UTHEALTH HOME ABOUT SBMI A-Z WEBMAIL INSIDE THE UNIVERSITY

Home

Download

Statistics

Examples

Help

Contact

level1

	Fusion Gene Summary
	Fusion Gene Sample Information
	Fusion ORF Analysis
	Fusion Amino Acid Sequences
	Fusion Protein Functional Features
	Fusion Protein-Protein Interaction
	Related drugs with this fusion protein
	Related disease with this fusion protein

Fusion Protein:PCYOX1-CEL

Fusion Protein Summary

Fusion gene summary

Fusion partner gene information	Fusion gene name: PCYOX1-CEL
	FusionPDB ID: 63548
	FusionGDB2.0 ID: 63548
		Hgene	Tgene
	Gene symbol	PCYOX1	CEL
	Gene ID	51449	1056
	Gene name	prenylcysteine oxidase 1	carboxyl ester lipase
	Synonyms	PCL1	BAL\|BSDL\|BSSL\|CELL\|CEase\|FAP\|FAPP\|LIPA\|MODY8
	Cytomap	2p13.3	9q34.13
	Type of gene	protein-coding	protein-coding
	Description	prenylcysteine oxidase 1prenylcysteine lyase	bile salt-activated lipasebile salt-dependent lipase, oncofetal isoformbucelipasecarboxyl ester hydrolasecarboxyl ester lipase (bile salt-stimulated lipase)cholesterol esterasefetoacinar pancreatic proteinlysophospholipase, pancreaticsterol estera
	Modification date	20200313	20200313
	UniProtAcc	.	Q9NYQ7
Ensembl transtripts involved in fusion gene	ENST ids	ENST00000264441, ENST00000433351, ENST00000505044, ENST00000545138,	ENST00000351304, ENST00000372080,
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)	* DoF score	4 X 3 X 2=24	5 X 6 X 4=120
	# samples	4	6
	** MAII score	log2(4/24*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0	log2(6/120*10)=-1 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)	PubMed: PCYOX1 [Title/Abstract] AND CEL [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)	PCYOX1(70488361)-CEL(135937365), # samples:1
Anticipated loss of major functional domain due to fusion event.	PCYOX1-CEL seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. PCYOX1-CEL seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	PCYOX1	GO:0030327	prenylated protein catabolic process	10585463
Tgene	CEL	GO:0006707	cholesterol catabolic process	12031288
Tgene	CEL	GO:0030157	pancreatic juice secretion	1854805

Fusion gene breakpoints across PCYOX1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across CEL (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Top

Fusion Gene Sample Information

Fusion gene information from FusionGDB2.0.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChiTaRS5.0	N/A	M54994	PCYOX1	chr2	70488361	-	CEL	chr9	135937365	+

Top

Fusion ORF Analysis

Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000505044	PCYOX1	chr2	70488361	-	ENST00000351304	CEL	chr9	135937365	+	2776	590	216	2678	820
ENST00000505044	PCYOX1	chr2	70488361	-	ENST00000372080	CEL	chr9	135937365	+	2974	590	216	2876	886
ENST00000433351	PCYOX1	chr2	70488361	-	ENST00000351304	CEL	chr9	135937365	+	2690	504	28	2592	854
ENST00000433351	PCYOX1	chr2	70488361	-	ENST00000372080	CEL	chr9	135937365	+	2888	504	28	2790	920
ENST00000264441	PCYOX1	chr2	70488361	-	ENST00000351304	CEL	chr9	135937365	+	2678	492	16	2580	854
ENST00000264441	PCYOX1	chr2	70488361	-	ENST00000372080	CEL	chr9	135937365	+	2876	492	16	2778	920
ENST00000545138	PCYOX1	chr2	70488361	-	ENST00000351304	CEL	chr9	135937365	+	2616	430	110	2518	802
ENST00000545138	PCYOX1	chr2	70488361	-	ENST00000372080	CEL	chr9	135937365	+	2814	430	110	2716	868

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000505044	ENST00000351304	PCYOX1	chr2	70488361	-	CEL	chr9	135937365	+	0.003507279	0.9964927
ENST00000505044	ENST00000372080	PCYOX1	chr2	70488361	-	CEL	chr9	135937365	+	0.002602306	0.99739766
ENST00000433351	ENST00000351304	PCYOX1	chr2	70488361	-	CEL	chr9	135937365	+	0.00147668	0.9985233
ENST00000433351	ENST00000372080	PCYOX1	chr2	70488361	-	CEL	chr9	135937365	+	0.000945164	0.99905485
ENST00000264441	ENST00000351304	PCYOX1	chr2	70488361	-	CEL	chr9	135937365	+	0.00136517	0.99863476
ENST00000264441	ENST00000372080	PCYOX1	chr2	70488361	-	CEL	chr9	135937365	+	0.000892443	0.99910754
ENST00000545138	ENST00000351304	PCYOX1	chr2	70488361	-	CEL	chr9	135937365	+	0.003104525	0.99689543
ENST00000545138	ENST00000372080	PCYOX1	chr2	70488361	-	CEL	chr9	135937365	+	0.002289538	0.99771047

Top

Fusion Amino Acid Sequences

For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>63548_63548_1_PCYOX1-CEL_PCYOX1_chr2_70488361_ENST00000264441_CEL_chr9_135937365_ENST00000351304_length(amino acids)=854AA_BP=158
MGRVVAELVSSLLGLWLLLCSCGCPEGAELRAPPDKIAIIGAGIGGTSAAYYLRQKFGKDVKIDLFEREEVGGRLATMMVQGQEYEAGGS
VIHPLNLHMKRFVKDLASGGLLGIYNGETLVFEESNWFIINVIKLVWRYGFQSLRMHMWVEDVLDKFMRATQRLMLTMGRLQLVVLGLTC
CWAVASAAKLGAVYTEGGFVEGVNKKLGLLGDSVDIFKGIPFAAPTKALENPQPHPGWQGTLKAKNFKKRCLQATITQDSTYGDEDCLYL
NIWVPQGRKQVSRDLPVMIWIYGGAFLMGSGHGANFLNNYLYDGEEIATRGNVIVVTFNYRVGPLGFLSTGDANLPGNYGLRDQHMAIAW
VKRNIAAFGGDPNNITLFGESAGGASVSLQTLSPYNKGLIRRAISQSGVALSPWVIQKNPLFWAKKVAEKVGCPVGDAARMAQCLKVTDP
RALTLAYKVPLAGLEYPMLHYVGFVPVIDGDFIPADPINLYANAADIDYIAGTNNMDGHIFASIDMPAINKGNKKVTEEDFYKLVSEFTI
TKGLRGAKTTFDVYTESWAQDPSQENKKKTVVDFETDVLFLVPTEIALAQHRANAKDPNMGDSAVPTHWEPYTTENSGYLEITKKMGSSS
MKRSLRTNFLRYWTLTYLALPTVTDQEATPVPPTGDSEATPVPPTGDSETAPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTG
DSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDAGPPPVPPTGDSGAPPVPPTGDSGAPPVTPTGDS

--------------------------------------------------------------

>63548_63548_2_PCYOX1-CEL_PCYOX1_chr2_70488361_ENST00000264441_CEL_chr9_135937365_ENST00000372080_length(amino acids)=920AA_BP=158
MGRVVAELVSSLLGLWLLLCSCGCPEGAELRAPPDKIAIIGAGIGGTSAAYYLRQKFGKDVKIDLFEREEVGGRLATMMVQGQEYEAGGS
VIHPLNLHMKRFVKDLASGGLLGIYNGETLVFEESNWFIINVIKLVWRYGFQSLRMHMWVEDVLDKFMRATQRLMLTMGRLQLVVLGLTC
CWAVASAAKLGAVYTEGGFVEGVNKKLGLLGDSVDIFKGIPFAAPTKALENPQPHPGWQGTLKAKNFKKRCLQATITQDSTYGDEDCLYL
NIWVPQGRKQVSRDLPVMIWIYGGAFLMGSGHGANFLNNYLYDGEEIATRGNVIVVTFNYRVGPLGFLSTGDANLPGNYGLRDQHMAIAW
VKRNIAAFGGDPNNITLFGESAGGASVSLQTLSPYNKGLIRRAISQSGVALSPWVIQKNPLFWAKKVAEKVGCPVGDAARMAQCLKVTDP
RALTLAYKVPLAGLEYPMLHYVGFVPVIDGDFIPADPINLYANAADIDYIAGTNNMDGHIFASIDMPAINKGNKKVTEEDFYKLVSEFTI
TKGLRGAKTTFDVYTESWAQDPSQENKKKTVVDFETDVLFLVPTEIALAQHRANAKSAKTYAYLFSHPSRMPVYPKWVGADHADDIQYVF
GKPFATPTGYRPQDRTVSKAMIAYWTNFAKTGDPNMGDSAVPTHWEPYTTENSGYLEITKKMGSSSMKRSLRTNFLRYWTLTYLALPTVT
DQEATPVPPTGDSEATPVPPTGDSETAPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDS
GAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDAGPPPVPPTGDSGAPPVPPTGDSGAPPVTPTGDSETAPVPPTGDSGAPPVPPTGDSEA

--------------------------------------------------------------

>63548_63548_3_PCYOX1-CEL_PCYOX1_chr2_70488361_ENST00000433351_CEL_chr9_135937365_ENST00000351304_length(amino acids)=854AA_BP=158
MGRVVAELVSSLLGLWLLLCSCGCPEGAELRAPPDKIAIIGAGIGGTSAAYYLRQKFGKDVKIDLFEREEVGGRLATMMVQGQEYEAGGS
VIHPLNLHMKRFVKDLASGGLLGIYNGETLVFEESNWFIINVIKLVWRYGFQSLRMHMWVEDVLDKFMRATQRLMLTMGRLQLVVLGLTC
CWAVASAAKLGAVYTEGGFVEGVNKKLGLLGDSVDIFKGIPFAAPTKALENPQPHPGWQGTLKAKNFKKRCLQATITQDSTYGDEDCLYL
NIWVPQGRKQVSRDLPVMIWIYGGAFLMGSGHGANFLNNYLYDGEEIATRGNVIVVTFNYRVGPLGFLSTGDANLPGNYGLRDQHMAIAW
VKRNIAAFGGDPNNITLFGESAGGASVSLQTLSPYNKGLIRRAISQSGVALSPWVIQKNPLFWAKKVAEKVGCPVGDAARMAQCLKVTDP
RALTLAYKVPLAGLEYPMLHYVGFVPVIDGDFIPADPINLYANAADIDYIAGTNNMDGHIFASIDMPAINKGNKKVTEEDFYKLVSEFTI
TKGLRGAKTTFDVYTESWAQDPSQENKKKTVVDFETDVLFLVPTEIALAQHRANAKDPNMGDSAVPTHWEPYTTENSGYLEITKKMGSSS
MKRSLRTNFLRYWTLTYLALPTVTDQEATPVPPTGDSEATPVPPTGDSETAPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTG
DSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDAGPPPVPPTGDSGAPPVPPTGDSGAPPVTPTGDS

--------------------------------------------------------------

>63548_63548_4_PCYOX1-CEL_PCYOX1_chr2_70488361_ENST00000433351_CEL_chr9_135937365_ENST00000372080_length(amino acids)=920AA_BP=158
MGRVVAELVSSLLGLWLLLCSCGCPEGAELRAPPDKIAIIGAGIGGTSAAYYLRQKFGKDVKIDLFEREEVGGRLATMMVQGQEYEAGGS
VIHPLNLHMKRFVKDLASGGLLGIYNGETLVFEESNWFIINVIKLVWRYGFQSLRMHMWVEDVLDKFMRATQRLMLTMGRLQLVVLGLTC
CWAVASAAKLGAVYTEGGFVEGVNKKLGLLGDSVDIFKGIPFAAPTKALENPQPHPGWQGTLKAKNFKKRCLQATITQDSTYGDEDCLYL
NIWVPQGRKQVSRDLPVMIWIYGGAFLMGSGHGANFLNNYLYDGEEIATRGNVIVVTFNYRVGPLGFLSTGDANLPGNYGLRDQHMAIAW
VKRNIAAFGGDPNNITLFGESAGGASVSLQTLSPYNKGLIRRAISQSGVALSPWVIQKNPLFWAKKVAEKVGCPVGDAARMAQCLKVTDP
RALTLAYKVPLAGLEYPMLHYVGFVPVIDGDFIPADPINLYANAADIDYIAGTNNMDGHIFASIDMPAINKGNKKVTEEDFYKLVSEFTI
TKGLRGAKTTFDVYTESWAQDPSQENKKKTVVDFETDVLFLVPTEIALAQHRANAKSAKTYAYLFSHPSRMPVYPKWVGADHADDIQYVF
GKPFATPTGYRPQDRTVSKAMIAYWTNFAKTGDPNMGDSAVPTHWEPYTTENSGYLEITKKMGSSSMKRSLRTNFLRYWTLTYLALPTVT
DQEATPVPPTGDSEATPVPPTGDSETAPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDS
GAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDAGPPPVPPTGDSGAPPVPPTGDSGAPPVTPTGDSETAPVPPTGDSGAPPVPPTGDSEA

--------------------------------------------------------------

>63548_63548_5_PCYOX1-CEL_PCYOX1_chr2_70488361_ENST00000505044_CEL_chr9_135937365_ENST00000351304_length(amino acids)=820AA_BP=124
MKEAIIGAGIGGTSAAYYLRQKFGKDVKIDLFEREEVGGRLATMMVQGQEYEAGGSVIHPLNLHMKRFVKDLASGGLLGIYNGETLVFEE
SNWFIINVIKLVWRYGFQSLRMHMWVEDVLDKFMRATQRLMLTMGRLQLVVLGLTCCWAVASAAKLGAVYTEGGFVEGVNKKLGLLGDSV
DIFKGIPFAAPTKALENPQPHPGWQGTLKAKNFKKRCLQATITQDSTYGDEDCLYLNIWVPQGRKQVSRDLPVMIWIYGGAFLMGSGHGA
NFLNNYLYDGEEIATRGNVIVVTFNYRVGPLGFLSTGDANLPGNYGLRDQHMAIAWVKRNIAAFGGDPNNITLFGESAGGASVSLQTLSP
YNKGLIRRAISQSGVALSPWVIQKNPLFWAKKVAEKVGCPVGDAARMAQCLKVTDPRALTLAYKVPLAGLEYPMLHYVGFVPVIDGDFIP
ADPINLYANAADIDYIAGTNNMDGHIFASIDMPAINKGNKKVTEEDFYKLVSEFTITKGLRGAKTTFDVYTESWAQDPSQENKKKTVVDF
ETDVLFLVPTEIALAQHRANAKDPNMGDSAVPTHWEPYTTENSGYLEITKKMGSSSMKRSLRTNFLRYWTLTYLALPTVTDQEATPVPPT
GDSEATPVPPTGDSETAPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGD
SGAPPVPPTGDSGAPPVPPTGDAGPPPVPPTGDSGAPPVPPTGDSGAPPVTPTGDSETAPVPPTGDSGAPPVPPTGDSEAAPVPPTDDSK

--------------------------------------------------------------

>63548_63548_6_PCYOX1-CEL_PCYOX1_chr2_70488361_ENST00000505044_CEL_chr9_135937365_ENST00000372080_length(amino acids)=886AA_BP=124
MKEAIIGAGIGGTSAAYYLRQKFGKDVKIDLFEREEVGGRLATMMVQGQEYEAGGSVIHPLNLHMKRFVKDLASGGLLGIYNGETLVFEE
SNWFIINVIKLVWRYGFQSLRMHMWVEDVLDKFMRATQRLMLTMGRLQLVVLGLTCCWAVASAAKLGAVYTEGGFVEGVNKKLGLLGDSV
DIFKGIPFAAPTKALENPQPHPGWQGTLKAKNFKKRCLQATITQDSTYGDEDCLYLNIWVPQGRKQVSRDLPVMIWIYGGAFLMGSGHGA
NFLNNYLYDGEEIATRGNVIVVTFNYRVGPLGFLSTGDANLPGNYGLRDQHMAIAWVKRNIAAFGGDPNNITLFGESAGGASVSLQTLSP
YNKGLIRRAISQSGVALSPWVIQKNPLFWAKKVAEKVGCPVGDAARMAQCLKVTDPRALTLAYKVPLAGLEYPMLHYVGFVPVIDGDFIP
ADPINLYANAADIDYIAGTNNMDGHIFASIDMPAINKGNKKVTEEDFYKLVSEFTITKGLRGAKTTFDVYTESWAQDPSQENKKKTVVDF
ETDVLFLVPTEIALAQHRANAKSAKTYAYLFSHPSRMPVYPKWVGADHADDIQYVFGKPFATPTGYRPQDRTVSKAMIAYWTNFAKTGDP
NMGDSAVPTHWEPYTTENSGYLEITKKMGSSSMKRSLRTNFLRYWTLTYLALPTVTDQEATPVPPTGDSEATPVPPTGDSETAPVPPTGD
SGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDAG

--------------------------------------------------------------

>63548_63548_7_PCYOX1-CEL_PCYOX1_chr2_70488361_ENST00000545138_CEL_chr9_135937365_ENST00000351304_length(amino acids)=802AA_BP=106
MRQKFGKDVKIDLFEREEVGGRLATMMVQGQEYEAGGSVIHPLNLHMKRFVKDLASGGLLGIYNGETLVFEESNWFIINVIKLVWRYGFQ
SLRMHMWVEDVLDKFMRATQRLMLTMGRLQLVVLGLTCCWAVASAAKLGAVYTEGGFVEGVNKKLGLLGDSVDIFKGIPFAAPTKALENP
QPHPGWQGTLKAKNFKKRCLQATITQDSTYGDEDCLYLNIWVPQGRKQVSRDLPVMIWIYGGAFLMGSGHGANFLNNYLYDGEEIATRGN
VIVVTFNYRVGPLGFLSTGDANLPGNYGLRDQHMAIAWVKRNIAAFGGDPNNITLFGESAGGASVSLQTLSPYNKGLIRRAISQSGVALS
PWVIQKNPLFWAKKVAEKVGCPVGDAARMAQCLKVTDPRALTLAYKVPLAGLEYPMLHYVGFVPVIDGDFIPADPINLYANAADIDYIAG
TNNMDGHIFASIDMPAINKGNKKVTEEDFYKLVSEFTITKGLRGAKTTFDVYTESWAQDPSQENKKKTVVDFETDVLFLVPTEIALAQHR
ANAKDPNMGDSAVPTHWEPYTTENSGYLEITKKMGSSSMKRSLRTNFLRYWTLTYLALPTVTDQEATPVPPTGDSEATPVPPTGDSETAP
VPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVP

--------------------------------------------------------------

>63548_63548_8_PCYOX1-CEL_PCYOX1_chr2_70488361_ENST00000545138_CEL_chr9_135937365_ENST00000372080_length(amino acids)=868AA_BP=106
MRQKFGKDVKIDLFEREEVGGRLATMMVQGQEYEAGGSVIHPLNLHMKRFVKDLASGGLLGIYNGETLVFEESNWFIINVIKLVWRYGFQ
SLRMHMWVEDVLDKFMRATQRLMLTMGRLQLVVLGLTCCWAVASAAKLGAVYTEGGFVEGVNKKLGLLGDSVDIFKGIPFAAPTKALENP
QPHPGWQGTLKAKNFKKRCLQATITQDSTYGDEDCLYLNIWVPQGRKQVSRDLPVMIWIYGGAFLMGSGHGANFLNNYLYDGEEIATRGN
VIVVTFNYRVGPLGFLSTGDANLPGNYGLRDQHMAIAWVKRNIAAFGGDPNNITLFGESAGGASVSLQTLSPYNKGLIRRAISQSGVALS
PWVIQKNPLFWAKKVAEKVGCPVGDAARMAQCLKVTDPRALTLAYKVPLAGLEYPMLHYVGFVPVIDGDFIPADPINLYANAADIDYIAG
TNNMDGHIFASIDMPAINKGNKKVTEEDFYKLVSEFTITKGLRGAKTTFDVYTESWAQDPSQENKKKTVVDFETDVLFLVPTEIALAQHR
ANAKSAKTYAYLFSHPSRMPVYPKWVGADHADDIQYVFGKPFATPTGYRPQDRTVSKAMIAYWTNFAKTGDPNMGDSAVPTHWEPYTTEN
SGYLEITKKMGSSSMKRSLRTNFLRYWTLTYLALPTVTDQEATPVPPTGDSEATPVPPTGDSETAPVPPTGDSGAPPVPPTGDSGAPPVP
PTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDAGPPPVPPTGDSGAPPVPPT

--------------------------------------------------------------

Top

Fusion Protein Functional Features

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr2:70488361/chr9:135937365)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	CEL Q9NYQ7
FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.	FUNCTION: Receptor that may have an important role in cell/cell signaling during nervous system formation.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
* Minus value of BPloci means that the break pointn is located before the CDS.

- Retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

CEL

chr2:70488361

chr9:135937365

ENST00000351304

-1

21_121

22.0

688.0

Region

Note=Heparin-binding

Tgene

CEL

chr2:70488361

chr9:135937365

ENST00000351304

-1

559_745

22.0

688.0

Region

Note=17 X 11 AA tandem repeats%2C glycodomain%2C O-linked (mucin type)

Tgene

CEL

chr2:70488361

chr9:135937365

ENST00000351304

-1

559_569

22.0

688.0

Repeat

Note=1

Tgene

CEL

chr2:70488361

chr9:135937365

ENST00000351304

-1

570_580

22.0

688.0

Repeat

Note=2

Tgene

CEL

chr2:70488361

chr9:135937365

ENST00000351304

-1

581_591

22.0

688.0

Repeat

Note=3

Tgene

CEL

chr2:70488361

chr9:135937365

ENST00000351304

-1

592_602

22.0

688.0

Repeat

Note=4

Tgene

CEL

chr2:70488361

chr9:135937365

ENST00000351304

-1

603_613

22.0

688.0

Repeat

Note=5

Tgene

CEL

chr2:70488361

chr9:135937365

ENST00000351304

-1

614_624

22.0

688.0

Repeat

Note=6

Tgene

CEL

chr2:70488361

chr9:135937365

ENST00000351304

-1

625_635

22.0

688.0

Repeat

Note=7

Tgene

CEL

chr2:70488361

chr9:135937365

ENST00000351304

-1

636_646

22.0

688.0

Repeat

Note=8

Tgene

CEL

chr2:70488361

chr9:135937365

ENST00000351304

-1

647_657

22.0

688.0

Repeat

Note=9

Tgene

CEL

chr2:70488361

chr9:135937365

ENST00000351304

-1

658_668

22.0

688.0

Repeat

Note=10

Tgene

CEL

chr2:70488361

chr9:135937365

ENST00000351304

-1

669_679

22.0

688.0

Repeat

Note=11

Tgene

CEL

chr2:70488361

chr9:135937365

ENST00000351304

-1

680_690

22.0

688.0

Repeat

Note=12

Tgene

CEL

chr2:70488361

chr9:135937365

ENST00000351304

-1

691_701

22.0

688.0

Repeat

Note=13

Tgene

CEL

chr2:70488361

chr9:135937365

ENST00000351304

-1

702_712

22.0

688.0

Repeat

Note=14

Tgene

CEL

chr2:70488361

chr9:135937365

ENST00000351304

-1

713_723

22.0

688.0

Repeat

Note=15

Tgene

CEL

chr2:70488361

chr9:135937365

ENST00000351304

-1

724_734

22.0

688.0

Repeat

Note=16

Tgene

CEL

chr2:70488361

chr9:135937365

ENST00000351304

-1

735_745

22.0

688.0

Repeat

Note=17

- Not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Top

Fusion Protein-Protein Interaction

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)

Gene

PPI interactors

Protein-protein interactors based on sequence similarity (STRING)

Gene	STRING network
PCYOX1
CEL

- Retained interactions in fusion protein (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost interactions due to fusion (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs to PCYOX1-CEL

Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Drug

Source

PMID

Top

Related Diseases to PCYOX1-CEL

Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Disease

Source

PMID

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source