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Center for Computational Systems Medicine level1
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:ARID1B-NKAIN2

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: ARID1B-NKAIN2
FusionPDB ID: 6409
FusionGDB2.0 ID: 6409
HgeneTgene
Gene symbol

ARID1B

NKAIN2

Gene ID

57492

154215

Gene nameAT-rich interaction domain 1Bsodium/potassium transporting ATPase interacting 2
Synonyms6A3-5|BAF250B|BRIGHT|CSS1|DAN15|ELD/OSA1|MRD12|OSA2|P250RFAM77B|NKAIP2|TCBA|TCBA1
Cytomap

6q25.3

6q22.31

Type of geneprotein-codingprotein-coding
DescriptionAT-rich interactive domain-containing protein 1BARID domain-containing protein 1BAT rich interactive domain 1B (SWI1-like)BRG1-associated factor 250bBRG1-binding protein ELD/OSA1ELD (eyelid)/OSA proteinsodium/potassium-transporting ATPase subunit beta-1-interacting protein 2Na(+)/K(+)-transporting ATPase subunit beta-1-interacting protein 2Na+/K+ transporting ATPase interacting 2T-cell lymphoma breakpoint-associated target protein 1
Modification date2020032020200313
UniProtAcc

Q8NFD5

Q5VXU1

Ensembl transtripts involved in fusion geneENST idsENST00000275248, ENST00000346085, 
ENST00000350026, ENST00000367148, 
ENST00000478761, 		ENST00000476571, 
ENST00000545433, ENST00000546092, 
ENST00000368416, ENST00000368417, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score27 X 18 X 14=680414 X 12 X 7=1176
# samples 3118
** MAII scorelog2(31/6804*10)=-4.45604302038915
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(18/1176*10)=-2.70781924850669
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: ARID1B [Title/Abstract] AND NKAIN2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)ARID1B(157256710)-NKAIN2(124979332), # samples:2
Anticipated loss of major functional domain due to fusion event.ARID1B-NKAIN2 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ARID1B-NKAIN2 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ARID1B-NKAIN2 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
ARID1B-NKAIN2 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
ARID1B-NKAIN2 seems lost the major protein functional domain in Hgene partner, which is a CGC due to the frame-shifted ORF.
ARID1B-NKAIN2 seems lost the major protein functional domain in Hgene partner, which is a epigenetic factor due to the frame-shifted ORF.
ARID1B-NKAIN2 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across ARID1B (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across NKAIN2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-E2-A1LK-01AARID1Bchr6

157256710

+NKAIN2chr6

124979332

+


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000350026ARID1Bchr6157256710+ENST00000368417NKAIN2chr6124979332+4781199912352783
ENST00000346085ARID1Bchr6157256710+ENST00000368417NKAIN2chr6124979332+4820203812391796
ENST00000367148ARID1Bchr6157256710+ENST00000368417NKAIN2chr6124979332+4780199802351783
ENST00000275248ARID1Bchr6157256710+ENST00000368417NKAIN2chr6124979332+47581976772329750

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000350026ENST00000368417ARID1Bchr6157256710+NKAIN2chr6124979332+0.0082281260.9917719
ENST00000346085ENST00000368417ARID1Bchr6157256710+NKAIN2chr6124979332+0.0077645030.9922355
ENST00000367148ENST00000368417ARID1Bchr6157256710+NKAIN2chr6124979332+0.008228670.9917713
ENST00000275248ENST00000368417ARID1Bchr6157256710+NKAIN2chr6124979332+0.0091927040.99080735

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>6409_6409_1_ARID1B-NKAIN2_ARID1B_chr6_157256710_ENST00000275248_NKAIN2_chr6_124979332_ENST00000368417_length(amino acids)=750AA_BP=631
MSSSSSSSAAAAAASSSSSSGPGSAMETGLLPNHKLKTVGEAPAAPPHQQHHHHHHAHHHHHHAHHLHHHHALQQQLNQFQQQQQQQQQQ
QQQQQQQQHPISNNNSLGGAGGGAPQPGPDMEQPQHGGAKDSAAGGQADPPGPPLLSKPGDEDDAPPKMGEPAGGRYEHPGLGALGTQQP
PVAVPGGGGGPAAVPEFNNYYGSAAPASGGPGGRAGPCFDQHGGQQSPGMGMMHSASAAAAGAPGSMDPLQNSHEGYPNSQCNHYPGYSR
PGAGGGGGGGGGGGGGSGGGGGGGGAGAGGAGAGAVAAAAAAAAAAAGGGGGGGYGGSSAGYGVLSSPRQQGGGMMMGPGGGGAASLSKA
AAGSAAGGFQRFAGQNQHPSGATPTLNQLLTSPSPMMRSYGGSYPEYSSPSAPPPPPSQPQSQAAAAGAAAGGQQAAAGMGLGKDMGAQY
AAASPAWAAAQQRSHPAMSPGTPGPTMGRSQGSPMDPMVMKRPQLYGMGSNPHSQPQQSSPYPGGSYGPPGPQRYPIGIQGRTPGAMAGM
QYPQQQMPPQYGQQGVSGYCQQGQQPYYSQQPQPPHLPPQAQYLPSQSQQRYQPQQDMSQEGYGTRSQPPLAPGKPNHEDLNLIQQERPS
SLPETDLILTFNISMHRSWWMENGPGCTVTSVTPAPDWAPEDHRYITVSGCLLEYQYIEVAHSSLQIVLALAGFIYACYVVKCITEEEDS

--------------------------------------------------------------

>6409_6409_2_ARID1B-NKAIN2_ARID1B_chr6_157256710_ENST00000346085_NKAIN2_chr6_124979332_ENST00000368417_length(amino acids)=796AA_BP=677
MAHNAGAAAAAGTHSAKSGGSEAALKEGGSAAALSSSSSSSAAAAAASSSSSSGPGSAMETGLLPNHKLKTVGEAPAAPPHQQHHHHHHA
HHHHHHAHHLHHHHALQQQLNQFQQQQQQQQQQQQQQQQQQHPISNNNSLGGAGGGAPQPGPDMEQPQHGGAKDSAAGGQADPPGPPLLS
KPGDEDDAPPKMGEPAGGRYEHPGLGALGTQQPPVAVPGGGGGPAAVPEFNNYYGSAAPASGGPGGRAGPCFDQHGGQQSPGMGMMHSAS
AAAAGAPGSMDPLQNSHEGYPNSQCNHYPGYSRPGAGGGGGGGGGGGGGSGGGGGGGGAGAGGAGAGAVAAAAAAAAAAAGGGGGGGYGG
SSAGYGVLSSPRQQGGGMMMGPGGGGAASLSKAAAGSAAGGFQRFAGQNQHPSGATPTLNQLLTSPSPMMRSYGGSYPEYSSPSAPPPPP
SQPQSQAAAAGAAAGGQQAAAGMGLGKDMGAQYAAASPAWAAAQQRSHPAMSPGTPGPTMGRSQGSPMDPMVMKRPQLYGMGSNPHSQPQ
QSSPYPGGSYGPPGPQRYPIGIQGRTPGAMAGMQYPQQQDSGDATWKETFWLMPPQYGQQGVSGYCQQGQQPYYSQQPQPPHLPPQAQYL
PSQSQQRYQPQQDMSQEGYGTRSQPPLAPGKPNHEDLNLIQQERPSSLPETDLILTFNISMHRSWWMENGPGCTVTSVTPAPDWAPEDHR

--------------------------------------------------------------

>6409_6409_3_ARID1B-NKAIN2_ARID1B_chr6_157256710_ENST00000350026_NKAIN2_chr6_124979332_ENST00000368417_length(amino acids)=783AA_BP=664
MAHNAGAAAAAGTHSAKSGGSEAALKEGGSAAALSSSSSSSAAAAAASSSSSSGPGSAMETGLLPNHKLKTVGEAPAAPPHQQHHHHHHA
HHHHHHAHHLHHHHALQQQLNQFQQQQQQQQQQQQQQQQQQHPISNNNSLGGAGGGAPQPGPDMEQPQHGGAKDSAAGGQADPPGPPLLS
KPGDEDDAPPKMGEPAGGRYEHPGLGALGTQQPPVAVPGGGGGPAAVPEFNNYYGSAAPASGGPGGRAGPCFDQHGGQQSPGMGMMHSAS
AAAAGAPGSMDPLQNSHEGYPNSQCNHYPGYSRPGAGGGGGGGGGGGGGSGGGGGGGGAGAGGAGAGAVAAAAAAAAAAAGGGGGGGYGG
SSAGYGVLSSPRQQGGGMMMGPGGGGAASLSKAAAGSAAGGFQRFAGQNQHPSGATPTLNQLLTSPSPMMRSYGGSYPEYSSPSAPPPPP
SQPQSQAAAAGAAAGGQQAAAGMGLGKDMGAQYAAASPAWAAAQQRSHPAMSPGTPGPTMGRSQGSPMDPMVMKRPQLYGMGSNPHSQPQ
QSSPYPGGSYGPPGPQRYPIGIQGRTPGAMAGMQYPQQQMPPQYGQQGVSGYCQQGQQPYYSQQPQPPHLPPQAQYLPSQSQQRYQPQQD
MSQEGYGTRSQPPLAPGKPNHEDLNLIQQERPSSLPETDLILTFNISMHRSWWMENGPGCTVTSVTPAPDWAPEDHRYITVSGCLLEYQY

--------------------------------------------------------------

>6409_6409_4_ARID1B-NKAIN2_ARID1B_chr6_157256710_ENST00000367148_NKAIN2_chr6_124979332_ENST00000368417_length(amino acids)=783AA_BP=664
MAHNAGAAAAAGTHSAKSGGSEAALKEGGSAAALSSSSSSSAAAAAASSSSSSGPGSAMETGLLPNHKLKTVGEAPAAPPHQQHHHHHHA
HHHHHHAHHLHHHHALQQQLNQFQQQQQQQQQQQQQQQQQQHPISNNNSLGGAGGGAPQPGPDMEQPQHGGAKDSAAGGQADPPGPPLLS
KPGDEDDAPPKMGEPAGGRYEHPGLGALGTQQPPVAVPGGGGGPAAVPEFNNYYGSAAPASGGPGGRAGPCFDQHGGQQSPGMGMMHSAS
AAAAGAPGSMDPLQNSHEGYPNSQCNHYPGYSRPGAGGGGGGGGGGGGGSGGGGGGGGAGAGGAGAGAVAAAAAAAAAAAGGGGGGGYGG
SSAGYGVLSSPRQQGGGMMMGPGGGGAASLSKAAAGSAAGGFQRFAGQNQHPSGATPTLNQLLTSPSPMMRSYGGSYPEYSSPSAPPPPP
SQPQSQAAAAGAAAGGQQAAAGMGLGKDMGAQYAAASPAWAAAQQRSHPAMSPGTPGPTMGRSQGSPMDPMVMKRPQLYGMGSNPHSQPQ
QSSPYPGGSYGPPGPQRYPIGIQGRTPGAMAGMQYPQQQMPPQYGQQGVSGYCQQGQQPYYSQQPQPPHLPPQAQYLPSQSQQRYQPQQD
MSQEGYGTRSQPPLAPGKPNHEDLNLIQQERPSSLPETDLILTFNISMHRSWWMENGPGCTVTSVTPAPDWAPEDHRYITVSGCLLEYQY

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr6:157256710/chr6:124979332)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ARID1B

Q8NFD5

NKAIN2

Q5VXU1

FUNCTION: Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth (By similarity). Binds DNA non-specifically (PubMed:14982958, PubMed:15170388). {ECO:0000250|UniProtKB:E9Q4N7, ECO:0000269|PubMed:14982958, ECO:0000269|PubMed:15170388, ECO:0000303|PubMed:12672490, ECO:0000303|PubMed:22952240, ECO:0000303|PubMed:26601204}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneARID1Bchr6:157256710chr6:124979332ENST00000346085+520107_131679.02250.0Compositional biasNote=Gln-rich
HgeneARID1Bchr6:157256710chr6:124979332ENST00000346085+520114_131679.02250.0Compositional biasNote=Poly-Gln
HgeneARID1Bchr6:157256710chr6:124979332ENST00000346085+520141_401679.02250.0Compositional biasNote=Gly-rich
HgeneARID1Bchr6:157256710chr6:124979332ENST00000346085+5202_47679.02250.0Compositional biasNote=Ala-rich
HgeneARID1Bchr6:157256710chr6:124979332ENST00000346085+520329_493679.02250.0Compositional biasNote=Ala-rich
HgeneARID1Bchr6:157256710chr6:124979332ENST00000346085+52035_57679.02250.0Compositional biasNote=Ser-rich
HgeneARID1Bchr6:157256710chr6:124979332ENST00000346085+520574_633679.02250.0Compositional biasNote=Gln-rich
HgeneARID1Bchr6:157256710chr6:124979332ENST00000346085+52081_104679.02250.0Compositional biasNote=His-rich
HgeneARID1Bchr6:157256710chr6:124979332ENST00000350026+419107_131666.02237.0Compositional biasNote=Gln-rich
HgeneARID1Bchr6:157256710chr6:124979332ENST00000350026+419114_131666.02237.0Compositional biasNote=Poly-Gln
HgeneARID1Bchr6:157256710chr6:124979332ENST00000350026+419141_401666.02237.0Compositional biasNote=Gly-rich
HgeneARID1Bchr6:157256710chr6:124979332ENST00000350026+4192_47666.02237.0Compositional biasNote=Ala-rich
HgeneARID1Bchr6:157256710chr6:124979332ENST00000350026+419329_493666.02237.0Compositional biasNote=Ala-rich
HgeneARID1Bchr6:157256710chr6:124979332ENST00000350026+41935_57666.02237.0Compositional biasNote=Ser-rich
HgeneARID1Bchr6:157256710chr6:124979332ENST00000350026+419574_633666.02237.0Compositional biasNote=Gln-rich
HgeneARID1Bchr6:157256710chr6:124979332ENST00000350026+41981_104666.02237.0Compositional biasNote=His-rich
HgeneARID1Bchr6:157256710chr6:124979332ENST00000367148+420107_131666.02290.0Compositional biasNote=Gln-rich
HgeneARID1Bchr6:157256710chr6:124979332ENST00000367148+420114_131666.02290.0Compositional biasNote=Poly-Gln
HgeneARID1Bchr6:157256710chr6:124979332ENST00000367148+420141_401666.02290.0Compositional biasNote=Gly-rich
HgeneARID1Bchr6:157256710chr6:124979332ENST00000367148+4202_47666.02290.0Compositional biasNote=Ala-rich
HgeneARID1Bchr6:157256710chr6:124979332ENST00000367148+420329_493666.02290.0Compositional biasNote=Ala-rich
HgeneARID1Bchr6:157256710chr6:124979332ENST00000367148+42035_57666.02290.0Compositional biasNote=Ser-rich
HgeneARID1Bchr6:157256710chr6:124979332ENST00000367148+420574_633666.02290.0Compositional biasNote=Gln-rich
HgeneARID1Bchr6:157256710chr6:124979332ENST00000367148+42081_104666.02290.0Compositional biasNote=His-rich
HgeneARID1Bchr6:157256710chr6:124979332ENST00000346085+520419_423679.02250.0MotifNote=LXXLL
HgeneARID1Bchr6:157256710chr6:124979332ENST00000350026+419419_423666.02237.0MotifNote=LXXLL
HgeneARID1Bchr6:157256710chr6:124979332ENST00000367148+420419_423666.02290.0MotifNote=LXXLL
TgeneNKAIN2chr6:157256710chr6:124979332ENST0000036841624153_17391.0189.0TransmembraneHelical
TgeneNKAIN2chr6:157256710chr6:124979332ENST0000036841727153_17391.0209.0TransmembraneHelical

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneARID1Bchr6:157256710chr6:124979332ENST00000346085+5201034_1037679.02250.0Compositional biasNote=Poly-Ser
HgeneARID1Bchr6:157256710chr6:124979332ENST00000346085+5201441_1444679.02250.0Compositional biasNote=Poly-Ser
HgeneARID1Bchr6:157256710chr6:124979332ENST00000346085+5201459_1597679.02250.0Compositional biasNote=Pro-rich
HgeneARID1Bchr6:157256710chr6:124979332ENST00000346085+5201833_1836679.02250.0Compositional biasNote=Poly-Pro
HgeneARID1Bchr6:157256710chr6:124979332ENST00000346085+520684_771679.02250.0Compositional biasNote=Ser-rich
HgeneARID1Bchr6:157256710chr6:124979332ENST00000346085+520932_935679.02250.0Compositional biasNote=Poly-Ala
HgeneARID1Bchr6:157256710chr6:124979332ENST00000350026+4191034_1037666.02237.0Compositional biasNote=Poly-Ser
HgeneARID1Bchr6:157256710chr6:124979332ENST00000350026+4191441_1444666.02237.0Compositional biasNote=Poly-Ser
HgeneARID1Bchr6:157256710chr6:124979332ENST00000350026+4191459_1597666.02237.0Compositional biasNote=Pro-rich
HgeneARID1Bchr6:157256710chr6:124979332ENST00000350026+4191833_1836666.02237.0Compositional biasNote=Poly-Pro
HgeneARID1Bchr6:157256710chr6:124979332ENST00000350026+419684_771666.02237.0Compositional biasNote=Ser-rich
HgeneARID1Bchr6:157256710chr6:124979332ENST00000350026+419932_935666.02237.0Compositional biasNote=Poly-Ala
HgeneARID1Bchr6:157256710chr6:124979332ENST00000367148+4201034_1037666.02290.0Compositional biasNote=Poly-Ser
HgeneARID1Bchr6:157256710chr6:124979332ENST00000367148+4201441_1444666.02290.0Compositional biasNote=Poly-Ser
HgeneARID1Bchr6:157256710chr6:124979332ENST00000367148+4201459_1597666.02290.0Compositional biasNote=Pro-rich
HgeneARID1Bchr6:157256710chr6:124979332ENST00000367148+4201833_1836666.02290.0Compositional biasNote=Poly-Pro
HgeneARID1Bchr6:157256710chr6:124979332ENST00000367148+420684_771666.02290.0Compositional biasNote=Ser-rich
HgeneARID1Bchr6:157256710chr6:124979332ENST00000367148+420932_935666.02290.0Compositional biasNote=Poly-Ala
HgeneARID1Bchr6:157256710chr6:124979332ENST00000346085+5201053_1144679.02250.0DomainARID
HgeneARID1Bchr6:157256710chr6:124979332ENST00000350026+4191053_1144666.02237.0DomainARID
HgeneARID1Bchr6:157256710chr6:124979332ENST00000367148+4201053_1144666.02290.0DomainARID
HgeneARID1Bchr6:157256710chr6:124979332ENST00000346085+5201358_1377679.02250.0MotifNuclear localization signal
HgeneARID1Bchr6:157256710chr6:124979332ENST00000346085+5202036_2040679.02250.0MotifNote=LXXLL
HgeneARID1Bchr6:157256710chr6:124979332ENST00000350026+4191358_1377666.02237.0MotifNuclear localization signal
HgeneARID1Bchr6:157256710chr6:124979332ENST00000350026+4192036_2040666.02237.0MotifNote=LXXLL
HgeneARID1Bchr6:157256710chr6:124979332ENST00000367148+4201358_1377666.02290.0MotifNuclear localization signal
HgeneARID1Bchr6:157256710chr6:124979332ENST00000367148+4202036_2040666.02290.0MotifNote=LXXLL
TgeneNKAIN2chr6:157256710chr6:124979332ENST00000368416241_2391.0189.0TransmembraneHelical
TgeneNKAIN2chr6:157256710chr6:124979332ENST000003684162435_5591.0189.0TransmembraneHelical
TgeneNKAIN2chr6:157256710chr6:124979332ENST000003684162462_8291.0189.0TransmembraneHelical
TgeneNKAIN2chr6:157256710chr6:124979332ENST00000368417271_2391.0209.0TransmembraneHelical
TgeneNKAIN2chr6:157256710chr6:124979332ENST000003684172735_5591.0209.0TransmembraneHelical
TgeneNKAIN2chr6:157256710chr6:124979332ENST000003684172762_8291.0209.0TransmembraneHelical


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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
ARID1B
NKAIN2


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to ARID1B-NKAIN2


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to ARID1B-NKAIN2


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource