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Fusion Protein:ARID1B-RCN2 |
Fusion Protein Summary |
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Fusion partner gene information | Fusion gene name: ARID1B-RCN2 | FusionPDB ID: 6416 | FusionGDB2.0 ID: 6416 | Hgene | Tgene | Gene symbol | ARID1B | RCN2 | Gene ID | 57492 | 10231 |
Gene name | AT-rich interaction domain 1B | regulator of calcineurin 2 | |
Synonyms | 6A3-5|BAF250B|BRIGHT|CSS1|DAN15|ELD/OSA1|MRD12|OSA2|P250R | CSP2|DSCR1L1|MCIP2|RCN2|ZAKI-4|ZAKI4 | |
Cytomap | 6q25.3 | 6p12.3 | |
Type of gene | protein-coding | protein-coding | |
Description | AT-rich interactive domain-containing protein 1BARID domain-containing protein 1BAT rich interactive domain 1B (SWI1-like)BRG1-associated factor 250bBRG1-binding protein ELD/OSA1ELD (eyelid)/OSA protein | calcipressin-2Down syndrome candidate region 1-like 1Down syndrome critical region gene 1-like 1myocyte-enriched calcineurin-interacting protein 2thyroid hormone-responsive (skin fibroblasts)thyroid hormone-responsive protein ZAKI-4 | |
Modification date | 20200320 | 20200313 | |
UniProtAcc | Q8NFD5 | . | |
Ensembl transtripts involved in fusion gene | ENST ids | ENST00000275248, ENST00000346085, ENST00000350026, ENST00000367148, ENST00000478761, | ENST00000394883, ENST00000320963, ENST00000394885, |
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0) | * DoF score | 27 X 18 X 14=6804 | 10 X 7 X 6=420 |
# samples | 31 | 11 | |
** MAII score | log2(31/6804*10)=-4.45604302038915 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(11/420*10)=-1.93288580414146 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context (manual curation of fusion genes in FusionPDB) | PubMed: ARID1B [Title/Abstract] AND RCN2 [Title/Abstract] AND fusion [Title/Abstract] | ||
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0) | ARID1B(157150555)-RCN2(77224702), # samples:2 | ||
Anticipated loss of major functional domain due to fusion event. | ARID1B-RCN2 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. ARID1B-RCN2 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. ARID1B-RCN2 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. ARID1B-RCN2 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
![]() * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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![]() * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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Fusion Gene Sample Information |
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![]() * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChimerDB4 | SKCM | TCGA-ER-A197-06A | ARID1B | chr6 | 157150555 | + | RCN2 | chr15 | 77224702 | + |
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Fusion ORF Analysis |
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Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
ENST00000350026 | ARID1B | chr6 | 157150555 | + | ENST00000394885 | RCN2 | chr15 | 77224702 | + | 3586 | 1738 | 1 | 2547 | 848 |
ENST00000350026 | ARID1B | chr6 | 157150555 | + | ENST00000320963 | RCN2 | chr15 | 77224702 | + | 3240 | 1738 | 1 | 2601 | 866 |
ENST00000346085 | ARID1B | chr6 | 157150555 | + | ENST00000394885 | RCN2 | chr15 | 77224702 | + | 3586 | 1738 | 1 | 2547 | 848 |
ENST00000346085 | ARID1B | chr6 | 157150555 | + | ENST00000320963 | RCN2 | chr15 | 77224702 | + | 3240 | 1738 | 1 | 2601 | 866 |
ENST00000367148 | ARID1B | chr6 | 157150555 | + | ENST00000394885 | RCN2 | chr15 | 77224702 | + | 3585 | 1737 | 0 | 2546 | 848 |
ENST00000367148 | ARID1B | chr6 | 157150555 | + | ENST00000320963 | RCN2 | chr15 | 77224702 | + | 3239 | 1737 | 0 | 2600 | 866 |
ENST00000275248 | ARID1B | chr6 | 157150555 | + | ENST00000394885 | RCN2 | chr15 | 77224702 | + | 3563 | 1715 | 77 | 2524 | 815 |
ENST00000275248 | ARID1B | chr6 | 157150555 | + | ENST00000320963 | RCN2 | chr15 | 77224702 | + | 3217 | 1715 | 77 | 2578 | 833 |
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Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
ENST00000350026 | ENST00000394885 | ARID1B | chr6 | 157150555 | + | RCN2 | chr15 | 77224702 | + | 0.004970748 | 0.9950293 |
ENST00000350026 | ENST00000320963 | ARID1B | chr6 | 157150555 | + | RCN2 | chr15 | 77224702 | + | 0.006867237 | 0.99313277 |
ENST00000346085 | ENST00000394885 | ARID1B | chr6 | 157150555 | + | RCN2 | chr15 | 77224702 | + | 0.004970748 | 0.9950293 |
ENST00000346085 | ENST00000320963 | ARID1B | chr6 | 157150555 | + | RCN2 | chr15 | 77224702 | + | 0.006867237 | 0.99313277 |
ENST00000367148 | ENST00000394885 | ARID1B | chr6 | 157150555 | + | RCN2 | chr15 | 77224702 | + | 0.004958393 | 0.99504167 |
ENST00000367148 | ENST00000320963 | ARID1B | chr6 | 157150555 | + | RCN2 | chr15 | 77224702 | + | 0.006851999 | 0.993148 |
ENST00000275248 | ENST00000394885 | ARID1B | chr6 | 157150555 | + | RCN2 | chr15 | 77224702 | + | 0.007360536 | 0.99263954 |
ENST00000275248 | ENST00000320963 | ARID1B | chr6 | 157150555 | + | RCN2 | chr15 | 77224702 | + | 0.009226111 | 0.99077386 |
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Fusion Amino Acid Sequences |
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>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP >6416_6416_1_ARID1B-RCN2_ARID1B_chr6_157150555_ENST00000275248_RCN2_chr15_77224702_ENST00000320963_length(amino acids)=833AA_BP=268 MSSSSSSSAAAAAASSSSSSGPGSAMETGLLPNHKLKTVGEAPAAPPHQQHHHHHHAHHHHHHAHHLHHHHALQQQLNQFQQQQQQQQQQ QQQQQQQQHPISNNNSLGGAGGGAPQPGPDMEQPQHGGAKDSAAGGQADPPGPPLLSKPGDEDDAPPKMGEPAGGRYEHPGLGALGTQQP PVAVPGGGGGPAAVPEFNNYYGSAAPASGGPGGRAGPCFDQHGGQQSPGMGMMHSASAAAAGAPGSMDPLQNSHEGYPNSQCNHYPGYSR PGAGGGGGGGGGGGGGSGGGGGGGGAGAGGAGAGAVAAAAAAAAAAAGGGGGGGYGGSSAGYGVLSSPRQQGGGMMMGPGGGGAASLSKA AAGSAAGGFQRFAGQNQHPSGATPTLNQLLTSPSPMMRSYGGSYPEYSSPSAPPPPPSQPQSQAAAAGAAAGGQQAAAGMGLGKDMGAQY AAASPAWAAAQQRSHPAMSPGTPGPTMGRSQGSPMDPMVMKRPQLYGMGSNPHSQPQQSSPYPGGSYGPPGPQRYPIGIQGRTPGAMAGM QYPQQQEDVDEYVKLGHEEQQKRLQAIIKKIDLDSDGFLTESELSSWIQMSFKHYAMQEAKQQFVEYDKNSDDTVTWDEYNIQMYDRVID FDENTALDDAEEESFRKEFAICKKQSFCFWLLRFNLHLKDKKRFEKANQDSGPGLSLEEFIAFEHPEEVDYMTEFVIQEALEEHDKNGDG FVSLEEFLGDYRWDPTANEDPEWILVEKDRFVNDYDKDNDGRLDPQELLPWVVPNNQGIAQEEALHLIDEMDLNGDKKLSEEEILENPDL -------------------------------------------------------------- >6416_6416_2_ARID1B-RCN2_ARID1B_chr6_157150555_ENST00000275248_RCN2_chr15_77224702_ENST00000394885_length(amino acids)=815AA_BP=268 MSSSSSSSAAAAAASSSSSSGPGSAMETGLLPNHKLKTVGEAPAAPPHQQHHHHHHAHHHHHHAHHLHHHHALQQQLNQFQQQQQQQQQQ QQQQQQQQHPISNNNSLGGAGGGAPQPGPDMEQPQHGGAKDSAAGGQADPPGPPLLSKPGDEDDAPPKMGEPAGGRYEHPGLGALGTQQP PVAVPGGGGGPAAVPEFNNYYGSAAPASGGPGGRAGPCFDQHGGQQSPGMGMMHSASAAAAGAPGSMDPLQNSHEGYPNSQCNHYPGYSR PGAGGGGGGGGGGGGGSGGGGGGGGAGAGGAGAGAVAAAAAAAAAAAGGGGGGGYGGSSAGYGVLSSPRQQGGGMMMGPGGGGAASLSKA AAGSAAGGFQRFAGQNQHPSGATPTLNQLLTSPSPMMRSYGGSYPEYSSPSAPPPPPSQPQSQAAAAGAAAGGQQAAAGMGLGKDMGAQY AAASPAWAAAQQRSHPAMSPGTPGPTMGRSQGSPMDPMVMKRPQLYGMGSNPHSQPQQSSPYPGGSYGPPGPQRYPIGIQGRTPGAMAGM QYPQQQEDVDEYVKLGHEEQQKRLQAIIKKIDLDSDGFLTESELSSWIQMSFKHYAMQEAKQQFVEYDKNSDDTVTWDEYNIQMYDRVID FDENTALDDAEEESFRKLHLKDKKRFEKANQDSGPGLSLEEFIAFEHPEEVDYMTEFVIQEALEEHDKNGDGFVSLEEFLGDYRWDPTAN EDPEWILVEKDRFVNDYDKDNDGRLDPQELLPWVVPNNQGIAQEEALHLIDEMDLNGDKKLSEEEILENPDLFLTSEATDYGRQLHDDYF -------------------------------------------------------------- >6416_6416_3_ARID1B-RCN2_ARID1B_chr6_157150555_ENST00000346085_RCN2_chr15_77224702_ENST00000320963_length(amino acids)=866AA_BP=301 MAHNAGAAAAAGTHSAKSGGSEAALKEGGSAAALSSSSSSSAAAAAASSSSSSGPGSAMETGLLPNHKLKTVGEAPAAPPHQQHHHHHHA HHHHHHAHHLHHHHALQQQLNQFQQQQQQQQQQQQQQQQQQHPISNNNSLGGAGGGAPQPGPDMEQPQHGGAKDSAAGGQADPPGPPLLS KPGDEDDAPPKMGEPAGGRYEHPGLGALGTQQPPVAVPGGGGGPAAVPEFNNYYGSAAPASGGPGGRAGPCFDQHGGQQSPGMGMMHSAS AAAAGAPGSMDPLQNSHEGYPNSQCNHYPGYSRPGAGGGGGGGGGGGGGSGGGGGGGGAGAGGAGAGAVAAAAAAAAAAAGGGGGGGYGG SSAGYGVLSSPRQQGGGMMMGPGGGGAASLSKAAAGSAAGGFQRFAGQNQHPSGATPTLNQLLTSPSPMMRSYGGSYPEYSSPSAPPPPP SQPQSQAAAAGAAAGGQQAAAGMGLGKDMGAQYAAASPAWAAAQQRSHPAMSPGTPGPTMGRSQGSPMDPMVMKRPQLYGMGSNPHSQPQ QSSPYPGGSYGPPGPQRYPIGIQGRTPGAMAGMQYPQQQEDVDEYVKLGHEEQQKRLQAIIKKIDLDSDGFLTESELSSWIQMSFKHYAM QEAKQQFVEYDKNSDDTVTWDEYNIQMYDRVIDFDENTALDDAEEESFRKEFAICKKQSFCFWLLRFNLHLKDKKRFEKANQDSGPGLSL EEFIAFEHPEEVDYMTEFVIQEALEEHDKNGDGFVSLEEFLGDYRWDPTANEDPEWILVEKDRFVNDYDKDNDGRLDPQELLPWVVPNNQ -------------------------------------------------------------- >6416_6416_4_ARID1B-RCN2_ARID1B_chr6_157150555_ENST00000346085_RCN2_chr15_77224702_ENST00000394885_length(amino acids)=848AA_BP=301 MAHNAGAAAAAGTHSAKSGGSEAALKEGGSAAALSSSSSSSAAAAAASSSSSSGPGSAMETGLLPNHKLKTVGEAPAAPPHQQHHHHHHA HHHHHHAHHLHHHHALQQQLNQFQQQQQQQQQQQQQQQQQQHPISNNNSLGGAGGGAPQPGPDMEQPQHGGAKDSAAGGQADPPGPPLLS KPGDEDDAPPKMGEPAGGRYEHPGLGALGTQQPPVAVPGGGGGPAAVPEFNNYYGSAAPASGGPGGRAGPCFDQHGGQQSPGMGMMHSAS AAAAGAPGSMDPLQNSHEGYPNSQCNHYPGYSRPGAGGGGGGGGGGGGGSGGGGGGGGAGAGGAGAGAVAAAAAAAAAAAGGGGGGGYGG SSAGYGVLSSPRQQGGGMMMGPGGGGAASLSKAAAGSAAGGFQRFAGQNQHPSGATPTLNQLLTSPSPMMRSYGGSYPEYSSPSAPPPPP SQPQSQAAAAGAAAGGQQAAAGMGLGKDMGAQYAAASPAWAAAQQRSHPAMSPGTPGPTMGRSQGSPMDPMVMKRPQLYGMGSNPHSQPQ QSSPYPGGSYGPPGPQRYPIGIQGRTPGAMAGMQYPQQQEDVDEYVKLGHEEQQKRLQAIIKKIDLDSDGFLTESELSSWIQMSFKHYAM QEAKQQFVEYDKNSDDTVTWDEYNIQMYDRVIDFDENTALDDAEEESFRKLHLKDKKRFEKANQDSGPGLSLEEFIAFEHPEEVDYMTEF VIQEALEEHDKNGDGFVSLEEFLGDYRWDPTANEDPEWILVEKDRFVNDYDKDNDGRLDPQELLPWVVPNNQGIAQEEALHLIDEMDLNG -------------------------------------------------------------- >6416_6416_5_ARID1B-RCN2_ARID1B_chr6_157150555_ENST00000350026_RCN2_chr15_77224702_ENST00000320963_length(amino acids)=866AA_BP=301 MAHNAGAAAAAGTHSAKSGGSEAALKEGGSAAALSSSSSSSAAAAAASSSSSSGPGSAMETGLLPNHKLKTVGEAPAAPPHQQHHHHHHA HHHHHHAHHLHHHHALQQQLNQFQQQQQQQQQQQQQQQQQQHPISNNNSLGGAGGGAPQPGPDMEQPQHGGAKDSAAGGQADPPGPPLLS KPGDEDDAPPKMGEPAGGRYEHPGLGALGTQQPPVAVPGGGGGPAAVPEFNNYYGSAAPASGGPGGRAGPCFDQHGGQQSPGMGMMHSAS AAAAGAPGSMDPLQNSHEGYPNSQCNHYPGYSRPGAGGGGGGGGGGGGGSGGGGGGGGAGAGGAGAGAVAAAAAAAAAAAGGGGGGGYGG SSAGYGVLSSPRQQGGGMMMGPGGGGAASLSKAAAGSAAGGFQRFAGQNQHPSGATPTLNQLLTSPSPMMRSYGGSYPEYSSPSAPPPPP SQPQSQAAAAGAAAGGQQAAAGMGLGKDMGAQYAAASPAWAAAQQRSHPAMSPGTPGPTMGRSQGSPMDPMVMKRPQLYGMGSNPHSQPQ QSSPYPGGSYGPPGPQRYPIGIQGRTPGAMAGMQYPQQQEDVDEYVKLGHEEQQKRLQAIIKKIDLDSDGFLTESELSSWIQMSFKHYAM QEAKQQFVEYDKNSDDTVTWDEYNIQMYDRVIDFDENTALDDAEEESFRKEFAICKKQSFCFWLLRFNLHLKDKKRFEKANQDSGPGLSL EEFIAFEHPEEVDYMTEFVIQEALEEHDKNGDGFVSLEEFLGDYRWDPTANEDPEWILVEKDRFVNDYDKDNDGRLDPQELLPWVVPNNQ -------------------------------------------------------------- >6416_6416_6_ARID1B-RCN2_ARID1B_chr6_157150555_ENST00000350026_RCN2_chr15_77224702_ENST00000394885_length(amino acids)=848AA_BP=301 MAHNAGAAAAAGTHSAKSGGSEAALKEGGSAAALSSSSSSSAAAAAASSSSSSGPGSAMETGLLPNHKLKTVGEAPAAPPHQQHHHHHHA HHHHHHAHHLHHHHALQQQLNQFQQQQQQQQQQQQQQQQQQHPISNNNSLGGAGGGAPQPGPDMEQPQHGGAKDSAAGGQADPPGPPLLS KPGDEDDAPPKMGEPAGGRYEHPGLGALGTQQPPVAVPGGGGGPAAVPEFNNYYGSAAPASGGPGGRAGPCFDQHGGQQSPGMGMMHSAS AAAAGAPGSMDPLQNSHEGYPNSQCNHYPGYSRPGAGGGGGGGGGGGGGSGGGGGGGGAGAGGAGAGAVAAAAAAAAAAAGGGGGGGYGG SSAGYGVLSSPRQQGGGMMMGPGGGGAASLSKAAAGSAAGGFQRFAGQNQHPSGATPTLNQLLTSPSPMMRSYGGSYPEYSSPSAPPPPP SQPQSQAAAAGAAAGGQQAAAGMGLGKDMGAQYAAASPAWAAAQQRSHPAMSPGTPGPTMGRSQGSPMDPMVMKRPQLYGMGSNPHSQPQ QSSPYPGGSYGPPGPQRYPIGIQGRTPGAMAGMQYPQQQEDVDEYVKLGHEEQQKRLQAIIKKIDLDSDGFLTESELSSWIQMSFKHYAM QEAKQQFVEYDKNSDDTVTWDEYNIQMYDRVIDFDENTALDDAEEESFRKLHLKDKKRFEKANQDSGPGLSLEEFIAFEHPEEVDYMTEF VIQEALEEHDKNGDGFVSLEEFLGDYRWDPTANEDPEWILVEKDRFVNDYDKDNDGRLDPQELLPWVVPNNQGIAQEEALHLIDEMDLNG -------------------------------------------------------------- >6416_6416_7_ARID1B-RCN2_ARID1B_chr6_157150555_ENST00000367148_RCN2_chr15_77224702_ENST00000320963_length(amino acids)=866AA_BP=301 MAHNAGAAAAAGTHSAKSGGSEAALKEGGSAAALSSSSSSSAAAAAASSSSSSGPGSAMETGLLPNHKLKTVGEAPAAPPHQQHHHHHHA HHHHHHAHHLHHHHALQQQLNQFQQQQQQQQQQQQQQQQQQHPISNNNSLGGAGGGAPQPGPDMEQPQHGGAKDSAAGGQADPPGPPLLS KPGDEDDAPPKMGEPAGGRYEHPGLGALGTQQPPVAVPGGGGGPAAVPEFNNYYGSAAPASGGPGGRAGPCFDQHGGQQSPGMGMMHSAS AAAAGAPGSMDPLQNSHEGYPNSQCNHYPGYSRPGAGGGGGGGGGGGGGSGGGGGGGGAGAGGAGAGAVAAAAAAAAAAAGGGGGGGYGG SSAGYGVLSSPRQQGGGMMMGPGGGGAASLSKAAAGSAAGGFQRFAGQNQHPSGATPTLNQLLTSPSPMMRSYGGSYPEYSSPSAPPPPP SQPQSQAAAAGAAAGGQQAAAGMGLGKDMGAQYAAASPAWAAAQQRSHPAMSPGTPGPTMGRSQGSPMDPMVMKRPQLYGMGSNPHSQPQ QSSPYPGGSYGPPGPQRYPIGIQGRTPGAMAGMQYPQQQEDVDEYVKLGHEEQQKRLQAIIKKIDLDSDGFLTESELSSWIQMSFKHYAM QEAKQQFVEYDKNSDDTVTWDEYNIQMYDRVIDFDENTALDDAEEESFRKEFAICKKQSFCFWLLRFNLHLKDKKRFEKANQDSGPGLSL EEFIAFEHPEEVDYMTEFVIQEALEEHDKNGDGFVSLEEFLGDYRWDPTANEDPEWILVEKDRFVNDYDKDNDGRLDPQELLPWVVPNNQ -------------------------------------------------------------- >6416_6416_8_ARID1B-RCN2_ARID1B_chr6_157150555_ENST00000367148_RCN2_chr15_77224702_ENST00000394885_length(amino acids)=848AA_BP=301 MAHNAGAAAAAGTHSAKSGGSEAALKEGGSAAALSSSSSSSAAAAAASSSSSSGPGSAMETGLLPNHKLKTVGEAPAAPPHQQHHHHHHA HHHHHHAHHLHHHHALQQQLNQFQQQQQQQQQQQQQQQQQQHPISNNNSLGGAGGGAPQPGPDMEQPQHGGAKDSAAGGQADPPGPPLLS KPGDEDDAPPKMGEPAGGRYEHPGLGALGTQQPPVAVPGGGGGPAAVPEFNNYYGSAAPASGGPGGRAGPCFDQHGGQQSPGMGMMHSAS AAAAGAPGSMDPLQNSHEGYPNSQCNHYPGYSRPGAGGGGGGGGGGGGGSGGGGGGGGAGAGGAGAGAVAAAAAAAAAAAGGGGGGGYGG SSAGYGVLSSPRQQGGGMMMGPGGGGAASLSKAAAGSAAGGFQRFAGQNQHPSGATPTLNQLLTSPSPMMRSYGGSYPEYSSPSAPPPPP SQPQSQAAAAGAAAGGQQAAAGMGLGKDMGAQYAAASPAWAAAQQRSHPAMSPGTPGPTMGRSQGSPMDPMVMKRPQLYGMGSNPHSQPQ QSSPYPGGSYGPPGPQRYPIGIQGRTPGAMAGMQYPQQQEDVDEYVKLGHEEQQKRLQAIIKKIDLDSDGFLTESELSSWIQMSFKHYAM QEAKQQFVEYDKNSDDTVTWDEYNIQMYDRVIDFDENTALDDAEEESFRKLHLKDKKRFEKANQDSGPGLSLEEFIAFEHPEEVDYMTEF VIQEALEEHDKNGDGFVSLEEFLGDYRWDPTANEDPEWILVEKDRFVNDYDKDNDGRLDPQELLPWVVPNNQGIAQEEALHLIDEMDLNG -------------------------------------------------------------- |
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Fusion Protein Functional Features |
![]() Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr6:157150555/chr15:77224702) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
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Hgene | Tgene |
ARID1B | . |
FUNCTION: Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth (By similarity). Binds DNA non-specifically (PubMed:14982958, PubMed:15170388). {ECO:0000250|UniProtKB:E9Q4N7, ECO:0000269|PubMed:14982958, ECO:0000269|PubMed:15170388, ECO:0000303|PubMed:12672490, ECO:0000303|PubMed:22952240, ECO:0000303|PubMed:26601204}. | FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes. |
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- Retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Hgene | ARID1B | chr6:157150555 | chr15:77224702 | ENST00000346085 | + | 2 | 20 | 107_131 | 579.0 | 2250.0 | Compositional bias | Note=Gln-rich |
Hgene | ARID1B | chr6:157150555 | chr15:77224702 | ENST00000346085 | + | 2 | 20 | 114_131 | 579.0 | 2250.0 | Compositional bias | Note=Poly-Gln |
Hgene | ARID1B | chr6:157150555 | chr15:77224702 | ENST00000346085 | + | 2 | 20 | 141_401 | 579.0 | 2250.0 | Compositional bias | Note=Gly-rich |
Hgene | ARID1B | chr6:157150555 | chr15:77224702 | ENST00000346085 | + | 2 | 20 | 2_47 | 579.0 | 2250.0 | Compositional bias | Note=Ala-rich |
Hgene | ARID1B | chr6:157150555 | chr15:77224702 | ENST00000346085 | + | 2 | 20 | 329_493 | 579.0 | 2250.0 | Compositional bias | Note=Ala-rich |
Hgene | ARID1B | chr6:157150555 | chr15:77224702 | ENST00000346085 | + | 2 | 20 | 35_57 | 579.0 | 2250.0 | Compositional bias | Note=Ser-rich |
Hgene | ARID1B | chr6:157150555 | chr15:77224702 | ENST00000346085 | + | 2 | 20 | 81_104 | 579.0 | 2250.0 | Compositional bias | Note=His-rich |
Hgene | ARID1B | chr6:157150555 | chr15:77224702 | ENST00000350026 | + | 2 | 19 | 107_131 | 579.0 | 2237.0 | Compositional bias | Note=Gln-rich |
Hgene | ARID1B | chr6:157150555 | chr15:77224702 | ENST00000350026 | + | 2 | 19 | 114_131 | 579.0 | 2237.0 | Compositional bias | Note=Poly-Gln |
Hgene | ARID1B | chr6:157150555 | chr15:77224702 | ENST00000350026 | + | 2 | 19 | 141_401 | 579.0 | 2237.0 | Compositional bias | Note=Gly-rich |
Hgene | ARID1B | chr6:157150555 | chr15:77224702 | ENST00000350026 | + | 2 | 19 | 2_47 | 579.0 | 2237.0 | Compositional bias | Note=Ala-rich |
Hgene | ARID1B | chr6:157150555 | chr15:77224702 | ENST00000350026 | + | 2 | 19 | 329_493 | 579.0 | 2237.0 | Compositional bias | Note=Ala-rich |
Hgene | ARID1B | chr6:157150555 | chr15:77224702 | ENST00000350026 | + | 2 | 19 | 35_57 | 579.0 | 2237.0 | Compositional bias | Note=Ser-rich |
Hgene | ARID1B | chr6:157150555 | chr15:77224702 | ENST00000350026 | + | 2 | 19 | 81_104 | 579.0 | 2237.0 | Compositional bias | Note=His-rich |
Hgene | ARID1B | chr6:157150555 | chr15:77224702 | ENST00000367148 | + | 2 | 20 | 107_131 | 579.0 | 2290.0 | Compositional bias | Note=Gln-rich |
Hgene | ARID1B | chr6:157150555 | chr15:77224702 | ENST00000367148 | + | 2 | 20 | 114_131 | 579.0 | 2290.0 | Compositional bias | Note=Poly-Gln |
Hgene | ARID1B | chr6:157150555 | chr15:77224702 | ENST00000367148 | + | 2 | 20 | 141_401 | 579.0 | 2290.0 | Compositional bias | Note=Gly-rich |
Hgene | ARID1B | chr6:157150555 | chr15:77224702 | ENST00000367148 | + | 2 | 20 | 2_47 | 579.0 | 2290.0 | Compositional bias | Note=Ala-rich |
Hgene | ARID1B | chr6:157150555 | chr15:77224702 | ENST00000367148 | + | 2 | 20 | 329_493 | 579.0 | 2290.0 | Compositional bias | Note=Ala-rich |
Hgene | ARID1B | chr6:157150555 | chr15:77224702 | ENST00000367148 | + | 2 | 20 | 35_57 | 579.0 | 2290.0 | Compositional bias | Note=Ser-rich |
Hgene | ARID1B | chr6:157150555 | chr15:77224702 | ENST00000367148 | + | 2 | 20 | 81_104 | 579.0 | 2290.0 | Compositional bias | Note=His-rich |
Hgene | ARID1B | chr6:157150555 | chr15:77224702 | ENST00000346085 | + | 2 | 20 | 419_423 | 579.0 | 2250.0 | Motif | Note=LXXLL |
Hgene | ARID1B | chr6:157150555 | chr15:77224702 | ENST00000350026 | + | 2 | 19 | 419_423 | 579.0 | 2237.0 | Motif | Note=LXXLL |
Hgene | ARID1B | chr6:157150555 | chr15:77224702 | ENST00000367148 | + | 2 | 20 | 419_423 | 579.0 | 2290.0 | Motif | Note=LXXLL |
Tgene | RCN2 | chr6:157150555 | chr15:77224702 | ENST00000394885 | 0 | 7 | 110_121 | 48.0 | 318.0 | Calcium binding | 2 | |
Tgene | RCN2 | chr6:157150555 | chr15:77224702 | ENST00000394885 | 0 | 7 | 162_173 | 48.0 | 318.0 | Calcium binding | 3%3B possibly ancestral | |
Tgene | RCN2 | chr6:157150555 | chr15:77224702 | ENST00000394885 | 0 | 7 | 199_210 | 48.0 | 318.0 | Calcium binding | 4 | |
Tgene | RCN2 | chr6:157150555 | chr15:77224702 | ENST00000394885 | 0 | 7 | 240_251 | 48.0 | 318.0 | Calcium binding | 5 | |
Tgene | RCN2 | chr6:157150555 | chr15:77224702 | ENST00000394885 | 0 | 7 | 276_287 | 48.0 | 318.0 | Calcium binding | 6 | |
Tgene | RCN2 | chr6:157150555 | chr15:77224702 | ENST00000394885 | 0 | 7 | 74_85 | 48.0 | 318.0 | Calcium binding | 1 | |
Tgene | RCN2 | chr6:157150555 | chr15:77224702 | ENST00000394885 | 0 | 7 | 150_185 | 48.0 | 318.0 | Domain | EF-hand 3 | |
Tgene | RCN2 | chr6:157150555 | chr15:77224702 | ENST00000394885 | 0 | 7 | 186_221 | 48.0 | 318.0 | Domain | EF-hand 4 | |
Tgene | RCN2 | chr6:157150555 | chr15:77224702 | ENST00000394885 | 0 | 7 | 227_262 | 48.0 | 318.0 | Domain | EF-hand 5 | |
Tgene | RCN2 | chr6:157150555 | chr15:77224702 | ENST00000394885 | 0 | 7 | 263_298 | 48.0 | 318.0 | Domain | EF-hand 6 | |
Tgene | RCN2 | chr6:157150555 | chr15:77224702 | ENST00000394885 | 0 | 7 | 61_96 | 48.0 | 318.0 | Domain | EF-hand 1 | |
Tgene | RCN2 | chr6:157150555 | chr15:77224702 | ENST00000394885 | 0 | 7 | 97_132 | 48.0 | 318.0 | Domain | EF-hand 2 | |
Tgene | RCN2 | chr6:157150555 | chr15:77224702 | ENST00000394885 | 0 | 7 | 314_317 | 48.0 | 318.0 | Motif | Prevents secretion from ER |
- Not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Hgene | ARID1B | chr6:157150555 | chr15:77224702 | ENST00000346085 | + | 2 | 20 | 1034_1037 | 579.0 | 2250.0 | Compositional bias | Note=Poly-Ser |
Hgene | ARID1B | chr6:157150555 | chr15:77224702 | ENST00000346085 | + | 2 | 20 | 1441_1444 | 579.0 | 2250.0 | Compositional bias | Note=Poly-Ser |
Hgene | ARID1B | chr6:157150555 | chr15:77224702 | ENST00000346085 | + | 2 | 20 | 1459_1597 | 579.0 | 2250.0 | Compositional bias | Note=Pro-rich |
Hgene | ARID1B | chr6:157150555 | chr15:77224702 | ENST00000346085 | + | 2 | 20 | 1833_1836 | 579.0 | 2250.0 | Compositional bias | Note=Poly-Pro |
Hgene | ARID1B | chr6:157150555 | chr15:77224702 | ENST00000346085 | + | 2 | 20 | 574_633 | 579.0 | 2250.0 | Compositional bias | Note=Gln-rich |
Hgene | ARID1B | chr6:157150555 | chr15:77224702 | ENST00000346085 | + | 2 | 20 | 684_771 | 579.0 | 2250.0 | Compositional bias | Note=Ser-rich |
Hgene | ARID1B | chr6:157150555 | chr15:77224702 | ENST00000346085 | + | 2 | 20 | 932_935 | 579.0 | 2250.0 | Compositional bias | Note=Poly-Ala |
Hgene | ARID1B | chr6:157150555 | chr15:77224702 | ENST00000350026 | + | 2 | 19 | 1034_1037 | 579.0 | 2237.0 | Compositional bias | Note=Poly-Ser |
Hgene | ARID1B | chr6:157150555 | chr15:77224702 | ENST00000350026 | + | 2 | 19 | 1441_1444 | 579.0 | 2237.0 | Compositional bias | Note=Poly-Ser |
Hgene | ARID1B | chr6:157150555 | chr15:77224702 | ENST00000350026 | + | 2 | 19 | 1459_1597 | 579.0 | 2237.0 | Compositional bias | Note=Pro-rich |
Hgene | ARID1B | chr6:157150555 | chr15:77224702 | ENST00000350026 | + | 2 | 19 | 1833_1836 | 579.0 | 2237.0 | Compositional bias | Note=Poly-Pro |
Hgene | ARID1B | chr6:157150555 | chr15:77224702 | ENST00000350026 | + | 2 | 19 | 574_633 | 579.0 | 2237.0 | Compositional bias | Note=Gln-rich |
Hgene | ARID1B | chr6:157150555 | chr15:77224702 | ENST00000350026 | + | 2 | 19 | 684_771 | 579.0 | 2237.0 | Compositional bias | Note=Ser-rich |
Hgene | ARID1B | chr6:157150555 | chr15:77224702 | ENST00000350026 | + | 2 | 19 | 932_935 | 579.0 | 2237.0 | Compositional bias | Note=Poly-Ala |
Hgene | ARID1B | chr6:157150555 | chr15:77224702 | ENST00000367148 | + | 2 | 20 | 1034_1037 | 579.0 | 2290.0 | Compositional bias | Note=Poly-Ser |
Hgene | ARID1B | chr6:157150555 | chr15:77224702 | ENST00000367148 | + | 2 | 20 | 1441_1444 | 579.0 | 2290.0 | Compositional bias | Note=Poly-Ser |
Hgene | ARID1B | chr6:157150555 | chr15:77224702 | ENST00000367148 | + | 2 | 20 | 1459_1597 | 579.0 | 2290.0 | Compositional bias | Note=Pro-rich |
Hgene | ARID1B | chr6:157150555 | chr15:77224702 | ENST00000367148 | + | 2 | 20 | 1833_1836 | 579.0 | 2290.0 | Compositional bias | Note=Poly-Pro |
Hgene | ARID1B | chr6:157150555 | chr15:77224702 | ENST00000367148 | + | 2 | 20 | 574_633 | 579.0 | 2290.0 | Compositional bias | Note=Gln-rich |
Hgene | ARID1B | chr6:157150555 | chr15:77224702 | ENST00000367148 | + | 2 | 20 | 684_771 | 579.0 | 2290.0 | Compositional bias | Note=Ser-rich |
Hgene | ARID1B | chr6:157150555 | chr15:77224702 | ENST00000367148 | + | 2 | 20 | 932_935 | 579.0 | 2290.0 | Compositional bias | Note=Poly-Ala |
Hgene | ARID1B | chr6:157150555 | chr15:77224702 | ENST00000346085 | + | 2 | 20 | 1053_1144 | 579.0 | 2250.0 | Domain | ARID |
Hgene | ARID1B | chr6:157150555 | chr15:77224702 | ENST00000350026 | + | 2 | 19 | 1053_1144 | 579.0 | 2237.0 | Domain | ARID |
Hgene | ARID1B | chr6:157150555 | chr15:77224702 | ENST00000367148 | + | 2 | 20 | 1053_1144 | 579.0 | 2290.0 | Domain | ARID |
Hgene | ARID1B | chr6:157150555 | chr15:77224702 | ENST00000346085 | + | 2 | 20 | 1358_1377 | 579.0 | 2250.0 | Motif | Nuclear localization signal |
Hgene | ARID1B | chr6:157150555 | chr15:77224702 | ENST00000346085 | + | 2 | 20 | 2036_2040 | 579.0 | 2250.0 | Motif | Note=LXXLL |
Hgene | ARID1B | chr6:157150555 | chr15:77224702 | ENST00000350026 | + | 2 | 19 | 1358_1377 | 579.0 | 2237.0 | Motif | Nuclear localization signal |
Hgene | ARID1B | chr6:157150555 | chr15:77224702 | ENST00000350026 | + | 2 | 19 | 2036_2040 | 579.0 | 2237.0 | Motif | Note=LXXLL |
Hgene | ARID1B | chr6:157150555 | chr15:77224702 | ENST00000367148 | + | 2 | 20 | 1358_1377 | 579.0 | 2290.0 | Motif | Nuclear localization signal |
Hgene | ARID1B | chr6:157150555 | chr15:77224702 | ENST00000367148 | + | 2 | 20 | 2036_2040 | 579.0 | 2290.0 | Motif | Note=LXXLL |
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Fusion Protein-Protein Interaction |
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Gene | PPI interactors |
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Gene | STRING network |
ARID1B | |
RCN2 |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs to ARID1B-RCN2 |
![]() (Manual curation of PubMed, 04-30-2022 + MyCancerGenome) |
Hgene | Tgene | Drug | Source | PMID |
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Related Diseases to ARID1B-RCN2 |
![]() (Manual curation of PubMed, 04-30-2022 + MyCancerGenome) |
Hgene | Tgene | Disease | Source | PMID |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |