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Center for Computational Systems Medicine level1
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:PBRM1-FBXW12

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: PBRM1-FBXW12
FusionPDB ID: 63000
FusionGDB2.0 ID: 63000
HgeneTgene
Gene symbol

PBRM1

FBXW12

Gene ID

55193

285231

Gene namepolybromo 1F-box and WD repeat domain containing 12
SynonymsBAF180|PB1FBW12|FBXO12|FBXO35
Cytomap

3p21.1

3p21.31

Type of geneprotein-codingprotein-coding
Descriptionprotein polybromo-1BRG1-associated factor 180polybromo-1DF-box/WD repeat-containing protein 12F-box and WD-40 domain protein 12F-box and WD-40 domain-containing protein 12F-box only protein 35F-box- and WD40-repeat-containing protein
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST idsENST00000296302, ENST00000337303, 
ENST00000356770, ENST00000394830, 
ENST00000409057, ENST00000409114, 
ENST00000409767, ENST00000410007, 
ENST00000436231, ENST00000468158, 
ENST00000296438, ENST00000415155, 
ENST00000445170, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score15 X 15 X 10=22505 X 5 X 5=125
# samples 198
** MAII scorelog2(19/2250*10)=-3.56585367777345
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(8/125*10)=-0.643856189774725
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: PBRM1 [Title/Abstract] AND FBXW12 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)PBRM1(52592265)-FBXW12(48416844), # samples:1
PBRM1(52595783)-FBXW12(48416844), # samples:1
Anticipated loss of major functional domain due to fusion event.PBRM1-FBXW12 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
PBRM1-FBXW12 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
PBRM1-FBXW12 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
PBRM1-FBXW12 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
PBRM1-FBXW12 seems lost the major protein functional domain in Hgene partner, which is a CGC due to the frame-shifted ORF.
PBRM1-FBXW12 seems lost the major protein functional domain in Hgene partner, which is a epigenetic factor due to the frame-shifted ORF.
PBRM1-FBXW12 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
PBRM1-FBXW12 seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
PBRM1-FBXW12 seems lost the major protein functional domain in Hgene partner, which is a tumor suppressor due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across PBRM1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across FBXW12 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4MESOTCGA-MQ-A4LM-01APBRM1chr3

52592265

-FBXW12chr3

48416844

+
ChimerDB4MESOTCGA-MQ-A4LM-01APBRM1chr3

52595783

-FBXW12chr3

48416844

+


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000296302PBRM1chr352592265-ENST00000296438FBXW12chr348416844+56304455255631853
ENST00000296302PBRM1chr352592265-ENST00000415155FBXW12chr348416844+53824455253531783
ENST00000296302PBRM1chr352592265-ENST00000445170FBXW12chr348416844+55924455255631853
ENST00000409114PBRM1chr352592265-ENST00000296438FBXW12chr348416844+56764501356091868
ENST00000409114PBRM1chr352592265-ENST00000415155FBXW12chr348416844+54284501353991798
ENST00000409114PBRM1chr352592265-ENST00000445170FBXW12chr348416844+56384501356091868
ENST00000356770PBRM1chr352595783-ENST00000296438FBXW12chr348416844+53704195353031766
ENST00000356770PBRM1chr352595783-ENST00000415155FBXW12chr348416844+51224195350931696
ENST00000356770PBRM1chr352595783-ENST00000445170FBXW12chr348416844+53324195353031766
ENST00000296302PBRM1chr352595783-ENST00000296438FBXW12chr348416844+54654290253981798
ENST00000296302PBRM1chr352595783-ENST00000415155FBXW12chr348416844+52174290251881728
ENST00000296302PBRM1chr352595783-ENST00000445170FBXW12chr348416844+54274290253981798
ENST00000337303PBRM1chr352595783-ENST00000296438FBXW12chr348416844+54664291353991798
ENST00000337303PBRM1chr352595783-ENST00000415155FBXW12chr348416844+52184291351891728
ENST00000337303PBRM1chr352595783-ENST00000445170FBXW12chr348416844+54284291353991798
ENST00000410007PBRM1chr352595783-ENST00000296438FBXW12chr348416844+53914216353241773
ENST00000410007PBRM1chr352595783-ENST00000415155FBXW12chr348416844+51434216351141703
ENST00000410007PBRM1chr352595783-ENST00000445170FBXW12chr348416844+53534216353241773
ENST00000409057PBRM1chr352595783-ENST00000296438FBXW12chr348416844+54664291353991798
ENST00000409057PBRM1chr352595783-ENST00000415155FBXW12chr348416844+52184291351891728
ENST00000409057PBRM1chr352595783-ENST00000445170FBXW12chr348416844+54284291353991798
ENST00000409114PBRM1chr352595783-ENST00000296438FBXW12chr348416844+55114336354441813
ENST00000409114PBRM1chr352595783-ENST00000415155FBXW12chr348416844+52634336352341743
ENST00000409114PBRM1chr352595783-ENST00000445170FBXW12chr348416844+54734336354441813
ENST00000409767PBRM1chr352595783-ENST00000296438FBXW12chr348416844+55114336354441813
ENST00000409767PBRM1chr352595783-ENST00000415155FBXW12chr348416844+52634336352341743
ENST00000409767PBRM1chr352595783-ENST00000445170FBXW12chr348416844+54734336354441813

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000296302ENST00000296438PBRM1chr352592265-FBXW12chr348416844+0.0008835890.99911636
ENST00000296302ENST00000415155PBRM1chr352592265-FBXW12chr348416844+0.0007955650.99920446
ENST00000296302ENST00000445170PBRM1chr352592265-FBXW12chr348416844+0.0008685130.9991315
ENST00000409114ENST00000296438PBRM1chr352592265-FBXW12chr348416844+0.0009221690.9990778
ENST00000409114ENST00000415155PBRM1chr352592265-FBXW12chr348416844+0.0008360430.999164
ENST00000409114ENST00000445170PBRM1chr352592265-FBXW12chr348416844+0.000906920.99909306
ENST00000356770ENST00000296438PBRM1chr352595783-FBXW12chr348416844+0.0006218720.9993781
ENST00000356770ENST00000415155PBRM1chr352595783-FBXW12chr348416844+0.000451410.9995486
ENST00000356770ENST00000445170PBRM1chr352595783-FBXW12chr348416844+0.0006090440.99939096
ENST00000296302ENST00000296438PBRM1chr352595783-FBXW12chr348416844+0.0006577880.99934214
ENST00000296302ENST00000415155PBRM1chr352595783-FBXW12chr348416844+0.0004759480.9995241
ENST00000296302ENST00000445170PBRM1chr352595783-FBXW12chr348416844+0.0006448160.99935514
ENST00000337303ENST00000296438PBRM1chr352595783-FBXW12chr348416844+0.0006630730.9993369
ENST00000337303ENST00000415155PBRM1chr352595783-FBXW12chr348416844+0.0004807610.9995192
ENST00000337303ENST00000445170PBRM1chr352595783-FBXW12chr348416844+0.0006500480.9993499
ENST00000410007ENST00000296438PBRM1chr352595783-FBXW12chr348416844+0.0005199460.99948007
ENST00000410007ENST00000415155PBRM1chr352595783-FBXW12chr348416844+0.000371260.99962866
ENST00000410007ENST00000445170PBRM1chr352595783-FBXW12chr348416844+0.0005061420.99949384
ENST00000409057ENST00000296438PBRM1chr352595783-FBXW12chr348416844+0.0006630730.9993369
ENST00000409057ENST00000415155PBRM1chr352595783-FBXW12chr348416844+0.0004807610.9995192
ENST00000409057ENST00000445170PBRM1chr352595783-FBXW12chr348416844+0.0006500480.9993499
ENST00000409114ENST00000296438PBRM1chr352595783-FBXW12chr348416844+0.0006820450.999318
ENST00000409114ENST00000415155PBRM1chr352595783-FBXW12chr348416844+0.0004950430.9995049
ENST00000409114ENST00000445170PBRM1chr352595783-FBXW12chr348416844+0.000667350.9993326
ENST00000409767ENST00000296438PBRM1chr352595783-FBXW12chr348416844+0.0006820450.999318
ENST00000409767ENST00000415155PBRM1chr352595783-FBXW12chr348416844+0.0004950430.9995049
ENST00000409767ENST00000445170PBRM1chr352595783-FBXW12chr348416844+0.000667350.9993326

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>63000_63000_1_PBRM1-FBXW12_PBRM1_chr3_52592265_ENST00000296302_FBXW12_chr3_48416844_ENST00000296438_length(amino acids)=1853AA_BP=1484
MGSKRRRATSPSSSVSGDFDDGHHSVSTPGPSRKRRRLSNLPTVDPIAVCHELYNTIRDYKDEQGRLLCELFIRAPKRRNQPDYYEVVSQ
PIDLMKIQQKLKMEEYDDVNLLTADFQLLFNNAKSYYKPDSPEYKAACKLWDLYLRTRNEFVQKGEADDEDDDEDGQDNQGTVTEGSSPA
YLKEILEQLLEAIVVATNPSGRLISELFQKLPSKVQYPDYYAIIKEPIDLKTIAQRIQNGSYKSIHAMAKDIDLLAKNAKTYNEPGSQVF
KDANSIKKIFYMKKAEIEHHEMAKSSLRMRTPSNLAAARLTGPSHSKGSLGEERNPTSKYYRNKRAVQGGRLSAITMALQYGSESEEDAA
LAAARYEEGESEAESITSFMDVSNPFYQLYDTVRSCRNNQGQLIAEPFYHLPSKKKYPDYYQQIKMPISLQQIRTKLKNQEYETLDHLEC
DLNLMFENAKRYNVPNSAIYKRVLKLQQVMQAKKKELARRDDIEDGDSMISSATSDTGSAKRKSKKNIRKQRMKILFNVVLEAREPGSGR
RLCDLFMVKPSKKDYPDYYKIILEPMDLKIIEHNIRNDKYAGEEGMIEDMKLMFRNARHYNEEGSQVYNDAHILEKLLKEKRKELGPLPD
DDDMASPKLKLSRKSGISPKKSKYMTPMQQKLNEVYEAVKNYTDKRGRRLSAIFLRLPSRSELPDYYLTIKKPMDMEKIRSHMMANKYQD
IDSMVEDFVMMFNNACTYNEPESLIYKDALVLHKVLLETRRDLEGDEDSHVPNVTLLIQELIHNLFVSVMSHQDDEGRCYSDSLAEIPAV
DPNFPNKPPLTFDIIRKNVENNRYRRLDLFQEHMFEVLERARRMNRTDSEIYEDAVELQQFFIKIRDELCKNGEILLSPALSYTTKHLHN
DVEKERKEKLPKEIEEDKLKREEEKREAEKSEDSSGAAGLSGLHRTYSQDCSFKNSMYHVGDYVYVEPAEANLQPHIVCIERLWEDSAGE
KWLYGCWFYRPNETFHLATRKFLEKEVFKSDYYNKVPVSKILGKCVVMFVKEYFKLCPENFRDEDVFVCESRYSAKTKSFKKIKLWTMPI
SSVRFVPRDVPLPVVRVASVFANADKGDDEKNTDNSEDSRAEDNFNLEKEKEDVPVEMSNGEPGCHYFEQLHYNDMWLKVGDCVFIKSHG
LVRPRVGRIEKVWVRDGAAYFYGPIFIHPEETEHEPTKMFYKKEVFLSNLEETCPMTCILGKCAVLSFKDFLSCRPTEIPENDILLCESR
YNESDKQMKKFKGLKRFSLSAKVVDDEIYYFRKPIVPQKEPSPLLEKKIQLLEAKFAELEGGDDDIEEMGEEDSEVIEPPSLPQLQTPLA
SELDLMPYTPPQSTPKSAKGSAKKEGSKRKINMSGYILFSSEMRAVIKAQHPDYSFGELSRLVGTEWRNLETAKKAEYEERAAKVAEQQE
RERAAQQQQPSASPRAGTPVGALMGVVPPPTPMGMLNQQLTPVAAFETELAYLSGNRLTVDEQEKSIICSVSPKQELCAWDVQEGTMIWS
SPVQEFHFSNLVTLPQMHLAITMDRKKTIKVWNCQDRDALAVLPMPQPCYCMEAYLTKDGPFLMVGDAAGDIYTFTLPGLRDVSKVTAFQ
YGIVLLHCSPDKKWVFACGTYSRTLPQVFLTESLLRPSEGSVPLSTFLPHKLCASACWTPKVKNRITLMSQSSTGKKTEFITFDLTTKKT
GGQTVIQAYEIASFQVAAHLKCPIWMGASDGYMIVFTSGPYLLLFSITGFLLQRFEDHQAAINNFWVDPCYVLTTSENSVHVYMWEEGGR

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>63000_63000_2_PBRM1-FBXW12_PBRM1_chr3_52592265_ENST00000296302_FBXW12_chr3_48416844_ENST00000415155_length(amino acids)=1783AA_BP=1484
MGSKRRRATSPSSSVSGDFDDGHHSVSTPGPSRKRRRLSNLPTVDPIAVCHELYNTIRDYKDEQGRLLCELFIRAPKRRNQPDYYEVVSQ
PIDLMKIQQKLKMEEYDDVNLLTADFQLLFNNAKSYYKPDSPEYKAACKLWDLYLRTRNEFVQKGEADDEDDDEDGQDNQGTVTEGSSPA
YLKEILEQLLEAIVVATNPSGRLISELFQKLPSKVQYPDYYAIIKEPIDLKTIAQRIQNGSYKSIHAMAKDIDLLAKNAKTYNEPGSQVF
KDANSIKKIFYMKKAEIEHHEMAKSSLRMRTPSNLAAARLTGPSHSKGSLGEERNPTSKYYRNKRAVQGGRLSAITMALQYGSESEEDAA
LAAARYEEGESEAESITSFMDVSNPFYQLYDTVRSCRNNQGQLIAEPFYHLPSKKKYPDYYQQIKMPISLQQIRTKLKNQEYETLDHLEC
DLNLMFENAKRYNVPNSAIYKRVLKLQQVMQAKKKELARRDDIEDGDSMISSATSDTGSAKRKSKKNIRKQRMKILFNVVLEAREPGSGR
RLCDLFMVKPSKKDYPDYYKIILEPMDLKIIEHNIRNDKYAGEEGMIEDMKLMFRNARHYNEEGSQVYNDAHILEKLLKEKRKELGPLPD
DDDMASPKLKLSRKSGISPKKSKYMTPMQQKLNEVYEAVKNYTDKRGRRLSAIFLRLPSRSELPDYYLTIKKPMDMEKIRSHMMANKYQD
IDSMVEDFVMMFNNACTYNEPESLIYKDALVLHKVLLETRRDLEGDEDSHVPNVTLLIQELIHNLFVSVMSHQDDEGRCYSDSLAEIPAV
DPNFPNKPPLTFDIIRKNVENNRYRRLDLFQEHMFEVLERARRMNRTDSEIYEDAVELQQFFIKIRDELCKNGEILLSPALSYTTKHLHN
DVEKERKEKLPKEIEEDKLKREEEKREAEKSEDSSGAAGLSGLHRTYSQDCSFKNSMYHVGDYVYVEPAEANLQPHIVCIERLWEDSAGE
KWLYGCWFYRPNETFHLATRKFLEKEVFKSDYYNKVPVSKILGKCVVMFVKEYFKLCPENFRDEDVFVCESRYSAKTKSFKKIKLWTMPI
SSVRFVPRDVPLPVVRVASVFANADKGDDEKNTDNSEDSRAEDNFNLEKEKEDVPVEMSNGEPGCHYFEQLHYNDMWLKVGDCVFIKSHG
LVRPRVGRIEKVWVRDGAAYFYGPIFIHPEETEHEPTKMFYKKEVFLSNLEETCPMTCILGKCAVLSFKDFLSCRPTEIPENDILLCESR
YNESDKQMKKFKGLKRFSLSAKVVDDEIYYFRKPIVPQKEPSPLLEKKIQLLEAKFAELEGGDDDIEEMGEEDSEVIEPPSLPQLQTPLA
SELDLMPYTPPQSTPKSAKGSAKKEGSKRKINMSGYILFSSEMRAVIKAQHPDYSFGELSRLVGTEWRNLETAKKAEYEERAAKVAEQQE
RERAAQQQQPSASPRAGTPVGALMGVVPPPTPMGMLNQQLTPVAAFETELAYLSGNRLTVDEQEKSIICSVSPKQELCAWDVQEVGDAAG
DIYTFTLPGLRDVSKVTAFQYGIVLLHCSPDKKWVFACGTYSRTLPQVFLTESLLRPSEGSVPLSTFLPHKLCASACWTPKVKNRITLMS
QSSTGKKTEFITFDLTTKKTGGQTVIQAYEIASFQVAAHLKCPIWMGASDGYMIVFTSGPYLLLFSITGFLLQRFEDHQAAINNFWVDPC

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>63000_63000_3_PBRM1-FBXW12_PBRM1_chr3_52592265_ENST00000296302_FBXW12_chr3_48416844_ENST00000445170_length(amino acids)=1853AA_BP=1484
MGSKRRRATSPSSSVSGDFDDGHHSVSTPGPSRKRRRLSNLPTVDPIAVCHELYNTIRDYKDEQGRLLCELFIRAPKRRNQPDYYEVVSQ
PIDLMKIQQKLKMEEYDDVNLLTADFQLLFNNAKSYYKPDSPEYKAACKLWDLYLRTRNEFVQKGEADDEDDDEDGQDNQGTVTEGSSPA
YLKEILEQLLEAIVVATNPSGRLISELFQKLPSKVQYPDYYAIIKEPIDLKTIAQRIQNGSYKSIHAMAKDIDLLAKNAKTYNEPGSQVF
KDANSIKKIFYMKKAEIEHHEMAKSSLRMRTPSNLAAARLTGPSHSKGSLGEERNPTSKYYRNKRAVQGGRLSAITMALQYGSESEEDAA
LAAARYEEGESEAESITSFMDVSNPFYQLYDTVRSCRNNQGQLIAEPFYHLPSKKKYPDYYQQIKMPISLQQIRTKLKNQEYETLDHLEC
DLNLMFENAKRYNVPNSAIYKRVLKLQQVMQAKKKELARRDDIEDGDSMISSATSDTGSAKRKSKKNIRKQRMKILFNVVLEAREPGSGR
RLCDLFMVKPSKKDYPDYYKIILEPMDLKIIEHNIRNDKYAGEEGMIEDMKLMFRNARHYNEEGSQVYNDAHILEKLLKEKRKELGPLPD
DDDMASPKLKLSRKSGISPKKSKYMTPMQQKLNEVYEAVKNYTDKRGRRLSAIFLRLPSRSELPDYYLTIKKPMDMEKIRSHMMANKYQD
IDSMVEDFVMMFNNACTYNEPESLIYKDALVLHKVLLETRRDLEGDEDSHVPNVTLLIQELIHNLFVSVMSHQDDEGRCYSDSLAEIPAV
DPNFPNKPPLTFDIIRKNVENNRYRRLDLFQEHMFEVLERARRMNRTDSEIYEDAVELQQFFIKIRDELCKNGEILLSPALSYTTKHLHN
DVEKERKEKLPKEIEEDKLKREEEKREAEKSEDSSGAAGLSGLHRTYSQDCSFKNSMYHVGDYVYVEPAEANLQPHIVCIERLWEDSAGE
KWLYGCWFYRPNETFHLATRKFLEKEVFKSDYYNKVPVSKILGKCVVMFVKEYFKLCPENFRDEDVFVCESRYSAKTKSFKKIKLWTMPI
SSVRFVPRDVPLPVVRVASVFANADKGDDEKNTDNSEDSRAEDNFNLEKEKEDVPVEMSNGEPGCHYFEQLHYNDMWLKVGDCVFIKSHG
LVRPRVGRIEKVWVRDGAAYFYGPIFIHPEETEHEPTKMFYKKEVFLSNLEETCPMTCILGKCAVLSFKDFLSCRPTEIPENDILLCESR
YNESDKQMKKFKGLKRFSLSAKVVDDEIYYFRKPIVPQKEPSPLLEKKIQLLEAKFAELEGGDDDIEEMGEEDSEVIEPPSLPQLQTPLA
SELDLMPYTPPQSTPKSAKGSAKKEGSKRKINMSGYILFSSEMRAVIKAQHPDYSFGELSRLVGTEWRNLETAKKAEYEERAAKVAEQQE
RERAAQQQQPSASPRAGTPVGALMGVVPPPTPMGMLNQQLTPVAAFETELAYLSGNRLTVDEQEKSIICSVSPKQELCAWDVQEGTMIWS
SPVQEFHFSNLVTLPQMHLAITMDRKKTIKVWNCQDRDALAVLPMPQPCYCMEAYLTKDGPFLMVGDAAGDIYTFTLPGLRDVSKVTAFQ
YGIVLLHCSPDKKWVFACGTYSRTLPQVFLTESLLRPSEGSVPLSTFLPHKLCASACWTPKVKNRITLMSQSSTGKKTEFITFDLTTKKT
GGQTVIQAYEIASFQVAAHLKCPIWMGASDGYMIVFTSGPYLLLFSITGFLLQRFEDHQAAINNFWVDPCYVLTTSENSVHVYMWEEGGR

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>63000_63000_4_PBRM1-FBXW12_PBRM1_chr3_52592265_ENST00000409114_FBXW12_chr3_48416844_ENST00000296438_length(amino acids)=1868AA_BP=1499
MGSKRRRATSPSSSVSGDFDDGHHSVSTPGPSRKRRRLSNLPTVDPIAVCHELYNTIRDYKDEQGRLLCELFIRAPKRRNQPDYYEVVSQ
PIDLMKIQQKLKMEEYDDVNLLTADFQLLFNNAKSYYKPDSPEYKAACKLWDLYLRTRNEFVQKGEADDEDDDEDGQDNQGTVTEGSSPA
YLKEILEQLLEAIVVATNPSGRLISELFQKLPSKVQYPDYYAIIKEPIDLKTIAQRIQNGSYKSIHAMAKDIDLLAKNAKTYNEPGSQVF
KDANSIKKIFYMKKAEIEHHEMAKSSLRMRTPSNLAAARLTGPSHSKGSLGEERNPTSKYYRNKRAVQGGRLSAITMALQYGSESEEDAA
LAAARYEEGESEAESITSFMDVSNPFYQLYDTVRSCRNNQGQLIAEPFYHLPSKKKYPDYYQQIKMPISLQQIRTKLKNQEYETLDHLEC
DLNLMFENAKRYNVPNSAIYKRVLKLQQVMQAKKKELARRDDIEDGDSMISSATSDTGSAKRKRNTHDSEMLGLRRLSSKKNIRKQRMKI
LFNVVLEAREPGSGRRLCDLFMVKPSKKDYPDYYKIILEPMDLKIIEHNIRNDKYAGEEGMIEDMKLMFRNARHYNEEGSQVYNDAHILE
KLLKEKRKELGPLPDDDDMASPKLKLSRKSGISPKKSKYMTPMQQKLNEVYEAVKNYTDKRGRRLSAIFLRLPSRSELPDYYLTIKKPMD
MEKIRSHMMANKYQDIDSMVEDFVMMFNNACTYNEPESLIYKDALVLHKVLLETRRDLEGDEDSHVPNVTLLIQELIHNLFVSVMSHQDD
EGRCYSDSLAEIPAVDPNFPNKPPLTFDIIRKNVENNRYRRLDLFQEHMFEVLERARRMNRTDSEIYEDAVELQQFFIKIRDELCKNGEI
LLSPALSYTTKHLHNDVEKERKEKLPKEIEEDKLKREEEKREAEKSEDSSGAAGLSGLHRTYSQDCSFKNSMYHVGDYVYVEPAEANLQP
HIVCIERLWEDSAGEKWLYGCWFYRPNETFHLATRKFLEKEVFKSDYYNKVPVSKILGKCVVMFVKEYFKLCPENFRDEDVFVCESRYSA
KTKSFKKIKLWTMPISSVRFVPRDVPLPVVRVASVFANADKGDDEKNTDNSEDSRAEDNFNLEKEKEDVPVEMSNGEPGCHYFEQLHYND
MWLKVGDCVFIKSHGLVRPRVGRIEKVWVRDGAAYFYGPIFIHPEETEHEPTKMFYKKEVFLSNLEETCPMTCILGKCAVLSFKDFLSCR
PTEIPENDILLCESRYNESDKQMKKFKGLKRFSLSAKVVDDEIYYFRKPIVPQKEPSPLLEKKIQLLEAKFAELEGGDDDIEEMGEEDSE
VIEPPSLPQLQTPLASELDLMPYTPPQSTPKSAKGSAKKEGSKRKINMSGYILFSSEMRAVIKAQHPDYSFGELSRLVGTEWRNLETAKK
AEYEERAAKVAEQQERERAAQQQQPSASPRAGTPVGALMGVVPPPTPMGMLNQQLTPVAAFETELAYLSGNRLTVDEQEKSIICSVSPKQ
ELCAWDVQEGTMIWSSPVQEFHFSNLVTLPQMHLAITMDRKKTIKVWNCQDRDALAVLPMPQPCYCMEAYLTKDGPFLMVGDAAGDIYTF
TLPGLRDVSKVTAFQYGIVLLHCSPDKKWVFACGTYSRTLPQVFLTESLLRPSEGSVPLSTFLPHKLCASACWTPKVKNRITLMSQSSTG
KKTEFITFDLTTKKTGGQTVIQAYEIASFQVAAHLKCPIWMGASDGYMIVFTSGPYLLLFSITGFLLQRFEDHQAAINNFWVDPCYVLTT

--------------------------------------------------------------

>63000_63000_5_PBRM1-FBXW12_PBRM1_chr3_52592265_ENST00000409114_FBXW12_chr3_48416844_ENST00000415155_length(amino acids)=1798AA_BP=1499
MGSKRRRATSPSSSVSGDFDDGHHSVSTPGPSRKRRRLSNLPTVDPIAVCHELYNTIRDYKDEQGRLLCELFIRAPKRRNQPDYYEVVSQ
PIDLMKIQQKLKMEEYDDVNLLTADFQLLFNNAKSYYKPDSPEYKAACKLWDLYLRTRNEFVQKGEADDEDDDEDGQDNQGTVTEGSSPA
YLKEILEQLLEAIVVATNPSGRLISELFQKLPSKVQYPDYYAIIKEPIDLKTIAQRIQNGSYKSIHAMAKDIDLLAKNAKTYNEPGSQVF
KDANSIKKIFYMKKAEIEHHEMAKSSLRMRTPSNLAAARLTGPSHSKGSLGEERNPTSKYYRNKRAVQGGRLSAITMALQYGSESEEDAA
LAAARYEEGESEAESITSFMDVSNPFYQLYDTVRSCRNNQGQLIAEPFYHLPSKKKYPDYYQQIKMPISLQQIRTKLKNQEYETLDHLEC
DLNLMFENAKRYNVPNSAIYKRVLKLQQVMQAKKKELARRDDIEDGDSMISSATSDTGSAKRKRNTHDSEMLGLRRLSSKKNIRKQRMKI
LFNVVLEAREPGSGRRLCDLFMVKPSKKDYPDYYKIILEPMDLKIIEHNIRNDKYAGEEGMIEDMKLMFRNARHYNEEGSQVYNDAHILE
KLLKEKRKELGPLPDDDDMASPKLKLSRKSGISPKKSKYMTPMQQKLNEVYEAVKNYTDKRGRRLSAIFLRLPSRSELPDYYLTIKKPMD
MEKIRSHMMANKYQDIDSMVEDFVMMFNNACTYNEPESLIYKDALVLHKVLLETRRDLEGDEDSHVPNVTLLIQELIHNLFVSVMSHQDD
EGRCYSDSLAEIPAVDPNFPNKPPLTFDIIRKNVENNRYRRLDLFQEHMFEVLERARRMNRTDSEIYEDAVELQQFFIKIRDELCKNGEI
LLSPALSYTTKHLHNDVEKERKEKLPKEIEEDKLKREEEKREAEKSEDSSGAAGLSGLHRTYSQDCSFKNSMYHVGDYVYVEPAEANLQP
HIVCIERLWEDSAGEKWLYGCWFYRPNETFHLATRKFLEKEVFKSDYYNKVPVSKILGKCVVMFVKEYFKLCPENFRDEDVFVCESRYSA
KTKSFKKIKLWTMPISSVRFVPRDVPLPVVRVASVFANADKGDDEKNTDNSEDSRAEDNFNLEKEKEDVPVEMSNGEPGCHYFEQLHYND
MWLKVGDCVFIKSHGLVRPRVGRIEKVWVRDGAAYFYGPIFIHPEETEHEPTKMFYKKEVFLSNLEETCPMTCILGKCAVLSFKDFLSCR
PTEIPENDILLCESRYNESDKQMKKFKGLKRFSLSAKVVDDEIYYFRKPIVPQKEPSPLLEKKIQLLEAKFAELEGGDDDIEEMGEEDSE
VIEPPSLPQLQTPLASELDLMPYTPPQSTPKSAKGSAKKEGSKRKINMSGYILFSSEMRAVIKAQHPDYSFGELSRLVGTEWRNLETAKK
AEYEERAAKVAEQQERERAAQQQQPSASPRAGTPVGALMGVVPPPTPMGMLNQQLTPVAAFETELAYLSGNRLTVDEQEKSIICSVSPKQ
ELCAWDVQEVGDAAGDIYTFTLPGLRDVSKVTAFQYGIVLLHCSPDKKWVFACGTYSRTLPQVFLTESLLRPSEGSVPLSTFLPHKLCAS
ACWTPKVKNRITLMSQSSTGKKTEFITFDLTTKKTGGQTVIQAYEIASFQVAAHLKCPIWMGASDGYMIVFTSGPYLLLFSITGFLLQRF

--------------------------------------------------------------

>63000_63000_6_PBRM1-FBXW12_PBRM1_chr3_52592265_ENST00000409114_FBXW12_chr3_48416844_ENST00000445170_length(amino acids)=1868AA_BP=1499
MGSKRRRATSPSSSVSGDFDDGHHSVSTPGPSRKRRRLSNLPTVDPIAVCHELYNTIRDYKDEQGRLLCELFIRAPKRRNQPDYYEVVSQ
PIDLMKIQQKLKMEEYDDVNLLTADFQLLFNNAKSYYKPDSPEYKAACKLWDLYLRTRNEFVQKGEADDEDDDEDGQDNQGTVTEGSSPA
YLKEILEQLLEAIVVATNPSGRLISELFQKLPSKVQYPDYYAIIKEPIDLKTIAQRIQNGSYKSIHAMAKDIDLLAKNAKTYNEPGSQVF
KDANSIKKIFYMKKAEIEHHEMAKSSLRMRTPSNLAAARLTGPSHSKGSLGEERNPTSKYYRNKRAVQGGRLSAITMALQYGSESEEDAA
LAAARYEEGESEAESITSFMDVSNPFYQLYDTVRSCRNNQGQLIAEPFYHLPSKKKYPDYYQQIKMPISLQQIRTKLKNQEYETLDHLEC
DLNLMFENAKRYNVPNSAIYKRVLKLQQVMQAKKKELARRDDIEDGDSMISSATSDTGSAKRKRNTHDSEMLGLRRLSSKKNIRKQRMKI
LFNVVLEAREPGSGRRLCDLFMVKPSKKDYPDYYKIILEPMDLKIIEHNIRNDKYAGEEGMIEDMKLMFRNARHYNEEGSQVYNDAHILE
KLLKEKRKELGPLPDDDDMASPKLKLSRKSGISPKKSKYMTPMQQKLNEVYEAVKNYTDKRGRRLSAIFLRLPSRSELPDYYLTIKKPMD
MEKIRSHMMANKYQDIDSMVEDFVMMFNNACTYNEPESLIYKDALVLHKVLLETRRDLEGDEDSHVPNVTLLIQELIHNLFVSVMSHQDD
EGRCYSDSLAEIPAVDPNFPNKPPLTFDIIRKNVENNRYRRLDLFQEHMFEVLERARRMNRTDSEIYEDAVELQQFFIKIRDELCKNGEI
LLSPALSYTTKHLHNDVEKERKEKLPKEIEEDKLKREEEKREAEKSEDSSGAAGLSGLHRTYSQDCSFKNSMYHVGDYVYVEPAEANLQP
HIVCIERLWEDSAGEKWLYGCWFYRPNETFHLATRKFLEKEVFKSDYYNKVPVSKILGKCVVMFVKEYFKLCPENFRDEDVFVCESRYSA
KTKSFKKIKLWTMPISSVRFVPRDVPLPVVRVASVFANADKGDDEKNTDNSEDSRAEDNFNLEKEKEDVPVEMSNGEPGCHYFEQLHYND
MWLKVGDCVFIKSHGLVRPRVGRIEKVWVRDGAAYFYGPIFIHPEETEHEPTKMFYKKEVFLSNLEETCPMTCILGKCAVLSFKDFLSCR
PTEIPENDILLCESRYNESDKQMKKFKGLKRFSLSAKVVDDEIYYFRKPIVPQKEPSPLLEKKIQLLEAKFAELEGGDDDIEEMGEEDSE
VIEPPSLPQLQTPLASELDLMPYTPPQSTPKSAKGSAKKEGSKRKINMSGYILFSSEMRAVIKAQHPDYSFGELSRLVGTEWRNLETAKK
AEYEERAAKVAEQQERERAAQQQQPSASPRAGTPVGALMGVVPPPTPMGMLNQQLTPVAAFETELAYLSGNRLTVDEQEKSIICSVSPKQ
ELCAWDVQEGTMIWSSPVQEFHFSNLVTLPQMHLAITMDRKKTIKVWNCQDRDALAVLPMPQPCYCMEAYLTKDGPFLMVGDAAGDIYTF
TLPGLRDVSKVTAFQYGIVLLHCSPDKKWVFACGTYSRTLPQVFLTESLLRPSEGSVPLSTFLPHKLCASACWTPKVKNRITLMSQSSTG
KKTEFITFDLTTKKTGGQTVIQAYEIASFQVAAHLKCPIWMGASDGYMIVFTSGPYLLLFSITGFLLQRFEDHQAAINNFWVDPCYVLTT

--------------------------------------------------------------

>63000_63000_7_PBRM1-FBXW12_PBRM1_chr3_52595783_ENST00000296302_FBXW12_chr3_48416844_ENST00000296438_length(amino acids)=1798AA_BP=1429
MGSKRRRATSPSSSVSGDFDDGHHSVSTPGPSRKRRRLSNLPTVDPIAVCHELYNTIRDYKDEQGRLLCELFIRAPKRRNQPDYYEVVSQ
PIDLMKIQQKLKMEEYDDVNLLTADFQLLFNNAKSYYKPDSPEYKAACKLWDLYLRTRNEFVQKGEADDEDDDEDGQDNQGTVTEGSSPA
YLKEILEQLLEAIVVATNPSGRLISELFQKLPSKVQYPDYYAIIKEPIDLKTIAQRIQNGSYKSIHAMAKDIDLLAKNAKTYNEPGSQVF
KDANSIKKIFYMKKAEIEHHEMAKSSLRMRTPSNLAAARLTGPSHSKGSLGEERNPTSKYYRNKRAVQGGRLSAITMALQYGSESEEDAA
LAAARYEEGESEAESITSFMDVSNPFYQLYDTVRSCRNNQGQLIAEPFYHLPSKKKYPDYYQQIKMPISLQQIRTKLKNQEYETLDHLEC
DLNLMFENAKRYNVPNSAIYKRVLKLQQVMQAKKKELARRDDIEDGDSMISSATSDTGSAKRKSKKNIRKQRMKILFNVVLEAREPGSGR
RLCDLFMVKPSKKDYPDYYKIILEPMDLKIIEHNIRNDKYAGEEGMIEDMKLMFRNARHYNEEGSQVYNDAHILEKLLKEKRKELGPLPD
DDDMASPKLKLSRKSGISPKKSKYMTPMQQKLNEVYEAVKNYTDKRGRRLSAIFLRLPSRSELPDYYLTIKKPMDMEKIRSHMMANKYQD
IDSMVEDFVMMFNNACTYNEPESLIYKDALVLHKVLLETRRDLEGDEDSHVPNVTLLIQELIHNLFVSVMSHQDDEGRCYSDSLAEIPAV
DPNFPNKPPLTFDIIRKNVENNRYRRLDLFQEHMFEVLERARRMNRTDSEIYEDAVELQQFFIKIRDELCKNGEILLSPALSYTTKHLHN
DVEKERKEKLPKEIEEDKLKREEEKREAEKSEDSSGAAGLSGLHRTYSQDCSFKNSMYHVGDYVYVEPAEANLQPHIVCIERLWEDSAGE
KWLYGCWFYRPNETFHLATRKFLEKEVFKSDYYNKVPVSKILGKCVVMFVKEYFKLCPENFRDEDVFVCESRYSAKTKSFKKIKLWTMPI
SSVRFVPRDVPLPVVRVASVFANADKGDDEKNTDNSEDSRAEDNFNLEKEKEDVPVEMSNGEPGCHYFEQLHYNDMWLKVGDCVFIKSHG
LVRPRVGRIEKVWVRDGAAYFYGPIFIHPEETEHEPTKMFYKKEVFLSNLEETCPMTCILGKCAVLSFKDFLSCRPTEIPENDILLCESR
YNESDKQMKKFKGLKRFSLSAKVVDDEIYYFRKPIVPQKEPSPLLEKKIQLLEAKFAELEGGDDDIEEMGEEDSEVIEPPSLPQLQTPLA
SELDLMPYTPPQSTPKSAKGSAKKEGSKRKINMSGYILFSSEMRAVIKAQHPDYSFGELSRLVGTEWRNLETAKKAEYEAFETELAYLSG
NRLTVDEQEKSIICSVSPKQELCAWDVQEGTMIWSSPVQEFHFSNLVTLPQMHLAITMDRKKTIKVWNCQDRDALAVLPMPQPCYCMEAY
LTKDGPFLMVGDAAGDIYTFTLPGLRDVSKVTAFQYGIVLLHCSPDKKWVFACGTYSRTLPQVFLTESLLRPSEGSVPLSTFLPHKLCAS
ACWTPKVKNRITLMSQSSTGKKTEFITFDLTTKKTGGQTVIQAYEIASFQVAAHLKCPIWMGASDGYMIVFTSGPYLLLFSITGFLLQRF

