1 | chr1:120572529 | chr1:39775242 | ENST00000372915 | 21 | 97 | 3239_3262 | 934.6666666666666 | 7389.0 | Repeat | Note=LRR 9 | |
| Tgene | MACF1 | chr1:120572529 | chr1:39775242 | ENST00000372915 | 21 | 97 | 3264_3283 | 934.6666666666666 | 7389.0 | Repeat | Note=LRR 10 | |
| Tgene | MACF1 | chr1:120572529 | chr1:39775242 | ENST00000372915 | 21 | 97 | 3646_3669 | 934.6666666666666 | 7389.0 | Repeat | Note=LRR 11 | |
| Tgene | MACF1 | chr1:120572529 | chr1:39775242 | ENST00000372915 | 21 | 97 | 3696_3720 | 934.6666666666666 | 7389.0 | Repeat | Note=LRR 12 | |
| Tgene | MACF1 | chr1:120572529 | chr1:39775242 | ENST00000372915 | 21 | 97 | 3883_3957 | 934.6666666666666 | 7389.0 | Repeat | Note=Spectrin 1 | |
| Tgene | MACF1 | chr1:120572529 | chr1:39775242 | ENST00000372915 | 21 | 97 | 3936_3958 | 934.6666666666666 | 7389.0 | Repeat | Note=LRR 13 | |
| Tgene | MACF1 | chr1:120572529 | chr1:39775242 | ENST00000372915 | 21 | 97 | 4000_4108 | 934.6666666666666 | 7389.0 | Repeat | Note=Spectrin 2 | |
| Tgene | MACF1 | chr1:120572529 | chr1:39775242 | ENST00000372915 | 21 | 97 | 4125_4150 | 934.6666666666666 | 7389.0 | Repeat | Note=LRR 14 | |
| Tgene | MACF1 | chr1:120572529 | chr1:39775242 | ENST00000372915 | 21 | 97 | 4261_4287 | 934.6666666666666 | 7389.0 | Repeat | Note=LRR 15 | |
| Tgene | MACF1 | chr1:120572529 | chr1:39775242 | ENST00000372915 | 21 | 97 | 4466_4574 | 934.6666666666666 | 7389.0 | Repeat | Note=Spectrin 3 | |
| Tgene | MACF1 | chr1:120572529 | chr1:39775242 | ENST00000372915 | 21 | 97 | 4511_4534 | 934.6666666666666 | 7389.0 | Repeat | Note=LRR 16 | |
| Tgene | MACF1 | chr1:120572529 | chr1:39775242 | ENST00000372915 | 21 | 97 | 4601_4624 | 934.6666666666666 | 7389.0 | Repeat | Note=LRR 17 | |
| Tgene | MACF1 | chr1:120572529 | chr1:39775242 | ENST00000372915 | 21 | 97 | 4769_4792 | 934.6666666666666 | 7389.0 | Repeat | Note=LRR 18 | |
| Tgene | MACF1 | chr1:120572529 | chr1:39775242 | ENST00000372915 | 21 | 97 | 4800_4904 | 934.6666666666666 | 7389.0 | Repeat | Note=Spectrin 4 | |
| Tgene | MACF1 | chr1:120572529 | chr1:39775242 | ENST00000372915 | 21 | 97 | 4909_5012 | 934.6666666666666 | 7389.0 | Repeat | Note=Spectrin 5 | |
| Tgene | MACF1 | chr1:120572529 | chr1:39775242 | ENST00000372915 | 21 | 97 | 5051_5076 | 934.6666666666666 | 7389.0 | Repeat | Note=LRR 19 | |
| Tgene | MACF1 | chr1:120572529 | chr1:39775242 | ENST00000372915 | 21 | 97 | 5172_5194 | 934.6666666666666 | 7389.0 | Repeat | Note=LRR 20 | |
| Tgene | MACF1 | chr1:120572529 | chr1:39775242 | ENST00000372915 | 21 | 97 | 5236_5341 | 934.6666666666666 | 7389.0 | Repeat | Note=Spectrin 6 | |
| Tgene | MACF1 | chr1:120572529 | chr1:39775242 | ENST00000372915 | 21 | 97 | 5281_5304 | 934.6666666666666 | 7389.0 | Repeat | Note=LRR 21 | |
| Tgene | MACF1 | chr1:120572529 | chr1:39775242 | ENST00000372915 | 21 | 97 | 5348_5450 | 934.6666666666666 | 7389.0 | Repeat | Note=Spectrin 7 | |
| Tgene | MACF1 | chr1:120572529 | chr1:39775242 | ENST00000372915 | 21 | 97 | 5455_5557 | 934.6666666666666 | 7389.0 | Repeat | Note=Spectrin 8 | |
| Tgene | MACF1 | chr1:120572529 | chr1:39775242 | ENST00000372915 | 21 | 97 | 5695_5719 | 934.6666666666666 | 7389.0 | Repeat | Note=LRR 22 | |
| Tgene | MACF1 | chr1:120572529 | chr1:39775242 | ENST00000372915 | 21 | 97 | 5783_5885 | 934.6666666666666 | 7389.0 | Repeat | Note=Spectrin 9 | |
| Tgene | MACF1 | chr1:120572529 | chr1:39775242 | ENST00000372915 | 21 | 97 | 5804_5828 | 934.6666666666666 | 7389.0 | Repeat | Note=LRR 23 | |
| Tgene | MACF1 | chr1:120572529 | chr1:39775242 | ENST00000372915 | 21 | 97 | 6005_6110 | 934.6666666666666 | 7389.0 | Repeat | Note=Spectrin 10 | |
| Tgene | MACF1 | chr1:120572529 | chr1:39775242 | ENST00000372915 | 21 | 97 | 6115_6219 | 934.6666666666666 | 7389.0 | Repeat | Note=Spectrin 11 | |
| Tgene | MACF1 | chr1:120572529 | chr1:39775242 | ENST00000372915 | 21 | 97 | 6225_6328 | 934.6666666666666 | 7389.0 | Repeat | Note=Spectrin 12 | |
| Tgene | MACF1 | chr1:120572529 | chr1:39775242 | ENST00000372915 | 21 | 97 | 6333_6439 | 934.6666666666666 | 7389.0 | Repeat | Note=Spectrin 13 | |
| Tgene | MACF1 | chr1:120572529 | chr1:39775242 | ENST00000372915 | 21 | 97 | 6443_6547 | 934.6666666666666 | 7389.0 | Repeat | Note=Spectrin 14 | |
| Tgene | MACF1 | chr1:120572529 | chr1:39775242 | ENST00000372915 | 21 | 97 | 6496_6519 | 934.6666666666666 | 7389.0 | Repeat | Note=LRR 24 | |
| Tgene | MACF1 | chr1:120572529 | chr1:39775242 | ENST00000372915 | 21 | 97 | 6552_6658 | 934.6666666666666 | 7389.0 | Repeat | Note=Spectrin 15 | |
| Tgene | MACF1 | chr1:120572529 | chr1:39775242 | ENST00000372915 | 21 | 97 | 6665_6766 | 934.6666666666666 | 7389.0 | Repeat | Note=Spectrin 16 | |
| Tgene | MACF1 | chr1:120572529 | chr1:39775242 | ENST00000372915 | 21 | 97 | 6771_6874 | 934.6666666666666 | 7389.0 | Repeat | Note=Spectrin 17 | |
| Tgene | MACF1 | chr1:120572529 | chr1:39775242 | ENST00000545844 | 22 | 94 | 1050_1073 | 934.6666666666666 | 5431.0 | Repeat | Note=LRR 5 | |
| Tgene | MACF1 | chr1:120572529 | chr1:39775242 | ENST00000545844 | 22 | 94 | 1128_1154 | 934.6666666666666 | 5431.0 | Repeat | Note=LRR 6 | |
| Tgene | MACF1 | chr1:120572529 | chr1:39775242 | ENST00000545844 | 22 | 94 | 1187_1210 | 934.6666666666666 | 5431.0 | Repeat | Note=LRR 7 | |
| Tgene | MACF1 | chr1:120572529 | chr1:39775242 | ENST00000545844 | 22 | 94 | 1257_1282 | 934.6666666666666 | 5431.0 | Repeat | Note=LRR 8 | |
| Tgene | MACF1 | chr1:120572529 | chr1:39775242 | ENST00000545844 | 22 | 94 | 1577_1621 | 934.6666666666666 | 5431.0 | Repeat | Note=Plectin 1 | |
| Tgene | MACF1 | chr1:120572529 | chr1:39775242 | ENST00000545844 | 22 | 94 | 1654_1696 | 934.6666666666666 | 5431.0 | Repeat | Note=Plectin 2 | |
| Tgene | MACF1 | chr1:120572529 | chr1:39775242 | ENST00000545844 | 22 | 94 | 1769_1809 | 934.6666666666666 | 5431.0 | Repeat | Note=Plectin 3 | |
| Tgene | MACF1 | chr1:120572529 | chr1:39775242 | ENST00000545844 | 22 | 94 | 1811_1848 | 934.6666666666666 | 5431.0 | Repeat | Note=Plectin 4 | |
| Tgene | MACF1 | chr1:120572529 | chr1:39775242 | ENST00000545844 | 22 | 94 | 1855_1886 | 934.6666666666666 | 5431.0 | Repeat | Note=Plectin 5 | |
| Tgene | MACF1 | chr1:120572529 | chr1:39775242 | ENST00000545844 | 22 | 94 | 2290_2332 | 934.6666666666666 | 5431.0 | Repeat | Note=Plectin 6 | |
| Tgene | MACF1 | chr1:120572529 | chr1:39775242 | ENST00000545844 | 22 | 94 | 2367_2410 | 934.6666666666666 | 5431.0 | Repeat | Note=Plectin 7 | |
| Tgene | MACF1 | chr1:120572529 | chr1:39775242 | ENST00000545844 | 22 | 94 | 2411_2437 | 934.6666666666666 | 5431.0 | Repeat | Note=Plectin 8 | |
| Tgene | MACF1 | chr1:120572529 | chr1:39775242 | ENST00000545844 | 22 | 94 | 2501_2543 | 934.6666666666666 | 5431.0 | Repeat | Note=Plectin 9 | |
| Tgene | MACF1 | chr1:120572529 | chr1:39775242 | ENST00000545844 | 22 | 94 | 2581_2612 | 934.6666666666666 | 5431.0 | Repeat | Note=Plectin 10 | |
| Tgene | MACF1 | chr1:120572529 | chr1:39775242 | ENST00000545844 | 22 | 94 | 2686_2730 | 934.6666666666666 | 5431.0 | Repeat | Note=Plectin 11 | |
| Tgene | MACF1 | chr1:120572529 | chr1:39775242 | ENST00000545844 | 22 | 94 | 3239_3262 | 934.6666666666666 | 5431.0 | Repeat | Note=LRR 9 | |
| Tgene | MACF1 | chr1:120572529 | chr1:39775242 | ENST00000545844 | 22 | 94 | 3264_3283 | 934.6666666666666 | 5431.0 | Repeat | Note=LRR 10 | |
| Tgene | MACF1 | chr1:120572529 | chr1:39775242 | ENST00000545844 | 22 | 94 | 3646_3669 | 934.6666666666666 | 5431.0 | Repeat | Note=LRR 11 | |
| Tgene | MACF1 | chr1:120572529 | chr1:39775242 | ENST00000545844 | 22 | 94 | 3696_3720 | 934.6666666666666 | 5431.0 | Repeat | Note=LRR 12 | |
| Tgene | MACF1 | chr1:120572529 | chr1:39775242 | ENST00000545844 | 22 | 94 | 3883_3957 | 934.6666666666666 | 5431.0 | Repeat | Note=Spectrin 1 | |
| Tgene | MACF1 | chr1:120572529 | chr1:39775242 | ENST00000545844 | 22 | 94 | 3936_3958 | 934.6666666666666 | 5431.0 | Repeat | Note=LRR 13 | |
| Tgene | MACF1 | chr1:120572529 | chr1:39775242 | ENST00000545844 | 22 | 94 | 4000_4108 | 934.6666666666666 | 5431.0 | Repeat | Note=Spectrin 2 | |
| Tgene | MACF1 | chr1:120572529 | chr1:39775242 | ENST00000545844 | 22 | 94 | 4125_4150 | 934.6666666666666 | 5431.0 | Repeat | Note=LRR 14 | |
| Tgene | MACF1 | chr1:120572529 | chr1:39775242 | ENST00000545844 | 22 | 94 | 4261_4287 | 934.6666666666666 | 5431.0 | Repeat | Note=LRR 15 | |
| Tgene | MACF1 | chr1:120572529 | chr1:39775242 | ENST00000545844 | 22 | 94 | 4466_4574 | 934.6666666666666 | 5431.0 | Repeat | Note=Spectrin 3 | |
| Tgene | MACF1 | chr1:120572529 | chr1:39775242 | ENST00000545844 | 22 | 94 | 4511_4534 | 934.6666666666666 | 5431.0 | Repeat | Note=LRR 16 | |
| Tgene | MACF1 | chr1:120572529 | chr1:39775242 | ENST00000545844 | 22 | 94 | 4601_4624 | 934.6666666666666 | 5431.0 | Repeat | Note=LRR 17 | |
| Tgene | MACF1 | chr1:120572529 | chr1:39775242 | ENST00000545844 | 22 | 94 | 4769_4792 | 934.6666666666666 | 5431.0 | Repeat | Note=LRR 18 | |
| Tgene | MACF1 | chr1:120572529 | chr1:39775242 | ENST00000545844 | 22 | 94 | 4800_4904 | 934.6666666666666 | 5431.0 | Repeat | Note=Spectrin 4 | |
| Tgene | MACF1 | chr1:120572529 | chr1:39775242 | ENST00000545844 | 22 | 94 | 4909_5012 | 934.6666666666666 | 5431.0 | Repeat | Note=Spectrin 5 | |
| Tgene | MACF1 | chr1:120572529 | chr1:39775242 | ENST00000545844 | 22 | 94 | 5051_5076 | 934.6666666666666 | 5431.0 | Repeat | Note=LRR 19 | |
| Tgene | MACF1 | chr1:120572529 | chr1:39775242 | ENST00000545844 | 22 | 94 | 5172_5194 | 934.6666666666666 | 5431.0 | Repeat | Note=LRR 20 | |
| Tgene | MACF1 | chr1:120572529 | chr1:39775242 | ENST00000545844 | 22 | 94 | 5236_5341 | 934.6666666666666 | 5431.0 | Repeat | Note=Spectrin 6 | |
| Tgene | MACF1 | chr1:120572529 | chr1:39775242 | ENST00000545844 | 22 | 94 | 5281_5304 | 934.6666666666666 | 5431.0 | Repeat | Note=LRR 21 | |
| Tgene | MACF1 | chr1:120572529 | chr1:39775242 | ENST00000545844 | 22 | 94 | 5348_5450 | 934.6666666666666 | 5431.0 | Repeat | Note=Spectrin 7 | |
| Tgene | MACF1 | chr1:120572529 | chr1:39775242 | ENST00000545844 | 22 | 94 | 5455_5557 | 934.6666666666666 | 5431.0 | Repeat | Note=Spectrin 8 | |
| Tgene | MACF1 | chr1:120572529 | chr1:39775242 | ENST00000545844 | 22 | 94 | 5695_5719 | 934.6666666666666 | 5431.0 | Repeat | Note=LRR 22 | |
| Tgene | MACF1 | chr1:120572529 | chr1:39775242 | ENST00000545844 | 22 | 94 | 5783_5885 | 934.6666666666666 | 5431.0 | Repeat | Note=Spectrin 9 | |
| Tgene | MACF1 | chr1:120572529 | chr1:39775242 | ENST00000545844 | 22 | 94 | 5804_5828 | 934.6666666666666 | 5431.0 | Repeat | Note=LRR 23 | |
| Tgene | MACF1 | chr1:120572529 | chr1:39775242 | ENST00000545844 | 22 | 94 | 6005_6110 | 934.6666666666666 | 5431.0 | Repeat | Note=Spectrin 10 | |
| Tgene | MACF1 | chr1:120572529 | chr1:39775242 | ENST00000545844 | 22 | 94 | 6115_6219 | 934.6666666666666 | 5431.0 | Repeat | Note=Spectrin 11 | |
| Tgene | MACF1 | chr1:120572529 | chr1:39775242 | ENST00000545844 | 22 | 94 | 6225_6328 | 934.6666666666666 | 5431.0 | Repeat | Note=Spectrin 12 | |
| Tgene | MACF1 | chr1:120572529 | chr1:39775242 | ENST00000545844 | 22 | 94 | 6333_6439 | 934.6666666666666 | 5431.0 | Repeat | Note=Spectrin 13 | |
| Tgene | MACF1 | chr1:120572529 | chr1:39775242 | ENST00000545844 | 22 | 94 | 6443_6547 | 934.6666666666666 | 5431.0 | Repeat | Note=Spectrin 14 | |
| Tgene | MACF1 | chr1:120572529 | chr1:39775242 | ENST00000545844 | 22 | 94 | 6496_6519 | 934.6666666666666 | 5431.0 | Repeat | Note=LRR 24 | |
| Tgene | MACF1 | chr1:120572529 | chr1:39775242 | ENST00000545844 | 22 | 94 | 6552_6658 | 934.6666666666666 | 5431.0 | Repeat | Note=Spectrin 15 | |
| Tgene | MACF1 | chr1:120572529 | chr1:39775242 | ENST00000545844 | 22 | 94 | 6665_6766 | 934.6666666666666 | 5431.0 | Repeat | Note=Spectrin 16 | |
| Tgene | MACF1 | chr1:120572529 | chr1:39775242 | ENST00000545844 | 22 | 94 | 6771_6874 | 934.6666666666666 | 5431.0 | Repeat | Note=Spectrin 17 |
| - Not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | NOTCH2 | chr1:120572529 | chr1:39775242 | ENST00000256646 | - | 2 | 34 | 1645_1648 | 51.666666666666664 | 2472.0 | Compositional bias | Note=Poly-Ala |
| Hgene | NOTCH2 | chr1:120572529 | chr1:39775242 | ENST00000256646 | - | 2 | 34 | 1994_1997 | 51.666666666666664 | 2472.0 | Compositional bias | Note=Poly-Leu |
| Hgene | NOTCH2 | chr1:120572529 | chr1:39775242 | ENST00000256646 | - | 2 | 34 | 2426_2429 | 51.666666666666664 | 2472.0 | Compositional bias | Note=Poly-Ser |
| Hgene | NOTCH2 | chr1:120572529 | chr1:39775242 | ENST00000256646 | - | 2 | 34 | 1025_1061 | 51.666666666666664 | 2472.0 | Domain | EGF-like 27%3B calcium-binding |
| Hgene | NOTCH2 | chr1:120572529 | chr1:39775242 | ENST00000256646 | - | 2 | 34 | 105_143 | 51.666666666666664 | 2472.0 | Domain | EGF-like 3 |
| Hgene | NOTCH2 | chr1:120572529 | chr1:39775242 | ENST00000256646 | - | 2 | 34 | 1063_1099 | 51.666666666666664 | 2472.0 | Domain | EGF-like 28 |
| Hgene | NOTCH2 | chr1:120572529 | chr1:39775242 | ENST00000256646 | - | 2 | 34 | 1101_1147 | 51.666666666666664 | 2472.0 | Domain | EGF-like 29 |
| Hgene | NOTCH2 | chr1:120572529 | chr1:39775242 | ENST00000256646 | - | 2 | 34 | 1149_1185 | 51.666666666666664 | 2472.0 | Domain | EGF-like 30%3B calcium-binding |
| Hgene | NOTCH2 | chr1:120572529 | chr1:39775242 | ENST00000256646 | - | 2 | 34 | 1187_1223 | 51.666666666666664 | 2472.0 | Domain | EGF-like 31%3B calcium-binding |
| Hgene | NOTCH2 | chr1:120572529 | chr1:39775242 | ENST00000256646 | - | 2 | 34 | 1225_1262 | 51.666666666666664 | 2472.0 | Domain | EGF-like 32%3B calcium-binding |
| Hgene | NOTCH2 | chr1:120572529 | chr1:39775242 | ENST00000256646 | - | 2 | 34 | 1264_1302 | 51.666666666666664 | 2472.0 | Domain | EGF-like 33 |
| Hgene | NOTCH2 | chr1:120572529 | chr1:39775242 | ENST00000256646 | - | 2 | 34 | 1304_1343 | 51.666666666666664 | 2472.0 | Domain | EGF-like 34 |
| Hgene | NOTCH2 | chr1:120572529 | chr1:39775242 | ENST00000256646 | - | 2 | 34 | 1374_1412 | 51.666666666666664 | 2472.0 | Domain | EGF-like 35 |
| Hgene | NOTCH2 | chr1:120572529 | chr1:39775242 | ENST00000256646 | - | 2 | 34 | 144_180 | 51.666666666666664 | 2472.0 | Domain | EGF-like 4 |
| Hgene | NOTCH2 | chr1:120572529 | chr1:39775242 | ENST00000256646 | - | 2 | 34 | 182_219 | 51.666666666666664 | 2472.0 | Domain | EGF-like 5%3B calcium-binding |
| Hgene | NOTCH2 | chr1:120572529 | chr1:39775242 | ENST00000256646 | - | 2 | 34 | 221_258 | 51.666666666666664 | 2472.0 | Domain | EGF-like 6 |
| Hgene | NOTCH2 | chr1:120572529 | chr1:39775242 | ENST00000256646 | - | 2 | 34 | 260_296 | 51.666666666666664 | 2472.0 | Domain | EGF-like 7%3B calcium-binding |
| Hgene | NOTCH2 | chr1:120572529 | chr1:39775242 | ENST00000256646 | - | 2 | 34 | 26_63 | 51.666666666666664 | 2472.0 | Domain | EGF-like 1 |
| Hgene | NOTCH2 | chr1:120572529 | chr1:39775242 | ENST00000256646 | - | 2 | 34 | 298_336 | 51.666666666666664 | 2472.0 | Domain | EGF-like 8%3B calcium-binding |
| Hgene | NOTCH2 | chr1:120572529 | chr1:39775242 | ENST00000256646 | - | 2 | 34 | 338_374 | 51.666666666666664 | 2472.0 | Domain | EGF-like 9%3B calcium-binding |
| Hgene | NOTCH2 | chr1:120572529 | chr1:39775242 | ENST00000256646 | - | 2 | 34 | 375_413 | 51.666666666666664 | 2472.0 | Domain | EGF-like 10 |
| Hgene | NOTCH2 | chr1:120572529 | chr1:39775242 | ENST00000256646 | - | 2 | 34 | 415_454 | 51.666666666666664 | 2472.0 | Domain | EGF-like 11%3B calcium-binding |
| Hgene | NOTCH2 | chr1:120572529 | chr1:39775242 | ENST00000256646 | - | 2 | 34 | 456_492 | 51.666666666666664 | 2472.0 | Domain | EGF-like 12%3B calcium-binding |
| Hgene | NOTCH2 | chr1:120572529 | chr1:39775242 | ENST00000256646 | - | 2 | 34 | 494_530 | 51.666666666666664 | 2472.0 | Domain | EGF-like 13%3B calcium-binding |
| Hgene | NOTCH2 | chr1:120572529 | chr1:39775242 | ENST00000256646 | - | 2 | 34 | 532_568 | 51.666666666666664 | 2472.0 | Domain | EGF-like 14%3B calcium-binding |
| Hgene | NOTCH2 | chr1:120572529 | chr1:39775242 | ENST00000256646 | - | 2 | 34 | 570_605 | 51.666666666666664 | 2472.0 | Domain | EGF-like 15%3B calcium-binding |
| Hgene | NOTCH2 | chr1:120572529 | chr1:39775242 | ENST00000256646 | - | 2 | 34 | 607_643 | 51.666666666666664 | 2472.0 | Domain | EGF-like 16%3B calcium-binding |
| Hgene | NOTCH2 | chr1:120572529 | chr1:39775242 | ENST00000256646 | - | 2 | 34 | 645_680 | 51.666666666666664 | 2472.0 | Domain | EGF-like 17%3B calcium-binding |
| Hgene | NOTCH2 | chr1:120572529 | chr1:39775242 | ENST00000256646 | - | 2 | 34 | 64_102 | 51.666666666666664 | 2472.0 | Domain | EGF-like 2 |
| Hgene | NOTCH2 | chr1:120572529 | chr1:39775242 | ENST00000256646 | - | 2 | 34 | 682_718 | 51.666666666666664 | 2472.0 | Domain | EGF-like 18%3B calcium-binding |
| Hgene | NOTCH2 | chr1:120572529 | chr1:39775242 | ENST00000256646 | - | 2 | 34 | 720_755 | 51.666666666666664 | 2472.0 | Domain | EGF-like 19 |
| Hgene | NOTCH2 | chr1:120572529 | chr1:39775242 | ENST00000256646 | - | 2 | 34 | 757_793 | 51.666666666666664 | 2472.0 | Domain | EGF-like 20%3B calcium-binding |
| Hgene | NOTCH2 | chr1:120572529 | chr1:39775242 | ENST00000256646 | - | 2 | 34 | 795_831 | 51.666666666666664 | 2472.0 | Domain | EGF-like 21%3B calcium-binding |
| Hgene | NOTCH2 | chr1:120572529 | chr1:39775242 | ENST00000256646 | - | 2 | 34 | 833_871 | 51.666666666666664 | 2472.0 | Domain | EGF-like 22 |
| Hgene | NOTCH2 | chr1:120572529 | chr1:39775242 | ENST00000256646 | - | 2 | 34 | 873_909 | 51.666666666666664 | 2472.0 | Domain | EGF-like 23%3B calcium-binding |
| Hgene | NOTCH2 | chr1:120572529 | chr1:39775242 | ENST00000256646 | - | 2 | 34 | 911_947 | 51.666666666666664 | 2472.0 | Domain | EGF-like 24%3B calcium-binding |
| Hgene | NOTCH2 | chr1:120572529 | chr1:39775242 | ENST00000256646 | - | 2 | 34 | 949_985 | 51.666666666666664 | 2472.0 | Domain | EGF-like 25%3B calcium-binding |
| Hgene | NOTCH2 | chr1:120572529 | chr1:39775242 | ENST00000256646 | - | 2 | 34 | 987_1023 | 51.666666666666664 | 2472.0 | Domain | EGF-like 26%3B calcium-binding |
| Hgene | NOTCH2 | chr1:120572529 | chr1:39775242 | ENST00000256646 | - | 2 | 34 | 1425_1677 | 51.666666666666664 | 2472.0 | Region | Note=Negative regulatory region (NRR) |
| Hgene | NOTCH2 | chr1:120572529 | chr1:39775242 | ENST00000256646 | - | 2 | 34 | 1425_1465 | 51.666666666666664 | 2472.0 | Repeat | Note=LNR 1 |
| Hgene | NOTCH2 | chr1:120572529 | chr1:39775242 | ENST00000256646 | - | 2 | 34 | 1466_1502 | 51.666666666666664 | 2472.0 | Repeat | Note=LNR 2 |
| Hgene | NOTCH2 | chr1:120572529 | chr1:39775242 | ENST00000256646 | - | 2 | 34 | 1503_1544 | 51.666666666666664 | 2472.0 | Repeat | Note=LNR 3 |
| Hgene | NOTCH2 | chr1:120572529 | chr1:39775242 | ENST00000256646 | - | 2 | 34 | 1827_1871 | 51.666666666666664 | 2472.0 | Repeat | Note=ANK 1 |
| Hgene | NOTCH2 | chr1:120572529 | chr1:39775242 | ENST00000256646 | - | 2 | 34 | 1876_1905 | 51.666666666666664 | 2472.0 | Repeat | Note=ANK 2 |
| Hgene | NOTCH2 | chr1:120572529 | chr1:39775242 | ENST00000256646 | - | 2 | 34 | 1909_1939 | 51.666666666666664 | 2472.0 | Repeat | Note=ANK 3 |
| Hgene | NOTCH2 | chr1:120572529 | chr1:39775242 | ENST00000256646 | - | 2 | 34 | 1943_1972 | 51.666666666666664 | 2472.0 | Repeat | Note=ANK 4 |
| Hgene | NOTCH2 | chr1:120572529 | chr1:39775242 | ENST00000256646 | - | 2 | 34 | 1976_2005 | 51.666666666666664 | 2472.0 | Repeat | Note=ANK 5 |
| Hgene | NOTCH2 | chr1:120572529 | chr1:39775242 | ENST00000256646 | - | 2 | 34 | 2009_2038 | 51.666666666666664 | 2472.0 | Repeat | Note=ANK 6 |
| Hgene | NOTCH2 | chr1:120572529 | chr1:39775242 | ENST00000256646 | - | 2 | 34 | 1699_2471 | 51.666666666666664 | 2472.0 | Topological domain | Cytoplasmic |
| Hgene | NOTCH2 | chr1:120572529 | chr1:39775242 | ENST00000256646 | - | 2 | 34 | 26_1677 | 51.666666666666664 | 2472.0 | Topological domain | Extracellular |
| Hgene | NOTCH2 | chr1:120572529 | chr1:39775242 | ENST00000256646 | - | 2 | 34 | 1678_1698 | 51.666666666666664 | 2472.0 | Transmembrane | Helical |
| Tgene | MACF1 | chr1:120572529 | chr1:39775242 | ENST00000361689 | 21 | 93 | 698_703 | 934.6666666666666 | 5431.0 | Compositional bias | Note=Poly-Glu | |
| Tgene | MACF1 | chr1:120572529 | chr1:39775242 | ENST00000372915 | 21 | 97 | 698_703 | 934.6666666666666 | 7389.0 | Compositional bias | Note=Poly-Glu | |
| Tgene | MACF1 | chr1:120572529 | chr1:39775242 | ENST00000545844 | 22 | 94 | 698_703 | 934.6666666666666 | 5431.0 | Compositional bias | Note=Poly-Glu | |
| Tgene | MACF1 | chr1:120572529 | chr1:39775242 | ENST00000361689 | 21 | 93 | 194_298 | 934.6666666666666 | 5431.0 | Domain | Calponin-homology (CH) 2 | |
| Tgene | MACF1 | chr1:120572529 | chr1:39775242 | ENST00000361689 | 21 | 93 | 78_181 | 934.6666666666666 | 5431.0 | Domain | Calponin-homology (CH) 1 | |
| Tgene | MACF1 | chr1:120572529 | chr1:39775242 | ENST00000361689 | 21 | 93 | 868_925 | 934.6666666666666 | 5431.0 | Domain | SH3 | |
| Tgene | MACF1 | chr1:120572529 | chr1:39775242 | ENST00000372915 | 21 | 97 | 194_298 | 934.6666666666666 | 7389.0 | Domain | Calponin-homology (CH) 2 | |
| Tgene | MACF1 | chr1:120572529 | chr1:39775242 | ENST00000372915 | 21 | 97 | 78_181 | 934.6666666666666 | 7389.0 | Domain | Calponin-homology (CH) 1 | |
| Tgene | MACF1 | chr1:120572529 | chr1:39775242 | ENST00000372915 | 21 | 97 | 868_925 | 934.6666666666666 | 7389.0 | Domain | SH3 | |
| Tgene | MACF1 | chr1:120572529 | chr1:39775242 | ENST00000545844 | 22 | 94 | 194_298 | 934.6666666666666 | 5431.0 | Domain | Calponin-homology (CH) 2 | |
| Tgene | MACF1 | chr1:120572529 | chr1:39775242 | ENST00000545844 | 22 | 94 | 78_181 | 934.6666666666666 | 5431.0 | Domain | Calponin-homology (CH) 1 | |
| Tgene | MACF1 | chr1:120572529 | chr1:39775242 | ENST00000545844 | 22 | 94 | 868_925 | 934.6666666666666 | 5431.0 | Domain | SH3 | |
| Tgene | MACF1 | chr1:120572529 | chr1:39775242 | ENST00000361689 | 21 | 93 | 1_295 | 934.6666666666666 | 5431.0 | Region | Note=Actin-binding | |
| Tgene | MACF1 | chr1:120572529 | chr1:39775242 | ENST00000372915 | 21 | 97 | 1_295 | 934.6666666666666 | 7389.0 | Region | Note=Actin-binding | |
| Tgene | MACF1 | chr1:120572529 | chr1:39775242 | ENST00000545844 | 22 | 94 | 1_295 | 934.6666666666666 | 5431.0 | Region | Note=Actin-binding | |
| Tgene | MACF1 | chr1:120572529 | chr1:39775242 | ENST00000361689 | 21 | 93 | 148_171 | 934.6666666666666 | 5431.0 | Repeat | Note=LRR 1 | |
| Tgene | MACF1 | chr1:120572529 | chr1:39775242 | ENST00000361689 | 21 | 93 | 240_264 | 934.6666666666666 | 5431.0 | Repeat | Note=LRR 2 | |
| Tgene | MACF1 | chr1:120572529 | chr1:39775242 | ENST00000361689 | 21 | 93 | 377_399 | 934.6666666666666 | 5431.0 | Repeat | Note=LRR 3 | |
| Tgene | MACF1 | chr1:120572529 | chr1:39775242 | ENST00000361689 | 21 | 93 | 441_464 | 934.6666666666666 | 5431.0 | Repeat | Note=LRR 4 | |
| Tgene | MACF1 | chr1:120572529 | chr1:39775242 | ENST00000372915 | 21 | 97 | 148_171 | 934.6666666666666 | 7389.0 | Repeat | Note=LRR 1 | |
| Tgene | MACF1 | chr1:120572529 | chr1:39775242 | ENST00000372915 | 21 | 97 | 240_264 | 934.6666666666666 | 7389.0 | Repeat | Note=LRR 2 | |
| Tgene | MACF1 | chr1:120572529 | chr1:39775242 | ENST00000372915 | 21 | 97 | 377_399 | 934.6666666666666 | 7389.0 | Repeat | Note=LRR 3 | |
| Tgene | MACF1 | chr1:120572529 | chr1:39775242 | ENST00000372915 | 21 | 97 | 441_464 | 934.6666666666666 | 7389.0 | Repeat | Note=LRR 4 | |
| Tgene | MACF1 | chr1:120572529 | chr1:39775242 | ENST00000545844 | 22 | 94 | 148_171 | 934.6666666666666 | 5431.0 | Repeat | Note=LRR 1 | |
| Tgene | MACF1 | chr1:120572529 | chr1:39775242 | ENST00000545844 | 22 | 94 | 240_264 | 934.6666666666666 | 5431.0 | Repeat | Note=LRR 2 | |
| Tgene | MACF1 | chr1:120572529 | chr1:39775242 | ENST00000545844 | 22 | 94 | 377_399 | 934.6666666666666 | 5431.0 | Repeat | Note=LRR 3 | |
| Tgene | MACF1 | chr1:120572529 | chr1:39775242 | ENST00000545844 | 22 | 94 | 441_464 | 934.6666666666666 | 5431.0 | Repeat | Note=LRR 4 |
Top |
Fusion Protein-Protein Interaction |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in |
| Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160) |
| Gene | PPI interactors |
| Protein-protein interactors based on sequence similarity (STRING) |
| Gene | STRING network |
| NOTCH2 | |
| MACF1 |
| - Retained interactions in fusion protein (protein functional feature from UniProt). |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost interactions due to fusion (protein functional feature from UniProt). |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
Top |
Related Drugs to NOTCH2-MACF1 |
| Drugs used for this fusion-positive patient. (Manual curation of PubMed, 04-30-2022 + MyCancerGenome) |
| Hgene | Tgene | Drug | Source | PMID |
Top |
Related Diseases to NOTCH2-MACF1 |
| Diseases that have this fusion gene. (Manual curation of PubMed, 04-30-2022 + MyCancerGenome) |
| Hgene | Tgene | Disease | Source | PMID |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
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