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	Fusion Gene Summary
	Fusion Gene Sample Information
	Fusion ORF Analysis
	Fusion Amino Acid Sequences
	Fusion Protein Functional Features
	Fusion Protein-Protein Interaction
	Related drugs with this fusion protein
	Related disease with this fusion protein

Fusion Protein:PAX8-NFE2L2

Fusion Protein Summary

Fusion gene summary

Fusion partner gene information	Fusion gene name: PAX8-NFE2L2
	FusionPDB ID: 62972
	FusionGDB2.0 ID: 62972
		Hgene	Tgene
	Gene symbol	PAX8	NFE2L2
	Gene ID	7849	4780
	Gene name	paired box 8	nuclear factor, erythroid 2 like 2
	Synonyms	-	HEBP1\|IMDDHH\|NRF2\|Nrf-2
	Cytomap	2q14.1	2q31.2
	Type of gene	protein-coding	protein-coding
	Description	paired box protein Pax-8paired domain gene 8	nuclear factor erythroid 2-related factor 2nuclear factor erythroid-derived 2-like 2
	Modification date	20200313	20200329
	UniProtAcc	Q06710	Q16236
Ensembl transtripts involved in fusion gene	ENST ids	ENST00000263334, ENST00000263335, ENST00000348715, ENST00000397647, ENST00000429538,	ENST00000423513, ENST00000446151, ENST00000464747, ENST00000397062, ENST00000397063,
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)	* DoF score	7 X 10 X 5=350	23 X 16 X 12=4416
	# samples	13	28
	** MAII score	log2(13/350*10)=-1.42884329880387 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(28/4416*10)=-3.9792414398332 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)	PubMed: PAX8 [Title/Abstract] AND NFE2L2 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)	PAX8(113999128)-NFE2L2(178097311), # samples:3
Anticipated loss of major functional domain due to fusion event.	PAX8-NFE2L2 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. PAX8-NFE2L2 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. PAX8-NFE2L2 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. PAX8-NFE2L2 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. PAX8-NFE2L2 seems lost the major protein functional domain in Hgene partner, which is a CGC due to the frame-shifted ORF. PAX8-NFE2L2 seems lost the major protein functional domain in Hgene partner, which is a transcription factor due to the frame-shifted ORF. PAX8-NFE2L2 seems lost the major protein functional domain in Tgene partner, which is a CGC due to the frame-shifted ORF. PAX8-NFE2L2 seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF. PAX8-NFE2L2 seems lost the major protein functional domain in Tgene partner, which is a transcription factor due to the frame-shifted ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	PAX8	GO:0006351	transcription, DNA-templated	9590296
Hgene	PAX8	GO:0045893	positive regulation of transcription, DNA-templated	9388203\|15356023\|15961562
Hgene	PAX8	GO:0045944	positive regulation of transcription by RNA polymerase II	9388203
Hgene	PAX8	GO:0071371	cellular response to gonadotropin stimulus	15961562
Tgene	NFE2L2	GO:0010499	proteasomal ubiquitin-independent protein catabolic process	19424503
Tgene	NFE2L2	GO:0016567	protein ubiquitination	15983046
Tgene	NFE2L2	GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	15983046
Tgene	NFE2L2	GO:0045944	positive regulation of transcription by RNA polymerase II	17015834
Tgene	NFE2L2	GO:0071498	cellular response to fluid shear stress	25190803

Fusion gene breakpoints across PAX8 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across NFE2L2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

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Fusion Gene Sample Information

Fusion gene information from FusionGDB2.0.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	THCA	TCGA-EM-A2CP-01A	PAX8	chr2	113999128	-	NFE2L2	chr2	178097311	-
ChimerDB4	THCA	TCGA-EM-A2CP	PAX8	chr2	113999127	-	NFE2L2	chr2	178097311	-

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Fusion ORF Analysis

Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000348715	PAX8	chr2	113999128	-	ENST00000397063	NFE2L2	chr2	178097311	-	2829	933	63	2348	761
ENST00000348715	PAX8	chr2	113999128	-	ENST00000397062	NFE2L2	chr2	178097311	-	2829	933	63	2348	761
ENST00000397647	PAX8	chr2	113999128	-	ENST00000397063	NFE2L2	chr2	178097311	-	2829	933	63	2348	761
ENST00000397647	PAX8	chr2	113999128	-	ENST00000397062	NFE2L2	chr2	178097311	-	2829	933	63	2348	761
ENST00000263335	PAX8	chr2	113999128	-	ENST00000397063	NFE2L2	chr2	178097311	-	2829	933	63	2348	761
ENST00000263335	PAX8	chr2	113999128	-	ENST00000397062	NFE2L2	chr2	178097311	-	2829	933	63	2348	761
ENST00000263334	PAX8	chr2	113999128	-	ENST00000397063	NFE2L2	chr2	178097311	-	2673	777	0	2192	730
ENST00000263334	PAX8	chr2	113999128	-	ENST00000397062	NFE2L2	chr2	178097311	-	2673	777	0	2192	730
ENST00000348715	PAX8	chr2	113999127	-	ENST00000397063	NFE2L2	chr2	178097311	-	2829	933	63	2348	761
ENST00000348715	PAX8	chr2	113999127	-	ENST00000397062	NFE2L2	chr2	178097311	-	2829	933	63	2348	761
ENST00000397647	PAX8	chr2	113999127	-	ENST00000397063	NFE2L2	chr2	178097311	-	2829	933	63	2348	761
ENST00000397647	PAX8	chr2	113999127	-	ENST00000397062	NFE2L2	chr2	178097311	-	2829	933	63	2348	761
ENST00000263335	PAX8	chr2	113999127	-	ENST00000397063	NFE2L2	chr2	178097311	-	2829	933	63	2348	761
ENST00000263335	PAX8	chr2	113999127	-	ENST00000397062	NFE2L2	chr2	178097311	-	2829	933	63	2348	761
ENST00000263334	PAX8	chr2	113999127	-	ENST00000397063	NFE2L2	chr2	178097311	-	2673	777	0	2192	730
ENST00000263334	PAX8	chr2	113999127	-	ENST00000397062	NFE2L2	chr2	178097311	-	2673	777	0	2192	730

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000348715	ENST00000397063	PAX8	chr2	113999128	-	NFE2L2	chr2	178097311	-	0.004127932	0.9958721
ENST00000348715	ENST00000397062	PAX8	chr2	113999128	-	NFE2L2	chr2	178097311	-	0.004127932	0.9958721
ENST00000397647	ENST00000397063	PAX8	chr2	113999128	-	NFE2L2	chr2	178097311	-	0.004127932	0.9958721
ENST00000397647	ENST00000397062	PAX8	chr2	113999128	-	NFE2L2	chr2	178097311	-	0.004127932	0.9958721
ENST00000263335	ENST00000397063	PAX8	chr2	113999128	-	NFE2L2	chr2	178097311	-	0.004127932	0.9958721
ENST00000263335	ENST00000397062	PAX8	chr2	113999128	-	NFE2L2	chr2	178097311	-	0.004127932	0.9958721
ENST00000263334	ENST00000397063	PAX8	chr2	113999128	-	NFE2L2	chr2	178097311	-	0.003884635	0.9961153
ENST00000263334	ENST00000397062	PAX8	chr2	113999128	-	NFE2L2	chr2	178097311	-	0.003884635	0.9961153
ENST00000348715	ENST00000397063	PAX8	chr2	113999127	-	NFE2L2	chr2	178097311	-	0.004127932	0.9958721
ENST00000348715	ENST00000397062	PAX8	chr2	113999127	-	NFE2L2	chr2	178097311	-	0.004127932	0.9958721
ENST00000397647	ENST00000397063	PAX8	chr2	113999127	-	NFE2L2	chr2	178097311	-	0.004127932	0.9958721
ENST00000397647	ENST00000397062	PAX8	chr2	113999127	-	NFE2L2	chr2	178097311	-	0.004127932	0.9958721
ENST00000263335	ENST00000397063	PAX8	chr2	113999127	-	NFE2L2	chr2	178097311	-	0.004127932	0.9958721
ENST00000263335	ENST00000397062	PAX8	chr2	113999127	-	NFE2L2	chr2	178097311	-	0.004127932	0.9958721
ENST00000263334	ENST00000397063	PAX8	chr2	113999127	-	NFE2L2	chr2	178097311	-	0.003884635	0.9961153
ENST00000263334	ENST00000397062	PAX8	chr2	113999127	-	NFE2L2	chr2	178097311	-	0.003884635	0.9961153

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Fusion Amino Acid Sequences

For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>62972_62972_1_PAX8-NFE2L2_PAX8_chr2_113999127_ENST00000263334_NFE2L2_chr2_178097311_ENST00000397062_length(amino acids)=730AA_BP=259
MPHNSIRSGHGGLNQLGGAFVNGRPLPEVVRQRIVDLAHQGVRPCDISRQLRVSHGCVSKILGRYYETGSIRPGVIGGSKPKVATPKVVE
KIGDYKRQNPTMFAWEIRDRLLAEGVCDNDTVPSVSSINRIIRTKVQQPFNLPMDSCVATKSLSPGHTLIPSSAVTPPESPQSDSLGSTY
SINGLLGIAQPGSDKRKMDDSDQDSCRLSIDSQSSSSGPRKHLRTDAFSQHHLEPLECPFERQHYPEAYASPSHTKGEQVSSATFQSLVP
DIPGHIESPVFIATNQAQSPETSVAQVAPVDLDGMQQDIEQVWEELLSIPELQCLNIENDKLVETTMVPSPEAKLTEVDNYHFYSSIPSM
EKEVGNCSPHFLNAFEDSFSSILSTEDPNQLTVNSLNSDATVNTDFGDEFYSAFIAEPSISNSMPSPATLSHSLSELLNGPIDVSDLSLC
KAFNQNHPESTAEFNDSDSGISLNTSPSVASPEHSVESSSYGDTLLGLSDSEVEELDSAPGSVKQNGPKTPVHSSGDMVQPLSPSQGQST
HVHDAQCENTPEKELPVSPGHRKTPFTKDKHSSRLEAHLTRDELRAKALHIPFPVEKIINLPVVDFNEMMSKEQFNEAQLALIRDIRRRG
KNKVAAQNCRKRKLENIVELEQDLDHLKDEKEKLLKEKGENDKSLHLLKKQLSTLYLEVFSMLRDEDGKPYSPSEYSLQQTRDGNVFLVP

--------------------------------------------------------------

>62972_62972_2_PAX8-NFE2L2_PAX8_chr2_113999127_ENST00000263334_NFE2L2_chr2_178097311_ENST00000397063_length(amino acids)=730AA_BP=259
MPHNSIRSGHGGLNQLGGAFVNGRPLPEVVRQRIVDLAHQGVRPCDISRQLRVSHGCVSKILGRYYETGSIRPGVIGGSKPKVATPKVVE
KIGDYKRQNPTMFAWEIRDRLLAEGVCDNDTVPSVSSINRIIRTKVQQPFNLPMDSCVATKSLSPGHTLIPSSAVTPPESPQSDSLGSTY
SINGLLGIAQPGSDKRKMDDSDQDSCRLSIDSQSSSSGPRKHLRTDAFSQHHLEPLECPFERQHYPEAYASPSHTKGEQVSSATFQSLVP
DIPGHIESPVFIATNQAQSPETSVAQVAPVDLDGMQQDIEQVWEELLSIPELQCLNIENDKLVETTMVPSPEAKLTEVDNYHFYSSIPSM
EKEVGNCSPHFLNAFEDSFSSILSTEDPNQLTVNSLNSDATVNTDFGDEFYSAFIAEPSISNSMPSPATLSHSLSELLNGPIDVSDLSLC
KAFNQNHPESTAEFNDSDSGISLNTSPSVASPEHSVESSSYGDTLLGLSDSEVEELDSAPGSVKQNGPKTPVHSSGDMVQPLSPSQGQST
HVHDAQCENTPEKELPVSPGHRKTPFTKDKHSSRLEAHLTRDELRAKALHIPFPVEKIINLPVVDFNEMMSKEQFNEAQLALIRDIRRRG
KNKVAAQNCRKRKLENIVELEQDLDHLKDEKEKLLKEKGENDKSLHLLKKQLSTLYLEVFSMLRDEDGKPYSPSEYSLQQTRDGNVFLVP

--------------------------------------------------------------

>62972_62972_3_PAX8-NFE2L2_PAX8_chr2_113999127_ENST00000263335_NFE2L2_chr2_178097311_ENST00000397062_length(amino acids)=761AA_BP=290
MQPAGQGSGRRGPDLREEAPSPRRAASDSPAMPHNSIRSGHGGLNQLGGAFVNGRPLPEVVRQRIVDLAHQGVRPCDISRQLRVSHGCVS
KILGRYYETGSIRPGVIGGSKPKVATPKVVEKIGDYKRQNPTMFAWEIRDRLLAEGVCDNDTVPSVSSINRIIRTKVQQPFNLPMDSCVA
TKSLSPGHTLIPSSAVTPPESPQSDSLGSTYSINGLLGIAQPGSDKRKMDDSDQDSCRLSIDSQSSSSGPRKHLRTDAFSQHHLEPLECP
FERQHYPEAYASPSHTKGEQVSSATFQSLVPDIPGHIESPVFIATNQAQSPETSVAQVAPVDLDGMQQDIEQVWEELLSIPELQCLNIEN
DKLVETTMVPSPEAKLTEVDNYHFYSSIPSMEKEVGNCSPHFLNAFEDSFSSILSTEDPNQLTVNSLNSDATVNTDFGDEFYSAFIAEPS
ISNSMPSPATLSHSLSELLNGPIDVSDLSLCKAFNQNHPESTAEFNDSDSGISLNTSPSVASPEHSVESSSYGDTLLGLSDSEVEELDSA
PGSVKQNGPKTPVHSSGDMVQPLSPSQGQSTHVHDAQCENTPEKELPVSPGHRKTPFTKDKHSSRLEAHLTRDELRAKALHIPFPVEKII
NLPVVDFNEMMSKEQFNEAQLALIRDIRRRGKNKVAAQNCRKRKLENIVELEQDLDHLKDEKEKLLKEKGENDKSLHLLKKQLSTLYLEV

--------------------------------------------------------------

>62972_62972_4_PAX8-NFE2L2_PAX8_chr2_113999127_ENST00000263335_NFE2L2_chr2_178097311_ENST00000397063_length(amino acids)=761AA_BP=290
MQPAGQGSGRRGPDLREEAPSPRRAASDSPAMPHNSIRSGHGGLNQLGGAFVNGRPLPEVVRQRIVDLAHQGVRPCDISRQLRVSHGCVS
KILGRYYETGSIRPGVIGGSKPKVATPKVVEKIGDYKRQNPTMFAWEIRDRLLAEGVCDNDTVPSVSSINRIIRTKVQQPFNLPMDSCVA
TKSLSPGHTLIPSSAVTPPESPQSDSLGSTYSINGLLGIAQPGSDKRKMDDSDQDSCRLSIDSQSSSSGPRKHLRTDAFSQHHLEPLECP
FERQHYPEAYASPSHTKGEQVSSATFQSLVPDIPGHIESPVFIATNQAQSPETSVAQVAPVDLDGMQQDIEQVWEELLSIPELQCLNIEN
DKLVETTMVPSPEAKLTEVDNYHFYSSIPSMEKEVGNCSPHFLNAFEDSFSSILSTEDPNQLTVNSLNSDATVNTDFGDEFYSAFIAEPS
ISNSMPSPATLSHSLSELLNGPIDVSDLSLCKAFNQNHPESTAEFNDSDSGISLNTSPSVASPEHSVESSSYGDTLLGLSDSEVEELDSA
PGSVKQNGPKTPVHSSGDMVQPLSPSQGQSTHVHDAQCENTPEKELPVSPGHRKTPFTKDKHSSRLEAHLTRDELRAKALHIPFPVEKII
NLPVVDFNEMMSKEQFNEAQLALIRDIRRRGKNKVAAQNCRKRKLENIVELEQDLDHLKDEKEKLLKEKGENDKSLHLLKKQLSTLYLEV

--------------------------------------------------------------

>62972_62972_5_PAX8-NFE2L2_PAX8_chr2_113999127_ENST00000348715_NFE2L2_chr2_178097311_ENST00000397062_length(amino acids)=761AA_BP=290
MQPAGQGSGRRGPDLREEAPSPRRAASDSPAMPHNSIRSGHGGLNQLGGAFVNGRPLPEVVRQRIVDLAHQGVRPCDISRQLRVSHGCVS
KILGRYYETGSIRPGVIGGSKPKVATPKVVEKIGDYKRQNPTMFAWEIRDRLLAEGVCDNDTVPSVSSINRIIRTKVQQPFNLPMDSCVA
TKSLSPGHTLIPSSAVTPPESPQSDSLGSTYSINGLLGIAQPGSDKRKMDDSDQDSCRLSIDSQSSSSGPRKHLRTDAFSQHHLEPLECP
FERQHYPEAYASPSHTKGEQVSSATFQSLVPDIPGHIESPVFIATNQAQSPETSVAQVAPVDLDGMQQDIEQVWEELLSIPELQCLNIEN
DKLVETTMVPSPEAKLTEVDNYHFYSSIPSMEKEVGNCSPHFLNAFEDSFSSILSTEDPNQLTVNSLNSDATVNTDFGDEFYSAFIAEPS
ISNSMPSPATLSHSLSELLNGPIDVSDLSLCKAFNQNHPESTAEFNDSDSGISLNTSPSVASPEHSVESSSYGDTLLGLSDSEVEELDSA
PGSVKQNGPKTPVHSSGDMVQPLSPSQGQSTHVHDAQCENTPEKELPVSPGHRKTPFTKDKHSSRLEAHLTRDELRAKALHIPFPVEKII
NLPVVDFNEMMSKEQFNEAQLALIRDIRRRGKNKVAAQNCRKRKLENIVELEQDLDHLKDEKEKLLKEKGENDKSLHLLKKQLSTLYLEV

--------------------------------------------------------------

>62972_62972_6_PAX8-NFE2L2_PAX8_chr2_113999127_ENST00000348715_NFE2L2_chr2_178097311_ENST00000397063_length(amino acids)=761AA_BP=290
MQPAGQGSGRRGPDLREEAPSPRRAASDSPAMPHNSIRSGHGGLNQLGGAFVNGRPLPEVVRQRIVDLAHQGVRPCDISRQLRVSHGCVS
KILGRYYETGSIRPGVIGGSKPKVATPKVVEKIGDYKRQNPTMFAWEIRDRLLAEGVCDNDTVPSVSSINRIIRTKVQQPFNLPMDSCVA
TKSLSPGHTLIPSSAVTPPESPQSDSLGSTYSINGLLGIAQPGSDKRKMDDSDQDSCRLSIDSQSSSSGPRKHLRTDAFSQHHLEPLECP
FERQHYPEAYASPSHTKGEQVSSATFQSLVPDIPGHIESPVFIATNQAQSPETSVAQVAPVDLDGMQQDIEQVWEELLSIPELQCLNIEN
DKLVETTMVPSPEAKLTEVDNYHFYSSIPSMEKEVGNCSPHFLNAFEDSFSSILSTEDPNQLTVNSLNSDATVNTDFGDEFYSAFIAEPS
ISNSMPSPATLSHSLSELLNGPIDVSDLSLCKAFNQNHPESTAEFNDSDSGISLNTSPSVASPEHSVESSSYGDTLLGLSDSEVEELDSA
PGSVKQNGPKTPVHSSGDMVQPLSPSQGQSTHVHDAQCENTPEKELPVSPGHRKTPFTKDKHSSRLEAHLTRDELRAKALHIPFPVEKII
NLPVVDFNEMMSKEQFNEAQLALIRDIRRRGKNKVAAQNCRKRKLENIVELEQDLDHLKDEKEKLLKEKGENDKSLHLLKKQLSTLYLEV

--------------------------------------------------------------

>62972_62972_7_PAX8-NFE2L2_PAX8_chr2_113999127_ENST00000397647_NFE2L2_chr2_178097311_ENST00000397062_length(amino acids)=761AA_BP=290
MQPAGQGSGRRGPDLREEAPSPRRAASDSPAMPHNSIRSGHGGLNQLGGAFVNGRPLPEVVRQRIVDLAHQGVRPCDISRQLRVSHGCVS
KILGRYYETGSIRPGVIGGSKPKVATPKVVEKIGDYKRQNPTMFAWEIRDRLLAEGVCDNDTVPSVSSINRIIRTKVQQPFNLPMDSCVA
TKSLSPGHTLIPSSAVTPPESPQSDSLGSTYSINGLLGIAQPGSDKRKMDDSDQDSCRLSIDSQSSSSGPRKHLRTDAFSQHHLEPLECP
FERQHYPEAYASPSHTKGEQVSSATFQSLVPDIPGHIESPVFIATNQAQSPETSVAQVAPVDLDGMQQDIEQVWEELLSIPELQCLNIEN
DKLVETTMVPSPEAKLTEVDNYHFYSSIPSMEKEVGNCSPHFLNAFEDSFSSILSTEDPNQLTVNSLNSDATVNTDFGDEFYSAFIAEPS
ISNSMPSPATLSHSLSELLNGPIDVSDLSLCKAFNQNHPESTAEFNDSDSGISLNTSPSVASPEHSVESSSYGDTLLGLSDSEVEELDSA
PGSVKQNGPKTPVHSSGDMVQPLSPSQGQSTHVHDAQCENTPEKELPVSPGHRKTPFTKDKHSSRLEAHLTRDELRAKALHIPFPVEKII
NLPVVDFNEMMSKEQFNEAQLALIRDIRRRGKNKVAAQNCRKRKLENIVELEQDLDHLKDEKEKLLKEKGENDKSLHLLKKQLSTLYLEV

--------------------------------------------------------------

>62972_62972_8_PAX8-NFE2L2_PAX8_chr2_113999127_ENST00000397647_NFE2L2_chr2_178097311_ENST00000397063_length(amino acids)=761AA_BP=290
MQPAGQGSGRRGPDLREEAPSPRRAASDSPAMPHNSIRSGHGGLNQLGGAFVNGRPLPEVVRQRIVDLAHQGVRPCDISRQLRVSHGCVS
KILGRYYETGSIRPGVIGGSKPKVATPKVVEKIGDYKRQNPTMFAWEIRDRLLAEGVCDNDTVPSVSSINRIIRTKVQQPFNLPMDSCVA
TKSLSPGHTLIPSSAVTPPESPQSDSLGSTYSINGLLGIAQPGSDKRKMDDSDQDSCRLSIDSQSSSSGPRKHLRTDAFSQHHLEPLECP
FERQHYPEAYASPSHTKGEQVSSATFQSLVPDIPGHIESPVFIATNQAQSPETSVAQVAPVDLDGMQQDIEQVWEELLSIPELQCLNIEN
DKLVETTMVPSPEAKLTEVDNYHFYSSIPSMEKEVGNCSPHFLNAFEDSFSSILSTEDPNQLTVNSLNSDATVNTDFGDEFYSAFIAEPS
ISNSMPSPATLSHSLSELLNGPIDVSDLSLCKAFNQNHPESTAEFNDSDSGISLNTSPSVASPEHSVESSSYGDTLLGLSDSEVEELDSA
PGSVKQNGPKTPVHSSGDMVQPLSPSQGQSTHVHDAQCENTPEKELPVSPGHRKTPFTKDKHSSRLEAHLTRDELRAKALHIPFPVEKII
NLPVVDFNEMMSKEQFNEAQLALIRDIRRRGKNKVAAQNCRKRKLENIVELEQDLDHLKDEKEKLLKEKGENDKSLHLLKKQLSTLYLEV

--------------------------------------------------------------

>62972_62972_9_PAX8-NFE2L2_PAX8_chr2_113999128_ENST00000263334_NFE2L2_chr2_178097311_ENST00000397062_length(amino acids)=730AA_BP=259
MPHNSIRSGHGGLNQLGGAFVNGRPLPEVVRQRIVDLAHQGVRPCDISRQLRVSHGCVSKILGRYYETGSIRPGVIGGSKPKVATPKVVE
KIGDYKRQNPTMFAWEIRDRLLAEGVCDNDTVPSVSSINRIIRTKVQQPFNLPMDSCVATKSLSPGHTLIPSSAVTPPESPQSDSLGSTY
SINGLLGIAQPGSDKRKMDDSDQDSCRLSIDSQSSSSGPRKHLRTDAFSQHHLEPLECPFERQHYPEAYASPSHTKGEQVSSATFQSLVP
DIPGHIESPVFIATNQAQSPETSVAQVAPVDLDGMQQDIEQVWEELLSIPELQCLNIENDKLVETTMVPSPEAKLTEVDNYHFYSSIPSM
EKEVGNCSPHFLNAFEDSFSSILSTEDPNQLTVNSLNSDATVNTDFGDEFYSAFIAEPSISNSMPSPATLSHSLSELLNGPIDVSDLSLC
KAFNQNHPESTAEFNDSDSGISLNTSPSVASPEHSVESSSYGDTLLGLSDSEVEELDSAPGSVKQNGPKTPVHSSGDMVQPLSPSQGQST
HVHDAQCENTPEKELPVSPGHRKTPFTKDKHSSRLEAHLTRDELRAKALHIPFPVEKIINLPVVDFNEMMSKEQFNEAQLALIRDIRRRG
KNKVAAQNCRKRKLENIVELEQDLDHLKDEKEKLLKEKGENDKSLHLLKKQLSTLYLEVFSMLRDEDGKPYSPSEYSLQQTRDGNVFLVP

--------------------------------------------------------------

>62972_62972_10_PAX8-NFE2L2_PAX8_chr2_113999128_ENST00000263334_NFE2L2_chr2_178097311_ENST00000397063_length(amino acids)=730AA_BP=259
MPHNSIRSGHGGLNQLGGAFVNGRPLPEVVRQRIVDLAHQGVRPCDISRQLRVSHGCVSKILGRYYETGSIRPGVIGGSKPKVATPKVVE
KIGDYKRQNPTMFAWEIRDRLLAEGVCDNDTVPSVSSINRIIRTKVQQPFNLPMDSCVATKSLSPGHTLIPSSAVTPPESPQSDSLGSTY
SINGLLGIAQPGSDKRKMDDSDQDSCRLSIDSQSSSSGPRKHLRTDAFSQHHLEPLECPFERQHYPEAYASPSHTKGEQVSSATFQSLVP
DIPGHIESPVFIATNQAQSPETSVAQVAPVDLDGMQQDIEQVWEELLSIPELQCLNIENDKLVETTMVPSPEAKLTEVDNYHFYSSIPSM
EKEVGNCSPHFLNAFEDSFSSILSTEDPNQLTVNSLNSDATVNTDFGDEFYSAFIAEPSISNSMPSPATLSHSLSELLNGPIDVSDLSLC
KAFNQNHPESTAEFNDSDSGISLNTSPSVASPEHSVESSSYGDTLLGLSDSEVEELDSAPGSVKQNGPKTPVHSSGDMVQPLSPSQGQST
HVHDAQCENTPEKELPVSPGHRKTPFTKDKHSSRLEAHLTRDELRAKALHIPFPVEKIINLPVVDFNEMMSKEQFNEAQLALIRDIRRRG
KNKVAAQNCRKRKLENIVELEQDLDHLKDEKEKLLKEKGENDKSLHLLKKQLSTLYLEVFSMLRDEDGKPYSPSEYSLQQTRDGNVFLVP

--------------------------------------------------------------

>62972_62972_11_PAX8-NFE2L2_PAX8_chr2_113999128_ENST00000263335_NFE2L2_chr2_178097311_ENST00000397062_length(amino acids)=761AA_BP=290
MQPAGQGSGRRGPDLREEAPSPRRAASDSPAMPHNSIRSGHGGLNQLGGAFVNGRPLPEVVRQRIVDLAHQGVRPCDISRQLRVSHGCVS
KILGRYYETGSIRPGVIGGSKPKVATPKVVEKIGDYKRQNPTMFAWEIRDRLLAEGVCDNDTVPSVSSINRIIRTKVQQPFNLPMDSCVA
TKSLSPGHTLIPSSAVTPPESPQSDSLGSTYSINGLLGIAQPGSDKRKMDDSDQDSCRLSIDSQSSSSGPRKHLRTDAFSQHHLEPLECP
FERQHYPEAYASPSHTKGEQVSSATFQSLVPDIPGHIESPVFIATNQAQSPETSVAQVAPVDLDGMQQDIEQVWEELLSIPELQCLNIEN
DKLVETTMVPSPEAKLTEVDNYHFYSSIPSMEKEVGNCSPHFLNAFEDSFSSILSTEDPNQLTVNSLNSDATVNTDFGDEFYSAFIAEPS
ISNSMPSPATLSHSLSELLNGPIDVSDLSLCKAFNQNHPESTAEFNDSDSGISLNTSPSVASPEHSVESSSYGDTLLGLSDSEVEELDSA
PGSVKQNGPKTPVHSSGDMVQPLSPSQGQSTHVHDAQCENTPEKELPVSPGHRKTPFTKDKHSSRLEAHLTRDELRAKALHIPFPVEKII
NLPVVDFNEMMSKEQFNEAQLALIRDIRRRGKNKVAAQNCRKRKLENIVELEQDLDHLKDEKEKLLKEKGENDKSLHLLKKQLSTLYLEV

--------------------------------------------------------------

>62972_62972_12_PAX8-NFE2L2_PAX8_chr2_113999128_ENST00000263335_NFE2L2_chr2_178097311_ENST00000397063_length(amino acids)=761AA_BP=290
MQPAGQGSGRRGPDLREEAPSPRRAASDSPAMPHNSIRSGHGGLNQLGGAFVNGRPLPEVVRQRIVDLAHQGVRPCDISRQLRVSHGCVS
KILGRYYETGSIRPGVIGGSKPKVATPKVVEKIGDYKRQNPTMFAWEIRDRLLAEGVCDNDTVPSVSSINRIIRTKVQQPFNLPMDSCVA
TKSLSPGHTLIPSSAVTPPESPQSDSLGSTYSINGLLGIAQPGSDKRKMDDSDQDSCRLSIDSQSSSSGPRKHLRTDAFSQHHLEPLECP
FERQHYPEAYASPSHTKGEQVSSATFQSLVPDIPGHIESPVFIATNQAQSPETSVAQVAPVDLDGMQQDIEQVWEELLSIPELQCLNIEN
DKLVETTMVPSPEAKLTEVDNYHFYSSIPSMEKEVGNCSPHFLNAFEDSFSSILSTEDPNQLTVNSLNSDATVNTDFGDEFYSAFIAEPS
ISNSMPSPATLSHSLSELLNGPIDVSDLSLCKAFNQNHPESTAEFNDSDSGISLNTSPSVASPEHSVESSSYGDTLLGLSDSEVEELDSA
PGSVKQNGPKTPVHSSGDMVQPLSPSQGQSTHVHDAQCENTPEKELPVSPGHRKTPFTKDKHSSRLEAHLTRDELRAKALHIPFPVEKII
NLPVVDFNEMMSKEQFNEAQLALIRDIRRRGKNKVAAQNCRKRKLENIVELEQDLDHLKDEKEKLLKEKGENDKSLHLLKKQLSTLYLEV

--------------------------------------------------------------

>62972_62972_13_PAX8-NFE2L2_PAX8_chr2_113999128_ENST00000348715_NFE2L2_chr2_178097311_ENST00000397062_length(amino acids)=761AA_BP=290
MQPAGQGSGRRGPDLREEAPSPRRAASDSPAMPHNSIRSGHGGLNQLGGAFVNGRPLPEVVRQRIVDLAHQGVRPCDISRQLRVSHGCVS
KILGRYYETGSIRPGVIGGSKPKVATPKVVEKIGDYKRQNPTMFAWEIRDRLLAEGVCDNDTVPSVSSINRIIRTKVQQPFNLPMDSCVA
TKSLSPGHTLIPSSAVTPPESPQSDSLGSTYSINGLLGIAQPGSDKRKMDDSDQDSCRLSIDSQSSSSGPRKHLRTDAFSQHHLEPLECP
FERQHYPEAYASPSHTKGEQVSSATFQSLVPDIPGHIESPVFIATNQAQSPETSVAQVAPVDLDGMQQDIEQVWEELLSIPELQCLNIEN
DKLVETTMVPSPEAKLTEVDNYHFYSSIPSMEKEVGNCSPHFLNAFEDSFSSILSTEDPNQLTVNSLNSDATVNTDFGDEFYSAFIAEPS
ISNSMPSPATLSHSLSELLNGPIDVSDLSLCKAFNQNHPESTAEFNDSDSGISLNTSPSVASPEHSVESSSYGDTLLGLSDSEVEELDSA
PGSVKQNGPKTPVHSSGDMVQPLSPSQGQSTHVHDAQCENTPEKELPVSPGHRKTPFTKDKHSSRLEAHLTRDELRAKALHIPFPVEKII
NLPVVDFNEMMSKEQFNEAQLALIRDIRRRGKNKVAAQNCRKRKLENIVELEQDLDHLKDEKEKLLKEKGENDKSLHLLKKQLSTLYLEV

--------------------------------------------------------------

>62972_62972_14_PAX8-NFE2L2_PAX8_chr2_113999128_ENST00000348715_NFE2L2_chr2_178097311_ENST00000397063_length(amino acids)=761AA_BP=290
MQPAGQGSGRRGPDLREEAPSPRRAASDSPAMPHNSIRSGHGGLNQLGGAFVNGRPLPEVVRQRIVDLAHQGVRPCDISRQLRVSHGCVS
KILGRYYETGSIRPGVIGGSKPKVATPKVVEKIGDYKRQNPTMFAWEIRDRLLAEGVCDNDTVPSVSSINRIIRTKVQQPFNLPMDSCVA
TKSLSPGHTLIPSSAVTPPESPQSDSLGSTYSINGLLGIAQPGSDKRKMDDSDQDSCRLSIDSQSSSSGPRKHLRTDAFSQHHLEPLECP
FERQHYPEAYASPSHTKGEQVSSATFQSLVPDIPGHIESPVFIATNQAQSPETSVAQVAPVDLDGMQQDIEQVWEELLSIPELQCLNIEN
DKLVETTMVPSPEAKLTEVDNYHFYSSIPSMEKEVGNCSPHFLNAFEDSFSSILSTEDPNQLTVNSLNSDATVNTDFGDEFYSAFIAEPS
ISNSMPSPATLSHSLSELLNGPIDVSDLSLCKAFNQNHPESTAEFNDSDSGISLNTSPSVASPEHSVESSSYGDTLLGLSDSEVEELDSA
PGSVKQNGPKTPVHSSGDMVQPLSPSQGQSTHVHDAQCENTPEKELPVSPGHRKTPFTKDKHSSRLEAHLTRDELRAKALHIPFPVEKII
NLPVVDFNEMMSKEQFNEAQLALIRDIRRRGKNKVAAQNCRKRKLENIVELEQDLDHLKDEKEKLLKEKGENDKSLHLLKKQLSTLYLEV

--------------------------------------------------------------

>62972_62972_15_PAX8-NFE2L2_PAX8_chr2_113999128_ENST00000397647_NFE2L2_chr2_178097311_ENST00000397062_length(amino acids)=761AA_BP=290
MQPAGQGSGRRGPDLREEAPSPRRAASDSPAMPHNSIRSGHGGLNQLGGAFVNGRPLPEVVRQRIVDLAHQGVRPCDISRQLRVSHGCVS
KILGRYYETGSIRPGVIGGSKPKVATPKVVEKIGDYKRQNPTMFAWEIRDRLLAEGVCDNDTVPSVSSINRIIRTKVQQPFNLPMDSCVA
TKSLSPGHTLIPSSAVTPPESPQSDSLGSTYSINGLLGIAQPGSDKRKMDDSDQDSCRLSIDSQSSSSGPRKHLRTDAFSQHHLEPLECP
FERQHYPEAYASPSHTKGEQVSSATFQSLVPDIPGHIESPVFIATNQAQSPETSVAQVAPVDLDGMQQDIEQVWEELLSIPELQCLNIEN
DKLVETTMVPSPEAKLTEVDNYHFYSSIPSMEKEVGNCSPHFLNAFEDSFSSILSTEDPNQLTVNSLNSDATVNTDFGDEFYSAFIAEPS
ISNSMPSPATLSHSLSELLNGPIDVSDLSLCKAFNQNHPESTAEFNDSDSGISLNTSPSVASPEHSVESSSYGDTLLGLSDSEVEELDSA
PGSVKQNGPKTPVHSSGDMVQPLSPSQGQSTHVHDAQCENTPEKELPVSPGHRKTPFTKDKHSSRLEAHLTRDELRAKALHIPFPVEKII
NLPVVDFNEMMSKEQFNEAQLALIRDIRRRGKNKVAAQNCRKRKLENIVELEQDLDHLKDEKEKLLKEKGENDKSLHLLKKQLSTLYLEV

--------------------------------------------------------------

>62972_62972_16_PAX8-NFE2L2_PAX8_chr2_113999128_ENST00000397647_NFE2L2_chr2_178097311_ENST00000397063_length(amino acids)=761AA_BP=290
MQPAGQGSGRRGPDLREEAPSPRRAASDSPAMPHNSIRSGHGGLNQLGGAFVNGRPLPEVVRQRIVDLAHQGVRPCDISRQLRVSHGCVS
KILGRYYETGSIRPGVIGGSKPKVATPKVVEKIGDYKRQNPTMFAWEIRDRLLAEGVCDNDTVPSVSSINRIIRTKVQQPFNLPMDSCVA
TKSLSPGHTLIPSSAVTPPESPQSDSLGSTYSINGLLGIAQPGSDKRKMDDSDQDSCRLSIDSQSSSSGPRKHLRTDAFSQHHLEPLECP
FERQHYPEAYASPSHTKGEQVSSATFQSLVPDIPGHIESPVFIATNQAQSPETSVAQVAPVDLDGMQQDIEQVWEELLSIPELQCLNIEN
DKLVETTMVPSPEAKLTEVDNYHFYSSIPSMEKEVGNCSPHFLNAFEDSFSSILSTEDPNQLTVNSLNSDATVNTDFGDEFYSAFIAEPS
ISNSMPSPATLSHSLSELLNGPIDVSDLSLCKAFNQNHPESTAEFNDSDSGISLNTSPSVASPEHSVESSSYGDTLLGLSDSEVEELDSA
PGSVKQNGPKTPVHSSGDMVQPLSPSQGQSTHVHDAQCENTPEKELPVSPGHRKTPFTKDKHSSRLEAHLTRDELRAKALHIPFPVEKII
NLPVVDFNEMMSKEQFNEAQLALIRDIRRRGKNKVAAQNCRKRKLENIVELEQDLDHLKDEKEKLLKEKGENDKSLHLLKKQLSTLYLEV

--------------------------------------------------------------

Top

Fusion Protein Functional Features

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr2:113999128/chr2:178097311)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
PAX8 Q06710	NFE2L2 Q16236
FUNCTION: Transcription factor for the thyroid-specific expression of the genes exclusively expressed in the thyroid cell type, maintaining the functional differentiation of such cells.	FUNCTION: Transcription factor that plays a key role in the response to oxidative stress: binds to antioxidant response (ARE) elements present in the promoter region of many cytoprotective genes, such as phase 2 detoxifying enzymes, and promotes their expression, thereby neutralizing reactive electrophiles (PubMed:11035812, PubMed:19489739, PubMed:29018201, PubMed:31398338). In normal conditions, ubiquitinated and degraded in the cytoplasm by the BCR(KEAP1) complex (PubMed:11035812, PubMed:15601839, PubMed:29018201). In response to oxidative stress, electrophile metabolites inhibit activity of the BCR(KEAP1) complex, promoting nuclear accumulation of NFE2L2/NRF2, heterodimerization with one of the small Maf proteins and binding to ARE elements of cytoprotective target genes (PubMed:19489739, PubMed:29590092). The NFE2L2/NRF2 pathway is also activated in response to selective autophagy: autophagy promotes interaction between KEAP1 and SQSTM1/p62 and subsequent inactivation of the BCR(KEAP1) complex, leading to NFE2L2/NRF2 nuclear accumulation and expression of cytoprotective genes (PubMed:20452972). May also be involved in the transcriptional activation of genes of the beta-globin cluster by mediating enhancer activity of hypersensitive site 2 of the beta-globin locus control region (PubMed:7937919). {ECO:0000269\|PubMed:11035812, ECO:0000269\|PubMed:15601839, ECO:0000269\|PubMed:19489739, ECO:0000269\|PubMed:20452972, ECO:0000269\|PubMed:29018201, ECO:0000269\|PubMed:29590092, ECO:0000269\|PubMed:31398338, ECO:0000269\|PubMed:7937919}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
* Minus value of BPloci means that the break pointn is located before the CDS.

- Retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

PAX8

chr2:113999127

chr2:178097311

ENST00000263334

9_135

259.0

399.0

DNA binding

Paired

Hgene

PAX8

chr2:113999127

chr2:178097311

ENST00000263335

9_135

259.0

1161.6666666666667

DNA binding

Paired

Hgene

PAX8

chr2:113999127

chr2:178097311

ENST00000348715

9_135

259.0

1238.6666666666667

DNA binding

Paired

Hgene

PAX8

chr2:113999127

chr2:178097311

ENST00000397647

9_135

259.0

1127.6666666666667

DNA binding

Paired

Hgene

PAX8

chr2:113999127

chr2:178097311

ENST00000429538

9_135

259.0

451.0

DNA binding

Paired

Hgene

PAX8

chr2:113999128

chr2:178097311

ENST00000263334

9_135

259.0

399.0

DNA binding

Paired

Hgene

PAX8

chr2:113999128

chr2:178097311

ENST00000263335

9_135

259.0

1161.6666666666667

DNA binding

Paired

Hgene

PAX8

chr2:113999128

chr2:178097311

ENST00000348715

9_135

259.0

1238.6666666666667

DNA binding

Paired

Hgene

PAX8

chr2:113999128

chr2:178097311

ENST00000397647

9_135

259.0

1127.6666666666667

DNA binding

Paired

Hgene

PAX8

chr2:113999128

chr2:178097311

ENST00000429538

9_135

259.0

451.0

DNA binding

Paired

Hgene

PAX8

chr2:113999127

chr2:178097311

ENST00000263334

12_68

259.0

399.0

Region

PAI subdomain

Hgene

PAX8

chr2:113999127

chr2:178097311

ENST00000263334

87_135

259.0

399.0

Region

RED subdomain

Hgene

PAX8

chr2:113999127

chr2:178097311

ENST00000263335

12_68

259.0

1161.6666666666667

Region

PAI subdomain

Hgene

PAX8

chr2:113999127

chr2:178097311

ENST00000263335

87_135

259.0

1161.6666666666667

Region

RED subdomain

Hgene

PAX8

chr2:113999127

chr2:178097311

ENST00000348715

12_68

259.0

1238.6666666666667

Region

PAI subdomain

Hgene

PAX8

chr2:113999127

chr2:178097311

ENST00000348715

87_135

259.0

1238.6666666666667

Region

RED subdomain

Hgene

PAX8

chr2:113999127

chr2:178097311

ENST00000397647

12_68

259.0

1127.6666666666667

Region

PAI subdomain

Hgene

PAX8

chr2:113999127

chr2:178097311

ENST00000397647

87_135

259.0

1127.6666666666667

Region

RED subdomain

Hgene

PAX8

chr2:113999127

chr2:178097311

ENST00000429538

12_68

259.0

451.0

Region

PAI subdomain

Hgene

PAX8

chr2:113999127

chr2:178097311

ENST00000429538

87_135

259.0

451.0

Region

RED subdomain

Hgene

PAX8

chr2:113999128

chr2:178097311

ENST00000263334

12_68

259.0

399.0

Region

PAI subdomain

Hgene

PAX8

chr2:113999128

chr2:178097311

ENST00000263334

87_135

259.0

399.0

Region

RED subdomain

Hgene

PAX8

chr2:113999128

chr2:178097311

ENST00000263335

12_68

259.0

1161.6666666666667

Region

PAI subdomain

Hgene

PAX8

chr2:113999128

chr2:178097311

ENST00000263335

87_135

259.0

1161.6666666666667

Region

RED subdomain

Hgene

PAX8

chr2:113999128

chr2:178097311

ENST00000348715

12_68

259.0

1238.6666666666667

Region

PAI subdomain

Hgene

PAX8

chr2:113999128

chr2:178097311

ENST00000348715

87_135

259.0

1238.6666666666667

Region

RED subdomain

Hgene

PAX8

chr2:113999128

chr2:178097311

ENST00000397647

12_68

259.0

1127.6666666666667

Region

PAI subdomain

Hgene

PAX8

chr2:113999128

chr2:178097311

ENST00000397647

87_135

259.0

1127.6666666666667

Region

RED subdomain

Hgene

PAX8

chr2:113999128

chr2:178097311

ENST00000429538

12_68

259.0

451.0

Region

PAI subdomain

Hgene

PAX8

chr2:113999128

chr2:178097311

ENST00000429538

87_135

259.0

451.0

Region

RED subdomain

Tgene

NFE2L2

chr2:113999127

chr2:178097311

ENST00000397062

497_560

134.0

606.0

Domain

bZIP

Tgene

NFE2L2

chr2:113999127

chr2:178097311

ENST00000397063

497_560

118.0

590.0

Domain

bZIP

Tgene

NFE2L2

chr2:113999127

chr2:178097311

ENST00000446151

497_560

583.0

Domain

bZIP

Tgene

NFE2L2

chr2:113999127

chr2:178097311

ENST00000464747

497_560

118.0

590.0

Domain

bZIP

Tgene

NFE2L2

chr2:113999128

chr2:178097311

ENST00000397062

497_560

134.0

606.0

Domain

bZIP

Tgene

NFE2L2

chr2:113999128

chr2:178097311

ENST00000397063

497_560

118.0

590.0

Domain

bZIP

Tgene

NFE2L2

chr2:113999128

chr2:178097311

ENST00000446151

497_560

583.0

Domain

bZIP

Tgene

NFE2L2

chr2:113999128

chr2:178097311

ENST00000464747

497_560

118.0

590.0

Domain

bZIP

Tgene

NFE2L2

chr2:113999127

chr2:178097311

ENST00000446151

29_31

583.0

Motif

DLG motif

Tgene

NFE2L2

chr2:113999128

chr2:178097311

ENST00000446151

29_31

583.0

Motif

DLG motif

Tgene

NFE2L2

chr2:113999127

chr2:178097311

ENST00000397062

499_518

134.0

606.0

Region

Basic motif

Tgene

NFE2L2

chr2:113999127

chr2:178097311

ENST00000397062

522_529

134.0

606.0

Region

Leucine-zipper

Tgene

NFE2L2

chr2:113999127

chr2:178097311

ENST00000397063

499_518

118.0

590.0

Region

Basic motif

Tgene

NFE2L2

chr2:113999127

chr2:178097311

ENST00000397063

522_529

118.0

590.0

Region

Leucine-zipper

Tgene

NFE2L2

chr2:113999127

chr2:178097311

ENST00000446151

499_518

583.0

Region

Basic motif

Tgene

NFE2L2

chr2:113999127

chr2:178097311

ENST00000446151

522_529

583.0

Region

Leucine-zipper

Tgene

NFE2L2

chr2:113999127

chr2:178097311

ENST00000464747

499_518

118.0

590.0

Region

Basic motif

Tgene

NFE2L2

chr2:113999127

chr2:178097311

ENST00000464747

522_529

118.0

590.0

Region

Leucine-zipper

Tgene

NFE2L2

chr2:113999128

chr2:178097311

ENST00000397062

499_518

134.0

606.0

Region

Basic motif

Tgene

NFE2L2

chr2:113999128

chr2:178097311

ENST00000397062

522_529

134.0

606.0

Region

Leucine-zipper

Tgene

NFE2L2

chr2:113999128

chr2:178097311

ENST00000397063

499_518

118.0

590.0

Region

Basic motif

Tgene

NFE2L2

chr2:113999128

chr2:178097311

ENST00000397063

522_529

118.0

590.0

Region

Leucine-zipper

Tgene

NFE2L2

chr2:113999128

chr2:178097311

ENST00000446151

499_518

583.0

Region

Basic motif

Tgene

NFE2L2

chr2:113999128

chr2:178097311

ENST00000446151

522_529

583.0

Region

Leucine-zipper

Tgene

NFE2L2

chr2:113999128

chr2:178097311

ENST00000464747

499_518

118.0

590.0

Region

Basic motif

Tgene

NFE2L2

chr2:113999128

chr2:178097311

ENST00000464747

522_529

118.0

590.0

Region

Leucine-zipper

- Not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

PAX8

chr2:113999127

chr2:178097311

ENST00000263334

315_327

259.0

399.0

Compositional bias

Note=Ser-rich

Hgene

PAX8

chr2:113999127

chr2:178097311

ENST00000263335

315_327

259.0

1161.6666666666667

Compositional bias

Note=Ser-rich

Hgene

PAX8

chr2:113999127

chr2:178097311

ENST00000348715

315_327

259.0

1238.6666666666667

Compositional bias

Note=Ser-rich

Hgene

PAX8

chr2:113999127

chr2:178097311

ENST00000397647

315_327

259.0

1127.6666666666667

Compositional bias

Note=Ser-rich

Hgene

PAX8

chr2:113999127

chr2:178097311

ENST00000429538

315_327

259.0

451.0

Compositional bias

Note=Ser-rich

Hgene

PAX8

chr2:113999128

chr2:178097311

ENST00000263334

315_327

259.0

399.0

Compositional bias

Note=Ser-rich

Hgene

PAX8

chr2:113999128

chr2:178097311

ENST00000263335

315_327

259.0

1161.6666666666667

Compositional bias

Note=Ser-rich

Hgene

PAX8

chr2:113999128

chr2:178097311

ENST00000348715

315_327

259.0

1238.6666666666667

Compositional bias

Note=Ser-rich

Hgene

PAX8

chr2:113999128

chr2:178097311

ENST00000397647

315_327

259.0

1127.6666666666667

Compositional bias

Note=Ser-rich

Hgene

PAX8

chr2:113999128

chr2:178097311

ENST00000429538

315_327

259.0

451.0

Compositional bias

Note=Ser-rich

Tgene

NFE2L2

chr2:113999127

chr2:178097311

ENST00000397062

29_31

134.0

606.0

Motif

DLG motif

Tgene

NFE2L2

chr2:113999127

chr2:178097311

ENST00000397063

29_31

118.0

590.0

Motif

DLG motif

Tgene

NFE2L2

chr2:113999127

chr2:178097311

ENST00000464747

29_31

118.0

590.0

Motif

DLG motif

Tgene

NFE2L2

chr2:113999128

chr2:178097311

ENST00000397062

29_31

134.0

606.0

Motif

DLG motif

Tgene

NFE2L2

chr2:113999128

chr2:178097311

ENST00000397063

29_31

118.0

590.0

Motif

DLG motif

Tgene

NFE2L2

chr2:113999128

chr2:178097311

ENST00000464747

29_31

118.0

590.0

Motif

DLG motif

Top

Fusion Protein-Protein Interaction

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)

Gene

PPI interactors

Protein-protein interactors based on sequence similarity (STRING)

Gene	STRING network
PAX8
NFE2L2

- Retained interactions in fusion protein (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost interactions due to fusion (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs to PAX8-NFE2L2

Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Drug

Source

PMID

Top

Related Diseases to PAX8-NFE2L2

Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Disease

Source

PMID

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner	Gene	Disease ID	Disease name	# pubmeds	Source
Hgene	PAX8	C0151516	Thyroid Hypoplasia	4	GENOMICS_ENGLAND;ORPHANET
Hgene	PAX8	C0238463	Papillary thyroid carcinoma	4	ORPHANET
Hgene	PAX8	C1869118	HYPOTHYROIDISM, CONGENITAL, DUE TO THYROID DYSGENESIS	3	CTD_human;GENOMICS_ENGLAND;UNIPROT
Hgene	PAX8	C0009402	Colorectal Carcinoma	1	CTD_human
Hgene	PAX8	C0009404	Colorectal Neoplasms	1	CTD_human
Hgene	PAX8	C0010308	Congenital Hypothyroidism	1	GENOMICS_ENGLAND
Hgene	PAX8	C0266283	Ectopic thyroid tissue (disorder)	1	ORPHANET
Hgene	PAX8	C1563716	Thyroid Dysgenesis	1	GENOMICS_ENGLAND
Hgene	PAX8	C2931367	Thyroid cancer, follicular	1	CTD_human