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	Fusion Gene Summary
	Fusion Gene Sample Information
	Fusion ORF Analysis
	Fusion Amino Acid Sequences
	Fusion Protein Functional Features
	Fusion Protein-Protein Interaction
	Related drugs with this fusion protein
	Related disease with this fusion protein

Fusion Protein:PBRM1-NEK4

Fusion Protein Summary

Fusion gene summary

Fusion partner gene information	Fusion gene name: PBRM1-NEK4
	FusionPDB ID: 63006
	FusionGDB2.0 ID: 63006
		Hgene	Tgene
	Gene symbol	PBRM1	NEK4
	Gene ID	55193	6787
	Gene name	polybromo 1	NIMA related kinase 4
	Synonyms	BAF180\|PB1	NRK2\|STK2\|pp12301
	Cytomap	3p21.1	3p21.1
	Type of gene	protein-coding	protein-coding
	Description	protein polybromo-1BRG1-associated factor 180polybromo-1D	serine/threonine-protein kinase Nek4NIMA (never in mitosis gene a)-related kinase 4never in mitosis A-related kinase 4nimA-related protein kinase 4serine/threonine kinase 2serine/threonine protein kinase-2serine/threonine-protein kinase NRK2serine/
	Modification date	20200313	20200313
	UniProtAcc	.	P51957
Ensembl transtripts involved in fusion gene	ENST ids	ENST00000296302, ENST00000337303, ENST00000356770, ENST00000394830, ENST00000409057, ENST00000409114, ENST00000409767, ENST00000410007,	ENST00000233027, ENST00000383721, ENST00000535191,
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)	* DoF score	15 X 15 X 10=2250	5 X 5 X 4=100
	# samples	19	5
	** MAII score	log2(19/2250*10)=-3.56585367777345 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(5/100*10)=-1 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)	PubMed: PBRM1 [Title/Abstract] AND NEK4 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)	PBRM1(52637537)-NEK4(52773650), # samples:3
Anticipated loss of major functional domain due to fusion event.	PBRM1-NEK4 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. PBRM1-NEK4 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. PBRM1-NEK4 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. PBRM1-NEK4 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. PBRM1-NEK4 seems lost the major protein functional domain in Hgene partner, which is a CGC due to the frame-shifted ORF. PBRM1-NEK4 seems lost the major protein functional domain in Hgene partner, which is a epigenetic factor due to the frame-shifted ORF. PBRM1-NEK4 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF. PBRM1-NEK4 seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF. PBRM1-NEK4 seems lost the major protein functional domain in Hgene partner, which is a tumor suppressor due to the frame-shifted ORF. PBRM1-NEK4 seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF. PBRM1-NEK4 seems lost the major protein functional domain in Tgene partner, which is a kinase due to the frame-shifted ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Fusion gene breakpoints across PBRM1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across NEK4 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

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Fusion Gene Sample Information

Fusion gene information from FusionGDB2.0.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	SKCM	TCGA-EB-A5SE-01A	PBRM1	chr3	52637537	-	NEK4	chr3	52773650	-
ChimerDB4	SKCM	TCGA-EB-A5SE-01A	PBRM1	chr3	52643329	-	NEK4	chr3	52773650	-

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Fusion ORF Analysis

Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000356770	PBRM1	chr3	52643329	-	ENST00000233027	NEK4	chr3	52773650	-	3900	2474	3	2906	967
ENST00000356770	PBRM1	chr3	52643329	-	ENST00000535191	NEK4	chr3	52773650	-	3091	2474	3	2906	967
ENST00000356770	PBRM1	chr3	52643329	-	ENST00000383721	NEK4	chr3	52773650	-	2902	2474	3	2864	953
ENST00000296302	PBRM1	chr3	52643329	-	ENST00000233027	NEK4	chr3	52773650	-	3995	2569	2	3001	999
ENST00000296302	PBRM1	chr3	52643329	-	ENST00000535191	NEK4	chr3	52773650	-	3186	2569	2	3001	999
ENST00000296302	PBRM1	chr3	52643329	-	ENST00000383721	NEK4	chr3	52773650	-	2997	2569	2	2959	985
ENST00000337303	PBRM1	chr3	52643329	-	ENST00000233027	NEK4	chr3	52773650	-	3996	2570	3	3002	999
ENST00000337303	PBRM1	chr3	52643329	-	ENST00000535191	NEK4	chr3	52773650	-	3187	2570	3	3002	999
ENST00000337303	PBRM1	chr3	52643329	-	ENST00000383721	NEK4	chr3	52773650	-	2998	2570	3	2960	985
ENST00000410007	PBRM1	chr3	52643329	-	ENST00000233027	NEK4	chr3	52773650	-	3996	2570	3	3002	999
ENST00000410007	PBRM1	chr3	52643329	-	ENST00000535191	NEK4	chr3	52773650	-	3187	2570	3	3002	999
ENST00000410007	PBRM1	chr3	52643329	-	ENST00000383721	NEK4	chr3	52773650	-	2998	2570	3	2960	985
ENST00000409057	PBRM1	chr3	52643329	-	ENST00000233027	NEK4	chr3	52773650	-	3996	2570	3	3002	999
ENST00000409057	PBRM1	chr3	52643329	-	ENST00000535191	NEK4	chr3	52773650	-	3187	2570	3	3002	999
ENST00000409057	PBRM1	chr3	52643329	-	ENST00000383721	NEK4	chr3	52773650	-	2998	2570	3	2960	985
ENST00000409114	PBRM1	chr3	52643329	-	ENST00000233027	NEK4	chr3	52773650	-	4041	2615	3	3047	1014
ENST00000409114	PBRM1	chr3	52643329	-	ENST00000535191	NEK4	chr3	52773650	-	3232	2615	3	3047	1014
ENST00000409114	PBRM1	chr3	52643329	-	ENST00000383721	NEK4	chr3	52773650	-	3043	2615	3	3005	1000
ENST00000409767	PBRM1	chr3	52643329	-	ENST00000233027	NEK4	chr3	52773650	-	4041	2615	3	3047	1014
ENST00000409767	PBRM1	chr3	52643329	-	ENST00000535191	NEK4	chr3	52773650	-	3232	2615	3	3047	1014
ENST00000409767	PBRM1	chr3	52643329	-	ENST00000383721	NEK4	chr3	52773650	-	3043	2615	3	3005	1000

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000356770	ENST00000233027	PBRM1	chr3	52643329	-	NEK4	chr3	52773650	-	0.00020005	0.9998
ENST00000356770	ENST00000535191	PBRM1	chr3	52643329	-	NEK4	chr3	52773650	-	0.000809265	0.99919075
ENST00000356770	ENST00000383721	PBRM1	chr3	52643329	-	NEK4	chr3	52773650	-	0.000912669	0.99908733
ENST00000296302	ENST00000233027	PBRM1	chr3	52643329	-	NEK4	chr3	52773650	-	0.000170851	0.9998292
ENST00000296302	ENST00000535191	PBRM1	chr3	52643329	-	NEK4	chr3	52773650	-	0.000728157	0.9992718
ENST00000296302	ENST00000383721	PBRM1	chr3	52643329	-	NEK4	chr3	52773650	-	0.000803969	0.999196
ENST00000337303	ENST00000233027	PBRM1	chr3	52643329	-	NEK4	chr3	52773650	-	0.0001715	0.99982846
ENST00000337303	ENST00000535191	PBRM1	chr3	52643329	-	NEK4	chr3	52773650	-	0.000733261	0.9992667
ENST00000337303	ENST00000383721	PBRM1	chr3	52643329	-	NEK4	chr3	52773650	-	0.000810459	0.99918956
ENST00000410007	ENST00000233027	PBRM1	chr3	52643329	-	NEK4	chr3	52773650	-	0.0001715	0.99982846
ENST00000410007	ENST00000535191	PBRM1	chr3	52643329	-	NEK4	chr3	52773650	-	0.000733261	0.9992667
ENST00000410007	ENST00000383721	PBRM1	chr3	52643329	-	NEK4	chr3	52773650	-	0.000810459	0.99918956
ENST00000409057	ENST00000233027	PBRM1	chr3	52643329	-	NEK4	chr3	52773650	-	0.0001715	0.99982846
ENST00000409057	ENST00000535191	PBRM1	chr3	52643329	-	NEK4	chr3	52773650	-	0.000733261	0.9992667
ENST00000409057	ENST00000383721	PBRM1	chr3	52643329	-	NEK4	chr3	52773650	-	0.000810459	0.99918956
ENST00000409114	ENST00000233027	PBRM1	chr3	52643329	-	NEK4	chr3	52773650	-	0.000457984	0.999542
ENST00000409114	ENST00000535191	PBRM1	chr3	52643329	-	NEK4	chr3	52773650	-	0.001910736	0.99808925
ENST00000409114	ENST00000383721	PBRM1	chr3	52643329	-	NEK4	chr3	52773650	-	0.001082993	0.998917
ENST00000409767	ENST00000233027	PBRM1	chr3	52643329	-	NEK4	chr3	52773650	-	0.000457984	0.999542
ENST00000409767	ENST00000535191	PBRM1	chr3	52643329	-	NEK4	chr3	52773650	-	0.001910736	0.99808925
ENST00000409767	ENST00000383721	PBRM1	chr3	52643329	-	NEK4	chr3	52773650	-	0.001082993	0.998917

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Fusion Amino Acid Sequences

For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>63006_63006_1_PBRM1-NEK4_PBRM1_chr3_52643329_ENST00000296302_NEK4_chr3_52773650_ENST00000233027_length(amino acids)=999AA_BP=855
MGSKRRRATSPSSSVSGDFDDGHHSVSTPGPSRKRRRLSNLPTVDPIAVCHELYNTIRDYKDEQGRLLCELFIRAPKRRNQPDYYEVVSQ
PIDLMKIQQKLKMEEYDDVNLLTADFQLLFNNAKSYYKPDSPEYKAACKLWDLYLRTRNEFVQKGEADDEDDDEDGQDNQGTVTEGSSPA
YLKEILEQLLEAIVVATNPSGRLISELFQKLPSKVQYPDYYAIIKEPIDLKTIAQRIQNGSYKSIHAMAKDIDLLAKNAKTYNEPGSQVF
KDANSIKKIFYMKKAEIEHHEMAKSSLRMRTPSNLAAARLTGPSHSKGSLGEERNPTSKYYRNKRAVQGGRLSAITMALQYGSESEEDAA
LAAARYEEGESEAESITSFMDVSNPFYQLYDTVRSCRNNQGQLIAEPFYHLPSKKKYPDYYQQIKMPISLQQIRTKLKNQEYETLDHLEC
DLNLMFENAKRYNVPNSAIYKRVLKLQQVMQAKKKELARRDDIEDGDSMISSATSDTGSAKRKSKKNIRKQRMKILFNVVLEAREPGSGR
RLCDLFMVKPSKKDYPDYYKIILEPMDLKIIEHNIRNDKYAGEEGMIEDMKLMFRNARHYNEEGSQVYNDAHILEKLLKEKRKELGPLPD
DDDMASPKLKLSRKSGISPKKSKYMTPMQQKLNEVYEAVKNYTDKRGRRLSAIFLRLPSRSELPDYYLTIKKPMDMEKIRSHMMANKYQD
IDSMVEDFVMMFNNACTYNEPESLIYKDALVLHKVLLETRRDLEGDEDSHVPNVTLLIQELIHNLFVSVMSHQDDEGRCYSDSLAEIPAV
DPNFPNKPPLTFDIIRKNVENNRYRRLDLFQEHMFEVLERARRMNRKGQTNEINALVQLMTQTLKLDSKESCEDVPVANPVSEFKLHRKY
RDTLILHGKVAEEAEEIHFKELPSAIMPGSEKIRRLVEVLRTDVIRGLGVQLLEQVYDLLEEEDEFDREVRLREHMGEKYTTYSVKARQL

--------------------------------------------------------------

>63006_63006_2_PBRM1-NEK4_PBRM1_chr3_52643329_ENST00000296302_NEK4_chr3_52773650_ENST00000383721_length(amino acids)=985AA_BP=855
MGSKRRRATSPSSSVSGDFDDGHHSVSTPGPSRKRRRLSNLPTVDPIAVCHELYNTIRDYKDEQGRLLCELFIRAPKRRNQPDYYEVVSQ
PIDLMKIQQKLKMEEYDDVNLLTADFQLLFNNAKSYYKPDSPEYKAACKLWDLYLRTRNEFVQKGEADDEDDDEDGQDNQGTVTEGSSPA
YLKEILEQLLEAIVVATNPSGRLISELFQKLPSKVQYPDYYAIIKEPIDLKTIAQRIQNGSYKSIHAMAKDIDLLAKNAKTYNEPGSQVF
KDANSIKKIFYMKKAEIEHHEMAKSSLRMRTPSNLAAARLTGPSHSKGSLGEERNPTSKYYRNKRAVQGGRLSAITMALQYGSESEEDAA
LAAARYEEGESEAESITSFMDVSNPFYQLYDTVRSCRNNQGQLIAEPFYHLPSKKKYPDYYQQIKMPISLQQIRTKLKNQEYETLDHLEC
DLNLMFENAKRYNVPNSAIYKRVLKLQQVMQAKKKELARRDDIEDGDSMISSATSDTGSAKRKSKKNIRKQRMKILFNVVLEAREPGSGR
RLCDLFMVKPSKKDYPDYYKIILEPMDLKIIEHNIRNDKYAGEEGMIEDMKLMFRNARHYNEEGSQVYNDAHILEKLLKEKRKELGPLPD
DDDMASPKLKLSRKSGISPKKSKYMTPMQQKLNEVYEAVKNYTDKRGRRLSAIFLRLPSRSELPDYYLTIKKPMDMEKIRSHMMANKYQD
IDSMVEDFVMMFNNACTYNEPESLIYKDALVLHKVLLETRRDLEGDEDSHVPNVTLLIQELIHNLFVSVMSHQDDEGRCYSDSLAEIPAV
DPNFPNKPPLTFDIIRKNVENNRYRRLDLFQEHMFEVLERARRMNRKGQTNEINALVQLMTQTLKLDSKESCEDVPVANPVSEFKLHRKY

--------------------------------------------------------------

>63006_63006_3_PBRM1-NEK4_PBRM1_chr3_52643329_ENST00000296302_NEK4_chr3_52773650_ENST00000535191_length(amino acids)=999AA_BP=855
MGSKRRRATSPSSSVSGDFDDGHHSVSTPGPSRKRRRLSNLPTVDPIAVCHELYNTIRDYKDEQGRLLCELFIRAPKRRNQPDYYEVVSQ
PIDLMKIQQKLKMEEYDDVNLLTADFQLLFNNAKSYYKPDSPEYKAACKLWDLYLRTRNEFVQKGEADDEDDDEDGQDNQGTVTEGSSPA
YLKEILEQLLEAIVVATNPSGRLISELFQKLPSKVQYPDYYAIIKEPIDLKTIAQRIQNGSYKSIHAMAKDIDLLAKNAKTYNEPGSQVF
KDANSIKKIFYMKKAEIEHHEMAKSSLRMRTPSNLAAARLTGPSHSKGSLGEERNPTSKYYRNKRAVQGGRLSAITMALQYGSESEEDAA
LAAARYEEGESEAESITSFMDVSNPFYQLYDTVRSCRNNQGQLIAEPFYHLPSKKKYPDYYQQIKMPISLQQIRTKLKNQEYETLDHLEC
DLNLMFENAKRYNVPNSAIYKRVLKLQQVMQAKKKELARRDDIEDGDSMISSATSDTGSAKRKSKKNIRKQRMKILFNVVLEAREPGSGR
RLCDLFMVKPSKKDYPDYYKIILEPMDLKIIEHNIRNDKYAGEEGMIEDMKLMFRNARHYNEEGSQVYNDAHILEKLLKEKRKELGPLPD
DDDMASPKLKLSRKSGISPKKSKYMTPMQQKLNEVYEAVKNYTDKRGRRLSAIFLRLPSRSELPDYYLTIKKPMDMEKIRSHMMANKYQD
IDSMVEDFVMMFNNACTYNEPESLIYKDALVLHKVLLETRRDLEGDEDSHVPNVTLLIQELIHNLFVSVMSHQDDEGRCYSDSLAEIPAV
DPNFPNKPPLTFDIIRKNVENNRYRRLDLFQEHMFEVLERARRMNRKGQTNEINALVQLMTQTLKLDSKESCEDVPVANPVSEFKLHRKY
RDTLILHGKVAEEAEEIHFKELPSAIMPGSEKIRRLVEVLRTDVIRGLGVQLLEQVYDLLEEEDEFDREVRLREHMGEKYTTYSVKARQL

--------------------------------------------------------------

>63006_63006_4_PBRM1-NEK4_PBRM1_chr3_52643329_ENST00000337303_NEK4_chr3_52773650_ENST00000233027_length(amino acids)=999AA_BP=855
MGSKRRRATSPSSSVSGDFDDGHHSVSTPGPSRKRRRLSNLPTVDPIAVCHELYNTIRDYKDEQGRLLCELFIRAPKRRNQPDYYEVVSQ
PIDLMKIQQKLKMEEYDDVNLLTADFQLLFNNAKSYYKPDSPEYKAACKLWDLYLRTRNEFVQKGEADDEDDDEDGQDNQGTVTEGSSPA
YLKEILEQLLEAIVVATNPSGRLISELFQKLPSKVQYPDYYAIIKEPIDLKTIAQRIQNGSYKSIHAMAKDIDLLAKNAKTYNEPGSQVF
KDANSIKKIFYMKKAEIEHHEMAKSSLRMRTPSNLAAARLTGPSHSKGSLGEERNPTSKYYRNKRAVQGGRLSAITMALQYGSESEEDAA
LAAARYEEGESEAESITSFMDVSNPFYQLYDTVRSCRNNQGQLIAEPFYHLPSKKKYPDYYQQIKMPISLQQIRTKLKNQEYETLDHLEC
DLNLMFENAKRYNVPNSAIYKRVLKLQQVMQAKKKELARRDDIEDGDSMISSATSDTGSAKRKSKKNIRKQRMKILFNVVLEAREPGSGR
RLCDLFMVKPSKKDYPDYYKIILEPMDLKIIEHNIRNDKYAGEEGMIEDMKLMFRNARHYNEEGSQVYNDAHILEKLLKEKRKELGPLPD
DDDMASPKLKLSRKSGISPKKSKYMTPMQQKLNEVYEAVKNYTDKRGRRLSAIFLRLPSRSELPDYYLTIKKPMDMEKIRSHMMANKYQD
IDSMVEDFVMMFNNACTYNEPESLIYKDALVLHKVLLETRRDLEGDEDSHVPNVTLLIQELIHNLFVSVMSHQDDEGRCYSDSLAEIPAV
DPNFPNKPPLTFDIIRKNVENNRYRRLDLFQEHMFEVLERARRMNRKGQTNEINALVQLMTQTLKLDSKESCEDVPVANPVSEFKLHRKY
RDTLILHGKVAEEAEEIHFKELPSAIMPGSEKIRRLVEVLRTDVIRGLGVQLLEQVYDLLEEEDEFDREVRLREHMGEKYTTYSVKARQL

--------------------------------------------------------------

>63006_63006_5_PBRM1-NEK4_PBRM1_chr3_52643329_ENST00000337303_NEK4_chr3_52773650_ENST00000383721_length(amino acids)=985AA_BP=855
MGSKRRRATSPSSSVSGDFDDGHHSVSTPGPSRKRRRLSNLPTVDPIAVCHELYNTIRDYKDEQGRLLCELFIRAPKRRNQPDYYEVVSQ
PIDLMKIQQKLKMEEYDDVNLLTADFQLLFNNAKSYYKPDSPEYKAACKLWDLYLRTRNEFVQKGEADDEDDDEDGQDNQGTVTEGSSPA
YLKEILEQLLEAIVVATNPSGRLISELFQKLPSKVQYPDYYAIIKEPIDLKTIAQRIQNGSYKSIHAMAKDIDLLAKNAKTYNEPGSQVF
KDANSIKKIFYMKKAEIEHHEMAKSSLRMRTPSNLAAARLTGPSHSKGSLGEERNPTSKYYRNKRAVQGGRLSAITMALQYGSESEEDAA
LAAARYEEGESEAESITSFMDVSNPFYQLYDTVRSCRNNQGQLIAEPFYHLPSKKKYPDYYQQIKMPISLQQIRTKLKNQEYETLDHLEC
DLNLMFENAKRYNVPNSAIYKRVLKLQQVMQAKKKELARRDDIEDGDSMISSATSDTGSAKRKSKKNIRKQRMKILFNVVLEAREPGSGR
RLCDLFMVKPSKKDYPDYYKIILEPMDLKIIEHNIRNDKYAGEEGMIEDMKLMFRNARHYNEEGSQVYNDAHILEKLLKEKRKELGPLPD
DDDMASPKLKLSRKSGISPKKSKYMTPMQQKLNEVYEAVKNYTDKRGRRLSAIFLRLPSRSELPDYYLTIKKPMDMEKIRSHMMANKYQD
IDSMVEDFVMMFNNACTYNEPESLIYKDALVLHKVLLETRRDLEGDEDSHVPNVTLLIQELIHNLFVSVMSHQDDEGRCYSDSLAEIPAV
DPNFPNKPPLTFDIIRKNVENNRYRRLDLFQEHMFEVLERARRMNRKGQTNEINALVQLMTQTLKLDSKESCEDVPVANPVSEFKLHRKY

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>63006_63006_6_PBRM1-NEK4_PBRM1_chr3_52643329_ENST00000337303_NEK4_chr3_52773650_ENST00000535191_length(amino acids)=999AA_BP=855
MGSKRRRATSPSSSVSGDFDDGHHSVSTPGPSRKRRRLSNLPTVDPIAVCHELYNTIRDYKDEQGRLLCELFIRAPKRRNQPDYYEVVSQ
PIDLMKIQQKLKMEEYDDVNLLTADFQLLFNNAKSYYKPDSPEYKAACKLWDLYLRTRNEFVQKGEADDEDDDEDGQDNQGTVTEGSSPA
YLKEILEQLLEAIVVATNPSGRLISELFQKLPSKVQYPDYYAIIKEPIDLKTIAQRIQNGSYKSIHAMAKDIDLLAKNAKTYNEPGSQVF
KDANSIKKIFYMKKAEIEHHEMAKSSLRMRTPSNLAAARLTGPSHSKGSLGEERNPTSKYYRNKRAVQGGRLSAITMALQYGSESEEDAA
LAAARYEEGESEAESITSFMDVSNPFYQLYDTVRSCRNNQGQLIAEPFYHLPSKKKYPDYYQQIKMPISLQQIRTKLKNQEYETLDHLEC
DLNLMFENAKRYNVPNSAIYKRVLKLQQVMQAKKKELARRDDIEDGDSMISSATSDTGSAKRKSKKNIRKQRMKILFNVVLEAREPGSGR
RLCDLFMVKPSKKDYPDYYKIILEPMDLKIIEHNIRNDKYAGEEGMIEDMKLMFRNARHYNEEGSQVYNDAHILEKLLKEKRKELGPLPD
DDDMASPKLKLSRKSGISPKKSKYMTPMQQKLNEVYEAVKNYTDKRGRRLSAIFLRLPSRSELPDYYLTIKKPMDMEKIRSHMMANKYQD
IDSMVEDFVMMFNNACTYNEPESLIYKDALVLHKVLLETRRDLEGDEDSHVPNVTLLIQELIHNLFVSVMSHQDDEGRCYSDSLAEIPAV
DPNFPNKPPLTFDIIRKNVENNRYRRLDLFQEHMFEVLERARRMNRKGQTNEINALVQLMTQTLKLDSKESCEDVPVANPVSEFKLHRKY
RDTLILHGKVAEEAEEIHFKELPSAIMPGSEKIRRLVEVLRTDVIRGLGVQLLEQVYDLLEEEDEFDREVRLREHMGEKYTTYSVKARQL

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>63006_63006_7_PBRM1-NEK4_PBRM1_chr3_52643329_ENST00000356770_NEK4_chr3_52773650_ENST00000233027_length(amino acids)=967AA_BP=823
MGSKRRRATSPSSSVSGDFDDGHHSVSTPGPSRKRRRLSNLPTVDPIAVCHELYNTIRDYKDEQGRLLCELFIRAPKRRNQPDYYEVVSQ
PIDLMKIQQKLKMEEYDDVNLLTADFQLLFNNAKSYYKPDSPEYKAACKLWDLYLRTRNEFVQKGEADDEDDDEDGQDNQGTVTEGSSPA
YLKEILEQLLEAIVVATNPSGRLISELFQKLPSKVQYPDYYAIIKEPIDLKTIAQRIQNGSYKSIHAMAKDIDLLAKNAKTYNEPGSQVF
KDANSIKKIFYMKKAEIEHHEMAKSSLRMSNKRAVQGGRLSAITMALQYGSESEEDAALAAARYEEGESEAESITSFMDVSNPFYQLYDT
VRSCRNNQGQLIAEPFYHLPSKKKYPDYYQQIKMPISLQQIRTKLKNQEYETLDHLECDLNLMFENAKRYNVPNSAIYKRVLKLQQVMQA
KKKELARRDDIEDGDSMISSATSDTGSAKRKSKKNIRKQRMKILFNVVLEAREPGSGRRLCDLFMVKPSKKDYPDYYKIILEPMDLKIIE
HNIRNDKYAGEEGMIEDMKLMFRNARHYNEEGSQVYNDAHILEKLLKEKRKELGPLPDDDDMASPKLKLSRKSGISPKKSKYMTPMQQKL
NEVYEAVKNYTDKRGRRLSAIFLRLPSRSELPDYYLTIKKPMDMEKIRSHMMANKYQDIDSMVEDFVMMFNNACTYNEPESLIYKDALVL
HKVLLETRRDLEGDEDSHVPNVTLLIQELIHNLFVSVMSHQDDEGRCYSDSLAEIPAVDPNFPNKPPLTFDIIRKNVENNRYRRLDLFQE
HMFEVLERARRMNRKGQTNEINALVQLMTQTLKLDSKESCEDVPVANPVSEFKLHRKYRDTLILHGKVAEEAEEIHFKELPSAIMPGSEK

--------------------------------------------------------------

>63006_63006_8_PBRM1-NEK4_PBRM1_chr3_52643329_ENST00000356770_NEK4_chr3_52773650_ENST00000383721_length(amino acids)=953AA_BP=823
MGSKRRRATSPSSSVSGDFDDGHHSVSTPGPSRKRRRLSNLPTVDPIAVCHELYNTIRDYKDEQGRLLCELFIRAPKRRNQPDYYEVVSQ
PIDLMKIQQKLKMEEYDDVNLLTADFQLLFNNAKSYYKPDSPEYKAACKLWDLYLRTRNEFVQKGEADDEDDDEDGQDNQGTVTEGSSPA
YLKEILEQLLEAIVVATNPSGRLISELFQKLPSKVQYPDYYAIIKEPIDLKTIAQRIQNGSYKSIHAMAKDIDLLAKNAKTYNEPGSQVF
KDANSIKKIFYMKKAEIEHHEMAKSSLRMSNKRAVQGGRLSAITMALQYGSESEEDAALAAARYEEGESEAESITSFMDVSNPFYQLYDT
VRSCRNNQGQLIAEPFYHLPSKKKYPDYYQQIKMPISLQQIRTKLKNQEYETLDHLECDLNLMFENAKRYNVPNSAIYKRVLKLQQVMQA
KKKELARRDDIEDGDSMISSATSDTGSAKRKSKKNIRKQRMKILFNVVLEAREPGSGRRLCDLFMVKPSKKDYPDYYKIILEPMDLKIIE
HNIRNDKYAGEEGMIEDMKLMFRNARHYNEEGSQVYNDAHILEKLLKEKRKELGPLPDDDDMASPKLKLSRKSGISPKKSKYMTPMQQKL
NEVYEAVKNYTDKRGRRLSAIFLRLPSRSELPDYYLTIKKPMDMEKIRSHMMANKYQDIDSMVEDFVMMFNNACTYNEPESLIYKDALVL
HKVLLETRRDLEGDEDSHVPNVTLLIQELIHNLFVSVMSHQDDEGRCYSDSLAEIPAVDPNFPNKPPLTFDIIRKNVENNRYRRLDLFQE
HMFEVLERARRMNRKGQTNEINALVQLMTQTLKLDSKESCEDVPVANPVSEFKLHRKYRDTLILHGKVAEEAEEIHFKELPSAIMPGSEK

--------------------------------------------------------------

>63006_63006_9_PBRM1-NEK4_PBRM1_chr3_52643329_ENST00000356770_NEK4_chr3_52773650_ENST00000535191_length(amino acids)=967AA_BP=823
MGSKRRRATSPSSSVSGDFDDGHHSVSTPGPSRKRRRLSNLPTVDPIAVCHELYNTIRDYKDEQGRLLCELFIRAPKRRNQPDYYEVVSQ
PIDLMKIQQKLKMEEYDDVNLLTADFQLLFNNAKSYYKPDSPEYKAACKLWDLYLRTRNEFVQKGEADDEDDDEDGQDNQGTVTEGSSPA
YLKEILEQLLEAIVVATNPSGRLISELFQKLPSKVQYPDYYAIIKEPIDLKTIAQRIQNGSYKSIHAMAKDIDLLAKNAKTYNEPGSQVF
KDANSIKKIFYMKKAEIEHHEMAKSSLRMSNKRAVQGGRLSAITMALQYGSESEEDAALAAARYEEGESEAESITSFMDVSNPFYQLYDT
VRSCRNNQGQLIAEPFYHLPSKKKYPDYYQQIKMPISLQQIRTKLKNQEYETLDHLECDLNLMFENAKRYNVPNSAIYKRVLKLQQVMQA
KKKELARRDDIEDGDSMISSATSDTGSAKRKSKKNIRKQRMKILFNVVLEAREPGSGRRLCDLFMVKPSKKDYPDYYKIILEPMDLKIIE
HNIRNDKYAGEEGMIEDMKLMFRNARHYNEEGSQVYNDAHILEKLLKEKRKELGPLPDDDDMASPKLKLSRKSGISPKKSKYMTPMQQKL
NEVYEAVKNYTDKRGRRLSAIFLRLPSRSELPDYYLTIKKPMDMEKIRSHMMANKYQDIDSMVEDFVMMFNNACTYNEPESLIYKDALVL
HKVLLETRRDLEGDEDSHVPNVTLLIQELIHNLFVSVMSHQDDEGRCYSDSLAEIPAVDPNFPNKPPLTFDIIRKNVENNRYRRLDLFQE
HMFEVLERARRMNRKGQTNEINALVQLMTQTLKLDSKESCEDVPVANPVSEFKLHRKYRDTLILHGKVAEEAEEIHFKELPSAIMPGSEK

--------------------------------------------------------------

>63006_63006_10_PBRM1-NEK4_PBRM1_chr3_52643329_ENST00000409057_NEK4_chr3_52773650_ENST00000233027_length(amino acids)=999AA_BP=855
MGSKRRRATSPSSSVSGDFDDGHHSVSTPGPSRKRRRLSNLPTVDPIAVCHELYNTIRDYKDEQGRLLCELFIRAPKRRNQPDYYEVVSQ
PIDLMKIQQKLKMEEYDDVNLLTADFQLLFNNAKSYYKPDSPEYKAACKLWDLYLRTRNEFVQKGEADDEDDDEDGQDNQGTVTEGSSPA
YLKEILEQLLEAIVVATNPSGRLISELFQKLPSKVQYPDYYAIIKEPIDLKTIAQRIQNGSYKSIHAMAKDIDLLAKNAKTYNEPGSQVF
KDANSIKKIFYMKKAEIEHHEMAKSSLRMRTPSNLAAARLTGPSHSKGSLGEERNPTSKYYRNKRAVQGGRLSAITMALQYGSESEEDAA
LAAARYEEGESEAESITSFMDVSNPFYQLYDTVRSCRNNQGQLIAEPFYHLPSKKKYPDYYQQIKMPISLQQIRTKLKNQEYETLDHLEC
DLNLMFENAKRYNVPNSAIYKRVLKLQQVMQAKKKELARRDDIEDGDSMISSATSDTGSAKRKSKKNIRKQRMKILFNVVLEAREPGSGR
RLCDLFMVKPSKKDYPDYYKIILEPMDLKIIEHNIRNDKYAGEEGMIEDMKLMFRNARHYNEEGSQVYNDAHILEKLLKEKRKELGPLPD
DDDMASPKLKLSRKSGISPKKSKYMTPMQQKLNEVYEAVKNYTDKRGRRLSAIFLRLPSRSELPDYYLTIKKPMDMEKIRSHMMANKYQD
IDSMVEDFVMMFNNACTYNEPESLIYKDALVLHKVLLETRRDLEGDEDSHVPNVTLLIQELIHNLFVSVMSHQDDEGRCYSDSLAEIPAV
DPNFPNKPPLTFDIIRKNVENNRYRRLDLFQEHMFEVLERARRMNRKGQTNEINALVQLMTQTLKLDSKESCEDVPVANPVSEFKLHRKY
RDTLILHGKVAEEAEEIHFKELPSAIMPGSEKIRRLVEVLRTDVIRGLGVQLLEQVYDLLEEEDEFDREVRLREHMGEKYTTYSVKARQL

--------------------------------------------------------------

>63006_63006_11_PBRM1-NEK4_PBRM1_chr3_52643329_ENST00000409057_NEK4_chr3_52773650_ENST00000383721_length(amino acids)=985AA_BP=855
MGSKRRRATSPSSSVSGDFDDGHHSVSTPGPSRKRRRLSNLPTVDPIAVCHELYNTIRDYKDEQGRLLCELFIRAPKRRNQPDYYEVVSQ
PIDLMKIQQKLKMEEYDDVNLLTADFQLLFNNAKSYYKPDSPEYKAACKLWDLYLRTRNEFVQKGEADDEDDDEDGQDNQGTVTEGSSPA
YLKEILEQLLEAIVVATNPSGRLISELFQKLPSKVQYPDYYAIIKEPIDLKTIAQRIQNGSYKSIHAMAKDIDLLAKNAKTYNEPGSQVF
KDANSIKKIFYMKKAEIEHHEMAKSSLRMRTPSNLAAARLTGPSHSKGSLGEERNPTSKYYRNKRAVQGGRLSAITMALQYGSESEEDAA
LAAARYEEGESEAESITSFMDVSNPFYQLYDTVRSCRNNQGQLIAEPFYHLPSKKKYPDYYQQIKMPISLQQIRTKLKNQEYETLDHLEC
DLNLMFENAKRYNVPNSAIYKRVLKLQQVMQAKKKELARRDDIEDGDSMISSATSDTGSAKRKSKKNIRKQRMKILFNVVLEAREPGSGR
RLCDLFMVKPSKKDYPDYYKIILEPMDLKIIEHNIRNDKYAGEEGMIEDMKLMFRNARHYNEEGSQVYNDAHILEKLLKEKRKELGPLPD
DDDMASPKLKLSRKSGISPKKSKYMTPMQQKLNEVYEAVKNYTDKRGRRLSAIFLRLPSRSELPDYYLTIKKPMDMEKIRSHMMANKYQD
IDSMVEDFVMMFNNACTYNEPESLIYKDALVLHKVLLETRRDLEGDEDSHVPNVTLLIQELIHNLFVSVMSHQDDEGRCYSDSLAEIPAV
DPNFPNKPPLTFDIIRKNVENNRYRRLDLFQEHMFEVLERARRMNRKGQTNEINALVQLMTQTLKLDSKESCEDVPVANPVSEFKLHRKY

--------------------------------------------------------------

>63006_63006_12_PBRM1-NEK4_PBRM1_chr3_52643329_ENST00000409057_NEK4_chr3_52773650_ENST00000535191_length(amino acids)=999AA_BP=855
MGSKRRRATSPSSSVSGDFDDGHHSVSTPGPSRKRRRLSNLPTVDPIAVCHELYNTIRDYKDEQGRLLCELFIRAPKRRNQPDYYEVVSQ
PIDLMKIQQKLKMEEYDDVNLLTADFQLLFNNAKSYYKPDSPEYKAACKLWDLYLRTRNEFVQKGEADDEDDDEDGQDNQGTVTEGSSPA
YLKEILEQLLEAIVVATNPSGRLISELFQKLPSKVQYPDYYAIIKEPIDLKTIAQRIQNGSYKSIHAMAKDIDLLAKNAKTYNEPGSQVF
KDANSIKKIFYMKKAEIEHHEMAKSSLRMRTPSNLAAARLTGPSHSKGSLGEERNPTSKYYRNKRAVQGGRLSAITMALQYGSESEEDAA
LAAARYEEGESEAESITSFMDVSNPFYQLYDTVRSCRNNQGQLIAEPFYHLPSKKKYPDYYQQIKMPISLQQIRTKLKNQEYETLDHLEC
DLNLMFENAKRYNVPNSAIYKRVLKLQQVMQAKKKELARRDDIEDGDSMISSATSDTGSAKRKSKKNIRKQRMKILFNVVLEAREPGSGR
RLCDLFMVKPSKKDYPDYYKIILEPMDLKIIEHNIRNDKYAGEEGMIEDMKLMFRNARHYNEEGSQVYNDAHILEKLLKEKRKELGPLPD
DDDMASPKLKLSRKSGISPKKSKYMTPMQQKLNEVYEAVKNYTDKRGRRLSAIFLRLPSRSELPDYYLTIKKPMDMEKIRSHMMANKYQD
IDSMVEDFVMMFNNACTYNEPESLIYKDALVLHKVLLETRRDLEGDEDSHVPNVTLLIQELIHNLFVSVMSHQDDEGRCYSDSLAEIPAV
DPNFPNKPPLTFDIIRKNVENNRYRRLDLFQEHMFEVLERARRMNRKGQTNEINALVQLMTQTLKLDSKESCEDVPVANPVSEFKLHRKY
RDTLILHGKVAEEAEEIHFKELPSAIMPGSEKIRRLVEVLRTDVIRGLGVQLLEQVYDLLEEEDEFDREVRLREHMGEKYTTYSVKARQL

--------------------------------------------------------------

>63006_63006_13_PBRM1-NEK4_PBRM1_chr3_52643329_ENST00000409114_NEK4_chr3_52773650_ENST00000233027_length(amino acids)=1014AA_BP=870
MGSKRRRATSPSSSVSGDFDDGHHSVSTPGPSRKRRRLSNLPTVDPIAVCHELYNTIRDYKDEQGRLLCELFIRAPKRRNQPDYYEVVSQ
PIDLMKIQQKLKMEEYDDVNLLTADFQLLFNNAKSYYKPDSPEYKAACKLWDLYLRTRNEFVQKGEADDEDDDEDGQDNQGTVTEGSSPA
YLKEILEQLLEAIVVATNPSGRLISELFQKLPSKVQYPDYYAIIKEPIDLKTIAQRIQNGSYKSIHAMAKDIDLLAKNAKTYNEPGSQVF
KDANSIKKIFYMKKAEIEHHEMAKSSLRMRTPSNLAAARLTGPSHSKGSLGEERNPTSKYYRNKRAVQGGRLSAITMALQYGSESEEDAA
LAAARYEEGESEAESITSFMDVSNPFYQLYDTVRSCRNNQGQLIAEPFYHLPSKKKYPDYYQQIKMPISLQQIRTKLKNQEYETLDHLEC
DLNLMFENAKRYNVPNSAIYKRVLKLQQVMQAKKKELARRDDIEDGDSMISSATSDTGSAKRKRNTHDSEMLGLRRLSSKKNIRKQRMKI
LFNVVLEAREPGSGRRLCDLFMVKPSKKDYPDYYKIILEPMDLKIIEHNIRNDKYAGEEGMIEDMKLMFRNARHYNEEGSQVYNDAHILE
KLLKEKRKELGPLPDDDDMASPKLKLSRKSGISPKKSKYMTPMQQKLNEVYEAVKNYTDKRGRRLSAIFLRLPSRSELPDYYLTIKKPMD
MEKIRSHMMANKYQDIDSMVEDFVMMFNNACTYNEPESLIYKDALVLHKVLLETRRDLEGDEDSHVPNVTLLIQELIHNLFVSVMSHQDD
EGRCYSDSLAEIPAVDPNFPNKPPLTFDIIRKNVENNRYRRLDLFQEHMFEVLERARRMNRKGQTNEINALVQLMTQTLKLDSKESCEDV
PVANPVSEFKLHRKYRDTLILHGKVAEEAEEIHFKELPSAIMPGSEKIRRLVEVLRTDVIRGLGVQLLEQVYDLLEEEDEFDREVRLREH

--------------------------------------------------------------

>63006_63006_14_PBRM1-NEK4_PBRM1_chr3_52643329_ENST00000409114_NEK4_chr3_52773650_ENST00000383721_length(amino acids)=1000AA_BP=870
MGSKRRRATSPSSSVSGDFDDGHHSVSTPGPSRKRRRLSNLPTVDPIAVCHELYNTIRDYKDEQGRLLCELFIRAPKRRNQPDYYEVVSQ
PIDLMKIQQKLKMEEYDDVNLLTADFQLLFNNAKSYYKPDSPEYKAACKLWDLYLRTRNEFVQKGEADDEDDDEDGQDNQGTVTEGSSPA
YLKEILEQLLEAIVVATNPSGRLISELFQKLPSKVQYPDYYAIIKEPIDLKTIAQRIQNGSYKSIHAMAKDIDLLAKNAKTYNEPGSQVF
KDANSIKKIFYMKKAEIEHHEMAKSSLRMRTPSNLAAARLTGPSHSKGSLGEERNPTSKYYRNKRAVQGGRLSAITMALQYGSESEEDAA
LAAARYEEGESEAESITSFMDVSNPFYQLYDTVRSCRNNQGQLIAEPFYHLPSKKKYPDYYQQIKMPISLQQIRTKLKNQEYETLDHLEC
DLNLMFENAKRYNVPNSAIYKRVLKLQQVMQAKKKELARRDDIEDGDSMISSATSDTGSAKRKRNTHDSEMLGLRRLSSKKNIRKQRMKI
LFNVVLEAREPGSGRRLCDLFMVKPSKKDYPDYYKIILEPMDLKIIEHNIRNDKYAGEEGMIEDMKLMFRNARHYNEEGSQVYNDAHILE
KLLKEKRKELGPLPDDDDMASPKLKLSRKSGISPKKSKYMTPMQQKLNEVYEAVKNYTDKRGRRLSAIFLRLPSRSELPDYYLTIKKPMD
MEKIRSHMMANKYQDIDSMVEDFVMMFNNACTYNEPESLIYKDALVLHKVLLETRRDLEGDEDSHVPNVTLLIQELIHNLFVSVMSHQDD
EGRCYSDSLAEIPAVDPNFPNKPPLTFDIIRKNVENNRYRRLDLFQEHMFEVLERARRMNRKGQTNEINALVQLMTQTLKLDSKESCEDV
PVANPVSEFKLHRKYRDTLILHGKVAEEAEEIHFKELPSAIMPGSEKIRRLVEVLRTDVIRGLGVQLLEQVYDLLEEEDEFDREVSVSLT

--------------------------------------------------------------

>63006_63006_15_PBRM1-NEK4_PBRM1_chr3_52643329_ENST00000409114_NEK4_chr3_52773650_ENST00000535191_length(amino acids)=1014AA_BP=870
MGSKRRRATSPSSSVSGDFDDGHHSVSTPGPSRKRRRLSNLPTVDPIAVCHELYNTIRDYKDEQGRLLCELFIRAPKRRNQPDYYEVVSQ
PIDLMKIQQKLKMEEYDDVNLLTADFQLLFNNAKSYYKPDSPEYKAACKLWDLYLRTRNEFVQKGEADDEDDDEDGQDNQGTVTEGSSPA
YLKEILEQLLEAIVVATNPSGRLISELFQKLPSKVQYPDYYAIIKEPIDLKTIAQRIQNGSYKSIHAMAKDIDLLAKNAKTYNEPGSQVF
KDANSIKKIFYMKKAEIEHHEMAKSSLRMRTPSNLAAARLTGPSHSKGSLGEERNPTSKYYRNKRAVQGGRLSAITMALQYGSESEEDAA
LAAARYEEGESEAESITSFMDVSNPFYQLYDTVRSCRNNQGQLIAEPFYHLPSKKKYPDYYQQIKMPISLQQIRTKLKNQEYETLDHLEC
DLNLMFENAKRYNVPNSAIYKRVLKLQQVMQAKKKELARRDDIEDGDSMISSATSDTGSAKRKRNTHDSEMLGLRRLSSKKNIRKQRMKI
LFNVVLEAREPGSGRRLCDLFMVKPSKKDYPDYYKIILEPMDLKIIEHNIRNDKYAGEEGMIEDMKLMFRNARHYNEEGSQVYNDAHILE
KLLKEKRKELGPLPDDDDMASPKLKLSRKSGISPKKSKYMTPMQQKLNEVYEAVKNYTDKRGRRLSAIFLRLPSRSELPDYYLTIKKPMD
MEKIRSHMMANKYQDIDSMVEDFVMMFNNACTYNEPESLIYKDALVLHKVLLETRRDLEGDEDSHVPNVTLLIQELIHNLFVSVMSHQDD
EGRCYSDSLAEIPAVDPNFPNKPPLTFDIIRKNVENNRYRRLDLFQEHMFEVLERARRMNRKGQTNEINALVQLMTQTLKLDSKESCEDV
PVANPVSEFKLHRKYRDTLILHGKVAEEAEEIHFKELPSAIMPGSEKIRRLVEVLRTDVIRGLGVQLLEQVYDLLEEEDEFDREVRLREH

--------------------------------------------------------------

>63006_63006_16_PBRM1-NEK4_PBRM1_chr3_52643329_ENST00000409767_NEK4_chr3_52773650_ENST00000233027_length(amino acids)=1014AA_BP=870
MGSKRRRATSPSSSVSGDFDDGHHSVSTPGPSRKRRRLSNLPTVDPIAVCHELYNTIRDYKDEQGRLLCELFIRAPKRRNQPDYYEVVSQ
PIDLMKIQQKLKMEEYDDVNLLTADFQLLFNNAKSYYKPDSPEYKAACKLWDLYLRTRNEFVQKGEADDEDDDEDGQDNQGTVTEGSSPA
YLKEILEQLLEAIVVATNPSGRLISELFQKLPSKVQYPDYYAIIKEPIDLKTIAQRIQNGSYKSIHAMAKDIDLLAKNAKTYNEPGSQVF
KDANSIKKIFYMKKAEIEHHEMAKSSLRMRTPSNLAAARLTGPSHSKGSLGEERNPTSKYYRNKRAVQGGRLSAITMALQYGSESEEDAA
LAAARYEEGESEAESITSFMDVSNPFYQLYDTVRSCRNNQGQLIAEPFYHLPSKKKYPDYYQQIKMPISLQQIRTKLKNQEYETLDHLEC
DLNLMFENAKRYNVPNSAIYKRVLKLQQVMQAKKKELARRDDIEDGDSMISSATSDTGSAKRKRNTHDSEMLGLRRLSSKKNIRKQRMKI
LFNVVLEAREPGSGRRLCDLFMVKPSKKDYPDYYKIILEPMDLKIIEHNIRNDKYAGEEGMIEDMKLMFRNARHYNEEGSQVYNDAHILE
KLLKEKRKELGPLPDDDDMASPKLKLSRKSGISPKKSKYMTPMQQKLNEVYEAVKNYTDKRGRRLSAIFLRLPSRSELPDYYLTIKKPMD
MEKIRSHMMANKYQDIDSMVEDFVMMFNNACTYNEPESLIYKDALVLHKVLLETRRDLEGDEDSHVPNVTLLIQELIHNLFVSVMSHQDD
EGRCYSDSLAEIPAVDPNFPNKPPLTFDIIRKNVENNRYRRLDLFQEHMFEVLERARRMNRKGQTNEINALVQLMTQTLKLDSKESCEDV
PVANPVSEFKLHRKYRDTLILHGKVAEEAEEIHFKELPSAIMPGSEKIRRLVEVLRTDVIRGLGVQLLEQVYDLLEEEDEFDREVRLREH

--------------------------------------------------------------

>63006_63006_17_PBRM1-NEK4_PBRM1_chr3_52643329_ENST00000409767_NEK4_chr3_52773650_ENST00000383721_length(amino acids)=1000AA_BP=870
MGSKRRRATSPSSSVSGDFDDGHHSVSTPGPSRKRRRLSNLPTVDPIAVCHELYNTIRDYKDEQGRLLCELFIRAPKRRNQPDYYEVVSQ
PIDLMKIQQKLKMEEYDDVNLLTADFQLLFNNAKSYYKPDSPEYKAACKLWDLYLRTRNEFVQKGEADDEDDDEDGQDNQGTVTEGSSPA
YLKEILEQLLEAIVVATNPSGRLISELFQKLPSKVQYPDYYAIIKEPIDLKTIAQRIQNGSYKSIHAMAKDIDLLAKNAKTYNEPGSQVF
KDANSIKKIFYMKKAEIEHHEMAKSSLRMRTPSNLAAARLTGPSHSKGSLGEERNPTSKYYRNKRAVQGGRLSAITMALQYGSESEEDAA
LAAARYEEGESEAESITSFMDVSNPFYQLYDTVRSCRNNQGQLIAEPFYHLPSKKKYPDYYQQIKMPISLQQIRTKLKNQEYETLDHLEC
DLNLMFENAKRYNVPNSAIYKRVLKLQQVMQAKKKELARRDDIEDGDSMISSATSDTGSAKRKRNTHDSEMLGLRRLSSKKNIRKQRMKI
LFNVVLEAREPGSGRRLCDLFMVKPSKKDYPDYYKIILEPMDLKIIEHNIRNDKYAGEEGMIEDMKLMFRNARHYNEEGSQVYNDAHILE
KLLKEKRKELGPLPDDDDMASPKLKLSRKSGISPKKSKYMTPMQQKLNEVYEAVKNYTDKRGRRLSAIFLRLPSRSELPDYYLTIKKPMD
MEKIRSHMMANKYQDIDSMVEDFVMMFNNACTYNEPESLIYKDALVLHKVLLETRRDLEGDEDSHVPNVTLLIQELIHNLFVSVMSHQDD
EGRCYSDSLAEIPAVDPNFPNKPPLTFDIIRKNVENNRYRRLDLFQEHMFEVLERARRMNRKGQTNEINALVQLMTQTLKLDSKESCEDV
PVANPVSEFKLHRKYRDTLILHGKVAEEAEEIHFKELPSAIMPGSEKIRRLVEVLRTDVIRGLGVQLLEQVYDLLEEEDEFDREVSVSLT

--------------------------------------------------------------

>63006_63006_18_PBRM1-NEK4_PBRM1_chr3_52643329_ENST00000409767_NEK4_chr3_52773650_ENST00000535191_length(amino acids)=1014AA_BP=870
MGSKRRRATSPSSSVSGDFDDGHHSVSTPGPSRKRRRLSNLPTVDPIAVCHELYNTIRDYKDEQGRLLCELFIRAPKRRNQPDYYEVVSQ
PIDLMKIQQKLKMEEYDDVNLLTADFQLLFNNAKSYYKPDSPEYKAACKLWDLYLRTRNEFVQKGEADDEDDDEDGQDNQGTVTEGSSPA
YLKEILEQLLEAIVVATNPSGRLISELFQKLPSKVQYPDYYAIIKEPIDLKTIAQRIQNGSYKSIHAMAKDIDLLAKNAKTYNEPGSQVF
KDANSIKKIFYMKKAEIEHHEMAKSSLRMRTPSNLAAARLTGPSHSKGSLGEERNPTSKYYRNKRAVQGGRLSAITMALQYGSESEEDAA
LAAARYEEGESEAESITSFMDVSNPFYQLYDTVRSCRNNQGQLIAEPFYHLPSKKKYPDYYQQIKMPISLQQIRTKLKNQEYETLDHLEC
DLNLMFENAKRYNVPNSAIYKRVLKLQQVMQAKKKELARRDDIEDGDSMISSATSDTGSAKRKRNTHDSEMLGLRRLSSKKNIRKQRMKI
LFNVVLEAREPGSGRRLCDLFMVKPSKKDYPDYYKIILEPMDLKIIEHNIRNDKYAGEEGMIEDMKLMFRNARHYNEEGSQVYNDAHILE
KLLKEKRKELGPLPDDDDMASPKLKLSRKSGISPKKSKYMTPMQQKLNEVYEAVKNYTDKRGRRLSAIFLRLPSRSELPDYYLTIKKPMD
MEKIRSHMMANKYQDIDSMVEDFVMMFNNACTYNEPESLIYKDALVLHKVLLETRRDLEGDEDSHVPNVTLLIQELIHNLFVSVMSHQDD
EGRCYSDSLAEIPAVDPNFPNKPPLTFDIIRKNVENNRYRRLDLFQEHMFEVLERARRMNRKGQTNEINALVQLMTQTLKLDSKESCEDV
PVANPVSEFKLHRKYRDTLILHGKVAEEAEEIHFKELPSAIMPGSEKIRRLVEVLRTDVIRGLGVQLLEQVYDLLEEEDEFDREVRLREH

--------------------------------------------------------------

>63006_63006_19_PBRM1-NEK4_PBRM1_chr3_52643329_ENST00000410007_NEK4_chr3_52773650_ENST00000233027_length(amino acids)=999AA_BP=855
MGSKRRRATSPSSSVSGDFDDGHHSVSTPGPSRKRRRLSNLPTVDPIAVCHELYNTIRDYKDEQGRLLCELFIRAPKRRNQPDYYEVVSQ
PIDLMKIQQKLKMEEYDDVNLLTADFQLLFNNAKSYYKPDSPEYKAACKLWDLYLRTRNEFVQKGEADDEDDDEDGQDNQGTVTEGSSPA
YLKEILEQLLEAIVVATNPSGRLISELFQKLPSKVQYPDYYAIIKEPIDLKTIAQRIQNGSYKSIHAMAKDIDLLAKNAKTYNEPGSQVF
KDANSIKKIFYMKKAEIEHHEMAKSSLRMRTPSNLAAARLTGPSHSKGSLGEERNPTSKYYRNKRAVQGGRLSAITMALQYGSESEEDAA
LAAARYEEGESEAESITSFMDVSNPFYQLYDTVRSCRNNQGQLIAEPFYHLPSKKKYPDYYQQIKMPISLQQIRTKLKNQEYETLDHLEC
DLNLMFENAKRYNVPNSAIYKRVLKLQQVMQAKKKELARRDDIEDGDSMISSATSDTGSAKRKSKKNIRKQRMKILFNVVLEAREPGSGR
RLCDLFMVKPSKKDYPDYYKIILEPMDLKIIEHNIRNDKYAGEEGMIEDMKLMFRNARHYNEEGSQVYNDAHILEKLLKEKRKELGPLPD
DDDMASPKLKLSRKSGISPKKSKYMTPMQQKLNEVYEAVKNYTDKRGRRLSAIFLRLPSRSELPDYYLTIKKPMDMEKIRSHMMANKYQD
IDSMVEDFVMMFNNACTYNEPESLIYKDALVLHKVLLETRRDLEGDEDSHVPNVTLLIQELIHNLFVSVMSHQDDEGRCYSDSLAEIPAV
DPNFPNKPPLTFDIIRKNVENNRYRRLDLFQEHMFEVLERARRMNRKGQTNEINALVQLMTQTLKLDSKESCEDVPVANPVSEFKLHRKY
RDTLILHGKVAEEAEEIHFKELPSAIMPGSEKIRRLVEVLRTDVIRGLGVQLLEQVYDLLEEEDEFDREVRLREHMGEKYTTYSVKARQL

--------------------------------------------------------------

>63006_63006_20_PBRM1-NEK4_PBRM1_chr3_52643329_ENST00000410007_NEK4_chr3_52773650_ENST00000383721_length(amino acids)=985AA_BP=855
MGSKRRRATSPSSSVSGDFDDGHHSVSTPGPSRKRRRLSNLPTVDPIAVCHELYNTIRDYKDEQGRLLCELFIRAPKRRNQPDYYEVVSQ
PIDLMKIQQKLKMEEYDDVNLLTADFQLLFNNAKSYYKPDSPEYKAACKLWDLYLRTRNEFVQKGEADDEDDDEDGQDNQGTVTEGSSPA
YLKEILEQLLEAIVVATNPSGRLISELFQKLPSKVQYPDYYAIIKEPIDLKTIAQRIQNGSYKSIHAMAKDIDLLAKNAKTYNEPGSQVF
KDANSIKKIFYMKKAEIEHHEMAKSSLRMRTPSNLAAARLTGPSHSKGSLGEERNPTSKYYRNKRAVQGGRLSAITMALQYGSESEEDAA
LAAARYEEGESEAESITSFMDVSNPFYQLYDTVRSCRNNQGQLIAEPFYHLPSKKKYPDYYQQIKMPISLQQIRTKLKNQEYETLDHLEC
DLNLMFENAKRYNVPNSAIYKRVLKLQQVMQAKKKELARRDDIEDGDSMISSATSDTGSAKRKSKKNIRKQRMKILFNVVLEAREPGSGR
RLCDLFMVKPSKKDYPDYYKIILEPMDLKIIEHNIRNDKYAGEEGMIEDMKLMFRNARHYNEEGSQVYNDAHILEKLLKEKRKELGPLPD
DDDMASPKLKLSRKSGISPKKSKYMTPMQQKLNEVYEAVKNYTDKRGRRLSAIFLRLPSRSELPDYYLTIKKPMDMEKIRSHMMANKYQD
IDSMVEDFVMMFNNACTYNEPESLIYKDALVLHKVLLETRRDLEGDEDSHVPNVTLLIQELIHNLFVSVMSHQDDEGRCYSDSLAEIPAV
DPNFPNKPPLTFDIIRKNVENNRYRRLDLFQEHMFEVLERARRMNRKGQTNEINALVQLMTQTLKLDSKESCEDVPVANPVSEFKLHRKY

--------------------------------------------------------------

>63006_63006_21_PBRM1-NEK4_PBRM1_chr3_52643329_ENST00000410007_NEK4_chr3_52773650_ENST00000535191_length(amino acids)=999AA_BP=855
MGSKRRRATSPSSSVSGDFDDGHHSVSTPGPSRKRRRLSNLPTVDPIAVCHELYNTIRDYKDEQGRLLCELFIRAPKRRNQPDYYEVVSQ
PIDLMKIQQKLKMEEYDDVNLLTADFQLLFNNAKSYYKPDSPEYKAACKLWDLYLRTRNEFVQKGEADDEDDDEDGQDNQGTVTEGSSPA
YLKEILEQLLEAIVVATNPSGRLISELFQKLPSKVQYPDYYAIIKEPIDLKTIAQRIQNGSYKSIHAMAKDIDLLAKNAKTYNEPGSQVF
KDANSIKKIFYMKKAEIEHHEMAKSSLRMRTPSNLAAARLTGPSHSKGSLGEERNPTSKYYRNKRAVQGGRLSAITMALQYGSESEEDAA
LAAARYEEGESEAESITSFMDVSNPFYQLYDTVRSCRNNQGQLIAEPFYHLPSKKKYPDYYQQIKMPISLQQIRTKLKNQEYETLDHLEC
DLNLMFENAKRYNVPNSAIYKRVLKLQQVMQAKKKELARRDDIEDGDSMISSATSDTGSAKRKSKKNIRKQRMKILFNVVLEAREPGSGR
RLCDLFMVKPSKKDYPDYYKIILEPMDLKIIEHNIRNDKYAGEEGMIEDMKLMFRNARHYNEEGSQVYNDAHILEKLLKEKRKELGPLPD
DDDMASPKLKLSRKSGISPKKSKYMTPMQQKLNEVYEAVKNYTDKRGRRLSAIFLRLPSRSELPDYYLTIKKPMDMEKIRSHMMANKYQD
IDSMVEDFVMMFNNACTYNEPESLIYKDALVLHKVLLETRRDLEGDEDSHVPNVTLLIQELIHNLFVSVMSHQDDEGRCYSDSLAEIPAV
DPNFPNKPPLTFDIIRKNVENNRYRRLDLFQEHMFEVLERARRMNRKGQTNEINALVQLMTQTLKLDSKESCEDVPVANPVSEFKLHRKY
RDTLILHGKVAEEAEEIHFKELPSAIMPGSEKIRRLVEVLRTDVIRGLGVQLLEQVYDLLEEEDEFDREVRLREHMGEKYTTYSVKARQL

--------------------------------------------------------------

Top

Fusion Protein Functional Features

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr3:52637537/chr3:52773650)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	NEK4 P51957
FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.	FUNCTION: Protein kinase that seems to act exclusively upon threonine residues (By similarity). Required for normal entry into proliferative arrest after a limited number of cell divisions, also called replicative senescence. Required for normal cell cycle arrest in response to double-stranded DNA damage. {ECO:0000250\|UniProtKB:Q9Z1J2, ECO:0000269\|PubMed:22851694}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
* Minus value of BPloci means that the break pointn is located before the CDS.

- Retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

PBRM1

chr3:52643329

chr3:52773650

ENST00000296302

630_633

855.6666666666666

1690.0

Compositional bias

Note=Poly-Asp

Hgene

PBRM1

chr3:52643329

chr3:52773650

ENST00000337303

630_633

855.6666666666666

1583.0

Compositional bias

Note=Poly-Asp

Hgene

PBRM1

chr3:52643329

chr3:52773650

ENST00000356770

630_633

823.6666666666666

1603.0

Compositional bias

Note=Poly-Asp

Hgene

PBRM1

chr3:52643329

chr3:52773650

ENST00000394830

630_633

855.6666666666666

1583.0

Compositional bias

Note=Poly-Asp

Hgene

PBRM1

chr3:52643329

chr3:52773650

ENST00000409057

630_633

855.6666666666666

1635.0

Compositional bias

Note=Poly-Asp

Hgene

PBRM1

chr3:52643329

chr3:52773650

ENST00000409114

630_633

870.6666666666666

1653.0

Compositional bias

Note=Poly-Asp

Hgene

PBRM1

chr3:52643329

chr3:52773650

ENST00000409767

630_633

870.6666666666666

1598.0

Compositional bias

Note=Poly-Asp

Hgene

PBRM1

chr3:52643329

chr3:52773650

ENST00000410007

630_633

855.6666666666666

1610.0

Compositional bias

Note=Poly-Asp

Hgene

PBRM1

chr3:52643329

chr3:52773650

ENST00000296302

200_270

855.6666666666666

1690.0

Domain

Bromo 2

Hgene

PBRM1

chr3:52643329

chr3:52773650

ENST00000296302

400_470

855.6666666666666

1690.0

Domain

Bromo 3

Hgene

PBRM1

chr3:52643329

chr3:52773650

ENST00000296302

538_608

855.6666666666666

1690.0

Domain

Bromo 4

Hgene

PBRM1

chr3:52643329

chr3:52773650

ENST00000296302

64_134

855.6666666666666

1690.0

Domain

Bromo 1

Hgene

PBRM1

chr3:52643329

chr3:52773650

ENST00000296302

676_746

855.6666666666666

1690.0

Domain

Bromo 5

Hgene

PBRM1

chr3:52643329

chr3:52773650

ENST00000337303

200_270

855.6666666666666

1583.0

Domain

Bromo 2

Hgene

PBRM1

chr3:52643329

chr3:52773650

ENST00000337303

400_470

855.6666666666666

1583.0

Domain

Bromo 3

Hgene

PBRM1

chr3:52643329

chr3:52773650

ENST00000337303

538_608

855.6666666666666

1583.0

Domain

Bromo 4

Hgene

PBRM1

chr3:52643329

chr3:52773650

ENST00000337303

64_134

855.6666666666666

1583.0

Domain

Bromo 1

Hgene

PBRM1

chr3:52643329

chr3:52773650

ENST00000337303

676_746

855.6666666666666

1583.0

Domain

Bromo 5

Hgene

PBRM1

chr3:52643329

chr3:52773650

ENST00000356770

200_270

823.6666666666666

1603.0

Domain

Bromo 2

Hgene

PBRM1

chr3:52643329

chr3:52773650

ENST00000356770

400_470

823.6666666666666

1603.0

Domain

Bromo 3

Hgene

PBRM1

chr3:52643329

chr3:52773650

ENST00000356770

538_608

823.6666666666666

1603.0

Domain

Bromo 4

Hgene

PBRM1

chr3:52643329

chr3:52773650

ENST00000356770

64_134

823.6666666666666

1603.0

Domain

Bromo 1

Hgene

PBRM1

chr3:52643329

chr3:52773650

ENST00000356770

676_746

823.6666666666666

1603.0

Domain

Bromo 5

Hgene

PBRM1

chr3:52643329

chr3:52773650

ENST00000394830

200_270

855.6666666666666

1583.0

Domain

Bromo 2

Hgene

PBRM1

chr3:52643329

chr3:52773650

ENST00000394830

400_470

855.6666666666666

1583.0

Domain

Bromo 3

Hgene

PBRM1

chr3:52643329

chr3:52773650

ENST00000394830

538_608

855.6666666666666

1583.0

Domain

Bromo 4

Hgene

PBRM1

chr3:52643329

chr3:52773650

ENST00000394830

64_134

855.6666666666666

1583.0

Domain

Bromo 1

Hgene

PBRM1

chr3:52643329

chr3:52773650

ENST00000394830

676_746

855.6666666666666

1583.0

Domain

Bromo 5

Hgene

PBRM1

chr3:52643329

chr3:52773650

ENST00000409057

200_270

855.6666666666666

1635.0

Domain

Bromo 2

Hgene

PBRM1

chr3:52643329

chr3:52773650

ENST00000409057

400_470

855.6666666666666

1635.0

Domain

Bromo 3

Hgene

PBRM1

chr3:52643329

chr3:52773650

ENST00000409057

538_608

855.6666666666666

1635.0

Domain

Bromo 4

Hgene

PBRM1

chr3:52643329

chr3:52773650

ENST00000409057

64_134

855.6666666666666

1635.0

Domain

Bromo 1

Hgene

PBRM1

chr3:52643329

chr3:52773650

ENST00000409057

676_746

855.6666666666666

1635.0

Domain

Bromo 5

Hgene

PBRM1

chr3:52643329

chr3:52773650

ENST00000409114

200_270

870.6666666666666

1653.0

Domain

Bromo 2

Hgene

PBRM1

chr3:52643329

chr3:52773650

ENST00000409114

400_470

870.6666666666666

1653.0

Domain

Bromo 3

Hgene

PBRM1

chr3:52643329

chr3:52773650

ENST00000409114

538_608

870.6666666666666

1653.0

Domain

Bromo 4

Hgene

PBRM1

chr3:52643329

chr3:52773650

ENST00000409114

64_134

870.6666666666666

1653.0

Domain

Bromo 1

Hgene

PBRM1

chr3:52643329

chr3:52773650

ENST00000409114

676_746

870.6666666666666

1653.0

Domain

Bromo 5

Hgene

PBRM1

chr3:52643329

chr3:52773650

ENST00000409114

792_862

870.6666666666666

1653.0

Domain

Bromo 6

Hgene

PBRM1

chr3:52643329

chr3:52773650

ENST00000409767

200_270

870.6666666666666

1598.0

Domain

Bromo 2

Hgene

PBRM1

chr3:52643329

chr3:52773650

ENST00000409767

400_470

870.6666666666666

1598.0

Domain

Bromo 3

Hgene

PBRM1

chr3:52643329

chr3:52773650

ENST00000409767

538_608

870.6666666666666

1598.0

Domain

Bromo 4

Hgene

PBRM1

chr3:52643329

chr3:52773650

ENST00000409767

64_134

870.6666666666666

1598.0

Domain

Bromo 1

Hgene

PBRM1

chr3:52643329

chr3:52773650

ENST00000409767

676_746

870.6666666666666

1598.0

Domain

Bromo 5

Hgene

PBRM1

chr3:52643329

chr3:52773650

ENST00000409767

792_862

870.6666666666666

1598.0

Domain

Bromo 6

Hgene

PBRM1

chr3:52643329

chr3:52773650

ENST00000410007

200_270

855.6666666666666

1610.0

Domain

Bromo 2

Hgene

PBRM1

chr3:52643329

chr3:52773650

ENST00000410007

400_470

855.6666666666666

1610.0

Domain

Bromo 3

Hgene

PBRM1

chr3:52643329

chr3:52773650

ENST00000410007

538_608

855.6666666666666

1610.0

Domain

Bromo 4

Hgene

PBRM1

chr3:52643329

chr3:52773650

ENST00000410007

64_134

855.6666666666666

1610.0

Domain

Bromo 1

Hgene

PBRM1

chr3:52643329

chr3:52773650

ENST00000410007

676_746

855.6666666666666

1610.0

Domain

Bromo 5

- Not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

PBRM1

chr3:52643329

chr3:52773650

ENST00000296302

1468_1599

855.6666666666666

1690.0

Compositional bias

Note=Pro-rich

Hgene

PBRM1

chr3:52643329

chr3:52773650

ENST00000337303

1468_1599

855.6666666666666

1583.0

Compositional bias

Note=Pro-rich

Hgene

PBRM1

chr3:52643329

chr3:52773650

ENST00000356770

1468_1599

823.6666666666666

1603.0

Compositional bias

Note=Pro-rich

Hgene

PBRM1

chr3:52643329

chr3:52773650

ENST00000394830

1468_1599

855.6666666666666

1583.0

Compositional bias

Note=Pro-rich

Hgene

PBRM1

chr3:52643329

chr3:52773650

ENST00000409057

1468_1599

855.6666666666666

1635.0

Compositional bias

Note=Pro-rich

Hgene

PBRM1

chr3:52643329

chr3:52773650

ENST00000409114

1468_1599

870.6666666666666

1653.0

Compositional bias

Note=Pro-rich

Hgene

PBRM1

chr3:52643329

chr3:52773650

ENST00000409767

1468_1599

870.6666666666666

1598.0

Compositional bias

Note=Pro-rich

Hgene

PBRM1

chr3:52643329

chr3:52773650

ENST00000410007

1468_1599

855.6666666666666

1610.0

Compositional bias

Note=Pro-rich

Hgene

PBRM1

chr3:52643329

chr3:52773650

ENST00000296302

1379_1447

855.6666666666666

1690.0

DNA binding

HMG box

Hgene

PBRM1

chr3:52643329

chr3:52773650

ENST00000337303

1379_1447

855.6666666666666

1583.0

DNA binding

HMG box

Hgene

PBRM1

chr3:52643329

chr3:52773650

ENST00000356770

1379_1447

823.6666666666666

1603.0

DNA binding

HMG box

Hgene

PBRM1

chr3:52643329

chr3:52773650

ENST00000394830

1379_1447

855.6666666666666

1583.0

DNA binding

HMG box

Hgene

PBRM1

chr3:52643329

chr3:52773650

ENST00000409057

1379_1447

855.6666666666666

1635.0

DNA binding

HMG box

Hgene

PBRM1

chr3:52643329

chr3:52773650

ENST00000409114

1379_1447

870.6666666666666

1653.0

DNA binding

HMG box

Hgene

PBRM1

chr3:52643329

chr3:52773650

ENST00000409767

1379_1447

870.6666666666666

1598.0

DNA binding

HMG box

Hgene

PBRM1

chr3:52643329

chr3:52773650

ENST00000410007

1379_1447

855.6666666666666

1610.0

DNA binding

HMG box

Hgene

PBRM1

chr3:52643329

chr3:52773650

ENST00000296302

1156_1272

855.6666666666666

1690.0

Domain

BAH 2

Hgene

PBRM1

chr3:52643329

chr3:52773650

ENST00000296302

792_862

855.6666666666666

1690.0

Domain

Bromo 6

Hgene

PBRM1

chr3:52643329

chr3:52773650

ENST00000296302

956_1074

855.6666666666666

1690.0

Domain

BAH 1

Hgene

PBRM1

chr3:52643329

chr3:52773650

ENST00000337303

1156_1272

855.6666666666666

1583.0

Domain

BAH 2

Hgene

PBRM1

chr3:52643329

chr3:52773650

ENST00000337303

792_862

855.6666666666666

1583.0

Domain

Bromo 6

Hgene

PBRM1

chr3:52643329

chr3:52773650

ENST00000337303

956_1074

855.6666666666666

1583.0

Domain

BAH 1

Hgene

PBRM1

chr3:52643329

chr3:52773650

ENST00000356770

1156_1272

823.6666666666666

1603.0

Domain

BAH 2

Hgene

PBRM1

chr3:52643329

chr3:52773650

ENST00000356770

792_862

823.6666666666666

1603.0

Domain

Bromo 6

Hgene

PBRM1

chr3:52643329

chr3:52773650

ENST00000356770

956_1074

823.6666666666666

1603.0

Domain

BAH 1

Hgene

PBRM1

chr3:52643329

chr3:52773650

ENST00000394830

1156_1272

855.6666666666666

1583.0

Domain

BAH 2

Hgene

PBRM1

chr3:52643329

chr3:52773650

ENST00000394830

792_862

855.6666666666666

1583.0

Domain

Bromo 6

Hgene

PBRM1

chr3:52643329

chr3:52773650

ENST00000394830

956_1074

855.6666666666666

1583.0

Domain

BAH 1

Hgene

PBRM1

chr3:52643329

chr3:52773650

ENST00000409057

1156_1272

855.6666666666666

1635.0

Domain

BAH 2

Hgene

PBRM1

chr3:52643329

chr3:52773650

ENST00000409057

792_862

855.6666666666666

1635.0

Domain

Bromo 6

Hgene

PBRM1

chr3:52643329

chr3:52773650

ENST00000409057

956_1074

855.6666666666666

1635.0

Domain

BAH 1

Hgene

PBRM1

chr3:52643329

chr3:52773650

ENST00000409114

1156_1272

870.6666666666666

1653.0

Domain

BAH 2

Hgene

PBRM1

chr3:52643329

chr3:52773650

ENST00000409114

956_1074

870.6666666666666

1653.0

Domain

BAH 1

Hgene

PBRM1

chr3:52643329

chr3:52773650

ENST00000409767

1156_1272

870.6666666666666

1598.0

Domain

BAH 2

Hgene

PBRM1

chr3:52643329

chr3:52773650

ENST00000409767

956_1074

870.6666666666666

1598.0

Domain

BAH 1

Hgene

PBRM1

chr3:52643329

chr3:52773650

ENST00000410007

1156_1272

855.6666666666666

1610.0

Domain

BAH 2

Hgene

PBRM1

chr3:52643329

chr3:52773650

ENST00000410007

792_862

855.6666666666666

1610.0

Domain

Bromo 6

Hgene

PBRM1

chr3:52643329

chr3:52773650

ENST00000410007

956_1074

855.6666666666666

1610.0

Domain

BAH 1

Tgene

NEK4

chr3:52643329

chr3:52773650

ENST00000233027

6_261

697.6666666666666

842.0

Domain

Protein kinase

Tgene

NEK4

chr3:52643329

chr3:52773650

ENST00000383721

6_261

651.6666666666666

782.0

Domain

Protein kinase

Tgene

NEK4

chr3:52643329

chr3:52773650

ENST00000535191

6_261

608.6666666666666

753.0

Domain

Protein kinase

Tgene

NEK4

chr3:52643329

chr3:52773650

ENST00000233027

12_20

697.6666666666666

842.0

Nucleotide binding

ATP

Tgene

NEK4

chr3:52643329

chr3:52773650

ENST00000383721

12_20

651.6666666666666

782.0

Nucleotide binding

ATP

Tgene

NEK4

chr3:52643329

chr3:52773650

ENST00000535191

12_20

608.6666666666666

753.0

Nucleotide binding

ATP

Top

Fusion Protein-Protein Interaction

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)

Gene

PPI interactors

Protein-protein interactors based on sequence similarity (STRING)

Gene	STRING network
PBRM1
NEK4

- Retained interactions in fusion protein (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost interactions due to fusion (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs to PBRM1-NEK4

Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Drug

Source

PMID

Top

Related Diseases to PBRM1-NEK4

Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Disease

Source

PMID

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source