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Center for Computational Systems Medicine level1
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:OXSR1-DAXX

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: OXSR1-DAXX
FusionPDB ID: 62053
FusionGDB2.0 ID: 62053
HgeneTgene
Gene symbol

OXSR1

DAXX

Gene ID

9943

1616

Gene nameoxidative stress responsive kinase 1death domain associated protein
SynonymsOSR1BING2|DAP6|EAP1|SMIM40
Cytomap

3p22.2

6p21.32

Type of geneprotein-codingprotein-coding
Descriptionserine/threonine-protein kinase OSR1oxidative stress responsive 1oxidative stress-responsive 1 proteindeath domain-associated protein 6CENP-C binding proteinETS1-associated protein 1Fas-binding proteindeath-associated protein 6fas death domain-associated protein
Modification date2020031320200313
UniProtAcc.

Q9UER7

Ensembl transtripts involved in fusion geneENST idsENST00000311806, ENST00000446845, 
ENST00000492714, 		ENST00000383062, 
ENST00000383194, ENST00000399060, 
ENST00000399344, ENST00000414388, 
ENST00000433482, ENST00000436311, 
ENST00000445009, ENST00000455860, 
ENST00000461796, ENST00000469277, 
ENST00000472399, ENST00000477162, 
ENST00000494562, ENST00000266000, 
ENST00000374542, ENST00000414083, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score9 X 10 X 8=7207 X 4 X 5=140
# samples 127
** MAII scorelog2(12/720*10)=-2.58496250072116
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(7/140*10)=-1
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: OXSR1 [Title/Abstract] AND DAXX [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)OXSR1(38294368)-DAXX(33286940), # samples:1
Anticipated loss of major functional domain due to fusion event.OXSR1-DAXX seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
OXSR1-DAXX seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
OXSR1-DAXX seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
OXSR1-DAXX seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneOXSR1

GO:0006468

protein phosphorylation

14707132

HgeneOXSR1

GO:0018107

peptidyl-threonine phosphorylation

24393035

HgeneOXSR1

GO:0035556

intracellular signal transduction

14707132

HgeneOXSR1

GO:0046777

protein autophosphorylation

22052202

TgeneDAXX

GO:0006334

nucleosome assembly

20504901|20651253

TgeneDAXX

GO:0006338

chromatin remodeling

20651253

TgeneDAXX

GO:0006355

regulation of transcription, DNA-templated

15878163

TgeneDAXX

GO:0030521

androgen receptor signaling pathway

15572661

TgeneDAXX

GO:0031396

regulation of protein ubiquitination

18566590

TgeneDAXX

GO:0034605

cellular response to heat

15016915

TgeneDAXX

GO:0034620

cellular response to unfolded protein

15016915

TgeneDAXX

GO:0045892

negative regulation of transcription, DNA-templated

12140263|15572661

TgeneDAXX

GO:0071276

cellular response to cadmium ion

15016915

TgeneDAXX

GO:0071280

cellular response to copper ion

15016915

TgeneDAXX

GO:0072738

cellular response to diamide

15016915

TgeneDAXX

GO:1903936

cellular response to sodium arsenite

15016915


check buttonFusion gene breakpoints across OXSR1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across DAXX (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS5.0N/ABG114042OXSR1chr3

38294368

+DAXXchr6

33286940

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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000311806OXSR1chr338294368+ENST00000266000DAXXchr633286940-490444922012084627
ENST00000311806OXSR1chr338294368+ENST00000374542DAXXchr633286940-490444922012084627
ENST00000311806OXSR1chr338294368+ENST00000414083DAXXchr633286940-474344922012084627

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000311806ENST00000266000OXSR1chr338294368+DAXXchr633286940-0.000508080.99949193
ENST00000311806ENST00000374542OXSR1chr338294368+DAXXchr633286940-0.000508080.99949193
ENST00000311806ENST00000414083OXSR1chr338294368+DAXXchr633286940-0.0006360450.99936396

