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Center for Computational Systems Medicine level1
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:NRG1-LRRC28

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: NRG1-LRRC28
FusionPDB ID: 60275
FusionGDB2.0 ID: 60275
HgeneTgene
Gene symbol

NRG1

LRRC28

Gene ID

3084

123355

Gene nameneuregulin 1leucine rich repeat containing 28
SynonymsARIA|GGF|GGF2|HGL|HRG|HRG1|HRGA|MST131|MSTP131|NDF|NRG1-IT2|SMDF-
Cytomap

8p12

15q26.3

Type of geneprotein-codingprotein-coding
Descriptionpro-neuregulin-1, membrane-bound isoformacetylcholine receptor-inducing activityglial growth factor 2heregulin, alpha (45kD, ERBB2 p185-activator)neu differentiation factorpro-NRG1sensory and motor neuron derived factorleucine-rich repeat-containing protein 28
Modification date2020032020200313
UniProtAcc

Q02297

Q86X40

Ensembl transtripts involved in fusion geneENST idsENST00000287842, ENST00000338921, 
ENST00000341377, ENST00000356819, 
ENST00000405005, ENST00000521670, 
ENST00000523079, ENST00000287845, 
ENST00000519301, ENST00000520407, 
ENST00000520502, ENST00000523681, 
ENST00000539990, 		ENST00000331450, 
ENST00000442993, ENST00000447360, 
ENST00000559399, ENST00000301981, 
ENST00000422500, ENST00000558879, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score12 X 10 X 7=84015 X 11 X 9=1485
# samples 1219
** MAII scorelog2(12/840*10)=-2.8073549220576
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(19/1485*10)=-2.96639160735718
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: NRG1 [Title/Abstract] AND LRRC28 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)NRG1(32474403)-LRRC28(99926234), # samples:1
Anticipated loss of major functional domain due to fusion event.NRG1-LRRC28 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
NRG1-LRRC28 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
NRG1-LRRC28 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
NRG1-LRRC28 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
NRG1-LRRC28 seems lost the major protein functional domain in Hgene partner, which is a CGC due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneNRG1

GO:0003222

ventricular trabecula myocardium morphogenesis

17336907

HgeneNRG1

GO:0031334

positive regulation of protein complex assembly

10559227

HgeneNRG1

GO:0038127

ERBB signaling pathway

11389077

HgeneNRG1

GO:0038129

ERBB3 signaling pathway

27353365

HgeneNRG1

GO:0045892

negative regulation of transcription, DNA-templated

15073182

HgeneNRG1

GO:0051048

negative regulation of secretion

10559227

HgeneNRG1

GO:0060379

cardiac muscle cell myoblast differentiation

17336907

HgeneNRG1

GO:0060956

endocardial cell differentiation

17336907


check buttonFusion gene breakpoints across NRG1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across LRRC28 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4ESCATCGA-JY-A6FENRG1chr8

32474403

+LRRC28chr15

99926234

+


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000523079NRG1chr832474403+ENST00000558879LRRC28chr1599926234+119210191541020288
ENST00000523079NRG1chr832474403+ENST00000422500LRRC28chr1599926234+142410191541020288
ENST00000338921NRG1chr832474403+ENST00000558879LRRC28chr1599926234+119210191541020288
ENST00000338921NRG1chr832474403+ENST00000422500LRRC28chr1599926234+142410191541020288
ENST00000356819NRG1chr832474403+ENST00000558879LRRC28chr1599926234+119210191541020288
ENST00000356819NRG1chr832474403+ENST00000422500LRRC28chr1599926234+142410191541020288
ENST00000341377NRG1chr832474403+ENST00000558879LRRC28chr1599926234+119210191541020288
ENST00000341377NRG1chr832474403+ENST00000422500LRRC28chr1599926234+142410191541020288
ENST00000287842NRG1chr832474403+ENST00000558879LRRC28chr1599926234+113596297963288
ENST00000287842NRG1chr832474403+ENST00000422500LRRC28chr1599926234+136796297963288
ENST00000521670NRG1chr832474403+ENST00000558879LRRC28chr1599926234+7836106612220
ENST00000521670NRG1chr832474403+ENST00000422500LRRC28chr1599926234+1015610108611167
ENST00000405005NRG1chr832474403+ENST00000558879LRRC28chr1599926234+6755025532184
ENST00000405005NRG1chr832474403+ENST00000422500LRRC28chr1599926234+9075020503167