--------------------------------------------------------------

>63000_63000_8_PBRM1-FBXW12_PBRM1_chr3_52595783_ENST00000296302_FBXW12_chr3_48416844_ENST00000415155_length(amino acids)=1728AA_BP=1429
MGSKRRRATSPSSSVSGDFDDGHHSVSTPGPSRKRRRLSNLPTVDPIAVCHELYNTIRDYKDEQGRLLCELFIRAPKRRNQPDYYEVVSQ
PIDLMKIQQKLKMEEYDDVNLLTADFQLLFNNAKSYYKPDSPEYKAACKLWDLYLRTRNEFVQKGEADDEDDDEDGQDNQGTVTEGSSPA
YLKEILEQLLEAIVVATNPSGRLISELFQKLPSKVQYPDYYAIIKEPIDLKTIAQRIQNGSYKSIHAMAKDIDLLAKNAKTYNEPGSQVF
KDANSIKKIFYMKKAEIEHHEMAKSSLRMRTPSNLAAARLTGPSHSKGSLGEERNPTSKYYRNKRAVQGGRLSAITMALQYGSESEEDAA
LAAARYEEGESEAESITSFMDVSNPFYQLYDTVRSCRNNQGQLIAEPFYHLPSKKKYPDYYQQIKMPISLQQIRTKLKNQEYETLDHLEC
DLNLMFENAKRYNVPNSAIYKRVLKLQQVMQAKKKELARRDDIEDGDSMISSATSDTGSAKRKSKKNIRKQRMKILFNVVLEAREPGSGR
RLCDLFMVKPSKKDYPDYYKIILEPMDLKIIEHNIRNDKYAGEEGMIEDMKLMFRNARHYNEEGSQVYNDAHILEKLLKEKRKELGPLPD
DDDMASPKLKLSRKSGISPKKSKYMTPMQQKLNEVYEAVKNYTDKRGRRLSAIFLRLPSRSELPDYYLTIKKPMDMEKIRSHMMANKYQD
IDSMVEDFVMMFNNACTYNEPESLIYKDALVLHKVLLETRRDLEGDEDSHVPNVTLLIQELIHNLFVSVMSHQDDEGRCYSDSLAEIPAV
DPNFPNKPPLTFDIIRKNVENNRYRRLDLFQEHMFEVLERARRMNRTDSEIYEDAVELQQFFIKIRDELCKNGEILLSPALSYTTKHLHN
DVEKERKEKLPKEIEEDKLKREEEKREAEKSEDSSGAAGLSGLHRTYSQDCSFKNSMYHVGDYVYVEPAEANLQPHIVCIERLWEDSAGE
KWLYGCWFYRPNETFHLATRKFLEKEVFKSDYYNKVPVSKILGKCVVMFVKEYFKLCPENFRDEDVFVCESRYSAKTKSFKKIKLWTMPI
SSVRFVPRDVPLPVVRVASVFANADKGDDEKNTDNSEDSRAEDNFNLEKEKEDVPVEMSNGEPGCHYFEQLHYNDMWLKVGDCVFIKSHG
LVRPRVGRIEKVWVRDGAAYFYGPIFIHPEETEHEPTKMFYKKEVFLSNLEETCPMTCILGKCAVLSFKDFLSCRPTEIPENDILLCESR
YNESDKQMKKFKGLKRFSLSAKVVDDEIYYFRKPIVPQKEPSPLLEKKIQLLEAKFAELEGGDDDIEEMGEEDSEVIEPPSLPQLQTPLA
SELDLMPYTPPQSTPKSAKGSAKKEGSKRKINMSGYILFSSEMRAVIKAQHPDYSFGELSRLVGTEWRNLETAKKAEYEAFETELAYLSG
NRLTVDEQEKSIICSVSPKQELCAWDVQEVGDAAGDIYTFTLPGLRDVSKVTAFQYGIVLLHCSPDKKWVFACGTYSRTLPQVFLTESLL
RPSEGSVPLSTFLPHKLCASACWTPKVKNRITLMSQSSTGKKTEFITFDLTTKKTGGQTVIQAYEIASFQVAAHLKCPIWMGASDGYMIV
FTSGPYLLLFSITGFLLQRFEDHQAAINNFWVDPCYVLTTSENSVHVYMWEEGGRHPYLRSCCHLENTWHDHTTDSCISSVMCDNASIVL

--------------------------------------------------------------

>63000_63000_9_PBRM1-FBXW12_PBRM1_chr3_52595783_ENST00000296302_FBXW12_chr3_48416844_ENST00000445170_length(amino acids)=1798AA_BP=1429
MGSKRRRATSPSSSVSGDFDDGHHSVSTPGPSRKRRRLSNLPTVDPIAVCHELYNTIRDYKDEQGRLLCELFIRAPKRRNQPDYYEVVSQ
PIDLMKIQQKLKMEEYDDVNLLTADFQLLFNNAKSYYKPDSPEYKAACKLWDLYLRTRNEFVQKGEADDEDDDEDGQDNQGTVTEGSSPA
YLKEILEQLLEAIVVATNPSGRLISELFQKLPSKVQYPDYYAIIKEPIDLKTIAQRIQNGSYKSIHAMAKDIDLLAKNAKTYNEPGSQVF
KDANSIKKIFYMKKAEIEHHEMAKSSLRMRTPSNLAAARLTGPSHSKGSLGEERNPTSKYYRNKRAVQGGRLSAITMALQYGSESEEDAA
LAAARYEEGESEAESITSFMDVSNPFYQLYDTVRSCRNNQGQLIAEPFYHLPSKKKYPDYYQQIKMPISLQQIRTKLKNQEYETLDHLEC
DLNLMFENAKRYNVPNSAIYKRVLKLQQVMQAKKKELARRDDIEDGDSMISSATSDTGSAKRKSKKNIRKQRMKILFNVVLEAREPGSGR
RLCDLFMVKPSKKDYPDYYKIILEPMDLKIIEHNIRNDKYAGEEGMIEDMKLMFRNARHYNEEGSQVYNDAHILEKLLKEKRKELGPLPD
DDDMASPKLKLSRKSGISPKKSKYMTPMQQKLNEVYEAVKNYTDKRGRRLSAIFLRLPSRSELPDYYLTIKKPMDMEKIRSHMMANKYQD
IDSMVEDFVMMFNNACTYNEPESLIYKDALVLHKVLLETRRDLEGDEDSHVPNVTLLIQELIHNLFVSVMSHQDDEGRCYSDSLAEIPAV
DPNFPNKPPLTFDIIRKNVENNRYRRLDLFQEHMFEVLERARRMNRTDSEIYEDAVELQQFFIKIRDELCKNGEILLSPALSYTTKHLHN
DVEKERKEKLPKEIEEDKLKREEEKREAEKSEDSSGAAGLSGLHRTYSQDCSFKNSMYHVGDYVYVEPAEANLQPHIVCIERLWEDSAGE
KWLYGCWFYRPNETFHLATRKFLEKEVFKSDYYNKVPVSKILGKCVVMFVKEYFKLCPENFRDEDVFVCESRYSAKTKSFKKIKLWTMPI
SSVRFVPRDVPLPVVRVASVFANADKGDDEKNTDNSEDSRAEDNFNLEKEKEDVPVEMSNGEPGCHYFEQLHYNDMWLKVGDCVFIKSHG
LVRPRVGRIEKVWVRDGAAYFYGPIFIHPEETEHEPTKMFYKKEVFLSNLEETCPMTCILGKCAVLSFKDFLSCRPTEIPENDILLCESR
YNESDKQMKKFKGLKRFSLSAKVVDDEIYYFRKPIVPQKEPSPLLEKKIQLLEAKFAELEGGDDDIEEMGEEDSEVIEPPSLPQLQTPLA
SELDLMPYTPPQSTPKSAKGSAKKEGSKRKINMSGYILFSSEMRAVIKAQHPDYSFGELSRLVGTEWRNLETAKKAEYEAFETELAYLSG
NRLTVDEQEKSIICSVSPKQELCAWDVQEGTMIWSSPVQEFHFSNLVTLPQMHLAITMDRKKTIKVWNCQDRDALAVLPMPQPCYCMEAY
LTKDGPFLMVGDAAGDIYTFTLPGLRDVSKVTAFQYGIVLLHCSPDKKWVFACGTYSRTLPQVFLTESLLRPSEGSVPLSTFLPHKLCAS
ACWTPKVKNRITLMSQSSTGKKTEFITFDLTTKKTGGQTVIQAYEIASFQVAAHLKCPIWMGASDGYMIVFTSGPYLLLFSITGFLLQRF

--------------------------------------------------------------

>63000_63000_10_PBRM1-FBXW12_PBRM1_chr3_52595783_ENST00000337303_FBXW12_chr3_48416844_ENST00000296438_length(amino acids)=1798AA_BP=1429
MGSKRRRATSPSSSVSGDFDDGHHSVSTPGPSRKRRRLSNLPTVDPIAVCHELYNTIRDYKDEQGRLLCELFIRAPKRRNQPDYYEVVSQ
PIDLMKIQQKLKMEEYDDVNLLTADFQLLFNNAKSYYKPDSPEYKAACKLWDLYLRTRNEFVQKGEADDEDDDEDGQDNQGTVTEGSSPA
YLKEILEQLLEAIVVATNPSGRLISELFQKLPSKVQYPDYYAIIKEPIDLKTIAQRIQNGSYKSIHAMAKDIDLLAKNAKTYNEPGSQVF
KDANSIKKIFYMKKAEIEHHEMAKSSLRMRTPSNLAAARLTGPSHSKGSLGEERNPTSKYYRNKRAVQGGRLSAITMALQYGSESEEDAA
LAAARYEEGESEAESITSFMDVSNPFYQLYDTVRSCRNNQGQLIAEPFYHLPSKKKYPDYYQQIKMPISLQQIRTKLKNQEYETLDHLEC
DLNLMFENAKRYNVPNSAIYKRVLKLQQVMQAKKKELARRDDIEDGDSMISSATSDTGSAKRKSKKNIRKQRMKILFNVVLEAREPGSGR
RLCDLFMVKPSKKDYPDYYKIILEPMDLKIIEHNIRNDKYAGEEGMIEDMKLMFRNARHYNEEGSQVYNDAHILEKLLKEKRKELGPLPD
DDDMASPKLKLSRKSGISPKKSKYMTPMQQKLNEVYEAVKNYTDKRGRRLSAIFLRLPSRSELPDYYLTIKKPMDMEKIRSHMMANKYQD
IDSMVEDFVMMFNNACTYNEPESLIYKDALVLHKVLLETRRDLEGDEDSHVPNVTLLIQELIHNLFVSVMSHQDDEGRCYSDSLAEIPAV
DPNFPNKPPLTFDIIRKNVENNRYRRLDLFQEHMFEVLERARRMNRTDSEIYEDAVELQQFFIKIRDELCKNGEILLSPALSYTTKHLHN
DVEKERKEKLPKEIEEDKLKREEEKREAEKSEDSSGAAGLSGLHRTYSQDCSFKNSMYHVGDYVYVEPAEANLQPHIVCIERLWEDSAGE
KWLYGCWFYRPNETFHLATRKFLEKEVFKSDYYNKVPVSKILGKCVVMFVKEYFKLCPENFRDEDVFVCESRYSAKTKSFKKIKLWTMPI
SSVRFVPRDVPLPVVRVASVFANADKGDDEKNTDNSEDSRAEDNFNLEKEKEDVPVEMSNGEPGCHYFEQLHYNDMWLKVGDCVFIKSHG
LVRPRVGRIEKVWVRDGAAYFYGPIFIHPEETEHEPTKMFYKKEVFLSNLEETCPMTCILGKCAVLSFKDFLSCRPTEIPENDILLCESR
YNESDKQMKKFKGLKRFSLSAKVVDDEIYYFRKPIVPQKEPSPLLEKKIQLLEAKFAELEGGDDDIEEMGEEDSEVIEPPSLPQLQTPLA
SELDLMPYTPPQSTPKSAKGSAKKEGSKRKINMSGYILFSSEMRAVIKAQHPDYSFGELSRLVGTEWRNLETAKKAEYEAFETELAYLSG
NRLTVDEQEKSIICSVSPKQELCAWDVQEGTMIWSSPVQEFHFSNLVTLPQMHLAITMDRKKTIKVWNCQDRDALAVLPMPQPCYCMEAY
LTKDGPFLMVGDAAGDIYTFTLPGLRDVSKVTAFQYGIVLLHCSPDKKWVFACGTYSRTLPQVFLTESLLRPSEGSVPLSTFLPHKLCAS
ACWTPKVKNRITLMSQSSTGKKTEFITFDLTTKKTGGQTVIQAYEIASFQVAAHLKCPIWMGASDGYMIVFTSGPYLLLFSITGFLLQRF

--------------------------------------------------------------

>63000_63000_11_PBRM1-FBXW12_PBRM1_chr3_52595783_ENST00000337303_FBXW12_chr3_48416844_ENST00000415155_length(amino acids)=1728AA_BP=1429
MGSKRRRATSPSSSVSGDFDDGHHSVSTPGPSRKRRRLSNLPTVDPIAVCHELYNTIRDYKDEQGRLLCELFIRAPKRRNQPDYYEVVSQ
PIDLMKIQQKLKMEEYDDVNLLTADFQLLFNNAKSYYKPDSPEYKAACKLWDLYLRTRNEFVQKGEADDEDDDEDGQDNQGTVTEGSSPA
YLKEILEQLLEAIVVATNPSGRLISELFQKLPSKVQYPDYYAIIKEPIDLKTIAQRIQNGSYKSIHAMAKDIDLLAKNAKTYNEPGSQVF
KDANSIKKIFYMKKAEIEHHEMAKSSLRMRTPSNLAAARLTGPSHSKGSLGEERNPTSKYYRNKRAVQGGRLSAITMALQYGSESEEDAA
LAAARYEEGESEAESITSFMDVSNPFYQLYDTVRSCRNNQGQLIAEPFYHLPSKKKYPDYYQQIKMPISLQQIRTKLKNQEYETLDHLEC
DLNLMFENAKRYNVPNSAIYKRVLKLQQVMQAKKKELARRDDIEDGDSMISSATSDTGSAKRKSKKNIRKQRMKILFNVVLEAREPGSGR
RLCDLFMVKPSKKDYPDYYKIILEPMDLKIIEHNIRNDKYAGEEGMIEDMKLMFRNARHYNEEGSQVYNDAHILEKLLKEKRKELGPLPD
DDDMASPKLKLSRKSGISPKKSKYMTPMQQKLNEVYEAVKNYTDKRGRRLSAIFLRLPSRSELPDYYLTIKKPMDMEKIRSHMMANKYQD
IDSMVEDFVMMFNNACTYNEPESLIYKDALVLHKVLLETRRDLEGDEDSHVPNVTLLIQELIHNLFVSVMSHQDDEGRCYSDSLAEIPAV
DPNFPNKPPLTFDIIRKNVENNRYRRLDLFQEHMFEVLERARRMNRTDSEIYEDAVELQQFFIKIRDELCKNGEILLSPALSYTTKHLHN
DVEKERKEKLPKEIEEDKLKREEEKREAEKSEDSSGAAGLSGLHRTYSQDCSFKNSMYHVGDYVYVEPAEANLQPHIVCIERLWEDSAGE
KWLYGCWFYRPNETFHLATRKFLEKEVFKSDYYNKVPVSKILGKCVVMFVKEYFKLCPENFRDEDVFVCESRYSAKTKSFKKIKLWTMPI
SSVRFVPRDVPLPVVRVASVFANADKGDDEKNTDNSEDSRAEDNFNLEKEKEDVPVEMSNGEPGCHYFEQLHYNDMWLKVGDCVFIKSHG
LVRPRVGRIEKVWVRDGAAYFYGPIFIHPEETEHEPTKMFYKKEVFLSNLEETCPMTCILGKCAVLSFKDFLSCRPTEIPENDILLCESR
YNESDKQMKKFKGLKRFSLSAKVVDDEIYYFRKPIVPQKEPSPLLEKKIQLLEAKFAELEGGDDDIEEMGEEDSEVIEPPSLPQLQTPLA
SELDLMPYTPPQSTPKSAKGSAKKEGSKRKINMSGYILFSSEMRAVIKAQHPDYSFGELSRLVGTEWRNLETAKKAEYEAFETELAYLSG
NRLTVDEQEKSIICSVSPKQELCAWDVQEVGDAAGDIYTFTLPGLRDVSKVTAFQYGIVLLHCSPDKKWVFACGTYSRTLPQVFLTESLL
RPSEGSVPLSTFLPHKLCASACWTPKVKNRITLMSQSSTGKKTEFITFDLTTKKTGGQTVIQAYEIASFQVAAHLKCPIWMGASDGYMIV
FTSGPYLLLFSITGFLLQRFEDHQAAINNFWVDPCYVLTTSENSVHVYMWEEGGRHPYLRSCCHLENTWHDHTTDSCISSVMCDNASIVL

--------------------------------------------------------------

>63000_63000_12_PBRM1-FBXW12_PBRM1_chr3_52595783_ENST00000337303_FBXW12_chr3_48416844_ENST00000445170_length(amino acids)=1798AA_BP=1429
MGSKRRRATSPSSSVSGDFDDGHHSVSTPGPSRKRRRLSNLPTVDPIAVCHELYNTIRDYKDEQGRLLCELFIRAPKRRNQPDYYEVVSQ
PIDLMKIQQKLKMEEYDDVNLLTADFQLLFNNAKSYYKPDSPEYKAACKLWDLYLRTRNEFVQKGEADDEDDDEDGQDNQGTVTEGSSPA
YLKEILEQLLEAIVVATNPSGRLISELFQKLPSKVQYPDYYAIIKEPIDLKTIAQRIQNGSYKSIHAMAKDIDLLAKNAKTYNEPGSQVF
KDANSIKKIFYMKKAEIEHHEMAKSSLRMRTPSNLAAARLTGPSHSKGSLGEERNPTSKYYRNKRAVQGGRLSAITMALQYGSESEEDAA
LAAARYEEGESEAESITSFMDVSNPFYQLYDTVRSCRNNQGQLIAEPFYHLPSKKKYPDYYQQIKMPISLQQIRTKLKNQEYETLDHLEC
DLNLMFENAKRYNVPNSAIYKRVLKLQQVMQAKKKELARRDDIEDGDSMISSATSDTGSAKRKSKKNIRKQRMKILFNVVLEAREPGSGR
RLCDLFMVKPSKKDYPDYYKIILEPMDLKIIEHNIRNDKYAGEEGMIEDMKLMFRNARHYNEEGSQVYNDAHILEKLLKEKRKELGPLPD
DDDMASPKLKLSRKSGISPKKSKYMTPMQQKLNEVYEAVKNYTDKRGRRLSAIFLRLPSRSELPDYYLTIKKPMDMEKIRSHMMANKYQD
IDSMVEDFVMMFNNACTYNEPESLIYKDALVLHKVLLETRRDLEGDEDSHVPNVTLLIQELIHNLFVSVMSHQDDEGRCYSDSLAEIPAV
DPNFPNKPPLTFDIIRKNVENNRYRRLDLFQEHMFEVLERARRMNRTDSEIYEDAVELQQFFIKIRDELCKNGEILLSPALSYTTKHLHN
DVEKERKEKLPKEIEEDKLKREEEKREAEKSEDSSGAAGLSGLHRTYSQDCSFKNSMYHVGDYVYVEPAEANLQPHIVCIERLWEDSAGE
KWLYGCWFYRPNETFHLATRKFLEKEVFKSDYYNKVPVSKILGKCVVMFVKEYFKLCPENFRDEDVFVCESRYSAKTKSFKKIKLWTMPI
SSVRFVPRDVPLPVVRVASVFANADKGDDEKNTDNSEDSRAEDNFNLEKEKEDVPVEMSNGEPGCHYFEQLHYNDMWLKVGDCVFIKSHG
LVRPRVGRIEKVWVRDGAAYFYGPIFIHPEETEHEPTKMFYKKEVFLSNLEETCPMTCILGKCAVLSFKDFLSCRPTEIPENDILLCESR
YNESDKQMKKFKGLKRFSLSAKVVDDEIYYFRKPIVPQKEPSPLLEKKIQLLEAKFAELEGGDDDIEEMGEEDSEVIEPPSLPQLQTPLA
SELDLMPYTPPQSTPKSAKGSAKKEGSKRKINMSGYILFSSEMRAVIKAQHPDYSFGELSRLVGTEWRNLETAKKAEYEAFETELAYLSG
NRLTVDEQEKSIICSVSPKQELCAWDVQEGTMIWSSPVQEFHFSNLVTLPQMHLAITMDRKKTIKVWNCQDRDALAVLPMPQPCYCMEAY
LTKDGPFLMVGDAAGDIYTFTLPGLRDVSKVTAFQYGIVLLHCSPDKKWVFACGTYSRTLPQVFLTESLLRPSEGSVPLSTFLPHKLCAS
ACWTPKVKNRITLMSQSSTGKKTEFITFDLTTKKTGGQTVIQAYEIASFQVAAHLKCPIWMGASDGYMIVFTSGPYLLLFSITGFLLQRF

--------------------------------------------------------------

>63000_63000_13_PBRM1-FBXW12_PBRM1_chr3_52595783_ENST00000356770_FBXW12_chr3_48416844_ENST00000296438_length(amino acids)=1766AA_BP=1397
MGSKRRRATSPSSSVSGDFDDGHHSVSTPGPSRKRRRLSNLPTVDPIAVCHELYNTIRDYKDEQGRLLCELFIRAPKRRNQPDYYEVVSQ
PIDLMKIQQKLKMEEYDDVNLLTADFQLLFNNAKSYYKPDSPEYKAACKLWDLYLRTRNEFVQKGEADDEDDDEDGQDNQGTVTEGSSPA
YLKEILEQLLEAIVVATNPSGRLISELFQKLPSKVQYPDYYAIIKEPIDLKTIAQRIQNGSYKSIHAMAKDIDLLAKNAKTYNEPGSQVF
KDANSIKKIFYMKKAEIEHHEMAKSSLRMSNKRAVQGGRLSAITMALQYGSESEEDAALAAARYEEGESEAESITSFMDVSNPFYQLYDT
VRSCRNNQGQLIAEPFYHLPSKKKYPDYYQQIKMPISLQQIRTKLKNQEYETLDHLECDLNLMFENAKRYNVPNSAIYKRVLKLQQVMQA
KKKELARRDDIEDGDSMISSATSDTGSAKRKSKKNIRKQRMKILFNVVLEAREPGSGRRLCDLFMVKPSKKDYPDYYKIILEPMDLKIIE
HNIRNDKYAGEEGMIEDMKLMFRNARHYNEEGSQVYNDAHILEKLLKEKRKELGPLPDDDDMASPKLKLSRKSGISPKKSKYMTPMQQKL
NEVYEAVKNYTDKRGRRLSAIFLRLPSRSELPDYYLTIKKPMDMEKIRSHMMANKYQDIDSMVEDFVMMFNNACTYNEPESLIYKDALVL
HKVLLETRRDLEGDEDSHVPNVTLLIQELIHNLFVSVMSHQDDEGRCYSDSLAEIPAVDPNFPNKPPLTFDIIRKNVENNRYRRLDLFQE
HMFEVLERARRMNRTDSEIYEDAVELQQFFIKIRDELCKNGEILLSPALSYTTKHLHNDVEKERKEKLPKEIEEDKLKREEEKREAEKSE
DSSGAAGLSGLHRTYSQDCSFKNSMYHVGDYVYVEPAEANLQPHIVCIERLWEDSAGEKWLYGCWFYRPNETFHLATRKFLEKEVFKSDY
YNKVPVSKILGKCVVMFVKEYFKLCPENFRDEDVFVCESRYSAKTKSFKKIKLWTMPISSVRFVPRDVPLPVVRVASVFANADKGDDEKN
TDNSEDSRAEDNFNLEKEKEDVPVEMSNGEPGCHYFEQLHYNDMWLKVGDCVFIKSHGLVRPRVGRIEKVWVRDGAAYFYGPIFIHPEET
EHEPTKMFYKKEVFLSNLEETCPMTCILGKCAVLSFKDFLSCRPTEIPENDILLCESRYNESDKQMKKFKGLKRFSLSAKVVDDEIYYFR
KPIVPQKEPSPLLEKKIQLLEAKFAELEGGDDDIEEMGEEDSEVIEPPSLPQLQTPLASELDLMPYTPPQSTPKSAKGSAKKEGSKRKIN
MSGYILFSSEMRAVIKAQHPDYSFGELSRLVGTEWRNLETAKKAEYEAFETELAYLSGNRLTVDEQEKSIICSVSPKQELCAWDVQEGTM
IWSSPVQEFHFSNLVTLPQMHLAITMDRKKTIKVWNCQDRDALAVLPMPQPCYCMEAYLTKDGPFLMVGDAAGDIYTFTLPGLRDVSKVT
AFQYGIVLLHCSPDKKWVFACGTYSRTLPQVFLTESLLRPSEGSVPLSTFLPHKLCASACWTPKVKNRITLMSQSSTGKKTEFITFDLTT
KKTGGQTVIQAYEIASFQVAAHLKCPIWMGASDGYMIVFTSGPYLLLFSITGFLLQRFEDHQAAINNFWVDPCYVLTTSENSVHVYMWEE

--------------------------------------------------------------

>63000_63000_14_PBRM1-FBXW12_PBRM1_chr3_52595783_ENST00000356770_FBXW12_chr3_48416844_ENST00000415155_length(amino acids)=1696AA_BP=1397
MGSKRRRATSPSSSVSGDFDDGHHSVSTPGPSRKRRRLSNLPTVDPIAVCHELYNTIRDYKDEQGRLLCELFIRAPKRRNQPDYYEVVSQ
PIDLMKIQQKLKMEEYDDVNLLTADFQLLFNNAKSYYKPDSPEYKAACKLWDLYLRTRNEFVQKGEADDEDDDEDGQDNQGTVTEGSSPA
YLKEILEQLLEAIVVATNPSGRLISELFQKLPSKVQYPDYYAIIKEPIDLKTIAQRIQNGSYKSIHAMAKDIDLLAKNAKTYNEPGSQVF
KDANSIKKIFYMKKAEIEHHEMAKSSLRMSNKRAVQGGRLSAITMALQYGSESEEDAALAAARYEEGESEAESITSFMDVSNPFYQLYDT
VRSCRNNQGQLIAEPFYHLPSKKKYPDYYQQIKMPISLQQIRTKLKNQEYETLDHLECDLNLMFENAKRYNVPNSAIYKRVLKLQQVMQA
KKKELARRDDIEDGDSMISSATSDTGSAKRKSKKNIRKQRMKILFNVVLEAREPGSGRRLCDLFMVKPSKKDYPDYYKIILEPMDLKIIE
HNIRNDKYAGEEGMIEDMKLMFRNARHYNEEGSQVYNDAHILEKLLKEKRKELGPLPDDDDMASPKLKLSRKSGISPKKSKYMTPMQQKL
NEVYEAVKNYTDKRGRRLSAIFLRLPSRSELPDYYLTIKKPMDMEKIRSHMMANKYQDIDSMVEDFVMMFNNACTYNEPESLIYKDALVL
HKVLLETRRDLEGDEDSHVPNVTLLIQELIHNLFVSVMSHQDDEGRCYSDSLAEIPAVDPNFPNKPPLTFDIIRKNVENNRYRRLDLFQE
HMFEVLERARRMNRTDSEIYEDAVELQQFFIKIRDELCKNGEILLSPALSYTTKHLHNDVEKERKEKLPKEIEEDKLKREEEKREAEKSE
DSSGAAGLSGLHRTYSQDCSFKNSMYHVGDYVYVEPAEANLQPHIVCIERLWEDSAGEKWLYGCWFYRPNETFHLATRKFLEKEVFKSDY
YNKVPVSKILGKCVVMFVKEYFKLCPENFRDEDVFVCESRYSAKTKSFKKIKLWTMPISSVRFVPRDVPLPVVRVASVFANADKGDDEKN
TDNSEDSRAEDNFNLEKEKEDVPVEMSNGEPGCHYFEQLHYNDMWLKVGDCVFIKSHGLVRPRVGRIEKVWVRDGAAYFYGPIFIHPEET
EHEPTKMFYKKEVFLSNLEETCPMTCILGKCAVLSFKDFLSCRPTEIPENDILLCESRYNESDKQMKKFKGLKRFSLSAKVVDDEIYYFR
KPIVPQKEPSPLLEKKIQLLEAKFAELEGGDDDIEEMGEEDSEVIEPPSLPQLQTPLASELDLMPYTPPQSTPKSAKGSAKKEGSKRKIN
MSGYILFSSEMRAVIKAQHPDYSFGELSRLVGTEWRNLETAKKAEYEAFETELAYLSGNRLTVDEQEKSIICSVSPKQELCAWDVQEVGD
AAGDIYTFTLPGLRDVSKVTAFQYGIVLLHCSPDKKWVFACGTYSRTLPQVFLTESLLRPSEGSVPLSTFLPHKLCASACWTPKVKNRIT
LMSQSSTGKKTEFITFDLTTKKTGGQTVIQAYEIASFQVAAHLKCPIWMGASDGYMIVFTSGPYLLLFSITGFLLQRFEDHQAAINNFWV

--------------------------------------------------------------

>63000_63000_15_PBRM1-FBXW12_PBRM1_chr3_52595783_ENST00000356770_FBXW12_chr3_48416844_ENST00000445170_length(amino acids)=1766AA_BP=1397
MGSKRRRATSPSSSVSGDFDDGHHSVSTPGPSRKRRRLSNLPTVDPIAVCHELYNTIRDYKDEQGRLLCELFIRAPKRRNQPDYYEVVSQ
PIDLMKIQQKLKMEEYDDVNLLTADFQLLFNNAKSYYKPDSPEYKAACKLWDLYLRTRNEFVQKGEADDEDDDEDGQDNQGTVTEGSSPA
YLKEILEQLLEAIVVATNPSGRLISELFQKLPSKVQYPDYYAIIKEPIDLKTIAQRIQNGSYKSIHAMAKDIDLLAKNAKTYNEPGSQVF
KDANSIKKIFYMKKAEIEHHEMAKSSLRMSNKRAVQGGRLSAITMALQYGSESEEDAALAAARYEEGESEAESITSFMDVSNPFYQLYDT
VRSCRNNQGQLIAEPFYHLPSKKKYPDYYQQIKMPISLQQIRTKLKNQEYETLDHLECDLNLMFENAKRYNVPNSAIYKRVLKLQQVMQA
KKKELARRDDIEDGDSMISSATSDTGSAKRKSKKNIRKQRMKILFNVVLEAREPGSGRRLCDLFMVKPSKKDYPDYYKIILEPMDLKIIE
HNIRNDKYAGEEGMIEDMKLMFRNARHYNEEGSQVYNDAHILEKLLKEKRKELGPLPDDDDMASPKLKLSRKSGISPKKSKYMTPMQQKL
NEVYEAVKNYTDKRGRRLSAIFLRLPSRSELPDYYLTIKKPMDMEKIRSHMMANKYQDIDSMVEDFVMMFNNACTYNEPESLIYKDALVL
HKVLLETRRDLEGDEDSHVPNVTLLIQELIHNLFVSVMSHQDDEGRCYSDSLAEIPAVDPNFPNKPPLTFDIIRKNVENNRYRRLDLFQE
HMFEVLERARRMNRTDSEIYEDAVELQQFFIKIRDELCKNGEILLSPALSYTTKHLHNDVEKERKEKLPKEIEEDKLKREEEKREAEKSE
DSSGAAGLSGLHRTYSQDCSFKNSMYHVGDYVYVEPAEANLQPHIVCIERLWEDSAGEKWLYGCWFYRPNETFHLATRKFLEKEVFKSDY
YNKVPVSKILGKCVVMFVKEYFKLCPENFRDEDVFVCESRYSAKTKSFKKIKLWTMPISSVRFVPRDVPLPVVRVASVFANADKGDDEKN
TDNSEDSRAEDNFNLEKEKEDVPVEMSNGEPGCHYFEQLHYNDMWLKVGDCVFIKSHGLVRPRVGRIEKVWVRDGAAYFYGPIFIHPEET
EHEPTKMFYKKEVFLSNLEETCPMTCILGKCAVLSFKDFLSCRPTEIPENDILLCESRYNESDKQMKKFKGLKRFSLSAKVVDDEIYYFR
KPIVPQKEPSPLLEKKIQLLEAKFAELEGGDDDIEEMGEEDSEVIEPPSLPQLQTPLASELDLMPYTPPQSTPKSAKGSAKKEGSKRKIN
MSGYILFSSEMRAVIKAQHPDYSFGELSRLVGTEWRNLETAKKAEYEAFETELAYLSGNRLTVDEQEKSIICSVSPKQELCAWDVQEGTM
IWSSPVQEFHFSNLVTLPQMHLAITMDRKKTIKVWNCQDRDALAVLPMPQPCYCMEAYLTKDGPFLMVGDAAGDIYTFTLPGLRDVSKVT
AFQYGIVLLHCSPDKKWVFACGTYSRTLPQVFLTESLLRPSEGSVPLSTFLPHKLCASACWTPKVKNRITLMSQSSTGKKTEFITFDLTT
KKTGGQTVIQAYEIASFQVAAHLKCPIWMGASDGYMIVFTSGPYLLLFSITGFLLQRFEDHQAAINNFWVDPCYVLTTSENSVHVYMWEE

--------------------------------------------------------------

>63000_63000_16_PBRM1-FBXW12_PBRM1_chr3_52595783_ENST00000409057_FBXW12_chr3_48416844_ENST00000296438_length(amino acids)=1798AA_BP=1429
MGSKRRRATSPSSSVSGDFDDGHHSVSTPGPSRKRRRLSNLPTVDPIAVCHELYNTIRDYKDEQGRLLCELFIRAPKRRNQPDYYEVVSQ
PIDLMKIQQKLKMEEYDDVNLLTADFQLLFNNAKSYYKPDSPEYKAACKLWDLYLRTRNEFVQKGEADDEDDDEDGQDNQGTVTEGSSPA
YLKEILEQLLEAIVVATNPSGRLISELFQKLPSKVQYPDYYAIIKEPIDLKTIAQRIQNGSYKSIHAMAKDIDLLAKNAKTYNEPGSQVF
KDANSIKKIFYMKKAEIEHHEMAKSSLRMRTPSNLAAARLTGPSHSKGSLGEERNPTSKYYRNKRAVQGGRLSAITMALQYGSESEEDAA
LAAARYEEGESEAESITSFMDVSNPFYQLYDTVRSCRNNQGQLIAEPFYHLPSKKKYPDYYQQIKMPISLQQIRTKLKNQEYETLDHLEC
DLNLMFENAKRYNVPNSAIYKRVLKLQQVMQAKKKELARRDDIEDGDSMISSATSDTGSAKRKSKKNIRKQRMKILFNVVLEAREPGSGR
RLCDLFMVKPSKKDYPDYYKIILEPMDLKIIEHNIRNDKYAGEEGMIEDMKLMFRNARHYNEEGSQVYNDAHILEKLLKEKRKELGPLPD
DDDMASPKLKLSRKSGISPKKSKYMTPMQQKLNEVYEAVKNYTDKRGRRLSAIFLRLPSRSELPDYYLTIKKPMDMEKIRSHMMANKYQD
IDSMVEDFVMMFNNACTYNEPESLIYKDALVLHKVLLETRRDLEGDEDSHVPNVTLLIQELIHNLFVSVMSHQDDEGRCYSDSLAEIPAV
DPNFPNKPPLTFDIIRKNVENNRYRRLDLFQEHMFEVLERARRMNRTDSEIYEDAVELQQFFIKIRDELCKNGEILLSPALSYTTKHLHN
DVEKERKEKLPKEIEEDKLKREEEKREAEKSEDSSGAAGLSGLHRTYSQDCSFKNSMYHVGDYVYVEPAEANLQPHIVCIERLWEDSAGE
KWLYGCWFYRPNETFHLATRKFLEKEVFKSDYYNKVPVSKILGKCVVMFVKEYFKLCPENFRDEDVFVCESRYSAKTKSFKKIKLWTMPI
SSVRFVPRDVPLPVVRVASVFANADKGDDEKNTDNSEDSRAEDNFNLEKEKEDVPVEMSNGEPGCHYFEQLHYNDMWLKVGDCVFIKSHG
LVRPRVGRIEKVWVRDGAAYFYGPIFIHPEETEHEPTKMFYKKEVFLSNLEETCPMTCILGKCAVLSFKDFLSCRPTEIPENDILLCESR
YNESDKQMKKFKGLKRFSLSAKVVDDEIYYFRKPIVPQKEPSPLLEKKIQLLEAKFAELEGGDDDIEEMGEEDSEVIEPPSLPQLQTPLA
SELDLMPYTPPQSTPKSAKGSAKKEGSKRKINMSGYILFSSEMRAVIKAQHPDYSFGELSRLVGTEWRNLETAKKAEYEAFETELAYLSG
NRLTVDEQEKSIICSVSPKQELCAWDVQEGTMIWSSPVQEFHFSNLVTLPQMHLAITMDRKKTIKVWNCQDRDALAVLPMPQPCYCMEAY
LTKDGPFLMVGDAAGDIYTFTLPGLRDVSKVTAFQYGIVLLHCSPDKKWVFACGTYSRTLPQVFLTESLLRPSEGSVPLSTFLPHKLCAS
ACWTPKVKNRITLMSQSSTGKKTEFITFDLTTKKTGGQTVIQAYEIASFQVAAHLKCPIWMGASDGYMIVFTSGPYLLLFSITGFLLQRF

--------------------------------------------------------------

>63000_63000_17_PBRM1-FBXW12_PBRM1_chr3_52595783_ENST00000409057_FBXW12_chr3_48416844_ENST00000415155_length(amino acids)=1728AA_BP=1429
MGSKRRRATSPSSSVSGDFDDGHHSVSTPGPSRKRRRLSNLPTVDPIAVCHELYNTIRDYKDEQGRLLCELFIRAPKRRNQPDYYEVVSQ
PIDLMKIQQKLKMEEYDDVNLLTADFQLLFNNAKSYYKPDSPEYKAACKLWDLYLRTRNEFVQKGEADDEDDDEDGQDNQGTVTEGSSPA
YLKEILEQLLEAIVVATNPSGRLISELFQKLPSKVQYPDYYAIIKEPIDLKTIAQRIQNGSYKSIHAMAKDIDLLAKNAKTYNEPGSQVF
KDANSIKKIFYMKKAEIEHHEMAKSSLRMRTPSNLAAARLTGPSHSKGSLGEERNPTSKYYRNKRAVQGGRLSAITMALQYGSESEEDAA
LAAARYEEGESEAESITSFMDVSNPFYQLYDTVRSCRNNQGQLIAEPFYHLPSKKKYPDYYQQIKMPISLQQIRTKLKNQEYETLDHLEC
DLNLMFENAKRYNVPNSAIYKRVLKLQQVMQAKKKELARRDDIEDGDSMISSATSDTGSAKRKSKKNIRKQRMKILFNVVLEAREPGSGR
RLCDLFMVKPSKKDYPDYYKIILEPMDLKIIEHNIRNDKYAGEEGMIEDMKLMFRNARHYNEEGSQVYNDAHILEKLLKEKRKELGPLPD
DDDMASPKLKLSRKSGISPKKSKYMTPMQQKLNEVYEAVKNYTDKRGRRLSAIFLRLPSRSELPDYYLTIKKPMDMEKIRSHMMANKYQD
IDSMVEDFVMMFNNACTYNEPESLIYKDALVLHKVLLETRRDLEGDEDSHVPNVTLLIQELIHNLFVSVMSHQDDEGRCYSDSLAEIPAV
DPNFPNKPPLTFDIIRKNVENNRYRRLDLFQEHMFEVLERARRMNRTDSEIYEDAVELQQFFIKIRDELCKNGEILLSPALSYTTKHLHN
DVEKERKEKLPKEIEEDKLKREEEKREAEKSEDSSGAAGLSGLHRTYSQDCSFKNSMYHVGDYVYVEPAEANLQPHIVCIERLWEDSAGE
KWLYGCWFYRPNETFHLATRKFLEKEVFKSDYYNKVPVSKILGKCVVMFVKEYFKLCPENFRDEDVFVCESRYSAKTKSFKKIKLWTMPI
SSVRFVPRDVPLPVVRVASVFANADKGDDEKNTDNSEDSRAEDNFNLEKEKEDVPVEMSNGEPGCHYFEQLHYNDMWLKVGDCVFIKSHG
LVRPRVGRIEKVWVRDGAAYFYGPIFIHPEETEHEPTKMFYKKEVFLSNLEETCPMTCILGKCAVLSFKDFLSCRPTEIPENDILLCESR
YNESDKQMKKFKGLKRFSLSAKVVDDEIYYFRKPIVPQKEPSPLLEKKIQLLEAKFAELEGGDDDIEEMGEEDSEVIEPPSLPQLQTPLA
SELDLMPYTPPQSTPKSAKGSAKKEGSKRKINMSGYILFSSEMRAVIKAQHPDYSFGELSRLVGTEWRNLETAKKAEYEAFETELAYLSG
NRLTVDEQEKSIICSVSPKQELCAWDVQEVGDAAGDIYTFTLPGLRDVSKVTAFQYGIVLLHCSPDKKWVFACGTYSRTLPQVFLTESLL
RPSEGSVPLSTFLPHKLCASACWTPKVKNRITLMSQSSTGKKTEFITFDLTTKKTGGQTVIQAYEIASFQVAAHLKCPIWMGASDGYMIV
FTSGPYLLLFSITGFLLQRFEDHQAAINNFWVDPCYVLTTSENSVHVYMWEEGGRHPYLRSCCHLENTWHDHTTDSCISSVMCDNASIVL

--------------------------------------------------------------

>63000_63000_18_PBRM1-FBXW12_PBRM1_chr3_52595783_ENST00000409057_FBXW12_chr3_48416844_ENST00000445170_length(amino acids)=1798AA_BP=1429
MGSKRRRATSPSSSVSGDFDDGHHSVSTPGPSRKRRRLSNLPTVDPIAVCHELYNTIRDYKDEQGRLLCELFIRAPKRRNQPDYYEVVSQ
PIDLMKIQQKLKMEEYDDVNLLTADFQLLFNNAKSYYKPDSPEYKAACKLWDLYLRTRNEFVQKGEADDEDDDEDGQDNQGTVTEGSSPA
YLKEILEQLLEAIVVATNPSGRLISELFQKLPSKVQYPDYYAIIKEPIDLKTIAQRIQNGSYKSIHAMAKDIDLLAKNAKTYNEPGSQVF
KDANSIKKIFYMKKAEIEHHEMAKSSLRMRTPSNLAAARLTGPSHSKGSLGEERNPTSKYYRNKRAVQGGRLSAITMALQYGSESEEDAA
LAAARYEEGESEAESITSFMDVSNPFYQLYDTVRSCRNNQGQLIAEPFYHLPSKKKYPDYYQQIKMPISLQQIRTKLKNQEYETLDHLEC
DLNLMFENAKRYNVPNSAIYKRVLKLQQVMQAKKKELARRDDIEDGDSMISSATSDTGSAKRKSKKNIRKQRMKILFNVVLEAREPGSGR
RLCDLFMVKPSKKDYPDYYKIILEPMDLKIIEHNIRNDKYAGEEGMIEDMKLMFRNARHYNEEGSQVYNDAHILEKLLKEKRKELGPLPD
DDDMASPKLKLSRKSGISPKKSKYMTPMQQKLNEVYEAVKNYTDKRGRRLSAIFLRLPSRSELPDYYLTIKKPMDMEKIRSHMMANKYQD
IDSMVEDFVMMFNNACTYNEPESLIYKDALVLHKVLLETRRDLEGDEDSHVPNVTLLIQELIHNLFVSVMSHQDDEGRCYSDSLAEIPAV
DPNFPNKPPLTFDIIRKNVENNRYRRLDLFQEHMFEVLERARRMNRTDSEIYEDAVELQQFFIKIRDELCKNGEILLSPALSYTTKHLHN
DVEKERKEKLPKEIEEDKLKREEEKREAEKSEDSSGAAGLSGLHRTYSQDCSFKNSMYHVGDYVYVEPAEANLQPHIVCIERLWEDSAGE
KWLYGCWFYRPNETFHLATRKFLEKEVFKSDYYNKVPVSKILGKCVVMFVKEYFKLCPENFRDEDVFVCESRYSAKTKSFKKIKLWTMPI
SSVRFVPRDVPLPVVRVASVFANADKGDDEKNTDNSEDSRAEDNFNLEKEKEDVPVEMSNGEPGCHYFEQLHYNDMWLKVGDCVFIKSHG
LVRPRVGRIEKVWVRDGAAYFYGPIFIHPEETEHEPTKMFYKKEVFLSNLEETCPMTCILGKCAVLSFKDFLSCRPTEIPENDILLCESR
YNESDKQMKKFKGLKRFSLSAKVVDDEIYYFRKPIVPQKEPSPLLEKKIQLLEAKFAELEGGDDDIEEMGEEDSEVIEPPSLPQLQTPLA
SELDLMPYTPPQSTPKSAKGSAKKEGSKRKINMSGYILFSSEMRAVIKAQHPDYSFGELSRLVGTEWRNLETAKKAEYEAFETELAYLSG
NRLTVDEQEKSIICSVSPKQELCAWDVQEGTMIWSSPVQEFHFSNLVTLPQMHLAITMDRKKTIKVWNCQDRDALAVLPMPQPCYCMEAY
LTKDGPFLMVGDAAGDIYTFTLPGLRDVSKVTAFQYGIVLLHCSPDKKWVFACGTYSRTLPQVFLTESLLRPSEGSVPLSTFLPHKLCAS
ACWTPKVKNRITLMSQSSTGKKTEFITFDLTTKKTGGQTVIQAYEIASFQVAAHLKCPIWMGASDGYMIVFTSGPYLLLFSITGFLLQRF

--------------------------------------------------------------

>63000_63000_19_PBRM1-FBXW12_PBRM1_chr3_52595783_ENST00000409114_FBXW12_chr3_48416844_ENST00000296438_length(amino acids)=1813AA_BP=1444
MGSKRRRATSPSSSVSGDFDDGHHSVSTPGPSRKRRRLSNLPTVDPIAVCHELYNTIRDYKDEQGRLLCELFIRAPKRRNQPDYYEVVSQ
PIDLMKIQQKLKMEEYDDVNLLTADFQLLFNNAKSYYKPDSPEYKAACKLWDLYLRTRNEFVQKGEADDEDDDEDGQDNQGTVTEGSSPA
YLKEILEQLLEAIVVATNPSGRLISELFQKLPSKVQYPDYYAIIKEPIDLKTIAQRIQNGSYKSIHAMAKDIDLLAKNAKTYNEPGSQVF
KDANSIKKIFYMKKAEIEHHEMAKSSLRMRTPSNLAAARLTGPSHSKGSLGEERNPTSKYYRNKRAVQGGRLSAITMALQYGSESEEDAA
LAAARYEEGESEAESITSFMDVSNPFYQLYDTVRSCRNNQGQLIAEPFYHLPSKKKYPDYYQQIKMPISLQQIRTKLKNQEYETLDHLEC
DLNLMFENAKRYNVPNSAIYKRVLKLQQVMQAKKKELARRDDIEDGDSMISSATSDTGSAKRKRNTHDSEMLGLRRLSSKKNIRKQRMKI
LFNVVLEAREPGSGRRLCDLFMVKPSKKDYPDYYKIILEPMDLKIIEHNIRNDKYAGEEGMIEDMKLMFRNARHYNEEGSQVYNDAHILE
KLLKEKRKELGPLPDDDDMASPKLKLSRKSGISPKKSKYMTPMQQKLNEVYEAVKNYTDKRGRRLSAIFLRLPSRSELPDYYLTIKKPMD
MEKIRSHMMANKYQDIDSMVEDFVMMFNNACTYNEPESLIYKDALVLHKVLLETRRDLEGDEDSHVPNVTLLIQELIHNLFVSVMSHQDD
EGRCYSDSLAEIPAVDPNFPNKPPLTFDIIRKNVENNRYRRLDLFQEHMFEVLERARRMNRTDSEIYEDAVELQQFFIKIRDELCKNGEI
LLSPALSYTTKHLHNDVEKERKEKLPKEIEEDKLKREEEKREAEKSEDSSGAAGLSGLHRTYSQDCSFKNSMYHVGDYVYVEPAEANLQP
HIVCIERLWEDSAGEKWLYGCWFYRPNETFHLATRKFLEKEVFKSDYYNKVPVSKILGKCVVMFVKEYFKLCPENFRDEDVFVCESRYSA
KTKSFKKIKLWTMPISSVRFVPRDVPLPVVRVASVFANADKGDDEKNTDNSEDSRAEDNFNLEKEKEDVPVEMSNGEPGCHYFEQLHYND
MWLKVGDCVFIKSHGLVRPRVGRIEKVWVRDGAAYFYGPIFIHPEETEHEPTKMFYKKEVFLSNLEETCPMTCILGKCAVLSFKDFLSCR
PTEIPENDILLCESRYNESDKQMKKFKGLKRFSLSAKVVDDEIYYFRKPIVPQKEPSPLLEKKIQLLEAKFAELEGGDDDIEEMGEEDSE
VIEPPSLPQLQTPLASELDLMPYTPPQSTPKSAKGSAKKEGSKRKINMSGYILFSSEMRAVIKAQHPDYSFGELSRLVGTEWRNLETAKK
AEYEAFETELAYLSGNRLTVDEQEKSIICSVSPKQELCAWDVQEGTMIWSSPVQEFHFSNLVTLPQMHLAITMDRKKTIKVWNCQDRDAL
AVLPMPQPCYCMEAYLTKDGPFLMVGDAAGDIYTFTLPGLRDVSKVTAFQYGIVLLHCSPDKKWVFACGTYSRTLPQVFLTESLLRPSEG
SVPLSTFLPHKLCASACWTPKVKNRITLMSQSSTGKKTEFITFDLTTKKTGGQTVIQAYEIASFQVAAHLKCPIWMGASDGYMIVFTSGP
YLLLFSITGFLLQRFEDHQAAINNFWVDPCYVLTTSENSVHVYMWEEGGRHPYLRSCCHLENTWHDHTTDSCISSVMCDNASIVLRVRKV

--------------------------------------------------------------

>63000_63000_20_PBRM1-FBXW12_PBRM1_chr3_52595783_ENST00000409114_FBXW12_chr3_48416844_ENST00000415155_length(amino acids)=1743AA_BP=1444
MGSKRRRATSPSSSVSGDFDDGHHSVSTPGPSRKRRRLSNLPTVDPIAVCHELYNTIRDYKDEQGRLLCELFIRAPKRRNQPDYYEVVSQ
PIDLMKIQQKLKMEEYDDVNLLTADFQLLFNNAKSYYKPDSPEYKAACKLWDLYLRTRNEFVQKGEADDEDDDEDGQDNQGTVTEGSSPA
YLKEILEQLLEAIVVATNPSGRLISELFQKLPSKVQYPDYYAIIKEPIDLKTIAQRIQNGSYKSIHAMAKDIDLLAKNAKTYNEPGSQVF
KDANSIKKIFYMKKAEIEHHEMAKSSLRMRTPSNLAAARLTGPSHSKGSLGEERNPTSKYYRNKRAVQGGRLSAITMALQYGSESEEDAA
LAAARYEEGESEAESITSFMDVSNPFYQLYDTVRSCRNNQGQLIAEPFYHLPSKKKYPDYYQQIKMPISLQQIRTKLKNQEYETLDHLEC
DLNLMFENAKRYNVPNSAIYKRVLKLQQVMQAKKKELARRDDIEDGDSMISSATSDTGSAKRKRNTHDSEMLGLRRLSSKKNIRKQRMKI
LFNVVLEAREPGSGRRLCDLFMVKPSKKDYPDYYKIILEPMDLKIIEHNIRNDKYAGEEGMIEDMKLMFRNARHYNEEGSQVYNDAHILE
KLLKEKRKELGPLPDDDDMASPKLKLSRKSGISPKKSKYMTPMQQKLNEVYEAVKNYTDKRGRRLSAIFLRLPSRSELPDYYLTIKKPMD
MEKIRSHMMANKYQDIDSMVEDFVMMFNNACTYNEPESLIYKDALVLHKVLLETRRDLEGDEDSHVPNVTLLIQELIHNLFVSVMSHQDD
EGRCYSDSLAEIPAVDPNFPNKPPLTFDIIRKNVENNRYRRLDLFQEHMFEVLERARRMNRTDSEIYEDAVELQQFFIKIRDELCKNGEI
LLSPALSYTTKHLHNDVEKERKEKLPKEIEEDKLKREEEKREAEKSEDSSGAAGLSGLHRTYSQDCSFKNSMYHVGDYVYVEPAEANLQP
HIVCIERLWEDSAGEKWLYGCWFYRPNETFHLATRKFLEKEVFKSDYYNKVPVSKILGKCVVMFVKEYFKLCPENFRDEDVFVCESRYSA
KTKSFKKIKLWTMPISSVRFVPRDVPLPVVRVASVFANADKGDDEKNTDNSEDSRAEDNFNLEKEKEDVPVEMSNGEPGCHYFEQLHYND
MWLKVGDCVFIKSHGLVRPRVGRIEKVWVRDGAAYFYGPIFIHPEETEHEPTKMFYKKEVFLSNLEETCPMTCILGKCAVLSFKDFLSCR
PTEIPENDILLCESRYNESDKQMKKFKGLKRFSLSAKVVDDEIYYFRKPIVPQKEPSPLLEKKIQLLEAKFAELEGGDDDIEEMGEEDSE
VIEPPSLPQLQTPLASELDLMPYTPPQSTPKSAKGSAKKEGSKRKINMSGYILFSSEMRAVIKAQHPDYSFGELSRLVGTEWRNLETAKK
AEYEAFETELAYLSGNRLTVDEQEKSIICSVSPKQELCAWDVQEVGDAAGDIYTFTLPGLRDVSKVTAFQYGIVLLHCSPDKKWVFACGT
YSRTLPQVFLTESLLRPSEGSVPLSTFLPHKLCASACWTPKVKNRITLMSQSSTGKKTEFITFDLTTKKTGGQTVIQAYEIASFQVAAHL
KCPIWMGASDGYMIVFTSGPYLLLFSITGFLLQRFEDHQAAINNFWVDPCYVLTTSENSVHVYMWEEGGRHPYLRSCCHLENTWHDHTTD

--------------------------------------------------------------

>63000_63000_21_PBRM1-FBXW12_PBRM1_chr3_52595783_ENST00000409114_FBXW12_chr3_48416844_ENST00000445170_length(amino acids)=1813AA_BP=1444
MGSKRRRATSPSSSVSGDFDDGHHSVSTPGPSRKRRRLSNLPTVDPIAVCHELYNTIRDYKDEQGRLLCELFIRAPKRRNQPDYYEVVSQ
PIDLMKIQQKLKMEEYDDVNLLTADFQLLFNNAKSYYKPDSPEYKAACKLWDLYLRTRNEFVQKGEADDEDDDEDGQDNQGTVTEGSSPA
YLKEILEQLLEAIVVATNPSGRLISELFQKLPSKVQYPDYYAIIKEPIDLKTIAQRIQNGSYKSIHAMAKDIDLLAKNAKTYNEPGSQVF
KDANSIKKIFYMKKAEIEHHEMAKSSLRMRTPSNLAAARLTGPSHSKGSLGEERNPTSKYYRNKRAVQGGRLSAITMALQYGSESEEDAA
LAAARYEEGESEAESITSFMDVSNPFYQLYDTVRSCRNNQGQLIAEPFYHLPSKKKYPDYYQQIKMPISLQQIRTKLKNQEYETLDHLEC
DLNLMFENAKRYNVPNSAIYKRVLKLQQVMQAKKKELARRDDIEDGDSMISSATSDTGSAKRKRNTHDSEMLGLRRLSSKKNIRKQRMKI
LFNVVLEAREPGSGRRLCDLFMVKPSKKDYPDYYKIILEPMDLKIIEHNIRNDKYAGEEGMIEDMKLMFRNARHYNEEGSQVYNDAHILE
KLLKEKRKELGPLPDDDDMASPKLKLSRKSGISPKKSKYMTPMQQKLNEVYEAVKNYTDKRGRRLSAIFLRLPSRSELPDYYLTIKKPMD
MEKIRSHMMANKYQDIDSMVEDFVMMFNNACTYNEPESLIYKDALVLHKVLLETRRDLEGDEDSHVPNVTLLIQELIHNLFVSVMSHQDD
EGRCYSDSLAEIPAVDPNFPNKPPLTFDIIRKNVENNRYRRLDLFQEHMFEVLERARRMNRTDSEIYEDAVELQQFFIKIRDELCKNGEI
LLSPALSYTTKHLHNDVEKERKEKLPKEIEEDKLKREEEKREAEKSEDSSGAAGLSGLHRTYSQDCSFKNSMYHVGDYVYVEPAEANLQP
HIVCIERLWEDSAGEKWLYGCWFYRPNETFHLATRKFLEKEVFKSDYYNKVPVSKILGKCVVMFVKEYFKLCPENFRDEDVFVCESRYSA
KTKSFKKIKLWTMPISSVRFVPRDVPLPVVRVASVFANADKGDDEKNTDNSEDSRAEDNFNLEKEKEDVPVEMSNGEPGCHYFEQLHYND
MWLKVGDCVFIKSHGLVRPRVGRIEKVWVRDGAAYFYGPIFIHPEETEHEPTKMFYKKEVFLSNLEETCPMTCILGKCAVLSFKDFLSCR
PTEIPENDILLCESRYNESDKQMKKFKGLKRFSLSAKVVDDEIYYFRKPIVPQKEPSPLLEKKIQLLEAKFAELEGGDDDIEEMGEEDSE
VIEPPSLPQLQTPLASELDLMPYTPPQSTPKSAKGSAKKEGSKRKINMSGYILFSSEMRAVIKAQHPDYSFGELSRLVGTEWRNLETAKK
AEYEAFETELAYLSGNRLTVDEQEKSIICSVSPKQELCAWDVQEGTMIWSSPVQEFHFSNLVTLPQMHLAITMDRKKTIKVWNCQDRDAL
AVLPMPQPCYCMEAYLTKDGPFLMVGDAAGDIYTFTLPGLRDVSKVTAFQYGIVLLHCSPDKKWVFACGTYSRTLPQVFLTESLLRPSEG
SVPLSTFLPHKLCASACWTPKVKNRITLMSQSSTGKKTEFITFDLTTKKTGGQTVIQAYEIASFQVAAHLKCPIWMGASDGYMIVFTSGP
YLLLFSITGFLLQRFEDHQAAINNFWVDPCYVLTTSENSVHVYMWEEGGRHPYLRSCCHLENTWHDHTTDSCISSVMCDNASIVLRVRKV

--------------------------------------------------------------

>63000_63000_22_PBRM1-FBXW12_PBRM1_chr3_52595783_ENST00000409767_FBXW12_chr3_48416844_ENST00000296438_length(amino acids)=1813AA_BP=1444
MGSKRRRATSPSSSVSGDFDDGHHSVSTPGPSRKRRRLSNLPTVDPIAVCHELYNTIRDYKDEQGRLLCELFIRAPKRRNQPDYYEVVSQ
PIDLMKIQQKLKMEEYDDVNLLTADFQLLFNNAKSYYKPDSPEYKAACKLWDLYLRTRNEFVQKGEADDEDDDEDGQDNQGTVTEGSSPA
YLKEILEQLLEAIVVATNPSGRLISELFQKLPSKVQYPDYYAIIKEPIDLKTIAQRIQNGSYKSIHAMAKDIDLLAKNAKTYNEPGSQVF
KDANSIKKIFYMKKAEIEHHEMAKSSLRMRTPSNLAAARLTGPSHSKGSLGEERNPTSKYYRNKRAVQGGRLSAITMALQYGSESEEDAA
LAAARYEEGESEAESITSFMDVSNPFYQLYDTVRSCRNNQGQLIAEPFYHLPSKKKYPDYYQQIKMPISLQQIRTKLKNQEYETLDHLEC
DLNLMFENAKRYNVPNSAIYKRVLKLQQVMQAKKKELARRDDIEDGDSMISSATSDTGSAKRKRNTHDSEMLGLRRLSSKKNIRKQRMKI
LFNVVLEAREPGSGRRLCDLFMVKPSKKDYPDYYKIILEPMDLKIIEHNIRNDKYAGEEGMIEDMKLMFRNARHYNEEGSQVYNDAHILE
KLLKEKRKELGPLPDDDDMASPKLKLSRKSGISPKKSKYMTPMQQKLNEVYEAVKNYTDKRGRRLSAIFLRLPSRSELPDYYLTIKKPMD
MEKIRSHMMANKYQDIDSMVEDFVMMFNNACTYNEPESLIYKDALVLHKVLLETRRDLEGDEDSHVPNVTLLIQELIHNLFVSVMSHQDD
EGRCYSDSLAEIPAVDPNFPNKPPLTFDIIRKNVENNRYRRLDLFQEHMFEVLERARRMNRTDSEIYEDAVELQQFFIKIRDELCKNGEI
LLSPALSYTTKHLHNDVEKERKEKLPKEIEEDKLKREEEKREAEKSEDSSGAAGLSGLHRTYSQDCSFKNSMYHVGDYVYVEPAEANLQP
HIVCIERLWEDSAGEKWLYGCWFYRPNETFHLATRKFLEKEVFKSDYYNKVPVSKILGKCVVMFVKEYFKLCPENFRDEDVFVCESRYSA
KTKSFKKIKLWTMPISSVRFVPRDVPLPVVRVASVFANADKGDDEKNTDNSEDSRAEDNFNLEKEKEDVPVEMSNGEPGCHYFEQLHYND
MWLKVGDCVFIKSHGLVRPRVGRIEKVWVRDGAAYFYGPIFIHPEETEHEPTKMFYKKEVFLSNLEETCPMTCILGKCAVLSFKDFLSCR
PTEIPENDILLCESRYNESDKQMKKFKGLKRFSLSAKVVDDEIYYFRKPIVPQKEPSPLLEKKIQLLEAKFAELEGGDDDIEEMGEEDSE
VIEPPSLPQLQTPLASELDLMPYTPPQSTPKSAKGSAKKEGSKRKINMSGYILFSSEMRAVIKAQHPDYSFGELSRLVGTEWRNLETAKK
AEYEAFETELAYLSGNRLTVDEQEKSIICSVSPKQELCAWDVQEGTMIWSSPVQEFHFSNLVTLPQMHLAITMDRKKTIKVWNCQDRDAL
AVLPMPQPCYCMEAYLTKDGPFLMVGDAAGDIYTFTLPGLRDVSKVTAFQYGIVLLHCSPDKKWVFACGTYSRTLPQVFLTESLLRPSEG
SVPLSTFLPHKLCASACWTPKVKNRITLMSQSSTGKKTEFITFDLTTKKTGGQTVIQAYEIASFQVAAHLKCPIWMGASDGYMIVFTSGP
YLLLFSITGFLLQRFEDHQAAINNFWVDPCYVLTTSENSVHVYMWEEGGRHPYLRSCCHLENTWHDHTTDSCISSVMCDNASIVLRVRKV

--------------------------------------------------------------

>63000_63000_23_PBRM1-FBXW12_PBRM1_chr3_52595783_ENST00000409767_FBXW12_chr3_48416844_ENST00000415155_length(amino acids)=1743AA_BP=1444
MGSKRRRATSPSSSVSGDFDDGHHSVSTPGPSRKRRRLSNLPTVDPIAVCHELYNTIRDYKDEQGRLLCELFIRAPKRRNQPDYYEVVSQ
PIDLMKIQQKLKMEEYDDVNLLTADFQLLFNNAKSYYKPDSPEYKAACKLWDLYLRTRNEFVQKGEADDEDDDEDGQDNQGTVTEGSSPA
YLKEILEQLLEAIVVATNPSGRLISELFQKLPSKVQYPDYYAIIKEPIDLKTIAQRIQNGSYKSIHAMAKDIDLLAKNAKTYNEPGSQVF
KDANSIKKIFYMKKAEIEHHEMAKSSLRMRTPSNLAAARLTGPSHSKGSLGEERNPTSKYYRNKRAVQGGRLSAITMALQYGSESEEDAA
LAAARYEEGESEAESITSFMDVSNPFYQLYDTVRSCRNNQGQLIAEPFYHLPSKKKYPDYYQQIKMPISLQQIRTKLKNQEYETLDHLEC
DLNLMFENAKRYNVPNSAIYKRVLKLQQVMQAKKKELARRDDIEDGDSMISSATSDTGSAKRKRNTHDSEMLGLRRLSSKKNIRKQRMKI
LFNVVLEAREPGSGRRLCDLFMVKPSKKDYPDYYKIILEPMDLKIIEHNIRNDKYAGEEGMIEDMKLMFRNARHYNEEGSQVYNDAHILE
KLLKEKRKELGPLPDDDDMASPKLKLSRKSGISPKKSKYMTPMQQKLNEVYEAVKNYTDKRGRRLSAIFLRLPSRSELPDYYLTIKKPMD
MEKIRSHMMANKYQDIDSMVEDFVMMFNNACTYNEPESLIYKDALVLHKVLLETRRDLEGDEDSHVPNVTLLIQELIHNLFVSVMSHQDD
EGRCYSDSLAEIPAVDPNFPNKPPLTFDIIRKNVENNRYRRLDLFQEHMFEVLERARRMNRTDSEIYEDAVELQQFFIKIRDELCKNGEI
LLSPALSYTTKHLHNDVEKERKEKLPKEIEEDKLKREEEKREAEKSEDSSGAAGLSGLHRTYSQDCSFKNSMYHVGDYVYVEPAEANLQP
HIVCIERLWEDSAGEKWLYGCWFYRPNETFHLATRKFLEKEVFKSDYYNKVPVSKILGKCVVMFVKEYFKLCPENFRDEDVFVCESRYSA
KTKSFKKIKLWTMPISSVRFVPRDVPLPVVRVASVFANADKGDDEKNTDNSEDSRAEDNFNLEKEKEDVPVEMSNGEPGCHYFEQLHYND
MWLKVGDCVFIKSHGLVRPRVGRIEKVWVRDGAAYFYGPIFIHPEETEHEPTKMFYKKEVFLSNLEETCPMTCILGKCAVLSFKDFLSCR
PTEIPENDILLCESRYNESDKQMKKFKGLKRFSLSAKVVDDEIYYFRKPIVPQKEPSPLLEKKIQLLEAKFAELEGGDDDIEEMGEEDSE
VIEPPSLPQLQTPLASELDLMPYTPPQSTPKSAKGSAKKEGSKRKINMSGYILFSSEMRAVIKAQHPDYSFGELSRLVGTEWRNLETAKK
AEYEAFETELAYLSGNRLTVDEQEKSIICSVSPKQELCAWDVQEVGDAAGDIYTFTLPGLRDVSKVTAFQYGIVLLHCSPDKKWVFACGT
YSRTLPQVFLTESLLRPSEGSVPLSTFLPHKLCASACWTPKVKNRITLMSQSSTGKKTEFITFDLTTKKTGGQTVIQAYEIASFQVAAHL
KCPIWMGASDGYMIVFTSGPYLLLFSITGFLLQRFEDHQAAINNFWVDPCYVLTTSENSVHVYMWEEGGRHPYLRSCCHLENTWHDHTTD

--------------------------------------------------------------

>63000_63000_24_PBRM1-FBXW12_PBRM1_chr3_52595783_ENST00000409767_FBXW12_chr3_48416844_ENST00000445170_length(amino acids)=1813AA_BP=1444
MGSKRRRATSPSSSVSGDFDDGHHSVSTPGPSRKRRRLSNLPTVDPIAVCHELYNTIRDYKDEQGRLLCELFIRAPKRRNQPDYYEVVSQ
PIDLMKIQQKLKMEEYDDVNLLTADFQLLFNNAKSYYKPDSPEYKAACKLWDLYLRTRNEFVQKGEADDEDDDEDGQDNQGTVTEGSSPA
YLKEILEQLLEAIVVATNPSGRLISELFQKLPSKVQYPDYYAIIKEPIDLKTIAQRIQNGSYKSIHAMAKDIDLLAKNAKTYNEPGSQVF
KDANSIKKIFYMKKAEIEHHEMAKSSLRMRTPSNLAAARLTGPSHSKGSLGEERNPTSKYYRNKRAVQGGRLSAITMALQYGSESEEDAA
LAAARYEEGESEAESITSFMDVSNPFYQLYDTVRSCRNNQGQLIAEPFYHLPSKKKYPDYYQQIKMPISLQQIRTKLKNQEYETLDHLEC
DLNLMFENAKRYNVPNSAIYKRVLKLQQVMQAKKKELARRDDIEDGDSMISSATSDTGSAKRKRNTHDSEMLGLRRLSSKKNIRKQRMKI
LFNVVLEAREPGSGRRLCDLFMVKPSKKDYPDYYKIILEPMDLKIIEHNIRNDKYAGEEGMIEDMKLMFRNARHYNEEGSQVYNDAHILE
KLLKEKRKELGPLPDDDDMASPKLKLSRKSGISPKKSKYMTPMQQKLNEVYEAVKNYTDKRGRRLSAIFLRLPSRSELPDYYLTIKKPMD
MEKIRSHMMANKYQDIDSMVEDFVMMFNNACTYNEPESLIYKDALVLHKVLLETRRDLEGDEDSHVPNVTLLIQELIHNLFVSVMSHQDD
EGRCYSDSLAEIPAVDPNFPNKPPLTFDIIRKNVENNRYRRLDLFQEHMFEVLERARRMNRTDSEIYEDAVELQQFFIKIRDELCKNGEI
LLSPALSYTTKHLHNDVEKERKEKLPKEIEEDKLKREEEKREAEKSEDSSGAAGLSGLHRTYSQDCSFKNSMYHVGDYVYVEPAEANLQP
HIVCIERLWEDSAGEKWLYGCWFYRPNETFHLATRKFLEKEVFKSDYYNKVPVSKILGKCVVMFVKEYFKLCPENFRDEDVFVCESRYSA
KTKSFKKIKLWTMPISSVRFVPRDVPLPVVRVASVFANADKGDDEKNTDNSEDSRAEDNFNLEKEKEDVPVEMSNGEPGCHYFEQLHYND
MWLKVGDCVFIKSHGLVRPRVGRIEKVWVRDGAAYFYGPIFIHPEETEHEPTKMFYKKEVFLSNLEETCPMTCILGKCAVLSFKDFLSCR
PTEIPENDILLCESRYNESDKQMKKFKGLKRFSLSAKVVDDEIYYFRKPIVPQKEPSPLLEKKIQLLEAKFAELEGGDDDIEEMGEEDSE
VIEPPSLPQLQTPLASELDLMPYTPPQSTPKSAKGSAKKEGSKRKINMSGYILFSSEMRAVIKAQHPDYSFGELSRLVGTEWRNLETAKK
AEYEAFETELAYLSGNRLTVDEQEKSIICSVSPKQELCAWDVQEGTMIWSSPVQEFHFSNLVTLPQMHLAITMDRKKTIKVWNCQDRDAL
AVLPMPQPCYCMEAYLTKDGPFLMVGDAAGDIYTFTLPGLRDVSKVTAFQYGIVLLHCSPDKKWVFACGTYSRTLPQVFLTESLLRPSEG
SVPLSTFLPHKLCASACWTPKVKNRITLMSQSSTGKKTEFITFDLTTKKTGGQTVIQAYEIASFQVAAHLKCPIWMGASDGYMIVFTSGP
YLLLFSITGFLLQRFEDHQAAINNFWVDPCYVLTTSENSVHVYMWEEGGRHPYLRSCCHLENTWHDHTTDSCISSVMCDNASIVLRVRKV

--------------------------------------------------------------

>63000_63000_25_PBRM1-FBXW12_PBRM1_chr3_52595783_ENST00000410007_FBXW12_chr3_48416844_ENST00000296438_length(amino acids)=1773AA_BP=1404
MGSKRRRATSPSSSVSGDFDDGHHSVSTPGPSRKRRRLSNLPTVDPIAVCHELYNTIRDYKDEQGRLLCELFIRAPKRRNQPDYYEVVSQ
PIDLMKIQQKLKMEEYDDVNLLTADFQLLFNNAKSYYKPDSPEYKAACKLWDLYLRTRNEFVQKGEADDEDDDEDGQDNQGTVTEGSSPA
YLKEILEQLLEAIVVATNPSGRLISELFQKLPSKVQYPDYYAIIKEPIDLKTIAQRIQNGSYKSIHAMAKDIDLLAKNAKTYNEPGSQVF
KDANSIKKIFYMKKAEIEHHEMAKSSLRMRTPSNLAAARLTGPSHSKGSLGEERNPTSKYYRNKRAVQGGRLSAITMALQYGSESEEDAA
LAAARYEEGESEAESITSFMDVSNPFYQLYDTVRSCRNNQGQLIAEPFYHLPSKKKYPDYYQQIKMPISLQQIRTKLKNQEYETLDHLEC
DLNLMFENAKRYNVPNSAIYKRVLKLQQVMQAKKKELARRDDIEDGDSMISSATSDTGSAKRKSKKNIRKQRMKILFNVVLEAREPGSGR
RLCDLFMVKPSKKDYPDYYKIILEPMDLKIIEHNIRNDKYAGEEGMIEDMKLMFRNARHYNEEGSQVYNDAHILEKLLKEKRKELGPLPD
DDDMASPKLKLSRKSGISPKKSKYMTPMQQKLNEVYEAVKNYTDKRGRRLSAIFLRLPSRSELPDYYLTIKKPMDMEKIRSHMMANKYQD
IDSMVEDFVMMFNNACTYNEPESLIYKDALVLHKVLLETRRDLEGDEDSHVPNVTLLIQELIHNLFVSVMSHQDDEGRCYSDSLAEIPAV
DPNFPNKPPLTFDIIRKNVENNRYRRLDLFQEHMFEVLERARRMNRTDSEIYEDAVELQQFFIKIRDELCKNGEILLSPALSYTTKHLHN
DVEKERKEKLPKEIEEDKLKREEEKREAEKSEDSSGAAGLSGLHRTYSQDCSFKNSMYHVGDYVYVEPAEANLQPHIVCIERLWEDSAEK
EVFKSDYYNKVPVSKILGKCVVMFVKEYFKLCPENFRDEDVFVCESRYSAKTKSFKKIKLWTMPISSVRFVPRDVPLPVVRVASVFANAD
KGDDEKNTDNSEDSRAEDNFNLEKEKEDVPVEMSNGEPGCHYFEQLHYNDMWLKVGDCVFIKSHGLVRPRVGRIEKVWVRDGAAYFYGPI
FIHPEETEHEPTKMFYKKEVFLSNLEETCPMTCILGKCAVLSFKDFLSCRPTEIPENDILLCESRYNESDKQMKKFKGLKRFSLSAKVVD
DEIYYFRKPIVPQKEPSPLLEKKIQLLEAKFAELEGGDDDIEEMGEEDSEVIEPPSLPQLQTPLASELDLMPYTPPQSTPKSAKGSAKKE
GSKRKINMSGYILFSSEMRAVIKAQHPDYSFGELSRLVGTEWRNLETAKKAEYEAFETELAYLSGNRLTVDEQEKSIICSVSPKQELCAW
DVQEGTMIWSSPVQEFHFSNLVTLPQMHLAITMDRKKTIKVWNCQDRDALAVLPMPQPCYCMEAYLTKDGPFLMVGDAAGDIYTFTLPGL
RDVSKVTAFQYGIVLLHCSPDKKWVFACGTYSRTLPQVFLTESLLRPSEGSVPLSTFLPHKLCASACWTPKVKNRITLMSQSSTGKKTEF
ITFDLTTKKTGGQTVIQAYEIASFQVAAHLKCPIWMGASDGYMIVFTSGPYLLLFSITGFLLQRFEDHQAAINNFWVDPCYVLTTSENSV

--------------------------------------------------------------

>63000_63000_26_PBRM1-FBXW12_PBRM1_chr3_52595783_ENST00000410007_FBXW12_chr3_48416844_ENST00000415155_length(amino acids)=1703AA_BP=1404
MGSKRRRATSPSSSVSGDFDDGHHSVSTPGPSRKRRRLSNLPTVDPIAVCHELYNTIRDYKDEQGRLLCELFIRAPKRRNQPDYYEVVSQ
PIDLMKIQQKLKMEEYDDVNLLTADFQLLFNNAKSYYKPDSPEYKAACKLWDLYLRTRNEFVQKGEADDEDDDEDGQDNQGTVTEGSSPA
YLKEILEQLLEAIVVATNPSGRLISELFQKLPSKVQYPDYYAIIKEPIDLKTIAQRIQNGSYKSIHAMAKDIDLLAKNAKTYNEPGSQVF
KDANSIKKIFYMKKAEIEHHEMAKSSLRMRTPSNLAAARLTGPSHSKGSLGEERNPTSKYYRNKRAVQGGRLSAITMALQYGSESEEDAA
LAAARYEEGESEAESITSFMDVSNPFYQLYDTVRSCRNNQGQLIAEPFYHLPSKKKYPDYYQQIKMPISLQQIRTKLKNQEYETLDHLEC
DLNLMFENAKRYNVPNSAIYKRVLKLQQVMQAKKKELARRDDIEDGDSMISSATSDTGSAKRKSKKNIRKQRMKILFNVVLEAREPGSGR
RLCDLFMVKPSKKDYPDYYKIILEPMDLKIIEHNIRNDKYAGEEGMIEDMKLMFRNARHYNEEGSQVYNDAHILEKLLKEKRKELGPLPD
DDDMASPKLKLSRKSGISPKKSKYMTPMQQKLNEVYEAVKNYTDKRGRRLSAIFLRLPSRSELPDYYLTIKKPMDMEKIRSHMMANKYQD
IDSMVEDFVMMFNNACTYNEPESLIYKDALVLHKVLLETRRDLEGDEDSHVPNVTLLIQELIHNLFVSVMSHQDDEGRCYSDSLAEIPAV
DPNFPNKPPLTFDIIRKNVENNRYRRLDLFQEHMFEVLERARRMNRTDSEIYEDAVELQQFFIKIRDELCKNGEILLSPALSYTTKHLHN
DVEKERKEKLPKEIEEDKLKREEEKREAEKSEDSSGAAGLSGLHRTYSQDCSFKNSMYHVGDYVYVEPAEANLQPHIVCIERLWEDSAEK
EVFKSDYYNKVPVSKILGKCVVMFVKEYFKLCPENFRDEDVFVCESRYSAKTKSFKKIKLWTMPISSVRFVPRDVPLPVVRVASVFANAD
KGDDEKNTDNSEDSRAEDNFNLEKEKEDVPVEMSNGEPGCHYFEQLHYNDMWLKVGDCVFIKSHGLVRPRVGRIEKVWVRDGAAYFYGPI
FIHPEETEHEPTKMFYKKEVFLSNLEETCPMTCILGKCAVLSFKDFLSCRPTEIPENDILLCESRYNESDKQMKKFKGLKRFSLSAKVVD
DEIYYFRKPIVPQKEPSPLLEKKIQLLEAKFAELEGGDDDIEEMGEEDSEVIEPPSLPQLQTPLASELDLMPYTPPQSTPKSAKGSAKKE
GSKRKINMSGYILFSSEMRAVIKAQHPDYSFGELSRLVGTEWRNLETAKKAEYEAFETELAYLSGNRLTVDEQEKSIICSVSPKQELCAW
DVQEVGDAAGDIYTFTLPGLRDVSKVTAFQYGIVLLHCSPDKKWVFACGTYSRTLPQVFLTESLLRPSEGSVPLSTFLPHKLCASACWTP
KVKNRITLMSQSSTGKKTEFITFDLTTKKTGGQTVIQAYEIASFQVAAHLKCPIWMGASDGYMIVFTSGPYLLLFSITGFLLQRFEDHQA

--------------------------------------------------------------

>63000_63000_27_PBRM1-FBXW12_PBRM1_chr3_52595783_ENST00000410007_FBXW12_chr3_48416844_ENST00000445170_length(amino acids)=1773AA_BP=1404
MGSKRRRATSPSSSVSGDFDDGHHSVSTPGPSRKRRRLSNLPTVDPIAVCHELYNTIRDYKDEQGRLLCELFIRAPKRRNQPDYYEVVSQ
PIDLMKIQQKLKMEEYDDVNLLTADFQLLFNNAKSYYKPDSPEYKAACKLWDLYLRTRNEFVQKGEADDEDDDEDGQDNQGTVTEGSSPA
YLKEILEQLLEAIVVATNPSGRLISELFQKLPSKVQYPDYYAIIKEPIDLKTIAQRIQNGSYKSIHAMAKDIDLLAKNAKTYNEPGSQVF
KDANSIKKIFYMKKAEIEHHEMAKSSLRMRTPSNLAAARLTGPSHSKGSLGEERNPTSKYYRNKRAVQGGRLSAITMALQYGSESEEDAA
LAAARYEEGESEAESITSFMDVSNPFYQLYDTVRSCRNNQGQLIAEPFYHLPSKKKYPDYYQQIKMPISLQQIRTKLKNQEYETLDHLEC
DLNLMFENAKRYNVPNSAIYKRVLKLQQVMQAKKKELARRDDIEDGDSMISSATSDTGSAKRKSKKNIRKQRMKILFNVVLEAREPGSGR
RLCDLFMVKPSKKDYPDYYKIILEPMDLKIIEHNIRNDKYAGEEGMIEDMKLMFRNARHYNEEGSQVYNDAHILEKLLKEKRKELGPLPD
DDDMASPKLKLSRKSGISPKKSKYMTPMQQKLNEVYEAVKNYTDKRGRRLSAIFLRLPSRSELPDYYLTIKKPMDMEKIRSHMMANKYQD
IDSMVEDFVMMFNNACTYNEPESLIYKDALVLHKVLLETRRDLEGDEDSHVPNVTLLIQELIHNLFVSVMSHQDDEGRCYSDSLAEIPAV
DPNFPNKPPLTFDIIRKNVENNRYRRLDLFQEHMFEVLERARRMNRTDSEIYEDAVELQQFFIKIRDELCKNGEILLSPALSYTTKHLHN
DVEKERKEKLPKEIEEDKLKREEEKREAEKSEDSSGAAGLSGLHRTYSQDCSFKNSMYHVGDYVYVEPAEANLQPHIVCIERLWEDSAEK
EVFKSDYYNKVPVSKILGKCVVMFVKEYFKLCPENFRDEDVFVCESRYSAKTKSFKKIKLWTMPISSVRFVPRDVPLPVVRVASVFANAD
KGDDEKNTDNSEDSRAEDNFNLEKEKEDVPVEMSNGEPGCHYFEQLHYNDMWLKVGDCVFIKSHGLVRPRVGRIEKVWVRDGAAYFYGPI
FIHPEETEHEPTKMFYKKEVFLSNLEETCPMTCILGKCAVLSFKDFLSCRPTEIPENDILLCESRYNESDKQMKKFKGLKRFSLSAKVVD
DEIYYFRKPIVPQKEPSPLLEKKIQLLEAKFAELEGGDDDIEEMGEEDSEVIEPPSLPQLQTPLASELDLMPYTPPQSTPKSAKGSAKKE
GSKRKINMSGYILFSSEMRAVIKAQHPDYSFGELSRLVGTEWRNLETAKKAEYEAFETELAYLSGNRLTVDEQEKSIICSVSPKQELCAW
DVQEGTMIWSSPVQEFHFSNLVTLPQMHLAITMDRKKTIKVWNCQDRDALAVLPMPQPCYCMEAYLTKDGPFLMVGDAAGDIYTFTLPGL
RDVSKVTAFQYGIVLLHCSPDKKWVFACGTYSRTLPQVFLTESLLRPSEGSVPLSTFLPHKLCASACWTPKVKNRITLMSQSSTGKKTEF
ITFDLTTKKTGGQTVIQAYEIASFQVAAHLKCPIWMGASDGYMIVFTSGPYLLLFSITGFLLQRFEDHQAAINNFWVDPCYVLTTSENSV

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Top

Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr3:52592265/chr3:48416844)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePBRM1chr3:52592265chr3:48416844ENST00000296302-2630630_6331484.33333333333331690.0Compositional biasNote=Poly-Asp
HgenePBRM1chr3:52592265chr3:48416844ENST00000409114-2730630_6331499.33333333333331653.0Compositional biasNote=Poly-Asp
HgenePBRM1chr3:52595783chr3:48416844ENST00000296302-2530630_6331429.33333333333331690.0Compositional biasNote=Poly-Asp
HgenePBRM1chr3:52595783chr3:48416844ENST00000337303-2528630_6331429.33333333333331583.0Compositional biasNote=Poly-Asp
HgenePBRM1chr3:52595783chr3:48416844ENST00000356770-2428630_6331397.33333333333331603.0Compositional biasNote=Poly-Asp
HgenePBRM1chr3:52595783chr3:48416844ENST00000394830-2630630_6331377.33333333333331583.0Compositional biasNote=Poly-Asp
HgenePBRM1chr3:52595783chr3:48416844ENST00000409057-2529630_6331429.33333333333331635.0Compositional biasNote=Poly-Asp
HgenePBRM1chr3:52595783chr3:48416844ENST00000409114-2630630_6331444.33333333333331653.0Compositional biasNote=Poly-Asp
HgenePBRM1chr3:52595783chr3:48416844ENST00000409767-2629630_6331444.33333333333331598.0Compositional biasNote=Poly-Asp
HgenePBRM1chr3:52595783chr3:48416844ENST00000410007-2529630_6331404.33333333333331610.0Compositional biasNote=Poly-Asp
HgenePBRM1chr3:52592265chr3:48416844ENST00000296302-26301379_14471484.33333333333331690.0DNA bindingHMG box
HgenePBRM1chr3:52592265chr3:48416844ENST00000409114-27301379_14471499.33333333333331653.0DNA bindingHMG box
HgenePBRM1chr3:52595783chr3:48416844ENST00000409114-26301379_14471444.33333333333331653.0DNA bindingHMG box
HgenePBRM1chr3:52595783chr3:48416844ENST00000409767-26291379_14471444.33333333333331598.0DNA bindingHMG box
HgenePBRM1chr3:52592265chr3:48416844ENST00000296302-26301156_12721484.33333333333331690.0DomainBAH 2
HgenePBRM1chr3:52592265chr3:48416844ENST00000296302-2630200_2701484.33333333333331690.0DomainBromo 2
HgenePBRM1chr3:52592265chr3:48416844ENST00000296302-2630400_4701484.33333333333331690.0DomainBromo 3
HgenePBRM1chr3:52592265chr3:48416844ENST00000296302-2630538_6081484.33333333333331690.0DomainBromo 4
HgenePBRM1chr3:52592265chr3:48416844ENST00000296302-263064_1341484.33333333333331690.0DomainBromo 1
HgenePBRM1chr3:52592265chr3:48416844ENST00000296302-2630676_7461484.33333333333331690.0DomainBromo 5
HgenePBRM1chr3:52592265chr3:48416844ENST00000296302-2630792_8621484.33333333333331690.0DomainBromo 6
HgenePBRM1chr3:52592265chr3:48416844ENST00000296302-2630956_10741484.33333333333331690.0DomainBAH 1
HgenePBRM1chr3:52592265chr3:48416844ENST00000409114-27301156_12721499.33333333333331653.0DomainBAH 2
HgenePBRM1chr3:52592265chr3:48416844ENST00000409114-2730200_2701499.33333333333331653.0DomainBromo 2
HgenePBRM1chr3:52592265chr3:48416844ENST00000409114-2730400_4701499.33333333333331653.0DomainBromo 3
HgenePBRM1chr3:52592265chr3:48416844ENST00000409114-2730538_6081499.33333333333331653.0DomainBromo 4
HgenePBRM1chr3:52592265chr3:48416844ENST00000409114-273064_1341499.33333333333331653.0DomainBromo 1
HgenePBRM1chr3:52592265chr3:48416844ENST00000409114-2730676_7461499.33333333333331653.0DomainBromo 5
HgenePBRM1chr3:52592265chr3:48416844ENST00000409114-2730792_8621499.33333333333331653.0DomainBromo 6
HgenePBRM1chr3:52592265chr3:48416844ENST00000409114-2730956_10741499.33333333333331653.0DomainBAH 1
HgenePBRM1chr3:52595783chr3:48416844ENST00000296302-25301156_12721429.33333333333331690.0DomainBAH 2
HgenePBRM1chr3:52595783chr3:48416844ENST00000296302-2530200_2701429.33333333333331690.0DomainBromo 2
HgenePBRM1chr3:52595783chr3:48416844ENST00000296302-2530400_4701429.33333333333331690.0DomainBromo 3
HgenePBRM1chr3:52595783chr3:48416844ENST00000296302-2530538_6081429.33333333333331690.0DomainBromo 4
HgenePBRM1chr3:52595783chr3:48416844ENST00000296302-253064_1341429.33333333333331690.0DomainBromo 1
HgenePBRM1chr3:52595783chr3:48416844ENST00000296302-2530676_7461429.33333333333331690.0DomainBromo 5
HgenePBRM1chr3:52595783chr3:48416844ENST00000296302-2530792_8621429.33333333333331690.0DomainBromo 6
HgenePBRM1chr3:52595783chr3:48416844ENST00000296302-2530956_10741429.33333333333331690.0DomainBAH 1
HgenePBRM1chr3:52595783chr3:48416844ENST00000337303-25281156_12721429.33333333333331583.0DomainBAH 2
HgenePBRM1chr3:52595783chr3:48416844ENST00000337303-2528200_2701429.33333333333331583.0DomainBromo 2
HgenePBRM1chr3:52595783chr3:48416844ENST00000337303-2528400_4701429.33333333333331583.0DomainBromo 3
HgenePBRM1chr3:52595783chr3:48416844ENST00000337303-2528538_6081429.33333333333331583.0DomainBromo 4
HgenePBRM1chr3:52595783chr3:48416844ENST00000337303-252864_1341429.33333333333331583.0DomainBromo 1
HgenePBRM1chr3:52595783chr3:48416844ENST00000337303-2528676_7461429.33333333333331583.0DomainBromo 5
HgenePBRM1chr3:52595783chr3:48416844ENST00000337303-2528792_8621429.33333333333331583.0DomainBromo 6
HgenePBRM1chr3:52595783chr3:48416844ENST00000337303-2528956_10741429.33333333333331583.0DomainBAH 1
HgenePBRM1chr3:52595783chr3:48416844ENST00000356770-24281156_12721397.33333333333331603.0DomainBAH 2
HgenePBRM1chr3:52595783chr3:48416844ENST00000356770-2428200_2701397.33333333333331603.0DomainBromo 2
HgenePBRM1chr3:52595783chr3:48416844ENST00000356770-2428400_4701397.33333333333331603.0DomainBromo 3
HgenePBRM1chr3:52595783chr3:48416844ENST00000356770-2428538_6081397.33333333333331603.0DomainBromo 4
HgenePBRM1chr3:52595783chr3:48416844ENST00000356770-242864_1341397.33333333333331603.0DomainBromo 1
HgenePBRM1chr3:52595783chr3:48416844ENST00000356770-2428676_7461397.33333333333331603.0DomainBromo 5
HgenePBRM1chr3:52595783chr3:48416844ENST00000356770-2428792_8621397.33333333333331603.0DomainBromo 6
HgenePBRM1chr3:52595783chr3:48416844ENST00000356770-2428956_10741397.33333333333331603.0DomainBAH 1
HgenePBRM1chr3:52595783chr3:48416844ENST00000394830-26301156_12721377.33333333333331583.0DomainBAH 2
HgenePBRM1chr3:52595783chr3:48416844ENST00000394830-2630200_2701377.33333333333331583.0DomainBromo 2
HgenePBRM1chr3:52595783chr3:48416844ENST00000394830-2630400_4701377.33333333333331583.0DomainBromo 3
HgenePBRM1chr3:52595783chr3:48416844ENST00000394830-2630538_6081377.33333333333331583.0DomainBromo 4
HgenePBRM1chr3:52595783chr3:48416844ENST00000394830-263064_1341377.33333333333331583.0DomainBromo 1
HgenePBRM1chr3:52595783chr3:48416844ENST00000394830-2630676_7461377.33333333333331583.0DomainBromo 5
HgenePBRM1chr3:52595783chr3:48416844ENST00000394830-2630792_8621377.33333333333331583.0DomainBromo 6
HgenePBRM1chr3:52595783chr3:48416844ENST00000394830-2630956_10741377.33333333333331583.0DomainBAH 1
HgenePBRM1chr3:52595783chr3:48416844ENST00000409057-25291156_12721429.33333333333331635.0DomainBAH 2
HgenePBRM1chr3:52595783chr3:48416844ENST00000409057-2529200_2701429.33333333333331635.0DomainBromo 2
HgenePBRM1chr3:52595783chr3:48416844ENST00000409057-2529400_4701429.33333333333331635.0DomainBromo 3
HgenePBRM1chr3:52595783chr3:48416844ENST00000409057-2529538_6081429.33333333333331635.0DomainBromo 4
HgenePBRM1chr3:52595783chr3:48416844ENST00000409057-252964_1341429.33333333333331635.0DomainBromo 1
HgenePBRM1chr3:52595783chr3:48416844ENST00000409057-2529676_7461429.33333333333331635.0DomainBromo 5
HgenePBRM1chr3:52595783chr3:48416844ENST00000409057-2529792_8621429.33333333333331635.0DomainBromo 6
HgenePBRM1chr3:52595783chr3:48416844ENST00000409057-2529956_10741429.33333333333331635.0DomainBAH 1
HgenePBRM1chr3:52595783chr3:48416844ENST00000409114-26301156_12721444.33333333333331653.0DomainBAH 2
HgenePBRM1chr3:52595783chr3:48416844ENST00000409114-2630200_2701444.33333333333331653.0DomainBromo 2
HgenePBRM1chr3:52595783chr3:48416844ENST00000409114-2630400_4701444.33333333333331653.0DomainBromo 3
HgenePBRM1chr3:52595783chr3:48416844ENST00000409114-2630538_6081444.33333333333331653.0DomainBromo 4
HgenePBRM1chr3:52595783chr3:48416844ENST00000409114-263064_1341444.33333333333331653.0DomainBromo 1
HgenePBRM1chr3:52595783chr3:48416844ENST00000409114-2630676_7461444.33333333333331653.0DomainBromo 5
HgenePBRM1chr3:52595783chr3:48416844ENST00000409114-2630792_8621444.33333333333331653.0DomainBromo 6
HgenePBRM1chr3:52595783chr3:48416844ENST00000409114-2630956_10741444.33333333333331653.0DomainBAH 1
HgenePBRM1chr3:52595783chr3:48416844ENST00000409767-26291156_12721444.33333333333331598.0DomainBAH 2
HgenePBRM1chr3:52595783chr3:48416844ENST00000409767-2629200_2701444.33333333333331598.0DomainBromo 2
HgenePBRM1chr3:52595783chr3:48416844ENST00000409767-2629400_4701444.33333333333331598.0DomainBromo 3
HgenePBRM1chr3:52595783chr3:48416844ENST00000409767-2629538_6081444.33333333333331598.0DomainBromo 4
HgenePBRM1chr3:52595783chr3:48416844ENST00000409767-262964_1341444.33333333333331598.0DomainBromo 1
HgenePBRM1chr3:52595783chr3:48416844ENST00000409767-2629676_7461444.33333333333331598.0DomainBromo 5
HgenePBRM1chr3:52595783chr3:48416844ENST00000409767-2629792_8621444.33333333333331598.0DomainBromo 6
HgenePBRM1chr3:52595783chr3:48416844ENST00000409767-2629956_10741444.33333333333331598.0DomainBAH 1
HgenePBRM1chr3:52595783chr3:48416844ENST00000410007-25291156_12721404.33333333333331610.0DomainBAH 2
HgenePBRM1chr3:52595783chr3:48416844ENST00000410007-2529200_2701404.33333333333331610.0DomainBromo 2
HgenePBRM1chr3:52595783chr3:48416844ENST00000410007-2529400_4701404.33333333333331610.0DomainBromo 3
HgenePBRM1chr3:52595783chr3:48416844ENST00000410007-2529538_6081404.33333333333331610.0DomainBromo 4
HgenePBRM1chr3:52595783chr3:48416844ENST00000410007-252964_1341404.33333333333331610.0DomainBromo 1
HgenePBRM1chr3:52595783chr3:48416844ENST00000410007-2529676_7461404.33333333333331610.0DomainBromo 5
HgenePBRM1chr3:52595783chr3:48416844ENST00000410007-2529792_8621404.33333333333331610.0DomainBromo 6
HgenePBRM1chr3:52595783chr3:48416844ENST00000410007-2529956_10741404.33333333333331610.0DomainBAH 1
TgeneFBXW12chr3:52592265chr3:48416844ENST00000296438311136_17495.33333333333333465.0RepeatNote=WD 2
TgeneFBXW12chr3:52592265chr3:48416844ENST00000296438311178_21795.33333333333333465.0RepeatNote=WD 3
TgeneFBXW12chr3:52592265chr3:48416844ENST00000296438311222_26395.33333333333333465.0RepeatNote=WD 4
TgeneFBXW12chr3:52592265chr3:48416844ENST00000296438311270_31595.33333333333333465.0RepeatNote=WD 5
TgeneFBXW12chr3:52592265chr3:48416844ENST00000296438311320_36795.33333333333333465.0RepeatNote=WD 6
TgeneFBXW12chr3:52592265chr3:48416844ENST00000296438311370_40795.33333333333333465.0RepeatNote=WD 7
TgeneFBXW12chr3:52592265chr3:48416844ENST00000296438311416_46195.33333333333333465.0RepeatNote=WD 8
TgeneFBXW12chr3:52592265chr3:48416844ENST00000415155310136_17495.33333333333333395.0RepeatNote=WD 2
TgeneFBXW12chr3:52592265chr3:48416844ENST00000415155310178_21795.33333333333333395.0RepeatNote=WD 3
TgeneFBXW12chr3:52592265chr3:48416844ENST00000415155310222_26395.33333333333333395.0RepeatNote=WD 4
TgeneFBXW12chr3:52592265chr3:48416844ENST00000415155310270_31595.33333333333333395.0RepeatNote=WD 5
TgeneFBXW12chr3:52592265chr3:48416844ENST00000415155310320_36795.33333333333333395.0RepeatNote=WD 6
TgeneFBXW12chr3:52592265chr3:48416844ENST00000415155310370_40795.33333333333333395.0RepeatNote=WD 7
TgeneFBXW12chr3:52592265chr3:48416844ENST00000415155310416_46195.33333333333333395.0RepeatNote=WD 8
TgeneFBXW12chr3:52592265chr3:48416844ENST00000445170210136_17476.33333333333333446.0RepeatNote=WD 2
TgeneFBXW12chr3:52592265chr3:48416844ENST00000445170210178_21776.33333333333333446.0RepeatNote=WD 3
TgeneFBXW12chr3:52592265chr3:48416844ENST00000445170210222_26376.33333333333333446.0RepeatNote=WD 4
TgeneFBXW12chr3:52592265chr3:48416844ENST00000445170210270_31576.33333333333333446.0RepeatNote=WD 5
TgeneFBXW12chr3:52592265chr3:48416844ENST00000445170210320_36776.33333333333333446.0RepeatNote=WD 6
TgeneFBXW12chr3:52592265chr3:48416844ENST00000445170210370_40776.33333333333333446.0RepeatNote=WD 7
TgeneFBXW12chr3:52592265chr3:48416844ENST00000445170210416_46176.33333333333333446.0RepeatNote=WD 8
TgeneFBXW12chr3:52592265chr3:48416844ENST0000044517021089_13276.33333333333333446.0RepeatNote=WD 1
TgeneFBXW12chr3:52595783chr3:48416844ENST00000296438311136_17495.33333333333333465.0RepeatNote=WD 2
TgeneFBXW12chr3:52595783chr3:48416844ENST00000296438311178_21795.33333333333333465.0RepeatNote=WD 3
TgeneFBXW12chr3:52595783chr3:48416844ENST00000296438311222_26395.33333333333333465.0RepeatNote=WD 4
TgeneFBXW12chr3:52595783chr3:48416844ENST00000296438311270_31595.33333333333333465.0RepeatNote=WD 5
TgeneFBXW12chr3:52595783chr3:48416844ENST00000296438311320_36795.33333333333333465.0RepeatNote=WD 6
TgeneFBXW12chr3:52595783chr3:48416844ENST00000296438311370_40795.33333333333333465.0RepeatNote=WD 7
TgeneFBXW12chr3:52595783chr3:48416844ENST00000296438311416_46195.33333333333333465.0RepeatNote=WD 8
TgeneFBXW12chr3:52595783chr3:48416844ENST00000415155310136_17495.33333333333333395.0RepeatNote=WD 2
TgeneFBXW12chr3:52595783chr3:48416844ENST00000415155310178_21795.33333333333333395.0RepeatNote=WD 3
TgeneFBXW12chr3:52595783chr3:48416844ENST00000415155310222_26395.33333333333333395.0RepeatNote=WD 4
TgeneFBXW12chr3:52595783chr3:48416844ENST00000415155310270_31595.33333333333333395.0RepeatNote=WD 5
TgeneFBXW12chr3:52595783chr3:48416844ENST00000415155310320_36795.33333333333333395.0RepeatNote=WD 6
TgeneFBXW12chr3:52595783chr3:48416844ENST00000415155310370_40795.33333333333333395.0RepeatNote=WD 7
TgeneFBXW12chr3:52595783chr3:48416844ENST00000415155310416_46195.33333333333333395.0RepeatNote=WD 8
TgeneFBXW12chr3:52595783chr3:48416844ENST00000445170210136_17476.33333333333333446.0RepeatNote=WD 2
TgeneFBXW12chr3:52595783chr3:48416844ENST00000445170210178_21776.33333333333333446.0RepeatNote=WD 3
TgeneFBXW12chr3:52595783chr3:48416844ENST00000445170210222_26376.33333333333333446.0RepeatNote=WD 4
TgeneFBXW12chr3:52595783chr3:48416844ENST00000445170210270_31576.33333333333333446.0RepeatNote=WD 5
TgeneFBXW12chr3:52595783chr3:48416844ENST00000445170210320_36776.33333333333333446.0RepeatNote=WD 6
TgeneFBXW12chr3:52595783chr3:48416844ENST00000445170210370_40776.33333333333333446.0RepeatNote=WD 7
TgeneFBXW12chr3:52595783chr3:48416844ENST00000445170210416_46176.33333333333333446.0RepeatNote=WD 8
TgeneFBXW12chr3:52595783chr3:48416844ENST0000044517021089_13276.33333333333333446.0RepeatNote=WD 1

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePBRM1chr3:52592265chr3:48416844ENST00000296302-26301468_15991484.33333333333331690.0Compositional biasNote=Pro-rich
HgenePBRM1chr3:52592265chr3:48416844ENST00000337303-1281468_159901583.0Compositional biasNote=Pro-rich
HgenePBRM1chr3:52592265chr3:48416844ENST00000337303-128630_63301583.0Compositional biasNote=Poly-Asp
HgenePBRM1chr3:52592265chr3:48416844ENST00000356770-1281468_159901603.0Compositional biasNote=Pro-rich
HgenePBRM1chr3:52592265chr3:48416844ENST00000356770-128630_63301603.0Compositional biasNote=Poly-Asp
HgenePBRM1chr3:52592265chr3:48416844ENST00000394830-1301468_159901583.0Compositional biasNote=Pro-rich
HgenePBRM1chr3:52592265chr3:48416844ENST00000394830-130630_63301583.0Compositional biasNote=Poly-Asp
HgenePBRM1chr3:52592265chr3:48416844ENST00000409057-1291468_159901635.0Compositional biasNote=Pro-rich
HgenePBRM1chr3:52592265chr3:48416844ENST00000409057-129630_63301635.0Compositional biasNote=Poly-Asp
HgenePBRM1chr3:52592265chr3:48416844ENST00000409114-27301468_15991499.33333333333331653.0Compositional biasNote=Pro-rich
HgenePBRM1chr3:52592265chr3:48416844ENST00000409767-1291468_159901598.0Compositional biasNote=Pro-rich
HgenePBRM1chr3:52592265chr3:48416844ENST00000409767-129630_63301598.0Compositional biasNote=Poly-Asp
HgenePBRM1chr3:52592265chr3:48416844ENST00000410007-1291468_159901610.0Compositional biasNote=Pro-rich
HgenePBRM1chr3:52592265chr3:48416844ENST00000410007-129630_63301610.0Compositional biasNote=Poly-Asp
HgenePBRM1chr3:52595783chr3:48416844ENST00000296302-25301468_15991429.33333333333331690.0Compositional biasNote=Pro-rich
HgenePBRM1chr3:52595783chr3:48416844ENST00000337303-25281468_15991429.33333333333331583.0Compositional biasNote=Pro-rich
HgenePBRM1chr3:52595783chr3:48416844ENST00000356770-24281468_15991397.33333333333331603.0Compositional biasNote=Pro-rich
HgenePBRM1chr3:52595783chr3:48416844ENST00000394830-26301468_15991377.33333333333331583.0Compositional biasNote=Pro-rich
HgenePBRM1chr3:52595783chr3:48416844ENST00000409057-25291468_15991429.33333333333331635.0Compositional biasNote=Pro-rich
HgenePBRM1chr3:52595783chr3:48416844ENST00000409114-26301468_15991444.33333333333331653.0Compositional biasNote=Pro-rich
HgenePBRM1chr3:52595783chr3:48416844ENST00000409767-26291468_15991444.33333333333331598.0Compositional biasNote=Pro-rich
HgenePBRM1chr3:52595783chr3:48416844ENST00000410007-25291468_15991404.33333333333331610.0Compositional biasNote=Pro-rich
HgenePBRM1chr3:52592265chr3:48416844ENST00000337303-1281379_144701583.0DNA bindingHMG box
HgenePBRM1chr3:52592265chr3:48416844ENST00000356770-1281379_144701603.0DNA bindingHMG box
HgenePBRM1chr3:52592265chr3:48416844ENST00000394830-1301379_144701583.0DNA bindingHMG box
HgenePBRM1chr3:52592265chr3:48416844ENST00000409057-1291379_144701635.0DNA bindingHMG box
HgenePBRM1chr3:52592265chr3:48416844ENST00000409767-1291379_144701598.0DNA bindingHMG box
HgenePBRM1chr3:52592265chr3:48416844ENST00000410007-1291379_144701610.0DNA bindingHMG box
HgenePBRM1chr3:52595783chr3:48416844ENST00000296302-25301379_14471429.33333333333331690.0DNA bindingHMG box
HgenePBRM1chr3:52595783chr3:48416844ENST00000337303-25281379_14471429.33333333333331583.0DNA bindingHMG box
HgenePBRM1chr3:52595783chr3:48416844ENST00000356770-24281379_14471397.33333333333331603.0DNA bindingHMG box
HgenePBRM1chr3:52595783chr3:48416844ENST00000394830-26301379_14471377.33333333333331583.0DNA bindingHMG box
HgenePBRM1chr3:52595783chr3:48416844ENST00000409057-25291379_14471429.33333333333331635.0DNA bindingHMG box
HgenePBRM1chr3:52595783chr3:48416844ENST00000410007-25291379_14471404.33333333333331610.0DNA bindingHMG box
HgenePBRM1chr3:52592265chr3:48416844ENST00000337303-1281156_127201583.0DomainBAH 2
HgenePBRM1chr3:52592265chr3:48416844ENST00000337303-128200_27001583.0DomainBromo 2
HgenePBRM1chr3:52592265chr3:48416844ENST00000337303-128400_47001583.0DomainBromo 3
HgenePBRM1chr3:52592265chr3:48416844ENST00000337303-128538_60801583.0DomainBromo 4
HgenePBRM1chr3:52592265chr3:48416844ENST00000337303-12864_13401583.0DomainBromo 1
HgenePBRM1chr3:52592265chr3:48416844ENST00000337303-128676_74601583.0DomainBromo 5
HgenePBRM1chr3:52592265chr3:48416844ENST00000337303-128792_86201583.0DomainBromo 6
HgenePBRM1chr3:52592265chr3:48416844ENST00000337303-128956_107401583.0DomainBAH 1
HgenePBRM1chr3:52592265chr3:48416844ENST00000356770-1281156_127201603.0DomainBAH 2
HgenePBRM1chr3:52592265chr3:48416844ENST00000356770-128200_27001603.0DomainBromo 2
HgenePBRM1chr3:52592265chr3:48416844ENST00000356770-128400_47001603.0DomainBromo 3
HgenePBRM1chr3:52592265chr3:48416844ENST00000356770-128538_60801603.0DomainBromo 4
HgenePBRM1chr3:52592265chr3:48416844ENST00000356770-12864_13401603.0DomainBromo 1
HgenePBRM1chr3:52592265chr3:48416844ENST00000356770-128676_74601603.0DomainBromo 5
HgenePBRM1chr3:52592265chr3:48416844ENST00000356770-128792_86201603.0DomainBromo 6
HgenePBRM1chr3:52592265chr3:48416844ENST00000356770-128956_107401603.0DomainBAH 1
HgenePBRM1chr3:52592265chr3:48416844ENST00000394830-1301156_127201583.0DomainBAH 2
HgenePBRM1chr3:52592265chr3:48416844ENST00000394830-130200_27001583.0DomainBromo 2
HgenePBRM1chr3:52592265chr3:48416844ENST00000394830-130400_47001583.0DomainBromo 3
HgenePBRM1chr3:52592265chr3:48416844ENST00000394830-130538_60801583.0DomainBromo 4
HgenePBRM1chr3:52592265chr3:48416844ENST00000394830-13064_13401583.0DomainBromo 1
HgenePBRM1chr3:52592265chr3:48416844ENST00000394830-130676_74601583.0DomainBromo 5
HgenePBRM1chr3:52592265chr3:48416844ENST00000394830-130792_86201583.0DomainBromo 6
HgenePBRM1chr3:52592265chr3:48416844ENST00000394830-130956_107401583.0DomainBAH 1
HgenePBRM1chr3:52592265chr3:48416844ENST00000409057-1291156_127201635.0DomainBAH 2
HgenePBRM1chr3:52592265chr3:48416844ENST00000409057-129200_27001635.0DomainBromo 2
HgenePBRM1chr3:52592265chr3:48416844ENST00000409057-129400_47001635.0DomainBromo 3
HgenePBRM1chr3:52592265chr3:48416844ENST00000409057-129538_60801635.0DomainBromo 4
HgenePBRM1chr3:52592265chr3:48416844ENST00000409057-12964_13401635.0DomainBromo 1
HgenePBRM1chr3:52592265chr3:48416844ENST00000409057-129676_74601635.0DomainBromo 5
HgenePBRM1chr3:52592265chr3:48416844ENST00000409057-129792_86201635.0DomainBromo 6
HgenePBRM1chr3:52592265chr3:48416844ENST00000409057-129956_107401635.0DomainBAH 1
HgenePBRM1chr3:52592265chr3:48416844ENST00000409767-1291156_127201598.0DomainBAH 2
HgenePBRM1chr3:52592265chr3:48416844ENST00000409767-129200_27001598.0DomainBromo 2
HgenePBRM1chr3:52592265chr3:48416844ENST00000409767-129400_47001598.0DomainBromo 3
HgenePBRM1chr3:52592265chr3:48416844ENST00000409767-129538_60801598.0DomainBromo 4
HgenePBRM1chr3:52592265chr3:48416844ENST00000409767-12964_13401598.0DomainBromo 1
HgenePBRM1chr3:52592265chr3:48416844ENST00000409767-129676_74601598.0DomainBromo 5
HgenePBRM1chr3:52592265chr3:48416844ENST00000409767-129792_86201598.0DomainBromo 6
HgenePBRM1chr3:52592265chr3:48416844ENST00000409767-129956_107401598.0DomainBAH 1
HgenePBRM1chr3:52592265chr3:48416844ENST00000410007-1291156_127201610.0DomainBAH 2
HgenePBRM1chr3:52592265chr3:48416844ENST00000410007-129200_27001610.0DomainBromo 2
HgenePBRM1chr3:52592265chr3:48416844ENST00000410007-129400_47001610.0DomainBromo 3
HgenePBRM1chr3:52592265chr3:48416844ENST00000410007-129538_60801610.0DomainBromo 4
HgenePBRM1chr3:52592265chr3:48416844ENST00000410007-12964_13401610.0DomainBromo 1
HgenePBRM1chr3:52592265chr3:48416844ENST00000410007-129676_74601610.0DomainBromo 5
HgenePBRM1chr3:52592265chr3:48416844ENST00000410007-129792_86201610.0DomainBromo 6
HgenePBRM1chr3:52592265chr3:48416844ENST00000410007-129956_107401610.0DomainBAH 1
TgeneFBXW12chr3:52592265chr3:48416844ENST000002964383111_4595.33333333333333465.0DomainF-box
TgeneFBXW12chr3:52592265chr3:48416844ENST000004151553101_4595.33333333333333395.0DomainF-box
TgeneFBXW12chr3:52592265chr3:48416844ENST000004451702101_4576.33333333333333446.0DomainF-box
TgeneFBXW12chr3:52595783chr3:48416844ENST000002964383111_4595.33333333333333465.0DomainF-box
TgeneFBXW12chr3:52595783chr3:48416844ENST000004151553101_4595.33333333333333395.0DomainF-box
TgeneFBXW12chr3:52595783chr3:48416844ENST000004451702101_4576.33333333333333446.0DomainF-box
TgeneFBXW12chr3:52592265chr3:48416844ENST0000029643831189_13295.33333333333333465.0RepeatNote=WD 1
TgeneFBXW12chr3:52592265chr3:48416844ENST0000041515531089_13295.33333333333333395.0RepeatNote=WD 1
TgeneFBXW12chr3:52595783chr3:48416844ENST0000029643831189_13295.33333333333333465.0RepeatNote=WD 1
TgeneFBXW12chr3:52595783chr3:48416844ENST0000041515531089_13295.33333333333333395.0RepeatNote=WD 1


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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
PBRM1
FBXW12


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to PBRM1-FBXW12


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to PBRM1-FBXW12


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource