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Center for Computational Systems Medicine level1
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:ARHGEF12-CNTN5

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: ARHGEF12-CNTN5
FusionPDB ID: 6208
FusionGDB2.0 ID: 6208
HgeneTgene
Gene symbol

ARHGEF12

CNTN5

Gene ID

23365

53942

Gene nameRho guanine nucleotide exchange factor 12contactin 5
SynonymsLARG|PRO2792HNB-2s|NB-2
Cytomap

11q23.3

11q22.1

Type of geneprotein-codingprotein-coding
Descriptionrho guanine nucleotide exchange factor 12Rho guanine nucleotide exchange factor (GEF) 12leukemia-associated RhoGEFleukemia-associated rho guanine nucleotide exchange factorcontactin-5neural adhesion moleculeneural recognition molecule NB-2
Modification date2020031320200329
UniProtAcc

Q9NZN5

O94779

Ensembl transtripts involved in fusion geneENST idsENST00000356641, ENST00000397843, 
ENST00000532993, 		ENST00000524560, 
ENST00000279463, ENST00000418526, 
ENST00000524871, ENST00000527185, 
ENST00000528682, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score16 X 13 X 9=187218 X 15 X 12=3240
# samples 2119
** MAII scorelog2(21/1872*10)=-3.15611920191728
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(19/3240*10)=-4.09192248944104
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: ARHGEF12 [Title/Abstract] AND CNTN5 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)ARHGEF12(120278532)-CNTN5(99786786), # samples:1
ARHGEF12(120280159)-CNTN5(99786786), # samples:1
Anticipated loss of major functional domain due to fusion event.ARHGEF12-CNTN5 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ARHGEF12-CNTN5 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ARHGEF12-CNTN5 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
ARHGEF12-CNTN5 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneARHGEF12

GO:0007186

G protein-coupled receptor signaling pathway

15755723


check buttonFusion gene breakpoints across ARHGEF12 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across CNTN5 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LUADTCGA-55-6642-01AARHGEF12chr11

120278532

+CNTN5chr11

99786786

+
ChimerDB4LUADTCGA-55-6642-01AARHGEF12chr11

120280159

-CNTN5chr11

99786786

+


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000397843ARHGEF12chr11120278532+ENST00000527185CNTN5chr1199786786+36953081662466766
ENST00000397843ARHGEF12chr11120278532+ENST00000528682CNTN5chr1199786786+33803081663033955
ENST00000397843ARHGEF12chr11120278532+ENST00000524871CNTN5chr1199786786+56993081663033955
ENST00000397843ARHGEF12chr11120278532+ENST00000418526CNTN5chr1199786786+35563081663033955
ENST00000397843ARHGEF12chr11120278532+ENST00000279463CNTN5chr1199786786+30343081663033956
ENST00000356641ARHGEF12chr11120278532+ENST00000527185CNTN5chr1199786786+353614972307766
ENST00000356641ARHGEF12chr11120278532+ENST00000528682CNTN5chr1199786786+322114972874955
ENST00000356641ARHGEF12chr11120278532+ENST00000524871CNTN5chr1199786786+554014972874955
ENST00000356641ARHGEF12chr11120278532+ENST00000418526CNTN5chr1199786786+339714972874955
ENST00000356641ARHGEF12chr11120278532+ENST00000279463CNTN5chr1199786786+287514972874956
ENST00000397843ARHGEF12chr11120280159-ENST00000527185CNTN5chr1199786786+37523651662523785
ENST00000397843ARHGEF12chr11120280159-ENST00000528682CNTN5chr1199786786+34373651663090974
ENST00000397843ARHGEF12chr11120280159-ENST00000524871CNTN5chr1199786786+57563651663090974
ENST00000397843ARHGEF12chr11120280159-ENST00000418526CNTN5chr1199786786+36133651663090974
ENST00000397843ARHGEF12chr11120280159-ENST00000279463CNTN5chr1199786786+30913651663090975

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000397843ENST00000527185ARHGEF12chr11120278532+CNTN5chr1199786786+0.0002250040.999775
ENST00000397843ENST00000528682ARHGEF12chr11120278532+CNTN5chr1199786786+0.0001667030.9998332
ENST00000397843ENST00000524871ARHGEF12chr11120278532+CNTN5chr1199786786+8.97E-050.99991035
ENST00000397843ENST00000418526ARHGEF12chr11120278532+CNTN5chr1199786786+0.0001605730.9998394
ENST00000397843ENST00000279463ARHGEF12chr11120278532+CNTN5chr1199786786+0.0002919380.999708
ENST00000356641ENST00000527185ARHGEF12chr11120278532+CNTN5chr1199786786+0.0002490790.9997509
ENST00000356641ENST00000528682ARHGEF12chr11120278532+CNTN5chr1199786786+0.000199980.9998
ENST00000356641ENST00000524871ARHGEF12chr11120278532+CNTN5chr1199786786+9.45E-050.99990547
ENST00000356641ENST00000418526ARHGEF12chr11120278532+CNTN5chr1199786786+0.0001865650.9998135
ENST00000356641ENST00000279463ARHGEF12chr11120278532+CNTN5chr1199786786+0.0003768310.9996232
ENST00000397843ENST00000527185ARHGEF12chr11120280159-CNTN5chr1199786786+5.71E-050.9999429
ENST00000397843ENST00000528682ARHGEF12chr11120280159-CNTN5chr1199786786+6.44E-050.9999356
ENST00000397843ENST00000524871ARHGEF12chr11120280159-CNTN5chr1199786786+2.78E-050.9999722
ENST00000397843ENST00000418526ARHGEF12chr11120280159-CNTN5chr1199786786+6.21E-050.9999379
ENST00000397843ENST00000279463ARHGEF12chr11120280159-CNTN5chr1199786786+0.0001210570.9998789

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>6208_6208_1_ARHGEF12-CNTN5_ARHGEF12_chr11_120278532_ENST00000356641_CNTN5_chr11_99786786_ENST00000279463_length(amino acids)=956AA_BP=46
MSGTQSTITDRFPLKKPIRHGSILNRESPTDKKQKVERIASHDFDPTDLGNFSGRTRSAVSVREGQGVVLMCSPPPHSPEIIYSWVFNEF
PSFVAEDSRRFISQETGNLYISKVQTSDVGSYICLVKNTVTNARVLSPPTPLTLRNDGVMGEYEPKIEVHFPFTVTAAKGTTVKMECFAL
GNPVPTITWMKVNGYIPSKARLRKSQAVLEIPNVQLDDAGIYECRAENSRGKNSFRGQLQVYTYPHWVEKLNDTQLDSGSPLRWECKATG
KPRPTYRWLKNGVPLSPQSRVEMVNGVLMIHNVNQSDAGMYQCLAENKYGAIYASAELKILASAPTFALNQLKKTIIVTKDQEVVIECKP
QGSPKPTISWKKGDRAVRENKRIAILPDGSLRILNASKSDEGKYVCRGENVFGSAEIIASLSVKEPTRIELTPKRTELTVGESIVLNCKA
IHDASLDVTFYWTLKGQPIDFEEEGGHFESIRAQASSADLMIRNILLMHAGRYGCRVQTTADSVSDEAELLVRGPPGPPGIVIVEEITES
TATLSWSPAADNHSPISSYNLQARSPFSLGWQTVKTVPEIITGDMESAMAVDLNPWVEYEFRVVATNPIGTGDPSTPSRMIRTNEAVPKT
APTNVSGRSGRRHELVIAWEPVSEEFQNGEGFGYIVAFRPNGTRGWKEKMVTSSEASKFIYRDESVPPLTPFEVKVGVYNNKGDGPFSQI
VVICSAEGEPSAAPTDVKATSVSVSEILVAWKHIKESLGRPQGFEVGYWKDMEQEDTAETVKTRGNESFVILTGLEGNTLYHFTVRAYNG
AGYGPPSSEVSATTKKSPPSQAPSNLRWEQQGSQVSLGWEPVIPLANESEVVGYKVFYRQEGHSNSQVIETQKLQAVVPLPDAGVYIIEV

--------------------------------------------------------------

>6208_6208_2_ARHGEF12-CNTN5_ARHGEF12_chr11_120278532_ENST00000356641_CNTN5_chr11_99786786_ENST00000418526_length(amino acids)=955AA_BP=46
MSGTQSTITDRFPLKKPIRHGSILNRESPTDKKQKVERIASHDFDPTDLGNFSGRTRSAVSVREGQGVVLMCSPPPHSPEIIYSWVFNEF
PSFVAEDSRRFISQETGNLYISKVQTSDVGSYICLVKNTVTNARVLSPPTPLTLRNDGVMGEYEPKIEVHFPFTVTAAKGTTVKMECFAL
GNPVPTITWMKVNGYIPSKARLRKSQAVLEIPNVQLDDAGIYECRAENSRGKNSFRGQLQVYTYPHWVEKLNDTQLDSGSPLRWECKATG
KPRPTYRWLKNGVPLSPQSRVEMVNGVLMIHNVNQSDAGMYQCLAENKYGAIYASAELKILASAPTFALNQLKKTIIVTKDQEVVIECKP
QGSPKPTISWKKGDRAVRENKRIAILPDGSLRILNASKSDEGKYVCRGENVFGSAEIIASLSVKEPTRIELTPKRTELTVGESIVLNCKA
IHDASLDVTFYWTLKGQPIDFEEEGGHFESIRAQASSADLMIRNILLMHAGRYGCRVQTTADSVSDEAELLVRGPPGPPGIVIVEEITES
TATLSWSPAADNHSPISSYNLQARSPFSLGWQTVKTVPEIITGDMESAMAVDLNPWVEYEFRVVATNPIGTGDPSTPSRMIRTNEAVPKT
APTNVSGRSGRRHELVIAWEPVSEEFQNGEGFGYIVAFRPNGTRGWKEKMVTSSEASKFIYRDESVPPLTPFEVKVGVYNNKGDGPFSQI
VVICSAEGEPSAAPTDVKATSVSVSEILVAWKHIKESLGRPQGFEVGYWKDMEQEDTAETVKTRGNESFVILTGLEGNTLYHFTVRAYNG
AGYGPPSSEVSATTKKSPPSQAPSNLRWEQQGSQVSLGWEPVIPLANESEVVGYKVFYRQEGHSNSQVIETQKLQAVVPLPDAGVYIIEV

--------------------------------------------------------------

>6208_6208_3_ARHGEF12-CNTN5_ARHGEF12_chr11_120278532_ENST00000356641_CNTN5_chr11_99786786_ENST00000524871_length(amino acids)=955AA_BP=46
MSGTQSTITDRFPLKKPIRHGSILNRESPTDKKQKVERIASHDFDPTDLGNFSGRTRSAVSVREGQGVVLMCSPPPHSPEIIYSWVFNEF
PSFVAEDSRRFISQETGNLYISKVQTSDVGSYICLVKNTVTNARVLSPPTPLTLRNDGVMGEYEPKIEVHFPFTVTAAKGTTVKMECFAL
GNPVPTITWMKVNGYIPSKARLRKSQAVLEIPNVQLDDAGIYECRAENSRGKNSFRGQLQVYTYPHWVEKLNDTQLDSGSPLRWECKATG
KPRPTYRWLKNGVPLSPQSRVEMVNGVLMIHNVNQSDAGMYQCLAENKYGAIYASAELKILASAPTFALNQLKKTIIVTKDQEVVIECKP
QGSPKPTISWKKGDRAVRENKRIAILPDGSLRILNASKSDEGKYVCRGENVFGSAEIIASLSVKEPTRIELTPKRTELTVGESIVLNCKA
IHDASLDVTFYWTLKGQPIDFEEEGGHFESIRAQASSADLMIRNILLMHAGRYGCRVQTTADSVSDEAELLVRGPPGPPGIVIVEEITES
TATLSWSPAADNHSPISSYNLQARSPFSLGWQTVKTVPEIITGDMESAMAVDLNPWVEYEFRVVATNPIGTGDPSTPSRMIRTNEAVPKT
APTNVSGRSGRRHELVIAWEPVSEEFQNGEGFGYIVAFRPNGTRGWKEKMVTSSEASKFIYRDESVPPLTPFEVKVGVYNNKGDGPFSQI
VVICSAEGEPSAAPTDVKATSVSVSEILVAWKHIKESLGRPQGFEVGYWKDMEQEDTAETVKTRGNESFVILTGLEGNTLYHFTVRAYNG
AGYGPPSSEVSATTKKSPPSQAPSNLRWEQQGSQVSLGWEPVIPLANESEVVGYKVFYRQEGHSNSQVIETQKLQAVVPLPDAGVYIIEV

--------------------------------------------------------------

>6208_6208_4_ARHGEF12-CNTN5_ARHGEF12_chr11_120278532_ENST00000356641_CNTN5_chr11_99786786_ENST00000527185_length(amino acids)=766AA_BP=46
MSGTQSTITDRFPLKKPIRHGSILNRESPTDKKQKVERIASHDFDPTDLGNFSGRTRSAVSVREGQGVVLMCSPPPHSPEIIYSWVFNEF
PSFVAEDSRRFISQETGNLYISKVQTSDVGSYICLVKNTVTNARVLSPPTPLTLRNDGVMGEYEPKIEVHFPFTVTAAKGTTVKMECFAL
GNPVPTITWMKVNGYIPSKARLRKSQAVLEIPNVQLDDAGIYECRAENSRGKNSFRGQLQVYTYPHWVEKLNDTQLDSGSPLRWECKATG
KPRPTYRWLKNGVPLSPQSRVEMVNGVLMIHNVNQSDAGMYQCLAENKYGAIYASAELKILASAPTFALNQLKKTIIVTKDQEVVIECKP
QGSPKPTISWKKGDRAVRENKRIAILPDGSLRILNASKSDEGKYVCRGENVFGSAEIIASLSVKEPTRIELTPKRTELTVGESIVLNCKA
IHDASLDVTFYWTLKGQPIDFEEEGGHFESIRAQASSADLMIRNILLMHAGRYGCRVQTTADSVSDEAELLVRGPPGPPGIVIVEEITES
TATLSWSPAADNHSPISSYNLQARSPFSLGWQTVKTVPEIITGDMESAMAVDLNPWVEYEFRVVATNPIGTGDPSTPSRMIRTNEAVPKT
APTNVSGRSGRRHELVIAWEPVSEEFQNGEGFGYIVAFRPNGTRGWKEKMVTSSEASKFIYRDESVPPLTPFEVKVGVYNNKGDGPFSQI

--------------------------------------------------------------

>6208_6208_5_ARHGEF12-CNTN5_ARHGEF12_chr11_120278532_ENST00000356641_CNTN5_chr11_99786786_ENST00000528682_length(amino acids)=955AA_BP=46
MSGTQSTITDRFPLKKPIRHGSILNRESPTDKKQKVERIASHDFDPTDLGNFSGRTRSAVSVREGQGVVLMCSPPPHSPEIIYSWVFNEF
PSFVAEDSRRFISQETGNLYISKVQTSDVGSYICLVKNTVTNARVLSPPTPLTLRNDGVMGEYEPKIEVHFPFTVTAAKGTTVKMECFAL
GNPVPTITWMKVNGYIPSKARLRKSQAVLEIPNVQLDDAGIYECRAENSRGKNSFRGQLQVYTYPHWVEKLNDTQLDSGSPLRWECKATG
KPRPTYRWLKNGVPLSPQSRVEMVNGVLMIHNVNQSDAGMYQCLAENKYGAIYASAELKILASAPTFALNQLKKTIIVTKDQEVVIECKP
QGSPKPTISWKKGDRAVRENKRIAILPDGSLRILNASKSDEGKYVCRGENVFGSAEIIASLSVKEPTRIELTPKRTELTVGESIVLNCKA
IHDASLDVTFYWTLKGQPIDFEEEGGHFESIRAQASSADLMIRNILLMHAGRYGCRVQTTADSVSDEAELLVRGPPGPPGIVIVEEITES
TATLSWSPAADNHSPISSYNLQARSPFSLGWQTVKTVPEIITGDMESAMAVDLNPWVEYEFRVVATNPIGTGDPSTPSRMIRTNEAVPKT
APTNVSGRSGRRHELVIAWEPVSEEFQNGEGFGYIVAFRPNGTRGWKEKMVTSSEASKFIYRDESVPPLTPFEVKVGVYNNKGDGPFSQI
VVICSAEGEPSAAPTDVKATSVSVSEILVAWKHIKESLGRPQGFEVGYWKDMEQEDTAETVKTRGNESFVILTGLEGNTLYHFTVRAYNG
AGYGPPSSEVSATTKKSPPSQAPSNLRWEQQGSQVSLGWEPVIPLANESEVVGYKVFYRQEGHSNSQVIETQKLQAVVPLPDAGVYIIEV

--------------------------------------------------------------

>6208_6208_6_ARHGEF12-CNTN5_ARHGEF12_chr11_120278532_ENST00000397843_CNTN5_chr11_99786786_ENST00000279463_length(amino acids)=956AA_BP=46
MSGTQSTITDRFPLKKPIRHGSILNRESPTDKKQKVERIASHDFDPTDLGNFSGRTRSAVSVREGQGVVLMCSPPPHSPEIIYSWVFNEF
PSFVAEDSRRFISQETGNLYISKVQTSDVGSYICLVKNTVTNARVLSPPTPLTLRNDGVMGEYEPKIEVHFPFTVTAAKGTTVKMECFAL
GNPVPTITWMKVNGYIPSKARLRKSQAVLEIPNVQLDDAGIYECRAENSRGKNSFRGQLQVYTYPHWVEKLNDTQLDSGSPLRWECKATG
KPRPTYRWLKNGVPLSPQSRVEMVNGVLMIHNVNQSDAGMYQCLAENKYGAIYASAELKILASAPTFALNQLKKTIIVTKDQEVVIECKP
QGSPKPTISWKKGDRAVRENKRIAILPDGSLRILNASKSDEGKYVCRGENVFGSAEIIASLSVKEPTRIELTPKRTELTVGESIVLNCKA
IHDASLDVTFYWTLKGQPIDFEEEGGHFESIRAQASSADLMIRNILLMHAGRYGCRVQTTADSVSDEAELLVRGPPGPPGIVIVEEITES
TATLSWSPAADNHSPISSYNLQARSPFSLGWQTVKTVPEIITGDMESAMAVDLNPWVEYEFRVVATNPIGTGDPSTPSRMIRTNEAVPKT
APTNVSGRSGRRHELVIAWEPVSEEFQNGEGFGYIVAFRPNGTRGWKEKMVTSSEASKFIYRDESVPPLTPFEVKVGVYNNKGDGPFSQI
VVICSAEGEPSAAPTDVKATSVSVSEILVAWKHIKESLGRPQGFEVGYWKDMEQEDTAETVKTRGNESFVILTGLEGNTLYHFTVRAYNG
AGYGPPSSEVSATTKKSPPSQAPSNLRWEQQGSQVSLGWEPVIPLANESEVVGYKVFYRQEGHSNSQVIETQKLQAVVPLPDAGVYIIEV

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>6208_6208_7_ARHGEF12-CNTN5_ARHGEF12_chr11_120278532_ENST00000397843_CNTN5_chr11_99786786_ENST00000418526_length(amino acids)=955AA_BP=46
MSGTQSTITDRFPLKKPIRHGSILNRESPTDKKQKVERIASHDFDPTDLGNFSGRTRSAVSVREGQGVVLMCSPPPHSPEIIYSWVFNEF
PSFVAEDSRRFISQETGNLYISKVQTSDVGSYICLVKNTVTNARVLSPPTPLTLRNDGVMGEYEPKIEVHFPFTVTAAKGTTVKMECFAL
GNPVPTITWMKVNGYIPSKARLRKSQAVLEIPNVQLDDAGIYECRAENSRGKNSFRGQLQVYTYPHWVEKLNDTQLDSGSPLRWECKATG
KPRPTYRWLKNGVPLSPQSRVEMVNGVLMIHNVNQSDAGMYQCLAENKYGAIYASAELKILASAPTFALNQLKKTIIVTKDQEVVIECKP
QGSPKPTISWKKGDRAVRENKRIAILPDGSLRILNASKSDEGKYVCRGENVFGSAEIIASLSVKEPTRIELTPKRTELTVGESIVLNCKA
IHDASLDVTFYWTLKGQPIDFEEEGGHFESIRAQASSADLMIRNILLMHAGRYGCRVQTTADSVSDEAELLVRGPPGPPGIVIVEEITES
TATLSWSPAADNHSPISSYNLQARSPFSLGWQTVKTVPEIITGDMESAMAVDLNPWVEYEFRVVATNPIGTGDPSTPSRMIRTNEAVPKT
APTNVSGRSGRRHELVIAWEPVSEEFQNGEGFGYIVAFRPNGTRGWKEKMVTSSEASKFIYRDESVPPLTPFEVKVGVYNNKGDGPFSQI
VVICSAEGEPSAAPTDVKATSVSVSEILVAWKHIKESLGRPQGFEVGYWKDMEQEDTAETVKTRGNESFVILTGLEGNTLYHFTVRAYNG
AGYGPPSSEVSATTKKSPPSQAPSNLRWEQQGSQVSLGWEPVIPLANESEVVGYKVFYRQEGHSNSQVIETQKLQAVVPLPDAGVYIIEV

--------------------------------------------------------------

>6208_6208_8_ARHGEF12-CNTN5_ARHGEF12_chr11_120278532_ENST00000397843_CNTN5_chr11_99786786_ENST00000524871_length(amino acids)=955AA_BP=46
MSGTQSTITDRFPLKKPIRHGSILNRESPTDKKQKVERIASHDFDPTDLGNFSGRTRSAVSVREGQGVVLMCSPPPHSPEIIYSWVFNEF
PSFVAEDSRRFISQETGNLYISKVQTSDVGSYICLVKNTVTNARVLSPPTPLTLRNDGVMGEYEPKIEVHFPFTVTAAKGTTVKMECFAL
GNPVPTITWMKVNGYIPSKARLRKSQAVLEIPNVQLDDAGIYECRAENSRGKNSFRGQLQVYTYPHWVEKLNDTQLDSGSPLRWECKATG
KPRPTYRWLKNGVPLSPQSRVEMVNGVLMIHNVNQSDAGMYQCLAENKYGAIYASAELKILASAPTFALNQLKKTIIVTKDQEVVIECKP
QGSPKPTISWKKGDRAVRENKRIAILPDGSLRILNASKSDEGKYVCRGENVFGSAEIIASLSVKEPTRIELTPKRTELTVGESIVLNCKA
IHDASLDVTFYWTLKGQPIDFEEEGGHFESIRAQASSADLMIRNILLMHAGRYGCRVQTTADSVSDEAELLVRGPPGPPGIVIVEEITES
TATLSWSPAADNHSPISSYNLQARSPFSLGWQTVKTVPEIITGDMESAMAVDLNPWVEYEFRVVATNPIGTGDPSTPSRMIRTNEAVPKT
APTNVSGRSGRRHELVIAWEPVSEEFQNGEGFGYIVAFRPNGTRGWKEKMVTSSEASKFIYRDESVPPLTPFEVKVGVYNNKGDGPFSQI
VVICSAEGEPSAAPTDVKATSVSVSEILVAWKHIKESLGRPQGFEVGYWKDMEQEDTAETVKTRGNESFVILTGLEGNTLYHFTVRAYNG
AGYGPPSSEVSATTKKSPPSQAPSNLRWEQQGSQVSLGWEPVIPLANESEVVGYKVFYRQEGHSNSQVIETQKLQAVVPLPDAGVYIIEV

--------------------------------------------------------------

>6208_6208_9_ARHGEF12-CNTN5_ARHGEF12_chr11_120278532_ENST00000397843_CNTN5_chr11_99786786_ENST00000527185_length(amino acids)=766AA_BP=46
MSGTQSTITDRFPLKKPIRHGSILNRESPTDKKQKVERIASHDFDPTDLGNFSGRTRSAVSVREGQGVVLMCSPPPHSPEIIYSWVFNEF
PSFVAEDSRRFISQETGNLYISKVQTSDVGSYICLVKNTVTNARVLSPPTPLTLRNDGVMGEYEPKIEVHFPFTVTAAKGTTVKMECFAL
GNPVPTITWMKVNGYIPSKARLRKSQAVLEIPNVQLDDAGIYECRAENSRGKNSFRGQLQVYTYPHWVEKLNDTQLDSGSPLRWECKATG
KPRPTYRWLKNGVPLSPQSRVEMVNGVLMIHNVNQSDAGMYQCLAENKYGAIYASAELKILASAPTFALNQLKKTIIVTKDQEVVIECKP
QGSPKPTISWKKGDRAVRENKRIAILPDGSLRILNASKSDEGKYVCRGENVFGSAEIIASLSVKEPTRIELTPKRTELTVGESIVLNCKA
IHDASLDVTFYWTLKGQPIDFEEEGGHFESIRAQASSADLMIRNILLMHAGRYGCRVQTTADSVSDEAELLVRGPPGPPGIVIVEEITES
TATLSWSPAADNHSPISSYNLQARSPFSLGWQTVKTVPEIITGDMESAMAVDLNPWVEYEFRVVATNPIGTGDPSTPSRMIRTNEAVPKT
APTNVSGRSGRRHELVIAWEPVSEEFQNGEGFGYIVAFRPNGTRGWKEKMVTSSEASKFIYRDESVPPLTPFEVKVGVYNNKGDGPFSQI

--------------------------------------------------------------

>6208_6208_10_ARHGEF12-CNTN5_ARHGEF12_chr11_120278532_ENST00000397843_CNTN5_chr11_99786786_ENST00000528682_length(amino acids)=955AA_BP=46
MSGTQSTITDRFPLKKPIRHGSILNRESPTDKKQKVERIASHDFDPTDLGNFSGRTRSAVSVREGQGVVLMCSPPPHSPEIIYSWVFNEF
PSFVAEDSRRFISQETGNLYISKVQTSDVGSYICLVKNTVTNARVLSPPTPLTLRNDGVMGEYEPKIEVHFPFTVTAAKGTTVKMECFAL
GNPVPTITWMKVNGYIPSKARLRKSQAVLEIPNVQLDDAGIYECRAENSRGKNSFRGQLQVYTYPHWVEKLNDTQLDSGSPLRWECKATG
KPRPTYRWLKNGVPLSPQSRVEMVNGVLMIHNVNQSDAGMYQCLAENKYGAIYASAELKILASAPTFALNQLKKTIIVTKDQEVVIECKP
QGSPKPTISWKKGDRAVRENKRIAILPDGSLRILNASKSDEGKYVCRGENVFGSAEIIASLSVKEPTRIELTPKRTELTVGESIVLNCKA
IHDASLDVTFYWTLKGQPIDFEEEGGHFESIRAQASSADLMIRNILLMHAGRYGCRVQTTADSVSDEAELLVRGPPGPPGIVIVEEITES
TATLSWSPAADNHSPISSYNLQARSPFSLGWQTVKTVPEIITGDMESAMAVDLNPWVEYEFRVVATNPIGTGDPSTPSRMIRTNEAVPKT
APTNVSGRSGRRHELVIAWEPVSEEFQNGEGFGYIVAFRPNGTRGWKEKMVTSSEASKFIYRDESVPPLTPFEVKVGVYNNKGDGPFSQI
VVICSAEGEPSAAPTDVKATSVSVSEILVAWKHIKESLGRPQGFEVGYWKDMEQEDTAETVKTRGNESFVILTGLEGNTLYHFTVRAYNG
AGYGPPSSEVSATTKKSPPSQAPSNLRWEQQGSQVSLGWEPVIPLANESEVVGYKVFYRQEGHSNSQVIETQKLQAVVPLPDAGVYIIEV

--------------------------------------------------------------

>6208_6208_11_ARHGEF12-CNTN5_ARHGEF12_chr11_120280159_ENST00000397843_CNTN5_chr11_99786786_ENST00000279463_length(amino acids)=975AA_BP=66
MSGTQSTITDRFPLKKPIRHGSILNRESPTDKKQKVERIASHDFDPTDSSSKKTKSSSEESRSEIYDLGNFSGRTRSAVSVREGQGVVLM
CSPPPHSPEIIYSWVFNEFPSFVAEDSRRFISQETGNLYISKVQTSDVGSYICLVKNTVTNARVLSPPTPLTLRNDGVMGEYEPKIEVHF
PFTVTAAKGTTVKMECFALGNPVPTITWMKVNGYIPSKARLRKSQAVLEIPNVQLDDAGIYECRAENSRGKNSFRGQLQVYTYPHWVEKL
NDTQLDSGSPLRWECKATGKPRPTYRWLKNGVPLSPQSRVEMVNGVLMIHNVNQSDAGMYQCLAENKYGAIYASAELKILASAPTFALNQ
LKKTIIVTKDQEVVIECKPQGSPKPTISWKKGDRAVRENKRIAILPDGSLRILNASKSDEGKYVCRGENVFGSAEIIASLSVKEPTRIEL
TPKRTELTVGESIVLNCKAIHDASLDVTFYWTLKGQPIDFEEEGGHFESIRAQASSADLMIRNILLMHAGRYGCRVQTTADSVSDEAELL
VRGPPGPPGIVIVEEITESTATLSWSPAADNHSPISSYNLQARSPFSLGWQTVKTVPEIITGDMESAMAVDLNPWVEYEFRVVATNPIGT
GDPSTPSRMIRTNEAVPKTAPTNVSGRSGRRHELVIAWEPVSEEFQNGEGFGYIVAFRPNGTRGWKEKMVTSSEASKFIYRDESVPPLTP
FEVKVGVYNNKGDGPFSQIVVICSAEGEPSAAPTDVKATSVSVSEILVAWKHIKESLGRPQGFEVGYWKDMEQEDTAETVKTRGNESFVI
LTGLEGNTLYHFTVRAYNGAGYGPPSSEVSATTKKSPPSQAPSNLRWEQQGSQVSLGWEPVIPLANESEVVGYKVFYRQEGHSNSQVIET

--------------------------------------------------------------

>6208_6208_12_ARHGEF12-CNTN5_ARHGEF12_chr11_120280159_ENST00000397843_CNTN5_chr11_99786786_ENST00000418526_length(amino acids)=974AA_BP=66
MSGTQSTITDRFPLKKPIRHGSILNRESPTDKKQKVERIASHDFDPTDSSSKKTKSSSEESRSEIYDLGNFSGRTRSAVSVREGQGVVLM
CSPPPHSPEIIYSWVFNEFPSFVAEDSRRFISQETGNLYISKVQTSDVGSYICLVKNTVTNARVLSPPTPLTLRNDGVMGEYEPKIEVHF
PFTVTAAKGTTVKMECFALGNPVPTITWMKVNGYIPSKARLRKSQAVLEIPNVQLDDAGIYECRAENSRGKNSFRGQLQVYTYPHWVEKL
NDTQLDSGSPLRWECKATGKPRPTYRWLKNGVPLSPQSRVEMVNGVLMIHNVNQSDAGMYQCLAENKYGAIYASAELKILASAPTFALNQ
LKKTIIVTKDQEVVIECKPQGSPKPTISWKKGDRAVRENKRIAILPDGSLRILNASKSDEGKYVCRGENVFGSAEIIASLSVKEPTRIEL
TPKRTELTVGESIVLNCKAIHDASLDVTFYWTLKGQPIDFEEEGGHFESIRAQASSADLMIRNILLMHAGRYGCRVQTTADSVSDEAELL
VRGPPGPPGIVIVEEITESTATLSWSPAADNHSPISSYNLQARSPFSLGWQTVKTVPEIITGDMESAMAVDLNPWVEYEFRVVATNPIGT
GDPSTPSRMIRTNEAVPKTAPTNVSGRSGRRHELVIAWEPVSEEFQNGEGFGYIVAFRPNGTRGWKEKMVTSSEASKFIYRDESVPPLTP
FEVKVGVYNNKGDGPFSQIVVICSAEGEPSAAPTDVKATSVSVSEILVAWKHIKESLGRPQGFEVGYWKDMEQEDTAETVKTRGNESFVI
LTGLEGNTLYHFTVRAYNGAGYGPPSSEVSATTKKSPPSQAPSNLRWEQQGSQVSLGWEPVIPLANESEVVGYKVFYRQEGHSNSQVIET

--------------------------------------------------------------

>6208_6208_13_ARHGEF12-CNTN5_ARHGEF12_chr11_120280159_ENST00000397843_CNTN5_chr11_99786786_ENST00000524871_length(amino acids)=974AA_BP=66
MSGTQSTITDRFPLKKPIRHGSILNRESPTDKKQKVERIASHDFDPTDSSSKKTKSSSEESRSEIYDLGNFSGRTRSAVSVREGQGVVLM
CSPPPHSPEIIYSWVFNEFPSFVAEDSRRFISQETGNLYISKVQTSDVGSYICLVKNTVTNARVLSPPTPLTLRNDGVMGEYEPKIEVHF
PFTVTAAKGTTVKMECFALGNPVPTITWMKVNGYIPSKARLRKSQAVLEIPNVQLDDAGIYECRAENSRGKNSFRGQLQVYTYPHWVEKL
NDTQLDSGSPLRWECKATGKPRPTYRWLKNGVPLSPQSRVEMVNGVLMIHNVNQSDAGMYQCLAENKYGAIYASAELKILASAPTFALNQ
LKKTIIVTKDQEVVIECKPQGSPKPTISWKKGDRAVRENKRIAILPDGSLRILNASKSDEGKYVCRGENVFGSAEIIASLSVKEPTRIEL
TPKRTELTVGESIVLNCKAIHDASLDVTFYWTLKGQPIDFEEEGGHFESIRAQASSADLMIRNILLMHAGRYGCRVQTTADSVSDEAELL
VRGPPGPPGIVIVEEITESTATLSWSPAADNHSPISSYNLQARSPFSLGWQTVKTVPEIITGDMESAMAVDLNPWVEYEFRVVATNPIGT
GDPSTPSRMIRTNEAVPKTAPTNVSGRSGRRHELVIAWEPVSEEFQNGEGFGYIVAFRPNGTRGWKEKMVTSSEASKFIYRDESVPPLTP
FEVKVGVYNNKGDGPFSQIVVICSAEGEPSAAPTDVKATSVSVSEILVAWKHIKESLGRPQGFEVGYWKDMEQEDTAETVKTRGNESFVI
LTGLEGNTLYHFTVRAYNGAGYGPPSSEVSATTKKSPPSQAPSNLRWEQQGSQVSLGWEPVIPLANESEVVGYKVFYRQEGHSNSQVIET

--------------------------------------------------------------

>6208_6208_14_ARHGEF12-CNTN5_ARHGEF12_chr11_120280159_ENST00000397843_CNTN5_chr11_99786786_ENST00000527185_length(amino acids)=785AA_BP=66
MSGTQSTITDRFPLKKPIRHGSILNRESPTDKKQKVERIASHDFDPTDSSSKKTKSSSEESRSEIYDLGNFSGRTRSAVSVREGQGVVLM
CSPPPHSPEIIYSWVFNEFPSFVAEDSRRFISQETGNLYISKVQTSDVGSYICLVKNTVTNARVLSPPTPLTLRNDGVMGEYEPKIEVHF
PFTVTAAKGTTVKMECFALGNPVPTITWMKVNGYIPSKARLRKSQAVLEIPNVQLDDAGIYECRAENSRGKNSFRGQLQVYTYPHWVEKL
NDTQLDSGSPLRWECKATGKPRPTYRWLKNGVPLSPQSRVEMVNGVLMIHNVNQSDAGMYQCLAENKYGAIYASAELKILASAPTFALNQ
LKKTIIVTKDQEVVIECKPQGSPKPTISWKKGDRAVRENKRIAILPDGSLRILNASKSDEGKYVCRGENVFGSAEIIASLSVKEPTRIEL
TPKRTELTVGESIVLNCKAIHDASLDVTFYWTLKGQPIDFEEEGGHFESIRAQASSADLMIRNILLMHAGRYGCRVQTTADSVSDEAELL
VRGPPGPPGIVIVEEITESTATLSWSPAADNHSPISSYNLQARSPFSLGWQTVKTVPEIITGDMESAMAVDLNPWVEYEFRVVATNPIGT
GDPSTPSRMIRTNEAVPKTAPTNVSGRSGRRHELVIAWEPVSEEFQNGEGFGYIVAFRPNGTRGWKEKMVTSSEASKFIYRDESVPPLTP

--------------------------------------------------------------

>6208_6208_15_ARHGEF12-CNTN5_ARHGEF12_chr11_120280159_ENST00000397843_CNTN5_chr11_99786786_ENST00000528682_length(amino acids)=974AA_BP=66
MSGTQSTITDRFPLKKPIRHGSILNRESPTDKKQKVERIASHDFDPTDSSSKKTKSSSEESRSEIYDLGNFSGRTRSAVSVREGQGVVLM
CSPPPHSPEIIYSWVFNEFPSFVAEDSRRFISQETGNLYISKVQTSDVGSYICLVKNTVTNARVLSPPTPLTLRNDGVMGEYEPKIEVHF
PFTVTAAKGTTVKMECFALGNPVPTITWMKVNGYIPSKARLRKSQAVLEIPNVQLDDAGIYECRAENSRGKNSFRGQLQVYTYPHWVEKL
NDTQLDSGSPLRWECKATGKPRPTYRWLKNGVPLSPQSRVEMVNGVLMIHNVNQSDAGMYQCLAENKYGAIYASAELKILASAPTFALNQ
LKKTIIVTKDQEVVIECKPQGSPKPTISWKKGDRAVRENKRIAILPDGSLRILNASKSDEGKYVCRGENVFGSAEIIASLSVKEPTRIEL
TPKRTELTVGESIVLNCKAIHDASLDVTFYWTLKGQPIDFEEEGGHFESIRAQASSADLMIRNILLMHAGRYGCRVQTTADSVSDEAELL
VRGPPGPPGIVIVEEITESTATLSWSPAADNHSPISSYNLQARSPFSLGWQTVKTVPEIITGDMESAMAVDLNPWVEYEFRVVATNPIGT
GDPSTPSRMIRTNEAVPKTAPTNVSGRSGRRHELVIAWEPVSEEFQNGEGFGYIVAFRPNGTRGWKEKMVTSSEASKFIYRDESVPPLTP
FEVKVGVYNNKGDGPFSQIVVICSAEGEPSAAPTDVKATSVSVSEILVAWKHIKESLGRPQGFEVGYWKDMEQEDTAETVKTRGNESFVI
LTGLEGNTLYHFTVRAYNGAGYGPPSSEVSATTKKSPPSQAPSNLRWEQQGSQVSLGWEPVIPLANESEVVGYKVFYRQEGHSNSQVIET

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Top

Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr11:120278532/chr11:99786786)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ARHGEF12

Q9NZN5

CNTN5

O94779

FUNCTION: May play a role in the regulation of RhoA GTPase by guanine nucleotide-binding alpha-12 (GNA12) and alpha-13 (GNA13). Acts as guanine nucleotide exchange factor (GEF) for RhoA GTPase and may act as GTPase-activating protein (GAP) for GNA12 and GNA13. {ECO:0000269|PubMed:11094164}.FUNCTION: Contactins mediate cell surface interactions during nervous system development. Has some neurite outgrowth-promoting activity in the cerebral cortical neurons but not in hippocampal neurons. Probably involved in neuronal activity in the auditory system (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneCNTN5chr11:120278532chr11:99786786ENST00000279463323196_282192.333333333333341101.0DomainNote=Ig-like C2-type 2
TgeneCNTN5chr11:120278532chr11:99786786ENST00000279463323300_385192.333333333333341101.0DomainNote=Ig-like C2-type 3
TgeneCNTN5chr11:120278532chr11:99786786ENST00000279463323390_474192.333333333333341101.0DomainNote=Ig-like C2-type 4
TgeneCNTN5chr11:120278532chr11:99786786ENST00000279463323480_567192.333333333333341101.0DomainNote=Ig-like C2-type 5
TgeneCNTN5chr11:120278532chr11:99786786ENST00000279463323571_660192.333333333333341101.0DomainNote=Ig-like C2-type 6
TgeneCNTN5chr11:120278532chr11:99786786ENST00000279463323673_771192.333333333333341101.0DomainFibronectin type-III 1
TgeneCNTN5chr11:120278532chr11:99786786ENST00000279463323776_873192.333333333333341101.0DomainFibronectin type-III 2
TgeneCNTN5chr11:120278532chr11:99786786ENST00000279463323878_972192.333333333333341101.0DomainFibronectin type-III 3
TgeneCNTN5chr11:120278532chr11:99786786ENST00000279463323977_1067192.333333333333341101.0DomainFibronectin type-III 4
TgeneCNTN5chr11:120278532chr11:99786786ENST00000418526222196_282118.333333333333331027.0DomainNote=Ig-like C2-type 2
TgeneCNTN5chr11:120278532chr11:99786786ENST00000418526222300_385118.333333333333331027.0DomainNote=Ig-like C2-type 3
TgeneCNTN5chr11:120278532chr11:99786786ENST00000418526222390_474118.333333333333331027.0DomainNote=Ig-like C2-type 4
TgeneCNTN5chr11:120278532chr11:99786786ENST00000418526222480_567118.333333333333331027.0DomainNote=Ig-like C2-type 5
TgeneCNTN5chr11:120278532chr11:99786786ENST00000418526222571_660118.333333333333331027.0DomainNote=Ig-like C2-type 6
TgeneCNTN5chr11:120278532chr11:99786786ENST00000418526222673_771118.333333333333331027.0DomainFibronectin type-III 1
TgeneCNTN5chr11:120278532chr11:99786786ENST00000418526222776_873118.333333333333331027.0DomainFibronectin type-III 2
TgeneCNTN5chr11:120278532chr11:99786786ENST00000418526222878_972118.333333333333331027.0DomainFibronectin type-III 3
TgeneCNTN5chr11:120278532chr11:99786786ENST00000418526222977_1067118.333333333333331027.0DomainFibronectin type-III 4
TgeneCNTN5chr11:120278532chr11:99786786ENST00000524871525196_282192.333333333333341101.0DomainNote=Ig-like C2-type 2
TgeneCNTN5chr11:120278532chr11:99786786ENST00000524871525300_385192.333333333333341101.0DomainNote=Ig-like C2-type 3
TgeneCNTN5chr11:120278532chr11:99786786ENST00000524871525390_474192.333333333333341101.0DomainNote=Ig-like C2-type 4
TgeneCNTN5chr11:120278532chr11:99786786ENST00000524871525480_567192.333333333333341101.0DomainNote=Ig-like C2-type 5
TgeneCNTN5chr11:120278532chr11:99786786ENST00000524871525571_660192.333333333333341101.0DomainNote=Ig-like C2-type 6
TgeneCNTN5chr11:120278532chr11:99786786ENST00000524871525673_771192.333333333333341101.0DomainFibronectin type-III 1
TgeneCNTN5chr11:120278532chr11:99786786ENST00000524871525776_873192.333333333333341101.0DomainFibronectin type-III 2
TgeneCNTN5chr11:120278532chr11:99786786ENST00000524871525878_972192.333333333333341101.0DomainFibronectin type-III 3
TgeneCNTN5chr11:120278532chr11:99786786ENST00000524871525977_1067192.333333333333341101.0DomainFibronectin type-III 4
TgeneCNTN5chr11:120278532chr11:99786786ENST00000527185521196_282192.33333333333334912.0DomainNote=Ig-like C2-type 2
TgeneCNTN5chr11:120278532chr11:99786786ENST00000527185521300_385192.33333333333334912.0DomainNote=Ig-like C2-type 3
TgeneCNTN5chr11:120278532chr11:99786786ENST00000527185521390_474192.33333333333334912.0DomainNote=Ig-like C2-type 4
TgeneCNTN5chr11:120278532chr11:99786786ENST00000527185521480_567192.33333333333334912.0DomainNote=Ig-like C2-type 5
TgeneCNTN5chr11:120278532chr11:99786786ENST00000527185521571_660192.33333333333334912.0DomainNote=Ig-like C2-type 6
TgeneCNTN5chr11:120278532chr11:99786786ENST00000527185521673_771192.33333333333334912.0DomainFibronectin type-III 1
TgeneCNTN5chr11:120278532chr11:99786786ENST00000527185521776_873192.33333333333334912.0DomainFibronectin type-III 2
TgeneCNTN5chr11:120278532chr11:99786786ENST00000527185521878_972192.33333333333334912.0DomainFibronectin type-III 3
TgeneCNTN5chr11:120278532chr11:99786786ENST00000527185521977_1067192.33333333333334912.0DomainFibronectin type-III 4
TgeneCNTN5chr11:120278532chr11:99786786ENST00000528682424196_282192.333333333333341101.0DomainNote=Ig-like C2-type 2
TgeneCNTN5chr11:120278532chr11:99786786ENST00000528682424300_385192.333333333333341101.0DomainNote=Ig-like C2-type 3
TgeneCNTN5chr11:120278532chr11:99786786ENST00000528682424390_474192.333333333333341101.0DomainNote=Ig-like C2-type 4
TgeneCNTN5chr11:120278532chr11:99786786ENST00000528682424480_567192.333333333333341101.0DomainNote=Ig-like C2-type 5
TgeneCNTN5chr11:120278532chr11:99786786ENST00000528682424571_660192.333333333333341101.0DomainNote=Ig-like C2-type 6
TgeneCNTN5chr11:120278532chr11:99786786ENST00000528682424673_771192.333333333333341101.0DomainFibronectin type-III 1
TgeneCNTN5chr11:120278532chr11:99786786ENST00000528682424776_873192.333333333333341101.0DomainFibronectin type-III 2
TgeneCNTN5chr11:120278532chr11:99786786ENST00000528682424878_972192.333333333333341101.0DomainFibronectin type-III 3
TgeneCNTN5chr11:120278532chr11:99786786ENST00000528682424977_1067192.333333333333341101.0DomainFibronectin type-III 4
TgeneCNTN5chr11:120280159chr11:99786786ENST00000279463323196_282192.333333333333341101.0DomainNote=Ig-like C2-type 2
TgeneCNTN5chr11:120280159chr11:99786786ENST00000279463323300_385192.333333333333341101.0DomainNote=Ig-like C2-type 3
TgeneCNTN5chr11:120280159chr11:99786786ENST00000279463323390_474192.333333333333341101.0DomainNote=Ig-like C2-type 4
TgeneCNTN5chr11:120280159chr11:99786786ENST00000279463323480_567192.333333333333341101.0DomainNote=Ig-like C2-type 5
TgeneCNTN5chr11:120280159chr11:99786786ENST00000279463323571_660192.333333333333341101.0DomainNote=Ig-like C2-type 6
TgeneCNTN5chr11:120280159chr11:99786786ENST00000279463323673_771192.333333333333341101.0DomainFibronectin type-III 1
TgeneCNTN5chr11:120280159chr11:99786786ENST00000279463323776_873192.333333333333341101.0DomainFibronectin type-III 2
TgeneCNTN5chr11:120280159chr11:99786786ENST00000279463323878_972192.333333333333341101.0DomainFibronectin type-III 3
TgeneCNTN5chr11:120280159chr11:99786786ENST00000279463323977_1067192.333333333333341101.0DomainFibronectin type-III 4
TgeneCNTN5chr11:120280159chr11:99786786ENST00000418526222196_282118.333333333333331027.0DomainNote=Ig-like C2-type 2
TgeneCNTN5chr11:120280159chr11:99786786ENST00000418526222300_385118.333333333333331027.0DomainNote=Ig-like C2-type 3
TgeneCNTN5chr11:120280159chr11:99786786ENST00000418526222390_474118.333333333333331027.0DomainNote=Ig-like C2-type 4
TgeneCNTN5chr11:120280159chr11:99786786ENST00000418526222480_567118.333333333333331027.0DomainNote=Ig-like C2-type 5
TgeneCNTN5chr11:120280159chr11:99786786ENST00000418526222571_660118.333333333333331027.0DomainNote=Ig-like C2-type 6
TgeneCNTN5chr11:120280159chr11:99786786ENST00000418526222673_771118.333333333333331027.0DomainFibronectin type-III 1
TgeneCNTN5chr11:120280159chr11:99786786ENST00000418526222776_873118.333333333333331027.0DomainFibronectin type-III 2
TgeneCNTN5chr11:120280159chr11:99786786ENST00000418526222878_972118.333333333333331027.0DomainFibronectin type-III 3
TgeneCNTN5chr11:120280159chr11:99786786ENST00000418526222977_1067118.333333333333331027.0DomainFibronectin type-III 4
TgeneCNTN5chr11:120280159chr11:99786786ENST00000524871525196_282192.333333333333341101.0DomainNote=Ig-like C2-type 2
TgeneCNTN5chr11:120280159chr11:99786786ENST00000524871525300_385192.333333333333341101.0DomainNote=Ig-like C2-type 3
TgeneCNTN5chr11:120280159chr11:99786786ENST00000524871525390_474192.333333333333341101.0DomainNote=Ig-like C2-type 4
TgeneCNTN5chr11:120280159chr11:99786786ENST00000524871525480_567192.333333333333341101.0DomainNote=Ig-like C2-type 5
TgeneCNTN5chr11:120280159chr11:99786786ENST00000524871525571_660192.333333333333341101.0DomainNote=Ig-like C2-type 6
TgeneCNTN5chr11:120280159chr11:99786786ENST00000524871525673_771192.333333333333341101.0DomainFibronectin type-III 1
TgeneCNTN5chr11:120280159chr11:99786786ENST00000524871525776_873192.333333333333341101.0DomainFibronectin type-III 2
TgeneCNTN5chr11:120280159chr11:99786786ENST00000524871525878_972192.333333333333341101.0DomainFibronectin type-III 3
TgeneCNTN5chr11:120280159chr11:99786786ENST00000524871525977_1067192.333333333333341101.0DomainFibronectin type-III 4
TgeneCNTN5chr11:120280159chr11:99786786ENST00000527185521196_282192.33333333333334912.0DomainNote=Ig-like C2-type 2
TgeneCNTN5chr11:120280159chr11:99786786ENST00000527185521300_385192.33333333333334912.0DomainNote=Ig-like C2-type 3
TgeneCNTN5chr11:120280159chr11:99786786ENST00000527185521390_474192.33333333333334912.0DomainNote=Ig-like C2-type 4
TgeneCNTN5chr11:120280159chr11:99786786ENST00000527185521480_567192.33333333333334912.0DomainNote=Ig-like C2-type 5
TgeneCNTN5chr11:120280159chr11:99786786ENST00000527185521571_660192.33333333333334912.0DomainNote=Ig-like C2-type 6
TgeneCNTN5chr11:120280159chr11:99786786ENST00000527185521673_771192.33333333333334912.0DomainFibronectin type-III 1
TgeneCNTN5chr11:120280159chr11:99786786ENST00000527185521776_873192.33333333333334912.0DomainFibronectin type-III 2
TgeneCNTN5chr11:120280159chr11:99786786ENST00000527185521878_972192.33333333333334912.0DomainFibronectin type-III 3
TgeneCNTN5chr11:120280159chr11:99786786ENST00000527185521977_1067192.33333333333334912.0DomainFibronectin type-III 4
TgeneCNTN5chr11:120280159chr11:99786786ENST00000528682424196_282192.333333333333341101.0DomainNote=Ig-like C2-type 2
TgeneCNTN5chr11:120280159chr11:99786786ENST00000528682424300_385192.333333333333341101.0DomainNote=Ig-like C2-type 3
TgeneCNTN5chr11:120280159chr11:99786786ENST00000528682424390_474192.333333333333341101.0DomainNote=Ig-like C2-type 4
TgeneCNTN5chr11:120280159chr11:99786786ENST00000528682424480_567192.333333333333341101.0DomainNote=Ig-like C2-type 5
TgeneCNTN5chr11:120280159chr11:99786786ENST00000528682424571_660192.333333333333341101.0DomainNote=Ig-like C2-type 6
TgeneCNTN5chr11:120280159chr11:99786786ENST00000528682424673_771192.333333333333341101.0DomainFibronectin type-III 1
TgeneCNTN5chr11:120280159chr11:99786786ENST00000528682424776_873192.333333333333341101.0DomainFibronectin type-III 2
TgeneCNTN5chr11:120280159chr11:99786786ENST00000528682424878_972192.333333333333341101.0DomainFibronectin type-III 3
TgeneCNTN5chr11:120280159chr11:99786786ENST00000528682424977_1067192.333333333333341101.0DomainFibronectin type-III 4

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneARHGEF12chr11:120278532chr11:99786786ENST00000356641+340194_26247.3333333333333361526.0Coiled coilOntology_term=ECO:0000255
HgeneARHGEF12chr11:120278532chr11:99786786ENST00000397843+341194_26247.3333333333333361545.0Coiled coilOntology_term=ECO:0000255
HgeneARHGEF12chr11:120280159chr11:99786786ENST00000356641-140194_26201526.0Coiled coilOntology_term=ECO:0000255
HgeneARHGEF12chr11:120280159chr11:99786786ENST00000397843-441194_26266.333333333333331545.0Coiled coilOntology_term=ECO:0000255
HgeneARHGEF12chr11:120278532chr11:99786786ENST00000356641+3401019_113247.3333333333333361526.0DomainPH
HgeneARHGEF12chr11:120278532chr11:99786786ENST00000356641+340367_55847.3333333333333361526.0DomainNote=RGSL
HgeneARHGEF12chr11:120278532chr11:99786786ENST00000356641+34072_15147.3333333333333361526.0DomainPDZ
HgeneARHGEF12chr11:120278532chr11:99786786ENST00000356641+340787_97747.3333333333333361526.0DomainDH
HgeneARHGEF12chr11:120278532chr11:99786786ENST00000397843+3411019_113247.3333333333333361545.0DomainPH
HgeneARHGEF12chr11:120278532chr11:99786786ENST00000397843+341367_55847.3333333333333361545.0DomainNote=RGSL
HgeneARHGEF12chr11:120278532chr11:99786786ENST00000397843+34172_15147.3333333333333361545.0DomainPDZ
HgeneARHGEF12chr11:120278532chr11:99786786ENST00000397843+341787_97747.3333333333333361545.0DomainDH
HgeneARHGEF12chr11:120280159chr11:99786786ENST00000356641-1401019_113201526.0DomainPH
HgeneARHGEF12chr11:120280159chr11:99786786ENST00000356641-140367_55801526.0DomainNote=RGSL
HgeneARHGEF12chr11:120280159chr11:99786786ENST00000356641-14072_15101526.0DomainPDZ
HgeneARHGEF12chr11:120280159chr11:99786786ENST00000356641-140787_97701526.0DomainDH
HgeneARHGEF12chr11:120280159chr11:99786786ENST00000397843-4411019_113266.333333333333331545.0DomainPH
HgeneARHGEF12chr11:120280159chr11:99786786ENST00000397843-441367_55866.333333333333331545.0DomainNote=RGSL
HgeneARHGEF12chr11:120280159chr11:99786786ENST00000397843-44172_15166.333333333333331545.0DomainPDZ
HgeneARHGEF12chr11:120280159chr11:99786786ENST00000397843-441787_97766.333333333333331545.0DomainDH
TgeneCNTN5chr11:120278532chr11:99786786ENST0000027946332399_190192.333333333333341101.0DomainNote=Ig-like C2-type 1
TgeneCNTN5chr11:120278532chr11:99786786ENST0000041852622299_190118.333333333333331027.0DomainNote=Ig-like C2-type 1
TgeneCNTN5chr11:120278532chr11:99786786ENST0000052487152599_190192.333333333333341101.0DomainNote=Ig-like C2-type 1
TgeneCNTN5chr11:120278532chr11:99786786ENST0000052718552199_190192.33333333333334912.0DomainNote=Ig-like C2-type 1
TgeneCNTN5chr11:120278532chr11:99786786ENST0000052868242499_190192.333333333333341101.0DomainNote=Ig-like C2-type 1
TgeneCNTN5chr11:120280159chr11:99786786ENST0000027946332399_190192.333333333333341101.0DomainNote=Ig-like C2-type 1
TgeneCNTN5chr11:120280159chr11:99786786ENST0000041852622299_190118.333333333333331027.0DomainNote=Ig-like C2-type 1
TgeneCNTN5chr11:120280159chr11:99786786ENST0000052487152599_190192.333333333333341101.0DomainNote=Ig-like C2-type 1
TgeneCNTN5chr11:120280159chr11:99786786ENST0000052718552199_190192.33333333333334912.0DomainNote=Ig-like C2-type 1
TgeneCNTN5chr11:120280159chr11:99786786ENST0000052868242499_190192.333333333333341101.0DomainNote=Ig-like C2-type 1


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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
ARHGEF12all structure
CNTN5


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to ARHGEF12-CNTN5


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to ARHGEF12-CNTN5


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneARHGEF12C0043094Weight Gain1CTD_human