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Center for Computational Systems Medicine level1
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:NOTCH2NL-PDE4DIP

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: NOTCH2NL-PDE4DIP
FusionPDB ID: 59750
FusionGDB2.0 ID: 59750
HgeneTgene
Gene symbol

NOTCH2NL

PDE4DIP

Gene ID

100996763

9659

Gene namenotch 2 N-terminal like Bphosphodiesterase 4D interacting protein
SynonymsN2N|NOTCH2NL|NOTCH2NLACMYA2|MMGL
Cytomap

1q21.2

1q21.2

Type of geneprotein-codingprotein-coding
Descriptionnotch homolog 2 N-terminal-like protein BNotch homolog 2 N-terminal-like protein Anotch homolog 2 N-terminal-like proteinmyomegalincardiomyopathy-associated protein 2myomegalin/phosphodiesterase 4D interacting protein variant 8
Modification date2020031320200313
UniProtAcc

P0DPK3

.
Ensembl transtripts involved in fusion geneENST idsENST00000344859, ENST00000362074, 
ENST00000369340, ENST00000479995, 
ENST00000313431, ENST00000369345, 
ENST00000369347, ENST00000369348, 
ENST00000369349, ENST00000369351, 
ENST00000369354, ENST00000369356, 
ENST00000369359, ENST00000478649, 
ENST00000479408, ENST00000493130, 
ENST00000524974, ENST00000529945, 
ENST00000530740, ENST00000313382, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score23 X 4 X 14=128812 X 9 X 8=864
# samples 2213
** MAII scorelog2(22/1288*10)=-2.54955716458996
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(13/864*10)=-2.73251968913501
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: NOTCH2NL [Title/Abstract] AND PDE4DIP [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)NOTCH2NL(145248894)-PDE4DIP(145021167), # samples:1
Anticipated loss of major functional domain due to fusion event.NOTCH2NL-PDE4DIP seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
NOTCH2NL-PDE4DIP seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
NOTCH2NL-PDE4DIP seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
NOTCH2NL-PDE4DIP seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneNOTCH2NL

GO:0021987

cerebral cortex development

29561261|29856954|29856955

HgeneNOTCH2NL

GO:0045747

positive regulation of Notch signaling pathway

29856954|29856955

TgenePDE4DIP

GO:1903358

regulation of Golgi organization

27666745


check buttonFusion gene breakpoints across NOTCH2NL (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across PDE4DIP (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4PRADTCGA-EJ-5527NOTCH2NLchr1

145248894

+PDE4DIPchr1

145021167

-


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000362074NOTCH2NLchr1145248894+ENST00000313382PDE4DIPchr1145021167-813740013471022322
ENST00000344859NOTCH2NLchr1145248894+ENST00000313382PDE4DIPchr1145021167-813740013471022322
ENST00000369340NOTCH2NLchr1145248894+ENST00000313382PDE4DIPchr1145021167-821948240271842260

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000362074ENST00000313382NOTCH2NLchr1145248894+PDE4DIPchr1145021167-0.0078549370.992145
ENST00000344859ENST00000313382NOTCH2NLchr1145248894+PDE4DIPchr1145021167-0.0078549370.992145
ENST00000369340ENST00000313382NOTCH2NLchr1145248894+PDE4DIPchr1145021167-0.007742990.992257

