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level1

	Fusion Gene Summary
	Fusion Gene Sample Information
	Fusion ORF Analysis
	Fusion Amino Acid Sequences
	Fusion Protein Functional Features
	Fusion Protein-Protein Interaction
	Related drugs with this fusion protein
	Related disease with this fusion protein

Fusion Protein:ARID1B-TAX1BP1

Fusion Protein Summary

Fusion gene summary

Fusion partner gene information	Fusion gene name: ARID1B-TAX1BP1
	FusionPDB ID: 6423
	FusionGDB2.0 ID: 6423
		Hgene	Tgene
	Gene symbol	ARID1B	TAX1BP1
	Gene ID	57492	8887
	Gene name	AT-rich interaction domain 1B	Tax1 binding protein 1
	Synonyms	6A3-5\|BAF250B\|BRIGHT\|CSS1\|DAN15\|ELD/OSA1\|MRD12\|OSA2\|P250R	CALCOCO3\|T6BP\|TXBP151
	Cytomap	6q25.3	7p15.2
	Type of gene	protein-coding	protein-coding
	Description	AT-rich interactive domain-containing protein 1BARID domain-containing protein 1BAT rich interactive domain 1B (SWI1-like)BRG1-associated factor 250bBRG1-binding protein ELD/OSA1ELD (eyelid)/OSA protein	tax1-binding protein 1TRAF6-binding proteinTax1 (human T-cell leukemia virus type I) binding protein 1
	Modification date	20200320	20200327
	UniProtAcc	Q8NFD5	.
Ensembl transtripts involved in fusion gene	ENST ids	ENST00000275248, ENST00000346085, ENST00000350026, ENST00000367148, ENST00000478761,	ENST00000396319, ENST00000433216, ENST00000494033, ENST00000265393, ENST00000409980, ENST00000543117,
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)	* DoF score	27 X 18 X 14=6804	22 X 14 X 9=2772
	# samples	31	26
	** MAII score	log2(31/6804*10)=-4.45604302038915 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(26/2772*10)=-3.41434372910876 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)	PubMed: ARID1B [Title/Abstract] AND TAX1BP1 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)	ARID1B(157100605)-TAX1BP1(27809294), # samples:2
Anticipated loss of major functional domain due to fusion event.	ARID1B-TAX1BP1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. ARID1B-TAX1BP1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. ARID1B-TAX1BP1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. ARID1B-TAX1BP1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Fusion gene breakpoints across ARID1B (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across TAX1BP1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

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Fusion Gene Sample Information

Fusion gene information from FusionGDB2.0.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	THCA	TCGA-ET-A39P	ARID1B	chr6	157100605	+	TAX1BP1	chr7	27809294	+

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Fusion ORF Analysis

Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000350026	ARID1B	chr6	157100605	+	ENST00000543117	TAX1BP1	chr7	27809294	+	3598	1543	1	3333	1110
ENST00000350026	ARID1B	chr6	157100605	+	ENST00000265393	TAX1BP1	chr7	27809294	+	3386	1543	1	3333	1110
ENST00000350026	ARID1B	chr6	157100605	+	ENST00000409980	TAX1BP1	chr7	27809294	+	3584	1543	1	3531	1176
ENST00000346085	ARID1B	chr6	157100605	+	ENST00000543117	TAX1BP1	chr7	27809294	+	3598	1543	1	3333	1110
ENST00000346085	ARID1B	chr6	157100605	+	ENST00000265393	TAX1BP1	chr7	27809294	+	3386	1543	1	3333	1110
ENST00000346085	ARID1B	chr6	157100605	+	ENST00000409980	TAX1BP1	chr7	27809294	+	3584	1543	1	3531	1176
ENST00000367148	ARID1B	chr6	157100605	+	ENST00000543117	TAX1BP1	chr7	27809294	+	3597	1542	0	3332	1110
ENST00000367148	ARID1B	chr6	157100605	+	ENST00000265393	TAX1BP1	chr7	27809294	+	3385	1542	0	3332	1110
ENST00000367148	ARID1B	chr6	157100605	+	ENST00000409980	TAX1BP1	chr7	27809294	+	3583	1542	0	3530	1176
ENST00000275248	ARID1B	chr6	157100605	+	ENST00000543117	TAX1BP1	chr7	27809294	+	3575	1520	77	3310	1077
ENST00000275248	ARID1B	chr6	157100605	+	ENST00000265393	TAX1BP1	chr7	27809294	+	3363	1520	77	3310	1077
ENST00000275248	ARID1B	chr6	157100605	+	ENST00000409980	TAX1BP1	chr7	27809294	+	3561	1520	77	3508	1143

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000350026	ENST00000543117	ARID1B	chr6	157100605	+	TAX1BP1	chr7	27809294	+	0.003743245	0.9962567
ENST00000350026	ENST00000265393	ARID1B	chr6	157100605	+	TAX1BP1	chr7	27809294	+	0.005560491	0.9944395
ENST00000350026	ENST00000409980	ARID1B	chr6	157100605	+	TAX1BP1	chr7	27809294	+	0.00484765	0.99515235
ENST00000346085	ENST00000543117	ARID1B	chr6	157100605	+	TAX1BP1	chr7	27809294	+	0.003743245	0.9962567
ENST00000346085	ENST00000265393	ARID1B	chr6	157100605	+	TAX1BP1	chr7	27809294	+	0.005560491	0.9944395
ENST00000346085	ENST00000409980	ARID1B	chr6	157100605	+	TAX1BP1	chr7	27809294	+	0.00484765	0.99515235
ENST00000367148	ENST00000543117	ARID1B	chr6	157100605	+	TAX1BP1	chr7	27809294	+	0.003723958	0.996276
ENST00000367148	ENST00000265393	ARID1B	chr6	157100605	+	TAX1BP1	chr7	27809294	+	0.005532646	0.9944674
ENST00000367148	ENST00000409980	ARID1B	chr6	157100605	+	TAX1BP1	chr7	27809294	+	0.004823087	0.9951769
ENST00000275248	ENST00000543117	ARID1B	chr6	157100605	+	TAX1BP1	chr7	27809294	+	0.004410143	0.99558985
ENST00000275248	ENST00000265393	ARID1B	chr6	157100605	+	TAX1BP1	chr7	27809294	+	0.006611608	0.9933884
ENST00000275248	ENST00000409980	ARID1B	chr6	157100605	+	TAX1BP1	chr7	27809294	+	0.005729562	0.99427044

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Fusion Amino Acid Sequences

For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>6423_6423_1_ARID1B-TAX1BP1_ARID1B_chr6_157100605_ENST00000275248_TAX1BP1_chr7_27809294_ENST00000265393_length(amino acids)=1077AA_BP=271
MSSSSSSSAAAAAASSSSSSGPGSAMETGLLPNHKLKTVGEAPAAPPHQQHHHHHHAHHHHHHAHHLHHHHALQQQLNQFQQQQQQQQQQ
QQQQQQQQHPISNNNSLGGAGGGAPQPGPDMEQPQHGGAKDSAAGGQADPPGPPLLSKPGDEDDAPPKMGEPAGGRYEHPGLGALGTQQP
PVAVPGGGGGPAAVPEFNNYYGSAAPASGGPGGRAGPCFDQHGGQQSPGMGMMHSASAAAAGAPGSMDPLQNSHEGYPNSQCNHYPGYSR
PGAGGGGGGGGGGGGGSGGGGGGGGAGAGGAGAGAVAAAAAAAAAAAGGGGGGGYGGSSAGYGVLSSPRQQGGGMMMGPGGGGAASLSKA
AAGSAAGGFQRFAGQNQHPSGATPTLNQLLTSPSPMMRSYGGSYPEYSSPSAPPPPPSQPQSQAAAAGAAAGGQQAAAGMGLGKDMGAQY
AAASPAWAAAQQRSHPAMSPGTPGPTMGRSQLKIEKTMKEKEELLKLIAVLEKETAQLREQVGRMERELNHEKERCDQLQAEQKGLTEVT
QSLKMENEEFKKRFSDATSKAHQLEEDIVSVTHKAIEKETELDSLKDKLKKAQHEREQLECQLKTEKDEKELYKVHLKNTEIENTKLMSE
VQTLKNLDGNKESVITHFKEEIGRLQLCLAEKENLQRTFLLTTSSKEDTCFLKEQLRKAEEQVQATRQEVVFLAKELSDAVNVRDRTMAD
LHTARLENEKVKKQLADAVAELKLNAMKKDQDKTDTLEHELRREVEDLKLRLQMAADHYKEKFKECQRLQKQINKLSDQSANNNNVFTKK
TGNQQKVNDASVNTDPATSASTVDVKPSPSAAEADFDIVTKGQVCEMTKEIADKTEKYNKCKQLLQDEKAKCNKYADELAKMELKWKEQV
KIAENVKLELAEVQDNYKELKRSLENPAERKMEDGADGAFYPDEIQRPPVRVPSWGLEDNVVCSQPARNFSRPDGLEDSEDSKEDENVPT

--------------------------------------------------------------

>6423_6423_2_ARID1B-TAX1BP1_ARID1B_chr6_157100605_ENST00000275248_TAX1BP1_chr7_27809294_ENST00000409980_length(amino acids)=1143AA_BP=271
MSSSSSSSAAAAAASSSSSSGPGSAMETGLLPNHKLKTVGEAPAAPPHQQHHHHHHAHHHHHHAHHLHHHHALQQQLNQFQQQQQQQQQQ
QQQQQQQQHPISNNNSLGGAGGGAPQPGPDMEQPQHGGAKDSAAGGQADPPGPPLLSKPGDEDDAPPKMGEPAGGRYEHPGLGALGTQQP
PVAVPGGGGGPAAVPEFNNYYGSAAPASGGPGGRAGPCFDQHGGQQSPGMGMMHSASAAAAGAPGSMDPLQNSHEGYPNSQCNHYPGYSR
PGAGGGGGGGGGGGGGSGGGGGGGGAGAGGAGAGAVAAAAAAAAAAAGGGGGGGYGGSSAGYGVLSSPRQQGGGMMMGPGGGGAASLSKA
AAGSAAGGFQRFAGQNQHPSGATPTLNQLLTSPSPMMRSYGGSYPEYSSPSAPPPPPSQPQSQAAAAGAAAGGQQAAAGMGLGKDMGAQY
AAASPAWAAAQQRSHPAMSPGTPGPTMGRSQLKIEKTMKEKEELLKLIAVLEKETAQLREQVGRMERELNHEKERCDQLQAEQKGLTEVT
QSLKMENEEFKKRFSDATSKAHQLEEDIVSVTHKAIEKETELDSLKDKLKKAQHEREQLECQLKTEKDEKELYKVHLKNTEIENTKLMSE
VQTLKNLDGNKESVITHFKEEIGRLQLCLAEKENLQRTFLLTTSSKEDTCFLKEQLRKAEEQVQATRQEVVFLAKELSDAVNVRDRTMAD
LHTARLENEKVKKQLADAVAELKLNAMKKDQDKTDTLEHELRREVEDLKLRLQMAADHYKEKFKECQRLQKQINKLSDQSANNNNVFTKK
TGNQQKVNDASVNTDPATSASTVDVKPSPSAAEADFDIVTKGQVCEMTKEIADKTEKYNKCKQLLQDEKAKCNKYADELAKMELKWKEQV
KIAENVKLELAEVQDNYKLQLAEKDKEISGLISHLENLSREKELKRSLENPAERKMEGQNSQSPQCFKTCSEQNGYVLTLSNAQPVLQYG
NPYASQETRDGADGAFYPDEIQRPPVRVPSWGLEDNVVCSQPARNFSRPDGLEDSEDSKEDENVPTAPDPPSQHLRGHGTGFCFDSSFDV

--------------------------------------------------------------

>6423_6423_3_ARID1B-TAX1BP1_ARID1B_chr6_157100605_ENST00000275248_TAX1BP1_chr7_27809294_ENST00000543117_length(amino acids)=1077AA_BP=271
MSSSSSSSAAAAAASSSSSSGPGSAMETGLLPNHKLKTVGEAPAAPPHQQHHHHHHAHHHHHHAHHLHHHHALQQQLNQFQQQQQQQQQQ
QQQQQQQQHPISNNNSLGGAGGGAPQPGPDMEQPQHGGAKDSAAGGQADPPGPPLLSKPGDEDDAPPKMGEPAGGRYEHPGLGALGTQQP
PVAVPGGGGGPAAVPEFNNYYGSAAPASGGPGGRAGPCFDQHGGQQSPGMGMMHSASAAAAGAPGSMDPLQNSHEGYPNSQCNHYPGYSR
PGAGGGGGGGGGGGGGSGGGGGGGGAGAGGAGAGAVAAAAAAAAAAAGGGGGGGYGGSSAGYGVLSSPRQQGGGMMMGPGGGGAASLSKA
AAGSAAGGFQRFAGQNQHPSGATPTLNQLLTSPSPMMRSYGGSYPEYSSPSAPPPPPSQPQSQAAAAGAAAGGQQAAAGMGLGKDMGAQY
AAASPAWAAAQQRSHPAMSPGTPGPTMGRSQLKIEKTMKEKEELLKLIAVLEKETAQLREQVGRMERELNHEKERCDQLQAEQKGLTEVT
QSLKMENEEFKKRFSDATSKAHQLEEDIVSVTHKAIEKETELDSLKDKLKKAQHEREQLECQLKTEKDEKELYKVHLKNTEIENTKLMSE
VQTLKNLDGNKESVITHFKEEIGRLQLCLAEKENLQRTFLLTTSSKEDTCFLKEQLRKAEEQVQATRQEVVFLAKELSDAVNVRDRTMAD
LHTARLENEKVKKQLADAVAELKLNAMKKDQDKTDTLEHELRREVEDLKLRLQMAADHYKEKFKECQRLQKQINKLSDQSANNNNVFTKK
TGNQQKVNDASVNTDPATSASTVDVKPSPSAAEADFDIVTKGQVCEMTKEIADKTEKYNKCKQLLQDEKAKCNKYADELAKMELKWKEQV
KIAENVKLELAEVQDNYKELKRSLENPAERKMEDGADGAFYPDEIQRPPVRVPSWGLEDNVVCSQPARNFSRPDGLEDSEDSKEDENVPT

--------------------------------------------------------------

>6423_6423_4_ARID1B-TAX1BP1_ARID1B_chr6_157100605_ENST00000346085_TAX1BP1_chr7_27809294_ENST00000265393_length(amino acids)=1110AA_BP=304
MAHNAGAAAAAGTHSAKSGGSEAALKEGGSAAALSSSSSSSAAAAAASSSSSSGPGSAMETGLLPNHKLKTVGEAPAAPPHQQHHHHHHA
HHHHHHAHHLHHHHALQQQLNQFQQQQQQQQQQQQQQQQQQHPISNNNSLGGAGGGAPQPGPDMEQPQHGGAKDSAAGGQADPPGPPLLS
KPGDEDDAPPKMGEPAGGRYEHPGLGALGTQQPPVAVPGGGGGPAAVPEFNNYYGSAAPASGGPGGRAGPCFDQHGGQQSPGMGMMHSAS
AAAAGAPGSMDPLQNSHEGYPNSQCNHYPGYSRPGAGGGGGGGGGGGGGSGGGGGGGGAGAGGAGAGAVAAAAAAAAAAAGGGGGGGYGG
SSAGYGVLSSPRQQGGGMMMGPGGGGAASLSKAAAGSAAGGFQRFAGQNQHPSGATPTLNQLLTSPSPMMRSYGGSYPEYSSPSAPPPPP
SQPQSQAAAAGAAAGGQQAAAGMGLGKDMGAQYAAASPAWAAAQQRSHPAMSPGTPGPTMGRSQLKIEKTMKEKEELLKLIAVLEKETAQ
LREQVGRMERELNHEKERCDQLQAEQKGLTEVTQSLKMENEEFKKRFSDATSKAHQLEEDIVSVTHKAIEKETELDSLKDKLKKAQHERE
QLECQLKTEKDEKELYKVHLKNTEIENTKLMSEVQTLKNLDGNKESVITHFKEEIGRLQLCLAEKENLQRTFLLTTSSKEDTCFLKEQLR
KAEEQVQATRQEVVFLAKELSDAVNVRDRTMADLHTARLENEKVKKQLADAVAELKLNAMKKDQDKTDTLEHELRREVEDLKLRLQMAAD
HYKEKFKECQRLQKQINKLSDQSANNNNVFTKKTGNQQKVNDASVNTDPATSASTVDVKPSPSAAEADFDIVTKGQVCEMTKEIADKTEK
YNKCKQLLQDEKAKCNKYADELAKMELKWKEQVKIAENVKLELAEVQDNYKELKRSLENPAERKMEDGADGAFYPDEIQRPPVRVPSWGL
EDNVVCSQPARNFSRPDGLEDSEDSKEDENVPTAPDPPSQHLRGHGTGFCFDSSFDVHKKCPLCELMFPPNYDQSKFEEHVESHWKVCPM

--------------------------------------------------------------

>6423_6423_5_ARID1B-TAX1BP1_ARID1B_chr6_157100605_ENST00000346085_TAX1BP1_chr7_27809294_ENST00000409980_length(amino acids)=1176AA_BP=304
MAHNAGAAAAAGTHSAKSGGSEAALKEGGSAAALSSSSSSSAAAAAASSSSSSGPGSAMETGLLPNHKLKTVGEAPAAPPHQQHHHHHHA
HHHHHHAHHLHHHHALQQQLNQFQQQQQQQQQQQQQQQQQQHPISNNNSLGGAGGGAPQPGPDMEQPQHGGAKDSAAGGQADPPGPPLLS
KPGDEDDAPPKMGEPAGGRYEHPGLGALGTQQPPVAVPGGGGGPAAVPEFNNYYGSAAPASGGPGGRAGPCFDQHGGQQSPGMGMMHSAS
AAAAGAPGSMDPLQNSHEGYPNSQCNHYPGYSRPGAGGGGGGGGGGGGGSGGGGGGGGAGAGGAGAGAVAAAAAAAAAAAGGGGGGGYGG
SSAGYGVLSSPRQQGGGMMMGPGGGGAASLSKAAAGSAAGGFQRFAGQNQHPSGATPTLNQLLTSPSPMMRSYGGSYPEYSSPSAPPPPP
SQPQSQAAAAGAAAGGQQAAAGMGLGKDMGAQYAAASPAWAAAQQRSHPAMSPGTPGPTMGRSQLKIEKTMKEKEELLKLIAVLEKETAQ
LREQVGRMERELNHEKERCDQLQAEQKGLTEVTQSLKMENEEFKKRFSDATSKAHQLEEDIVSVTHKAIEKETELDSLKDKLKKAQHERE
QLECQLKTEKDEKELYKVHLKNTEIENTKLMSEVQTLKNLDGNKESVITHFKEEIGRLQLCLAEKENLQRTFLLTTSSKEDTCFLKEQLR
KAEEQVQATRQEVVFLAKELSDAVNVRDRTMADLHTARLENEKVKKQLADAVAELKLNAMKKDQDKTDTLEHELRREVEDLKLRLQMAAD
HYKEKFKECQRLQKQINKLSDQSANNNNVFTKKTGNQQKVNDASVNTDPATSASTVDVKPSPSAAEADFDIVTKGQVCEMTKEIADKTEK
YNKCKQLLQDEKAKCNKYADELAKMELKWKEQVKIAENVKLELAEVQDNYKLQLAEKDKEISGLISHLENLSREKELKRSLENPAERKME
GQNSQSPQCFKTCSEQNGYVLTLSNAQPVLQYGNPYASQETRDGADGAFYPDEIQRPPVRVPSWGLEDNVVCSQPARNFSRPDGLEDSED
SKEDENVPTAPDPPSQHLRGHGTGFCFDSSFDVHKKCPLCELMFPPNYDQSKFEEHVESHWKVCPMCSEQFPPDYDQQVFERHVQTHFDQ

--------------------------------------------------------------

>6423_6423_6_ARID1B-TAX1BP1_ARID1B_chr6_157100605_ENST00000346085_TAX1BP1_chr7_27809294_ENST00000543117_length(amino acids)=1110AA_BP=304
MAHNAGAAAAAGTHSAKSGGSEAALKEGGSAAALSSSSSSSAAAAAASSSSSSGPGSAMETGLLPNHKLKTVGEAPAAPPHQQHHHHHHA
HHHHHHAHHLHHHHALQQQLNQFQQQQQQQQQQQQQQQQQQHPISNNNSLGGAGGGAPQPGPDMEQPQHGGAKDSAAGGQADPPGPPLLS
KPGDEDDAPPKMGEPAGGRYEHPGLGALGTQQPPVAVPGGGGGPAAVPEFNNYYGSAAPASGGPGGRAGPCFDQHGGQQSPGMGMMHSAS
AAAAGAPGSMDPLQNSHEGYPNSQCNHYPGYSRPGAGGGGGGGGGGGGGSGGGGGGGGAGAGGAGAGAVAAAAAAAAAAAGGGGGGGYGG
SSAGYGVLSSPRQQGGGMMMGPGGGGAASLSKAAAGSAAGGFQRFAGQNQHPSGATPTLNQLLTSPSPMMRSYGGSYPEYSSPSAPPPPP
SQPQSQAAAAGAAAGGQQAAAGMGLGKDMGAQYAAASPAWAAAQQRSHPAMSPGTPGPTMGRSQLKIEKTMKEKEELLKLIAVLEKETAQ
LREQVGRMERELNHEKERCDQLQAEQKGLTEVTQSLKMENEEFKKRFSDATSKAHQLEEDIVSVTHKAIEKETELDSLKDKLKKAQHERE
QLECQLKTEKDEKELYKVHLKNTEIENTKLMSEVQTLKNLDGNKESVITHFKEEIGRLQLCLAEKENLQRTFLLTTSSKEDTCFLKEQLR
KAEEQVQATRQEVVFLAKELSDAVNVRDRTMADLHTARLENEKVKKQLADAVAELKLNAMKKDQDKTDTLEHELRREVEDLKLRLQMAAD
HYKEKFKECQRLQKQINKLSDQSANNNNVFTKKTGNQQKVNDASVNTDPATSASTVDVKPSPSAAEADFDIVTKGQVCEMTKEIADKTEK
YNKCKQLLQDEKAKCNKYADELAKMELKWKEQVKIAENVKLELAEVQDNYKELKRSLENPAERKMEDGADGAFYPDEIQRPPVRVPSWGL
EDNVVCSQPARNFSRPDGLEDSEDSKEDENVPTAPDPPSQHLRGHGTGFCFDSSFDVHKKCPLCELMFPPNYDQSKFEEHVESHWKVCPM

--------------------------------------------------------------

>6423_6423_7_ARID1B-TAX1BP1_ARID1B_chr6_157100605_ENST00000350026_TAX1BP1_chr7_27809294_ENST00000265393_length(amino acids)=1110AA_BP=304
MAHNAGAAAAAGTHSAKSGGSEAALKEGGSAAALSSSSSSSAAAAAASSSSSSGPGSAMETGLLPNHKLKTVGEAPAAPPHQQHHHHHHA
HHHHHHAHHLHHHHALQQQLNQFQQQQQQQQQQQQQQQQQQHPISNNNSLGGAGGGAPQPGPDMEQPQHGGAKDSAAGGQADPPGPPLLS
KPGDEDDAPPKMGEPAGGRYEHPGLGALGTQQPPVAVPGGGGGPAAVPEFNNYYGSAAPASGGPGGRAGPCFDQHGGQQSPGMGMMHSAS
AAAAGAPGSMDPLQNSHEGYPNSQCNHYPGYSRPGAGGGGGGGGGGGGGSGGGGGGGGAGAGGAGAGAVAAAAAAAAAAAGGGGGGGYGG
SSAGYGVLSSPRQQGGGMMMGPGGGGAASLSKAAAGSAAGGFQRFAGQNQHPSGATPTLNQLLTSPSPMMRSYGGSYPEYSSPSAPPPPP
SQPQSQAAAAGAAAGGQQAAAGMGLGKDMGAQYAAASPAWAAAQQRSHPAMSPGTPGPTMGRSQLKIEKTMKEKEELLKLIAVLEKETAQ
LREQVGRMERELNHEKERCDQLQAEQKGLTEVTQSLKMENEEFKKRFSDATSKAHQLEEDIVSVTHKAIEKETELDSLKDKLKKAQHERE
QLECQLKTEKDEKELYKVHLKNTEIENTKLMSEVQTLKNLDGNKESVITHFKEEIGRLQLCLAEKENLQRTFLLTTSSKEDTCFLKEQLR
KAEEQVQATRQEVVFLAKELSDAVNVRDRTMADLHTARLENEKVKKQLADAVAELKLNAMKKDQDKTDTLEHELRREVEDLKLRLQMAAD
HYKEKFKECQRLQKQINKLSDQSANNNNVFTKKTGNQQKVNDASVNTDPATSASTVDVKPSPSAAEADFDIVTKGQVCEMTKEIADKTEK
YNKCKQLLQDEKAKCNKYADELAKMELKWKEQVKIAENVKLELAEVQDNYKELKRSLENPAERKMEDGADGAFYPDEIQRPPVRVPSWGL
EDNVVCSQPARNFSRPDGLEDSEDSKEDENVPTAPDPPSQHLRGHGTGFCFDSSFDVHKKCPLCELMFPPNYDQSKFEEHVESHWKVCPM

--------------------------------------------------------------

>6423_6423_8_ARID1B-TAX1BP1_ARID1B_chr6_157100605_ENST00000350026_TAX1BP1_chr7_27809294_ENST00000409980_length(amino acids)=1176AA_BP=304
MAHNAGAAAAAGTHSAKSGGSEAALKEGGSAAALSSSSSSSAAAAAASSSSSSGPGSAMETGLLPNHKLKTVGEAPAAPPHQQHHHHHHA
HHHHHHAHHLHHHHALQQQLNQFQQQQQQQQQQQQQQQQQQHPISNNNSLGGAGGGAPQPGPDMEQPQHGGAKDSAAGGQADPPGPPLLS
KPGDEDDAPPKMGEPAGGRYEHPGLGALGTQQPPVAVPGGGGGPAAVPEFNNYYGSAAPASGGPGGRAGPCFDQHGGQQSPGMGMMHSAS
AAAAGAPGSMDPLQNSHEGYPNSQCNHYPGYSRPGAGGGGGGGGGGGGGSGGGGGGGGAGAGGAGAGAVAAAAAAAAAAAGGGGGGGYGG
SSAGYGVLSSPRQQGGGMMMGPGGGGAASLSKAAAGSAAGGFQRFAGQNQHPSGATPTLNQLLTSPSPMMRSYGGSYPEYSSPSAPPPPP
SQPQSQAAAAGAAAGGQQAAAGMGLGKDMGAQYAAASPAWAAAQQRSHPAMSPGTPGPTMGRSQLKIEKTMKEKEELLKLIAVLEKETAQ
LREQVGRMERELNHEKERCDQLQAEQKGLTEVTQSLKMENEEFKKRFSDATSKAHQLEEDIVSVTHKAIEKETELDSLKDKLKKAQHERE
QLECQLKTEKDEKELYKVHLKNTEIENTKLMSEVQTLKNLDGNKESVITHFKEEIGRLQLCLAEKENLQRTFLLTTSSKEDTCFLKEQLR
KAEEQVQATRQEVVFLAKELSDAVNVRDRTMADLHTARLENEKVKKQLADAVAELKLNAMKKDQDKTDTLEHELRREVEDLKLRLQMAAD
HYKEKFKECQRLQKQINKLSDQSANNNNVFTKKTGNQQKVNDASVNTDPATSASTVDVKPSPSAAEADFDIVTKGQVCEMTKEIADKTEK
YNKCKQLLQDEKAKCNKYADELAKMELKWKEQVKIAENVKLELAEVQDNYKLQLAEKDKEISGLISHLENLSREKELKRSLENPAERKME
GQNSQSPQCFKTCSEQNGYVLTLSNAQPVLQYGNPYASQETRDGADGAFYPDEIQRPPVRVPSWGLEDNVVCSQPARNFSRPDGLEDSED
SKEDENVPTAPDPPSQHLRGHGTGFCFDSSFDVHKKCPLCELMFPPNYDQSKFEEHVESHWKVCPMCSEQFPPDYDQQVFERHVQTHFDQ

--------------------------------------------------------------

>6423_6423_9_ARID1B-TAX1BP1_ARID1B_chr6_157100605_ENST00000350026_TAX1BP1_chr7_27809294_ENST00000543117_length(amino acids)=1110AA_BP=304
MAHNAGAAAAAGTHSAKSGGSEAALKEGGSAAALSSSSSSSAAAAAASSSSSSGPGSAMETGLLPNHKLKTVGEAPAAPPHQQHHHHHHA
HHHHHHAHHLHHHHALQQQLNQFQQQQQQQQQQQQQQQQQQHPISNNNSLGGAGGGAPQPGPDMEQPQHGGAKDSAAGGQADPPGPPLLS
KPGDEDDAPPKMGEPAGGRYEHPGLGALGTQQPPVAVPGGGGGPAAVPEFNNYYGSAAPASGGPGGRAGPCFDQHGGQQSPGMGMMHSAS
AAAAGAPGSMDPLQNSHEGYPNSQCNHYPGYSRPGAGGGGGGGGGGGGGSGGGGGGGGAGAGGAGAGAVAAAAAAAAAAAGGGGGGGYGG
SSAGYGVLSSPRQQGGGMMMGPGGGGAASLSKAAAGSAAGGFQRFAGQNQHPSGATPTLNQLLTSPSPMMRSYGGSYPEYSSPSAPPPPP
SQPQSQAAAAGAAAGGQQAAAGMGLGKDMGAQYAAASPAWAAAQQRSHPAMSPGTPGPTMGRSQLKIEKTMKEKEELLKLIAVLEKETAQ
LREQVGRMERELNHEKERCDQLQAEQKGLTEVTQSLKMENEEFKKRFSDATSKAHQLEEDIVSVTHKAIEKETELDSLKDKLKKAQHERE
QLECQLKTEKDEKELYKVHLKNTEIENTKLMSEVQTLKNLDGNKESVITHFKEEIGRLQLCLAEKENLQRTFLLTTSSKEDTCFLKEQLR
KAEEQVQATRQEVVFLAKELSDAVNVRDRTMADLHTARLENEKVKKQLADAVAELKLNAMKKDQDKTDTLEHELRREVEDLKLRLQMAAD
HYKEKFKECQRLQKQINKLSDQSANNNNVFTKKTGNQQKVNDASVNTDPATSASTVDVKPSPSAAEADFDIVTKGQVCEMTKEIADKTEK
YNKCKQLLQDEKAKCNKYADELAKMELKWKEQVKIAENVKLELAEVQDNYKELKRSLENPAERKMEDGADGAFYPDEIQRPPVRVPSWGL
EDNVVCSQPARNFSRPDGLEDSEDSKEDENVPTAPDPPSQHLRGHGTGFCFDSSFDVHKKCPLCELMFPPNYDQSKFEEHVESHWKVCPM

--------------------------------------------------------------

>6423_6423_10_ARID1B-TAX1BP1_ARID1B_chr6_157100605_ENST00000367148_TAX1BP1_chr7_27809294_ENST00000265393_length(amino acids)=1110AA_BP=304
MAHNAGAAAAAGTHSAKSGGSEAALKEGGSAAALSSSSSSSAAAAAASSSSSSGPGSAMETGLLPNHKLKTVGEAPAAPPHQQHHHHHHA
HHHHHHAHHLHHHHALQQQLNQFQQQQQQQQQQQQQQQQQQHPISNNNSLGGAGGGAPQPGPDMEQPQHGGAKDSAAGGQADPPGPPLLS
KPGDEDDAPPKMGEPAGGRYEHPGLGALGTQQPPVAVPGGGGGPAAVPEFNNYYGSAAPASGGPGGRAGPCFDQHGGQQSPGMGMMHSAS
AAAAGAPGSMDPLQNSHEGYPNSQCNHYPGYSRPGAGGGGGGGGGGGGGSGGGGGGGGAGAGGAGAGAVAAAAAAAAAAAGGGGGGGYGG
SSAGYGVLSSPRQQGGGMMMGPGGGGAASLSKAAAGSAAGGFQRFAGQNQHPSGATPTLNQLLTSPSPMMRSYGGSYPEYSSPSAPPPPP
SQPQSQAAAAGAAAGGQQAAAGMGLGKDMGAQYAAASPAWAAAQQRSHPAMSPGTPGPTMGRSQLKIEKTMKEKEELLKLIAVLEKETAQ
LREQVGRMERELNHEKERCDQLQAEQKGLTEVTQSLKMENEEFKKRFSDATSKAHQLEEDIVSVTHKAIEKETELDSLKDKLKKAQHERE
QLECQLKTEKDEKELYKVHLKNTEIENTKLMSEVQTLKNLDGNKESVITHFKEEIGRLQLCLAEKENLQRTFLLTTSSKEDTCFLKEQLR
KAEEQVQATRQEVVFLAKELSDAVNVRDRTMADLHTARLENEKVKKQLADAVAELKLNAMKKDQDKTDTLEHELRREVEDLKLRLQMAAD
HYKEKFKECQRLQKQINKLSDQSANNNNVFTKKTGNQQKVNDASVNTDPATSASTVDVKPSPSAAEADFDIVTKGQVCEMTKEIADKTEK
YNKCKQLLQDEKAKCNKYADELAKMELKWKEQVKIAENVKLELAEVQDNYKELKRSLENPAERKMEDGADGAFYPDEIQRPPVRVPSWGL
EDNVVCSQPARNFSRPDGLEDSEDSKEDENVPTAPDPPSQHLRGHGTGFCFDSSFDVHKKCPLCELMFPPNYDQSKFEEHVESHWKVCPM

--------------------------------------------------------------

>6423_6423_11_ARID1B-TAX1BP1_ARID1B_chr6_157100605_ENST00000367148_TAX1BP1_chr7_27809294_ENST00000409980_length(amino acids)=1176AA_BP=304
MAHNAGAAAAAGTHSAKSGGSEAALKEGGSAAALSSSSSSSAAAAAASSSSSSGPGSAMETGLLPNHKLKTVGEAPAAPPHQQHHHHHHA
HHHHHHAHHLHHHHALQQQLNQFQQQQQQQQQQQQQQQQQQHPISNNNSLGGAGGGAPQPGPDMEQPQHGGAKDSAAGGQADPPGPPLLS
KPGDEDDAPPKMGEPAGGRYEHPGLGALGTQQPPVAVPGGGGGPAAVPEFNNYYGSAAPASGGPGGRAGPCFDQHGGQQSPGMGMMHSAS
AAAAGAPGSMDPLQNSHEGYPNSQCNHYPGYSRPGAGGGGGGGGGGGGGSGGGGGGGGAGAGGAGAGAVAAAAAAAAAAAGGGGGGGYGG
SSAGYGVLSSPRQQGGGMMMGPGGGGAASLSKAAAGSAAGGFQRFAGQNQHPSGATPTLNQLLTSPSPMMRSYGGSYPEYSSPSAPPPPP
SQPQSQAAAAGAAAGGQQAAAGMGLGKDMGAQYAAASPAWAAAQQRSHPAMSPGTPGPTMGRSQLKIEKTMKEKEELLKLIAVLEKETAQ
LREQVGRMERELNHEKERCDQLQAEQKGLTEVTQSLKMENEEFKKRFSDATSKAHQLEEDIVSVTHKAIEKETELDSLKDKLKKAQHERE
QLECQLKTEKDEKELYKVHLKNTEIENTKLMSEVQTLKNLDGNKESVITHFKEEIGRLQLCLAEKENLQRTFLLTTSSKEDTCFLKEQLR
KAEEQVQATRQEVVFLAKELSDAVNVRDRTMADLHTARLENEKVKKQLADAVAELKLNAMKKDQDKTDTLEHELRREVEDLKLRLQMAAD
HYKEKFKECQRLQKQINKLSDQSANNNNVFTKKTGNQQKVNDASVNTDPATSASTVDVKPSPSAAEADFDIVTKGQVCEMTKEIADKTEK
YNKCKQLLQDEKAKCNKYADELAKMELKWKEQVKIAENVKLELAEVQDNYKLQLAEKDKEISGLISHLENLSREKELKRSLENPAERKME
GQNSQSPQCFKTCSEQNGYVLTLSNAQPVLQYGNPYASQETRDGADGAFYPDEIQRPPVRVPSWGLEDNVVCSQPARNFSRPDGLEDSED
SKEDENVPTAPDPPSQHLRGHGTGFCFDSSFDVHKKCPLCELMFPPNYDQSKFEEHVESHWKVCPMCSEQFPPDYDQQVFERHVQTHFDQ

--------------------------------------------------------------

>6423_6423_12_ARID1B-TAX1BP1_ARID1B_chr6_157100605_ENST00000367148_TAX1BP1_chr7_27809294_ENST00000543117_length(amino acids)=1110AA_BP=304
MAHNAGAAAAAGTHSAKSGGSEAALKEGGSAAALSSSSSSSAAAAAASSSSSSGPGSAMETGLLPNHKLKTVGEAPAAPPHQQHHHHHHA
HHHHHHAHHLHHHHALQQQLNQFQQQQQQQQQQQQQQQQQQHPISNNNSLGGAGGGAPQPGPDMEQPQHGGAKDSAAGGQADPPGPPLLS
KPGDEDDAPPKMGEPAGGRYEHPGLGALGTQQPPVAVPGGGGGPAAVPEFNNYYGSAAPASGGPGGRAGPCFDQHGGQQSPGMGMMHSAS
AAAAGAPGSMDPLQNSHEGYPNSQCNHYPGYSRPGAGGGGGGGGGGGGGSGGGGGGGGAGAGGAGAGAVAAAAAAAAAAAGGGGGGGYGG
SSAGYGVLSSPRQQGGGMMMGPGGGGAASLSKAAAGSAAGGFQRFAGQNQHPSGATPTLNQLLTSPSPMMRSYGGSYPEYSSPSAPPPPP
SQPQSQAAAAGAAAGGQQAAAGMGLGKDMGAQYAAASPAWAAAQQRSHPAMSPGTPGPTMGRSQLKIEKTMKEKEELLKLIAVLEKETAQ
LREQVGRMERELNHEKERCDQLQAEQKGLTEVTQSLKMENEEFKKRFSDATSKAHQLEEDIVSVTHKAIEKETELDSLKDKLKKAQHERE
QLECQLKTEKDEKELYKVHLKNTEIENTKLMSEVQTLKNLDGNKESVITHFKEEIGRLQLCLAEKENLQRTFLLTTSSKEDTCFLKEQLR
KAEEQVQATRQEVVFLAKELSDAVNVRDRTMADLHTARLENEKVKKQLADAVAELKLNAMKKDQDKTDTLEHELRREVEDLKLRLQMAAD
HYKEKFKECQRLQKQINKLSDQSANNNNVFTKKTGNQQKVNDASVNTDPATSASTVDVKPSPSAAEADFDIVTKGQVCEMTKEIADKTEK
YNKCKQLLQDEKAKCNKYADELAKMELKWKEQVKIAENVKLELAEVQDNYKELKRSLENPAERKMEDGADGAFYPDEIQRPPVRVPSWGL
EDNVVCSQPARNFSRPDGLEDSEDSKEDENVPTAPDPPSQHLRGHGTGFCFDSSFDVHKKCPLCELMFPPNYDQSKFEEHVESHWKVCPM

--------------------------------------------------------------

Top

Fusion Protein Functional Features

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr6:157100605/chr7:27809294)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
ARID1B Q8NFD5	.
FUNCTION: Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth (By similarity). Binds DNA non-specifically (PubMed:14982958, PubMed:15170388). {ECO:0000250\|UniProtKB:E9Q4N7, ECO:0000269\|PubMed:14982958, ECO:0000269\|PubMed:15170388, ECO:0000303\|PubMed:12672490, ECO:0000303\|PubMed:22952240, ECO:0000303\|PubMed:26601204}.	FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
* Minus value of BPloci means that the break pointn is located before the CDS.

- Retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

ARID1B

chr6:157100605

chr7:27809294

ENST00000346085

107_131

514.0

2250.0

Compositional bias

Note=Gln-rich

Hgene

ARID1B

chr6:157100605

chr7:27809294

ENST00000346085

114_131

514.0

2250.0

Compositional bias

Note=Poly-Gln

Hgene

ARID1B

chr6:157100605

chr7:27809294

ENST00000346085

141_401

514.0

2250.0

Compositional bias

Note=Gly-rich

Hgene

ARID1B

chr6:157100605

chr7:27809294

ENST00000346085

2_47

514.0

2250.0

Compositional bias

Note=Ala-rich

Hgene

ARID1B

chr6:157100605

chr7:27809294

ENST00000346085

329_493

514.0

2250.0

Compositional bias

Note=Ala-rich

Hgene

ARID1B

chr6:157100605

chr7:27809294

ENST00000346085

35_57

514.0

2250.0

Compositional bias

Note=Ser-rich

Hgene

ARID1B

chr6:157100605

chr7:27809294

ENST00000346085

81_104

514.0

2250.0

Compositional bias

Note=His-rich

Hgene

ARID1B

chr6:157100605

chr7:27809294

ENST00000350026

107_131

514.0

2237.0

Compositional bias

Note=Gln-rich

Hgene

ARID1B

chr6:157100605

chr7:27809294

ENST00000350026

114_131

514.0

2237.0

Compositional bias

Note=Poly-Gln

Hgene

ARID1B

chr6:157100605

chr7:27809294

ENST00000350026

141_401

514.0

2237.0

Compositional bias

Note=Gly-rich

Hgene

ARID1B

chr6:157100605

chr7:27809294

ENST00000350026

2_47

514.0

2237.0

Compositional bias

Note=Ala-rich

Hgene

ARID1B

chr6:157100605

chr7:27809294

ENST00000350026

329_493

514.0

2237.0

Compositional bias

Note=Ala-rich

Hgene

ARID1B

chr6:157100605

chr7:27809294

ENST00000350026

35_57

514.0

2237.0

Compositional bias

Note=Ser-rich

Hgene

ARID1B

chr6:157100605

chr7:27809294

ENST00000350026

81_104

514.0

2237.0

Compositional bias

Note=His-rich

Hgene

ARID1B

chr6:157100605

chr7:27809294

ENST00000367148

107_131

514.0

2290.0

Compositional bias

Note=Gln-rich

Hgene

ARID1B

chr6:157100605

chr7:27809294

ENST00000367148

114_131

514.0

2290.0

Compositional bias

Note=Poly-Gln

Hgene

ARID1B

chr6:157100605

chr7:27809294

ENST00000367148

141_401

514.0

2290.0

Compositional bias

Note=Gly-rich

Hgene

ARID1B

chr6:157100605

chr7:27809294

ENST00000367148

2_47

514.0

2290.0

Compositional bias

Note=Ala-rich

Hgene

ARID1B

chr6:157100605

chr7:27809294

ENST00000367148

329_493

514.0

2290.0

Compositional bias

Note=Ala-rich

Hgene

ARID1B

chr6:157100605

chr7:27809294

ENST00000367148

35_57

514.0

2290.0

Compositional bias

Note=Ser-rich

Hgene

ARID1B

chr6:157100605

chr7:27809294

ENST00000367148

81_104

514.0

2290.0

Compositional bias

Note=His-rich

Hgene

ARID1B

chr6:157100605

chr7:27809294

ENST00000346085

419_423

514.0

2250.0

Motif

Note=LXXLL

Hgene

ARID1B

chr6:157100605

chr7:27809294

ENST00000350026

419_423

514.0

2237.0

Motif

Note=LXXLL

Hgene

ARID1B

chr6:157100605

chr7:27809294

ENST00000367148

419_423

514.0

2290.0

Motif

Note=LXXLL

Tgene

TAX1BP1

chr6:157100605

chr7:27809294

ENST00000433216

144_599

591.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

TAX1BP1

chr6:157100605

chr7:27809294

ENST00000265393

320_420

151.0

748.0

Region

Note=Oligomerization

Tgene

TAX1BP1

chr6:157100605

chr7:27809294

ENST00000396319

320_420

151.0

790.0

Region

Note=Oligomerization

Tgene

TAX1BP1

chr6:157100605

chr7:27809294

ENST00000433216

320_420

591.0

Region

Note=Oligomerization

Tgene

TAX1BP1

chr6:157100605

chr7:27809294

ENST00000543117

320_420

151.0

748.0

Region

Note=Oligomerization

Tgene

TAX1BP1

chr6:157100605

chr7:27809294

ENST00000265393

727_753

151.0

748.0

Zinc finger

UBZ1-type 1

Tgene

TAX1BP1

chr6:157100605

chr7:27809294

ENST00000265393

754_780

151.0

748.0

Zinc finger

UBZ1-type 2

Tgene

TAX1BP1

chr6:157100605

chr7:27809294

ENST00000396319

727_753

151.0

790.0

Zinc finger

UBZ1-type 1

Tgene

TAX1BP1

chr6:157100605

chr7:27809294

ENST00000396319

754_780

151.0

790.0

Zinc finger

UBZ1-type 2

Tgene

TAX1BP1

chr6:157100605

chr7:27809294

ENST00000433216

727_753

591.0

Zinc finger

UBZ1-type 1

Tgene

TAX1BP1

chr6:157100605

chr7:27809294

ENST00000433216

754_780

591.0

Zinc finger

UBZ1-type 2

Tgene

TAX1BP1

chr6:157100605

chr7:27809294

ENST00000543117

727_753

151.0

748.0

Zinc finger

UBZ1-type 1

Tgene

TAX1BP1

chr6:157100605

chr7:27809294

ENST00000543117

754_780

151.0

748.0

Zinc finger

UBZ1-type 2

- Not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

ARID1B

chr6:157100605

chr7:27809294

ENST00000346085

1034_1037

514.0

2250.0

Compositional bias

Note=Poly-Ser

Hgene

ARID1B

chr6:157100605

chr7:27809294

ENST00000346085

1441_1444

514.0

2250.0

Compositional bias

Note=Poly-Ser

Hgene

ARID1B

chr6:157100605

chr7:27809294

ENST00000346085

1459_1597

514.0

2250.0

Compositional bias

Note=Pro-rich

Hgene

ARID1B

chr6:157100605

chr7:27809294

ENST00000346085

1833_1836

514.0

2250.0

Compositional bias

Note=Poly-Pro

Hgene

ARID1B

chr6:157100605

chr7:27809294

ENST00000346085

574_633

514.0

2250.0

Compositional bias

Note=Gln-rich

Hgene

ARID1B

chr6:157100605

chr7:27809294

ENST00000346085

684_771

514.0

2250.0

Compositional bias

Note=Ser-rich

Hgene

ARID1B

chr6:157100605

chr7:27809294

ENST00000346085

932_935

514.0

2250.0

Compositional bias

Note=Poly-Ala

Hgene

ARID1B

chr6:157100605

chr7:27809294

ENST00000350026

1034_1037

514.0

2237.0

Compositional bias

Note=Poly-Ser

Hgene

ARID1B

chr6:157100605

chr7:27809294

ENST00000350026

1441_1444

514.0

2237.0

Compositional bias

Note=Poly-Ser

Hgene

ARID1B

chr6:157100605

chr7:27809294

ENST00000350026

1459_1597

514.0

2237.0

Compositional bias

Note=Pro-rich

Hgene

ARID1B

chr6:157100605

chr7:27809294

ENST00000350026

1833_1836

514.0

2237.0

Compositional bias

Note=Poly-Pro

Hgene

ARID1B

chr6:157100605

chr7:27809294

ENST00000350026

574_633

514.0

2237.0

Compositional bias

Note=Gln-rich

Hgene

ARID1B

chr6:157100605

chr7:27809294

ENST00000350026

684_771

514.0

2237.0

Compositional bias

Note=Ser-rich

Hgene

ARID1B

chr6:157100605

chr7:27809294

ENST00000350026

932_935

514.0

2237.0

Compositional bias

Note=Poly-Ala

Hgene

ARID1B

chr6:157100605

chr7:27809294

ENST00000367148

1034_1037

514.0

2290.0

Compositional bias

Note=Poly-Ser

Hgene

ARID1B

chr6:157100605

chr7:27809294

ENST00000367148

1441_1444

514.0

2290.0

Compositional bias

Note=Poly-Ser

Hgene

ARID1B

chr6:157100605

chr7:27809294

ENST00000367148

1459_1597

514.0

2290.0

Compositional bias

Note=Pro-rich

Hgene

ARID1B

chr6:157100605

chr7:27809294

ENST00000367148

1833_1836

514.0

2290.0

Compositional bias

Note=Poly-Pro

Hgene

ARID1B

chr6:157100605

chr7:27809294

ENST00000367148

574_633

514.0

2290.0

Compositional bias

Note=Gln-rich

Hgene

ARID1B

chr6:157100605

chr7:27809294

ENST00000367148

684_771

514.0

2290.0

Compositional bias

Note=Ser-rich

Hgene

ARID1B

chr6:157100605

chr7:27809294

ENST00000367148

932_935

514.0

2290.0

Compositional bias

Note=Poly-Ala

Hgene

ARID1B

chr6:157100605

chr7:27809294

ENST00000346085

1053_1144

514.0

2250.0

Domain

ARID

Hgene

ARID1B

chr6:157100605

chr7:27809294

ENST00000350026

1053_1144

514.0

2237.0

Domain

ARID

Hgene

ARID1B

chr6:157100605

chr7:27809294

ENST00000367148

1053_1144

514.0

2290.0

Domain

ARID

Hgene

ARID1B

chr6:157100605

chr7:27809294

ENST00000346085

1358_1377

514.0

2250.0

Motif

Nuclear localization signal

Hgene

ARID1B

chr6:157100605

chr7:27809294

ENST00000346085

2036_2040

514.0

2250.0

Motif

Note=LXXLL

Hgene

ARID1B

chr6:157100605

chr7:27809294

ENST00000350026

1358_1377

514.0

2237.0

Motif

Nuclear localization signal

Hgene

ARID1B

chr6:157100605

chr7:27809294

ENST00000350026

2036_2040

514.0

2237.0

Motif

Note=LXXLL

Hgene

ARID1B

chr6:157100605

chr7:27809294

ENST00000367148

1358_1377

514.0

2290.0

Motif

Nuclear localization signal

Hgene

ARID1B

chr6:157100605

chr7:27809294

ENST00000367148

2036_2040

514.0

2290.0

Motif

Note=LXXLL

Tgene

TAX1BP1

chr6:157100605

chr7:27809294

ENST00000265393

144_599

151.0

748.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

TAX1BP1

chr6:157100605

chr7:27809294

ENST00000396319

144_599

151.0

790.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

TAX1BP1

chr6:157100605

chr7:27809294

ENST00000543117

144_599

151.0

748.0

Coiled coil

Ontology_term=ECO:0000255

Top

Fusion Protein-Protein Interaction

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)

Gene

PPI interactors

Protein-protein interactors based on sequence similarity (STRING)

Gene	STRING network
ARID1B
TAX1BP1

- Retained interactions in fusion protein (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost interactions due to fusion (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs to ARID1B-TAX1BP1

Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Drug

Source

PMID

Top

Related Diseases to ARID1B-TAX1BP1

Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Disease

Source

PMID

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source