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000523079ENST00000558879NRG1chr832474403+LRRC28chr1599926234+0.0174875560.9825125
ENST00000523079ENST00000422500NRG1chr832474403+LRRC28chr1599926234+0.0230941160.9769059
ENST00000338921ENST00000558879NRG1chr832474403+LRRC28chr1599926234+0.0174875560.9825125
ENST00000338921ENST00000422500NRG1chr832474403+LRRC28chr1599926234+0.0230941160.9769059
ENST00000356819ENST00000558879NRG1chr832474403+LRRC28chr1599926234+0.0174875560.9825125
ENST00000356819ENST00000422500NRG1chr832474403+LRRC28chr1599926234+0.0230941160.9769059
ENST00000341377ENST00000558879NRG1chr832474403+LRRC28chr1599926234+0.0174875560.9825125
ENST00000341377ENST00000422500NRG1chr832474403+LRRC28chr1599926234+0.0230941160.9769059
ENST00000287842ENST00000558879NRG1chr832474403+LRRC28chr1599926234+0.0144494030.98555064
ENST00000287842ENST00000422500NRG1chr832474403+LRRC28chr1599926234+0.0152277050.98477226
ENST00000521670ENST00000558879NRG1chr832474403+LRRC28chr1599926234+0.0121106040.98788935
ENST00000521670ENST00000422500NRG1chr832474403+LRRC28chr1599926234+0.0128970130.9871029
ENST00000405005ENST00000558879NRG1chr832474403+LRRC28chr1599926234+0.0049143940.99508554
ENST00000405005ENST00000422500NRG1chr832474403+LRRC28chr1599926234+0.0040505310.9959494

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>60275_60275_1_NRG1-LRRC28_NRG1_chr8_32474403_ENST00000287842_LRRC28_chr15_99926234_ENST00000422500_length(amino acids)=288AA_BP=
MPDDGSVSRTVITSPRSGCEGAGQRPGREPPAVGPIDDFPGRQEQPREPGRAPVPGGRTARRVRAALPAGNGRRPRAARAPQRGRSLSPS
RDKLFPNPIRALGPNSPAPRAVRVERSVSGEMSERKEGRGKGKGKKKERGSGKKPESAAGSQSPALPPRLKEMKSQESAAGSKLVLRCET
SSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKSELRINKASLADSGEYMCKVISKLGNDSASANITIVESNEIITGMPASTEGAYVS

--------------------------------------------------------------

>60275_60275_2_NRG1-LRRC28_NRG1_chr8_32474403_ENST00000287842_LRRC28_chr15_99926234_ENST00000558879_length(amino acids)=288AA_BP=
MPDDGSVSRTVITSPRSGCEGAGQRPGREPPAVGPIDDFPGRQEQPREPGRAPVPGGRTARRVRAALPAGNGRRPRAARAPQRGRSLSPS
RDKLFPNPIRALGPNSPAPRAVRVERSVSGEMSERKEGRGKGKGKKKERGSGKKPESAAGSQSPALPPRLKEMKSQESAAGSKLVLRCET
SSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKSELRINKASLADSGEYMCKVISKLGNDSASANITIVESNEIITGMPASTEGAYVS

--------------------------------------------------------------

>60275_60275_3_NRG1-LRRC28_NRG1_chr8_32474403_ENST00000338921_LRRC28_chr15_99926234_ENST00000422500_length(amino acids)=288AA_BP=
MPDDGSVSRTVITSPRSGCEGAGQRPGREPPAVGPIDDFPGRQEQPREPGRAPVPGGRTARRVRAALPAGNGRRPRAARAPQRGRSLSPS
RDKLFPNPIRALGPNSPAPRAVRVERSVSGEMSERKEGRGKGKGKKKERGSGKKPESAAGSQSPALPPRLKEMKSQESAAGSKLVLRCET
SSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKSELRINKASLADSGEYMCKVISKLGNDSASANITIVESNEIITGMPASTEGAYVS

--------------------------------------------------------------

>60275_60275_4_NRG1-LRRC28_NRG1_chr8_32474403_ENST00000338921_LRRC28_chr15_99926234_ENST00000558879_length(amino acids)=288AA_BP=
MPDDGSVSRTVITSPRSGCEGAGQRPGREPPAVGPIDDFPGRQEQPREPGRAPVPGGRTARRVRAALPAGNGRRPRAARAPQRGRSLSPS
RDKLFPNPIRALGPNSPAPRAVRVERSVSGEMSERKEGRGKGKGKKKERGSGKKPESAAGSQSPALPPRLKEMKSQESAAGSKLVLRCET
SSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKSELRINKASLADSGEYMCKVISKLGNDSASANITIVESNEIITGMPASTEGAYVS

--------------------------------------------------------------

>60275_60275_5_NRG1-LRRC28_NRG1_chr8_32474403_ENST00000341377_LRRC28_chr15_99926234_ENST00000422500_length(amino acids)=288AA_BP=
MPDDGSVSRTVITSPRSGCEGAGQRPGREPPAVGPIDDFPGRQEQPREPGRAPVPGGRTARRVRAALPAGNGRRPRAARAPQRGRSLSPS
RDKLFPNPIRALGPNSPAPRAVRVERSVSGEMSERKEGRGKGKGKKKERGSGKKPESAAGSQSPALPPRLKEMKSQESAAGSKLVLRCET
SSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKSELRINKASLADSGEYMCKVISKLGNDSASANITIVESNEIITGMPASTEGAYVS

--------------------------------------------------------------

>60275_60275_6_NRG1-LRRC28_NRG1_chr8_32474403_ENST00000341377_LRRC28_chr15_99926234_ENST00000558879_length(amino acids)=288AA_BP=
MPDDGSVSRTVITSPRSGCEGAGQRPGREPPAVGPIDDFPGRQEQPREPGRAPVPGGRTARRVRAALPAGNGRRPRAARAPQRGRSLSPS
RDKLFPNPIRALGPNSPAPRAVRVERSVSGEMSERKEGRGKGKGKKKERGSGKKPESAAGSQSPALPPRLKEMKSQESAAGSKLVLRCET
SSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKSELRINKASLADSGEYMCKVISKLGNDSASANITIVESNEIITGMPASTEGAYVS

--------------------------------------------------------------

>60275_60275_7_NRG1-LRRC28_NRG1_chr8_32474403_ENST00000356819_LRRC28_chr15_99926234_ENST00000422500_length(amino acids)=288AA_BP=
MPDDGSVSRTVITSPRSGCEGAGQRPGREPPAVGPIDDFPGRQEQPREPGRAPVPGGRTARRVRAALPAGNGRRPRAARAPQRGRSLSPS
RDKLFPNPIRALGPNSPAPRAVRVERSVSGEMSERKEGRGKGKGKKKERGSGKKPESAAGSQSPALPPRLKEMKSQESAAGSKLVLRCET
SSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKSELRINKASLADSGEYMCKVISKLGNDSASANITIVESNEIITGMPASTEGAYVS

--------------------------------------------------------------

>60275_60275_8_NRG1-LRRC28_NRG1_chr8_32474403_ENST00000356819_LRRC28_chr15_99926234_ENST00000558879_length(amino acids)=288AA_BP=
MPDDGSVSRTVITSPRSGCEGAGQRPGREPPAVGPIDDFPGRQEQPREPGRAPVPGGRTARRVRAALPAGNGRRPRAARAPQRGRSLSPS
RDKLFPNPIRALGPNSPAPRAVRVERSVSGEMSERKEGRGKGKGKKKERGSGKKPESAAGSQSPALPPRLKEMKSQESAAGSKLVLRCET
SSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKSELRINKASLADSGEYMCKVISKLGNDSASANITIVESNEIITGMPASTEGAYVS

--------------------------------------------------------------

>60275_60275_9_NRG1-LRRC28_NRG1_chr8_32474403_ENST00000405005_LRRC28_chr15_99926234_ENST00000422500_length(amino acids)=167AA_BP=
MSERKEGRGKGKGKKKERGSGKKPESAAGSQSPALPPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQK

--------------------------------------------------------------

>60275_60275_10_NRG1-LRRC28_NRG1_chr8_32474403_ENST00000405005_LRRC28_chr15_99926234_ENST00000558879_length(amino acids)=184AA_BP=1
MQTLGGAAVSHKTNSCLHEEVFAPSVDTDILMGDSEDTYAPSVEAGIPVMISFDSTMVILAEALSFPNLLITLHIYSPESASDALLMRSS
DFPGFFCILIFCGLFFRFNSFPFLNHLNLREEYSELVSHRRTSLEPAADSWLFISFNRGGKAGLWLPAADSGFLPEPRSFFLPFPLPLPS

--------------------------------------------------------------

>60275_60275_11_NRG1-LRRC28_NRG1_chr8_32474403_ENST00000521670_LRRC28_chr15_99926234_ENST00000422500_length(amino acids)=167AA_BP=
MSERKEGRGKGKGKKKERGSGKKPESAAGSQSPALPPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQK

--------------------------------------------------------------

>60275_60275_12_NRG1-LRRC28_NRG1_chr8_32474403_ENST00000521670_LRRC28_chr15_99926234_ENST00000558879_length(amino acids)=220AA_BP=1
MQTLGGAAVSHKTNSCLHEEVFAPSVDTDILMGDSEDTYAPSVEAGIPVMISFDSTMVILAEALSFPNLLITLHIYSPESASDALLMRSS
DFPGFFCILIFCGLFFRFNSFPFLNHLNLREEYSELVSHRRTSLEPAADSWLFISFNRGGKAGLWLPAADSGFLPEPRSFFLPFPLPLPS

--------------------------------------------------------------

>60275_60275_13_NRG1-LRRC28_NRG1_chr8_32474403_ENST00000523079_LRRC28_chr15_99926234_ENST00000422500_length(amino acids)=288AA_BP=
MPDDGSVSRTVITSPRSGCEGAGQRPGREPPAVGPIDDFPGRQEQPREPGRAPVPGGRTARRVRAALPAGNGRRPRAARAPQRGRSLSPS
RDKLFPNPIRALGPNSPAPRAVRVERSVSGEMSERKEGRGKGKGKKKERGSGKKPESAAGSQSPALPPRLKEMKSQESAAGSKLVLRCET
SSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKSELRINKASLADSGEYMCKVISKLGNDSASANITIVESNEIITGMPASTEGAYVS

--------------------------------------------------------------

>60275_60275_14_NRG1-LRRC28_NRG1_chr8_32474403_ENST00000523079_LRRC28_chr15_99926234_ENST00000558879_length(amino acids)=288AA_BP=
MPDDGSVSRTVITSPRSGCEGAGQRPGREPPAVGPIDDFPGRQEQPREPGRAPVPGGRTARRVRAALPAGNGRRPRAARAPQRGRSLSPS
RDKLFPNPIRALGPNSPAPRAVRVERSVSGEMSERKEGRGKGKGKKKERGSGKKPESAAGSQSPALPPRLKEMKSQESAAGSKLVLRCET
SSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKSELRINKASLADSGEYMCKVISKLGNDSASANITIVESNEIITGMPASTEGAYVS

--------------------------------------------------------------

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr8:32474403/chr15:99926234)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
NRG1

Q02297

LRRC28

Q86X40

FUNCTION: Direct ligand for ERBB3 and ERBB4 tyrosine kinase receptors. Concomitantly recruits ERBB1 and ERBB2 coreceptors, resulting in ligand-stimulated tyrosine phosphorylation and activation of the ERBB receptors. The multiple isoforms perform diverse functions such as inducing growth and differentiation of epithelial, glial, neuronal, and skeletal muscle cells; inducing expression of acetylcholine receptor in synaptic vesicles during the formation of the neuromuscular junction; stimulating lobuloalveolar budding and milk production in the mammary gland and inducing differentiation of mammary tumor cells; stimulating Schwann cell proliferation; implication in the development of the myocardium such as trabeculation of the developing heart. Isoform 10 may play a role in motor and sensory neuron development. Binds to ERBB4 (PubMed:10867024, PubMed:7902537). Binds to ERBB3 (PubMed:20682778). Acts as a ligand for integrins and binds (via EGF domain) to integrins ITGAV:ITGB3 or ITGA6:ITGB4. Its binding to integrins and subsequent ternary complex formation with integrins and ERRB3 are essential for NRG1-ERBB signaling. Induces the phosphorylation and activation of MAPK3/ERK1, MAPK1/ERK2 and AKT1 (PubMed:20682778). Ligand-dependent ERBB4 endocytosis is essential for the NRG1-mediated activation of these kinases in neurons (By similarity). {ECO:0000250|UniProtKB:P43322, ECO:0000269|PubMed:10867024, ECO:0000269|PubMed:1348215, ECO:0000269|PubMed:20682778, ECO:0000269|PubMed:7902537}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneNRG1chr8:32474403chr15:99926234ENST00000287842+51237_128167.33333333333334638.0DomainNote=Ig-like C2-type
HgeneNRG1chr8:32474403chr15:99926234ENST00000341377+51337_128167.33333333333334525.3333333333334DomainNote=Ig-like C2-type
HgeneNRG1chr8:32474403chr15:99926234ENST00000356819+51337_128167.33333333333334646.0DomainNote=Ig-like C2-type
HgeneNRG1chr8:32474403chr15:99926234ENST00000405005+51237_128167.33333333333334641.0DomainNote=Ig-like C2-type
HgeneNRG1chr8:32474403chr15:99926234ENST00000521670+51337_128167.33333333333334477.3333333333333DomainNote=Ig-like C2-type
HgeneNRG1chr8:32474403chr15:99926234ENST00000523079+51137_128167.33333333333334421.0DomainNote=Ig-like C2-type

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneNRG1chr8:32474403chr15:99926234ENST00000287842+512165_177167.33333333333334638.0Compositional biasNote=Ser/Thr-rich
HgeneNRG1chr8:32474403chr15:99926234ENST00000341377+513165_177167.33333333333334525.3333333333334Compositional biasNote=Ser/Thr-rich
HgeneNRG1chr8:32474403chr15:99926234ENST00000356819+513165_177167.33333333333334646.0Compositional biasNote=Ser/Thr-rich
HgeneNRG1chr8:32474403chr15:99926234ENST00000405005+512165_177167.33333333333334641.0Compositional biasNote=Ser/Thr-rich
HgeneNRG1chr8:32474403chr15:99926234ENST00000519301+111165_1770591.0Compositional biasNote=Ser/Thr-rich
HgeneNRG1chr8:32474403chr15:99926234ENST00000520407+15165_1770423.0Compositional biasNote=Ser/Thr-rich
HgeneNRG1chr8:32474403chr15:99926234ENST00000520502+13165_1770.0297.0Compositional biasNote=Ser/Thr-rich
HgeneNRG1chr8:32474403chr15:99926234ENST00000521670+513165_177167.33333333333334477.3333333333333Compositional biasNote=Ser/Thr-rich
HgeneNRG1chr8:32474403chr15:99926234ENST00000523079+511165_177167.33333333333334421.0Compositional biasNote=Ser/Thr-rich
HgeneNRG1chr8:32474403chr15:99926234ENST00000287842+512178_222167.33333333333334638.0DomainEGF-like
HgeneNRG1chr8:32474403chr15:99926234ENST00000341377+513178_222167.33333333333334525.3333333333334DomainEGF-like
HgeneNRG1chr8:32474403chr15:99926234ENST00000356819+513178_222167.33333333333334646.0DomainEGF-like
HgeneNRG1chr8:32474403chr15:99926234ENST00000405005+512178_222167.33333333333334641.0DomainEGF-like
HgeneNRG1chr8:32474403chr15:99926234ENST00000519301+111178_2220591.0DomainEGF-like
HgeneNRG1chr8:32474403chr15:99926234ENST00000519301+11137_1280591.0DomainNote=Ig-like C2-type
HgeneNRG1chr8:32474403chr15:99926234ENST00000520407+15178_2220423.0DomainEGF-like
HgeneNRG1chr8:32474403chr15:99926234ENST00000520407+1537_1280423.0DomainNote=Ig-like C2-type
HgeneNRG1chr8:32474403chr15:99926234ENST00000520502+13178_2220.0297.0DomainEGF-like
HgeneNRG1chr8:32474403chr15:99926234ENST00000520502+1337_1280.0297.0DomainNote=Ig-like C2-type
HgeneNRG1chr8:32474403chr15:99926234ENST00000521670+513178_222167.33333333333334477.3333333333333DomainEGF-like
HgeneNRG1chr8:32474403chr15:99926234ENST00000523079+511178_222167.33333333333334421.0DomainEGF-like
HgeneNRG1chr8:32474403chr15:99926234ENST00000287842+51220_242167.33333333333334638.0Topological domainExtracellular
HgeneNRG1chr8:32474403chr15:99926234ENST00000287842+512266_640167.33333333333334638.0Topological domainCytoplasmic
HgeneNRG1chr8:32474403chr15:99926234ENST00000341377+51320_242167.33333333333334525.3333333333334Topological domainExtracellular
HgeneNRG1chr8:32474403chr15:99926234ENST00000341377+513266_640167.33333333333334525.3333333333334Topological domainCytoplasmic
HgeneNRG1chr8:32474403chr15:99926234ENST00000356819+51320_242167.33333333333334646.0Topological domainExtracellular
HgeneNRG1chr8:32474403chr15:99926234ENST00000356819+513266_640167.33333333333334646.0Topological domainCytoplasmic
HgeneNRG1chr8:32474403chr15:99926234ENST00000405005+51220_242167.33333333333334641.0Topological domainExtracellular
HgeneNRG1chr8:32474403chr15:99926234ENST00000405005+512266_640167.33333333333334641.0Topological domainCytoplasmic
HgeneNRG1chr8:32474403chr15:99926234ENST00000519301+11120_2420591.0Topological domainExtracellular
HgeneNRG1chr8:32474403chr15:99926234ENST00000519301+111266_6400591.0Topological domainCytoplasmic
HgeneNRG1chr8:32474403chr15:99926234ENST00000520407+1520_2420423.0Topological domainExtracellular
HgeneNRG1chr8:32474403chr15:99926234ENST00000520407+15266_6400423.0Topological domainCytoplasmic
HgeneNRG1chr8:32474403chr15:99926234ENST00000520502+1320_2420.0297.0Topological domainExtracellular
HgeneNRG1chr8:32474403chr15:99926234ENST00000520502+13266_6400.0297.0Topological domainCytoplasmic
HgeneNRG1chr8:32474403chr15:99926234ENST00000521670+51320_242167.33333333333334477.3333333333333Topological domainExtracellular
HgeneNRG1chr8:32474403chr15:99926234ENST00000521670+513266_640167.33333333333334477.3333333333333Topological domainCytoplasmic
HgeneNRG1chr8:32474403chr15:99926234ENST00000523079+51120_242167.33333333333334421.0Topological domainExtracellular
HgeneNRG1chr8:32474403chr15:99926234ENST00000523079+511266_640167.33333333333334421.0Topological domainCytoplasmic
HgeneNRG1chr8:32474403chr15:99926234ENST00000287842+512243_265167.33333333333334638.0TransmembraneHelical%3B Note%3DInternal signal sequence
HgeneNRG1chr8:32474403chr15:99926234ENST00000341377+513243_265167.33333333333334525.3333333333334TransmembraneHelical%3B Note%3DInternal signal sequence
HgeneNRG1chr8:32474403chr15:99926234ENST00000356819+513243_265167.33333333333334646.0TransmembraneHelical%3B Note%3DInternal signal sequence
HgeneNRG1chr8:32474403chr15:99926234ENST00000405005+512243_265167.33333333333334641.0TransmembraneHelical%3B Note%3DInternal signal sequence
HgeneNRG1chr8:32474403chr15:99926234ENST00000519301+111243_2650591.0TransmembraneHelical%3B Note%3DInternal signal sequence
HgeneNRG1chr8:32474403chr15:99926234ENST00000520407+15243_2650423.0TransmembraneHelical%3B Note%3DInternal signal sequence
HgeneNRG1chr8:32474403chr15:99926234ENST00000520502+13243_2650.0297.0TransmembraneHelical%3B Note%3DInternal signal sequence
HgeneNRG1chr8:32474403chr15:99926234ENST00000521670+513243_265167.33333333333334477.3333333333333TransmembraneHelical%3B Note%3DInternal signal sequence
HgeneNRG1chr8:32474403chr15:99926234ENST00000523079+511243_265167.33333333333334421.0TransmembraneHelical%3B Note%3DInternal signal sequence
TgeneLRRC28chr8:32474403chr15:99926234ENST00000301981810112_133343.6666666666667368.0RepeatNote=LRR 5
TgeneLRRC28chr8:32474403chr15:99926234ENST00000301981810135_156343.6666666666667368.0RepeatNote=LRR 6
TgeneLRRC28chr8:32474403chr15:99926234ENST00000301981810158_180343.6666666666667368.0RepeatNote=LRR 7
TgeneLRRC28chr8:32474403chr15:99926234ENST0000030198181016_36343.6666666666667368.0RepeatNote=LRR 1
TgeneLRRC28chr8:32474403chr15:99926234ENST00000301981810181_202343.6666666666667368.0RepeatNote=LRR 8
TgeneLRRC28chr8:32474403chr15:99926234ENST00000301981810204_226343.6666666666667368.0RepeatNote=LRR 9
TgeneLRRC28chr8:32474403chr15:99926234ENST0000030198181042_63343.6666666666667368.0RepeatNote=LRR 2
TgeneLRRC28chr8:32474403chr15:99926234ENST0000030198181066_87343.6666666666667368.0RepeatNote=LRR 3
TgeneLRRC28chr8:32474403chr15:99926234ENST0000030198181089_110343.6666666666667368.0RepeatNote=LRR 4
TgeneLRRC28chr8:32474403chr15:99926234ENST0000044736079112_133290.3333333333333313.0RepeatNote=LRR 5
TgeneLRRC28chr8:32474403chr15:99926234ENST0000044736079135_156290.3333333333333313.0RepeatNote=LRR 6
TgeneLRRC28chr8:32474403chr15:99926234ENST0000044736079158_180290.3333333333333313.0RepeatNote=LRR 7
TgeneLRRC28chr8:32474403chr15:99926234ENST000004473607916_36290.3333333333333313.0RepeatNote=LRR 1
TgeneLRRC28chr8:32474403chr15:99926234ENST0000044736079181_202290.3333333333333313.0RepeatNote=LRR 8
TgeneLRRC28chr8:32474403chr15:99926234ENST0000044736079204_226290.3333333333333313.0RepeatNote=LRR 9
TgeneLRRC28chr8:32474403chr15:99926234ENST000004473607942_63290.3333333333333313.0RepeatNote=LRR 2
TgeneLRRC28chr8:32474403chr15:99926234ENST000004473607966_87290.3333333333333313.0RepeatNote=LRR 3
TgeneLRRC28chr8:32474403chr15:99926234ENST000004473607989_110290.3333333333333313.0RepeatNote=LRR 4


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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
NRG1all structure
LRRC28


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to NRG1-LRRC28


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to NRG1-LRRC28


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneNRG1C0036341Schizophrenia7CTD_human
HgeneNRG1C0005586Bipolar Disorder5PSYGENET
HgeneNRG1C0024809Marijuana Abuse3PSYGENET
HgeneNRG1C0011570Mental Depression2PSYGENET
HgeneNRG1C0011581Depressive disorder2PSYGENET
HgeneNRG1C0006142Malignant neoplasm of breast1CTD_human
HgeneNRG1C0006870Cannabis Dependence1PSYGENET
HgeneNRG1C0007621Neoplastic Cell Transformation1CTD_human
HgeneNRG1C0011616Contact Dermatitis1CTD_human
HgeneNRG1C0018801Heart failure1CTD_human
HgeneNRG1C0018802Congestive heart failure1CTD_human
HgeneNRG1C0019569Hirschsprung Disease1CTD_human
HgeneNRG1C0023212Left-Sided Heart Failure1CTD_human
HgeneNRG1C0023893Liver Cirrhosis, Experimental1CTD_human
HgeneNRG1C0024121Lung Neoplasms1CTD_human
HgeneNRG1C0026650Movement Disorders1CTD_human
HgeneNRG1C0027626Neoplasm Invasiveness1CTD_human
HgeneNRG1C0030193Pain1CTD_human
HgeneNRG1C0032460Polycystic Ovary Syndrome1CTD_human
HgeneNRG1C0038358Gastric ulcer1CTD_human
HgeneNRG1C0085758Aganglionosis, Colonic1CTD_human
HgeneNRG1C0087031Juvenile-Onset Still Disease1CTD_human
HgeneNRG1C0162351Contact hypersensitivity1CTD_human
HgeneNRG1C0234230Pain, Burning1CTD_human
HgeneNRG1C0234238Ache1CTD_human
HgeneNRG1C0234254Radiating pain1CTD_human
HgeneNRG1C0235527Heart Failure, Right-Sided1CTD_human
HgeneNRG1C0236733Amphetamine-Related Disorders1CTD_human
HgeneNRG1C0236804Amphetamine Addiction1CTD_human
HgeneNRG1C0236807Amphetamine Abuse1CTD_human
HgeneNRG1C0242379Malignant neoplasm of lung1CTD_human
HgeneNRG1C0266487Etat Marbre1CTD_human
HgeneNRG1C0458257Pain, Splitting1CTD_human
HgeneNRG1C0458259Pain, Crushing1CTD_human
HgeneNRG1C0678222Breast Carcinoma1CTD_human
HgeneNRG1C0751407Pain, Migratory1CTD_human
HgeneNRG1C0751408Suffering, Physical1CTD_human
HgeneNRG1C0876994Cardiotoxicity1CTD_human
HgeneNRG1C1136382Sclerocystic Ovaries1CTD_human
HgeneNRG1C1257840Aganglionosis, Rectosigmoid Colon1CTD_human
HgeneNRG1C1257931Mammary Neoplasms, Human1CTD_human
HgeneNRG1C1458155Mammary Neoplasms1CTD_human
HgeneNRG1C1959583Myocardial Failure1CTD_human
HgeneNRG1C1961112Heart Decompensation1CTD_human
HgeneNRG1C3495559Juvenile arthritis1CTD_human
HgeneNRG1C3661523Congenital Intestinal Aganglionosis1CTD_human
HgeneNRG1C3714758Juvenile psoriatic arthritis1CTD_human
HgeneNRG1C4552091Polyarthritis, Juvenile, Rheumatoid Factor Negative1CTD_human
HgeneNRG1C4704862Polyarthritis, Juvenile, Rheumatoid Factor Positive1CTD_human
HgeneNRG1C4704874Mammary Carcinoma, Human1CTD_human