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Fusion Protein:PDZRN3-FOXP1 |
Fusion Protein Summary |
 Fusion gene summary |
| Fusion partner gene information | Fusion gene name: PDZRN3-FOXP1 | FusionPDB ID: 64173 | FusionGDB2.0 ID: 64173 | Hgene | Tgene | Gene symbol | PDZRN3 | FOXP1 | Gene ID | 23024 | 27086 |
| Gene name | PDZ domain containing ring finger 3 | forkhead box P1 | |
| Synonyms | LNX3|SEMACAP3|SEMCAP3 | 12CC4|HSPC215|MFH|QRF1|hFKH1B | |
| Cytomap | 3p13 | 3p13 | |
| Type of gene | protein-coding | protein-coding | |
| Description | E3 ubiquitin-protein ligase PDZRN3RING-type E3 ubiquitin transferase PDZRN3ligand of Numb protein X 3likely ortholog of mouse semaF cytoplasmic domain associated protein 3semaphorin cytoplasmic domain-associated protein 3 | forkhead box protein P1fork head-related protein like Bglutamine-rich factor 1mac-1-regulated forkhead | |
| Modification date | 20200313 | 20200329 | |
| UniProtAcc | . | Q9H334 | |
| Ensembl transtripts involved in fusion gene | ENST ids | ENST00000263666, ENST00000308537, ENST00000462146, ENST00000466348, ENST00000466780, ENST00000479530, ENST00000535920, | ENST00000318779, ENST00000468577, ENST00000472382, ENST00000484350, ENST00000491238, ENST00000498215, ENST00000318789, ENST00000475937, ENST00000493089, |
| Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0) | * DoF score | 10 X 6 X 6=360 | 47 X 26 X 20=24440 |
| # samples | 12 | 52 | |
| ** MAII score | log2(12/360*10)=-1.58496250072116 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(52/24440*10)=-5.55458885167764 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context (manual curation of fusion genes in FusionPDB) | PubMed: PDZRN3 [Title/Abstract] AND FOXP1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0) | FOXP1(71026793)-PDZRN3(73453546), # samples:1 PDZRN3(73651505)-FOXP1(71102924), # samples:1 | ||
| Anticipated loss of major functional domain due to fusion event. | FOXP1-PDZRN3 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. FOXP1-PDZRN3 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. PDZRN3-FOXP1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. PDZRN3-FOXP1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. PDZRN3-FOXP1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. PDZRN3-FOXP1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. FOXP1-PDZRN3 seems lost the major protein functional domain in Hgene partner, which is a CGC due to the frame-shifted ORF. FOXP1-PDZRN3 seems lost the major protein functional domain in Hgene partner, which is a epigenetic factor due to the frame-shifted ORF. FOXP1-PDZRN3 seems lost the major protein functional domain in Hgene partner, which is a transcription factor due to the frame-shifted ORF. FOXP1-PDZRN3 seems lost the major protein functional domain in Hgene partner, which is a tumor suppressor due to the frame-shifted ORF. FOXP1-PDZRN3 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | FOXP1 | GO:0002903 | negative regulation of B cell apoptotic process | 25267198 |
| Tgene | FOXP1 | GO:0010629 | negative regulation of gene expression | 30111844 |
| Tgene | FOXP1 | GO:0030316 | osteoclast differentiation | 18799727 |
| Tgene | FOXP1 | GO:0032496 | response to lipopolysaccharide | 18799727 |
| Tgene | FOXP1 | GO:0032680 | regulation of tumor necrosis factor production | 18799727 |
| Tgene | FOXP1 | GO:0035926 | chemokine (C-C motif) ligand 2 secretion | 18799727 |
| Tgene | FOXP1 | GO:0036035 | osteoclast development | 18799727 |
| Tgene | FOXP1 | GO:0042116 | macrophage activation | 18799727 |
| Tgene | FOXP1 | GO:0042117 | monocyte activation | 18799727 |
| Tgene | FOXP1 | GO:0045655 | regulation of monocyte differentiation | 15286807 |
| Tgene | FOXP1 | GO:0045892 | negative regulation of transcription, DNA-templated | 20950788 |
| Tgene | FOXP1 | GO:0050706 | regulation of interleukin-1 beta secretion | 18799727 |
| Tgene | FOXP1 | GO:0050727 | regulation of inflammatory response | 18799727 |
| Tgene | FOXP1 | GO:0060766 | negative regulation of androgen receptor signaling pathway | 18640093 |
| Tgene | FOXP1 | GO:1900424 | regulation of defense response to bacterium | 18799727 |
| Tgene | FOXP1 | GO:1901256 | regulation of macrophage colony-stimulating factor production | 18799727 |
| Tgene | FOXP1 | GO:2001182 | regulation of interleukin-12 secretion | 18799727 |
| Fusion gene breakpoints across PDZRN3 (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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| Fusion gene breakpoints across FOXP1 (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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Fusion Gene Sample Information |
| Fusion gene information from FusionGDB2.0. |
| Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChimerDB4 | PRAD | TCGA-G9-7509-01A | PDZRN3 | chr3 | 73651505 | - | FOXP1 | chr3 | 71102924 | - |
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Fusion ORF Analysis |
| Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
| ENST00000263666 | PDZRN3 | chr3 | 73651505 | - | ENST00000318789 | FOXP1 | chr3 | 71102924 | - | 7339 | 1033 | 103 | 2784 | 893 |
| ENST00000263666 | PDZRN3 | chr3 | 73651505 | - | ENST00000475937 | FOXP1 | chr3 | 71102924 | - | 5287 | 1033 | 103 | 2784 | 893 |
| ENST00000263666 | PDZRN3 | chr3 | 73651505 | - | ENST00000493089 | FOXP1 | chr3 | 71102924 | - | 2825 | 1033 | 103 | 2781 | 892 |
| ENST00000308537 | PDZRN3 | chr3 | 73651505 | - | ENST00000318789 | FOXP1 | chr3 | 71102924 | - | 7239 | 933 | 3 | 2684 | 893 |
| ENST00000308537 | PDZRN3 | chr3 | 73651505 | - | ENST00000475937 | FOXP1 | chr3 | 71102924 | - | 5187 | 933 | 3 | 2684 | 893 |
| ENST00000308537 | PDZRN3 | chr3 | 73651505 | - | ENST00000493089 | FOXP1 | chr3 | 71102924 | - | 2725 | 933 | 3 | 2681 | 892 |
| DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
| ENST00000263666 | ENST00000318789 | PDZRN3 | chr3 | 73651505 | - | FOXP1 | chr3 | 71102924 | - | 0.000591994 | 0.999408 |
| ENST00000263666 | ENST00000475937 | PDZRN3 | chr3 | 73651505 | - | FOXP1 | chr3 | 71102924 | - | 0.001850459 | 0.9981495 |
| ENST00000263666 | ENST00000493089 | PDZRN3 | chr3 | 73651505 | - | FOXP1 | chr3 | 71102924 | - | 0.015007825 | 0.98499215 |
| ENST00000308537 | ENST00000318789 | PDZRN3 | chr3 | 73651505 | - | FOXP1 | chr3 | 71102924 | - | 0.000602108 | 0.9993979 |
| ENST00000308537 | ENST00000475937 | PDZRN3 | chr3 | 73651505 | - | FOXP1 | chr3 | 71102924 | - | 0.001935395 | 0.9980646 |
| ENST00000308537 | ENST00000493089 | PDZRN3 | chr3 | 73651505 | - | FOXP1 | chr3 | 71102924 | - | 0.017497685 | 0.98250234 |
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Fusion Amino Acid Sequences |
| For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
| >FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP >64173_64173_1_PDZRN3-FOXP1_PDZRN3_chr3_73651505_ENST00000263666_FOXP1_chr3_71102924_ENST00000318789_length(amino acids)=893AA_BP=310 MAATMGFELDRFDGDVDPDLKCALCHKVLEDPLTTPCGHVFCAGCVLPWVVQEGSCPARCRGRLSAKELNHVLPLKRLILKLDIKCAYAT RGCGRVVKLQQLPEHLERCDFAPARCRHAGCGQVLLRRDVEAHMRDACDARPVGRCQEGCGLPLTHGEQRAGGHCCARALRAHNGALQAR LGALHKALKKEALRAGKREKSLVAQLAAAQLELQMTALRYQKKFTEYSARLDSLSRCVAAPPGGKGEETKSLTLVLHRDSGSLGFNIIGG RPSVDNHDGSSSEGIFVSKIVDSGPAAKEGGLQIHDRIIEVPVSVAMMTPQVITPQQMQQILQQQVLSPQQLQVLLQQQQALMLQQQQLQ EFYKKQQEQLQLQLLQQQHAGKQPKEQQQVATQQLAFQQQLLQMQQLQQQHLLSLQRQGLLTIQPGQPALPLQPLAQGMIPTELQQLWKE VTSAHTAEETTGNNHSSLDLTTTCVSSSAPSKTSLIMNPHASTNGQLSVHTPKRESLSHEEHPHSHPLYGHGVCKWPGCEAVCEDFQSFL KHLNSEHALDDRSTAQCRVQMQVVQQLELQLAKDKERLQAMMTHLHVKSTEPKAAPQPLNLVSSVTLSKSASEASPQSLPHTPTTPTAPL TPVTQGPSVITTTSMHTVGPIRRRYSDKYNVPISSADIAQNQEFYKNAEVRPPFTYASLIRQAILESPEKQLTLNEIYNWFTRMFAYFRR NAATWKNAVRHNLSLHKCFVRVENVKGAVWTVDEVEFQKRRPQKISGNPSLIKNMQSSHAYCTPLNAALQASMAENSIPLYTTASMGNPT -------------------------------------------------------------- >64173_64173_2_PDZRN3-FOXP1_PDZRN3_chr3_73651505_ENST00000263666_FOXP1_chr3_71102924_ENST00000475937_length(amino acids)=893AA_BP=310 MAATMGFELDRFDGDVDPDLKCALCHKVLEDPLTTPCGHVFCAGCVLPWVVQEGSCPARCRGRLSAKELNHVLPLKRLILKLDIKCAYAT RGCGRVVKLQQLPEHLERCDFAPARCRHAGCGQVLLRRDVEAHMRDACDARPVGRCQEGCGLPLTHGEQRAGGHCCARALRAHNGALQAR LGALHKALKKEALRAGKREKSLVAQLAAAQLELQMTALRYQKKFTEYSARLDSLSRCVAAPPGGKGEETKSLTLVLHRDSGSLGFNIIGG RPSVDNHDGSSSEGIFVSKIVDSGPAAKEGGLQIHDRIIEVPVSVAMMTPQVITPQQMQQILQQQVLSPQQLQVLLQQQQALMLQQQQLQ EFYKKQQEQLQLQLLQQQHAGKQPKEQQQVATQQLAFQQQLLQMQQLQQQHLLSLQRQGLLTIQPGQPALPLQPLAQGMIPTELQQLWKE VTSAHTAEETTGNNHSSLDLTTTCVSSSAPSKTSLIMNPHASTNGQLSVHTPKRESLSHEEHPHSHPLYGHGVCKWPGCEAVCEDFQSFL KHLNSEHALDDRSTAQCRVQMQVVQQLELQLAKDKERLQAMMTHLHVKSTEPKAAPQPLNLVSSVTLSKSASEASPQSLPHTPTTPTAPL TPVTQGPSVITTTSMHTVGPIRRRYSDKYNVPISSADIAQNQEFYKNAEVRPPFTYASLIRQAILESPEKQLTLNEIYNWFTRMFAYFRR NAATWKNAVRHNLSLHKCFVRVENVKGAVWTVDEVEFQKRRPQKISGNPSLIKNMQSSHAYCTPLNAALQASMAENSIPLYTTASMGNPT -------------------------------------------------------------- >64173_64173_3_PDZRN3-FOXP1_PDZRN3_chr3_73651505_ENST00000263666_FOXP1_chr3_71102924_ENST00000493089_length(amino acids)=892AA_BP=310 MAATMGFELDRFDGDVDPDLKCALCHKVLEDPLTTPCGHVFCAGCVLPWVVQEGSCPARCRGRLSAKELNHVLPLKRLILKLDIKCAYAT RGCGRVVKLQQLPEHLERCDFAPARCRHAGCGQVLLRRDVEAHMRDACDARPVGRCQEGCGLPLTHGEQRAGGHCCARALRAHNGALQAR LGALHKALKKEALRAGKREKSLVAQLAAAQLELQMTALRYQKKFTEYSARLDSLSRCVAAPPGGKGEETKSLTLVLHRDSGSLGFNIIGG RPSVDNHDGSSSEGIFVSKIVDSGPAAKEGGLQIHDRIIEVPVSVAMMTPQVITPQQMQQILQQQVLSPQQLQVLLQQQQALMLQQQQLQ EFYKKQQEQLQLQLLQQQHAGKQPKEQQQVATQQLAFQQQLLQMQQLQQQHLLSLQRQGLLTIQPGQPALPLQPLAQGMIPTELQQLWKE VTSAHTAEETTGNNHSSLDLTTTCVSSSAPSKTSLIMNPHASTNGQLSVHTPKRESLSHEEHPHSHPLYGHGVCKWPGCEAVCEDFQSFL KHLNSEHALDDRSTAQCRVQMQVVQQLELQLAKDKERLQAMMTHLHVKSTEPKAAPQPLNLVSSVTLSKSASEASPQSLPHTPTTPTAPL TPVTQGPSVITTTSMHTVGPIRRRYSDKYNVPISSDIAQNQEFYKNAEVRPPFTYASLIRQAILESPEKQLTLNEIYNWFTRMFAYFRRN AATWKNAVRHNLSLHKCFVRVENVKGAVWTVDEVEFQKRRPQKISGNPSLIKNMQSSHAYCTPLNAALQASMAENSIPLYTTASMGNPTL -------------------------------------------------------------- >64173_64173_4_PDZRN3-FOXP1_PDZRN3_chr3_73651505_ENST00000308537_FOXP1_chr3_71102924_ENST00000318789_length(amino acids)=893AA_BP=310 MAATMGFELDRFDGDVDPDLKCALCHKVLEDPLTTPCGHVFCAGCVLPWVVQEGSCPARCRGRLSAKELNHVLPLKRLILKLDIKCAYAT RGCGRVVKLQQLPEHLERCDFAPARCRHAGCGQVLLRRDVEAHMRDACDARPVGRCQEGCGLPLTHGEQRAGGHCCARALRAHNGALQAR LGALHKALKKEALRAGKREKSLVAQLAAAQLELQMTALRYQKKFTEYSARLDSLSRCVAAPPGGKGEETKSLTLVLHRDSGSLGFNIIGG RPSVDNHDGSSSEGIFVSKIVDSGPAAKEGGLQIHDRIIEVPVSVAMMTPQVITPQQMQQILQQQVLSPQQLQVLLQQQQALMLQQQQLQ EFYKKQQEQLQLQLLQQQHAGKQPKEQQQVATQQLAFQQQLLQMQQLQQQHLLSLQRQGLLTIQPGQPALPLQPLAQGMIPTELQQLWKE VTSAHTAEETTGNNHSSLDLTTTCVSSSAPSKTSLIMNPHASTNGQLSVHTPKRESLSHEEHPHSHPLYGHGVCKWPGCEAVCEDFQSFL KHLNSEHALDDRSTAQCRVQMQVVQQLELQLAKDKERLQAMMTHLHVKSTEPKAAPQPLNLVSSVTLSKSASEASPQSLPHTPTTPTAPL TPVTQGPSVITTTSMHTVGPIRRRYSDKYNVPISSADIAQNQEFYKNAEVRPPFTYASLIRQAILESPEKQLTLNEIYNWFTRMFAYFRR NAATWKNAVRHNLSLHKCFVRVENVKGAVWTVDEVEFQKRRPQKISGNPSLIKNMQSSHAYCTPLNAALQASMAENSIPLYTTASMGNPT -------------------------------------------------------------- >64173_64173_5_PDZRN3-FOXP1_PDZRN3_chr3_73651505_ENST00000308537_FOXP1_chr3_71102924_ENST00000475937_length(amino acids)=893AA_BP=310 MAATMGFELDRFDGDVDPDLKCALCHKVLEDPLTTPCGHVFCAGCVLPWVVQEGSCPARCRGRLSAKELNHVLPLKRLILKLDIKCAYAT RGCGRVVKLQQLPEHLERCDFAPARCRHAGCGQVLLRRDVEAHMRDACDARPVGRCQEGCGLPLTHGEQRAGGHCCARALRAHNGALQAR LGALHKALKKEALRAGKREKSLVAQLAAAQLELQMTALRYQKKFTEYSARLDSLSRCVAAPPGGKGEETKSLTLVLHRDSGSLGFNIIGG RPSVDNHDGSSSEGIFVSKIVDSGPAAKEGGLQIHDRIIEVPVSVAMMTPQVITPQQMQQILQQQVLSPQQLQVLLQQQQALMLQQQQLQ EFYKKQQEQLQLQLLQQQHAGKQPKEQQQVATQQLAFQQQLLQMQQLQQQHLLSLQRQGLLTIQPGQPALPLQPLAQGMIPTELQQLWKE VTSAHTAEETTGNNHSSLDLTTTCVSSSAPSKTSLIMNPHASTNGQLSVHTPKRESLSHEEHPHSHPLYGHGVCKWPGCEAVCEDFQSFL KHLNSEHALDDRSTAQCRVQMQVVQQLELQLAKDKERLQAMMTHLHVKSTEPKAAPQPLNLVSSVTLSKSASEASPQSLPHTPTTPTAPL TPVTQGPSVITTTSMHTVGPIRRRYSDKYNVPISSADIAQNQEFYKNAEVRPPFTYASLIRQAILESPEKQLTLNEIYNWFTRMFAYFRR NAATWKNAVRHNLSLHKCFVRVENVKGAVWTVDEVEFQKRRPQKISGNPSLIKNMQSSHAYCTPLNAALQASMAENSIPLYTTASMGNPT -------------------------------------------------------------- >64173_64173_6_PDZRN3-FOXP1_PDZRN3_chr3_73651505_ENST00000308537_FOXP1_chr3_71102924_ENST00000493089_length(amino acids)=892AA_BP=310 MAATMGFELDRFDGDVDPDLKCALCHKVLEDPLTTPCGHVFCAGCVLPWVVQEGSCPARCRGRLSAKELNHVLPLKRLILKLDIKCAYAT RGCGRVVKLQQLPEHLERCDFAPARCRHAGCGQVLLRRDVEAHMRDACDARPVGRCQEGCGLPLTHGEQRAGGHCCARALRAHNGALQAR LGALHKALKKEALRAGKREKSLVAQLAAAQLELQMTALRYQKKFTEYSARLDSLSRCVAAPPGGKGEETKSLTLVLHRDSGSLGFNIIGG RPSVDNHDGSSSEGIFVSKIVDSGPAAKEGGLQIHDRIIEVPVSVAMMTPQVITPQQMQQILQQQVLSPQQLQVLLQQQQALMLQQQQLQ EFYKKQQEQLQLQLLQQQHAGKQPKEQQQVATQQLAFQQQLLQMQQLQQQHLLSLQRQGLLTIQPGQPALPLQPLAQGMIPTELQQLWKE VTSAHTAEETTGNNHSSLDLTTTCVSSSAPSKTSLIMNPHASTNGQLSVHTPKRESLSHEEHPHSHPLYGHGVCKWPGCEAVCEDFQSFL KHLNSEHALDDRSTAQCRVQMQVVQQLELQLAKDKERLQAMMTHLHVKSTEPKAAPQPLNLVSSVTLSKSASEASPQSLPHTPTTPTAPL TPVTQGPSVITTTSMHTVGPIRRRYSDKYNVPISSDIAQNQEFYKNAEVRPPFTYASLIRQAILESPEKQLTLNEIYNWFTRMFAYFRRN AATWKNAVRHNLSLHKCFVRVENVKGAVWTVDEVEFQKRRPQKISGNPSLIKNMQSSHAYCTPLNAALQASMAENSIPLYTTASMGNPTL -------------------------------------------------------------- |
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Fusion Protein Functional Features |
| Four levels of functional features of fusion genes Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr3:71026793/chr3:73453546) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
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| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| . | FOXP1 |
| FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes. | FUNCTION: Transcriptional repressor (PubMed:18347093, PubMed:26647308). Can act with CTBP1 to synergistically repress transcription but CTPBP1 is not essential (By similarity). Plays an important role in the specification and differentiation of lung epithelium. Acts cooperatively with FOXP4 to regulate lung secretory epithelial cell fate and regeneration by restricting the goblet cell lineage program; the function may involve regulation of AGR2. Essential transcriptional regulator of B-cell development. Involved in regulation of cardiac muscle cell proliferation. Involved in the columnar organization of spinal motor neurons. Promotes the formation of the lateral motor neuron column (LMC) and the preganglionic motor column (PGC) and is required for respective appropriate motor axon projections. The segment-appropriate generation of spinal chord motor columns requires cooperation with other Hox proteins. Can regulate PITX3 promoter activity; may promote midbrain identity in embryonic stem cell-derived dopamine neurons by regulating PITX3. Negatively regulates the differentiation of T follicular helper cells T(FH)s. Involved in maintenance of hair follicle stem cell quiescence; the function probably involves regulation of FGF18 (By similarity). Represses transcription of various pro-apoptotic genes and cooperates with NF-kappa B-signaling in promoting B-cell expansion by inhibition of caspase-dependent apoptosis (PubMed:25267198). Binds to CSF1R promoter elements and is involved in regulation of monocyte differentiation and macrophage functions; repression of CSF1R in monocytes seems to involve NCOR2 as corepressor (PubMed:15286807, PubMed:18799727, PubMed:18347093). Involved in endothelial cell proliferation, tube formation and migration indicative for a role in angiogenesis; the role in neovascularization seems to implicate suppression of SEMA5B (PubMed:24023716). Can negatively regulate androgen receptor signaling (PubMed:18640093). Acts as a transcriptional activator of the FBXL7 promoter; this activity is regulated by AURKA (PubMed:28218735). {ECO:0000250|UniProtKB:P58462, ECO:0000269|PubMed:15286807, ECO:0000269|PubMed:18640093, ECO:0000269|PubMed:18799727, ECO:0000269|PubMed:24023716, ECO:0000269|PubMed:25267198, ECO:0000269|PubMed:26647308, ECO:0000269|PubMed:28218735, ECO:0000305|PubMed:18347093, ECO:0000305|PubMed:24023716}.; FUNCTION: [Isoform 8]: Involved in transcriptional regulation in embryonic stem cells (ESCs). Stimulates expression of transcription factors that are required for pluripotency and decreases expression of differentiation-associated genes. Has distinct DNA-binding specifities as compared to the canonical form and preferentially binds DNA with the sequence 5'-CGATACAA-3' (or closely related sequences) (PubMed:21924763). Promotes ESC self-renewal and pluripotency (By similarity). {ECO:0000250|UniProtKB:P58462, ECO:0000269|PubMed:21924763}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
| - Retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | PDZRN3 | chr3:73651505 | chr3:71102924 | ENST00000263666 | - | 3 | 10 | 100_158 | 306.0 | 1067.0 | Zinc finger | TRAF-type |
| Hgene | PDZRN3 | chr3:73651505 | chr3:71102924 | ENST00000263666 | - | 3 | 10 | 18_56 | 306.0 | 1067.0 | Zinc finger | RING-type%3B degenerate |
| Hgene | PDZRN3 | chr3:73651505 | chr3:71102924 | ENST00000308537 | - | 3 | 4 | 100_158 | 306.0 | 361.0 | Zinc finger | TRAF-type |
| Hgene | PDZRN3 | chr3:73651505 | chr3:71102924 | ENST00000308537 | - | 3 | 4 | 18_56 | 306.0 | 361.0 | Zinc finger | RING-type%3B degenerate |
| Tgene | FOXP1 | chr3:73651505 | chr3:71102924 | ENST00000318779 | 0 | 7 | 55_230 | 0 | 115.0 | Compositional bias | Note=Gln-rich | |
| Tgene | FOXP1 | chr3:73651505 | chr3:71102924 | ENST00000484350 | 0 | 16 | 55_230 | 0 | 602.0 | Compositional bias | Note=Gln-rich | |
| Tgene | FOXP1 | chr3:73651505 | chr3:71102924 | ENST00000318779 | 0 | 7 | 465_555 | 0 | 115.0 | DNA binding | Fork-head | |
| Tgene | FOXP1 | chr3:73651505 | chr3:71102924 | ENST00000318789 | 6 | 21 | 465_555 | 94.0 | 678.0 | DNA binding | Fork-head | |
| Tgene | FOXP1 | chr3:73651505 | chr3:71102924 | ENST00000475937 | 5 | 20 | 465_555 | 94.0 | 678.0 | DNA binding | Fork-head | |
| Tgene | FOXP1 | chr3:73651505 | chr3:71102924 | ENST00000484350 | 0 | 16 | 465_555 | 0 | 602.0 | DNA binding | Fork-head | |
| Tgene | FOXP1 | chr3:73651505 | chr3:71102924 | ENST00000493089 | 6 | 21 | 465_555 | 94.0 | 677.0 | DNA binding | Fork-head | |
| Tgene | FOXP1 | chr3:73651505 | chr3:71102924 | ENST00000498215 | 2 | 17 | 465_555 | 94.0 | 678.0 | DNA binding | Fork-head | |
| Tgene | FOXP1 | chr3:73651505 | chr3:71102924 | ENST00000318779 | 0 | 7 | 348_369 | 0 | 115.0 | Region | Note=Leucine-zipper | |
| Tgene | FOXP1 | chr3:73651505 | chr3:71102924 | ENST00000318779 | 0 | 7 | 382_386 | 0 | 115.0 | Region | CTBP1-binding | |
| Tgene | FOXP1 | chr3:73651505 | chr3:71102924 | ENST00000318789 | 6 | 21 | 348_369 | 94.0 | 678.0 | Region | Note=Leucine-zipper | |
| Tgene | FOXP1 | chr3:73651505 | chr3:71102924 | ENST00000318789 | 6 | 21 | 382_386 | 94.0 | 678.0 | Region | CTBP1-binding | |
| Tgene | FOXP1 | chr3:73651505 | chr3:71102924 | ENST00000475937 | 5 | 20 | 348_369 | 94.0 | 678.0 | Region | Note=Leucine-zipper | |
| Tgene | FOXP1 | chr3:73651505 | chr3:71102924 | ENST00000475937 | 5 | 20 | 382_386 | 94.0 | 678.0 | Region | CTBP1-binding | |
| Tgene | FOXP1 | chr3:73651505 | chr3:71102924 | ENST00000484350 | 0 | 16 | 348_369 | 0 | 602.0 | Region | Note=Leucine-zipper | |
| Tgene | FOXP1 | chr3:73651505 | chr3:71102924 | ENST00000484350 | 0 | 16 | 382_386 | 0 | 602.0 | Region | CTBP1-binding | |
| Tgene | FOXP1 | chr3:73651505 | chr3:71102924 | ENST00000493089 | 6 | 21 | 348_369 | 94.0 | 677.0 | Region | Note=Leucine-zipper | |
| Tgene | FOXP1 | chr3:73651505 | chr3:71102924 | ENST00000493089 | 6 | 21 | 382_386 | 94.0 | 677.0 | Region | CTBP1-binding | |
| Tgene | FOXP1 | chr3:73651505 | chr3:71102924 | ENST00000498215 | 2 | 17 | 348_369 | 94.0 | 678.0 | Region | Note=Leucine-zipper | |
| Tgene | FOXP1 | chr3:73651505 | chr3:71102924 | ENST00000498215 | 2 | 17 | 382_386 | 94.0 | 678.0 | Region | CTBP1-binding | |
| Tgene | FOXP1 | chr3:73651505 | chr3:71102924 | ENST00000318779 | 0 | 7 | 306_331 | 0 | 115.0 | Zinc finger | Note=C2H2-type | |
| Tgene | FOXP1 | chr3:73651505 | chr3:71102924 | ENST00000318789 | 6 | 21 | 306_331 | 94.0 | 678.0 | Zinc finger | Note=C2H2-type | |
| Tgene | FOXP1 | chr3:73651505 | chr3:71102924 | ENST00000475937 | 5 | 20 | 306_331 | 94.0 | 678.0 | Zinc finger | Note=C2H2-type | |
| Tgene | FOXP1 | chr3:73651505 | chr3:71102924 | ENST00000484350 | 0 | 16 | 306_331 | 0 | 602.0 | Zinc finger | Note=C2H2-type | |
| Tgene | FOXP1 | chr3:73651505 | chr3:71102924 | ENST00000493089 | 6 | 21 | 306_331 | 94.0 | 677.0 | Zinc finger | Note=C2H2-type | |
| Tgene | FOXP1 | chr3:73651505 | chr3:71102924 | ENST00000498215 | 2 | 17 | 306_331 | 94.0 | 678.0 | Zinc finger | Note=C2H2-type |
| - Not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | PDZRN3 | chr3:73651505 | chr3:71102924 | ENST00000263666 | - | 3 | 10 | 679_704 | 306.0 | 1067.0 | Coiled coil | Ontology_term=ECO:0000255 |
| Hgene | PDZRN3 | chr3:73651505 | chr3:71102924 | ENST00000263666 | - | 3 | 10 | 975_1025 | 306.0 | 1067.0 | Coiled coil | Ontology_term=ECO:0000255 |
| Hgene | PDZRN3 | chr3:73651505 | chr3:71102924 | ENST00000308537 | - | 3 | 4 | 679_704 | 306.0 | 361.0 | Coiled coil | Ontology_term=ECO:0000255 |
| Hgene | PDZRN3 | chr3:73651505 | chr3:71102924 | ENST00000308537 | - | 3 | 4 | 975_1025 | 306.0 | 361.0 | Coiled coil | Ontology_term=ECO:0000255 |
| Hgene | PDZRN3 | chr3:73651505 | chr3:71102924 | ENST00000263666 | - | 3 | 10 | 249_339 | 306.0 | 1067.0 | Domain | PDZ 1 |
| Hgene | PDZRN3 | chr3:73651505 | chr3:71102924 | ENST00000263666 | - | 3 | 10 | 419_503 | 306.0 | 1067.0 | Domain | PDZ 2 |
| Hgene | PDZRN3 | chr3:73651505 | chr3:71102924 | ENST00000308537 | - | 3 | 4 | 249_339 | 306.0 | 361.0 | Domain | PDZ 1 |
| Hgene | PDZRN3 | chr3:73651505 | chr3:71102924 | ENST00000308537 | - | 3 | 4 | 419_503 | 306.0 | 361.0 | Domain | PDZ 2 |
| Tgene | FOXP1 | chr3:73651505 | chr3:71102924 | ENST00000318789 | 6 | 21 | 55_230 | 94.0 | 678.0 | Compositional bias | Note=Gln-rich | |
| Tgene | FOXP1 | chr3:73651505 | chr3:71102924 | ENST00000475937 | 5 | 20 | 55_230 | 94.0 | 678.0 | Compositional bias | Note=Gln-rich | |
| Tgene | FOXP1 | chr3:73651505 | chr3:71102924 | ENST00000493089 | 6 | 21 | 55_230 | 94.0 | 677.0 | Compositional bias | Note=Gln-rich | |
| Tgene | FOXP1 | chr3:73651505 | chr3:71102924 | ENST00000498215 | 2 | 17 | 55_230 | 94.0 | 678.0 | Compositional bias | Note=Gln-rich |
Top |
Fusion Protein-Protein Interaction |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in |
| Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160) |
| Gene | PPI interactors |
| Protein-protein interactors based on sequence similarity (STRING) |
| Gene | STRING network |
| PDZRN3 | |
| FOXP1 |
| - Retained interactions in fusion protein (protein functional feature from UniProt). |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost interactions due to fusion (protein functional feature from UniProt). |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
Top |
Related Drugs to PDZRN3-FOXP1 |
| Drugs used for this fusion-positive patient. (Manual curation of PubMed, 04-30-2022 + MyCancerGenome) |
| Hgene | Tgene | Drug | Source | PMID |
Top |
Related Diseases to PDZRN3-FOXP1 |
| Diseases that have this fusion gene. (Manual curation of PubMed, 04-30-2022 + MyCancerGenome) |
| Hgene | Tgene | Disease | Source | PMID |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
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