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Center for Computational Systems Medicine level1
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:PBRM1-TMEM110-MUSTN1

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: PBRM1-TMEM110-MUSTN1
FusionPDB ID: 63012
FusionGDB2.0 ID: 63012
HgeneTgene
Gene symbol

PBRM1

TMEM110-MUSTN1

Gene ID

55193

100526772

Gene namepolybromo 1STIMATE-MUSTN1 readthrough
SynonymsBAF180|PB1TMEM110-MUSTN1
Cytomap

3p21.1

3p21.1

Type of geneprotein-codingprotein-coding
Descriptionprotein polybromo-1BRG1-associated factor 180polybromo-1DTMEM110-MUSTN1 fusion proteinTMEM110-MUSTN1 read-through transcriptTMEM110-MUSTN1 readthrough
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST idsENST00000394830, ENST00000296302, 
ENST00000337303, ENST00000356770, 
ENST00000409057, ENST00000409114, 
ENST00000409767, ENST00000410007, 
ENST00000504329, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score15 X 15 X 10=22501 X 1 X 1=1
# samples 191
** MAII scorelog2(19/2250*10)=-3.56585367777345
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(1/1*10)=3.32192809488736
Context (manual curation of fusion genes in FusionPDB)

PubMed: PBRM1 [Title/Abstract] AND TMEM110-MUSTN1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)PBRM1(52584437)-TMEM110-MUSTN1(52889460), # samples:1
Anticipated loss of major functional domain due to fusion event.PBRM1-TMEM110-MUSTN1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
PBRM1-TMEM110-MUSTN1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
PBRM1-TMEM110-MUSTN1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
PBRM1-TMEM110-MUSTN1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
PBRM1-TMEM110-MUSTN1 seems lost the major protein functional domain in Hgene partner, which is a CGC due to the frame-shifted ORF.
PBRM1-TMEM110-MUSTN1 seems lost the major protein functional domain in Hgene partner, which is a epigenetic factor due to the frame-shifted ORF.
PBRM1-TMEM110-MUSTN1 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
PBRM1-TMEM110-MUSTN1 seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
PBRM1-TMEM110-MUSTN1 seems lost the major protein functional domain in Hgene partner, which is a tumor suppressor due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across PBRM1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across TMEM110-MUSTN1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LUADTCGA-55-8085-01APBRM1chr3

52584437

-TMEM110-MUSTN1chr3

52889460

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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000356770PBRM1chr352584437-ENST00000504329TMEM110-MUSTN1chr352889460-57724639355971864
ENST00000296302PBRM1chr352584437-ENST00000504329TMEM110-MUSTN1chr352889460-60324899258571951
ENST00000337303PBRM1chr352584437-ENST00000504329TMEM110-MUSTN1chr352889460-57124579355371844
ENST00000410007PBRM1chr352584437-ENST00000504329TMEM110-MUSTN1chr352889460-57934660356181871
ENST00000409057PBRM1chr352584437-ENST00000504329TMEM110-MUSTN1chr352889460-58684735356931896
ENST00000409114PBRM1chr352584437-ENST00000504329TMEM110-MUSTN1chr352889460-59224789357471914
ENST00000409767PBRM1chr352584437-ENST00000504329TMEM110-MUSTN1chr352889460-57574624355821859

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000356770ENST00000504329PBRM1chr352584437-TMEM110-MUSTN1chr352889460-0.0010516680.9989484
ENST00000296302ENST00000504329PBRM1chr352584437-TMEM110-MUSTN1chr352889460-0.0011804820.99881953
ENST00000337303ENST00000504329PBRM1chr352584437-TMEM110-MUSTN1chr352889460-0.0005246350.9994754
ENST00000410007ENST00000504329PBRM1chr352584437-TMEM110-MUSTN1chr352889460-0.0009876230.99901235
ENST00000409057ENST00000504329PBRM1chr352584437-TMEM110-MUSTN1chr352889460-0.0010976510.9989023
ENST00000409114ENST00000504329PBRM1chr352584437-TMEM110-MUSTN1chr352889460-0.0004867130.99951327
ENST00000409767ENST00000504329PBRM1chr352584437-TMEM110-MUSTN1chr352889460-0.0005545430.9994455

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>63012_63012_1_PBRM1-TMEM110-MUSTN1_PBRM1_chr3_52584437_ENST00000296302_TMEM110-MUSTN1_chr3_52889460_ENST00000504329_length(amino acids)=1951AA_BP=1630
MGSKRRRATSPSSSVSGDFDDGHHSVSTPGPSRKRRRLSNLPTVDPIAVCHELYNTIRDYKDEQGRLLCELFIRAPKRRNQPDYYEVVSQ
PIDLMKIQQKLKMEEYDDVNLLTADFQLLFNNAKSYYKPDSPEYKAACKLWDLYLRTRNEFVQKGEADDEDDDEDGQDNQGTVTEGSSPA
YLKEILEQLLEAIVVATNPSGRLISELFQKLPSKVQYPDYYAIIKEPIDLKTIAQRIQNGSYKSIHAMAKDIDLLAKNAKTYNEPGSQVF
KDANSIKKIFYMKKAEIEHHEMAKSSLRMRTPSNLAAARLTGPSHSKGSLGEERNPTSKYYRNKRAVQGGRLSAITMALQYGSESEEDAA
LAAARYEEGESEAESITSFMDVSNPFYQLYDTVRSCRNNQGQLIAEPFYHLPSKKKYPDYYQQIKMPISLQQIRTKLKNQEYETLDHLEC
DLNLMFENAKRYNVPNSAIYKRVLKLQQVMQAKKKELARRDDIEDGDSMISSATSDTGSAKRKSKKNIRKQRMKILFNVVLEAREPGSGR
RLCDLFMVKPSKKDYPDYYKIILEPMDLKIIEHNIRNDKYAGEEGMIEDMKLMFRNARHYNEEGSQVYNDAHILEKLLKEKRKELGPLPD
DDDMASPKLKLSRKSGISPKKSKYMTPMQQKLNEVYEAVKNYTDKRGRRLSAIFLRLPSRSELPDYYLTIKKPMDMEKIRSHMMANKYQD
IDSMVEDFVMMFNNACTYNEPESLIYKDALVLHKVLLETRRDLEGDEDSHVPNVTLLIQELIHNLFVSVMSHQDDEGRCYSDSLAEIPAV
DPNFPNKPPLTFDIIRKNVENNRYRRLDLFQEHMFEVLERARRMNRTDSEIYEDAVELQQFFIKIRDELCKNGEILLSPALSYTTKHLHN
DVEKERKEKLPKEIEEDKLKREEEKREAEKSEDSSGAAGLSGLHRTYSQDCSFKNSMYHVGDYVYVEPAEANLQPHIVCIERLWEDSAGE
KWLYGCWFYRPNETFHLATRKFLEKEVFKSDYYNKVPVSKILGKCVVMFVKEYFKLCPENFRDEDVFVCESRYSAKTKSFKKIKLWTMPI
SSVRFVPRDVPLPVVRVASVFANADKGDDEKNTDNSEDSRAEDNFNLEKEKEDVPVEMSNGEPGCHYFEQLHYNDMWLKVGDCVFIKSHG
LVRPRVGRIEKVWVRDGAAYFYGPIFIHPEETEHEPTKMFYKKEVFLSNLEETCPMTCILGKCAVLSFKDFLSCRPTEIPENDILLCESR
YNESDKQMKKFKGLKRFSLSAKVVDDEIYYFRKPIVPQKEPSPLLEKKIQLLEAKFAELEGGDDDIEEMGEEDSEVIEPPSLPQLQTPLA
SELDLMPYTPPQSTPKSAKGSAKKEGSKRKINMSGYILFSSEMRAVIKAQHPDYSFGELSRLVGTEWRNLETAKKAEYEERAAKVAEQQE
RERAAQQQQPSASPRAGTPVGALMGVVPPPTPMGMLNQQLTPVAGMMGGYPPGLPPLQGPVDGLVSMGSMQPLHPGGPPPHHLPPGVPGL
PGIPPPGVMNQGVAPMVGTPAPGGSPYGQQVGVLGPPGQQAPPPYPGPHPAGPPVIQQPTTPMFVAPPPKTQRLLHSEAYLKYIEGLSAE
SNSISKWDQTLAVKRFREPKHERRPWRIWFLDTSKQAIGMLFIHFANVYLADLTEEDPCSLYLINFLLDATVGMLLIYVGVRAVSVLVEW
QQWESLRFGEYGDPLQCGAWVGQCALYIVIMIFEKSVVFIVLLILQWKKVALLNPIENPDLKLAIVMLIVPFFVNALMFWVVDNFLMRKG
KTKAKLEERGANQDSRNGSKVRYRRAASHEESESEILISADDEMEESDVEEDLRRLTPLKPVKKKKHRFGLPAGAQEAPIKKKRPPVKDE

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>63012_63012_2_PBRM1-TMEM110-MUSTN1_PBRM1_chr3_52584437_ENST00000337303_TMEM110-MUSTN1_chr3_52889460_ENST00000504329_length(amino acids)=1844AA_BP=1523
MGSKRRRATSPSSSVSGDFDDGHHSVSTPGPSRKRRRLSNLPTVDPIAVCHELYNTIRDYKDEQGRLLCELFIRAPKRRNQPDYYEVVSQ
PIDLMKIQQKLKMEEYDDVNLLTADFQLLFNNAKSYYKPDSPEYKAACKLWDLYLRTRNEFVQKGEADDEDDDEDGQDNQGTVTEGSSPA
YLKEILEQLLEAIVVATNPSGRLISELFQKLPSKVQYPDYYAIIKEPIDLKTIAQRIQNGSYKSIHAMAKDIDLLAKNAKTYNEPGSQVF
KDANSIKKIFYMKKAEIEHHEMAKSSLRMRTPSNLAAARLTGPSHSKGSLGEERNPTSKYYRNKRAVQGGRLSAITMALQYGSESEEDAA
LAAARYEEGESEAESITSFMDVSNPFYQLYDTVRSCRNNQGQLIAEPFYHLPSKKKYPDYYQQIKMPISLQQIRTKLKNQEYETLDHLEC
DLNLMFENAKRYNVPNSAIYKRVLKLQQVMQAKKKELARRDDIEDGDSMISSATSDTGSAKRKSKKNIRKQRMKILFNVVLEAREPGSGR
RLCDLFMVKPSKKDYPDYYKIILEPMDLKIIEHNIRNDKYAGEEGMIEDMKLMFRNARHYNEEGSQVYNDAHILEKLLKEKRKELGPLPD
DDDMASPKLKLSRKSGISPKKSKYMTPMQQKLNEVYEAVKNYTDKRGRRLSAIFLRLPSRSELPDYYLTIKKPMDMEKIRSHMMANKYQD
IDSMVEDFVMMFNNACTYNEPESLIYKDALVLHKVLLETRRDLEGDEDSHVPNVTLLIQELIHNLFVSVMSHQDDEGRCYSDSLAEIPAV
DPNFPNKPPLTFDIIRKNVENNRYRRLDLFQEHMFEVLERARRMNRTDSEIYEDAVELQQFFIKIRDELCKNGEILLSPALSYTTKHLHN
DVEKERKEKLPKEIEEDKLKREEEKREAEKSEDSSGAAGLSGLHRTYSQDCSFKNSMYHVGDYVYVEPAEANLQPHIVCIERLWEDSAGE
KWLYGCWFYRPNETFHLATRKFLEKEVFKSDYYNKVPVSKILGKCVVMFVKEYFKLCPENFRDEDVFVCESRYSAKTKSFKKIKLWTMPI
SSVRFVPRDVPLPVVRVASVFANADKGDDEKNTDNSEDSRAEDNFNLEKEKEDVPVEMSNGEPGCHYFEQLHYNDMWLKVGDCVFIKSHG
LVRPRVGRIEKVWVRDGAAYFYGPIFIHPEETEHEPTKMFYKKEVFLSNLEETCPMTCILGKCAVLSFKDFLSCRPTEIPENDILLCESR
YNESDKQMKKFKGLKRFSLSAKVVDDEIYYFRKPIVPQKEPSPLLEKKIQLLEAKFAELEGGDDDIEEMGEEDSEVIEPPSLPQLQTPLA
SELDLMPYTPPQSTPKSAKGSAKKEGSKRKINMSGYILFSSEMRAVIKAQHPDYSFGELSRLVGTEWRNLETAKKAEYEGVMNQGVAPMV
GTPAPGGSPYGQQVGVLGPPGQQAPPPYPGPHPAGPPVIQQPTTPMFVAPPPKTQRLLHSEAYLKYIEGLSAESNSISKWDQTLAVKRFR
EPKHERRPWRIWFLDTSKQAIGMLFIHFANVYLADLTEEDPCSLYLINFLLDATVGMLLIYVGVRAVSVLVEWQQWESLRFGEYGDPLQC
GAWVGQCALYIVIMIFEKSVVFIVLLILQWKKVALLNPIENPDLKLAIVMLIVPFFVNALMFWVVDNFLMRKGKTKAKLEERGANQDSRN
GSKVRYRRAASHEESESEILISADDEMEESDVEEDLRRLTPLKPVKKKKHRFGLPAGAQEAPIKKKRPPVKDEDLKGARGNLTKNQEIKS

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>63012_63012_3_PBRM1-TMEM110-MUSTN1_PBRM1_chr3_52584437_ENST00000356770_TMEM110-MUSTN1_chr3_52889460_ENST00000504329_length(amino acids)=1864AA_BP=1543
MGSKRRRATSPSSSVSGDFDDGHHSVSTPGPSRKRRRLSNLPTVDPIAVCHELYNTIRDYKDEQGRLLCELFIRAPKRRNQPDYYEVVSQ
PIDLMKIQQKLKMEEYDDVNLLTADFQLLFNNAKSYYKPDSPEYKAACKLWDLYLRTRNEFVQKGEADDEDDDEDGQDNQGTVTEGSSPA
YLKEILEQLLEAIVVATNPSGRLISELFQKLPSKVQYPDYYAIIKEPIDLKTIAQRIQNGSYKSIHAMAKDIDLLAKNAKTYNEPGSQVF
KDANSIKKIFYMKKAEIEHHEMAKSSLRMSNKRAVQGGRLSAITMALQYGSESEEDAALAAARYEEGESEAESITSFMDVSNPFYQLYDT
VRSCRNNQGQLIAEPFYHLPSKKKYPDYYQQIKMPISLQQIRTKLKNQEYETLDHLECDLNLMFENAKRYNVPNSAIYKRVLKLQQVMQA
KKKELARRDDIEDGDSMISSATSDTGSAKRKSKKNIRKQRMKILFNVVLEAREPGSGRRLCDLFMVKPSKKDYPDYYKIILEPMDLKIIE
HNIRNDKYAGEEGMIEDMKLMFRNARHYNEEGSQVYNDAHILEKLLKEKRKELGPLPDDDDMASPKLKLSRKSGISPKKSKYMTPMQQKL
NEVYEAVKNYTDKRGRRLSAIFLRLPSRSELPDYYLTIKKPMDMEKIRSHMMANKYQDIDSMVEDFVMMFNNACTYNEPESLIYKDALVL
HKVLLETRRDLEGDEDSHVPNVTLLIQELIHNLFVSVMSHQDDEGRCYSDSLAEIPAVDPNFPNKPPLTFDIIRKNVENNRYRRLDLFQE
HMFEVLERARRMNRTDSEIYEDAVELQQFFIKIRDELCKNGEILLSPALSYTTKHLHNDVEKERKEKLPKEIEEDKLKREEEKREAEKSE
DSSGAAGLSGLHRTYSQDCSFKNSMYHVGDYVYVEPAEANLQPHIVCIERLWEDSAGEKWLYGCWFYRPNETFHLATRKFLEKEVFKSDY
YNKVPVSKILGKCVVMFVKEYFKLCPENFRDEDVFVCESRYSAKTKSFKKIKLWTMPISSVRFVPRDVPLPVVRVASVFANADKGDDEKN
TDNSEDSRAEDNFNLEKEKEDVPVEMSNGEPGCHYFEQLHYNDMWLKVGDCVFIKSHGLVRPRVGRIEKVWVRDGAAYFYGPIFIHPEET
EHEPTKMFYKKEVFLSNLEETCPMTCILGKCAVLSFKDFLSCRPTEIPENDILLCESRYNESDKQMKKFKGLKRFSLSAKVVDDEIYYFR
KPIVPQKEPSPLLEKKIQLLEAKFAELEGGDDDIEEMGEEDSEVIEPPSLPQLQTPLASELDLMPYTPPQSTPKSAKGSAKKEGSKRKIN
MSGYILFSSEMRAVIKAQHPDYSFGELSRLVGTEWRNLETAKKAEYEGMMGGYPPGLPPLQGPVDGLVSMGSMQPLHPGGPPPHHLPPGV
PGLPGIPPPGVMNQGVAPMVGTPAPGGSPYGQQVGVLGPPGQQAPPPYPGPHPAGPPVIQQPTTPMFVAPPPKTQRLLHSEAYLKYIEGL
SAESNSISKWDQTLAVKRFREPKHERRPWRIWFLDTSKQAIGMLFIHFANVYLADLTEEDPCSLYLINFLLDATVGMLLIYVGVRAVSVL
VEWQQWESLRFGEYGDPLQCGAWVGQCALYIVIMIFEKSVVFIVLLILQWKKVALLNPIENPDLKLAIVMLIVPFFVNALMFWVVDNFLM
RKGKTKAKLEERGANQDSRNGSKVRYRRAASHEESESEILISADDEMEESDVEEDLRRLTPLKPVKKKKHRFGLPAGAQEAPIKKKRPPV

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>63012_63012_4_PBRM1-TMEM110-MUSTN1_PBRM1_chr3_52584437_ENST00000409057_TMEM110-MUSTN1_chr3_52889460_ENST00000504329_length(amino acids)=1896AA_BP=1575
MGSKRRRATSPSSSVSGDFDDGHHSVSTPGPSRKRRRLSNLPTVDPIAVCHELYNTIRDYKDEQGRLLCELFIRAPKRRNQPDYYEVVSQ
PIDLMKIQQKLKMEEYDDVNLLTADFQLLFNNAKSYYKPDSPEYKAACKLWDLYLRTRNEFVQKGEADDEDDDEDGQDNQGTVTEGSSPA
YLKEILEQLLEAIVVATNPSGRLISELFQKLPSKVQYPDYYAIIKEPIDLKTIAQRIQNGSYKSIHAMAKDIDLLAKNAKTYNEPGSQVF
KDANSIKKIFYMKKAEIEHHEMAKSSLRMRTPSNLAAARLTGPSHSKGSLGEERNPTSKYYRNKRAVQGGRLSAITMALQYGSESEEDAA
LAAARYEEGESEAESITSFMDVSNPFYQLYDTVRSCRNNQGQLIAEPFYHLPSKKKYPDYYQQIKMPISLQQIRTKLKNQEYETLDHLEC
DLNLMFENAKRYNVPNSAIYKRVLKLQQVMQAKKKELARRDDIEDGDSMISSATSDTGSAKRKSKKNIRKQRMKILFNVVLEAREPGSGR
RLCDLFMVKPSKKDYPDYYKIILEPMDLKIIEHNIRNDKYAGEEGMIEDMKLMFRNARHYNEEGSQVYNDAHILEKLLKEKRKELGPLPD
DDDMASPKLKLSRKSGISPKKSKYMTPMQQKLNEVYEAVKNYTDKRGRRLSAIFLRLPSRSELPDYYLTIKKPMDMEKIRSHMMANKYQD
IDSMVEDFVMMFNNACTYNEPESLIYKDALVLHKVLLETRRDLEGDEDSHVPNVTLLIQELIHNLFVSVMSHQDDEGRCYSDSLAEIPAV
DPNFPNKPPLTFDIIRKNVENNRYRRLDLFQEHMFEVLERARRMNRTDSEIYEDAVELQQFFIKIRDELCKNGEILLSPALSYTTKHLHN
DVEKERKEKLPKEIEEDKLKREEEKREAEKSEDSSGAAGLSGLHRTYSQDCSFKNSMYHVGDYVYVEPAEANLQPHIVCIERLWEDSAGE
KWLYGCWFYRPNETFHLATRKFLEKEVFKSDYYNKVPVSKILGKCVVMFVKEYFKLCPENFRDEDVFVCESRYSAKTKSFKKIKLWTMPI
SSVRFVPRDVPLPVVRVASVFANADKGDDEKNTDNSEDSRAEDNFNLEKEKEDVPVEMSNGEPGCHYFEQLHYNDMWLKVGDCVFIKSHG
LVRPRVGRIEKVWVRDGAAYFYGPIFIHPEETEHEPTKMFYKKEVFLSNLEETCPMTCILGKCAVLSFKDFLSCRPTEIPENDILLCESR
YNESDKQMKKFKGLKRFSLSAKVVDDEIYYFRKPIVPQKEPSPLLEKKIQLLEAKFAELEGGDDDIEEMGEEDSEVIEPPSLPQLQTPLA
SELDLMPYTPPQSTPKSAKGSAKKEGSKRKINMSGYILFSSEMRAVIKAQHPDYSFGELSRLVGTEWRNLETAKKAEYEGMMGGYPPGLP
PLQGPVDGLVSMGSMQPLHPGGPPPHHLPPGVPGLPGIPPPGVMNQGVAPMVGTPAPGGSPYGQQVGVLGPPGQQAPPPYPGPHPAGPPV
IQQPTTPMFVAPPPKTQRLLHSEAYLKYIEGLSAESNSISKWDQTLAVKRFREPKHERRPWRIWFLDTSKQAIGMLFIHFANVYLADLTE
EDPCSLYLINFLLDATVGMLLIYVGVRAVSVLVEWQQWESLRFGEYGDPLQCGAWVGQCALYIVIMIFEKSVVFIVLLILQWKKVALLNP
IENPDLKLAIVMLIVPFFVNALMFWVVDNFLMRKGKTKAKLEERGANQDSRNGSKVRYRRAASHEESESEILISADDEMEESDVEEDLRR
LTPLKPVKKKKHRFGLPAGAQEAPIKKKRPPVKDEDLKGARGNLTKNQEIKSKTYQVMRECEQAGSAAPSVFSRTRTGTETVFEKPKAGP

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>63012_63012_5_PBRM1-TMEM110-MUSTN1_PBRM1_chr3_52584437_ENST00000409114_TMEM110-MUSTN1_chr3_52889460_ENST00000504329_length(amino acids)=1914AA_BP=1593
MGSKRRRATSPSSSVSGDFDDGHHSVSTPGPSRKRRRLSNLPTVDPIAVCHELYNTIRDYKDEQGRLLCELFIRAPKRRNQPDYYEVVSQ
PIDLMKIQQKLKMEEYDDVNLLTADFQLLFNNAKSYYKPDSPEYKAACKLWDLYLRTRNEFVQKGEADDEDDDEDGQDNQGTVTEGSSPA
YLKEILEQLLEAIVVATNPSGRLISELFQKLPSKVQYPDYYAIIKEPIDLKTIAQRIQNGSYKSIHAMAKDIDLLAKNAKTYNEPGSQVF
KDANSIKKIFYMKKAEIEHHEMAKSSLRMRTPSNLAAARLTGPSHSKGSLGEERNPTSKYYRNKRAVQGGRLSAITMALQYGSESEEDAA
LAAARYEEGESEAESITSFMDVSNPFYQLYDTVRSCRNNQGQLIAEPFYHLPSKKKYPDYYQQIKMPISLQQIRTKLKNQEYETLDHLEC
DLNLMFENAKRYNVPNSAIYKRVLKLQQVMQAKKKELARRDDIEDGDSMISSATSDTGSAKRKRNTHDSEMLGLRRLSSKKNIRKQRMKI
LFNVVLEAREPGSGRRLCDLFMVKPSKKDYPDYYKIILEPMDLKIIEHNIRNDKYAGEEGMIEDMKLMFRNARHYNEEGSQVYNDAHILE
KLLKEKRKELGPLPDDDDMASPKLKLSRKSGISPKKSKYMTPMQQKLNEVYEAVKNYTDKRGRRLSAIFLRLPSRSELPDYYLTIKKPMD
MEKIRSHMMANKYQDIDSMVEDFVMMFNNACTYNEPESLIYKDALVLHKVLLETRRDLEGDEDSHVPNVTLLIQELIHNLFVSVMSHQDD
EGRCYSDSLAEIPAVDPNFPNKPPLTFDIIRKNVENNRYRRLDLFQEHMFEVLERARRMNRTDSEIYEDAVELQQFFIKIRDELCKNGEI
LLSPALSYTTKHLHNDVEKERKEKLPKEIEEDKLKREEEKREAEKSEDSSGAAGLSGLHRTYSQDCSFKNSMYHVGDYVYVEPAEANLQP
HIVCIERLWEDSAGEKWLYGCWFYRPNETFHLATRKFLEKEVFKSDYYNKVPVSKILGKCVVMFVKEYFKLCPENFRDEDVFVCESRYSA
KTKSFKKIKLWTMPISSVRFVPRDVPLPVVRVASVFANADKGDDEKNTDNSEDSRAEDNFNLEKEKEDVPVEMSNGEPGCHYFEQLHYND
MWLKVGDCVFIKSHGLVRPRVGRIEKVWVRDGAAYFYGPIFIHPEETEHEPTKMFYKKEVFLSNLEETCPMTCILGKCAVLSFKDFLSCR
PTEIPENDILLCESRYNESDKQMKKFKGLKRFSLSAKVVDDEIYYFRKPIVPQKEPSPLLEKKIQLLEAKFAELEGGDDDIEEMGEEDSE
VIEPPSLPQLQTPLASELDLMPYTPPQSTPKSAKGSAKKEGSKRKINMSGYILFSSEMRAVIKAQHPDYSFGELSRLVGTEWRNLETAKK
AEYEERAAKVAEQQERERAAQQQQPSASPRAGTPVGALMGVVPPPTPMGMLNQQLTPVAGVMNQGVAPMVGTPAPGGSPYGQQVGVLGPP
GQQAPPPYPGPHPAGPPVIQQPTTPMFVAPPPKTQRLLHSEAYLKYIEGLSAESNSISKWDQTLAVKRFREPKHERRPWRIWFLDTSKQA
IGMLFIHFANVYLADLTEEDPCSLYLINFLLDATVGMLLIYVGVRAVSVLVEWQQWESLRFGEYGDPLQCGAWVGQCALYIVIMIFEKSV
VFIVLLILQWKKVALLNPIENPDLKLAIVMLIVPFFVNALMFWVVDNFLMRKGKTKAKLEERGANQDSRNGSKVRYRRAASHEESESEIL
ISADDEMEESDVEEDLRRLTPLKPVKKKKHRFGLPAGAQEAPIKKKRPPVKDEDLKGARGNLTKNQEIKSKTYQVMRECEQAGSAAPSVF

--------------------------------------------------------------

>63012_63012_6_PBRM1-TMEM110-MUSTN1_PBRM1_chr3_52584437_ENST00000409767_TMEM110-MUSTN1_chr3_52889460_ENST00000504329_length(amino acids)=1859AA_BP=1538
MGSKRRRATSPSSSVSGDFDDGHHSVSTPGPSRKRRRLSNLPTVDPIAVCHELYNTIRDYKDEQGRLLCELFIRAPKRRNQPDYYEVVSQ
PIDLMKIQQKLKMEEYDDVNLLTADFQLLFNNAKSYYKPDSPEYKAACKLWDLYLRTRNEFVQKGEADDEDDDEDGQDNQGTVTEGSSPA
YLKEILEQLLEAIVVATNPSGRLISELFQKLPSKVQYPDYYAIIKEPIDLKTIAQRIQNGSYKSIHAMAKDIDLLAKNAKTYNEPGSQVF
KDANSIKKIFYMKKAEIEHHEMAKSSLRMRTPSNLAAARLTGPSHSKGSLGEERNPTSKYYRNKRAVQGGRLSAITMALQYGSESEEDAA
LAAARYEEGESEAESITSFMDVSNPFYQLYDTVRSCRNNQGQLIAEPFYHLPSKKKYPDYYQQIKMPISLQQIRTKLKNQEYETLDHLEC
DLNLMFENAKRYNVPNSAIYKRVLKLQQVMQAKKKELARRDDIEDGDSMISSATSDTGSAKRKRNTHDSEMLGLRRLSSKKNIRKQRMKI
LFNVVLEAREPGSGRRLCDLFMVKPSKKDYPDYYKIILEPMDLKIIEHNIRNDKYAGEEGMIEDMKLMFRNARHYNEEGSQVYNDAHILE
KLLKEKRKELGPLPDDDDMASPKLKLSRKSGISPKKSKYMTPMQQKLNEVYEAVKNYTDKRGRRLSAIFLRLPSRSELPDYYLTIKKPMD
MEKIRSHMMANKYQDIDSMVEDFVMMFNNACTYNEPESLIYKDALVLHKVLLETRRDLEGDEDSHVPNVTLLIQELIHNLFVSVMSHQDD
EGRCYSDSLAEIPAVDPNFPNKPPLTFDIIRKNVENNRYRRLDLFQEHMFEVLERARRMNRTDSEIYEDAVELQQFFIKIRDELCKNGEI
LLSPALSYTTKHLHNDVEKERKEKLPKEIEEDKLKREEEKREAEKSEDSSGAAGLSGLHRTYSQDCSFKNSMYHVGDYVYVEPAEANLQP
HIVCIERLWEDSAGEKWLYGCWFYRPNETFHLATRKFLEKEVFKSDYYNKVPVSKILGKCVVMFVKEYFKLCPENFRDEDVFVCESRYSA
KTKSFKKIKLWTMPISSVRFVPRDVPLPVVRVASVFANADKGDDEKNTDNSEDSRAEDNFNLEKEKEDVPVEMSNGEPGCHYFEQLHYND
MWLKVGDCVFIKSHGLVRPRVGRIEKVWVRDGAAYFYGPIFIHPEETEHEPTKMFYKKEVFLSNLEETCPMTCILGKCAVLSFKDFLSCR
PTEIPENDILLCESRYNESDKQMKKFKGLKRFSLSAKVVDDEIYYFRKPIVPQKEPSPLLEKKIQLLEAKFAELEGGDDDIEEMGEEDSE
VIEPPSLPQLQTPLASELDLMPYTPPQSTPKSAKGSAKKEGSKRKINMSGYILFSSEMRAVIKAQHPDYSFGELSRLVGTEWRNLETAKK
AEYEGVMNQGVAPMVGTPAPGGSPYGQQVGVLGPPGQQAPPPYPGPHPAGPPVIQQPTTPMFVAPPPKTQRLLHSEAYLKYIEGLSAESN
SISKWDQTLAVKRFREPKHERRPWRIWFLDTSKQAIGMLFIHFANVYLADLTEEDPCSLYLINFLLDATVGMLLIYVGVRAVSVLVEWQQ
WESLRFGEYGDPLQCGAWVGQCALYIVIMIFEKSVVFIVLLILQWKKVALLNPIENPDLKLAIVMLIVPFFVNALMFWVVDNFLMRKGKT
KAKLEERGANQDSRNGSKVRYRRAASHEESESEILISADDEMEESDVEEDLRRLTPLKPVKKKKHRFGLPAGAQEAPIKKKRPPVKDEDL

--------------------------------------------------------------

>63012_63012_7_PBRM1-TMEM110-MUSTN1_PBRM1_chr3_52584437_ENST00000410007_TMEM110-MUSTN1_chr3_52889460_ENST00000504329_length(amino acids)=1871AA_BP=1550
MGSKRRRATSPSSSVSGDFDDGHHSVSTPGPSRKRRRLSNLPTVDPIAVCHELYNTIRDYKDEQGRLLCELFIRAPKRRNQPDYYEVVSQ
PIDLMKIQQKLKMEEYDDVNLLTADFQLLFNNAKSYYKPDSPEYKAACKLWDLYLRTRNEFVQKGEADDEDDDEDGQDNQGTVTEGSSPA
YLKEILEQLLEAIVVATNPSGRLISELFQKLPSKVQYPDYYAIIKEPIDLKTIAQRIQNGSYKSIHAMAKDIDLLAKNAKTYNEPGSQVF
KDANSIKKIFYMKKAEIEHHEMAKSSLRMRTPSNLAAARLTGPSHSKGSLGEERNPTSKYYRNKRAVQGGRLSAITMALQYGSESEEDAA
LAAARYEEGESEAESITSFMDVSNPFYQLYDTVRSCRNNQGQLIAEPFYHLPSKKKYPDYYQQIKMPISLQQIRTKLKNQEYETLDHLEC
DLNLMFENAKRYNVPNSAIYKRVLKLQQVMQAKKKELARRDDIEDGDSMISSATSDTGSAKRKSKKNIRKQRMKILFNVVLEAREPGSGR
RLCDLFMVKPSKKDYPDYYKIILEPMDLKIIEHNIRNDKYAGEEGMIEDMKLMFRNARHYNEEGSQVYNDAHILEKLLKEKRKELGPLPD
DDDMASPKLKLSRKSGISPKKSKYMTPMQQKLNEVYEAVKNYTDKRGRRLSAIFLRLPSRSELPDYYLTIKKPMDMEKIRSHMMANKYQD
IDSMVEDFVMMFNNACTYNEPESLIYKDALVLHKVLLETRRDLEGDEDSHVPNVTLLIQELIHNLFVSVMSHQDDEGRCYSDSLAEIPAV
DPNFPNKPPLTFDIIRKNVENNRYRRLDLFQEHMFEVLERARRMNRTDSEIYEDAVELQQFFIKIRDELCKNGEILLSPALSYTTKHLHN
DVEKERKEKLPKEIEEDKLKREEEKREAEKSEDSSGAAGLSGLHRTYSQDCSFKNSMYHVGDYVYVEPAEANLQPHIVCIERLWEDSAEK
EVFKSDYYNKVPVSKILGKCVVMFVKEYFKLCPENFRDEDVFVCESRYSAKTKSFKKIKLWTMPISSVRFVPRDVPLPVVRVASVFANAD
KGDDEKNTDNSEDSRAEDNFNLEKEKEDVPVEMSNGEPGCHYFEQLHYNDMWLKVGDCVFIKSHGLVRPRVGRIEKVWVRDGAAYFYGPI
FIHPEETEHEPTKMFYKKEVFLSNLEETCPMTCILGKCAVLSFKDFLSCRPTEIPENDILLCESRYNESDKQMKKFKGLKRFSLSAKVVD
DEIYYFRKPIVPQKEPSPLLEKKIQLLEAKFAELEGGDDDIEEMGEEDSEVIEPPSLPQLQTPLASELDLMPYTPPQSTPKSAKGSAKKE
GSKRKINMSGYILFSSEMRAVIKAQHPDYSFGELSRLVGTEWRNLETAKKAEYEGMMGGYPPGLPPLQGPVDGLVSMGSMQPLHPGGPPP
HHLPPGVPGLPGIPPPGVMNQGVAPMVGTPAPGGSPYGQQVGVLGPPGQQAPPPYPGPHPAGPPVIQQPTTPMFVAPPPKTQRLLHSEAY
LKYIEGLSAESNSISKWDQTLAVKRFREPKHERRPWRIWFLDTSKQAIGMLFIHFANVYLADLTEEDPCSLYLINFLLDATVGMLLIYVG
VRAVSVLVEWQQWESLRFGEYGDPLQCGAWVGQCALYIVIMIFEKSVVFIVLLILQWKKVALLNPIENPDLKLAIVMLIVPFFVNALMFW
VVDNFLMRKGKTKAKLEERGANQDSRNGSKVRYRRAASHEESESEILISADDEMEESDVEEDLRRLTPLKPVKKKKHRFGLPAGAQEAPI

--------------------------------------------------------------

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr3:52584437/chr3:52889460)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePBRM1chr3:52584437chr3:52889460ENST00000296302-29301468_15991632.33333333333331690.0Compositional biasNote=Pro-rich
HgenePBRM1chr3:52584437chr3:52889460ENST00000296302-2930630_6331632.33333333333331690.0Compositional biasNote=Poly-Asp
HgenePBRM1chr3:52584437chr3:52889460ENST00000337303-2728630_6331525.33333333333331583.0Compositional biasNote=Poly-Asp
HgenePBRM1chr3:52584437chr3:52889460ENST00000356770-2728630_6331545.33333333333331603.0Compositional biasNote=Poly-Asp
HgenePBRM1chr3:52584437chr3:52889460ENST00000394830-2930630_6331525.33333333333331583.0Compositional biasNote=Poly-Asp
HgenePBRM1chr3:52584437chr3:52889460ENST00000409057-2829630_6331577.33333333333331635.0Compositional biasNote=Poly-Asp
HgenePBRM1chr3:52584437chr3:52889460ENST00000409114-2930630_6331595.33333333333331653.0Compositional biasNote=Poly-Asp
HgenePBRM1chr3:52584437chr3:52889460ENST00000409767-2829630_6331540.33333333333331598.0Compositional biasNote=Poly-Asp
HgenePBRM1chr3:52584437chr3:52889460ENST00000410007-2829630_6331552.33333333333331610.0Compositional biasNote=Poly-Asp
HgenePBRM1chr3:52584437chr3:52889460ENST00000296302-29301379_14471632.33333333333331690.0DNA bindingHMG box
HgenePBRM1chr3:52584437chr3:52889460ENST00000337303-27281379_14471525.33333333333331583.0DNA bindingHMG box
HgenePBRM1chr3:52584437chr3:52889460ENST00000356770-27281379_14471545.33333333333331603.0DNA bindingHMG box
HgenePBRM1chr3:52584437chr3:52889460ENST00000394830-29301379_14471525.33333333333331583.0DNA bindingHMG box
HgenePBRM1chr3:52584437chr3:52889460ENST00000409057-28291379_14471577.33333333333331635.0DNA bindingHMG box
HgenePBRM1chr3:52584437chr3:52889460ENST00000409114-29301379_14471595.33333333333331653.0DNA bindingHMG box
HgenePBRM1chr3:52584437chr3:52889460ENST00000409767-28291379_14471540.33333333333331598.0DNA bindingHMG box
HgenePBRM1chr3:52584437chr3:52889460ENST00000410007-28291379_14471552.33333333333331610.0DNA bindingHMG box
HgenePBRM1chr3:52584437chr3:52889460ENST00000296302-29301156_12721632.33333333333331690.0DomainBAH 2
HgenePBRM1chr3:52584437chr3:52889460ENST00000296302-2930200_2701632.33333333333331690.0DomainBromo 2
HgenePBRM1chr3:52584437chr3:52889460ENST00000296302-2930400_4701632.33333333333331690.0DomainBromo 3
HgenePBRM1chr3:52584437chr3:52889460ENST00000296302-2930538_6081632.33333333333331690.0DomainBromo 4
HgenePBRM1chr3:52584437chr3:52889460ENST00000296302-293064_1341632.33333333333331690.0DomainBromo 1
HgenePBRM1chr3:52584437chr3:52889460ENST00000296302-2930676_7461632.33333333333331690.0DomainBromo 5
HgenePBRM1chr3:52584437chr3:52889460ENST00000296302-2930792_8621632.33333333333331690.0DomainBromo 6
HgenePBRM1chr3:52584437chr3:52889460ENST00000296302-2930956_10741632.33333333333331690.0DomainBAH 1
HgenePBRM1chr3:52584437chr3:52889460ENST00000337303-27281156_12721525.33333333333331583.0DomainBAH 2
HgenePBRM1chr3:52584437chr3:52889460ENST00000337303-2728200_2701525.33333333333331583.0DomainBromo 2
HgenePBRM1chr3:52584437chr3:52889460ENST00000337303-2728400_4701525.33333333333331583.0DomainBromo 3
HgenePBRM1chr3:52584437chr3:52889460ENST00000337303-2728538_6081525.33333333333331583.0DomainBromo 4
HgenePBRM1chr3:52584437chr3:52889460ENST00000337303-272864_1341525.33333333333331583.0DomainBromo 1
HgenePBRM1chr3:52584437chr3:52889460ENST00000337303-2728676_7461525.33333333333331583.0DomainBromo 5
HgenePBRM1chr3:52584437chr3:52889460ENST00000337303-2728792_8621525.33333333333331583.0DomainBromo 6
HgenePBRM1chr3:52584437chr3:52889460ENST00000337303-2728956_10741525.33333333333331583.0DomainBAH 1
HgenePBRM1chr3:52584437chr3:52889460ENST00000356770-27281156_12721545.33333333333331603.0DomainBAH 2
HgenePBRM1chr3:52584437chr3:52889460ENST00000356770-2728200_2701545.33333333333331603.0DomainBromo 2
HgenePBRM1chr3:52584437chr3:52889460ENST00000356770-2728400_4701545.33333333333331603.0DomainBromo 3
HgenePBRM1chr3:52584437chr3:52889460ENST00000356770-2728538_6081545.33333333333331603.0DomainBromo 4
HgenePBRM1chr3:52584437chr3:52889460ENST00000356770-272864_1341545.33333333333331603.0DomainBromo 1
HgenePBRM1chr3:52584437chr3:52889460ENST00000356770-2728676_7461545.33333333333331603.0DomainBromo 5
HgenePBRM1chr3:52584437chr3:52889460ENST00000356770-2728792_8621545.33333333333331603.0DomainBromo 6
HgenePBRM1chr3:52584437chr3:52889460ENST00000356770-2728956_10741545.33333333333331603.0DomainBAH 1
HgenePBRM1chr3:52584437chr3:52889460ENST00000394830-29301156_12721525.33333333333331583.0DomainBAH 2
HgenePBRM1chr3:52584437chr3:52889460ENST00000394830-2930200_2701525.33333333333331583.0DomainBromo 2
HgenePBRM1chr3:52584437chr3:52889460ENST00000394830-2930400_4701525.33333333333331583.0DomainBromo 3
HgenePBRM1chr3:52584437chr3:52889460ENST00000394830-2930538_6081525.33333333333331583.0DomainBromo 4
HgenePBRM1chr3:52584437chr3:52889460ENST00000394830-293064_1341525.33333333333331583.0DomainBromo 1
HgenePBRM1chr3:52584437chr3:52889460ENST00000394830-2930676_7461525.33333333333331583.0DomainBromo 5
HgenePBRM1chr3:52584437chr3:52889460ENST00000394830-2930792_8621525.33333333333331583.0DomainBromo 6
HgenePBRM1chr3:52584437chr3:52889460ENST00000394830-2930956_10741525.33333333333331583.0DomainBAH 1
HgenePBRM1chr3:52584437chr3:52889460ENST00000409057-28291156_12721577.33333333333331635.0DomainBAH 2
HgenePBRM1chr3:52584437chr3:52889460ENST00000409057-2829200_2701577.33333333333331635.0DomainBromo 2
HgenePBRM1chr3:52584437chr3:52889460ENST00000409057-2829400_4701577.33333333333331635.0DomainBromo 3
HgenePBRM1chr3:52584437chr3:52889460ENST00000409057-2829538_6081577.33333333333331635.0DomainBromo 4
HgenePBRM1chr3:52584437chr3:52889460ENST00000409057-282964_1341577.33333333333331635.0DomainBromo 1
HgenePBRM1chr3:52584437chr3:52889460ENST00000409057-2829676_7461577.33333333333331635.0DomainBromo 5
HgenePBRM1chr3:52584437chr3:52889460ENST00000409057-2829792_8621577.33333333333331635.0DomainBromo 6
HgenePBRM1chr3:52584437chr3:52889460ENST00000409057-2829956_10741577.33333333333331635.0DomainBAH 1
HgenePBRM1chr3:52584437chr3:52889460ENST00000409114-29301156_12721595.33333333333331653.0DomainBAH 2
HgenePBRM1chr3:52584437chr3:52889460ENST00000409114-2930200_2701595.33333333333331653.0DomainBromo 2
HgenePBRM1chr3:52584437chr3:52889460ENST00000409114-2930400_4701595.33333333333331653.0DomainBromo 3
HgenePBRM1chr3:52584437chr3:52889460ENST00000409114-2930538_6081595.33333333333331653.0DomainBromo 4
HgenePBRM1chr3:52584437chr3:52889460ENST00000409114-293064_1341595.33333333333331653.0DomainBromo 1
HgenePBRM1chr3:52584437chr3:52889460ENST00000409114-2930676_7461595.33333333333331653.0DomainBromo 5
HgenePBRM1chr3:52584437chr3:52889460ENST00000409114-2930792_8621595.33333333333331653.0DomainBromo 6
HgenePBRM1chr3:52584437chr3:52889460ENST00000409114-2930956_10741595.33333333333331653.0DomainBAH 1
HgenePBRM1chr3:52584437chr3:52889460ENST00000409767-28291156_12721540.33333333333331598.0DomainBAH 2
HgenePBRM1chr3:52584437chr3:52889460ENST00000409767-2829200_2701540.33333333333331598.0DomainBromo 2
HgenePBRM1chr3:52584437chr3:52889460ENST00000409767-2829400_4701540.33333333333331598.0DomainBromo 3
HgenePBRM1chr3:52584437chr3:52889460ENST00000409767-2829538_6081540.33333333333331598.0DomainBromo 4
HgenePBRM1chr3:52584437chr3:52889460ENST00000409767-282964_1341540.33333333333331598.0DomainBromo 1
HgenePBRM1chr3:52584437chr3:52889460ENST00000409767-2829676_7461540.33333333333331598.0DomainBromo 5
HgenePBRM1chr3:52584437chr3:52889460ENST00000409767-2829792_8621540.33333333333331598.0DomainBromo 6
HgenePBRM1chr3:52584437chr3:52889460ENST00000409767-2829956_10741540.33333333333331598.0DomainBAH 1
HgenePBRM1chr3:52584437chr3:52889460ENST00000410007-28291156_12721552.33333333333331610.0DomainBAH 2
HgenePBRM1chr3:52584437chr3:52889460ENST00000410007-2829200_2701552.33333333333331610.0DomainBromo 2
HgenePBRM1chr3:52584437chr3:52889460ENST00000410007-2829400_4701552.33333333333331610.0DomainBromo 3
HgenePBRM1chr3:52584437chr3:52889460ENST00000410007-2829538_6081552.33333333333331610.0DomainBromo 4
HgenePBRM1chr3:52584437chr3:52889460ENST00000410007-282964_1341552.33333333333331610.0DomainBromo 1
HgenePBRM1chr3:52584437chr3:52889460ENST00000410007-2829676_7461552.33333333333331610.0DomainBromo 5
HgenePBRM1chr3:52584437chr3:52889460ENST00000410007-2829792_8621552.33333333333331610.0DomainBromo 6
HgenePBRM1chr3:52584437chr3:52889460ENST00000410007-2829956_10741552.33333333333331610.0DomainBAH 1

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePBRM1chr3:52584437chr3:52889460ENST00000337303-27281468_15991525.33333333333331583.0Compositional biasNote=Pro-rich
HgenePBRM1chr3:52584437chr3:52889460ENST00000356770-27281468_15991545.33333333333331603.0Compositional biasNote=Pro-rich
HgenePBRM1chr3:52584437chr3:52889460ENST00000394830-29301468_15991525.33333333333331583.0Compositional biasNote=Pro-rich
HgenePBRM1chr3:52584437chr3:52889460ENST00000409057-28291468_15991577.33333333333331635.0Compositional biasNote=Pro-rich
HgenePBRM1chr3:52584437chr3:52889460ENST00000409114-29301468_15991595.33333333333331653.0Compositional biasNote=Pro-rich
HgenePBRM1chr3:52584437chr3:52889460ENST00000409767-28291468_15991540.33333333333331598.0Compositional biasNote=Pro-rich
HgenePBRM1chr3:52584437chr3:52889460ENST00000410007-28291468_15991552.33333333333331610.0Compositional biasNote=Pro-rich


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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
PBRM1
TMEM110-MUSTN1


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to PBRM1-TMEM110-MUSTN1


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to PBRM1-TMEM110-MUSTN1


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource