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Center for Computational Systems Medicine level1
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:PBX1-RFWD2

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: PBX1-RFWD2
FusionPDB ID: 63030
FusionGDB2.0 ID: 63030
HgeneTgene
Gene symbol

PBX1

RFWD2

Gene ID

5087

64326

Gene namePBX homeobox 1COP1 E3 ubiquitin ligase
SynonymsCAKUHEDCFAP78|FAP78|RFWD2|RNF200
Cytomap

1q23.3

1q25.1-q25.2

Type of geneprotein-codingprotein-coding
Descriptionpre-B-cell leukemia transcription factor 1homeobox protein PBX1homeobox protein PRLpre-B-cell leukemia homeobox 1E3 ubiquitin-protein ligase COP1E3 ubiquitin-protein ligase RFWD2RING finger protein 200RING-type E3 ubiquitin transferase RFWD2constitutive photomorphogenesis protein 1 homologconstitutive photomorphogenic protein 1putative ubiquitin ligase COP1ri
Modification date2020031320200313
UniProtAcc

P40424

.
Ensembl transtripts involved in fusion geneENST idsENST00000367897, ENST00000401534, 
ENST00000420696, ENST00000540236, 
ENST00000559240, ENST00000474046, 
ENST00000485769, ENST00000540246, 
ENST00000560641, 
ENST00000308769, 
ENST00000367669, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score16 X 10 X 5=80028 X 17 X 12=5712
# samples 2127
** MAII scorelog2(21/800*10)=-1.9296106721086
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(27/5712*10)=-4.40296466697827
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: PBX1 [Title/Abstract] AND RFWD2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)PBX1(164532548)-RFWD2(175958615), # samples:2
Anticipated loss of major functional domain due to fusion event.PBX1-RFWD2 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
PBX1-RFWD2 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
PBX1-RFWD2 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
PBX1-RFWD2 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneRFWD2

GO:0010212

response to ionizing radiation

19805145


check buttonFusion gene breakpoints across PBX1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across RFWD2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4SARCTCGA-DX-A6YR-01APBX1chr1

164532548

-RFWD2chr1

175958615

-
ChimerDB4SARCTCGA-DX-A6YR-01APBX1chr1

164532548

+RFWD2chr1

175958615

-


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)
BP loci
(transcript)
Predicted start
(transcript)
Predicted stop
(transcript)
Seq length
(amino acids)
ENST00000420696PBX1chr1164532548+ENST00000367669RFWD2chr1175958615-1242453182919245
ENST00000420696PBX1chr1164532548+ENST00000308769RFWD2chr1175958615-920453182919246
ENST00000401534PBX1chr1164532548+ENST00000367669RFWD2chr1175958615-10542650731243
ENST00000401534PBX1chr1164532548+ENST00000308769RFWD2chr1175958615-7322650731243
ENST00000559240PBX1chr1164532548+ENST00000367669RFWD2chr1175958615-10542650731243
ENST00000559240PBX1chr1164532548+ENST00000308769RFWD2chr1175958615-7322650731243
ENST00000367897PBX1chr1164532548+ENST00000367669RFWD2chr1175958615-10542650731243
ENST00000367897PBX1chr1164532548+ENST00000308769RFWD2chr1175958615-7322650731243
ENST00000540236PBX1chr1164532548+ENST00000367669RFWD2chr1175958615-10542650731243
ENST00000540236PBX1chr1164532548+ENST00000308769RFWD2chr1175958615-7322650731243

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000420696ENST00000367669PBX1chr1164532548+RFWD2chr1175958615-0.0008617530.99913824
ENST00000420696ENST00000308769PBX1chr1164532548+RFWD2chr1175958615-0.0011369030.9988631
ENST00000401534ENST00000367669PBX1chr1164532548+RFWD2chr1175958615-0.0006824980.9993175
ENST00000401534ENST00000308769PBX1chr1164532548+RFWD2chr1175958615-0.0009877170.99901223
ENST00000559240ENST00000367669PBX1chr1164532548+RFWD2chr1175958615-0.0006824980.9993175
ENST00000559240ENST00000308769PBX1chr1164532548+RFWD2chr1175958615-0.0009877170.99901223
ENST00000367897ENST00000367669PBX1chr1164532548+RFWD2chr1175958615-0.0006824980.9993175
ENST00000367897ENST00000308769PBX1chr1164532548+RFWD2chr1175958615-0.0009877170.99901223
ENST00000540236ENST00000367669PBX1chr1164532548+RFWD2chr1175958615-0.0006824980.9993175
ENST00000540236ENST00000308769PBX1chr1164532548+RFWD2chr1175958615-0.0009877170.99901223

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>63030_63030_1_PBX1-RFWD2_PBX1_chr1_164532548_ENST00000367897_RFWD2_chr1_175958615_ENST00000308769_length(amino acids)=243AA_BP=88
MDEQPRLMHSHAGVGMAGHPGLSQHLQDGAGGTEGEGGRKQDIGDILQQIMTITDQSLDEAQARKHALNCHRMKPALFNVLCEIKEKTDH
CVHYYDLRNTKQPIMVFKGHRKAVSYAKFVSGEEIVSASTDSQLKLWNVGKPYCLRSFKGHINEKNFVGLASNGDYIACGSENNSLYLYY

--------------------------------------------------------------

>63030_63030_2_PBX1-RFWD2_PBX1_chr1_164532548_ENST00000367897_RFWD2_chr1_175958615_ENST00000367669_length(amino acids)=243AA_BP=88
MDEQPRLMHSHAGVGMAGHPGLSQHLQDGAGGTEGEGGRKQDIGDILQQIMTITDQSLDEAQARKHALNCHRMKPALFNVLCEIKEKTDH
CVHYYDLRNTKQPIMVFKGHRKAVSYAKFVSGEEIVSASTDSQLKLWNVGKPYCLRSFKGHINEKNFVGLASNGDYIACGSENNSLYLYY

--------------------------------------------------------------

>63030_63030_3_PBX1-RFWD2_PBX1_chr1_164532548_ENST00000401534_RFWD2_chr1_175958615_ENST00000308769_length(amino acids)=243AA_BP=88
MDEQPRLMHSHAGVGMAGHPGLSQHLQDGAGGTEGEGGRKQDIGDILQQIMTITDQSLDEAQARKHALNCHRMKPALFNVLCEIKEKTDH
CVHYYDLRNTKQPIMVFKGHRKAVSYAKFVSGEEIVSASTDSQLKLWNVGKPYCLRSFKGHINEKNFVGLASNGDYIACGSENNSLYLYY

--------------------------------------------------------------

>63030_63030_4_PBX1-RFWD2_PBX1_chr1_164532548_ENST00000401534_RFWD2_chr1_175958615_ENST00000367669_length(amino acids)=243AA_BP=88
MDEQPRLMHSHAGVGMAGHPGLSQHLQDGAGGTEGEGGRKQDIGDILQQIMTITDQSLDEAQARKHALNCHRMKPALFNVLCEIKEKTDH
CVHYYDLRNTKQPIMVFKGHRKAVSYAKFVSGEEIVSASTDSQLKLWNVGKPYCLRSFKGHINEKNFVGLASNGDYIACGSENNSLYLYY

--------------------------------------------------------------

>63030_63030_5_PBX1-RFWD2_PBX1_chr1_164532548_ENST00000420696_RFWD2_chr1_175958615_ENST00000308769_length(amino acids)=246AA_BP=90
MEMDEQPRLMHSHAGVGMAGHPGLSQHLQDGAGGTEGEGGRKQDIGDILQQIMTITDQSLDEAQARKHALNCHRMKPALFNVLCEIKEKT
DHCVHYYDLRNTKQPIMVFKGHRKAVSYAKFVSGEEIVSASTDSQLKLWNVGKPYCLRSFKGHINEKNFVGLASNGDYIACGSENNSLYL

--------------------------------------------------------------

>63030_63030_6_PBX1-RFWD2_PBX1_chr1_164532548_ENST00000420696_RFWD2_chr1_175958615_ENST00000367669_length(amino acids)=245AA_BP=90
MEMDEQPRLMHSHAGVGMAGHPGLSQHLQDGAGGTEGEGGRKQDIGDILQQIMTITDQSLDEAQARKHALNCHRMKPALFNVLCEIKEKT
DHCVHYYDLRNTKQPIMVFKGHRKAVSYAKFVSGEEIVSASTDSQLKLWNVGKPYCLRSFKGHINEKNFVGLASNGDYIACGSENNSLYL

--------------------------------------------------------------

>63030_63030_7_PBX1-RFWD2_PBX1_chr1_164532548_ENST00000540236_RFWD2_chr1_175958615_ENST00000308769_length(amino acids)=243AA_BP=88
MDEQPRLMHSHAGVGMAGHPGLSQHLQDGAGGTEGEGGRKQDIGDILQQIMTITDQSLDEAQARKHALNCHRMKPALFNVLCEIKEKTDH
CVHYYDLRNTKQPIMVFKGHRKAVSYAKFVSGEEIVSASTDSQLKLWNVGKPYCLRSFKGHINEKNFVGLASNGDYIACGSENNSLYLYY

--------------------------------------------------------------

>63030_63030_8_PBX1-RFWD2_PBX1_chr1_164532548_ENST00000540236_RFWD2_chr1_175958615_ENST00000367669_length(amino acids)=243AA_BP=88
MDEQPRLMHSHAGVGMAGHPGLSQHLQDGAGGTEGEGGRKQDIGDILQQIMTITDQSLDEAQARKHALNCHRMKPALFNVLCEIKEKTDH
CVHYYDLRNTKQPIMVFKGHRKAVSYAKFVSGEEIVSASTDSQLKLWNVGKPYCLRSFKGHINEKNFVGLASNGDYIACGSENNSLYLYY

--------------------------------------------------------------

>63030_63030_9_PBX1-RFWD2_PBX1_chr1_164532548_ENST00000559240_RFWD2_chr1_175958615_ENST00000308769_length(amino acids)=243AA_BP=88
MDEQPRLMHSHAGVGMAGHPGLSQHLQDGAGGTEGEGGRKQDIGDILQQIMTITDQSLDEAQARKHALNCHRMKPALFNVLCEIKEKTDH
CVHYYDLRNTKQPIMVFKGHRKAVSYAKFVSGEEIVSASTDSQLKLWNVGKPYCLRSFKGHINEKNFVGLASNGDYIACGSENNSLYLYY

--------------------------------------------------------------

>63030_63030_10_PBX1-RFWD2_PBX1_chr1_164532548_ENST00000559240_RFWD2_chr1_175958615_ENST00000367669_length(amino acids)=243AA_BP=88
MDEQPRLMHSHAGVGMAGHPGLSQHLQDGAGGTEGEGGRKQDIGDILQQIMTITDQSLDEAQARKHALNCHRMKPALFNVLCEIKEKTDH
CVHYYDLRNTKQPIMVFKGHRKAVSYAKFVSGEEIVSASTDSQLKLWNVGKPYCLRSFKGHINEKNFVGLASNGDYIACGSENNSLYLYY

--------------------------------------------------------------

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr1:164532548/chr1:175958615)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
PBX1

P40424

.
FUNCTION: Transcription factor which binds the DNA sequence 5'-TGATTGAT-3' as part of a heterodimer with HOX proteins such as HOXA1, HOXA5, HOXB7 and HOXB8 (PubMed:9191052). Binds to the DNA sequence 5'-TGATTGAC-3' in complex with a nuclear factor which is not a class I HOX protein (PubMed:9191052). Has also been shown to bind the DNA sequence 5'-ATCAATCAA-3' cooperatively with HOXA5, HOXB7, HOXB8, HOXC8 and HOXD4 (PubMed:8327485, PubMed:7791786). Acts as a transcriptional activator of PF4 in complex with MEIS1 (PubMed:12609849). Also activates transcription of SOX3 in complex with MEIS1 by binding to the 5'-TGATTGAC-3' consensus sequence (By similarity). In natural killer cells, binds to the NFIL3 promoter and acts as a transcriptional activator of NFIL3, promoting natural killer cell development (By similarity). Plays a role in the cAMP-dependent regulation of CYP17A1 gene expression via its cAMP-regulatory sequence (CRS1) (By similarity). Probably in complex with MEIS2, involved in transcriptional regulation by KLF4 (PubMed:21746878). Acts as a transcriptional activator of NKX2-5 and a transcriptional repressor of CDKN2B (By similarity). Together with NKX2-5, required for spleen development through a mechanism that involves CDKN2B repression (By similarity). {ECO:0000250|UniProtKB:P41778, ECO:0000269|PubMed:12609849, ECO:0000269|PubMed:21746878, ECO:0000269|PubMed:7791786, ECO:0000269|PubMed:8327485, ECO:0000269|PubMed:9191052}.; FUNCTION: [Isoform PBX1b]: As part of a PDX1:PBX1b:MEIS2B complex in pancreatic acinar cells, is involved in the transcriptional activation of the ELA1 enhancer; the complex binds to the enhancer B element and cooperates with the transcription factor 1 complex (PTF1) bound to the enhancer A element. {ECO:0000250|UniProtKB:P41778}.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneRFWD2chr1:164532548chr1:175958615ENST000003087691319553_593552.3333333333334708.0RepeatNote=WD 4
TgeneRFWD2chr1:164532548chr1:175958615ENST000003087691319597_635552.3333333333334708.0RepeatNote=WD 5
TgeneRFWD2chr1:164532548chr1:175958615ENST000003087691319638_677552.3333333333334708.0RepeatNote=WD 6
TgeneRFWD2chr1:164532548chr1:175958615ENST000003087691319691_729552.3333333333334708.0RepeatNote=WD 7
TgeneRFWD2chr1:164532548chr1:175958615ENST000003676691420597_635576.3333333333334732.0RepeatNote=WD 5
TgeneRFWD2chr1:164532548chr1:175958615ENST000003676691420638_677576.3333333333334732.0RepeatNote=WD 6
TgeneRFWD2chr1:164532548chr1:175958615ENST000003676691420691_729576.3333333333334732.0RepeatNote=WD 7

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePBX1chr1:164532548chr1:175958615ENST00000367897+28127_13588.33333333333333408.3333333333333Compositional biasNote=Poly-Ala
HgenePBX1chr1:164532548chr1:175958615ENST00000401534+27127_13588.33333333333333348.0Compositional biasNote=Poly-Ala
HgenePBX1chr1:164532548chr1:175958615ENST00000420696+29127_13588.33333333333333431.0Compositional biasNote=Poly-Ala
HgenePBX1chr1:164532548chr1:175958615ENST00000540236+29127_13588.33333333333333421.0Compositional biasNote=Poly-Ala
HgenePBX1chr1:164532548chr1:175958615ENST00000367897+28233_29588.33333333333333408.3333333333333DNA bindingHomeobox%3B TALE-type
HgenePBX1chr1:164532548chr1:175958615ENST00000401534+27233_29588.33333333333333348.0DNA bindingHomeobox%3B TALE-type
HgenePBX1chr1:164532548chr1:175958615ENST00000420696+29233_29588.33333333333333431.0DNA bindingHomeobox%3B TALE-type
HgenePBX1chr1:164532548chr1:175958615ENST00000540236+29233_29588.33333333333333421.0DNA bindingHomeobox%3B TALE-type
HgenePBX1chr1:164532548chr1:175958615ENST00000367897+2840_23288.33333333333333408.3333333333333DomainPBC
HgenePBX1chr1:164532548chr1:175958615ENST00000401534+2740_23288.33333333333333348.0DomainPBC
HgenePBX1chr1:164532548chr1:175958615ENST00000420696+2940_23288.33333333333333431.0DomainPBC
HgenePBX1chr1:164532548chr1:175958615ENST00000540236+2940_23288.33333333333333421.0DomainPBC
TgeneRFWD2chr1:164532548chr1:175958615ENST000003087691319233_301552.3333333333334708.0Coiled coilOntology_term=ECO:0000255
TgeneRFWD2chr1:164532548chr1:175958615ENST000003676691420233_301576.3333333333334732.0Coiled coilOntology_term=ECO:0000255
TgeneRFWD2chr1:164532548chr1:175958615ENST0000030876913192_110552.3333333333334708.0Compositional biasNote=Ser-rich
TgeneRFWD2chr1:164532548chr1:175958615ENST0000036766914202_110576.3333333333334732.0Compositional biasNote=Ser-rich
TgeneRFWD2chr1:164532548chr1:175958615ENST000003087691319109_113552.3333333333334708.0MotifNote=Nuclear localization signal 1
TgeneRFWD2chr1:164532548chr1:175958615ENST000003087691319195_206552.3333333333334708.0MotifNote=Nuclear localization signal 2
TgeneRFWD2chr1:164532548chr1:175958615ENST000003087691319235_245552.3333333333334708.0MotifNuclear export signal
TgeneRFWD2chr1:164532548chr1:175958615ENST000003676691420109_113576.3333333333334732.0MotifNote=Nuclear localization signal 1
TgeneRFWD2chr1:164532548chr1:175958615ENST000003676691420195_206576.3333333333334732.0MotifNote=Nuclear localization signal 2
TgeneRFWD2chr1:164532548chr1:175958615ENST000003676691420235_245576.3333333333334732.0MotifNuclear export signal
TgeneRFWD2chr1:164532548chr1:175958615ENST000003087691319419_458552.3333333333334708.0RepeatNote=WD 1
TgeneRFWD2chr1:164532548chr1:175958615ENST000003087691319468_508552.3333333333334708.0RepeatNote=WD 2
TgeneRFWD2chr1:164532548chr1:175958615ENST000003087691319511_551552.3333333333334708.0RepeatNote=WD 3
TgeneRFWD2chr1:164532548chr1:175958615ENST000003676691420419_458576.3333333333334732.0RepeatNote=WD 1
TgeneRFWD2chr1:164532548chr1:175958615ENST000003676691420468_508576.3333333333334732.0RepeatNote=WD 2
TgeneRFWD2chr1:164532548chr1:175958615ENST000003676691420511_551576.3333333333334732.0RepeatNote=WD 3
TgeneRFWD2chr1:164532548chr1:175958615ENST000003676691420553_593576.3333333333334732.0RepeatNote=WD 4
TgeneRFWD2chr1:164532548chr1:175958615ENST000003087691319136_174552.3333333333334708.0Zinc fingerRING-type
TgeneRFWD2chr1:164532548chr1:175958615ENST000003676691420136_174576.3333333333334732.0Zinc fingerRING-type


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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
PBX1all structure
RFWD2


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to PBX1-RFWD2


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to PBX1-RFWD2


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgenePBX1C0006413Burkitt Lymphoma2CTD_human;ORPHANET
HgenePBX1C0343640African Burkitt's lymphoma2CTD_human
HgenePBX1C1968949Cakut2GENOMICS_ENGLAND
HgenePBX1C4721444Burkitt Leukemia2CTD_human
HgenePBX1C0013146Drug abuse1CTD_human
HgenePBX1C0013170Drug habituation1CTD_human
HgenePBX1C0013222Drug Use Disorders1CTD_human
HgenePBX1C0029231Organic Mental Disorders, Substance-Induced1CTD_human
HgenePBX1C0038580Substance Dependence1CTD_human
HgenePBX1C0038586Substance Use Disorders1CTD_human
HgenePBX1C0236969Substance-Related Disorders1CTD_human
HgenePBX1C0431692Bilateral renal hypoplasia1ORPHANET
HgenePBX1C0740858Substance abuse problem1CTD_human
HgenePBX1C1510472Drug Dependence1CTD_human
HgenePBX1C4316881Prescription Drug Abuse1CTD_human
HgenePBX1C4539968CONGENITAL ANOMALIES OF KIDNEY AND URINARY TRACT SYNDROME WITH OR WITHOUT HEARING LOSS, ABNORMAL EARS, OR DEVELOPMENTAL DELAY1GENOMICS_ENGLAND