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>59750_59750_1_NOTCH2NL-PDE4DIP_NOTCH2NL_chr1_145248894_ENST00000344859_PDE4DIP_chr1_145021167_ENST00000313382_length(amino acids)=2322AA_BP=89
MKQEEGRREWGSSIGTPSPCGSAQAAAAAAAEEATEKIPALRPALLWALLALWLCCATPAHALQCRDGYEPCVNEGMCVTYHNGTGYCKD
YFAEDDGEMVPRTSHTAAFLSDTKDRGPPVQSQIWRSGEKVPFVQTYSLRAFEKPPQVQTQALRDFEKHLNDLKKENFSLKLRIYFLEER
MQQKYEASREDIYKRNIELKVEVESLKRELQDKKQHLDKTWADVENLNSQNEAELRRQFEERQQETEHVYELLENKIQLLQEESRLAKNE
AARMAALVEAEKECNLELSEKLKGVTKNWEDVPGDQVKPDQYTEALAQRDKRIEELNQSLAAQERLVEQLSREKQQLLHLLEEPTSMEVQ
PMTEELLKQQKLNSHETTITQQSVSDSHLAELQEKIQQTEATNKILQEKLNEMSYELKCAQESSQKQDGTIQNLKETLKSRERETEELYQ
VIEGQNDTMAKLREMLHQSQLGQLHSSEGTSPAQQQVALLDLQSALFCSQLEIQKLQRVVRQKERQLADAKQCVQFVEAAAHESEQQKEA
SWKHNQELRKALQQLQEELQNKSQQLRAWEAEKYNEIRTQEQNIQHLNHSLSHKEQLLQEFRELLQYRDNSDKTLEANEMLLEKLRQRIH
DKAVALERAIDEKFSALEEKEKELRQLRLAVRERDHDLERLRDVLSSNEATMQSMESLLRAKGLEVEQLSTTCQNLQWLKEEMETKFSRW
QKEQESIIQQLQTSLHDRNKEVEDLSATLLCKLGPGQSEIAEELCQRLQRKERMLQDLLSDRNKQVLEHEMEIQGLLQSVSTREQESQAA
AEKLVQALMERNSELQALRQYLGGRDSLMSQAPISNQQAEVTPTGCLGKQTDQGSMQIPSRDDSTSLTAKEDVSIPRSTLGDLDTVAGLE
KELSNAKEELELMAKKERESQMELSALQSMMAVQEEELQVQAADMESLTRNIQIKEDLIKDLQMQLVDPEDIPAMERLTQEVLLLREKVA
SVESQGQEISGNRRQQLLLMLEGLVDERSRLNEALQAERQLYSSLVKFHAHPESSERDRTLQVELEGAQVLRSRLEEVLGRSLERLNRLE
TLAAIGGAAAGDDTEDTSTEFTDSIEEEAAHHSHQQLVKVALEKSLATVETQNPSFSPPSPMGGDSNRCLQEEMLHLRAEFHQHLEEKRK
AEEELKELKAQIEEAGFSSVSHIRNTMLSLCLENAELKEQMGEAMSDGWEIEEDKEKGELDNQSQPRDPGPQSAFSLPGSTQHLRSQLSQ
CKQRYQDLQEKLLLSEATVFAQANELEKYRVMLTGESLVKQDSKQIQVDLQDLGYETCGRSENEAEREETTSPECEEHNSLKEMVLMEGL
CSEQGRRGSTLASSSERKPLENQLGKQEEFRVYGKSENILVLRKDIKDLKAQLQNANKVIQNLKSRVRSLSVTSDYSSSLERPWKLRAVG
TLEGSSPHSVPDEDEGWLSDGTGAFYSPGLQAKKDLESLIQRVSQLEAQLPKNGLEEKLAEELRSASWPGKYDSLIQDQARELSYLRQKI
REGRGICYLITRHAKDTVKSFEDLLRSNDIDYYLGQSFREQLAQGSQLTERLTSKLSTKDHKSEKDQAGLEPLALRLSRELQEKEKVIEV
LQAKLDARSLTPSSSHALSDSHRSPSSTSFLSDELEACSDMDIVSEYTHYEEKKASPSHSDSIHHSSHSAVLSSKPSSTSASQGAKAESN
SNPISLPTPQNTPKEANQAHSGASTVPPASTATLLSNDLEADSSYYLNSAQPHSPPRGTIELGRILEPGYLGSSGKWDVMRPQKGSVSGD
LSSGSSVYQLNSKPTGADLLEEHLGEIRNLRQRLEESICINDRLREQLEHRLTSTARGRGSTSNFYSQGLESIPQLCNENRVLREDNRRL
QAQLSHVSREHSQETESLREALLSSRSHLQELEKELEHQKVERQQLLEDLREKQQEVLHFREERLSLQENDSRLQHKLVLLQQQCEEKQQ
LFESLQSELQIYEALYGNSKKGLKAYSLDACHQIPLSSDLSHLVAEVRALRGQLEQSIQGNNCLRLQLQQQLESGAGKASLSPSSINQNF
PASTDPGNKQLLLQDSAVSPPVRDVGMNSPALVFPSSASSTPGSETPIINRANGLGLDTSPVMKTPPKLEGDATDGSFANKHGRHVIGHI
DDYSALRQQIAEGKLLVKKIVSLVRSACSFPGLEAQGTEVLGSKGIHELRSSTSALHHALEESASLLTMFWRAALPSTHIPVLPGKVGES

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>59750_59750_2_NOTCH2NL-PDE4DIP_NOTCH2NL_chr1_145248894_ENST00000362074_PDE4DIP_chr1_145021167_ENST00000313382_length(amino acids)=2322AA_BP=89
MKQEEGRREWGSSIGTPSPCGSAQAAAAAAAEEATEKIPALRPALLWALLALWLCCATPAHALQCRDGYEPCVNEGMCVTYHNGTGYCKD
YFAEDDGEMVPRTSHTAAFLSDTKDRGPPVQSQIWRSGEKVPFVQTYSLRAFEKPPQVQTQALRDFEKHLNDLKKENFSLKLRIYFLEER
MQQKYEASREDIYKRNIELKVEVESLKRELQDKKQHLDKTWADVENLNSQNEAELRRQFEERQQETEHVYELLENKIQLLQEESRLAKNE
AARMAALVEAEKECNLELSEKLKGVTKNWEDVPGDQVKPDQYTEALAQRDKRIEELNQSLAAQERLVEQLSREKQQLLHLLEEPTSMEVQ
PMTEELLKQQKLNSHETTITQQSVSDSHLAELQEKIQQTEATNKILQEKLNEMSYELKCAQESSQKQDGTIQNLKETLKSRERETEELYQ
VIEGQNDTMAKLREMLHQSQLGQLHSSEGTSPAQQQVALLDLQSALFCSQLEIQKLQRVVRQKERQLADAKQCVQFVEAAAHESEQQKEA
SWKHNQELRKALQQLQEELQNKSQQLRAWEAEKYNEIRTQEQNIQHLNHSLSHKEQLLQEFRELLQYRDNSDKTLEANEMLLEKLRQRIH
DKAVALERAIDEKFSALEEKEKELRQLRLAVRERDHDLERLRDVLSSNEATMQSMESLLRAKGLEVEQLSTTCQNLQWLKEEMETKFSRW
QKEQESIIQQLQTSLHDRNKEVEDLSATLLCKLGPGQSEIAEELCQRLQRKERMLQDLLSDRNKQVLEHEMEIQGLLQSVSTREQESQAA
AEKLVQALMERNSELQALRQYLGGRDSLMSQAPISNQQAEVTPTGCLGKQTDQGSMQIPSRDDSTSLTAKEDVSIPRSTLGDLDTVAGLE
KELSNAKEELELMAKKERESQMELSALQSMMAVQEEELQVQAADMESLTRNIQIKEDLIKDLQMQLVDPEDIPAMERLTQEVLLLREKVA
SVESQGQEISGNRRQQLLLMLEGLVDERSRLNEALQAERQLYSSLVKFHAHPESSERDRTLQVELEGAQVLRSRLEEVLGRSLERLNRLE
TLAAIGGAAAGDDTEDTSTEFTDSIEEEAAHHSHQQLVKVALEKSLATVETQNPSFSPPSPMGGDSNRCLQEEMLHLRAEFHQHLEEKRK
AEEELKELKAQIEEAGFSSVSHIRNTMLSLCLENAELKEQMGEAMSDGWEIEEDKEKGELDNQSQPRDPGPQSAFSLPGSTQHLRSQLSQ
CKQRYQDLQEKLLLSEATVFAQANELEKYRVMLTGESLVKQDSKQIQVDLQDLGYETCGRSENEAEREETTSPECEEHNSLKEMVLMEGL
CSEQGRRGSTLASSSERKPLENQLGKQEEFRVYGKSENILVLRKDIKDLKAQLQNANKVIQNLKSRVRSLSVTSDYSSSLERPWKLRAVG
TLEGSSPHSVPDEDEGWLSDGTGAFYSPGLQAKKDLESLIQRVSQLEAQLPKNGLEEKLAEELRSASWPGKYDSLIQDQARELSYLRQKI
REGRGICYLITRHAKDTVKSFEDLLRSNDIDYYLGQSFREQLAQGSQLTERLTSKLSTKDHKSEKDQAGLEPLALRLSRELQEKEKVIEV
LQAKLDARSLTPSSSHALSDSHRSPSSTSFLSDELEACSDMDIVSEYTHYEEKKASPSHSDSIHHSSHSAVLSSKPSSTSASQGAKAESN
SNPISLPTPQNTPKEANQAHSGASTVPPASTATLLSNDLEADSSYYLNSAQPHSPPRGTIELGRILEPGYLGSSGKWDVMRPQKGSVSGD
LSSGSSVYQLNSKPTGADLLEEHLGEIRNLRQRLEESICINDRLREQLEHRLTSTARGRGSTSNFYSQGLESIPQLCNENRVLREDNRRL
QAQLSHVSREHSQETESLREALLSSRSHLQELEKELEHQKVERQQLLEDLREKQQEVLHFREERLSLQENDSRLQHKLVLLQQQCEEKQQ
LFESLQSELQIYEALYGNSKKGLKAYSLDACHQIPLSSDLSHLVAEVRALRGQLEQSIQGNNCLRLQLQQQLESGAGKASLSPSSINQNF
PASTDPGNKQLLLQDSAVSPPVRDVGMNSPALVFPSSASSTPGSETPIINRANGLGLDTSPVMKTPPKLEGDATDGSFANKHGRHVIGHI
DDYSALRQQIAEGKLLVKKIVSLVRSACSFPGLEAQGTEVLGSKGIHELRSSTSALHHALEESASLLTMFWRAALPSTHIPVLPGKVGES

--------------------------------------------------------------

>59750_59750_3_NOTCH2NL-PDE4DIP_NOTCH2NL_chr1_145248894_ENST00000369340_PDE4DIP_chr1_145021167_ENST00000313382_length(amino acids)=2260AA_BP=27
MQCRDGYEPCVNEGMCVTYHNGTGYCKDYFAEDDGEMVPRTSHTAAFLSDTKDRGPPVQSQIWRSGEKVPFVQTYSLRAFEKPPQVQTQA
LRDFEKHLNDLKKENFSLKLRIYFLEERMQQKYEASREDIYKRNIELKVEVESLKRELQDKKQHLDKTWADVENLNSQNEAELRRQFEER
QQETEHVYELLENKIQLLQEESRLAKNEAARMAALVEAEKECNLELSEKLKGVTKNWEDVPGDQVKPDQYTEALAQRDKRIEELNQSLAA
QERLVEQLSREKQQLLHLLEEPTSMEVQPMTEELLKQQKLNSHETTITQQSVSDSHLAELQEKIQQTEATNKILQEKLNEMSYELKCAQE
SSQKQDGTIQNLKETLKSRERETEELYQVIEGQNDTMAKLREMLHQSQLGQLHSSEGTSPAQQQVALLDLQSALFCSQLEIQKLQRVVRQ
KERQLADAKQCVQFVEAAAHESEQQKEASWKHNQELRKALQQLQEELQNKSQQLRAWEAEKYNEIRTQEQNIQHLNHSLSHKEQLLQEFR
ELLQYRDNSDKTLEANEMLLEKLRQRIHDKAVALERAIDEKFSALEEKEKELRQLRLAVRERDHDLERLRDVLSSNEATMQSMESLLRAK
GLEVEQLSTTCQNLQWLKEEMETKFSRWQKEQESIIQQLQTSLHDRNKEVEDLSATLLCKLGPGQSEIAEELCQRLQRKERMLQDLLSDR
NKQVLEHEMEIQGLLQSVSTREQESQAAAEKLVQALMERNSELQALRQYLGGRDSLMSQAPISNQQAEVTPTGCLGKQTDQGSMQIPSRD
DSTSLTAKEDVSIPRSTLGDLDTVAGLEKELSNAKEELELMAKKERESQMELSALQSMMAVQEEELQVQAADMESLTRNIQIKEDLIKDL
QMQLVDPEDIPAMERLTQEVLLLREKVASVESQGQEISGNRRQQLLLMLEGLVDERSRLNEALQAERQLYSSLVKFHAHPESSERDRTLQ
VELEGAQVLRSRLEEVLGRSLERLNRLETLAAIGGAAAGDDTEDTSTEFTDSIEEEAAHHSHQQLVKVALEKSLATVETQNPSFSPPSPM
GGDSNRCLQEEMLHLRAEFHQHLEEKRKAEEELKELKAQIEEAGFSSVSHIRNTMLSLCLENAELKEQMGEAMSDGWEIEEDKEKGELDN
QSQPRDPGPQSAFSLPGSTQHLRSQLSQCKQRYQDLQEKLLLSEATVFAQANELEKYRVMLTGESLVKQDSKQIQVDLQDLGYETCGRSE
NEAEREETTSPECEEHNSLKEMVLMEGLCSEQGRRGSTLASSSERKPLENQLGKQEEFRVYGKSENILVLRKDIKDLKAQLQNANKVIQN
LKSRVRSLSVTSDYSSSLERPWKLRAVGTLEGSSPHSVPDEDEGWLSDGTGAFYSPGLQAKKDLESLIQRVSQLEAQLPKNGLEEKLAEE
LRSASWPGKYDSLIQDQARELSYLRQKIREGRGICYLITRHAKDTVKSFEDLLRSNDIDYYLGQSFREQLAQGSQLTERLTSKLSTKDHK
SEKDQAGLEPLALRLSRELQEKEKVIEVLQAKLDARSLTPSSSHALSDSHRSPSSTSFLSDELEACSDMDIVSEYTHYEEKKASPSHSDS
IHHSSHSAVLSSKPSSTSASQGAKAESNSNPISLPTPQNTPKEANQAHSGASTVPPASTATLLSNDLEADSSYYLNSAQPHSPPRGTIEL
GRILEPGYLGSSGKWDVMRPQKGSVSGDLSSGSSVYQLNSKPTGADLLEEHLGEIRNLRQRLEESICINDRLREQLEHRLTSTARGRGST
SNFYSQGLESIPQLCNENRVLREDNRRLQAQLSHVSREHSQETESLREALLSSRSHLQELEKELEHQKVERQQLLEDLREKQQEVLHFRE
ERLSLQENDSRLQHKLVLLQQQCEEKQQLFESLQSELQIYEALYGNSKKGLKAYSLDACHQIPLSSDLSHLVAEVRALRGQLEQSIQGNN
CLRLQLQQQLESGAGKASLSPSSINQNFPASTDPGNKQLLLQDSAVSPPVRDVGMNSPALVFPSSASSTPGSETPIINRANGLGLDTSPV
MKTPPKLEGDATDGSFANKHGRHVIGHIDDYSALRQQIAEGKLLVKKIVSLVRSACSFPGLEAQGTEVLGSKGIHELRSSTSALHHALEE
SASLLTMFWRAALPSTHIPVLPGKVGESTERELLELRTKVSKQERLLQSTTEHLKNANQQKESMEQFIVSQLTRTHDVLKKARTNLEVKS

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr1:145248894/chr1:145021167)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
NOTCH2NL

P0DPK3

.
FUNCTION: Human-specific protein that promotes neural progenitor proliferation and evolutionary expansion of the brain neocortex by regulating the Notch signaling pathway (PubMed:29856954, PubMed:29856955, PubMed:29561261). Able to promote neural progenitor self-renewal, possibly by down-regulating neuronal differentiation genes, thereby delaying the differentiation of neuronal progenitors and leading to an overall final increase in neuronal production (PubMed:29856954, PubMed:29856955). Acts by enhancing the Notch signaling pathway via two different mechanisms that probably work in parallel to reach the same effect (PubMed:29856954, PubMed:29856955). Enhances Notch signaling pathway in a non-cell-autonomous manner via direct interaction with NOTCH2 (PubMed:29856954). Also promotes Notch signaling pathway in a cell-autonomous manner through inhibition of cis DLL1-NOTCH2 interactions, which promotes neuronal differentiation (PubMed:29856955). {ECO:0000269|PubMed:29561261, ECO:0000269|PubMed:29856954, ECO:0000269|PubMed:29856955}.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgenePDE4DIPchr1:145248894chr1:145021167ENST000003133820461002_10436.6666666666666672241.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:145248894chr1:145021167ENST000003133820461096_11246.6666666666666672241.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:145248894chr1:145021167ENST000003133820461212_12406.6666666666666672241.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:145248894chr1:145021167ENST000003133820461346_13856.6666666666666672241.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:145248894chr1:145021167ENST000003133820461431_14556.6666666666666672241.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:145248894chr1:145021167ENST00000313382046162_2056.6666666666666672241.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:145248894chr1:145021167ENST000003133820461736_17606.6666666666666672241.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:145248894chr1:145021167ENST000003133820461840_20776.6666666666666672241.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:145248894chr1:145021167ENST000003133820462273_23126.6666666666666672241.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:145248894chr1:145021167ENST00000313382046238_3186.6666666666666672241.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:145248894chr1:145021167ENST00000313382046350_6846.6666666666666672241.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:145248894chr1:145021167ENST0000031338204641_1326.6666666666666672241.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:145248894chr1:145021167ENST00000313382046743_9366.6666666666666672241.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:145248894chr1:145021167ENST000003134310191002_104301133.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:145248894chr1:145021167ENST000003134310191096_112401133.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:145248894chr1:145021167ENST000003134310191212_124001133.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:145248894chr1:145021167ENST000003134310191346_138501133.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:145248894chr1:145021167ENST000003134310191431_145501133.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:145248894chr1:145021167ENST00000313431019162_20501133.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:145248894chr1:145021167ENST000003134310191736_176001133.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:145248894chr1:145021167ENST000003134310191840_207701133.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:145248894chr1:145021167ENST000003134310192273_231201133.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:145248894chr1:145021167ENST00000313431019238_31801133.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:145248894chr1:145021167ENST00000313431019350_68401133.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:145248894chr1:145021167ENST0000031343101941_13201133.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:145248894chr1:145021167ENST00000313431019743_93601133.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:145248894chr1:145021167ENST00000369347041002_10430174.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:145248894chr1:145021167ENST00000369347041096_11240174.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:145248894chr1:145021167ENST00000369347041212_12400174.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:145248894chr1:145021167ENST00000369347041346_13850174.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:145248894chr1:145021167ENST00000369347041431_14550174.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:145248894chr1:145021167ENST0000036934704162_2050174.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:145248894chr1:145021167ENST00000369347041736_17600174.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:145248894chr1:145021167ENST00000369347041840_20770174.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:145248894chr1:145021167ENST00000369347042273_23120174.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:145248894chr1:145021167ENST0000036934704238_3180174.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:145248894chr1:145021167ENST0000036934704350_6840174.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:145248894chr1:145021167ENST000003693470441_1320174.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:145248894chr1:145021167ENST0000036934704743_9360174.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:145248894chr1:145021167ENST00000369348071002_104377.66666666666667311.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:145248894chr1:145021167ENST00000369348071096_112477.66666666666667311.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:145248894chr1:145021167ENST00000369348071212_124077.66666666666667311.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:145248894chr1:145021167ENST00000369348071346_138577.66666666666667311.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:145248894chr1:145021167ENST00000369348071431_145577.66666666666667311.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:145248894chr1:145021167ENST0000036934807162_20577.66666666666667311.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:145248894chr1:145021167ENST00000369348071736_176077.66666666666667311.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:145248894chr1:145021167ENST00000369348071840_207777.66666666666667311.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:145248894chr1:145021167ENST00000369348072273_231277.66666666666667311.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:145248894chr1:145021167ENST0000036934807238_31877.66666666666667311.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:145248894chr1:145021167ENST0000036934807350_68477.66666666666667311.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:145248894chr1:145021167ENST0000036934807743_93677.66666666666667311.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:145248894chr1:145021167ENST000003693490231002_10430970.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:145248894chr1:145021167ENST000003693490231096_11240970.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:145248894chr1:145021167ENST000003693490231212_12400970.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:145248894chr1:145021167ENST000003693490231346_13850970.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:145248894chr1:145021167ENST000003693490231431_14550970.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:145248894chr1:145021167ENST00000369349023162_2050970.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:145248894chr1:145021167ENST000003693490231736_17600970.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:145248894chr1:145021167ENST000003693490231840_20770970.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:145248894chr1:145021167ENST000003693490232273_23120970.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:145248894chr1:145021167ENST00000369349023238_3180970.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:145248894chr1:145021167ENST00000369349023350_6840970.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:145248894chr1:145021167ENST0000036934902341_1320970.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:145248894chr1:145021167ENST00000369349023743_9360970.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:145248894chr1:145021167ENST000003693510221002_10430989.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:145248894chr1:145021167ENST000003693510221096_11240989.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:145248894chr1:145021167ENST000003693510221212_12400989.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:145248894chr1:145021167ENST000003693510221346_13850989.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:145248894chr1:145021167ENST000003693510221431_14550989.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:145248894chr1:145021167ENST00000369351022162_2050989.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:145248894chr1:145021167ENST000003693510221736_17600989.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:145248894chr1:145021167ENST000003693510221840_20770989.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:145248894chr1:145021167ENST000003693510222273_23120989.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:145248894chr1:145021167ENST00000369351022238_3180989.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:145248894chr1:145021167ENST00000369351022350_6840989.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:145248894chr1:145021167ENST0000036935102241_1320989.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:145248894chr1:145021167ENST00000369351022743_9360989.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:145248894chr1:145021167ENST000003693540441002_104302347.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:145248894chr1:145021167ENST000003693540441096_112402347.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:145248894chr1:145021167ENST000003693540441212_124002347.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:145248894chr1:145021167ENST000003693540441346_138502347.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:145248894chr1:145021167ENST000003693540441431_145502347.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:145248894chr1:145021167ENST00000369354044162_20502347.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:145248894chr1:145021167ENST000003693540441736_176002347.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:145248894chr1:145021167ENST000003693540441840_207702347.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:145248894chr1:145021167ENST000003693540442273_231202347.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:145248894chr1:145021167ENST00000369354044238_31802347.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:145248894chr1:145021167ENST00000369354044350_68402347.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:145248894chr1:145021167ENST0000036935404441_13202347.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:145248894chr1:145021167ENST00000369354044743_93602347.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:145248894chr1:145021167ENST000003693560441002_104302363.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:145248894chr1:145021167ENST000003693560441096_112402363.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:145248894chr1:145021167ENST000003693560441212_124002363.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:145248894chr1:145021167ENST000003693560441346_138502363.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:145248894chr1:145021167ENST000003693560441431_145502363.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:145248894chr1:145021167ENST00000369356044162_20502363.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:145248894chr1:145021167ENST000003693560441736_176002363.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:145248894chr1:145021167ENST000003693560441840_207702363.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:145248894chr1:145021167ENST000003693560442273_231202363.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:145248894chr1:145021167ENST00000369356044238_31802363.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:145248894chr1:145021167ENST00000369356044350_68402363.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:145248894chr1:145021167ENST0000036935604441_13202363.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:145248894chr1:145021167ENST00000369356044743_93602363.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:145248894chr1:145021167ENST000003133820461551_16426.6666666666666672241.0DomainOlduvai
TgenePDE4DIPchr1:145248894chr1:145021167ENST000003134310191551_164201133.0DomainOlduvai
TgenePDE4DIPchr1:145248894chr1:145021167ENST00000369347041551_16420174.0DomainOlduvai
TgenePDE4DIPchr1:145248894chr1:145021167ENST00000369348071551_164277.66666666666667311.0DomainOlduvai
TgenePDE4DIPchr1:145248894chr1:145021167ENST000003693490231551_16420970.0DomainOlduvai
TgenePDE4DIPchr1:145248894chr1:145021167ENST000003693510221551_16420989.0DomainOlduvai
TgenePDE4DIPchr1:145248894chr1:145021167ENST000003693540441551_164202347.0DomainOlduvai
TgenePDE4DIPchr1:145248894chr1:145021167ENST000003693560441551_164202363.0DomainOlduvai

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneNOTCH2NLchr1:145248894chr1:145021167ENST00000344859+26105_14112.666666666666666416.3333333333333DomainEGF-like 4
HgeneNOTCH2NLchr1:145248894chr1:145021167ENST00000344859+26143_18012.666666666666666416.3333333333333DomainEGF-like 5%3B calcium-binding
HgeneNOTCH2NLchr1:145248894chr1:145021167ENST00000344859+26182_21912.666666666666666416.3333333333333DomainEGF-like 6
HgeneNOTCH2NLchr1:145248894chr1:145021167ENST00000344859+261_2412.666666666666666416.3333333333333DomainEGF-like 1
HgeneNOTCH2NLchr1:145248894chr1:145021167ENST00000344859+2625_6312.666666666666666416.3333333333333DomainEGF-like 2
HgeneNOTCH2NLchr1:145248894chr1:145021167ENST00000344859+2666_10412.666666666666666416.3333333333333DomainEGF-like 3
HgeneNOTCH2NLchr1:145248894chr1:145021167ENST00000362074+25105_14112.666666666666666237.0DomainEGF-like 4
HgeneNOTCH2NLchr1:145248894chr1:145021167ENST00000362074+25143_18012.666666666666666237.0DomainEGF-like 5%3B calcium-binding
HgeneNOTCH2NLchr1:145248894chr1:145021167ENST00000362074+25182_21912.666666666666666237.0DomainEGF-like 6
HgeneNOTCH2NLchr1:145248894chr1:145021167ENST00000362074+251_2412.666666666666666237.0DomainEGF-like 1
HgeneNOTCH2NLchr1:145248894chr1:145021167ENST00000362074+2525_6312.666666666666666237.0DomainEGF-like 2
HgeneNOTCH2NLchr1:145248894chr1:145021167ENST00000362074+2566_10412.666666666666666237.0DomainEGF-like 3
HgeneNOTCH2NLchr1:145248894chr1:145021167ENST00000369340+36105_14112.666666666666666237.0DomainEGF-like 4
HgeneNOTCH2NLchr1:145248894chr1:145021167ENST00000369340+36143_18012.666666666666666237.0DomainEGF-like 5%3B calcium-binding
HgeneNOTCH2NLchr1:145248894chr1:145021167ENST00000369340+36182_21912.666666666666666237.0DomainEGF-like 6
HgeneNOTCH2NLchr1:145248894chr1:145021167ENST00000369340+361_2412.666666666666666237.0DomainEGF-like 1
HgeneNOTCH2NLchr1:145248894chr1:145021167ENST00000369340+3625_6312.666666666666666237.0DomainEGF-like 2
HgeneNOTCH2NLchr1:145248894chr1:145021167ENST00000369340+3666_10412.666666666666666237.0DomainEGF-like 3
TgenePDE4DIPchr1:145248894chr1:145021167ENST000003693480741_13277.66666666666667311.0Coiled coilOntology_term=ECO:0000255


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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
NOTCH2NL
PDE4DIP


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to NOTCH2NL-PDE4DIP


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to NOTCH2NL-PDE4DIP


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource