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Center for Computational Systems Medicine level1
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:NUP214-CACNA1B

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: NUP214-CACNA1B
FusionPDB ID: 61038
FusionGDB2.0 ID: 61038
HgeneTgene
Gene symbol

NUP214

CACNA1B

Gene ID

8021

774

Gene namenucleoporin 214calcium voltage-gated channel subunit alpha1 B
SynonymsCAIN|CAN|IIAE9BIII|CACNL1A5|CACNN|Cav2.2|DYT23|NEDNEH
Cytomap

9q34.13

9q34.3

Type of geneprotein-codingprotein-coding
Descriptionnuclear pore complex protein Nup214CAN protein, putative oncogenenucleoporin 214kDavoltage-dependent N-type calcium channel subunit alpha-1BCav2.2 voltage-gated Ca2+ channelbrain calcium channel IIIcalcium channel alpha12.2 subunitcalcium channel, L type, alpha-1 polypeptidecalcium channel, voltage-dependent, L type, alpha 1B subun
Modification date2020032220200313
UniProtAcc

P35658

Q00975

Ensembl transtripts involved in fusion geneENST idsENST00000359428, ENST00000411637, 
ENST00000451030, ENST00000465486, 
ENST00000483497, 		ENST00000371365, 
ENST00000277550, ENST00000371367, 
ENST00000545473, ENST00000277549, 
ENST00000277551, ENST00000371355, 
ENST00000371357, ENST00000371363, 
ENST00000371372, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score11 X 15 X 5=8257 X 8 X 4=224
# samples 147
** MAII scorelog2(14/825*10)=-2.55896729218821
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(7/224*10)=-1.67807190511264
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: NUP214 [Title/Abstract] AND CACNA1B [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)NUP214(134039531)-CACNA1B(141006850), # samples:2
Anticipated loss of major functional domain due to fusion event.NUP214-CACNA1B seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
NUP214-CACNA1B seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
NUP214-CACNA1B seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
NUP214-CACNA1B seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneCACNA1B

GO:0050804

modulation of chemical synaptic transmission

23376566

TgeneCACNA1B

GO:1904645

response to amyloid-beta

23376566


check buttonFusion gene breakpoints across NUP214 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across CACNA1B (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4OVTCGA-24-1849-01ANUP214chr9

134039531

+CACNA1Bchr9

141006850

+


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000359428NUP214chr9134039531+ENST00000277551CACNA1Bchr9141006850+462230372143221433
ENST00000359428NUP214chr9134039531+ENST00000371372CACNA1Bchr9141006850+725430372146281535
ENST00000359428NUP214chr9134039531+ENST00000277549CACNA1Bchr9141006850+725430372146281535
ENST00000359428NUP214chr9134039531+ENST00000371363CACNA1Bchr9141006850+725430372146281535
ENST00000359428NUP214chr9134039531+ENST00000371355CACNA1Bchr9141006850+725430372146281535
ENST00000359428NUP214chr9134039531+ENST00000371357CACNA1Bchr9141006850+725430372146281535
ENST00000411637NUP214chr9134039531+ENST00000277551CACNA1Bchr9141006850+45672982842671419
ENST00000411637NUP214chr9134039531+ENST00000371372CACNA1Bchr9141006850+71992982845731521
ENST00000411637NUP214chr9134039531+ENST00000277549CACNA1Bchr9141006850+71992982845731521
ENST00000411637NUP214chr9134039531+ENST00000371363CACNA1Bchr9141006850+71992982845731521
ENST00000411637NUP214chr9134039531+ENST00000371355CACNA1Bchr9141006850+71992982845731521
ENST00000411637NUP214chr9134039531+ENST00000371357CACNA1Bchr9141006850+71992982845731521
ENST00000451030NUP214chr9134039531+ENST00000277551CACNA1Bchr9141006850+45923007042921430
ENST00000451030NUP214chr9134039531+ENST00000371372CACNA1Bchr9141006850+72243007045981532
ENST00000451030NUP214chr9134039531+ENST00000277549CACNA1Bchr9141006850+72243007045981532
ENST00000451030NUP214chr9134039531+ENST00000371363CACNA1Bchr9141006850+72243007045981532
ENST00000451030NUP214chr9134039531+ENST00000371355CACNA1Bchr9141006850+72243007045981532
ENST00000451030NUP214chr9134039531+ENST00000371357CACNA1Bchr9141006850+72243007045981532

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000359428ENST00000277551NUP214chr9134039531+CACNA1Bchr9141006850+0.0018420460.9981579
ENST00000359428ENST00000371372NUP214chr9134039531+CACNA1Bchr9141006850+0.0010900320.99890995
ENST00000359428ENST00000277549NUP214chr9134039531+CACNA1Bchr9141006850+0.0010900320.99890995
ENST00000359428ENST00000371363NUP214chr9134039531+CACNA1Bchr9141006850+0.0010900320.99890995
ENST00000359428ENST00000371355NUP214chr9134039531+CACNA1Bchr9141006850+0.0010900320.99890995
ENST00000359428ENST00000371357NUP214chr9134039531+CACNA1Bchr9141006850+0.0010900320.99890995
ENST00000411637ENST00000277551NUP214chr9134039531+CACNA1Bchr9141006850+0.0013391390.9986608
ENST00000411637ENST00000371372NUP214chr9134039531+CACNA1Bchr9141006850+0.0019123940.9980876
ENST00000411637ENST00000277549NUP214chr9134039531+CACNA1Bchr9141006850+0.0019123940.9980876
ENST00000411637ENST00000371363NUP214chr9134039531+CACNA1Bchr9141006850+0.0019123940.9980876
ENST00000411637ENST00000371355NUP214chr9134039531+CACNA1Bchr9141006850+0.0019123940.9980876
ENST00000411637ENST00000371357NUP214chr9134039531+CACNA1Bchr9141006850+0.0019123940.9980876
ENST00000451030ENST00000277551NUP214chr9134039531+CACNA1Bchr9141006850+0.0018762670.9981237
ENST00000451030ENST00000371372NUP214chr9134039531+CACNA1Bchr9141006850+0.0012519620.99874806
ENST00000451030ENST00000277549NUP214chr9134039531+CACNA1Bchr9141006850+0.0012519620.99874806
ENST00000451030ENST00000371363NUP214chr9134039531+CACNA1Bchr9141006850+0.0012519620.99874806
ENST00000451030ENST00000371355NUP214chr9134039531+CACNA1Bchr9141006850+0.0012519620.99874806
ENST00000451030ENST00000371357NUP214chr9134039531+CACNA1Bchr9141006850+0.0012519620.99874806

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>61038_61038_1_NUP214-CACNA1B_NUP214_chr9_134039531_ENST00000359428_CACNA1B_chr9_141006850_ENST00000277549_length(amino acids)=1535AA_BP=1005
MRGQLRAAGAEGRKFAVERPGFRGQGRGRQRWLLRHTEGGAMGDEMDAMIPEREMKDFQFRALKKVRIFDSPEELPKERSSLLAVSNKYG
LVFAGGASGLQIFPTKNLLIQNKPGDDPNKIVDKVQGLLVPMKFPIHHLALSCDNLTLSACMMSSEYGSIIAFFDVRTFSNEAKQQKRPF
AYHKLLKDAGGMVIDMKWNPTVPSMVAVCLADGSIAVLQVTETVKVCATLPSTVAVTSVCWSPKGKQLAVGKQNGTVVQYLPTLQEKKVI
PCPPFYESDHPVRVLDVLWIGTYVFAIVYAAADGTLETSPDVVMALLPKKEEKHPEIFVNFMEPCYGSCTERQHHYYLSYIEEWDLVLAA
SAASTEVSILARQSDQINWESWLLEDSSRAELPVTDKSDDSLPMGVVVDYTNQVEITISDEKTLPPAPVLMLLSTDGVLCPFYMINQNPG
VKSLIKTPERLSLEGERQPKSPGSTPTTPTSSQAPQKLDASAAAAPASLPPSSPAAPIATFSLLPAGGAPTVFSFGSSSLKSSATVTGEP
PSYSSGSDSSKAAPGPGPSTFSFVPPSKASLAPTPAASPVAPSAASFSFGSSGFKPTLESTPVPSVSAPNIAMKPSFPPSTSAVKVNLSE
KFTAAATSTPVSSSQSAPPMSPFSSASKPAASGPLSHPTPLSAPPSSVPLKSSVLPSPSGRSAQGSSSPVPSMVQKSPRITPPAAKPGSP
QAKSLQPAVAEKQGHQWKDSDPVMAGIGEEIAHFQKELEELKARTSKACFQVGTSEEMKMLRTESDDLHTFLLEIKETTESLHGDISSLK
TTLLEGFAGVEEAREQNERNRDSGYLHLLYKRPLDPKSEAQLQEIRRLHQYVKFAVQDVNDVLDLEWDQHLEQKKKQRHLLVPERETLFN
TLANNREIINQQRKRLNHLVDSLQQLRLYKQTSLWSLSSAVPSQSSIHSFDSDLESLCNALLKTTIESHTKSLPKVPAKLSPMKQAQLRN
FLAKRKTPPVRSTAPAGTKQHQCDAELRKEISVVWANLPQKTLDLLVPPHKPDEMTVGKVYAALMIFDFYKQNKTTRDQMQQAPGGLSQM
GPVSLFHPLKATLEQTQPAVLRGARVFLRQKSSTSLSNGGAIQNQESGIKESVSWGTQRTQDAPHEARPPLERGHSTEIPVGRSGALAVD
VQMQSITRRGPDGEPQPGLESQGRAASMPRLAAETQPVTDASPMKRSISTLAQRPRGTHLCSTTPDRPPPSQASSHHHHHRCHRRRDRKQ
RSLEKGPSLSADMDGAPSSAVGPGLPPGEGPTGCRRERERRQERGRSQERRQPSSSSSEKQRFYSCDRFGGREPPKPKPSLSSHPTSPTA
GQEPGPHPQGSGSVNGSPLLSTSGASTPGRGGRRQLPQTPLTPRPSITYKTANSSPIHFAGAQTSLPAFSPGRLSRGLSEHNALLQRDPL
SQPLAPGSRIGSDPYLGQRLDSEASVHALPEDTLTFEEAVATNSGRSSRTSYVSSLTSQSHPLRRVPNGYHCTLGLSSGGRARHSYHHPD

--------------------------------------------------------------

>61038_61038_2_NUP214-CACNA1B_NUP214_chr9_134039531_ENST00000359428_CACNA1B_chr9_141006850_ENST00000277551_length(amino acids)=1433AA_BP=1005
MRGQLRAAGAEGRKFAVERPGFRGQGRGRQRWLLRHTEGGAMGDEMDAMIPEREMKDFQFRALKKVRIFDSPEELPKERSSLLAVSNKYG
LVFAGGASGLQIFPTKNLLIQNKPGDDPNKIVDKVQGLLVPMKFPIHHLALSCDNLTLSACMMSSEYGSIIAFFDVRTFSNEAKQQKRPF
AYHKLLKDAGGMVIDMKWNPTVPSMVAVCLADGSIAVLQVTETVKVCATLPSTVAVTSVCWSPKGKQLAVGKQNGTVVQYLPTLQEKKVI
PCPPFYESDHPVRVLDVLWIGTYVFAIVYAAADGTLETSPDVVMALLPKKEEKHPEIFVNFMEPCYGSCTERQHHYYLSYIEEWDLVLAA
SAASTEVSILARQSDQINWESWLLEDSSRAELPVTDKSDDSLPMGVVVDYTNQVEITISDEKTLPPAPVLMLLSTDGVLCPFYMINQNPG
VKSLIKTPERLSLEGERQPKSPGSTPTTPTSSQAPQKLDASAAAAPASLPPSSPAAPIATFSLLPAGGAPTVFSFGSSSLKSSATVTGEP
PSYSSGSDSSKAAPGPGPSTFSFVPPSKASLAPTPAASPVAPSAASFSFGSSGFKPTLESTPVPSVSAPNIAMKPSFPPSTSAVKVNLSE
KFTAAATSTPVSSSQSAPPMSPFSSASKPAASGPLSHPTPLSAPPSSVPLKSSVLPSPSGRSAQGSSSPVPSMVQKSPRITPPAAKPGSP
QAKSLQPAVAEKQGHQWKDSDPVMAGIGEEIAHFQKELEELKARTSKACFQVGTSEEMKMLRTESDDLHTFLLEIKETTESLHGDISSLK
TTLLEGFAGVEEAREQNERNRDSGYLHLLYKRPLDPKSEAQLQEIRRLHQYVKFAVQDVNDVLDLEWDQHLEQKKKQRHLLVPERETLFN
TLANNREIINQQRKRLNHLVDSLQQLRLYKQTSLWSLSSAVPSQSSIHSFDSDLESLCNALLKTTIESHTKSLPKVPAKLSPMKQAQLRN
FLAKRKTPPVRSTAPAGTKQHQCDAELRKEISVVWANLPQKTLDLLVPPHKPDEMTVGKVYAALMIFDFYKQNKTTRDQMQQAPGGLSQM
GPVSLFHPLKATLEQTQPAVLRGARVFLRQKSSTSLSNGGAIQNQESGIKESVSWGTQRTQDAPHEARPPLERGHSTEIPVGRSGALAVD
VQMQSITRRGPDGEPQPGLESQGRAASMPRLAAETQPVTDASPMKRSISTLAQRPRGTHLCSTTPDRPPPSQASSHHHHHRCHRRRDRKQ
RSLEKGPSLSADMDGAPSSAVGPGLPPGEGPTGCRRERERRQERGRSQERRQPSSSSSEKQRFYSCDRFGGREPPKPKPSLSSHPTSPTA

--------------------------------------------------------------

>61038_61038_3_NUP214-CACNA1B_NUP214_chr9_134039531_ENST00000359428_CACNA1B_chr9_141006850_ENST00000371355_length(amino acids)=1535AA_BP=1005
MRGQLRAAGAEGRKFAVERPGFRGQGRGRQRWLLRHTEGGAMGDEMDAMIPEREMKDFQFRALKKVRIFDSPEELPKERSSLLAVSNKYG
LVFAGGASGLQIFPTKNLLIQNKPGDDPNKIVDKVQGLLVPMKFPIHHLALSCDNLTLSACMMSSEYGSIIAFFDVRTFSNEAKQQKRPF
AYHKLLKDAGGMVIDMKWNPTVPSMVAVCLADGSIAVLQVTETVKVCATLPSTVAVTSVCWSPKGKQLAVGKQNGTVVQYLPTLQEKKVI
PCPPFYESDHPVRVLDVLWIGTYVFAIVYAAADGTLETSPDVVMALLPKKEEKHPEIFVNFMEPCYGSCTERQHHYYLSYIEEWDLVLAA
SAASTEVSILARQSDQINWESWLLEDSSRAELPVTDKSDDSLPMGVVVDYTNQVEITISDEKTLPPAPVLMLLSTDGVLCPFYMINQNPG
VKSLIKTPERLSLEGERQPKSPGSTPTTPTSSQAPQKLDASAAAAPASLPPSSPAAPIATFSLLPAGGAPTVFSFGSSSLKSSATVTGEP
PSYSSGSDSSKAAPGPGPSTFSFVPPSKASLAPTPAASPVAPSAASFSFGSSGFKPTLESTPVPSVSAPNIAMKPSFPPSTSAVKVNLSE
KFTAAATSTPVSSSQSAPPMSPFSSASKPAASGPLSHPTPLSAPPSSVPLKSSVLPSPSGRSAQGSSSPVPSMVQKSPRITPPAAKPGSP
QAKSLQPAVAEKQGHQWKDSDPVMAGIGEEIAHFQKELEELKARTSKACFQVGTSEEMKMLRTESDDLHTFLLEIKETTESLHGDISSLK
TTLLEGFAGVEEAREQNERNRDSGYLHLLYKRPLDPKSEAQLQEIRRLHQYVKFAVQDVNDVLDLEWDQHLEQKKKQRHLLVPERETLFN
TLANNREIINQQRKRLNHLVDSLQQLRLYKQTSLWSLSSAVPSQSSIHSFDSDLESLCNALLKTTIESHTKSLPKVPAKLSPMKQAQLRN
FLAKRKTPPVRSTAPAGTKQHQCDAELRKEISVVWANLPQKTLDLLVPPHKPDEMTVGKVYAALMIFDFYKQNKTTRDQMQQAPGGLSQM
GPVSLFHPLKATLEQTQPAVLRGARVFLRQKSSTSLSNGGAIQNQESGIKESVSWGTQRTQDAPHEARPPLERGHSTEIPVGRSGALAVD
VQMQSITRRGPDGEPQPGLESQGRAASMPRLAAETQPVTDASPMKRSISTLAQRPRGTHLCSTTPDRPPPSQASSHHHHHRCHRRRDRKQ
RSLEKGPSLSADMDGAPSSAVGPGLPPGEGPTGCRRERERRQERGRSQERRQPSSSSSEKQRFYSCDRFGGREPPKPKPSLSSHPTSPTA
GQEPGPHPQGSGSVNGSPLLSTSGASTPGRGGRRQLPQTPLTPRPSITYKTANSSPIHFAGAQTSLPAFSPGRLSRGLSEHNALLQRDPL
SQPLAPGSRIGSDPYLGQRLDSEASVHALPEDTLTFEEAVATNSGRSSRTSYVSSLTSQSHPLRRVPNGYHCTLGLSSGGRARHSYHHPD

--------------------------------------------------------------

>61038_61038_4_NUP214-CACNA1B_NUP214_chr9_134039531_ENST00000359428_CACNA1B_chr9_141006850_ENST00000371357_length(amino acids)=1535AA_BP=1005
MRGQLRAAGAEGRKFAVERPGFRGQGRGRQRWLLRHTEGGAMGDEMDAMIPEREMKDFQFRALKKVRIFDSPEELPKERSSLLAVSNKYG
LVFAGGASGLQIFPTKNLLIQNKPGDDPNKIVDKVQGLLVPMKFPIHHLALSCDNLTLSACMMSSEYGSIIAFFDVRTFSNEAKQQKRPF
AYHKLLKDAGGMVIDMKWNPTVPSMVAVCLADGSIAVLQVTETVKVCATLPSTVAVTSVCWSPKGKQLAVGKQNGTVVQYLPTLQEKKVI
PCPPFYESDHPVRVLDVLWIGTYVFAIVYAAADGTLETSPDVVMALLPKKEEKHPEIFVNFMEPCYGSCTERQHHYYLSYIEEWDLVLAA
SAASTEVSILARQSDQINWESWLLEDSSRAELPVTDKSDDSLPMGVVVDYTNQVEITISDEKTLPPAPVLMLLSTDGVLCPFYMINQNPG
VKSLIKTPERLSLEGERQPKSPGSTPTTPTSSQAPQKLDASAAAAPASLPPSSPAAPIATFSLLPAGGAPTVFSFGSSSLKSSATVTGEP
PSYSSGSDSSKAAPGPGPSTFSFVPPSKASLAPTPAASPVAPSAASFSFGSSGFKPTLESTPVPSVSAPNIAMKPSFPPSTSAVKVNLSE
KFTAAATSTPVSSSQSAPPMSPFSSASKPAASGPLSHPTPLSAPPSSVPLKSSVLPSPSGRSAQGSSSPVPSMVQKSPRITPPAAKPGSP
QAKSLQPAVAEKQGHQWKDSDPVMAGIGEEIAHFQKELEELKARTSKACFQVGTSEEMKMLRTESDDLHTFLLEIKETTESLHGDISSLK
TTLLEGFAGVEEAREQNERNRDSGYLHLLYKRPLDPKSEAQLQEIRRLHQYVKFAVQDVNDVLDLEWDQHLEQKKKQRHLLVPERETLFN
TLANNREIINQQRKRLNHLVDSLQQLRLYKQTSLWSLSSAVPSQSSIHSFDSDLESLCNALLKTTIESHTKSLPKVPAKLSPMKQAQLRN
FLAKRKTPPVRSTAPAGTKQHQCDAELRKEISVVWANLPQKTLDLLVPPHKPDEMTVGKVYAALMIFDFYKQNKTTRDQMQQAPGGLSQM
GPVSLFHPLKATLEQTQPAVLRGARVFLRQKSSTSLSNGGAIQNQESGIKESVSWGTQRTQDAPHEARPPLERGHSTEIPVGRSGALAVD
VQMQSITRRGPDGEPQPGLESQGRAASMPRLAAETQPVTDASPMKRSISTLAQRPRGTHLCSTTPDRPPPSQASSHHHHHRCHRRRDRKQ
RSLEKGPSLSADMDGAPSSAVGPGLPPGEGPTGCRRERERRQERGRSQERRQPSSSSSEKQRFYSCDRFGGREPPKPKPSLSSHPTSPTA
GQEPGPHPQGSGSVNGSPLLSTSGASTPGRGGRRQLPQTPLTPRPSITYKTANSSPIHFAGAQTSLPAFSPGRLSRGLSEHNALLQRDPL
SQPLAPGSRIGSDPYLGQRLDSEASVHALPEDTLTFEEAVATNSGRSSRTSYVSSLTSQSHPLRRVPNGYHCTLGLSSGGRARHSYHHPD

--------------------------------------------------------------

>61038_61038_5_NUP214-CACNA1B_NUP214_chr9_134039531_ENST00000359428_CACNA1B_chr9_141006850_ENST00000371363_length(amino acids)=1535AA_BP=1005
MRGQLRAAGAEGRKFAVERPGFRGQGRGRQRWLLRHTEGGAMGDEMDAMIPEREMKDFQFRALKKVRIFDSPEELPKERSSLLAVSNKYG
LVFAGGASGLQIFPTKNLLIQNKPGDDPNKIVDKVQGLLVPMKFPIHHLALSCDNLTLSACMMSSEYGSIIAFFDVRTFSNEAKQQKRPF
AYHKLLKDAGGMVIDMKWNPTVPSMVAVCLADGSIAVLQVTETVKVCATLPSTVAVTSVCWSPKGKQLAVGKQNGTVVQYLPTLQEKKVI
PCPPFYESDHPVRVLDVLWIGTYVFAIVYAAADGTLETSPDVVMALLPKKEEKHPEIFVNFMEPCYGSCTERQHHYYLSYIEEWDLVLAA
SAASTEVSILARQSDQINWESWLLEDSSRAELPVTDKSDDSLPMGVVVDYTNQVEITISDEKTLPPAPVLMLLSTDGVLCPFYMINQNPG
VKSLIKTPERLSLEGERQPKSPGSTPTTPTSSQAPQKLDASAAAAPASLPPSSPAAPIATFSLLPAGGAPTVFSFGSSSLKSSATVTGEP
PSYSSGSDSSKAAPGPGPSTFSFVPPSKASLAPTPAASPVAPSAASFSFGSSGFKPTLESTPVPSVSAPNIAMKPSFPPSTSAVKVNLSE
KFTAAATSTPVSSSQSAPPMSPFSSASKPAASGPLSHPTPLSAPPSSVPLKSSVLPSPSGRSAQGSSSPVPSMVQKSPRITPPAAKPGSP
QAKSLQPAVAEKQGHQWKDSDPVMAGIGEEIAHFQKELEELKARTSKACFQVGTSEEMKMLRTESDDLHTFLLEIKETTESLHGDISSLK
TTLLEGFAGVEEAREQNERNRDSGYLHLLYKRPLDPKSEAQLQEIRRLHQYVKFAVQDVNDVLDLEWDQHLEQKKKQRHLLVPERETLFN
TLANNREIINQQRKRLNHLVDSLQQLRLYKQTSLWSLSSAVPSQSSIHSFDSDLESLCNALLKTTIESHTKSLPKVPAKLSPMKQAQLRN
FLAKRKTPPVRSTAPAGTKQHQCDAELRKEISVVWANLPQKTLDLLVPPHKPDEMTVGKVYAALMIFDFYKQNKTTRDQMQQAPGGLSQM
GPVSLFHPLKATLEQTQPAVLRGARVFLRQKSSTSLSNGGAIQNQESGIKESVSWGTQRTQDAPHEARPPLERGHSTEIPVGRSGALAVD
VQMQSITRRGPDGEPQPGLESQGRAASMPRLAAETQPVTDASPMKRSISTLAQRPRGTHLCSTTPDRPPPSQASSHHHHHRCHRRRDRKQ
RSLEKGPSLSADMDGAPSSAVGPGLPPGEGPTGCRRERERRQERGRSQERRQPSSSSSEKQRFYSCDRFGGREPPKPKPSLSSHPTSPTA
GQEPGPHPQGSGSVNGSPLLSTSGASTPGRGGRRQLPQTPLTPRPSITYKTANSSPIHFAGAQTSLPAFSPGRLSRGLSEHNALLQRDPL
SQPLAPGSRIGSDPYLGQRLDSEASVHALPEDTLTFEEAVATNSGRSSRTSYVSSLTSQSHPLRRVPNGYHCTLGLSSGGRARHSYHHPD

--------------------------------------------------------------

>61038_61038_6_NUP214-CACNA1B_NUP214_chr9_134039531_ENST00000359428_CACNA1B_chr9_141006850_ENST00000371372_length(amino acids)=1535AA_BP=1005
MRGQLRAAGAEGRKFAVERPGFRGQGRGRQRWLLRHTEGGAMGDEMDAMIPEREMKDFQFRALKKVRIFDSPEELPKERSSLLAVSNKYG
LVFAGGASGLQIFPTKNLLIQNKPGDDPNKIVDKVQGLLVPMKFPIHHLALSCDNLTLSACMMSSEYGSIIAFFDVRTFSNEAKQQKRPF
AYHKLLKDAGGMVIDMKWNPTVPSMVAVCLADGSIAVLQVTETVKVCATLPSTVAVTSVCWSPKGKQLAVGKQNGTVVQYLPTLQEKKVI
PCPPFYESDHPVRVLDVLWIGTYVFAIVYAAADGTLETSPDVVMALLPKKEEKHPEIFVNFMEPCYGSCTERQHHYYLSYIEEWDLVLAA
SAASTEVSILARQSDQINWESWLLEDSSRAELPVTDKSDDSLPMGVVVDYTNQVEITISDEKTLPPAPVLMLLSTDGVLCPFYMINQNPG
VKSLIKTPERLSLEGERQPKSPGSTPTTPTSSQAPQKLDASAAAAPASLPPSSPAAPIATFSLLPAGGAPTVFSFGSSSLKSSATVTGEP
PSYSSGSDSSKAAPGPGPSTFSFVPPSKASLAPTPAASPVAPSAASFSFGSSGFKPTLESTPVPSVSAPNIAMKPSFPPSTSAVKVNLSE
KFTAAATSTPVSSSQSAPPMSPFSSASKPAASGPLSHPTPLSAPPSSVPLKSSVLPSPSGRSAQGSSSPVPSMVQKSPRITPPAAKPGSP
QAKSLQPAVAEKQGHQWKDSDPVMAGIGEEIAHFQKELEELKARTSKACFQVGTSEEMKMLRTESDDLHTFLLEIKETTESLHGDISSLK
TTLLEGFAGVEEAREQNERNRDSGYLHLLYKRPLDPKSEAQLQEIRRLHQYVKFAVQDVNDVLDLEWDQHLEQKKKQRHLLVPERETLFN
TLANNREIINQQRKRLNHLVDSLQQLRLYKQTSLWSLSSAVPSQSSIHSFDSDLESLCNALLKTTIESHTKSLPKVPAKLSPMKQAQLRN
FLAKRKTPPVRSTAPAGTKQHQCDAELRKEISVVWANLPQKTLDLLVPPHKPDEMTVGKVYAALMIFDFYKQNKTTRDQMQQAPGGLSQM
GPVSLFHPLKATLEQTQPAVLRGARVFLRQKSSTSLSNGGAIQNQESGIKESVSWGTQRTQDAPHEARPPLERGHSTEIPVGRSGALAVD
VQMQSITRRGPDGEPQPGLESQGRAASMPRLAAETQPVTDASPMKRSISTLAQRPRGTHLCSTTPDRPPPSQASSHHHHHRCHRRRDRKQ
RSLEKGPSLSADMDGAPSSAVGPGLPPGEGPTGCRRERERRQERGRSQERRQPSSSSSEKQRFYSCDRFGGREPPKPKPSLSSHPTSPTA
GQEPGPHPQGSGSVNGSPLLSTSGASTPGRGGRRQLPQTPLTPRPSITYKTANSSPIHFAGAQTSLPAFSPGRLSRGLSEHNALLQRDPL
SQPLAPGSRIGSDPYLGQRLDSEASVHALPEDTLTFEEAVATNSGRSSRTSYVSSLTSQSHPLRRVPNGYHCTLGLSSGGRARHSYHHPD

--------------------------------------------------------------

>61038_61038_7_NUP214-CACNA1B_NUP214_chr9_134039531_ENST00000411637_CACNA1B_chr9_141006850_ENST00000277549_length(amino acids)=1521AA_BP=991
MRAAGAEGRKFAVERPGFRGQGRGRQRWLLRHTEGGAMGDEMDAMIPEREMKDFQFRALKKVRIFDSPEELPKERSSLLAVSNKYGLVFA
GGASGLQIFPTKNLLIQNKPGDDPNKIVDKVQGLLVPMKFPIHHLALSCDNLTLSACMMSSEYGSIIAFFDVRTFSNEAKQQKRPFAYHK
LLKDAGGMVIDMKWNPTVPSMVAVCLADGSIAVLQVTETVKVCATLPSTVAVTSVCWSPKGKQLAVGKQNGTVVQYLPTLQEKKVIPCPP
FYESDHPVRVLDVLWIGTYVFAIVYAAADGTLETSPDVVMALLPKKEEKHPEIFVNFMEPCYGSCTERQHHYYLSYIEEWDLVLAASAAS
TEVSILARQSDQINWESWLLEDSSRAELPVTDKSDDSLPMGVVVDYTNQVEITISDEKTLPPAPVLMLLSTDGVLCPFYMINQNPGVKSL
IKTPERLSLEGERQPKSPGSTPTTPTSSQAPQKLDASAAAAPASLPPSSPAAPIATFSLLPAGGAPTVFSFGSSSLKSSATVTGEPPSYS
SGSDSSKAAPGPGPSTFSFVPPSKASLAPTPAASPVAPSAASFSFGSSGFKPTLESTPVPSVSAPNIAMKPSFPPSTSAVKVNLSENSSQ
SAPPMSPFSSASKPAASGPLSHPTPLSAPPSSVPLKSSVLPSPSAGRSAQGSSSPVPSMVQKSPRITPPAAKPGSPQAKSLQPAVAEKQG
HQWKDSDPVMAGIGEEIAHFQKELEELKARTSKACFQVGTSEEMKMLRTESDDLHTFLLEIKETTESLHGDISSLKTTLLEGFAGVEEAR
EQNERNRDSGYLHLLYKRPLDPKSEAQLQEIRRLHQYVKFAVQDVNDVLDLEWDQHLEQKKKQRHLLVPERETLFNTLANNREIINQQRK
RLNHLVDSLQQLRLYKQTSLWSLSSAVPSQSSIHSFDSDLESLCNALLKTTIESHTKSLPKVPAKLSPMKQAQLRNFLAKRKTPPVRSTA
PAGTKQHQCDAELRKEISVVWANLPQKTLDLLVPPHKPDEMTVGKVYAALMIFDFYKQNKTTRDQMQQAPGGLSQMGPVSLFHPLKATLE
QTQPAVLRGARVFLRQKSSTSLSNGGAIQNQESGIKESVSWGTQRTQDAPHEARPPLERGHSTEIPVGRSGALAVDVQMQSITRRGPDGE
PQPGLESQGRAASMPRLAAETQPVTDASPMKRSISTLAQRPRGTHLCSTTPDRPPPSQASSHHHHHRCHRRRDRKQRSLEKGPSLSADMD
GAPSSAVGPGLPPGEGPTGCRRERERRQERGRSQERRQPSSSSSEKQRFYSCDRFGGREPPKPKPSLSSHPTSPTAGQEPGPHPQGSGSV
NGSPLLSTSGASTPGRGGRRQLPQTPLTPRPSITYKTANSSPIHFAGAQTSLPAFSPGRLSRGLSEHNALLQRDPLSQPLAPGSRIGSDP

--------------------------------------------------------------

>61038_61038_8_NUP214-CACNA1B_NUP214_chr9_134039531_ENST00000411637_CACNA1B_chr9_141006850_ENST00000277551_length(amino acids)=1419AA_BP=991
MRAAGAEGRKFAVERPGFRGQGRGRQRWLLRHTEGGAMGDEMDAMIPEREMKDFQFRALKKVRIFDSPEELPKERSSLLAVSNKYGLVFA
GGASGLQIFPTKNLLIQNKPGDDPNKIVDKVQGLLVPMKFPIHHLALSCDNLTLSACMMSSEYGSIIAFFDVRTFSNEAKQQKRPFAYHK
LLKDAGGMVIDMKWNPTVPSMVAVCLADGSIAVLQVTETVKVCATLPSTVAVTSVCWSPKGKQLAVGKQNGTVVQYLPTLQEKKVIPCPP
FYESDHPVRVLDVLWIGTYVFAIVYAAADGTLETSPDVVMALLPKKEEKHPEIFVNFMEPCYGSCTERQHHYYLSYIEEWDLVLAASAAS
TEVSILARQSDQINWESWLLEDSSRAELPVTDKSDDSLPMGVVVDYTNQVEITISDEKTLPPAPVLMLLSTDGVLCPFYMINQNPGVKSL
IKTPERLSLEGERQPKSPGSTPTTPTSSQAPQKLDASAAAAPASLPPSSPAAPIATFSLLPAGGAPTVFSFGSSSLKSSATVTGEPPSYS
SGSDSSKAAPGPGPSTFSFVPPSKASLAPTPAASPVAPSAASFSFGSSGFKPTLESTPVPSVSAPNIAMKPSFPPSTSAVKVNLSENSSQ
SAPPMSPFSSASKPAASGPLSHPTPLSAPPSSVPLKSSVLPSPSAGRSAQGSSSPVPSMVQKSPRITPPAAKPGSPQAKSLQPAVAEKQG
HQWKDSDPVMAGIGEEIAHFQKELEELKARTSKACFQVGTSEEMKMLRTESDDLHTFLLEIKETTESLHGDISSLKTTLLEGFAGVEEAR
EQNERNRDSGYLHLLYKRPLDPKSEAQLQEIRRLHQYVKFAVQDVNDVLDLEWDQHLEQKKKQRHLLVPERETLFNTLANNREIINQQRK
RLNHLVDSLQQLRLYKQTSLWSLSSAVPSQSSIHSFDSDLESLCNALLKTTIESHTKSLPKVPAKLSPMKQAQLRNFLAKRKTPPVRSTA
PAGTKQHQCDAELRKEISVVWANLPQKTLDLLVPPHKPDEMTVGKVYAALMIFDFYKQNKTTRDQMQQAPGGLSQMGPVSLFHPLKATLE
QTQPAVLRGARVFLRQKSSTSLSNGGAIQNQESGIKESVSWGTQRTQDAPHEARPPLERGHSTEIPVGRSGALAVDVQMQSITRRGPDGE
PQPGLESQGRAASMPRLAAETQPVTDASPMKRSISTLAQRPRGTHLCSTTPDRPPPSQASSHHHHHRCHRRRDRKQRSLEKGPSLSADMD
GAPSSAVGPGLPPGEGPTGCRRERERRQERGRSQERRQPSSSSSEKQRFYSCDRFGGREPPKPKPSLSSHPTSPTAGQEPGPHPQAGSAV

--------------------------------------------------------------

>61038_61038_9_NUP214-CACNA1B_NUP214_chr9_134039531_ENST00000411637_CACNA1B_chr9_141006850_ENST00000371355_length(amino acids)=1521AA_BP=991
MRAAGAEGRKFAVERPGFRGQGRGRQRWLLRHTEGGAMGDEMDAMIPEREMKDFQFRALKKVRIFDSPEELPKERSSLLAVSNKYGLVFA
GGASGLQIFPTKNLLIQNKPGDDPNKIVDKVQGLLVPMKFPIHHLALSCDNLTLSACMMSSEYGSIIAFFDVRTFSNEAKQQKRPFAYHK
LLKDAGGMVIDMKWNPTVPSMVAVCLADGSIAVLQVTETVKVCATLPSTVAVTSVCWSPKGKQLAVGKQNGTVVQYLPTLQEKKVIPCPP
FYESDHPVRVLDVLWIGTYVFAIVYAAADGTLETSPDVVMALLPKKEEKHPEIFVNFMEPCYGSCTERQHHYYLSYIEEWDLVLAASAAS
TEVSILARQSDQINWESWLLEDSSRAELPVTDKSDDSLPMGVVVDYTNQVEITISDEKTLPPAPVLMLLSTDGVLCPFYMINQNPGVKSL
IKTPERLSLEGERQPKSPGSTPTTPTSSQAPQKLDASAAAAPASLPPSSPAAPIATFSLLPAGGAPTVFSFGSSSLKSSATVTGEPPSYS
SGSDSSKAAPGPGPSTFSFVPPSKASLAPTPAASPVAPSAASFSFGSSGFKPTLESTPVPSVSAPNIAMKPSFPPSTSAVKVNLSENSSQ
SAPPMSPFSSASKPAASGPLSHPTPLSAPPSSVPLKSSVLPSPSAGRSAQGSSSPVPSMVQKSPRITPPAAKPGSPQAKSLQPAVAEKQG
HQWKDSDPVMAGIGEEIAHFQKELEELKARTSKACFQVGTSEEMKMLRTESDDLHTFLLEIKETTESLHGDISSLKTTLLEGFAGVEEAR
EQNERNRDSGYLHLLYKRPLDPKSEAQLQEIRRLHQYVKFAVQDVNDVLDLEWDQHLEQKKKQRHLLVPERETLFNTLANNREIINQQRK
RLNHLVDSLQQLRLYKQTSLWSLSSAVPSQSSIHSFDSDLESLCNALLKTTIESHTKSLPKVPAKLSPMKQAQLRNFLAKRKTPPVRSTA
PAGTKQHQCDAELRKEISVVWANLPQKTLDLLVPPHKPDEMTVGKVYAALMIFDFYKQNKTTRDQMQQAPGGLSQMGPVSLFHPLKATLE
QTQPAVLRGARVFLRQKSSTSLSNGGAIQNQESGIKESVSWGTQRTQDAPHEARPPLERGHSTEIPVGRSGALAVDVQMQSITRRGPDGE
PQPGLESQGRAASMPRLAAETQPVTDASPMKRSISTLAQRPRGTHLCSTTPDRPPPSQASSHHHHHRCHRRRDRKQRSLEKGPSLSADMD
GAPSSAVGPGLPPGEGPTGCRRERERRQERGRSQERRQPSSSSSEKQRFYSCDRFGGREPPKPKPSLSSHPTSPTAGQEPGPHPQGSGSV
NGSPLLSTSGASTPGRGGRRQLPQTPLTPRPSITYKTANSSPIHFAGAQTSLPAFSPGRLSRGLSEHNALLQRDPLSQPLAPGSRIGSDP

--------------------------------------------------------------

>61038_61038_10_NUP214-CACNA1B_NUP214_chr9_134039531_ENST00000411637_CACNA1B_chr9_141006850_ENST00000371357_length(amino acids)=1521AA_BP=991
MRAAGAEGRKFAVERPGFRGQGRGRQRWLLRHTEGGAMGDEMDAMIPEREMKDFQFRALKKVRIFDSPEELPKERSSLLAVSNKYGLVFA
GGASGLQIFPTKNLLIQNKPGDDPNKIVDKVQGLLVPMKFPIHHLALSCDNLTLSACMMSSEYGSIIAFFDVRTFSNEAKQQKRPFAYHK
LLKDAGGMVIDMKWNPTVPSMVAVCLADGSIAVLQVTETVKVCATLPSTVAVTSVCWSPKGKQLAVGKQNGTVVQYLPTLQEKKVIPCPP
FYESDHPVRVLDVLWIGTYVFAIVYAAADGTLETSPDVVMALLPKKEEKHPEIFVNFMEPCYGSCTERQHHYYLSYIEEWDLVLAASAAS
TEVSILARQSDQINWESWLLEDSSRAELPVTDKSDDSLPMGVVVDYTNQVEITISDEKTLPPAPVLMLLSTDGVLCPFYMINQNPGVKSL
IKTPERLSLEGERQPKSPGSTPTTPTSSQAPQKLDASAAAAPASLPPSSPAAPIATFSLLPAGGAPTVFSFGSSSLKSSATVTGEPPSYS
SGSDSSKAAPGPGPSTFSFVPPSKASLAPTPAASPVAPSAASFSFGSSGFKPTLESTPVPSVSAPNIAMKPSFPPSTSAVKVNLSENSSQ
SAPPMSPFSSASKPAASGPLSHPTPLSAPPSSVPLKSSVLPSPSAGRSAQGSSSPVPSMVQKSPRITPPAAKPGSPQAKSLQPAVAEKQG
HQWKDSDPVMAGIGEEIAHFQKELEELKARTSKACFQVGTSEEMKMLRTESDDLHTFLLEIKETTESLHGDISSLKTTLLEGFAGVEEAR
EQNERNRDSGYLHLLYKRPLDPKSEAQLQEIRRLHQYVKFAVQDVNDVLDLEWDQHLEQKKKQRHLLVPERETLFNTLANNREIINQQRK
RLNHLVDSLQQLRLYKQTSLWSLSSAVPSQSSIHSFDSDLESLCNALLKTTIESHTKSLPKVPAKLSPMKQAQLRNFLAKRKTPPVRSTA
PAGTKQHQCDAELRKEISVVWANLPQKTLDLLVPPHKPDEMTVGKVYAALMIFDFYKQNKTTRDQMQQAPGGLSQMGPVSLFHPLKATLE
QTQPAVLRGARVFLRQKSSTSLSNGGAIQNQESGIKESVSWGTQRTQDAPHEARPPLERGHSTEIPVGRSGALAVDVQMQSITRRGPDGE
PQPGLESQGRAASMPRLAAETQPVTDASPMKRSISTLAQRPRGTHLCSTTPDRPPPSQASSHHHHHRCHRRRDRKQRSLEKGPSLSADMD
GAPSSAVGPGLPPGEGPTGCRRERERRQERGRSQERRQPSSSSSEKQRFYSCDRFGGREPPKPKPSLSSHPTSPTAGQEPGPHPQGSGSV
NGSPLLSTSGASTPGRGGRRQLPQTPLTPRPSITYKTANSSPIHFAGAQTSLPAFSPGRLSRGLSEHNALLQRDPLSQPLAPGSRIGSDP

--------------------------------------------------------------

>61038_61038_11_NUP214-CACNA1B_NUP214_chr9_134039531_ENST00000411637_CACNA1B_chr9_141006850_ENST00000371363_length(amino acids)=1521AA_BP=991
MRAAGAEGRKFAVERPGFRGQGRGRQRWLLRHTEGGAMGDEMDAMIPEREMKDFQFRALKKVRIFDSPEELPKERSSLLAVSNKYGLVFA
GGASGLQIFPTKNLLIQNKPGDDPNKIVDKVQGLLVPMKFPIHHLALSCDNLTLSACMMSSEYGSIIAFFDVRTFSNEAKQQKRPFAYHK
LLKDAGGMVIDMKWNPTVPSMVAVCLADGSIAVLQVTETVKVCATLPSTVAVTSVCWSPKGKQLAVGKQNGTVVQYLPTLQEKKVIPCPP
FYESDHPVRVLDVLWIGTYVFAIVYAAADGTLETSPDVVMALLPKKEEKHPEIFVNFMEPCYGSCTERQHHYYLSYIEEWDLVLAASAAS
TEVSILARQSDQINWESWLLEDSSRAELPVTDKSDDSLPMGVVVDYTNQVEITISDEKTLPPAPVLMLLSTDGVLCPFYMINQNPGVKSL
IKTPERLSLEGERQPKSPGSTPTTPTSSQAPQKLDASAAAAPASLPPSSPAAPIATFSLLPAGGAPTVFSFGSSSLKSSATVTGEPPSYS
SGSDSSKAAPGPGPSTFSFVPPSKASLAPTPAASPVAPSAASFSFGSSGFKPTLESTPVPSVSAPNIAMKPSFPPSTSAVKVNLSENSSQ
SAPPMSPFSSASKPAASGPLSHPTPLSAPPSSVPLKSSVLPSPSAGRSAQGSSSPVPSMVQKSPRITPPAAKPGSPQAKSLQPAVAEKQG
HQWKDSDPVMAGIGEEIAHFQKELEELKARTSKACFQVGTSEEMKMLRTESDDLHTFLLEIKETTESLHGDISSLKTTLLEGFAGVEEAR
EQNERNRDSGYLHLLYKRPLDPKSEAQLQEIRRLHQYVKFAVQDVNDVLDLEWDQHLEQKKKQRHLLVPERETLFNTLANNREIINQQRK
RLNHLVDSLQQLRLYKQTSLWSLSSAVPSQSSIHSFDSDLESLCNALLKTTIESHTKSLPKVPAKLSPMKQAQLRNFLAKRKTPPVRSTA
PAGTKQHQCDAELRKEISVVWANLPQKTLDLLVPPHKPDEMTVGKVYAALMIFDFYKQNKTTRDQMQQAPGGLSQMGPVSLFHPLKATLE
QTQPAVLRGARVFLRQKSSTSLSNGGAIQNQESGIKESVSWGTQRTQDAPHEARPPLERGHSTEIPVGRSGALAVDVQMQSITRRGPDGE
PQPGLESQGRAASMPRLAAETQPVTDASPMKRSISTLAQRPRGTHLCSTTPDRPPPSQASSHHHHHRCHRRRDRKQRSLEKGPSLSADMD
GAPSSAVGPGLPPGEGPTGCRRERERRQERGRSQERRQPSSSSSEKQRFYSCDRFGGREPPKPKPSLSSHPTSPTAGQEPGPHPQGSGSV
NGSPLLSTSGASTPGRGGRRQLPQTPLTPRPSITYKTANSSPIHFAGAQTSLPAFSPGRLSRGLSEHNALLQRDPLSQPLAPGSRIGSDP

--------------------------------------------------------------

>61038_61038_12_NUP214-CACNA1B_NUP214_chr9_134039531_ENST00000411637_CACNA1B_chr9_141006850_ENST00000371372_length(amino acids)=1521AA_BP=991
MRAAGAEGRKFAVERPGFRGQGRGRQRWLLRHTEGGAMGDEMDAMIPEREMKDFQFRALKKVRIFDSPEELPKERSSLLAVSNKYGLVFA
GGASGLQIFPTKNLLIQNKPGDDPNKIVDKVQGLLVPMKFPIHHLALSCDNLTLSACMMSSEYGSIIAFFDVRTFSNEAKQQKRPFAYHK
LLKDAGGMVIDMKWNPTVPSMVAVCLADGSIAVLQVTETVKVCATLPSTVAVTSVCWSPKGKQLAVGKQNGTVVQYLPTLQEKKVIPCPP
FYESDHPVRVLDVLWIGTYVFAIVYAAADGTLETSPDVVMALLPKKEEKHPEIFVNFMEPCYGSCTERQHHYYLSYIEEWDLVLAASAAS
TEVSILARQSDQINWESWLLEDSSRAELPVTDKSDDSLPMGVVVDYTNQVEITISDEKTLPPAPVLMLLSTDGVLCPFYMINQNPGVKSL
IKTPERLSLEGERQPKSPGSTPTTPTSSQAPQKLDASAAAAPASLPPSSPAAPIATFSLLPAGGAPTVFSFGSSSLKSSATVTGEPPSYS
SGSDSSKAAPGPGPSTFSFVPPSKASLAPTPAASPVAPSAASFSFGSSGFKPTLESTPVPSVSAPNIAMKPSFPPSTSAVKVNLSENSSQ
SAPPMSPFSSASKPAASGPLSHPTPLSAPPSSVPLKSSVLPSPSAGRSAQGSSSPVPSMVQKSPRITPPAAKPGSPQAKSLQPAVAEKQG
HQWKDSDPVMAGIGEEIAHFQKELEELKARTSKACFQVGTSEEMKMLRTESDDLHTFLLEIKETTESLHGDISSLKTTLLEGFAGVEEAR
EQNERNRDSGYLHLLYKRPLDPKSEAQLQEIRRLHQYVKFAVQDVNDVLDLEWDQHLEQKKKQRHLLVPERETLFNTLANNREIINQQRK
RLNHLVDSLQQLRLYKQTSLWSLSSAVPSQSSIHSFDSDLESLCNALLKTTIESHTKSLPKVPAKLSPMKQAQLRNFLAKRKTPPVRSTA
PAGTKQHQCDAELRKEISVVWANLPQKTLDLLVPPHKPDEMTVGKVYAALMIFDFYKQNKTTRDQMQQAPGGLSQMGPVSLFHPLKATLE
QTQPAVLRGARVFLRQKSSTSLSNGGAIQNQESGIKESVSWGTQRTQDAPHEARPPLERGHSTEIPVGRSGALAVDVQMQSITRRGPDGE
PQPGLESQGRAASMPRLAAETQPVTDASPMKRSISTLAQRPRGTHLCSTTPDRPPPSQASSHHHHHRCHRRRDRKQRSLEKGPSLSADMD
GAPSSAVGPGLPPGEGPTGCRRERERRQERGRSQERRQPSSSSSEKQRFYSCDRFGGREPPKPKPSLSSHPTSPTAGQEPGPHPQGSGSV
NGSPLLSTSGASTPGRGGRRQLPQTPLTPRPSITYKTANSSPIHFAGAQTSLPAFSPGRLSRGLSEHNALLQRDPLSQPLAPGSRIGSDP

--------------------------------------------------------------

>61038_61038_13_NUP214-CACNA1B_NUP214_chr9_134039531_ENST00000451030_CACNA1B_chr9_141006850_ENST00000277549_length(amino acids)=1532AA_BP=1002
LRAAGAEGRKFAVERPGFRGQGRGRQRWLLRHTEGGAMGDEMDAMIPEREMKDFQFRALKKVRIFDSPEELPKERSSLLAVSNKYGLVFA
GGASGLQIFPTKNLLIQNKPGDDPNKIVDKVQGLLVPMKFPIHHLALSCDNLTLSACMMSSEYGSIIAFFDVRTFSNEAKQQKRPFAYHK
LLKDAGGMVIDMKWNPTVPSMVAVCLADGSIAVLQVTETVKVCATLPSTVAVTSVCWSPKGKQLAVGKQNGTVVQYLPTLQEKKVIPCPP
FYESDHPVRVLDVLWIGTYVFAIVYAAADGTLETSPDVVMALLPKKEEKHPEIFVNFMEPCYGSCTERQHHYYLSYIEEWDLVLAASAAS
TEVSILARQSDQINWESWLLEDSSRAELPVTDKSDDSLPMGVVVDYTNQVEITISDEKTLPPAPVLMLLSTDGVLCPFYMINQNPGVKSL
IKTPERLSLEGERQPKSPGSTPTTPTSSQAPQKLDASAAAAPASLPPSSPAAPIATFSLLPAGGAPTVFSFGSSSLKSSATVTGEPPSYS
SGSDSSKAAPGPGPSTFSFVPPSKASLAPTPAASPVAPSAASFSFGSSGFKPTLESTPVPSVSAPNIAMKPSFPPSTSAVKVNLSEKFTA
AATSTPVSSSQSAPPMSPFSSASKPAASGPLSHPTPLSAPPSSVPLKSSVLPSPSAGRSAQGSSSPVPSMVQKSPRITPPAAKPGSPQAK
SLQPAVAEKQGHQWKDSDPVMAGIGEEIAHFQKELEELKARTSKACFQVGTSEEMKMLRTESDDLHTFLLEIKETTESLHGDISSLKTTL
LEGFAGVEEAREQNERNRDSGYLHLLYKRPLDPKSEAQLQEIRRLHQYVKFAVQDVNDVLDLEWDQHLEQKKKQRHLLVPERETLFNTLA
NNREIINQQRKRLNHLVDSLQQLRLYKQTSLWSLSSAVPSQSSIHSFDSDLESLCNALLKTTIESHTKSLPKVPAKLSPMKQAQLRNFLA
KRKTPPVRSTAPAGTKQHQCDAELRKEISVVWANLPQKTLDLLVPPHKPDEMTVGKVYAALMIFDFYKQNKTTRDQMQQAPGGLSQMGPV
SLFHPLKATLEQTQPAVLRGARVFLRQKSSTSLSNGGAIQNQESGIKESVSWGTQRTQDAPHEARPPLERGHSTEIPVGRSGALAVDVQM
QSITRRGPDGEPQPGLESQGRAASMPRLAAETQPVTDASPMKRSISTLAQRPRGTHLCSTTPDRPPPSQASSHHHHHRCHRRRDRKQRSL
EKGPSLSADMDGAPSSAVGPGLPPGEGPTGCRRERERRQERGRSQERRQPSSSSSEKQRFYSCDRFGGREPPKPKPSLSSHPTSPTAGQE
PGPHPQGSGSVNGSPLLSTSGASTPGRGGRRQLPQTPLTPRPSITYKTANSSPIHFAGAQTSLPAFSPGRLSRGLSEHNALLQRDPLSQP
LAPGSRIGSDPYLGQRLDSEASVHALPEDTLTFEEAVATNSGRSSRTSYVSSLTSQSHPLRRVPNGYHCTLGLSSGGRARHSYHHPDQDH

--------------------------------------------------------------

>61038_61038_14_NUP214-CACNA1B_NUP214_chr9_134039531_ENST00000451030_CACNA1B_chr9_141006850_ENST00000277551_length(amino acids)=1430AA_BP=1002
LRAAGAEGRKFAVERPGFRGQGRGRQRWLLRHTEGGAMGDEMDAMIPEREMKDFQFRALKKVRIFDSPEELPKERSSLLAVSNKYGLVFA
GGASGLQIFPTKNLLIQNKPGDDPNKIVDKVQGLLVPMKFPIHHLALSCDNLTLSACMMSSEYGSIIAFFDVRTFSNEAKQQKRPFAYHK
LLKDAGGMVIDMKWNPTVPSMVAVCLADGSIAVLQVTETVKVCATLPSTVAVTSVCWSPKGKQLAVGKQNGTVVQYLPTLQEKKVIPCPP
FYESDHPVRVLDVLWIGTYVFAIVYAAADGTLETSPDVVMALLPKKEEKHPEIFVNFMEPCYGSCTERQHHYYLSYIEEWDLVLAASAAS
TEVSILARQSDQINWESWLLEDSSRAELPVTDKSDDSLPMGVVVDYTNQVEITISDEKTLPPAPVLMLLSTDGVLCPFYMINQNPGVKSL
IKTPERLSLEGERQPKSPGSTPTTPTSSQAPQKLDASAAAAPASLPPSSPAAPIATFSLLPAGGAPTVFSFGSSSLKSSATVTGEPPSYS
SGSDSSKAAPGPGPSTFSFVPPSKASLAPTPAASPVAPSAASFSFGSSGFKPTLESTPVPSVSAPNIAMKPSFPPSTSAVKVNLSEKFTA
AATSTPVSSSQSAPPMSPFSSASKPAASGPLSHPTPLSAPPSSVPLKSSVLPSPSAGRSAQGSSSPVPSMVQKSPRITPPAAKPGSPQAK
SLQPAVAEKQGHQWKDSDPVMAGIGEEIAHFQKELEELKARTSKACFQVGTSEEMKMLRTESDDLHTFLLEIKETTESLHGDISSLKTTL
LEGFAGVEEAREQNERNRDSGYLHLLYKRPLDPKSEAQLQEIRRLHQYVKFAVQDVNDVLDLEWDQHLEQKKKQRHLLVPERETLFNTLA
NNREIINQQRKRLNHLVDSLQQLRLYKQTSLWSLSSAVPSQSSIHSFDSDLESLCNALLKTTIESHTKSLPKVPAKLSPMKQAQLRNFLA
KRKTPPVRSTAPAGTKQHQCDAELRKEISVVWANLPQKTLDLLVPPHKPDEMTVGKVYAALMIFDFYKQNKTTRDQMQQAPGGLSQMGPV
SLFHPLKATLEQTQPAVLRGARVFLRQKSSTSLSNGGAIQNQESGIKESVSWGTQRTQDAPHEARPPLERGHSTEIPVGRSGALAVDVQM
QSITRRGPDGEPQPGLESQGRAASMPRLAAETQPVTDASPMKRSISTLAQRPRGTHLCSTTPDRPPPSQASSHHHHHRCHRRRDRKQRSL
EKGPSLSADMDGAPSSAVGPGLPPGEGPTGCRRERERRQERGRSQERRQPSSSSSEKQRFYSCDRFGGREPPKPKPSLSSHPTSPTAGQE

--------------------------------------------------------------

>61038_61038_15_NUP214-CACNA1B_NUP214_chr9_134039531_ENST00000451030_CACNA1B_chr9_141006850_ENST00000371355_length(amino acids)=1532AA_BP=1002
LRAAGAEGRKFAVERPGFRGQGRGRQRWLLRHTEGGAMGDEMDAMIPEREMKDFQFRALKKVRIFDSPEELPKERSSLLAVSNKYGLVFA
GGASGLQIFPTKNLLIQNKPGDDPNKIVDKVQGLLVPMKFPIHHLALSCDNLTLSACMMSSEYGSIIAFFDVRTFSNEAKQQKRPFAYHK
LLKDAGGMVIDMKWNPTVPSMVAVCLADGSIAVLQVTETVKVCATLPSTVAVTSVCWSPKGKQLAVGKQNGTVVQYLPTLQEKKVIPCPP
FYESDHPVRVLDVLWIGTYVFAIVYAAADGTLETSPDVVMALLPKKEEKHPEIFVNFMEPCYGSCTERQHHYYLSYIEEWDLVLAASAAS
TEVSILARQSDQINWESWLLEDSSRAELPVTDKSDDSLPMGVVVDYTNQVEITISDEKTLPPAPVLMLLSTDGVLCPFYMINQNPGVKSL
IKTPERLSLEGERQPKSPGSTPTTPTSSQAPQKLDASAAAAPASLPPSSPAAPIATFSLLPAGGAPTVFSFGSSSLKSSATVTGEPPSYS
SGSDSSKAAPGPGPSTFSFVPPSKASLAPTPAASPVAPSAASFSFGSSGFKPTLESTPVPSVSAPNIAMKPSFPPSTSAVKVNLSEKFTA
AATSTPVSSSQSAPPMSPFSSASKPAASGPLSHPTPLSAPPSSVPLKSSVLPSPSAGRSAQGSSSPVPSMVQKSPRITPPAAKPGSPQAK
SLQPAVAEKQGHQWKDSDPVMAGIGEEIAHFQKELEELKARTSKACFQVGTSEEMKMLRTESDDLHTFLLEIKETTESLHGDISSLKTTL
LEGFAGVEEAREQNERNRDSGYLHLLYKRPLDPKSEAQLQEIRRLHQYVKFAVQDVNDVLDLEWDQHLEQKKKQRHLLVPERETLFNTLA
NNREIINQQRKRLNHLVDSLQQLRLYKQTSLWSLSSAVPSQSSIHSFDSDLESLCNALLKTTIESHTKSLPKVPAKLSPMKQAQLRNFLA
KRKTPPVRSTAPAGTKQHQCDAELRKEISVVWANLPQKTLDLLVPPHKPDEMTVGKVYAALMIFDFYKQNKTTRDQMQQAPGGLSQMGPV
SLFHPLKATLEQTQPAVLRGARVFLRQKSSTSLSNGGAIQNQESGIKESVSWGTQRTQDAPHEARPPLERGHSTEIPVGRSGALAVDVQM
QSITRRGPDGEPQPGLESQGRAASMPRLAAETQPVTDASPMKRSISTLAQRPRGTHLCSTTPDRPPPSQASSHHHHHRCHRRRDRKQRSL
EKGPSLSADMDGAPSSAVGPGLPPGEGPTGCRRERERRQERGRSQERRQPSSSSSEKQRFYSCDRFGGREPPKPKPSLSSHPTSPTAGQE
PGPHPQGSGSVNGSPLLSTSGASTPGRGGRRQLPQTPLTPRPSITYKTANSSPIHFAGAQTSLPAFSPGRLSRGLSEHNALLQRDPLSQP
LAPGSRIGSDPYLGQRLDSEASVHALPEDTLTFEEAVATNSGRSSRTSYVSSLTSQSHPLRRVPNGYHCTLGLSSGGRARHSYHHPDQDH

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>61038_61038_16_NUP214-CACNA1B_NUP214_chr9_134039531_ENST00000451030_CACNA1B_chr9_141006850_ENST00000371357_length(amino acids)=1532AA_BP=1002
LRAAGAEGRKFAVERPGFRGQGRGRQRWLLRHTEGGAMGDEMDAMIPEREMKDFQFRALKKVRIFDSPEELPKERSSLLAVSNKYGLVFA
GGASGLQIFPTKNLLIQNKPGDDPNKIVDKVQGLLVPMKFPIHHLALSCDNLTLSACMMSSEYGSIIAFFDVRTFSNEAKQQKRPFAYHK
LLKDAGGMVIDMKWNPTVPSMVAVCLADGSIAVLQVTETVKVCATLPSTVAVTSVCWSPKGKQLAVGKQNGTVVQYLPTLQEKKVIPCPP
FYESDHPVRVLDVLWIGTYVFAIVYAAADGTLETSPDVVMALLPKKEEKHPEIFVNFMEPCYGSCTERQHHYYLSYIEEWDLVLAASAAS
TEVSILARQSDQINWESWLLEDSSRAELPVTDKSDDSLPMGVVVDYTNQVEITISDEKTLPPAPVLMLLSTDGVLCPFYMINQNPGVKSL
IKTPERLSLEGERQPKSPGSTPTTPTSSQAPQKLDASAAAAPASLPPSSPAAPIATFSLLPAGGAPTVFSFGSSSLKSSATVTGEPPSYS
SGSDSSKAAPGPGPSTFSFVPPSKASLAPTPAASPVAPSAASFSFGSSGFKPTLESTPVPSVSAPNIAMKPSFPPSTSAVKVNLSEKFTA
AATSTPVSSSQSAPPMSPFSSASKPAASGPLSHPTPLSAPPSSVPLKSSVLPSPSAGRSAQGSSSPVPSMVQKSPRITPPAAKPGSPQAK
SLQPAVAEKQGHQWKDSDPVMAGIGEEIAHFQKELEELKARTSKACFQVGTSEEMKMLRTESDDLHTFLLEIKETTESLHGDISSLKTTL
LEGFAGVEEAREQNERNRDSGYLHLLYKRPLDPKSEAQLQEIRRLHQYVKFAVQDVNDVLDLEWDQHLEQKKKQRHLLVPERETLFNTLA
NNREIINQQRKRLNHLVDSLQQLRLYKQTSLWSLSSAVPSQSSIHSFDSDLESLCNALLKTTIESHTKSLPKVPAKLSPMKQAQLRNFLA
KRKTPPVRSTAPAGTKQHQCDAELRKEISVVWANLPQKTLDLLVPPHKPDEMTVGKVYAALMIFDFYKQNKTTRDQMQQAPGGLSQMGPV
SLFHPLKATLEQTQPAVLRGARVFLRQKSSTSLSNGGAIQNQESGIKESVSWGTQRTQDAPHEARPPLERGHSTEIPVGRSGALAVDVQM
QSITRRGPDGEPQPGLESQGRAASMPRLAAETQPVTDASPMKRSISTLAQRPRGTHLCSTTPDRPPPSQASSHHHHHRCHRRRDRKQRSL
EKGPSLSADMDGAPSSAVGPGLPPGEGPTGCRRERERRQERGRSQERRQPSSSSSEKQRFYSCDRFGGREPPKPKPSLSSHPTSPTAGQE
PGPHPQGSGSVNGSPLLSTSGASTPGRGGRRQLPQTPLTPRPSITYKTANSSPIHFAGAQTSLPAFSPGRLSRGLSEHNALLQRDPLSQP
LAPGSRIGSDPYLGQRLDSEASVHALPEDTLTFEEAVATNSGRSSRTSYVSSLTSQSHPLRRVPNGYHCTLGLSSGGRARHSYHHPDQDH

--------------------------------------------------------------

>61038_61038_17_NUP214-CACNA1B_NUP214_chr9_134039531_ENST00000451030_CACNA1B_chr9_141006850_ENST00000371363_length(amino acids)=1532AA_BP=1002
LRAAGAEGRKFAVERPGFRGQGRGRQRWLLRHTEGGAMGDEMDAMIPEREMKDFQFRALKKVRIFDSPEELPKERSSLLAVSNKYGLVFA
GGASGLQIFPTKNLLIQNKPGDDPNKIVDKVQGLLVPMKFPIHHLALSCDNLTLSACMMSSEYGSIIAFFDVRTFSNEAKQQKRPFAYHK
LLKDAGGMVIDMKWNPTVPSMVAVCLADGSIAVLQVTETVKVCATLPSTVAVTSVCWSPKGKQLAVGKQNGTVVQYLPTLQEKKVIPCPP
FYESDHPVRVLDVLWIGTYVFAIVYAAADGTLETSPDVVMALLPKKEEKHPEIFVNFMEPCYGSCTERQHHYYLSYIEEWDLVLAASAAS
TEVSILARQSDQINWESWLLEDSSRAELPVTDKSDDSLPMGVVVDYTNQVEITISDEKTLPPAPVLMLLSTDGVLCPFYMINQNPGVKSL
IKTPERLSLEGERQPKSPGSTPTTPTSSQAPQKLDASAAAAPASLPPSSPAAPIATFSLLPAGGAPTVFSFGSSSLKSSATVTGEPPSYS
SGSDSSKAAPGPGPSTFSFVPPSKASLAPTPAASPVAPSAASFSFGSSGFKPTLESTPVPSVSAPNIAMKPSFPPSTSAVKVNLSEKFTA
AATSTPVSSSQSAPPMSPFSSASKPAASGPLSHPTPLSAPPSSVPLKSSVLPSPSAGRSAQGSSSPVPSMVQKSPRITPPAAKPGSPQAK
SLQPAVAEKQGHQWKDSDPVMAGIGEEIAHFQKELEELKARTSKACFQVGTSEEMKMLRTESDDLHTFLLEIKETTESLHGDISSLKTTL
LEGFAGVEEAREQNERNRDSGYLHLLYKRPLDPKSEAQLQEIRRLHQYVKFAVQDVNDVLDLEWDQHLEQKKKQRHLLVPERETLFNTLA
NNREIINQQRKRLNHLVDSLQQLRLYKQTSLWSLSSAVPSQSSIHSFDSDLESLCNALLKTTIESHTKSLPKVPAKLSPMKQAQLRNFLA
KRKTPPVRSTAPAGTKQHQCDAELRKEISVVWANLPQKTLDLLVPPHKPDEMTVGKVYAALMIFDFYKQNKTTRDQMQQAPGGLSQMGPV
SLFHPLKATLEQTQPAVLRGARVFLRQKSSTSLSNGGAIQNQESGIKESVSWGTQRTQDAPHEARPPLERGHSTEIPVGRSGALAVDVQM
QSITRRGPDGEPQPGLESQGRAASMPRLAAETQPVTDASPMKRSISTLAQRPRGTHLCSTTPDRPPPSQASSHHHHHRCHRRRDRKQRSL
EKGPSLSADMDGAPSSAVGPGLPPGEGPTGCRRERERRQERGRSQERRQPSSSSSEKQRFYSCDRFGGREPPKPKPSLSSHPTSPTAGQE
PGPHPQGSGSVNGSPLLSTSGASTPGRGGRRQLPQTPLTPRPSITYKTANSSPIHFAGAQTSLPAFSPGRLSRGLSEHNALLQRDPLSQP
LAPGSRIGSDPYLGQRLDSEASVHALPEDTLTFEEAVATNSGRSSRTSYVSSLTSQSHPLRRVPNGYHCTLGLSSGGRARHSYHHPDQDH

--------------------------------------------------------------

>61038_61038_18_NUP214-CACNA1B_NUP214_chr9_134039531_ENST00000451030_CACNA1B_chr9_141006850_ENST00000371372_length(amino acids)=1532AA_BP=1002
LRAAGAEGRKFAVERPGFRGQGRGRQRWLLRHTEGGAMGDEMDAMIPEREMKDFQFRALKKVRIFDSPEELPKERSSLLAVSNKYGLVFA
GGASGLQIFPTKNLLIQNKPGDDPNKIVDKVQGLLVPMKFPIHHLALSCDNLTLSACMMSSEYGSIIAFFDVRTFSNEAKQQKRPFAYHK
LLKDAGGMVIDMKWNPTVPSMVAVCLADGSIAVLQVTETVKVCATLPSTVAVTSVCWSPKGKQLAVGKQNGTVVQYLPTLQEKKVIPCPP
FYESDHPVRVLDVLWIGTYVFAIVYAAADGTLETSPDVVMALLPKKEEKHPEIFVNFMEPCYGSCTERQHHYYLSYIEEWDLVLAASAAS
TEVSILARQSDQINWESWLLEDSSRAELPVTDKSDDSLPMGVVVDYTNQVEITISDEKTLPPAPVLMLLSTDGVLCPFYMINQNPGVKSL
IKTPERLSLEGERQPKSPGSTPTTPTSSQAPQKLDASAAAAPASLPPSSPAAPIATFSLLPAGGAPTVFSFGSSSLKSSATVTGEPPSYS
SGSDSSKAAPGPGPSTFSFVPPSKASLAPTPAASPVAPSAASFSFGSSGFKPTLESTPVPSVSAPNIAMKPSFPPSTSAVKVNLSEKFTA
AATSTPVSSSQSAPPMSPFSSASKPAASGPLSHPTPLSAPPSSVPLKSSVLPSPSAGRSAQGSSSPVPSMVQKSPRITPPAAKPGSPQAK
SLQPAVAEKQGHQWKDSDPVMAGIGEEIAHFQKELEELKARTSKACFQVGTSEEMKMLRTESDDLHTFLLEIKETTESLHGDISSLKTTL
LEGFAGVEEAREQNERNRDSGYLHLLYKRPLDPKSEAQLQEIRRLHQYVKFAVQDVNDVLDLEWDQHLEQKKKQRHLLVPERETLFNTLA
NNREIINQQRKRLNHLVDSLQQLRLYKQTSLWSLSSAVPSQSSIHSFDSDLESLCNALLKTTIESHTKSLPKVPAKLSPMKQAQLRNFLA
KRKTPPVRSTAPAGTKQHQCDAELRKEISVVWANLPQKTLDLLVPPHKPDEMTVGKVYAALMIFDFYKQNKTTRDQMQQAPGGLSQMGPV
SLFHPLKATLEQTQPAVLRGARVFLRQKSSTSLSNGGAIQNQESGIKESVSWGTQRTQDAPHEARPPLERGHSTEIPVGRSGALAVDVQM
QSITRRGPDGEPQPGLESQGRAASMPRLAAETQPVTDASPMKRSISTLAQRPRGTHLCSTTPDRPPPSQASSHHHHHRCHRRRDRKQRSL
EKGPSLSADMDGAPSSAVGPGLPPGEGPTGCRRERERRQERGRSQERRQPSSSSSEKQRFYSCDRFGGREPPKPKPSLSSHPTSPTAGQE
PGPHPQGSGSVNGSPLLSTSGASTPGRGGRRQLPQTPLTPRPSITYKTANSSPIHFAGAQTSLPAFSPGRLSRGLSEHNALLQRDPLSQP
LAPGSRIGSDPYLGQRLDSEASVHALPEDTLTFEEAVATNSGRSSRTSYVSSLTSQSHPLRRVPNGYHCTLGLSSGGRARHSYHHPDQDH

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr9:134039531/chr9:141006850)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
NUP214

P35658

CACNA1B

Q00975

FUNCTION: Part of the nuclear pore complex (PubMed:9049309). Has a critical role in nucleocytoplasmic transport (PubMed:31178128). May serve as a docking site in the receptor-mediated import of substrates across the nuclear pore complex (PubMed:31178128, PubMed:8108440). {ECO:0000269|PubMed:31178128, ECO:0000269|PubMed:9049309, ECO:0000303|PubMed:8108440}.; FUNCTION: (Microbial infection) Required for capsid disassembly of the human adenovirus 5 (HadV-5) leading to release of the viral genome to the nucleus (in vitro). {ECO:0000269|PubMed:25410864}.FUNCTION: Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1B gives rise to N-type calcium currents. N-type calcium channels belong to the 'high-voltage activated' (HVA) group and are specifically blocked by omega-conotoxin-GVIA (AC P01522) (AC P01522) (By similarity). They are however insensitive to dihydropyridines (DHP). Calcium channels containing alpha-1B subunit may play a role in directed migration of immature neurons. {ECO:0000250|UniProtKB:Q02294}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneNUP214chr9:134039531chr9:141006850ENST00000359428+213641_404964.33333333333342091.0RegionNote=Seven-bladed beta propeller
HgeneNUP214chr9:134039531chr9:141006850ENST00000359428+2136450_586964.33333333333342091.0Region(Microbial infection) Binds human adenovirus 5 (HAdV-5) protein L3 (hexon)
HgeneNUP214chr9:134039531chr9:141006850ENST00000359428+2136740_768964.33333333333342091.0RegionNote=Leucine-zipper 1
HgeneNUP214chr9:134039531chr9:141006850ENST00000359428+2136861_882964.33333333333342091.0RegionNote=Leucine-zipper 2
HgeneNUP214chr9:134039531chr9:141006850ENST00000411637+213641_404954.33333333333342081.0RegionNote=Seven-bladed beta propeller
HgeneNUP214chr9:134039531chr9:141006850ENST00000411637+2136450_586954.33333333333342081.0Region(Microbial infection) Binds human adenovirus 5 (HAdV-5) protein L3 (hexon)
HgeneNUP214chr9:134039531chr9:141006850ENST00000411637+2136740_768954.33333333333342081.0RegionNote=Leucine-zipper 1
HgeneNUP214chr9:134039531chr9:141006850ENST00000411637+2136861_882954.33333333333342081.0RegionNote=Leucine-zipper 2
HgeneNUP214chr9:134039531chr9:141006850ENST00000451030+213641_404965.33333333333342092.0RegionNote=Seven-bladed beta propeller
HgeneNUP214chr9:134039531chr9:141006850ENST00000451030+2136450_586965.33333333333342092.0Region(Microbial infection) Binds human adenovirus 5 (HAdV-5) protein L3 (hexon)
HgeneNUP214chr9:134039531chr9:141006850ENST00000451030+2136740_768965.33333333333342092.0RegionNote=Leucine-zipper 1
HgeneNUP214chr9:134039531chr9:141006850ENST00000451030+2136861_882965.33333333333342092.0RegionNote=Leucine-zipper 2
HgeneNUP214chr9:134039531chr9:141006850ENST00000359428+2136151_193964.33333333333342091.0RepeatNote=Blade 3
HgeneNUP214chr9:134039531chr9:141006850ENST00000359428+2136194_239964.33333333333342091.0RepeatNote=Blade 4
HgeneNUP214chr9:134039531chr9:141006850ENST00000359428+2136240_303964.33333333333342091.0RepeatNote=Blade 5
HgeneNUP214chr9:134039531chr9:141006850ENST00000359428+2136304_359964.33333333333342091.0RepeatNote=Blade 6
HgeneNUP214chr9:134039531chr9:141006850ENST00000359428+2136360_404964.33333333333342091.0RepeatNote=Blade 7
HgeneNUP214chr9:134039531chr9:141006850ENST00000359428+213641_93964.33333333333342091.0RepeatNote=Blade 1
HgeneNUP214chr9:134039531chr9:141006850ENST00000359428+2136484_485964.33333333333342091.0Repeat1
HgeneNUP214chr9:134039531chr9:141006850ENST00000359428+2136548_549964.33333333333342091.0Repeat2
HgeneNUP214chr9:134039531chr9:141006850ENST00000359428+213694_150964.33333333333342091.0RepeatNote=Blade 2
HgeneNUP214chr9:134039531chr9:141006850ENST00000411637+2136151_193954.33333333333342081.0RepeatNote=Blade 3
HgeneNUP214chr9:134039531chr9:141006850ENST00000411637+2136194_239954.33333333333342081.0RepeatNote=Blade 4
HgeneNUP214chr9:134039531chr9:141006850ENST00000411637+2136240_303954.33333333333342081.0RepeatNote=Blade 5
HgeneNUP214chr9:134039531chr9:141006850ENST00000411637+2136304_359954.33333333333342081.0RepeatNote=Blade 6
HgeneNUP214chr9:134039531chr9:141006850ENST00000411637+2136360_404954.33333333333342081.0RepeatNote=Blade 7
HgeneNUP214chr9:134039531chr9:141006850ENST00000411637+213641_93954.33333333333342081.0RepeatNote=Blade 1
HgeneNUP214chr9:134039531chr9:141006850ENST00000411637+2136484_485954.33333333333342081.0Repeat1
HgeneNUP214chr9:134039531chr9:141006850ENST00000411637+2136548_549954.33333333333342081.0Repeat2
HgeneNUP214chr9:134039531chr9:141006850ENST00000411637+213694_150954.33333333333342081.0RepeatNote=Blade 2
HgeneNUP214chr9:134039531chr9:141006850ENST00000451030+2136151_193965.33333333333342092.0RepeatNote=Blade 3
HgeneNUP214chr9:134039531chr9:141006850ENST00000451030+2136194_239965.33333333333342092.0RepeatNote=Blade 4
HgeneNUP214chr9:134039531chr9:141006850ENST00000451030+2136240_303965.33333333333342092.0RepeatNote=Blade 5
HgeneNUP214chr9:134039531chr9:141006850ENST00000451030+2136304_359965.33333333333342092.0RepeatNote=Blade 6
HgeneNUP214chr9:134039531chr9:141006850ENST00000451030+2136360_404965.33333333333342092.0RepeatNote=Blade 7
HgeneNUP214chr9:134039531chr9:141006850ENST00000451030+213641_93965.33333333333342092.0RepeatNote=Blade 1
HgeneNUP214chr9:134039531chr9:141006850ENST00000451030+2136484_485965.33333333333342092.0Repeat1
HgeneNUP214chr9:134039531chr9:141006850ENST00000451030+2136548_549965.33333333333342092.0Repeat2
HgeneNUP214chr9:134039531chr9:141006850ENST00000451030+213694_150965.33333333333342092.0RepeatNote=Blade 2
TgeneCACNA1Bchr9:134039531chr9:141006850ENST0000037137238472050_20541809.33333333333332340.0Compositional biasNote=Poly-His
TgeneCACNA1Bchr9:134039531chr9:141006850ENST0000037137238472118_21221809.33333333333332340.0Compositional biasNote=Poly-Ser

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneNUP214chr9:134039531chr9:141006850ENST00000359428+2136680_1209964.33333333333342091.0Coiled coilOntology_term=ECO:0000269
HgeneNUP214chr9:134039531chr9:141006850ENST00000411637+2136680_1209954.33333333333342081.0Coiled coilOntology_term=ECO:0000269
HgeneNUP214chr9:134039531chr9:141006850ENST00000451030+2136680_1209965.33333333333342092.0Coiled coilOntology_term=ECO:0000269
HgeneNUP214chr9:134039531chr9:141006850ENST00000359428+21361213_2090964.33333333333342091.0Compositional biasNote=Pro/Ser/Thr-rich
HgeneNUP214chr9:134039531chr9:141006850ENST00000411637+21361213_2090954.33333333333342081.0Compositional biasNote=Pro/Ser/Thr-rich
HgeneNUP214chr9:134039531chr9:141006850ENST00000451030+21361213_2090965.33333333333342092.0Compositional biasNote=Pro/Ser/Thr-rich
HgeneNUP214chr9:134039531chr9:141006850ENST00000359428+21361409_2084964.33333333333342091.0RegionNote=18 X 4 AA approximate repeats
HgeneNUP214chr9:134039531chr9:141006850ENST00000359428+21361427_2085964.33333333333342091.0RegionNote=11 X 3 AA approximate repeats
HgeneNUP214chr9:134039531chr9:141006850ENST00000359428+2136236_1418964.33333333333342091.0Region44 X 2 AA repeats of F-G
HgeneNUP214chr9:134039531chr9:141006850ENST00000359428+2136481_2076964.33333333333342091.0RegionNote=11 X 5 AA approximate repeats
HgeneNUP214chr9:134039531chr9:141006850ENST00000411637+21361409_2084954.33333333333342081.0RegionNote=18 X 4 AA approximate repeats
HgeneNUP214chr9:134039531chr9:141006850ENST00000411637+21361427_2085954.33333333333342081.0RegionNote=11 X 3 AA approximate repeats
HgeneNUP214chr9:134039531chr9:141006850ENST00000411637+2136236_1418954.33333333333342081.0Region44 X 2 AA repeats of F-G
HgeneNUP214chr9:134039531chr9:141006850ENST00000411637+2136481_2076954.33333333333342081.0RegionNote=11 X 5 AA approximate repeats
HgeneNUP214chr9:134039531chr9:141006850ENST00000451030+21361409_2084965.33333333333342092.0RegionNote=18 X 4 AA approximate repeats
HgeneNUP214chr9:134039531chr9:141006850ENST00000451030+21361427_2085965.33333333333342092.0RegionNote=11 X 3 AA approximate repeats
HgeneNUP214chr9:134039531chr9:141006850ENST00000451030+2136236_1418965.33333333333342092.0Region44 X 2 AA repeats of F-G
HgeneNUP214chr9:134039531chr9:141006850ENST00000451030+2136481_2076965.33333333333342092.0RegionNote=11 X 5 AA approximate repeats
HgeneNUP214chr9:134039531chr9:141006850ENST00000359428+21361225_1226964.33333333333342091.0Repeat3
HgeneNUP214chr9:134039531chr9:141006850ENST00000359428+21361411_1412964.33333333333342091.0Repeat4
HgeneNUP214chr9:134039531chr9:141006850ENST00000359428+21361427_1428964.33333333333342091.0Repeat5
HgeneNUP214chr9:134039531chr9:141006850ENST00000359428+21361441_1442964.33333333333342091.0Repeat6
HgeneNUP214chr9:134039531chr9:141006850ENST00000359428+21361473_1474964.33333333333342091.0Repeat7
HgeneNUP214chr9:134039531chr9:141006850ENST00000359428+21361635_1636964.33333333333342091.0Repeat8
HgeneNUP214chr9:134039531chr9:141006850ENST00000359428+21361674_1675964.33333333333342091.0Repeat9
HgeneNUP214chr9:134039531chr9:141006850ENST00000359428+21361686_1687964.33333333333342091.0Repeat10
HgeneNUP214chr9:134039531chr9:141006850ENST00000359428+21361713_1714964.33333333333342091.0Repeat11
HgeneNUP214chr9:134039531chr9:141006850ENST00000359428+21361721_1722964.33333333333342091.0Repeat12
HgeneNUP214chr9:134039531chr9:141006850ENST00000359428+21361726_1727964.33333333333342091.0Repeat13
HgeneNUP214chr9:134039531chr9:141006850ENST00000359428+21361732_1733964.33333333333342091.0Repeat14
HgeneNUP214chr9:134039531chr9:141006850ENST00000359428+21361756_1757964.33333333333342091.0Repeat15
HgeneNUP214chr9:134039531chr9:141006850ENST00000359428+21361772_1773964.33333333333342091.0Repeat16
HgeneNUP214chr9:134039531chr9:141006850ENST00000359428+21361786_1787964.33333333333342091.0Repeat17
HgeneNUP214chr9:134039531chr9:141006850ENST00000359428+21361798_1799964.33333333333342091.0Repeat18
HgeneNUP214chr9:134039531chr9:141006850ENST00000359428+21361806_1807964.33333333333342091.0Repeat19
HgeneNUP214chr9:134039531chr9:141006850ENST00000359428+21361812_1813964.33333333333342091.0Repeat20
HgeneNUP214chr9:134039531chr9:141006850ENST00000359428+21361819_1820964.33333333333342091.0Repeat21
HgeneNUP214chr9:134039531chr9:141006850ENST00000359428+21361842_1843964.33333333333342091.0Repeat22
HgeneNUP214chr9:134039531chr9:141006850ENST00000359428+21361851_1852964.33333333333342091.0Repeat23
HgeneNUP214chr9:134039531chr9:141006850ENST00000359428+21361862_1863964.33333333333342091.0Repeat24
HgeneNUP214chr9:134039531chr9:141006850ENST00000359428+21361874_1875964.33333333333342091.0Repeat25
HgeneNUP214chr9:134039531chr9:141006850ENST00000359428+21361910_1911964.33333333333342091.0Repeat26
HgeneNUP214chr9:134039531chr9:141006850ENST00000359428+21361922_1923964.33333333333342091.0Repeat27
HgeneNUP214chr9:134039531chr9:141006850ENST00000359428+21361930_1931964.33333333333342091.0Repeat28
HgeneNUP214chr9:134039531chr9:141006850ENST00000359428+21361938_1939964.33333333333342091.0Repeat29
HgeneNUP214chr9:134039531chr9:141006850ENST00000359428+21361959_1960964.33333333333342091.0Repeat30
HgeneNUP214chr9:134039531chr9:141006850ENST00000359428+21361970_1971964.33333333333342091.0Repeat31
HgeneNUP214chr9:134039531chr9:141006850ENST00000359428+21361976_1977964.33333333333342091.0Repeat32
HgeneNUP214chr9:134039531chr9:141006850ENST00000359428+21361982_1983964.33333333333342091.0Repeat33
HgeneNUP214chr9:134039531chr9:141006850ENST00000359428+21361988_1989964.33333333333342091.0Repeat34
HgeneNUP214chr9:134039531chr9:141006850ENST00000359428+21361994_1995964.33333333333342091.0Repeat35
HgeneNUP214chr9:134039531chr9:141006850ENST00000359428+21362012_2013964.33333333333342091.0Repeat36
HgeneNUP214chr9:134039531chr9:141006850ENST00000359428+21362024_2025964.33333333333342091.0Repeat37
HgeneNUP214chr9:134039531chr9:141006850ENST00000359428+21362026_2027964.33333333333342091.0Repeat38
HgeneNUP214chr9:134039531chr9:141006850ENST00000359428+21362035_2036964.33333333333342091.0Repeat39
HgeneNUP214chr9:134039531chr9:141006850ENST00000359428+21362046_2047964.33333333333342091.0Repeat40
HgeneNUP214chr9:134039531chr9:141006850ENST00000359428+21362056_2057964.33333333333342091.0Repeat41
HgeneNUP214chr9:134039531chr9:141006850ENST00000359428+21362066_2067964.33333333333342091.0Repeat42
HgeneNUP214chr9:134039531chr9:141006850ENST00000359428+21362075_2076964.33333333333342091.0Repeat43
HgeneNUP214chr9:134039531chr9:141006850ENST00000359428+21362085_2086964.33333333333342091.0Repeat44
HgeneNUP214chr9:134039531chr9:141006850ENST00000411637+21361225_1226954.33333333333342081.0Repeat3
HgeneNUP214chr9:134039531chr9:141006850ENST00000411637+21361411_1412954.33333333333342081.0Repeat4
HgeneNUP214chr9:134039531chr9:141006850ENST00000411637+21361427_1428954.33333333333342081.0Repeat5
HgeneNUP214chr9:134039531chr9:141006850ENST00000411637+21361441_1442954.33333333333342081.0Repeat6
HgeneNUP214chr9:134039531chr9:141006850ENST00000411637+21361473_1474954.33333333333342081.0Repeat7
HgeneNUP214chr9:134039531chr9:141006850ENST00000411637+21361635_1636954.33333333333342081.0Repeat8
HgeneNUP214chr9:134039531chr9:141006850ENST00000411637+21361674_1675954.33333333333342081.0Repeat9
HgeneNUP214chr9:134039531chr9:141006850ENST00000411637+21361686_1687954.33333333333342081.0Repeat10
HgeneNUP214chr9:134039531chr9:141006850ENST00000411637+21361713_1714954.33333333333342081.0Repeat11
HgeneNUP214chr9:134039531chr9:141006850ENST00000411637+21361721_1722954.33333333333342081.0Repeat12
HgeneNUP214chr9:134039531chr9:141006850ENST00000411637+21361726_1727954.33333333333342081.0Repeat13
HgeneNUP214chr9:134039531chr9:141006850ENST00000411637+21361732_1733954.33333333333342081.0Repeat14
HgeneNUP214chr9:134039531chr9:141006850ENST00000411637+21361756_1757954.33333333333342081.0Repeat15
HgeneNUP214chr9:134039531chr9:141006850ENST00000411637+21361772_1773954.33333333333342081.0Repeat16
HgeneNUP214chr9:134039531chr9:141006850ENST00000411637+21361786_1787954.33333333333342081.0Repeat17
HgeneNUP214chr9:134039531chr9:141006850ENST00000411637+21361798_1799954.33333333333342081.0Repeat18
HgeneNUP214chr9:134039531chr9:141006850ENST00000411637+21361806_1807954.33333333333342081.0Repeat19
HgeneNUP214chr9:134039531chr9:141006850ENST00000411637+21361812_1813954.33333333333342081.0Repeat20
HgeneNUP214chr9:134039531chr9:141006850ENST00000411637+21361819_1820954.33333333333342081.0Repeat21
HgeneNUP214chr9:134039531chr9:141006850ENST00000411637+21361842_1843954.33333333333342081.0Repeat22
HgeneNUP214chr9:134039531chr9:141006850ENST00000411637+21361851_1852954.33333333333342081.0Repeat23
HgeneNUP214chr9:134039531chr9:141006850ENST00000411637+21361862_1863954.33333333333342081.0Repeat24
HgeneNUP214chr9:134039531chr9:141006850ENST00000411637+21361874_1875954.33333333333342081.0Repeat25
HgeneNUP214chr9:134039531chr9:141006850ENST00000411637+21361910_1911954.33333333333342081.0Repeat26
HgeneNUP214chr9:134039531chr9:141006850ENST00000411637+21361922_1923954.33333333333342081.0Repeat27
HgeneNUP214chr9:134039531chr9:141006850ENST00000411637+21361930_1931954.33333333333342081.0Repeat28
HgeneNUP214chr9:134039531chr9:141006850ENST00000411637+21361938_1939954.33333333333342081.0Repeat29
HgeneNUP214chr9:134039531chr9:141006850ENST00000411637+21361959_1960954.33333333333342081.0Repeat30
HgeneNUP214chr9:134039531chr9:141006850ENST00000411637+21361970_1971954.33333333333342081.0Repeat31
HgeneNUP214chr9:134039531chr9:141006850ENST00000411637+21361976_1977954.33333333333342081.0Repeat32
HgeneNUP214chr9:134039531chr9:141006850ENST00000411637+21361982_1983954.33333333333342081.0Repeat33
HgeneNUP214chr9:134039531chr9:141006850ENST00000411637+21361988_1989954.33333333333342081.0Repeat34
HgeneNUP214chr9:134039531chr9:141006850ENST00000411637+21361994_1995954.33333333333342081.0Repeat35
HgeneNUP214chr9:134039531chr9:141006850ENST00000411637+21362012_2013954.33333333333342081.0Repeat36
HgeneNUP214chr9:134039531chr9:141006850ENST00000411637+21362024_2025954.33333333333342081.0Repeat37
HgeneNUP214chr9:134039531chr9:141006850ENST00000411637+21362026_2027954.33333333333342081.0Repeat38
HgeneNUP214chr9:134039531chr9:141006850ENST00000411637+21362035_2036954.33333333333342081.0Repeat39
HgeneNUP214chr9:134039531chr9:141006850ENST00000411637+21362046_2047954.33333333333342081.0Repeat40
HgeneNUP214chr9:134039531chr9:141006850ENST00000411637+21362056_2057954.33333333333342081.0Repeat41
HgeneNUP214chr9:134039531chr9:141006850ENST00000411637+21362066_2067954.33333333333342081.0Repeat42
HgeneNUP214chr9:134039531chr9:141006850ENST00000411637+21362075_2076954.33333333333342081.0Repeat43
HgeneNUP214chr9:134039531chr9:141006850ENST00000411637+21362085_2086954.33333333333342081.0Repeat44
HgeneNUP214chr9:134039531chr9:141006850ENST00000451030+21361225_1226965.33333333333342092.0Repeat3
HgeneNUP214chr9:134039531chr9:141006850ENST00000451030+21361411_1412965.33333333333342092.0Repeat4
HgeneNUP214chr9:134039531chr9:141006850ENST00000451030+21361427_1428965.33333333333342092.0Repeat5
HgeneNUP214chr9:134039531chr9:141006850ENST00000451030+21361441_1442965.33333333333342092.0Repeat6
HgeneNUP214chr9:134039531chr9:141006850ENST00000451030+21361473_1474965.33333333333342092.0Repeat7
HgeneNUP214chr9:134039531chr9:141006850ENST00000451030+21361635_1636965.33333333333342092.0Repeat8
HgeneNUP214chr9:134039531chr9:141006850ENST00000451030+21361674_1675965.33333333333342092.0Repeat9
HgeneNUP214chr9:134039531chr9:141006850ENST00000451030+21361686_1687965.33333333333342092.0Repeat10
HgeneNUP214chr9:134039531chr9:141006850ENST00000451030+21361713_1714965.33333333333342092.0Repeat11
HgeneNUP214chr9:134039531chr9:141006850ENST00000451030+21361721_1722965.33333333333342092.0Repeat12
HgeneNUP214chr9:134039531chr9:141006850ENST00000451030+21361726_1727965.33333333333342092.0Repeat13
HgeneNUP214chr9:134039531chr9:141006850ENST00000451030+21361732_1733965.33333333333342092.0Repeat14
HgeneNUP214chr9:134039531chr9:141006850ENST00000451030+21361756_1757965.33333333333342092.0Repeat15
HgeneNUP214chr9:134039531chr9:141006850ENST00000451030+21361772_1773965.33333333333342092.0Repeat16
HgeneNUP214chr9:134039531chr9:141006850ENST00000451030+21361786_1787965.33333333333342092.0Repeat17
HgeneNUP214chr9:134039531chr9:141006850ENST00000451030+21361798_1799965.33333333333342092.0Repeat18
HgeneNUP214chr9:134039531chr9:141006850ENST00000451030+21361806_1807965.33333333333342092.0Repeat19
HgeneNUP214chr9:134039531chr9:141006850ENST00000451030+21361812_1813965.33333333333342092.0Repeat20
HgeneNUP214chr9:134039531chr9:141006850ENST00000451030+21361819_1820965.33333333333342092.0Repeat21
HgeneNUP214chr9:134039531chr9:141006850ENST00000451030+21361842_1843965.33333333333342092.0Repeat22
HgeneNUP214chr9:134039531chr9:141006850ENST00000451030+21361851_1852965.33333333333342092.0Repeat23
HgeneNUP214chr9:134039531chr9:141006850ENST00000451030+21361862_1863965.33333333333342092.0Repeat24
HgeneNUP214chr9:134039531chr9:141006850ENST00000451030+21361874_1875965.33333333333342092.0Repeat25
HgeneNUP214chr9:134039531chr9:141006850ENST00000451030+21361910_1911965.33333333333342092.0Repeat26
HgeneNUP214chr9:134039531chr9:141006850ENST00000451030+21361922_1923965.33333333333342092.0Repeat27
HgeneNUP214chr9:134039531chr9:141006850ENST00000451030+21361930_1931965.33333333333342092.0Repeat28
HgeneNUP214chr9:134039531chr9:141006850ENST00000451030+21361938_1939965.33333333333342092.0Repeat29
HgeneNUP214chr9:134039531chr9:141006850ENST00000451030+21361959_1960965.33333333333342092.0Repeat30
HgeneNUP214chr9:134039531chr9:141006850ENST00000451030+21361970_1971965.33333333333342092.0Repeat31
HgeneNUP214chr9:134039531chr9:141006850ENST00000451030+21361976_1977965.33333333333342092.0Repeat32
HgeneNUP214chr9:134039531chr9:141006850ENST00000451030+21361982_1983965.33333333333342092.0Repeat33
HgeneNUP214chr9:134039531chr9:141006850ENST00000451030+21361988_1989965.33333333333342092.0Repeat34
HgeneNUP214chr9:134039531chr9:141006850ENST00000451030+21361994_1995965.33333333333342092.0Repeat35
HgeneNUP214chr9:134039531chr9:141006850ENST00000451030+21362012_2013965.33333333333342092.0Repeat36
HgeneNUP214chr9:134039531chr9:141006850ENST00000451030+21362024_2025965.33333333333342092.0Repeat37
HgeneNUP214chr9:134039531chr9:141006850ENST00000451030+21362026_2027965.33333333333342092.0Repeat38
HgeneNUP214chr9:134039531chr9:141006850ENST00000451030+21362035_2036965.33333333333342092.0Repeat39
HgeneNUP214chr9:134039531chr9:141006850ENST00000451030+21362046_2047965.33333333333342092.0Repeat40
HgeneNUP214chr9:134039531chr9:141006850ENST00000451030+21362056_2057965.33333333333342092.0Repeat41
HgeneNUP214chr9:134039531chr9:141006850ENST00000451030+21362066_2067965.33333333333342092.0Repeat42
HgeneNUP214chr9:134039531chr9:141006850ENST00000451030+21362075_2076965.33333333333342092.0Repeat43
HgeneNUP214chr9:134039531chr9:141006850ENST00000451030+21362085_2086965.33333333333342092.0Repeat44
TgeneCACNA1Bchr9:134039531chr9:141006850ENST0000037137238471737_17481809.33333333333332340.0Calcium bindingOntology_term=ECO:0000255
TgeneCACNA1Bchr9:134039531chr9:141006850ENST0000037137238471724_17591809.33333333333332340.0DomainEF-hand
TgeneCACNA1Bchr9:134039531chr9:141006850ENST000003713723847451_4581809.33333333333332340.0Nucleotide bindingATP
TgeneCACNA1Bchr9:134039531chr9:141006850ENST000003713723847379_3961809.33333333333332340.0RegionBinding to the beta subunit
TgeneCACNA1Bchr9:134039531chr9:141006850ENST0000037137238471137_14191809.33333333333332340.0RepeatNote=III
TgeneCACNA1Bchr9:134039531chr9:141006850ENST0000037137238471456_17111809.33333333333332340.0RepeatNote=IV
TgeneCACNA1Bchr9:134039531chr9:141006850ENST000003713723847468_7121809.33333333333332340.0RepeatNote=II
TgeneCACNA1Bchr9:134039531chr9:141006850ENST00000371372384782_3591809.33333333333332340.0RepeatNote=I
TgeneCACNA1Bchr9:134039531chr9:141006850ENST000003713723847115_1321809.33333333333332340.0Topological domainExtracellular
TgeneCACNA1Bchr9:134039531chr9:141006850ENST0000037137238471170_11851809.33333333333332340.0Topological domainExtracellular
TgeneCACNA1Bchr9:134039531chr9:141006850ENST0000037137238471206_12171809.33333333333332340.0Topological domainCytoplasmic
TgeneCACNA1Bchr9:134039531chr9:141006850ENST0000037137238471237_12461809.33333333333332340.0Topological domainExtracellular
TgeneCACNA1Bchr9:134039531chr9:141006850ENST0000037137238471266_12841809.33333333333332340.0Topological domainCytoplasmic
TgeneCACNA1Bchr9:134039531chr9:141006850ENST0000037137238471305_13911809.33333333333332340.0Topological domainExtracellular
TgeneCACNA1Bchr9:134039531chr9:141006850ENST0000037137238471417_14711809.33333333333332340.0Topological domainCytoplasmic
TgeneCACNA1Bchr9:134039531chr9:141006850ENST0000037137238471491_15051809.33333333333332340.0Topological domainExtracellular
TgeneCACNA1Bchr9:134039531chr9:141006850ENST0000037137238471526_15331809.33333333333332340.0Topological domainCytoplasmic
TgeneCACNA1Bchr9:134039531chr9:141006850ENST000003713723847153_1631809.33333333333332340.0Topological domainCytoplasmic
TgeneCACNA1Bchr9:134039531chr9:141006850ENST0000037137238471553_15631809.33333333333332340.0Topological domainExtracellular
TgeneCACNA1Bchr9:134039531chr9:141006850ENST0000037137238471583_16011809.33333333333332340.0Topological domainCytoplasmic
TgeneCACNA1Bchr9:134039531chr9:141006850ENST0000037137238471622_16831809.33333333333332340.0Topological domainExtracellular
TgeneCACNA1Bchr9:134039531chr9:141006850ENST0000037137238471709_23391809.33333333333332340.0Topological domainCytoplasmic
TgeneCACNA1Bchr9:134039531chr9:141006850ENST000003713723847184_1871809.33333333333332340.0Topological domainExtracellular
TgeneCACNA1Bchr9:134039531chr9:141006850ENST0000037137238471_951809.33333333333332340.0Topological domainCytoplasmic
TgeneCACNA1Bchr9:134039531chr9:141006850ENST000003713723847207_2251809.33333333333332340.0Topological domainCytoplasmic
TgeneCACNA1Bchr9:134039531chr9:141006850ENST000003713723847246_3311809.33333333333332340.0Topological domainExtracellular
TgeneCACNA1Bchr9:134039531chr9:141006850ENST000003713723847357_4821809.33333333333332340.0Topological domainCytoplasmic
TgeneCACNA1Bchr9:134039531chr9:141006850ENST000003713723847502_5161809.33333333333332340.0Topological domainExtracellular
TgeneCACNA1Bchr9:134039531chr9:141006850ENST000003713723847537_5441809.33333333333332340.0Topological domainCytoplasmic
TgeneCACNA1Bchr9:134039531chr9:141006850ENST000003713723847563_5731809.33333333333332340.0Topological domainExtracellular
TgeneCACNA1Bchr9:134039531chr9:141006850ENST000003713723847593_6111809.33333333333332340.0Topological domainCytoplasmic
TgeneCACNA1Bchr9:134039531chr9:141006850ENST000003713723847632_6841809.33333333333332340.0Topological domainExtracellular
TgeneCACNA1Bchr9:134039531chr9:141006850ENST000003713723847710_11511809.33333333333332340.0Topological domainCytoplasmic
TgeneCACNA1Bchr9:134039531chr9:141006850ENST0000037137238471152_11691809.33333333333332340.0TransmembraneHelical%3B Name%3DS1 of repeat III
TgeneCACNA1Bchr9:134039531chr9:141006850ENST0000037137238471186_12051809.33333333333332340.0TransmembraneHelical%3B Name%3DS2 of repeat III
TgeneCACNA1Bchr9:134039531chr9:141006850ENST0000037137238471218_12361809.33333333333332340.0TransmembraneHelical%3B Name%3DS3 of repeat III
TgeneCACNA1Bchr9:134039531chr9:141006850ENST0000037137238471247_12651809.33333333333332340.0TransmembraneHelical%3B Name%3DS4 of repeat III
TgeneCACNA1Bchr9:134039531chr9:141006850ENST0000037137238471285_13041809.33333333333332340.0TransmembraneHelical%3B Name%3DS5 of repeat III
TgeneCACNA1Bchr9:134039531chr9:141006850ENST000003713723847133_1521809.33333333333332340.0TransmembraneHelical%3B Name%3DS2 of repeat I
TgeneCACNA1Bchr9:134039531chr9:141006850ENST0000037137238471392_14161809.33333333333332340.0TransmembraneHelical%3B Name%3DS6 of repeat III
TgeneCACNA1Bchr9:134039531chr9:141006850ENST0000037137238471472_14901809.33333333333332340.0TransmembraneHelical%3B Name%3DS1 of repeat IV
TgeneCACNA1Bchr9:134039531chr9:141006850ENST0000037137238471506_15251809.33333333333332340.0TransmembraneHelical%3B Name%3DS2 of repeat IV
TgeneCACNA1Bchr9:134039531chr9:141006850ENST0000037137238471534_15521809.33333333333332340.0TransmembraneHelical%3B Name%3DS3 of repeat IV
TgeneCACNA1Bchr9:134039531chr9:141006850ENST0000037137238471564_15821809.33333333333332340.0TransmembraneHelical%3B Name%3DS4 of repeat IV
TgeneCACNA1Bchr9:134039531chr9:141006850ENST0000037137238471602_16211809.33333333333332340.0TransmembraneHelical%3B Name%3DS5 of repeat IV
TgeneCACNA1Bchr9:134039531chr9:141006850ENST000003713723847164_1831809.33333333333332340.0TransmembraneHelical%3B Name%3DS3 of repeat I
TgeneCACNA1Bchr9:134039531chr9:141006850ENST0000037137238471684_17081809.33333333333332340.0TransmembraneHelical%3B Name%3DS6 of repeat IV
TgeneCACNA1Bchr9:134039531chr9:141006850ENST000003713723847188_2061809.33333333333332340.0TransmembraneHelical%3B Name%3DS4 of repeat I
TgeneCACNA1Bchr9:134039531chr9:141006850ENST000003713723847226_2451809.33333333333332340.0TransmembraneHelical%3B Name%3DS5 of repeat I
TgeneCACNA1Bchr9:134039531chr9:141006850ENST000003713723847332_3561809.33333333333332340.0TransmembraneHelical%3B Name%3DS6 of repeat I
TgeneCACNA1Bchr9:134039531chr9:141006850ENST000003713723847483_5011809.33333333333332340.0TransmembraneHelical%3B Name%3DS1 of repeat II
TgeneCACNA1Bchr9:134039531chr9:141006850ENST000003713723847517_5361809.33333333333332340.0TransmembraneHelical%3B Name%3DS2 of repeat II
TgeneCACNA1Bchr9:134039531chr9:141006850ENST000003713723847545_5621809.33333333333332340.0TransmembraneHelical%3B Name%3DS3 of repeat II
TgeneCACNA1Bchr9:134039531chr9:141006850ENST000003713723847574_5921809.33333333333332340.0TransmembraneHelical%3B Name%3DS4 of repeat II
TgeneCACNA1Bchr9:134039531chr9:141006850ENST000003713723847612_6311809.33333333333332340.0TransmembraneHelical%3B Name%3DS5 of repeat II
TgeneCACNA1Bchr9:134039531chr9:141006850ENST000003713723847685_7091809.33333333333332340.0TransmembraneHelical%3B Name%3DS6 of repeat II
TgeneCACNA1Bchr9:134039531chr9:141006850ENST00000371372384796_1141809.33333333333332340.0TransmembraneHelical%3B Name%3DS1 of repeat I


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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors
NUP214ZFP36, XPO1, NUP107, NXF2, NXF1, XPO5, CRM1, KAP104, IPO5, G3BP1, G3BP2, RAE1, APC, HDAC4, HDAC5, HDAC9, NUP88, SMAD1, Plk1, Nup88, Nup188, Nup214, CLEC4G, SMAD2, SMAD3, SMAD4, SIRT7, RANBP2, CUL3, CUL2, rev, NUPL2, NUP214, MEX67, ACOT13, PNPT1, HSPA1L, VPS4B, S100A6, EEF1A1, STRIP1, RPL19, NDUFA7, ITGA4, SOX2, LMNA, FBXO6, CUL7, OBSL1, NUP62, CLEC11A, DDX19A, KCMF1, CFL1, CSRP1, DYNC1LI1, TRIM28, TXNDC9, NTRK1, IFI16, NUP85, NUP35, KPNB1, UBE2I, NUPL1, NUP153, SEH1L, Ranbp2, Ube2i, Rcc1, Nup107, Kifc1, Nup155, Nup98, C11orf30, CDH1, RAN, FXR2, EMILIN1, SERPINB2, BRCA1, ORF10, CTNNB1, CUL4B, RNF31, ESR2, EZH2, SUZ12, MYC, CDK9, VCP, KIAA1429, NR2C2, HIST1H4A, PTPDC1, RHBDD1, RHBDF2, nsp9, BIRC3, LMBR1L, PLEKHA4, CYLD, ORF6, IMMP1L, IMMP2L, CTIF, DDX19B, GLE1, FARP1, Myo9b, ITSN1, PLEKHG6, ACACA, SUMO2, NFX1, NUPR1, DYRK1A, NUP155, SYNE3, NAA40, NXT2, SLFN11, CCNF, TAX1BP1, SIRT6, DVL2, ETV6,


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
NUP214all structure
CACNA1B


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to NUP214-CACNA1B


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to NUP214-CACNA1B


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneNUP214C0025958Microcephaly1GENOMICS_ENGLAND
HgeneNUP214C0543888Epileptic encephalopathy1GENOMICS_ENGLAND
HgeneNUP214C1836830Developmental regression1GENOMICS_ENGLAND
HgeneNUP214C1961099Precursor T-Cell Lymphoblastic Leukemia-Lymphoma1ORPHANET