UTHEALTH HOME    ABOUT SBMI    A-Z    WEBMAIL    INSIDE THE UNIVERSITY
FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact

Terms of Use
Center for Computational Systems Medicine level1
leaf

Fusion Gene Summary

leaf

Fusion Gene Sample Information

leaf

Fusion ORF Analysis

leaf

Fusion Amino Acid Sequences

leaf

Fusion Protein Functional Features

leaf

Fusion Protein-Protein Interaction

leaf

Related drugs with this fusion protein

leaf

Related disease with this fusion protein

Fusion Protein:PAX5-ZNF521

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: PAX5-ZNF521
FusionPDB ID: 62961
FusionGDB2.0 ID: 62961
HgeneTgene
Gene symbol

PAX5

ZNF521

Gene ID

5079

25925

Gene namepaired box 5zinc finger protein 521
SynonymsALL3|BSAPEHZF|Evi3
Cytomap

9p13.2

18q11.2

Type of geneprotein-codingprotein-coding
Descriptionpaired box protein Pax-5B-cell lineage specific activatorpaired box homeotic gene 5paired domain gene 5transcription factor PAX 5zinc finger protein 521LYST-interacting protein 3early hematopoietic zinc finger protein
Modification date2020031320200313
UniProtAcc

Q02548

.
Ensembl transtripts involved in fusion geneENST idsENST00000358127, ENST00000377847, 
ENST00000377852, ENST00000377853, 
ENST00000414447, ENST00000446742, 
ENST00000520281, ENST00000522003, 
ENST00000523145, ENST00000520154, 
ENST00000523241, 		ENST00000538137, 
ENST00000579111, ENST00000584787, 
ENST00000361524, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score15 X 15 X 7=157513 X 10 X 9=1170
# samples 1015
** MAII scorelog2(10/1575*10)=-3.97727992349992
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(15/1170*10)=-2.96347412397489
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: PAX5 [Title/Abstract] AND ZNF521 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)PAX5(36923352)-ZNF521(22807664), # samples:1
Anticipated loss of major functional domain due to fusion event.PAX5-ZNF521 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
PAX5-ZNF521 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
PAX5-ZNF521 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
PAX5-ZNF521 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
PAX5-ZNF521 seems lost the major protein functional domain in Hgene partner, which is a CGC due to the frame-shifted ORF.
PAX5-ZNF521 seems lost the major protein functional domain in Hgene partner, which is a transcription factor due to the frame-shifted ORF.
PAX5-ZNF521 seems lost the major protein functional domain in Hgene partner, which is a tumor suppressor due to the frame-shifted ORF.
PAX5-ZNF521 seems lost the major protein functional domain in Tgene partner, which is a CGC due to the frame-shifted ORF.
PAX5-ZNF521 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
PAX5-ZNF521 seems lost the major protein functional domain in Tgene partner, which is a transcription factor due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across PAX5 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across ZNF521 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


Top

Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS5.0N/ADQ845345PAX5chr9

36923352

-ZNF521chr18

22807664

-


Top

Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000358127PAX5chr936923352-ENST00000361524ZNF521chr1822807664-54879857547001541
ENST00000377852PAX5chr936923352-ENST00000361524ZNF521chr1822807664-54229201046351541
ENST00000377853PAX5chr936923352-ENST00000361524ZNF521chr1822807664-54229201046351541
ENST00000520281PAX5chr936923352-ENST00000361524ZNF521chr1822807664-5283781044961498
ENST00000414447PAX5chr936923352-ENST00000361524ZNF521chr1822807664-5283781044961498
ENST00000446742PAX5chr936923352-ENST00000361524ZNF521chr1822807664-5214712044271475
ENST00000377847PAX5chr936923352-ENST00000361524ZNF521chr1822807664-5412910046251541

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000358127ENST00000361524PAX5chr936923352-ZNF521chr1822807664-0.0011666590.99883336
ENST00000377852ENST00000361524PAX5chr936923352-ZNF521chr1822807664-0.0012177470.9987822
ENST00000377853ENST00000361524PAX5chr936923352-ZNF521chr1822807664-0.0012177470.9987822
ENST00000520281ENST00000361524PAX5chr936923352-ZNF521chr1822807664-0.0011427910.99885726
ENST00000414447ENST00000361524PAX5chr936923352-ZNF521chr1822807664-0.0011427910.99885726
ENST00000446742ENST00000361524PAX5chr936923352-ZNF521chr1822807664-0.0013146720.9986853
ENST00000377847ENST00000361524PAX5chr936923352-ZNF521chr1822807664-0.001229190.9987708

Top

Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>62961_62961_1_PAX5-ZNF521_PAX5_chr9_36923352_ENST00000358127_ZNF521_chr18_22807664_ENST00000361524_length(amino acids)=1541AA_BP=301
MDLEKNYPTPRTSRTGHGGVNQLGGVFVNGRPLPDVVRQRIVELAHQGVRPCDISRQLRVSHGCVSKILGRYYETGSIKPGVIGGSKPKV
ATPKVVEKIAEYKRQNPTMFAWEIRDRLLAERVCDNDTVPSVSSINRIIRTKVQQPPNQPVPASSHSIVSTGSVTQVSSVSTDSAGSSYS
ISGILGITSPSADTNKRKRDEGIQESPVPNGHSLPGRDFLRKQMRGDLFTQQQLEVLDRVFERQHYSDIFTTTEPIKPEQTTEYSAMASL
AGGLDDMKANLASPTPADIGSSVPGPQSYPIVTDGVDVEDDPTCSWPASSPSSKDQTSPSHGEGCDFGEEEGGPGLPYPCQFCDKSFSRL
SYLKHHEQSHSDKLPFKCTYCSRLFKHKRSRDRHIKLHTGDKKYHCSECDAAFSRSDHLKIHLKTHTSNKPYKCAICRRGFLSSSSLHGH
MQVHERNKDGSQSGSRMEDWKMKDTQKCSQCEEGFDFPEDLQKHIAECHPECSPNEDRAALQCVYCHELFVEETSLMNHMEQVHSGEKKN
SCSICSESFHTVEELYSHMDSHQQPESCNHSNSPSLVTVGYTSVSSTTPDSNLSVDSSTMVEAAPPIPKSRGRKRAAQQTPDMTGPSSKQ
AKVTYSCIYCNKQLFSSLAVLQIHLKTMHLDKPEQAHICQYCLEVLPSLYNLNEHLKQVHEAQDPGLIVSAMPAIVYQCNFCSEVVNDLN
TLQEHIRCSHGFANPAAKDSNAFFCPHCYMGFLTDSSLEEHIRQVHCDLSGSRFGSPVLGTPKEPVVEVYSCSYCTNSPIFNSVLKLNKH
IKENHKNIPLALNYIHNGKKSRALSPLSPVAIEQTSLKMMQAVGGAPARPTGEYICNQCGAKYTSLDSFQTHLKTHLDTVLPKLTCPQCN
KEFPNQESLLKHVTIHFMITSTYYICESCDKQFTSVDDLQKHLLDMHTFVFFRCTLCQEVFDSKVSIQLHLAVKHSNEKKVYRCTSCNWD
FRNETDLQLHVKHNHLENQGKVHKCIFCGESFGTEVELQCHITTHSKKYNCKFCSKAFHAIILLEKHLREKHCVFETKTPNCGTNGASEQ
VQKEEVELQTLLTNSQESHNSHDGSEEDVDTSEPMYGCDICGAAYTMETLLQNHQLRDHNIRPGESAIVKKKAELIKGNYKCNVCSRTFF
SENGLREHMQTHLGPVKHYMCPICGERFPSLLTLTEHKVTHSKSLDTGNCRICKMPLQSEEEFLEHCQMHPDLRNSLTGFRCVVCMQTVT
STLELKIHGTFHMQKTGNGSAVQTTGRGQHVQKLYKCASCLKEFRSKQDLVKLDINGLPYGLCAGCVNLSKSASPGINVPPGTNRPGLGQ
NENLSAIEGKGKVGGLKTRCSSCNVKFESESELQNHIQTIHRELVPDSNSTQLKTPQVSPMPRISPSQSDEKKTYQCIKCQMVFYNEWDI
QVHVANHMIDEGLNHECKLCSQTFDSPAKLQCHLIEHSFEGMGGTFKCPVCFTVFVQANKLQQHIFSAHGQEDKIYDCTQCPQKFFFQTE

--------------------------------------------------------------

>62961_62961_2_PAX5-ZNF521_PAX5_chr9_36923352_ENST00000377847_ZNF521_chr18_22807664_ENST00000361524_length(amino acids)=1541AA_BP=301
MDLEKNYPTPRTSRTGHGGVNQLGGVFVNGRPLPDVVRQRIVELAHQGVRPCDISRQLRVSHGCVSKILGRYYETGSIKPGVIGGSKPKV
ATPKVVEKIAEYKRQNPTMFAWEIRDRLLAERVCDNDTVPSVSSINRIIRTKVQQPPNQPVPASSHSIVSTGSVTQVSSVSTDSAGSSYS
ISGILGITSPSADTNKRKRDEGIQESPVPNGHSLPGRDFLRKQMRGDLFTQQQLEVLDRVFERQHYSDIFTTTEPIKPEQTTEYSAMASL
AGGLDDMKANLASPTPADIGSSVPGPQSYPIVTDGVDVEDDPTCSWPASSPSSKDQTSPSHGEGCDFGEEEGGPGLPYPCQFCDKSFSRL
SYLKHHEQSHSDKLPFKCTYCSRLFKHKRSRDRHIKLHTGDKKYHCSECDAAFSRSDHLKIHLKTHTSNKPYKCAICRRGFLSSSSLHGH
MQVHERNKDGSQSGSRMEDWKMKDTQKCSQCEEGFDFPEDLQKHIAECHPECSPNEDRAALQCVYCHELFVEETSLMNHMEQVHSGEKKN
SCSICSESFHTVEELYSHMDSHQQPESCNHSNSPSLVTVGYTSVSSTTPDSNLSVDSSTMVEAAPPIPKSRGRKRAAQQTPDMTGPSSKQ
AKVTYSCIYCNKQLFSSLAVLQIHLKTMHLDKPEQAHICQYCLEVLPSLYNLNEHLKQVHEAQDPGLIVSAMPAIVYQCNFCSEVVNDLN
TLQEHIRCSHGFANPAAKDSNAFFCPHCYMGFLTDSSLEEHIRQVHCDLSGSRFGSPVLGTPKEPVVEVYSCSYCTNSPIFNSVLKLNKH
IKENHKNIPLALNYIHNGKKSRALSPLSPVAIEQTSLKMMQAVGGAPARPTGEYICNQCGAKYTSLDSFQTHLKTHLDTVLPKLTCPQCN
KEFPNQESLLKHVTIHFMITSTYYICESCDKQFTSVDDLQKHLLDMHTFVFFRCTLCQEVFDSKVSIQLHLAVKHSNEKKVYRCTSCNWD
FRNETDLQLHVKHNHLENQGKVHKCIFCGESFGTEVELQCHITTHSKKYNCKFCSKAFHAIILLEKHLREKHCVFETKTPNCGTNGASEQ
VQKEEVELQTLLTNSQESHNSHDGSEEDVDTSEPMYGCDICGAAYTMETLLQNHQLRDHNIRPGESAIVKKKAELIKGNYKCNVCSRTFF
SENGLREHMQTHLGPVKHYMCPICGERFPSLLTLTEHKVTHSKSLDTGNCRICKMPLQSEEEFLEHCQMHPDLRNSLTGFRCVVCMQTVT
STLELKIHGTFHMQKTGNGSAVQTTGRGQHVQKLYKCASCLKEFRSKQDLVKLDINGLPYGLCAGCVNLSKSASPGINVPPGTNRPGLGQ
NENLSAIEGKGKVGGLKTRCSSCNVKFESESELQNHIQTIHRELVPDSNSTQLKTPQVSPMPRISPSQSDEKKTYQCIKCQMVFYNEWDI
QVHVANHMIDEGLNHECKLCSQTFDSPAKLQCHLIEHSFEGMGGTFKCPVCFTVFVQANKLQQHIFSAHGQEDKIYDCTQCPQKFFFQTE

--------------------------------------------------------------

>62961_62961_3_PAX5-ZNF521_PAX5_chr9_36923352_ENST00000377852_ZNF521_chr18_22807664_ENST00000361524_length(amino acids)=1541AA_BP=301
MDLEKNYPTPRTSRTGHGGVNQLGGVFVNGRPLPDVVRQRIVELAHQGVRPCDISRQLRVSHGCVSKILGRYYETGSIKPGVIGGSKPKV
ATPKVVEKIAEYKRQNPTMFAWEIRDRLLAERVCDNDTVPSVSSINRIIRTKVQQPPNQPVPASSHSIVSTGSVTQVSSVSTDSAGSSYS
ISGILGITSPSADTNKRKRDEGIQESPVPNGHSLPGRDFLRKQMRGDLFTQQQLEVLDRVFERQHYSDIFTTTEPIKPEQTTEYSAMASL
AGGLDDMKANLASPTPADIGSSVPGPQSYPIVTDGVDVEDDPTCSWPASSPSSKDQTSPSHGEGCDFGEEEGGPGLPYPCQFCDKSFSRL
SYLKHHEQSHSDKLPFKCTYCSRLFKHKRSRDRHIKLHTGDKKYHCSECDAAFSRSDHLKIHLKTHTSNKPYKCAICRRGFLSSSSLHGH
MQVHERNKDGSQSGSRMEDWKMKDTQKCSQCEEGFDFPEDLQKHIAECHPECSPNEDRAALQCVYCHELFVEETSLMNHMEQVHSGEKKN
SCSICSESFHTVEELYSHMDSHQQPESCNHSNSPSLVTVGYTSVSSTTPDSNLSVDSSTMVEAAPPIPKSRGRKRAAQQTPDMTGPSSKQ
AKVTYSCIYCNKQLFSSLAVLQIHLKTMHLDKPEQAHICQYCLEVLPSLYNLNEHLKQVHEAQDPGLIVSAMPAIVYQCNFCSEVVNDLN
TLQEHIRCSHGFANPAAKDSNAFFCPHCYMGFLTDSSLEEHIRQVHCDLSGSRFGSPVLGTPKEPVVEVYSCSYCTNSPIFNSVLKLNKH
IKENHKNIPLALNYIHNGKKSRALSPLSPVAIEQTSLKMMQAVGGAPARPTGEYICNQCGAKYTSLDSFQTHLKTHLDTVLPKLTCPQCN
KEFPNQESLLKHVTIHFMITSTYYICESCDKQFTSVDDLQKHLLDMHTFVFFRCTLCQEVFDSKVSIQLHLAVKHSNEKKVYRCTSCNWD
FRNETDLQLHVKHNHLENQGKVHKCIFCGESFGTEVELQCHITTHSKKYNCKFCSKAFHAIILLEKHLREKHCVFETKTPNCGTNGASEQ
VQKEEVELQTLLTNSQESHNSHDGSEEDVDTSEPMYGCDICGAAYTMETLLQNHQLRDHNIRPGESAIVKKKAELIKGNYKCNVCSRTFF
SENGLREHMQTHLGPVKHYMCPICGERFPSLLTLTEHKVTHSKSLDTGNCRICKMPLQSEEEFLEHCQMHPDLRNSLTGFRCVVCMQTVT
STLELKIHGTFHMQKTGNGSAVQTTGRGQHVQKLYKCASCLKEFRSKQDLVKLDINGLPYGLCAGCVNLSKSASPGINVPPGTNRPGLGQ
NENLSAIEGKGKVGGLKTRCSSCNVKFESESELQNHIQTIHRELVPDSNSTQLKTPQVSPMPRISPSQSDEKKTYQCIKCQMVFYNEWDI
QVHVANHMIDEGLNHECKLCSQTFDSPAKLQCHLIEHSFEGMGGTFKCPVCFTVFVQANKLQQHIFSAHGQEDKIYDCTQCPQKFFFQTE

--------------------------------------------------------------

>62961_62961_4_PAX5-ZNF521_PAX5_chr9_36923352_ENST00000377853_ZNF521_chr18_22807664_ENST00000361524_length(amino acids)=1541AA_BP=301
MDLEKNYPTPRTSRTGHGGVNQLGGVFVNGRPLPDVVRQRIVELAHQGVRPCDISRQLRVSHGCVSKILGRYYETGSIKPGVIGGSKPKV
ATPKVVEKIAEYKRQNPTMFAWEIRDRLLAERVCDNDTVPSVSSINRIIRTKVQQPPNQPVPASSHSIVSTGSVTQVSSVSTDSAGSSYS
ISGILGITSPSADTNKRKRDEGIQESPVPNGHSLPGRDFLRKQMRGDLFTQQQLEVLDRVFERQHYSDIFTTTEPIKPEQTTEYSAMASL
AGGLDDMKANLASPTPADIGSSVPGPQSYPIVTDGVDVEDDPTCSWPASSPSSKDQTSPSHGEGCDFGEEEGGPGLPYPCQFCDKSFSRL
SYLKHHEQSHSDKLPFKCTYCSRLFKHKRSRDRHIKLHTGDKKYHCSECDAAFSRSDHLKIHLKTHTSNKPYKCAICRRGFLSSSSLHGH
MQVHERNKDGSQSGSRMEDWKMKDTQKCSQCEEGFDFPEDLQKHIAECHPECSPNEDRAALQCVYCHELFVEETSLMNHMEQVHSGEKKN
SCSICSESFHTVEELYSHMDSHQQPESCNHSNSPSLVTVGYTSVSSTTPDSNLSVDSSTMVEAAPPIPKSRGRKRAAQQTPDMTGPSSKQ
AKVTYSCIYCNKQLFSSLAVLQIHLKTMHLDKPEQAHICQYCLEVLPSLYNLNEHLKQVHEAQDPGLIVSAMPAIVYQCNFCSEVVNDLN
TLQEHIRCSHGFANPAAKDSNAFFCPHCYMGFLTDSSLEEHIRQVHCDLSGSRFGSPVLGTPKEPVVEVYSCSYCTNSPIFNSVLKLNKH
IKENHKNIPLALNYIHNGKKSRALSPLSPVAIEQTSLKMMQAVGGAPARPTGEYICNQCGAKYTSLDSFQTHLKTHLDTVLPKLTCPQCN
KEFPNQESLLKHVTIHFMITSTYYICESCDKQFTSVDDLQKHLLDMHTFVFFRCTLCQEVFDSKVSIQLHLAVKHSNEKKVYRCTSCNWD
FRNETDLQLHVKHNHLENQGKVHKCIFCGESFGTEVELQCHITTHSKKYNCKFCSKAFHAIILLEKHLREKHCVFETKTPNCGTNGASEQ
VQKEEVELQTLLTNSQESHNSHDGSEEDVDTSEPMYGCDICGAAYTMETLLQNHQLRDHNIRPGESAIVKKKAELIKGNYKCNVCSRTFF
SENGLREHMQTHLGPVKHYMCPICGERFPSLLTLTEHKVTHSKSLDTGNCRICKMPLQSEEEFLEHCQMHPDLRNSLTGFRCVVCMQTVT
STLELKIHGTFHMQKTGNGSAVQTTGRGQHVQKLYKCASCLKEFRSKQDLVKLDINGLPYGLCAGCVNLSKSASPGINVPPGTNRPGLGQ
NENLSAIEGKGKVGGLKTRCSSCNVKFESESELQNHIQTIHRELVPDSNSTQLKTPQVSPMPRISPSQSDEKKTYQCIKCQMVFYNEWDI
QVHVANHMIDEGLNHECKLCSQTFDSPAKLQCHLIEHSFEGMGGTFKCPVCFTVFVQANKLQQHIFSAHGQEDKIYDCTQCPQKFFFQTE

--------------------------------------------------------------

>62961_62961_5_PAX5-ZNF521_PAX5_chr9_36923352_ENST00000414447_ZNF521_chr18_22807664_ENST00000361524_length(amino acids)=1498AA_BP=258
MDLEKNYPTPRTSRTGHGGVNQLGGVFVNGRPLPDVVRQRIVELAHQGVRPCDISRQLRVSHGCVSKILGRYYETGSIKPGVIGGSKPKV
ATPKVVEKIAEYKRQNPTMFAWEIRDRLLAERVCDNDTVPSVSSINRIIRTKVQQPPNQPVPASSHSIGIQESPVPNGHSLPGRDFLRKQ
MRGDLFTQQQLEVLDRVFERQHYSDIFTTTEPIKPEQTTEYSAMASLAGGLDDMKANLASPTPADIGSSVPGPQSYPIVTDGVDVEDDPT
CSWPASSPSSKDQTSPSHGEGCDFGEEEGGPGLPYPCQFCDKSFSRLSYLKHHEQSHSDKLPFKCTYCSRLFKHKRSRDRHIKLHTGDKK
YHCSECDAAFSRSDHLKIHLKTHTSNKPYKCAICRRGFLSSSSLHGHMQVHERNKDGSQSGSRMEDWKMKDTQKCSQCEEGFDFPEDLQK
HIAECHPECSPNEDRAALQCVYCHELFVEETSLMNHMEQVHSGEKKNSCSICSESFHTVEELYSHMDSHQQPESCNHSNSPSLVTVGYTS
VSSTTPDSNLSVDSSTMVEAAPPIPKSRGRKRAAQQTPDMTGPSSKQAKVTYSCIYCNKQLFSSLAVLQIHLKTMHLDKPEQAHICQYCL
EVLPSLYNLNEHLKQVHEAQDPGLIVSAMPAIVYQCNFCSEVVNDLNTLQEHIRCSHGFANPAAKDSNAFFCPHCYMGFLTDSSLEEHIR
QVHCDLSGSRFGSPVLGTPKEPVVEVYSCSYCTNSPIFNSVLKLNKHIKENHKNIPLALNYIHNGKKSRALSPLSPVAIEQTSLKMMQAV
GGAPARPTGEYICNQCGAKYTSLDSFQTHLKTHLDTVLPKLTCPQCNKEFPNQESLLKHVTIHFMITSTYYICESCDKQFTSVDDLQKHL
LDMHTFVFFRCTLCQEVFDSKVSIQLHLAVKHSNEKKVYRCTSCNWDFRNETDLQLHVKHNHLENQGKVHKCIFCGESFGTEVELQCHIT
THSKKYNCKFCSKAFHAIILLEKHLREKHCVFETKTPNCGTNGASEQVQKEEVELQTLLTNSQESHNSHDGSEEDVDTSEPMYGCDICGA
AYTMETLLQNHQLRDHNIRPGESAIVKKKAELIKGNYKCNVCSRTFFSENGLREHMQTHLGPVKHYMCPICGERFPSLLTLTEHKVTHSK
SLDTGNCRICKMPLQSEEEFLEHCQMHPDLRNSLTGFRCVVCMQTVTSTLELKIHGTFHMQKTGNGSAVQTTGRGQHVQKLYKCASCLKE
FRSKQDLVKLDINGLPYGLCAGCVNLSKSASPGINVPPGTNRPGLGQNENLSAIEGKGKVGGLKTRCSSCNVKFESESELQNHIQTIHRE
LVPDSNSTQLKTPQVSPMPRISPSQSDEKKTYQCIKCQMVFYNEWDIQVHVANHMIDEGLNHECKLCSQTFDSPAKLQCHLIEHSFEGMG

--------------------------------------------------------------

>62961_62961_6_PAX5-ZNF521_PAX5_chr9_36923352_ENST00000446742_ZNF521_chr18_22807664_ENST00000361524_length(amino acids)=1475AA_BP=235
MDLEKNYPTPRTSRTGHGGVNQLGGVFVNGRPLPDVVRQRIVELAHQGVRPCDISRQLRVSHGCVSKILGRIIRTKVQQPPNQPVPASSH
SIVSTGSVTQVSSVSTDSAGSSYSISGILGITSPSADTNKRKRDEGIQESPVPNGHSLPGRDFLRKQMRGDLFTQQQLEVLDRVFERQHY
SDIFTTTEPIKPEQTTEYSAMASLAGGLDDMKANLASPTPADIGSSVPGPQSYPIVTDGVDVEDDPTCSWPASSPSSKDQTSPSHGEGCD
FGEEEGGPGLPYPCQFCDKSFSRLSYLKHHEQSHSDKLPFKCTYCSRLFKHKRSRDRHIKLHTGDKKYHCSECDAAFSRSDHLKIHLKTH
TSNKPYKCAICRRGFLSSSSLHGHMQVHERNKDGSQSGSRMEDWKMKDTQKCSQCEEGFDFPEDLQKHIAECHPECSPNEDRAALQCVYC
HELFVEETSLMNHMEQVHSGEKKNSCSICSESFHTVEELYSHMDSHQQPESCNHSNSPSLVTVGYTSVSSTTPDSNLSVDSSTMVEAAPP
IPKSRGRKRAAQQTPDMTGPSSKQAKVTYSCIYCNKQLFSSLAVLQIHLKTMHLDKPEQAHICQYCLEVLPSLYNLNEHLKQVHEAQDPG
LIVSAMPAIVYQCNFCSEVVNDLNTLQEHIRCSHGFANPAAKDSNAFFCPHCYMGFLTDSSLEEHIRQVHCDLSGSRFGSPVLGTPKEPV
VEVYSCSYCTNSPIFNSVLKLNKHIKENHKNIPLALNYIHNGKKSRALSPLSPVAIEQTSLKMMQAVGGAPARPTGEYICNQCGAKYTSL
DSFQTHLKTHLDTVLPKLTCPQCNKEFPNQESLLKHVTIHFMITSTYYICESCDKQFTSVDDLQKHLLDMHTFVFFRCTLCQEVFDSKVS
IQLHLAVKHSNEKKVYRCTSCNWDFRNETDLQLHVKHNHLENQGKVHKCIFCGESFGTEVELQCHITTHSKKYNCKFCSKAFHAIILLEK
HLREKHCVFETKTPNCGTNGASEQVQKEEVELQTLLTNSQESHNSHDGSEEDVDTSEPMYGCDICGAAYTMETLLQNHQLRDHNIRPGES
AIVKKKAELIKGNYKCNVCSRTFFSENGLREHMQTHLGPVKHYMCPICGERFPSLLTLTEHKVTHSKSLDTGNCRICKMPLQSEEEFLEH
CQMHPDLRNSLTGFRCVVCMQTVTSTLELKIHGTFHMQKTGNGSAVQTTGRGQHVQKLYKCASCLKEFRSKQDLVKLDINGLPYGLCAGC
VNLSKSASPGINVPPGTNRPGLGQNENLSAIEGKGKVGGLKTRCSSCNVKFESESELQNHIQTIHRELVPDSNSTQLKTPQVSPMPRISP
SQSDEKKTYQCIKCQMVFYNEWDIQVHVANHMIDEGLNHECKLCSQTFDSPAKLQCHLIEHSFEGMGGTFKCPVCFTVFVQANKLQQHIF

--------------------------------------------------------------

>62961_62961_7_PAX5-ZNF521_PAX5_chr9_36923352_ENST00000520281_ZNF521_chr18_22807664_ENST00000361524_length(amino acids)=1498AA_BP=258
MDLEKNYPTPRTSRTGHGGVNQLGGVFVNGRPLPDVVRQRIVELAHQGVRPCDISRQLRVSHGCVSKILGRYYETGSIKPGVIGGSKPKV
ATPKVVEKIAEYKRQNPTMFAWEIRDRLLAERVCDNDTVPSVSSINRIIRTKVQQPPNQPVPASSHSIGIQESPVPNGHSLPGRDFLRKQ
MRGDLFTQQQLEVLDRVFERQHYSDIFTTTEPIKPEQTTEYSAMASLAGGLDDMKANLASPTPADIGSSVPGPQSYPIVTDGVDVEDDPT
CSWPASSPSSKDQTSPSHGEGCDFGEEEGGPGLPYPCQFCDKSFSRLSYLKHHEQSHSDKLPFKCTYCSRLFKHKRSRDRHIKLHTGDKK
YHCSECDAAFSRSDHLKIHLKTHTSNKPYKCAICRRGFLSSSSLHGHMQVHERNKDGSQSGSRMEDWKMKDTQKCSQCEEGFDFPEDLQK
HIAECHPECSPNEDRAALQCVYCHELFVEETSLMNHMEQVHSGEKKNSCSICSESFHTVEELYSHMDSHQQPESCNHSNSPSLVTVGYTS
VSSTTPDSNLSVDSSTMVEAAPPIPKSRGRKRAAQQTPDMTGPSSKQAKVTYSCIYCNKQLFSSLAVLQIHLKTMHLDKPEQAHICQYCL
EVLPSLYNLNEHLKQVHEAQDPGLIVSAMPAIVYQCNFCSEVVNDLNTLQEHIRCSHGFANPAAKDSNAFFCPHCYMGFLTDSSLEEHIR
QVHCDLSGSRFGSPVLGTPKEPVVEVYSCSYCTNSPIFNSVLKLNKHIKENHKNIPLALNYIHNGKKSRALSPLSPVAIEQTSLKMMQAV
GGAPARPTGEYICNQCGAKYTSLDSFQTHLKTHLDTVLPKLTCPQCNKEFPNQESLLKHVTIHFMITSTYYICESCDKQFTSVDDLQKHL
LDMHTFVFFRCTLCQEVFDSKVSIQLHLAVKHSNEKKVYRCTSCNWDFRNETDLQLHVKHNHLENQGKVHKCIFCGESFGTEVELQCHIT
THSKKYNCKFCSKAFHAIILLEKHLREKHCVFETKTPNCGTNGASEQVQKEEVELQTLLTNSQESHNSHDGSEEDVDTSEPMYGCDICGA
AYTMETLLQNHQLRDHNIRPGESAIVKKKAELIKGNYKCNVCSRTFFSENGLREHMQTHLGPVKHYMCPICGERFPSLLTLTEHKVTHSK
SLDTGNCRICKMPLQSEEEFLEHCQMHPDLRNSLTGFRCVVCMQTVTSTLELKIHGTFHMQKTGNGSAVQTTGRGQHVQKLYKCASCLKE
FRSKQDLVKLDINGLPYGLCAGCVNLSKSASPGINVPPGTNRPGLGQNENLSAIEGKGKVGGLKTRCSSCNVKFESESELQNHIQTIHRE
LVPDSNSTQLKTPQVSPMPRISPSQSDEKKTYQCIKCQMVFYNEWDIQVHVANHMIDEGLNHECKLCSQTFDSPAKLQCHLIEHSFEGMG

--------------------------------------------------------------

Top

Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr9:36923352/chr18:22807664)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
PAX5

Q02548

.
FUNCTION: Transcription factor that plays an essential role in commitment of lymphoid progenitors to the B-lymphocyte lineage (PubMed:10811620, PubMed:27181361). Fulfills a dual role by repressing B-lineage inappropriate genes and simultaneously activating B-lineage-specific genes (PubMed:10811620, PubMed:27181361). In turn, regulates cell adhesion and migration, induces V(H)-to-D(H)J(H) recombination, facilitates pre-B-cell receptor signaling and promotes development to the mature B-cell stage (PubMed:32612238). Repression of the cohesin-release factor WAPL causes global changes of the chromosomal architecture in pro-B cells to facilitate the generation of a diverse antibody repertoire (PubMed:32612238). {ECO:0000269|PubMed:10811620, ECO:0000269|PubMed:27181361, ECO:0000269|PubMed:32612238}.; FUNCTION: (Microbial infection) Plays an essential role in the maintenance of Epstein-Barr virus genome copy number within the host cell by promoting EBNA1/oriP-dependent binding and transcription (PubMed:31941781). Participates also in the inhibition of lytic EBV reactivation by modulating viral BZLF1 activity (PubMed:23678172). {ECO:0000269|PubMed:23678172, ECO:0000269|PubMed:31941781}.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePAX5chr9:36923352chr18:22807664ENST00000358127-71016_142303.3333333333333392.0DNA bindingPaired
HgenePAX5chr9:36923352chr18:22807664ENST00000377847-7816_142303.3333333333333329.0DNA bindingPaired
HgenePAX5chr9:36923352chr18:22807664ENST00000377852-7916_142303.3333333333333358.0DNA bindingPaired
HgenePAX5chr9:36923352chr18:22807664ENST00000377853-7916_142303.3333333333333363.0DNA bindingPaired
HgenePAX5chr9:36923352chr18:22807664ENST00000414447-6916_142260.3333333333333349.0DNA bindingPaired
HgenePAX5chr9:36923352chr18:22807664ENST00000446742-6816_142237.33333333333334292.0DNA bindingPaired
HgenePAX5chr9:36923352chr18:22807664ENST00000520281-6816_142260.3333333333333320.0DNA bindingPaired
HgenePAX5chr9:36923352chr18:22807664ENST00000358127-71019_75303.3333333333333392.0RegionPAI subdomain
HgenePAX5chr9:36923352chr18:22807664ENST00000358127-71094_142303.3333333333333392.0RegionRED subdomain
HgenePAX5chr9:36923352chr18:22807664ENST00000377847-7819_75303.3333333333333329.0RegionPAI subdomain
HgenePAX5chr9:36923352chr18:22807664ENST00000377847-7894_142303.3333333333333329.0RegionRED subdomain
HgenePAX5chr9:36923352chr18:22807664ENST00000377852-7919_75303.3333333333333358.0RegionPAI subdomain
HgenePAX5chr9:36923352chr18:22807664ENST00000377852-7994_142303.3333333333333358.0RegionRED subdomain
HgenePAX5chr9:36923352chr18:22807664ENST00000377853-7919_75303.3333333333333363.0RegionPAI subdomain
HgenePAX5chr9:36923352chr18:22807664ENST00000377853-7994_142303.3333333333333363.0RegionRED subdomain
HgenePAX5chr9:36923352chr18:22807664ENST00000414447-6919_75260.3333333333333349.0RegionPAI subdomain
HgenePAX5chr9:36923352chr18:22807664ENST00000414447-6994_142260.3333333333333349.0RegionRED subdomain
HgenePAX5chr9:36923352chr18:22807664ENST00000446742-6819_75237.33333333333334292.0RegionPAI subdomain
HgenePAX5chr9:36923352chr18:22807664ENST00000446742-6894_142237.33333333333334292.0RegionRED subdomain
HgenePAX5chr9:36923352chr18:22807664ENST00000520281-6819_75260.3333333333333320.0RegionPAI subdomain
HgenePAX5chr9:36923352chr18:22807664ENST00000520281-6894_142260.3333333333333320.0RegionRED subdomain
TgeneZNF521chr9:36923352chr18:22807664ENST00000361524281020_104273.333333333333331312.0Zinc fingerC2H2-type 24
TgeneZNF521chr9:36923352chr18:22807664ENST00000361524281065_108373.333333333333331312.0Zinc fingerC2H2-type 25%3B degenerate
TgeneZNF521chr9:36923352chr18:22807664ENST00000361524281138_116173.333333333333331312.0Zinc fingerC2H2-type 26
TgeneZNF521chr9:36923352chr18:22807664ENST0000036152428118_14073.333333333333331312.0Zinc fingerC2H2-type 2
TgeneZNF521chr9:36923352chr18:22807664ENST00000361524281195_121773.333333333333331312.0Zinc fingerC2H2-type 27
TgeneZNF521chr9:36923352chr18:22807664ENST00000361524281225_124773.333333333333331312.0Zinc fingerC2H2-type 28
TgeneZNF521chr9:36923352chr18:22807664ENST00000361524281256_127973.333333333333331312.0Zinc fingerC2H2-type 29
TgeneZNF521chr9:36923352chr18:22807664ENST00000361524281286_130973.333333333333331312.0Zinc fingerC2H2-type 30
TgeneZNF521chr9:36923352chr18:22807664ENST0000036152428146_16873.333333333333331312.0Zinc fingerC2H2-type 3
TgeneZNF521chr9:36923352chr18:22807664ENST0000036152428174_19673.333333333333331312.0Zinc fingerC2H2-type 4
TgeneZNF521chr9:36923352chr18:22807664ENST0000036152428202_22473.333333333333331312.0Zinc fingerC2H2-type 5
TgeneZNF521chr9:36923352chr18:22807664ENST0000036152428246_26973.333333333333331312.0Zinc fingerC2H2-type 6
TgeneZNF521chr9:36923352chr18:22807664ENST0000036152428281_30473.333333333333331312.0Zinc fingerC2H2-type 7
TgeneZNF521chr9:36923352chr18:22807664ENST0000036152428310_33273.333333333333331312.0Zinc fingerC2H2-type 8
TgeneZNF521chr9:36923352chr18:22807664ENST0000036152428405_42973.333333333333331312.0Zinc fingerC2H2-type 9%3B degenerate
TgeneZNF521chr9:36923352chr18:22807664ENST0000036152428437_46073.333333333333331312.0Zinc fingerC2H2-type 10
TgeneZNF521chr9:36923352chr18:22807664ENST0000036152428477_50073.333333333333331312.0Zinc fingerC2H2-type 11
TgeneZNF521chr9:36923352chr18:22807664ENST0000036152428513_53673.333333333333331312.0Zinc fingerC2H2-type 12
TgeneZNF521chr9:36923352chr18:22807664ENST0000036152428560_58573.333333333333331312.0Zinc fingerC2H2-type 13%3B atypical
TgeneZNF521chr9:36923352chr18:22807664ENST0000036152428634_65673.333333333333331312.0Zinc fingerC2H2-type 14
TgeneZNF521chr9:36923352chr18:22807664ENST0000036152428664_68673.333333333333331312.0Zinc fingerC2H2-type 15
TgeneZNF521chr9:36923352chr18:22807664ENST0000036152428694_71773.333333333333331312.0Zinc fingerC2H2-type 16
TgeneZNF521chr9:36923352chr18:22807664ENST0000036152428722_74573.333333333333331312.0Zinc fingerC2H2-type 17
TgeneZNF521chr9:36923352chr18:22807664ENST0000036152428752_77573.333333333333331312.0Zinc fingerC2H2-type 18
TgeneZNF521chr9:36923352chr18:22807664ENST0000036152428783_80573.333333333333331312.0Zinc fingerC2H2-type 19
TgeneZNF521chr9:36923352chr18:22807664ENST0000036152428809_83273.333333333333331312.0Zinc fingerC2H2-type 20
TgeneZNF521chr9:36923352chr18:22807664ENST0000036152428886_90873.333333333333331312.0Zinc fingerC2H2-type 21%3B degenerate
TgeneZNF521chr9:36923352chr18:22807664ENST0000036152428930_95273.333333333333331312.0Zinc fingerC2H2-type 22
TgeneZNF521chr9:36923352chr18:22807664ENST0000036152428959_98173.333333333333331312.0Zinc fingerC2H2-type 23
TgeneZNF521chr9:36923352chr18:22807664ENST00000538137281020_104273.333333333333331312.0Zinc fingerC2H2-type 24
TgeneZNF521chr9:36923352chr18:22807664ENST00000538137281065_108373.333333333333331312.0Zinc fingerC2H2-type 25%3B degenerate
TgeneZNF521chr9:36923352chr18:22807664ENST00000538137281138_116173.333333333333331312.0Zinc fingerC2H2-type 26
TgeneZNF521chr9:36923352chr18:22807664ENST0000053813728118_14073.333333333333331312.0Zinc fingerC2H2-type 2
TgeneZNF521chr9:36923352chr18:22807664ENST00000538137281195_121773.333333333333331312.0Zinc fingerC2H2-type 27
TgeneZNF521chr9:36923352chr18:22807664ENST00000538137281225_124773.333333333333331312.0Zinc fingerC2H2-type 28
TgeneZNF521chr9:36923352chr18:22807664ENST00000538137281256_127973.333333333333331312.0Zinc fingerC2H2-type 29
TgeneZNF521chr9:36923352chr18:22807664ENST00000538137281286_130973.333333333333331312.0Zinc fingerC2H2-type 30
TgeneZNF521chr9:36923352chr18:22807664ENST0000053813728146_16873.333333333333331312.0Zinc fingerC2H2-type 3
TgeneZNF521chr9:36923352chr18:22807664ENST0000053813728174_19673.333333333333331312.0Zinc fingerC2H2-type 4
TgeneZNF521chr9:36923352chr18:22807664ENST0000053813728202_22473.333333333333331312.0Zinc fingerC2H2-type 5
TgeneZNF521chr9:36923352chr18:22807664ENST0000053813728246_26973.333333333333331312.0Zinc fingerC2H2-type 6
TgeneZNF521chr9:36923352chr18:22807664ENST0000053813728281_30473.333333333333331312.0Zinc fingerC2H2-type 7
TgeneZNF521chr9:36923352chr18:22807664ENST0000053813728310_33273.333333333333331312.0Zinc fingerC2H2-type 8
TgeneZNF521chr9:36923352chr18:22807664ENST0000053813728405_42973.333333333333331312.0Zinc fingerC2H2-type 9%3B degenerate
TgeneZNF521chr9:36923352chr18:22807664ENST0000053813728437_46073.333333333333331312.0Zinc fingerC2H2-type 10
TgeneZNF521chr9:36923352chr18:22807664ENST0000053813728477_50073.333333333333331312.0Zinc fingerC2H2-type 11
TgeneZNF521chr9:36923352chr18:22807664ENST0000053813728513_53673.333333333333331312.0Zinc fingerC2H2-type 12
TgeneZNF521chr9:36923352chr18:22807664ENST0000053813728560_58573.333333333333331312.0Zinc fingerC2H2-type 13%3B atypical
TgeneZNF521chr9:36923352chr18:22807664ENST0000053813728634_65673.333333333333331312.0Zinc fingerC2H2-type 14
TgeneZNF521chr9:36923352chr18:22807664ENST0000053813728664_68673.333333333333331312.0Zinc fingerC2H2-type 15
TgeneZNF521chr9:36923352chr18:22807664ENST0000053813728694_71773.333333333333331312.0Zinc fingerC2H2-type 16
TgeneZNF521chr9:36923352chr18:22807664ENST0000053813728722_74573.333333333333331312.0Zinc fingerC2H2-type 17
TgeneZNF521chr9:36923352chr18:22807664ENST0000053813728752_77573.333333333333331312.0Zinc fingerC2H2-type 18
TgeneZNF521chr9:36923352chr18:22807664ENST0000053813728783_80573.333333333333331312.0Zinc fingerC2H2-type 19
TgeneZNF521chr9:36923352chr18:22807664ENST0000053813728809_83273.333333333333331312.0Zinc fingerC2H2-type 20
TgeneZNF521chr9:36923352chr18:22807664ENST0000053813728886_90873.333333333333331312.0Zinc fingerC2H2-type 21%3B degenerate
TgeneZNF521chr9:36923352chr18:22807664ENST0000053813728930_95273.333333333333331312.0Zinc fingerC2H2-type 22
TgeneZNF521chr9:36923352chr18:22807664ENST0000053813728959_98173.333333333333331312.0Zinc fingerC2H2-type 23

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneZNF521chr9:36923352chr18:22807664ENST000003615242847_6773.333333333333331312.0Zinc fingerC2H2-type 1%3B degenerate
TgeneZNF521chr9:36923352chr18:22807664ENST000005381372847_6773.333333333333331312.0Zinc fingerC2H2-type 1%3B degenerate


Top

Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors
PAX5TLE4, DAXX, RUNX1, MYB, ID3, EP300, TBP, RB1, MAPK1, KAT2B, CDKN1B, UBE3A, RAD52, HMGB3, HOXC8, MAPK9, NFYC, FBLN1, GRHL2, DTX2, CSNK2A1, UBE2I, CCNC, BCAS2, C1orf109, GNG13, ZMYM5, SEC14L4, RNF144B, OSGIN1, CIB3, SAE1, STAC, TLK2, HMBOX1, NGLY1, NEIL2, LONRF1, LDLRAP1, LARP4, UBXN7, ACOT12, CKS1B, KLHL38, HGS, CXorf38, KRTAP10-8, PNMA5, KRTAP9-3, UBXN2B, CDK3, BKRF1, HIST1H3A, PAX8, KLHL14,


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
PAX5all structure
ZNF521


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

Related Drugs to PAX5-ZNF521


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

Top

Related Diseases to PAX5-ZNF521


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgenePAX5C0006413Burkitt Lymphoma4ORPHANET
HgenePAX5C1292769Precursor B-cell lymphoblastic leukemia4ORPHANET
HgenePAX5C0023485Precursor B-Cell Lymphoblastic Leukemia-Lymphoma2CTD_human
HgenePAX5C1961102Precursor Cell Lymphoblastic Leukemia Lymphoma2CGI;CTD_human;UNIPROT
HgenePAX5C0023452Childhood Acute Lymphoblastic Leukemia1CTD_human
HgenePAX5C0023453L2 Acute Lymphoblastic Leukemia1CTD_human
HgenePAX5C1535926Neurodevelopmental Disorders1CTD_human