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>62053_62053_1_OXSR1-DAXX_OXSR1_chr3_38294368_ENST00000311806_DAXX_chr6_33286940_ENST00000266000_length(amino acids)=627AA_BP=
MPRGDPAPRRRPTRGCSETIGGGAAAAAAAVGGGETRGEETSEVSEFEGGPRAAAAVMSEDSSALPWSINRDDYELQEVIGSGATAVVQA
AYCAPKKEKVAIKRINLEKCQTSMDELLKEIQAMSQCHHPNIVSYYTSFVVKDELWLVMKLLSGGSVLDIIKHIVAKGEHKSGVLDESTI
ATILREVLEGLEYLHKNGQIHRDVKAGNILLGEDGSVQIADFGVSAFLATGGDITRNKVRKTFVGTPCWMAPEVMEQVRGYDFKADIWSF
GITAIELATGAAPYHKYPPMKVLMLTLQNDPPSLETGVQDKEMLKKYGKSFRKMISLCLQKDPEKRPTAAELLRHKFFQKAKNKEFLQEK
TLQRAPTISERAKKVRRVPGSSGRLHKTEDGGWEWSDDEFDEESEEGKAAISQLRSPRVKESISNSELFPTTDPVGTLLQVPEQISAHLP
QPAGQIATQPTQVSLPPTAEPAKTAQALSSGSGSQETKIPISLVLRLRNSKKELNDIRFEFTPGRDTAEGVSQELISAGLVDGRDLVIVA

--------------------------------------------------------------

>62053_62053_2_OXSR1-DAXX_OXSR1_chr3_38294368_ENST00000311806_DAXX_chr6_33286940_ENST00000374542_length(amino acids)=627AA_BP=
MPRGDPAPRRRPTRGCSETIGGGAAAAAAAVGGGETRGEETSEVSEFEGGPRAAAAVMSEDSSALPWSINRDDYELQEVIGSGATAVVQA
AYCAPKKEKVAIKRINLEKCQTSMDELLKEIQAMSQCHHPNIVSYYTSFVVKDELWLVMKLLSGGSVLDIIKHIVAKGEHKSGVLDESTI
ATILREVLEGLEYLHKNGQIHRDVKAGNILLGEDGSVQIADFGVSAFLATGGDITRNKVRKTFVGTPCWMAPEVMEQVRGYDFKADIWSF
GITAIELATGAAPYHKYPPMKVLMLTLQNDPPSLETGVQDKEMLKKYGKSFRKMISLCLQKDPEKRPTAAELLRHKFFQKAKNKEFLQEK
TLQRAPTISERAKKVRRVPGSSGRLHKTEDGGWEWSDDEFDEESEEGKAAISQLRSPRVKESISNSELFPTTDPVGTLLQVPEQISAHLP
QPAGQIATQPTQVSLPPTAEPAKTAQALSSGSGSQETKIPISLVLRLRNSKKELNDIRFEFTPGRDTAEGVSQELISAGLVDGRDLVIVA

--------------------------------------------------------------

>62053_62053_3_OXSR1-DAXX_OXSR1_chr3_38294368_ENST00000311806_DAXX_chr6_33286940_ENST00000414083_length(amino acids)=627AA_BP=
MPRGDPAPRRRPTRGCSETIGGGAAAAAAAVGGGETRGEETSEVSEFEGGPRAAAAVMSEDSSALPWSINRDDYELQEVIGSGATAVVQA
AYCAPKKEKVAIKRINLEKCQTSMDELLKEIQAMSQCHHPNIVSYYTSFVVKDELWLVMKLLSGGSVLDIIKHIVAKGEHKSGVLDESTI
ATILREVLEGLEYLHKNGQIHRDVKAGNILLGEDGSVQIADFGVSAFLATGGDITRNKVRKTFVGTPCWMAPEVMEQVRGYDFKADIWSF
GITAIELATGAAPYHKYPPMKVLMLTLQNDPPSLETGVQDKEMLKKYGKSFRKMISLCLQKDPEKRPTAAELLRHKFFQKAKNKEFLQEK
TLQRAPTISERAKKVRRVPGSSGRLHKTEDGGWEWSDDEFDEESEEGKAAISQLRSPRVKESISNSELFPTTDPVGTLLQVPEQISAHLP
QPAGQIATQPTQVSLPPTAEPAKTAQALSSGSGSQETKIPISLVLRLRNSKKELNDIRFEFTPGRDTAEGVSQELISAGLVDGRDLVIVA

--------------------------------------------------------------

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr3:38294368/chr6:33286940)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.DAXX

Q9UER7

FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Transcription corepressor known to repress transcriptional potential of several sumoylated transcription factors. Down-regulates basal and activated transcription. Its transcription repressor activity is modulated by recruiting it to subnuclear compartments like the nucleolus or PML/POD/ND10 nuclear bodies through interactions with MCSR1 and PML, respectively. Seems to regulate transcription in PML/POD/ND10 nuclear bodies together with PML and may influence TNFRSF6-dependent apoptosis thereby. Inhibits transcriptional activation of PAX3 and ETS1 through direct protein-protein interactions. Modulates PAX5 activity; the function seems to involve CREBBP. Acts as an adapter protein in a MDM2-DAXX-USP7 complex by regulating the RING-finger E3 ligase MDM2 ubiquitination activity. Under non-stress condition, in association with the deubiquitinating USP7, prevents MDM2 self-ubiquitination and enhances the intrinsic E3 ligase activity of MDM2 towards TP53, thereby promoting TP53 ubiquitination and subsequent proteasomal degradation. Upon DNA damage, its association with MDM2 and USP7 is disrupted, resulting in increased MDM2 autoubiquitination and consequently, MDM2 degradation, which leads to TP53 stabilization. Acts as histone chaperone that facilitates deposition of histone H3.3. Acts as targeting component of the chromatin remodeling complex ATRX:DAXX which has ATP-dependent DNA translocase activity and catalyzes the replication-independent deposition of histone H3.3 in pericentric DNA repeats outside S-phase and telomeres, and the in vitro remodeling of H3.3-containing nucleosomes. Does not affect the ATPase activity of ATRX but alleviates its transcription repression activity. Upon neuronal activation associates with regulatory elements of selected immediate early genes where it promotes deposition of histone H3.3 which may be linked to transcriptional induction of these genes. Required for the recruitment of histone H3.3:H4 dimers to PML-nuclear bodies (PML-NBs); the process is independent of ATRX and facilitated by ASF1A; PML-NBs are suggested to function as regulatory sites for the incorporation of newly synthesized histone H3.3 into chromatin. In case of overexpression of centromeric histone variant CENPA (as found in various tumors) is involved in its mislocalization to chromosomes; the ectopic localization involves a heterotypic tetramer containing CENPA, and histones H3.3 and H4 and decreases binding of CTCF to chromatin. Proposed to mediate activation of the JNK pathway and apoptosis via MAP3K5 in response to signaling from TNFRSF6 and TGFBR2. Interaction with HSPB1/HSP27 may prevent interaction with TNFRSF6 and MAP3K5 and block DAXX-mediated apoptosis. In contrast, in lymphoid cells JNC activation and TNFRSF6-mediated apoptosis may not involve DAXX. Shows restriction activity towards human cytomegalovirus (HCMV). Plays a role as a positive regulator of the heat shock transcription factor HSF1 activity during the stress protein response (PubMed:15016915). {ECO:0000269|PubMed:12140263, ECO:0000269|PubMed:14990586, ECO:0000269|PubMed:15016915, ECO:0000269|PubMed:15364927, ECO:0000269|PubMed:16845383, ECO:0000269|PubMed:17081986, ECO:0000269|PubMed:17942542, ECO:0000269|PubMed:20504901, ECO:0000269|PubMed:20651253, ECO:0000269|PubMed:23222847, ECO:0000269|PubMed:24200965, ECO:0000269|PubMed:24530302}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneDAXXchr3:38294368chr6:33286940ENST0000026600008180_2170741.0Coiled coilOntology_term=ECO:0000255
TgeneDAXXchr3:38294368chr6:33286940ENST0000026600008358_3990741.0Coiled coilOntology_term=ECO:0000255
TgeneDAXXchr3:38294368chr6:33286940ENST0000026600008430_4890741.0Coiled coilOntology_term=ECO:0000255
TgeneDAXXchr3:38294368chr6:33286940ENST0000037454208180_2170741.0Coiled coilOntology_term=ECO:0000255
TgeneDAXXchr3:38294368chr6:33286940ENST0000037454208358_3990741.0Coiled coilOntology_term=ECO:0000255
TgeneDAXXchr3:38294368chr6:33286940ENST0000037454208430_4890741.0Coiled coilOntology_term=ECO:0000255
TgeneDAXXchr3:38294368chr6:33286940ENST0000038306208180_2170741.0Coiled coilOntology_term=ECO:0000255
TgeneDAXXchr3:38294368chr6:33286940ENST0000038306208358_3990741.0Coiled coilOntology_term=ECO:0000255
TgeneDAXXchr3:38294368chr6:33286940ENST0000038306208430_4890741.0Coiled coilOntology_term=ECO:0000255
TgeneDAXXchr3:38294368chr6:33286940ENST0000038319408180_2170741.0Coiled coilOntology_term=ECO:0000255
TgeneDAXXchr3:38294368chr6:33286940ENST0000038319408358_3990741.0Coiled coilOntology_term=ECO:0000255
TgeneDAXXchr3:38294368chr6:33286940ENST0000038319408430_4890741.0Coiled coilOntology_term=ECO:0000255
TgeneDAXXchr3:38294368chr6:33286940ENST0000039906008180_2170741.0Coiled coilOntology_term=ECO:0000255
TgeneDAXXchr3:38294368chr6:33286940ENST0000039906008358_3990741.0Coiled coilOntology_term=ECO:0000255
TgeneDAXXchr3:38294368chr6:33286940ENST0000039906008430_4890741.0Coiled coilOntology_term=ECO:0000255
TgeneDAXXchr3:38294368chr6:33286940ENST0000039934408180_2170741.0Coiled coilOntology_term=ECO:0000255
TgeneDAXXchr3:38294368chr6:33286940ENST0000039934408358_3990741.0Coiled coilOntology_term=ECO:0000255
TgeneDAXXchr3:38294368chr6:33286940ENST0000039934408430_4890741.0Coiled coilOntology_term=ECO:0000255
TgeneDAXXchr3:38294368chr6:33286940ENST0000041408307180_2170666.0Coiled coilOntology_term=ECO:0000255
TgeneDAXXchr3:38294368chr6:33286940ENST0000041408307358_3990666.0Coiled coilOntology_term=ECO:0000255
TgeneDAXXchr3:38294368chr6:33286940ENST0000041408307430_4890666.0Coiled coilOntology_term=ECO:0000255
TgeneDAXXchr3:38294368chr6:33286940ENST0000043348208180_2170741.0Coiled coilOntology_term=ECO:0000255
TgeneDAXXchr3:38294368chr6:33286940ENST0000043348208358_3990741.0Coiled coilOntology_term=ECO:0000255
TgeneDAXXchr3:38294368chr6:33286940ENST0000043348208430_4890741.0Coiled coilOntology_term=ECO:0000255
TgeneDAXXchr3:38294368chr6:33286940ENST0000043631108180_2170741.0Coiled coilOntology_term=ECO:0000255
TgeneDAXXchr3:38294368chr6:33286940ENST0000043631108358_3990741.0Coiled coilOntology_term=ECO:0000255
TgeneDAXXchr3:38294368chr6:33286940ENST0000043631108430_4890741.0Coiled coilOntology_term=ECO:0000255
TgeneDAXXchr3:38294368chr6:33286940ENST0000044500908180_2170741.0Coiled coilOntology_term=ECO:0000255
TgeneDAXXchr3:38294368chr6:33286940ENST0000044500908358_3990741.0Coiled coilOntology_term=ECO:0000255
TgeneDAXXchr3:38294368chr6:33286940ENST0000044500908430_4890741.0Coiled coilOntology_term=ECO:0000255
TgeneDAXXchr3:38294368chr6:33286940ENST0000045586008180_2170741.0Coiled coilOntology_term=ECO:0000255
TgeneDAXXchr3:38294368chr6:33286940ENST0000045586008358_3990741.0Coiled coilOntology_term=ECO:0000255
TgeneDAXXchr3:38294368chr6:33286940ENST0000045586008430_4890741.0Coiled coilOntology_term=ECO:0000255
TgeneDAXXchr3:38294368chr6:33286940ENST000002660000811_160741.0Compositional biasNote=Poly-Asp
TgeneDAXXchr3:38294368chr6:33286940ENST0000026600008434_5720741.0Compositional biasNote=Asp/Glu-rich (acidic)
TgeneDAXXchr3:38294368chr6:33286940ENST000003745420811_160741.0Compositional biasNote=Poly-Asp
TgeneDAXXchr3:38294368chr6:33286940ENST0000037454208434_5720741.0Compositional biasNote=Asp/Glu-rich (acidic)
TgeneDAXXchr3:38294368chr6:33286940ENST000003830620811_160741.0Compositional biasNote=Poly-Asp
TgeneDAXXchr3:38294368chr6:33286940ENST0000038306208434_5720741.0Compositional biasNote=Asp/Glu-rich (acidic)
TgeneDAXXchr3:38294368chr6:33286940ENST000003831940811_160741.0Compositional biasNote=Poly-Asp
TgeneDAXXchr3:38294368chr6:33286940ENST0000038319408434_5720741.0Compositional biasNote=Asp/Glu-rich (acidic)
TgeneDAXXchr3:38294368chr6:33286940ENST000003990600811_160741.0Compositional biasNote=Poly-Asp
TgeneDAXXchr3:38294368chr6:33286940ENST0000039906008434_5720741.0Compositional biasNote=Asp/Glu-rich (acidic)
TgeneDAXXchr3:38294368chr6:33286940ENST000003993440811_160741.0Compositional biasNote=Poly-Asp
TgeneDAXXchr3:38294368chr6:33286940ENST0000039934408434_5720741.0Compositional biasNote=Asp/Glu-rich (acidic)
TgeneDAXXchr3:38294368chr6:33286940ENST000004140830711_160666.0Compositional biasNote=Poly-Asp
TgeneDAXXchr3:38294368chr6:33286940ENST0000041408307434_5720666.0Compositional biasNote=Asp/Glu-rich (acidic)
TgeneDAXXchr3:38294368chr6:33286940ENST000004334820811_160741.0Compositional biasNote=Poly-Asp
TgeneDAXXchr3:38294368chr6:33286940ENST0000043348208434_5720741.0Compositional biasNote=Asp/Glu-rich (acidic)
TgeneDAXXchr3:38294368chr6:33286940ENST000004363110811_160741.0Compositional biasNote=Poly-Asp
TgeneDAXXchr3:38294368chr6:33286940ENST0000043631108434_5720741.0Compositional biasNote=Asp/Glu-rich (acidic)
TgeneDAXXchr3:38294368chr6:33286940ENST000004450090811_160741.0Compositional biasNote=Poly-Asp
TgeneDAXXchr3:38294368chr6:33286940ENST0000044500908434_5720741.0Compositional biasNote=Asp/Glu-rich (acidic)
TgeneDAXXchr3:38294368chr6:33286940ENST000004558600811_160741.0Compositional biasNote=Poly-Asp
TgeneDAXXchr3:38294368chr6:33286940ENST0000045586008434_5720741.0Compositional biasNote=Asp/Glu-rich (acidic)
TgeneDAXXchr3:38294368chr6:33286940ENST0000026600008391_3950741.0MotifNuclear localization signal
TgeneDAXXchr3:38294368chr6:33286940ENST0000026600008628_6340741.0MotifNuclear localization signal
TgeneDAXXchr3:38294368chr6:33286940ENST0000037454208391_3950741.0MotifNuclear localization signal
TgeneDAXXchr3:38294368chr6:33286940ENST0000037454208628_6340741.0MotifNuclear localization signal
TgeneDAXXchr3:38294368chr6:33286940ENST0000038306208391_3950741.0MotifNuclear localization signal
TgeneDAXXchr3:38294368chr6:33286940ENST0000038306208628_6340741.0MotifNuclear localization signal
TgeneDAXXchr3:38294368chr6:33286940ENST0000038319408391_3950741.0MotifNuclear localization signal
TgeneDAXXchr3:38294368chr6:33286940ENST0000038319408628_6340741.0MotifNuclear localization signal
TgeneDAXXchr3:38294368chr6:33286940ENST0000039906008391_3950741.0MotifNuclear localization signal
TgeneDAXXchr3:38294368chr6:33286940ENST0000039906008628_6340741.0MotifNuclear localization signal
TgeneDAXXchr3:38294368chr6:33286940ENST0000039934408391_3950741.0MotifNuclear localization signal
TgeneDAXXchr3:38294368chr6:33286940ENST0000039934408628_6340741.0MotifNuclear localization signal
TgeneDAXXchr3:38294368chr6:33286940ENST0000041408307391_3950666.0MotifNuclear localization signal
TgeneDAXXchr3:38294368chr6:33286940ENST0000041408307628_6340666.0MotifNuclear localization signal
TgeneDAXXchr3:38294368chr6:33286940ENST0000043348208391_3950741.0MotifNuclear localization signal
TgeneDAXXchr3:38294368chr6:33286940ENST0000043348208628_6340741.0MotifNuclear localization signal
TgeneDAXXchr3:38294368chr6:33286940ENST0000043631108391_3950741.0MotifNuclear localization signal
TgeneDAXXchr3:38294368chr6:33286940ENST0000043631108628_6340741.0MotifNuclear localization signal
TgeneDAXXchr3:38294368chr6:33286940ENST0000044500908391_3950741.0MotifNuclear localization signal
TgeneDAXXchr3:38294368chr6:33286940ENST0000044500908628_6340741.0MotifNuclear localization signal
TgeneDAXXchr3:38294368chr6:33286940ENST0000045586008391_3950741.0MotifNuclear localization signal
TgeneDAXXchr3:38294368chr6:33286940ENST0000045586008628_6340741.0MotifNuclear localization signal

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneOXSR1chr3:38294368chr6:33286940ENST00000311806+11817_2910528.0DomainProtein kinase
HgeneOXSR1chr3:38294368chr6:33286940ENST00000311806+11823_310528.0Nucleotide bindingATP


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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
OXSR1
DAXX


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to OXSR1-DAXX


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to OXSR1-DAXX


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource