UTHEALTH HOME ABOUT SBMI A-Z WEBMAIL INSIDE THE UNIVERSITY

Home

Download

Statistics

Examples

Help

Contact

level1

	Fusion Gene Summary
	Fusion Gene Sample Information
	Fusion ORF Analysis
	Fusion Amino Acid Sequences
	Fusion Protein Functional Features
	Fusion Protein-Protein Interaction
	Related drugs with this fusion protein
	Related disease with this fusion protein

Fusion Protein:ARID2-SUPT20H

Fusion Protein Summary

Fusion gene summary

Fusion partner gene information	Fusion gene name: ARID2-SUPT20H
	FusionPDB ID: 6445
	FusionGDB2.0 ID: 6445
		Hgene	Tgene
	Gene symbol	ARID2	SUPT20H
	Gene ID	196528	55578
	Gene name	AT-rich interaction domain 2	SPT20 homolog, SAGA complex component
	Synonyms	BAF200\|CSS6\|p200	C13\|C13orf19\|FAM48A\|FP757\|P38IP\|SPT20
	Cytomap	12q12	13q13.3
	Type of gene	protein-coding	protein-coding
	Description	AT-rich interactive domain-containing protein 2ARID domain-containing protein 2AT rich interactive domain 2 (ARID, RFX-like)BRG1-associated factor 200zinc finger protein with activation potentialzipzap/p200	transcription factor SPT20 homologfamily with sequence similarity 48, member Aprotein FAM48Asuppressor of Ty 20 homologtranscription factor (p38 interacting protein)tumor rejection antigen
	Modification date	20200320	20200313
	UniProtAcc	Q68CP9	Q8NEM7
Ensembl transtripts involved in fusion gene	ENST ids	ENST00000479608, ENST00000334344, ENST00000422737, ENST00000444670, ENST00000457135,	ENST00000350612, ENST00000356185, ENST00000360252, ENST00000464744, ENST00000475892, ENST00000470359, ENST00000542180,
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)	* DoF score	17 X 9 X 12=1836	5 X 5 X 3=75
	# samples	17	5
	** MAII score	log2(17/1836*10)=-3.43295940727611 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(5/75*10)=-0.584962500721156 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)	PubMed: ARID2 [Title/Abstract] AND SUPT20H [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)	ARID2(46244956)-SUPT20H(37591465), # samples:1
Anticipated loss of major functional domain due to fusion event.	ARID2-SUPT20H seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. ARID2-SUPT20H seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. ARID2-SUPT20H seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. ARID2-SUPT20H seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	ARID2	GO:0006337	nucleosome disassembly	8895581
Hgene	ARID2	GO:0008285	negative regulation of cell proliferation	26169693
Hgene	ARID2	GO:0030336	negative regulation of cell migration	26169693

Fusion gene breakpoints across ARID2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across SUPT20H (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Top

Fusion Gene Sample Information

Fusion gene information from FusionGDB2.0.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChiTaRS5.0	N/A	AL691598	ARID2	chr12	46244956	+	SUPT20H	chr13	37591465	-

Top

Fusion ORF Analysis

Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000334344	ARID2	chr12	46244956	+	ENST00000360252	SUPT20H	chr13	37591465	-	4491	3807	139	2211	690
ENST00000334344	ARID2	chr12	46244956	+	ENST00000475892	SUPT20H	chr13	37591465	-	4314	3807	139	2211	690
ENST00000334344	ARID2	chr12	46244956	+	ENST00000356185	SUPT20H	chr13	37591465	-	4313	3807	139	2211	690
ENST00000334344	ARID2	chr12	46244956	+	ENST00000350612	SUPT20H	chr13	37591465	-	4417	3807	139	2211	690
ENST00000334344	ARID2	chr12	46244956	+	ENST00000464744	SUPT20H	chr13	37591465	-	4190	3807	139	2211	690
ENST00000422737	ARID2	chr12	46244956	+	ENST00000360252	SUPT20H	chr13	37591465	-	4240	3556	53	1960	635
ENST00000422737	ARID2	chr12	46244956	+	ENST00000475892	SUPT20H	chr13	37591465	-	4063	3556	53	1960	635
ENST00000422737	ARID2	chr12	46244956	+	ENST00000356185	SUPT20H	chr13	37591465	-	4062	3556	53	1960	635
ENST00000422737	ARID2	chr12	46244956	+	ENST00000350612	SUPT20H	chr13	37591465	-	4166	3556	53	1960	635
ENST00000422737	ARID2	chr12	46244956	+	ENST00000464744	SUPT20H	chr13	37591465	-	3939	3556	53	1960	635
ENST00000444670	ARID2	chr12	46244956	+	ENST00000360252	SUPT20H	chr13	37591465	-	3165	2481	819	2618	599
ENST00000444670	ARID2	chr12	46244956	+	ENST00000475892	SUPT20H	chr13	37591465	-	2988	2481	819	2618	599
ENST00000444670	ARID2	chr12	46244956	+	ENST00000356185	SUPT20H	chr13	37591465	-	2987	2481	819	2618	599
ENST00000444670	ARID2	chr12	46244956	+	ENST00000350612	SUPT20H	chr13	37591465	-	3091	2481	819	2618	599
ENST00000444670	ARID2	chr12	46244956	+	ENST00000464744	SUPT20H	chr13	37591465	-	2864	2481	819	2618	599

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000334344	ENST00000360252	ARID2	chr12	46244956	+	SUPT20H	chr13	37591465	-	0.002502314	0.9974976
ENST00000334344	ENST00000475892	ARID2	chr12	46244956	+	SUPT20H	chr13	37591465	-	0.003019507	0.9969805
ENST00000334344	ENST00000356185	ARID2	chr12	46244956	+	SUPT20H	chr13	37591465	-	0.003031494	0.99696857
ENST00000334344	ENST00000350612	ARID2	chr12	46244956	+	SUPT20H	chr13	37591465	-	0.003625514	0.9963744
ENST00000334344	ENST00000464744	ARID2	chr12	46244956	+	SUPT20H	chr13	37591465	-	0.003551189	0.99644876
ENST00000422737	ENST00000360252	ARID2	chr12	46244956	+	SUPT20H	chr13	37591465	-	0.002153247	0.9978467
ENST00000422737	ENST00000475892	ARID2	chr12	46244956	+	SUPT20H	chr13	37591465	-	0.002821778	0.9971782
ENST00000422737	ENST00000356185	ARID2	chr12	46244956	+	SUPT20H	chr13	37591465	-	0.002822436	0.9971776
ENST00000422737	ENST00000350612	ARID2	chr12	46244956	+	SUPT20H	chr13	37591465	-	0.003496097	0.99650395
ENST00000422737	ENST00000464744	ARID2	chr12	46244956	+	SUPT20H	chr13	37591465	-	0.003411659	0.99658835
ENST00000444670	ENST00000360252	ARID2	chr12	46244956	+	SUPT20H	chr13	37591465	-	0.004733419	0.99526656
ENST00000444670	ENST00000475892	ARID2	chr12	46244956	+	SUPT20H	chr13	37591465	-	0.006614089	0.993386
ENST00000444670	ENST00000356185	ARID2	chr12	46244956	+	SUPT20H	chr13	37591465	-	0.006626495	0.9933735
ENST00000444670	ENST00000350612	ARID2	chr12	46244956	+	SUPT20H	chr13	37591465	-	0.008070897	0.9919292
ENST00000444670	ENST00000464744	ARID2	chr12	46244956	+	SUPT20H	chr13	37591465	-	0.008002971	0.99199706

Top

Fusion Amino Acid Sequences

For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>6445_6445_1_ARID2-SUPT20H_ARID2_chr12_46244956_ENST00000334344_SUPT20H_chr13_37591465_ENST00000350612_length(amino acids)=690AA_BP=
MGFLKTSFEKIMANSTGKAPPDERRKGLAFLDELRQFHHSRGSPFKKIPAVGGKELDLHGLYTRVTTLGGFAKVSEKNQWGEIVEEFNFP
RSCSNAAFALKQYYLRYLEKYEKVHHFGEDDDEVPPGNPKPQLPIGAIPSSYNYQQHSVSDYLRQSYGLSMDFNSPNDYNKLVLSLLSGL
PNEVDFAINVCTLLSNESKHVMQLEKDPKIITLLLANAGVFDDTLGSFSTVFGEEWKEKTDRDFVKFWKDIVDDNEVRDLISDRNKSHEG
TSGEWIWESLFHPPRKLGINDIEGQRVLQIAVILRNLSFEEGNVKLLAANRTCLRFLLLSAHSHFISLRQLGLDTLGNIAAELLLDPVDF
KTTHLMFHTVTKCLMSRDRFLKMRGMEILGNLCKAEDNGVLICEYVDQDSYREIICHLTLPDVLLVISTLEVLYMLTEMGDVACTKIAKV
EKSIDMLVCLVSMDIQMFGPDALAAVKLIEHPSSSHQMLSEIRPQAIEQVQTQTHVASAPASRAVVAQHVAPPPGIVEIDSEKFACQWLN
AHFEVNPDCSVSRAEMYSEYLSTCSKLARGGILTSTGFYKCLRTVFPNHTVKRVEDSSSNGQAHIHVVGVKRRAIPLPIQMYYQQQPVST

--------------------------------------------------------------

>6445_6445_2_ARID2-SUPT20H_ARID2_chr12_46244956_ENST00000334344_SUPT20H_chr13_37591465_ENST00000356185_length(amino acids)=690AA_BP=
MGFLKTSFEKIMANSTGKAPPDERRKGLAFLDELRQFHHSRGSPFKKIPAVGGKELDLHGLYTRVTTLGGFAKVSEKNQWGEIVEEFNFP
RSCSNAAFALKQYYLRYLEKYEKVHHFGEDDDEVPPGNPKPQLPIGAIPSSYNYQQHSVSDYLRQSYGLSMDFNSPNDYNKLVLSLLSGL
PNEVDFAINVCTLLSNESKHVMQLEKDPKIITLLLANAGVFDDTLGSFSTVFGEEWKEKTDRDFVKFWKDIVDDNEVRDLISDRNKSHEG
TSGEWIWESLFHPPRKLGINDIEGQRVLQIAVILRNLSFEEGNVKLLAANRTCLRFLLLSAHSHFISLRQLGLDTLGNIAAELLLDPVDF
KTTHLMFHTVTKCLMSRDRFLKMRGMEILGNLCKAEDNGVLICEYVDQDSYREIICHLTLPDVLLVISTLEVLYMLTEMGDVACTKIAKV
EKSIDMLVCLVSMDIQMFGPDALAAVKLIEHPSSSHQMLSEIRPQAIEQVQTQTHVASAPASRAVVAQHVAPPPGIVEIDSEKFACQWLN
AHFEVNPDCSVSRAEMYSEYLSTCSKLARGGILTSTGFYKCLRTVFPNHTVKRVEDSSSNGQAHIHVVGVKRRAIPLPIQMYYQQQPVST

--------------------------------------------------------------

>6445_6445_3_ARID2-SUPT20H_ARID2_chr12_46244956_ENST00000334344_SUPT20H_chr13_37591465_ENST00000360252_length(amino acids)=690AA_BP=
MGFLKTSFEKIMANSTGKAPPDERRKGLAFLDELRQFHHSRGSPFKKIPAVGGKELDLHGLYTRVTTLGGFAKVSEKNQWGEIVEEFNFP
RSCSNAAFALKQYYLRYLEKYEKVHHFGEDDDEVPPGNPKPQLPIGAIPSSYNYQQHSVSDYLRQSYGLSMDFNSPNDYNKLVLSLLSGL
PNEVDFAINVCTLLSNESKHVMQLEKDPKIITLLLANAGVFDDTLGSFSTVFGEEWKEKTDRDFVKFWKDIVDDNEVRDLISDRNKSHEG
TSGEWIWESLFHPPRKLGINDIEGQRVLQIAVILRNLSFEEGNVKLLAANRTCLRFLLLSAHSHFISLRQLGLDTLGNIAAELLLDPVDF
KTTHLMFHTVTKCLMSRDRFLKMRGMEILGNLCKAEDNGVLICEYVDQDSYREIICHLTLPDVLLVISTLEVLYMLTEMGDVACTKIAKV
EKSIDMLVCLVSMDIQMFGPDALAAVKLIEHPSSSHQMLSEIRPQAIEQVQTQTHVASAPASRAVVAQHVAPPPGIVEIDSEKFACQWLN
AHFEVNPDCSVSRAEMYSEYLSTCSKLARGGILTSTGFYKCLRTVFPNHTVKRVEDSSSNGQAHIHVVGVKRRAIPLPIQMYYQQQPVST

--------------------------------------------------------------

>6445_6445_4_ARID2-SUPT20H_ARID2_chr12_46244956_ENST00000334344_SUPT20H_chr13_37591465_ENST00000464744_length(amino acids)=690AA_BP=
MGFLKTSFEKIMANSTGKAPPDERRKGLAFLDELRQFHHSRGSPFKKIPAVGGKELDLHGLYTRVTTLGGFAKVSEKNQWGEIVEEFNFP
RSCSNAAFALKQYYLRYLEKYEKVHHFGEDDDEVPPGNPKPQLPIGAIPSSYNYQQHSVSDYLRQSYGLSMDFNSPNDYNKLVLSLLSGL
PNEVDFAINVCTLLSNESKHVMQLEKDPKIITLLLANAGVFDDTLGSFSTVFGEEWKEKTDRDFVKFWKDIVDDNEVRDLISDRNKSHEG
TSGEWIWESLFHPPRKLGINDIEGQRVLQIAVILRNLSFEEGNVKLLAANRTCLRFLLLSAHSHFISLRQLGLDTLGNIAAELLLDPVDF
KTTHLMFHTVTKCLMSRDRFLKMRGMEILGNLCKAEDNGVLICEYVDQDSYREIICHLTLPDVLLVISTLEVLYMLTEMGDVACTKIAKV
EKSIDMLVCLVSMDIQMFGPDALAAVKLIEHPSSSHQMLSEIRPQAIEQVQTQTHVASAPASRAVVAQHVAPPPGIVEIDSEKFACQWLN
AHFEVNPDCSVSRAEMYSEYLSTCSKLARGGILTSTGFYKCLRTVFPNHTVKRVEDSSSNGQAHIHVVGVKRRAIPLPIQMYYQQQPVST

--------------------------------------------------------------

>6445_6445_5_ARID2-SUPT20H_ARID2_chr12_46244956_ENST00000334344_SUPT20H_chr13_37591465_ENST00000475892_length(amino acids)=690AA_BP=
MGFLKTSFEKIMANSTGKAPPDERRKGLAFLDELRQFHHSRGSPFKKIPAVGGKELDLHGLYTRVTTLGGFAKVSEKNQWGEIVEEFNFP
RSCSNAAFALKQYYLRYLEKYEKVHHFGEDDDEVPPGNPKPQLPIGAIPSSYNYQQHSVSDYLRQSYGLSMDFNSPNDYNKLVLSLLSGL
PNEVDFAINVCTLLSNESKHVMQLEKDPKIITLLLANAGVFDDTLGSFSTVFGEEWKEKTDRDFVKFWKDIVDDNEVRDLISDRNKSHEG
TSGEWIWESLFHPPRKLGINDIEGQRVLQIAVILRNLSFEEGNVKLLAANRTCLRFLLLSAHSHFISLRQLGLDTLGNIAAELLLDPVDF
KTTHLMFHTVTKCLMSRDRFLKMRGMEILGNLCKAEDNGVLICEYVDQDSYREIICHLTLPDVLLVISTLEVLYMLTEMGDVACTKIAKV
EKSIDMLVCLVSMDIQMFGPDALAAVKLIEHPSSSHQMLSEIRPQAIEQVQTQTHVASAPASRAVVAQHVAPPPGIVEIDSEKFACQWLN
AHFEVNPDCSVSRAEMYSEYLSTCSKLARGGILTSTGFYKCLRTVFPNHTVKRVEDSSSNGQAHIHVVGVKRRAIPLPIQMYYQQQPVST

--------------------------------------------------------------

>6445_6445_6_ARID2-SUPT20H_ARID2_chr12_46244956_ENST00000422737_SUPT20H_chr13_37591465_ENST00000350612_length(amino acids)=635AA_BP=
MDLHGLYTRVTTLGGFAKVSEKNQWGEIVEEFNFPRSCSNAAFALKQYYLRYLEKYEKVHHFGEDDDEVPPGNPKPQLPIGAIPSSYNYQ
QHSVSDYLRQSYGLSMDFNSPNDYNKLVLSLLSGLPNEVDFAINVCTLLSNESKHVMQLEKDPKIITLLLANAGVFDDTLGSFSTVFGEE
WKEKTDRDFVKFWKDIVDDNEVRDLISDRNKSHEGTSGEWIWESLFHPPRKLGINDIEGQRVLQIAVILRNLSFEEGNVKLLAANRTCLR
FLLLSAHSHFISLRQLGLDTLGNIAAELLLDPVDFKTTHLMFHTVTKCLMSRDRFLKMRGMEILGNLCKAEDNGVLICEYVDQDSYREII
CHLTLPDVLLVISTLEVLYMLTEMGDVACTKIAKVEKSIDMLVCLVSMDIQMFGPDALAAVKLIEHPSSSHQMLSEIRPQAIEQVQTQTH
VASAPASRAVVAQHVAPPPGIVEIDSEKFACQWLNAHFEVNPDCSVSRAEMYSEYLSTCSKLARGGILTSTGFYKCLRTVFPNHTVKRVE
DSSSNGQAHIHVVGVKRRAIPLPIQMYYQQQPVSTSVVRVDSVPDVSPAPSPAVHQHPHHSRYKYKFSSPNKYRCKFNLNSRMQELVSLP

--------------------------------------------------------------

>6445_6445_7_ARID2-SUPT20H_ARID2_chr12_46244956_ENST00000422737_SUPT20H_chr13_37591465_ENST00000356185_length(amino acids)=635AA_BP=
MDLHGLYTRVTTLGGFAKVSEKNQWGEIVEEFNFPRSCSNAAFALKQYYLRYLEKYEKVHHFGEDDDEVPPGNPKPQLPIGAIPSSYNYQ
QHSVSDYLRQSYGLSMDFNSPNDYNKLVLSLLSGLPNEVDFAINVCTLLSNESKHVMQLEKDPKIITLLLANAGVFDDTLGSFSTVFGEE
WKEKTDRDFVKFWKDIVDDNEVRDLISDRNKSHEGTSGEWIWESLFHPPRKLGINDIEGQRVLQIAVILRNLSFEEGNVKLLAANRTCLR
FLLLSAHSHFISLRQLGLDTLGNIAAELLLDPVDFKTTHLMFHTVTKCLMSRDRFLKMRGMEILGNLCKAEDNGVLICEYVDQDSYREII
CHLTLPDVLLVISTLEVLYMLTEMGDVACTKIAKVEKSIDMLVCLVSMDIQMFGPDALAAVKLIEHPSSSHQMLSEIRPQAIEQVQTQTH
VASAPASRAVVAQHVAPPPGIVEIDSEKFACQWLNAHFEVNPDCSVSRAEMYSEYLSTCSKLARGGILTSTGFYKCLRTVFPNHTVKRVE
DSSSNGQAHIHVVGVKRRAIPLPIQMYYQQQPVSTSVVRVDSVPDVSPAPSPAVHQHPHHSRYKYKFSSPNKYRCKFNLNSRMQELVSLP

--------------------------------------------------------------

>6445_6445_8_ARID2-SUPT20H_ARID2_chr12_46244956_ENST00000422737_SUPT20H_chr13_37591465_ENST00000360252_length(amino acids)=635AA_BP=
MDLHGLYTRVTTLGGFAKVSEKNQWGEIVEEFNFPRSCSNAAFALKQYYLRYLEKYEKVHHFGEDDDEVPPGNPKPQLPIGAIPSSYNYQ
QHSVSDYLRQSYGLSMDFNSPNDYNKLVLSLLSGLPNEVDFAINVCTLLSNESKHVMQLEKDPKIITLLLANAGVFDDTLGSFSTVFGEE
WKEKTDRDFVKFWKDIVDDNEVRDLISDRNKSHEGTSGEWIWESLFHPPRKLGINDIEGQRVLQIAVILRNLSFEEGNVKLLAANRTCLR
FLLLSAHSHFISLRQLGLDTLGNIAAELLLDPVDFKTTHLMFHTVTKCLMSRDRFLKMRGMEILGNLCKAEDNGVLICEYVDQDSYREII
CHLTLPDVLLVISTLEVLYMLTEMGDVACTKIAKVEKSIDMLVCLVSMDIQMFGPDALAAVKLIEHPSSSHQMLSEIRPQAIEQVQTQTH
VASAPASRAVVAQHVAPPPGIVEIDSEKFACQWLNAHFEVNPDCSVSRAEMYSEYLSTCSKLARGGILTSTGFYKCLRTVFPNHTVKRVE
DSSSNGQAHIHVVGVKRRAIPLPIQMYYQQQPVSTSVVRVDSVPDVSPAPSPAVHQHPHHSRYKYKFSSPNKYRCKFNLNSRMQELVSLP

--------------------------------------------------------------

>6445_6445_9_ARID2-SUPT20H_ARID2_chr12_46244956_ENST00000422737_SUPT20H_chr13_37591465_ENST00000464744_length(amino acids)=635AA_BP=
MDLHGLYTRVTTLGGFAKVSEKNQWGEIVEEFNFPRSCSNAAFALKQYYLRYLEKYEKVHHFGEDDDEVPPGNPKPQLPIGAIPSSYNYQ
QHSVSDYLRQSYGLSMDFNSPNDYNKLVLSLLSGLPNEVDFAINVCTLLSNESKHVMQLEKDPKIITLLLANAGVFDDTLGSFSTVFGEE
WKEKTDRDFVKFWKDIVDDNEVRDLISDRNKSHEGTSGEWIWESLFHPPRKLGINDIEGQRVLQIAVILRNLSFEEGNVKLLAANRTCLR
FLLLSAHSHFISLRQLGLDTLGNIAAELLLDPVDFKTTHLMFHTVTKCLMSRDRFLKMRGMEILGNLCKAEDNGVLICEYVDQDSYREII
CHLTLPDVLLVISTLEVLYMLTEMGDVACTKIAKVEKSIDMLVCLVSMDIQMFGPDALAAVKLIEHPSSSHQMLSEIRPQAIEQVQTQTH
VASAPASRAVVAQHVAPPPGIVEIDSEKFACQWLNAHFEVNPDCSVSRAEMYSEYLSTCSKLARGGILTSTGFYKCLRTVFPNHTVKRVE
DSSSNGQAHIHVVGVKRRAIPLPIQMYYQQQPVSTSVVRVDSVPDVSPAPSPAVHQHPHHSRYKYKFSSPNKYRCKFNLNSRMQELVSLP

--------------------------------------------------------------

>6445_6445_10_ARID2-SUPT20H_ARID2_chr12_46244956_ENST00000422737_SUPT20H_chr13_37591465_ENST00000475892_length(amino acids)=635AA_BP=
MDLHGLYTRVTTLGGFAKVSEKNQWGEIVEEFNFPRSCSNAAFALKQYYLRYLEKYEKVHHFGEDDDEVPPGNPKPQLPIGAIPSSYNYQ
QHSVSDYLRQSYGLSMDFNSPNDYNKLVLSLLSGLPNEVDFAINVCTLLSNESKHVMQLEKDPKIITLLLANAGVFDDTLGSFSTVFGEE
WKEKTDRDFVKFWKDIVDDNEVRDLISDRNKSHEGTSGEWIWESLFHPPRKLGINDIEGQRVLQIAVILRNLSFEEGNVKLLAANRTCLR
FLLLSAHSHFISLRQLGLDTLGNIAAELLLDPVDFKTTHLMFHTVTKCLMSRDRFLKMRGMEILGNLCKAEDNGVLICEYVDQDSYREII
CHLTLPDVLLVISTLEVLYMLTEMGDVACTKIAKVEKSIDMLVCLVSMDIQMFGPDALAAVKLIEHPSSSHQMLSEIRPQAIEQVQTQTH
VASAPASRAVVAQHVAPPPGIVEIDSEKFACQWLNAHFEVNPDCSVSRAEMYSEYLSTCSKLARGGILTSTGFYKCLRTVFPNHTVKRVE
DSSSNGQAHIHVVGVKRRAIPLPIQMYYQQQPVSTSVVRVDSVPDVSPAPSPAVHQHPHHSRYKYKFSSPNKYRCKFNLNSRMQELVSLP

--------------------------------------------------------------

>6445_6445_11_ARID2-SUPT20H_ARID2_chr12_46244956_ENST00000444670_SUPT20H_chr13_37591465_ENST00000350612_length(amino acids)=599AA_BP=
MQVQPQQSNAGVGQPASGESSLIKQLLLPKRGPSTPGGKLILPAPQIPPPNNARAPSPQVVYQVASNQAAGFGVQGQTPAQQLLVGQQNV
QLVPSAMPPSGGVQTVPISNLQILPGPLISNSPATIFQGTSGNQVTITVVPNTSFAPATVSQGNATQLIAPAGITMSGTQTGVGLPVQTL
PATQASPAGQSSCTTATPPFKGDKIICQKEEEAKEATGLHVHERKIEVMENPSCRRGATNTSNGDTKENEMHVGSLLNGRKYSDSSLPPS
NSGKIQSETNQCSLISNGPSLELGENGASGKQNSEQIDMQDIKSDLRKPLVNGICDFDKGDGSHLSKNIPNHKTSNHVGNGEISPMEPQG
TLDITQQDTAKGDQLERISNGPVLTLGGSSVSSIQEASNAATQQFSGTDLLNGPLASSLNSDVPQQRPSVVVSPHSTTSVIQGHQIIAVP
DSGSKVSHSPALSSDVRSTNGTAECKTVKRPAEDTDRETVAGIPNKVGVRIVTISDPNNAGCSATMVAVPAGADPSTVAKVAIESAVQQK

--------------------------------------------------------------

>6445_6445_12_ARID2-SUPT20H_ARID2_chr12_46244956_ENST00000444670_SUPT20H_chr13_37591465_ENST00000356185_length(amino acids)=599AA_BP=
MQVQPQQSNAGVGQPASGESSLIKQLLLPKRGPSTPGGKLILPAPQIPPPNNARAPSPQVVYQVASNQAAGFGVQGQTPAQQLLVGQQNV
QLVPSAMPPSGGVQTVPISNLQILPGPLISNSPATIFQGTSGNQVTITVVPNTSFAPATVSQGNATQLIAPAGITMSGTQTGVGLPVQTL
PATQASPAGQSSCTTATPPFKGDKIICQKEEEAKEATGLHVHERKIEVMENPSCRRGATNTSNGDTKENEMHVGSLLNGRKYSDSSLPPS
NSGKIQSETNQCSLISNGPSLELGENGASGKQNSEQIDMQDIKSDLRKPLVNGICDFDKGDGSHLSKNIPNHKTSNHVGNGEISPMEPQG
TLDITQQDTAKGDQLERISNGPVLTLGGSSVSSIQEASNAATQQFSGTDLLNGPLASSLNSDVPQQRPSVVVSPHSTTSVIQGHQIIAVP
DSGSKVSHSPALSSDVRSTNGTAECKTVKRPAEDTDRETVAGIPNKVGVRIVTISDPNNAGCSATMVAVPAGADPSTVAKVAIESAVQQK

--------------------------------------------------------------

>6445_6445_13_ARID2-SUPT20H_ARID2_chr12_46244956_ENST00000444670_SUPT20H_chr13_37591465_ENST00000360252_length(amino acids)=599AA_BP=
MQVQPQQSNAGVGQPASGESSLIKQLLLPKRGPSTPGGKLILPAPQIPPPNNARAPSPQVVYQVASNQAAGFGVQGQTPAQQLLVGQQNV
QLVPSAMPPSGGVQTVPISNLQILPGPLISNSPATIFQGTSGNQVTITVVPNTSFAPATVSQGNATQLIAPAGITMSGTQTGVGLPVQTL
PATQASPAGQSSCTTATPPFKGDKIICQKEEEAKEATGLHVHERKIEVMENPSCRRGATNTSNGDTKENEMHVGSLLNGRKYSDSSLPPS
NSGKIQSETNQCSLISNGPSLELGENGASGKQNSEQIDMQDIKSDLRKPLVNGICDFDKGDGSHLSKNIPNHKTSNHVGNGEISPMEPQG
TLDITQQDTAKGDQLERISNGPVLTLGGSSVSSIQEASNAATQQFSGTDLLNGPLASSLNSDVPQQRPSVVVSPHSTTSVIQGHQIIAVP
DSGSKVSHSPALSSDVRSTNGTAECKTVKRPAEDTDRETVAGIPNKVGVRIVTISDPNNAGCSATMVAVPAGADPSTVAKVAIESAVQQK

--------------------------------------------------------------

>6445_6445_14_ARID2-SUPT20H_ARID2_chr12_46244956_ENST00000444670_SUPT20H_chr13_37591465_ENST00000464744_length(amino acids)=599AA_BP=
MQVQPQQSNAGVGQPASGESSLIKQLLLPKRGPSTPGGKLILPAPQIPPPNNARAPSPQVVYQVASNQAAGFGVQGQTPAQQLLVGQQNV
QLVPSAMPPSGGVQTVPISNLQILPGPLISNSPATIFQGTSGNQVTITVVPNTSFAPATVSQGNATQLIAPAGITMSGTQTGVGLPVQTL
PATQASPAGQSSCTTATPPFKGDKIICQKEEEAKEATGLHVHERKIEVMENPSCRRGATNTSNGDTKENEMHVGSLLNGRKYSDSSLPPS
NSGKIQSETNQCSLISNGPSLELGENGASGKQNSEQIDMQDIKSDLRKPLVNGICDFDKGDGSHLSKNIPNHKTSNHVGNGEISPMEPQG
TLDITQQDTAKGDQLERISNGPVLTLGGSSVSSIQEASNAATQQFSGTDLLNGPLASSLNSDVPQQRPSVVVSPHSTTSVIQGHQIIAVP
DSGSKVSHSPALSSDVRSTNGTAECKTVKRPAEDTDRETVAGIPNKVGVRIVTISDPNNAGCSATMVAVPAGADPSTVAKVAIESAVQQK

--------------------------------------------------------------

>6445_6445_15_ARID2-SUPT20H_ARID2_chr12_46244956_ENST00000444670_SUPT20H_chr13_37591465_ENST00000475892_length(amino acids)=599AA_BP=
MQVQPQQSNAGVGQPASGESSLIKQLLLPKRGPSTPGGKLILPAPQIPPPNNARAPSPQVVYQVASNQAAGFGVQGQTPAQQLLVGQQNV
QLVPSAMPPSGGVQTVPISNLQILPGPLISNSPATIFQGTSGNQVTITVVPNTSFAPATVSQGNATQLIAPAGITMSGTQTGVGLPVQTL
PATQASPAGQSSCTTATPPFKGDKIICQKEEEAKEATGLHVHERKIEVMENPSCRRGATNTSNGDTKENEMHVGSLLNGRKYSDSSLPPS
NSGKIQSETNQCSLISNGPSLELGENGASGKQNSEQIDMQDIKSDLRKPLVNGICDFDKGDGSHLSKNIPNHKTSNHVGNGEISPMEPQG
TLDITQQDTAKGDQLERISNGPVLTLGGSSVSSIQEASNAATQQFSGTDLLNGPLASSLNSDVPQQRPSVVVSPHSTTSVIQGHQIIAVP
DSGSKVSHSPALSSDVRSTNGTAECKTVKRPAEDTDRETVAGIPNKVGVRIVTISDPNNAGCSATMVAVPAGADPSTVAKVAIESAVQQK

--------------------------------------------------------------

Top

Fusion Protein Functional Features

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr12:46244956/chr13:37591465)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
ARID2 Q68CP9	SUPT20H Q8NEM7
FUNCTION: Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Required for the stability of the SWI/SNF chromatin remodeling complex SWI/SNF-B (PBAF). May be involved in targeting the complex to different genes. May be involved in regulating transcriptional activation of cardiac genes. {ECO:0000269\|PubMed:16782067, ECO:0000303\|PubMed:22952240, ECO:0000303\|PubMed:26601204}.	FUNCTION: Required for MAP kinase p38 (MAPK11, MAPK12, MAPK13 and/or MAPK14) activation during gastrulation. Required for down-regulation of E-cadherin during gastrulation by regulating E-cadherin protein level downstream from NCK-interacting kinase (NIK) and independently of the regulation of transcription by FGF signaling and Snail (By similarity). Required for starvation-induced ATG9A trafficking during autophagy. {ECO:0000250, ECO:0000269\|PubMed:19893488}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
* Minus value of BPloci means that the break pointn is located before the CDS.

- Retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

SUPT20H

chr12:46244956

chr13:37591465

ENST00000350612

636_754

780.0

Compositional bias

Note=Gln-rich

Tgene

SUPT20H

chr12:46244956

chr13:37591465

ENST00000356185

636_754

734.0

Compositional bias

Note=Gln-rich

Tgene

SUPT20H

chr12:46244956

chr13:37591465

ENST00000360252

636_754

734.0

Compositional bias

Note=Gln-rich

Tgene

SUPT20H

chr12:46244956

chr13:37591465

ENST00000464744

636_754

734.0

Compositional bias

Note=Gln-rich

- Not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

ARID2

chr12:46244956

chr13:37591465

ENST00000334344

793_1128

1836.0

Compositional bias

Note=Gln-rich

Hgene

ARID2

chr12:46244956

chr13:37591465

ENST00000334344

524_603

1836.0

DNA binding

RFX-type winged-helix

Hgene

ARID2

chr12:46244956

chr13:37591465

ENST00000334344

13_105

1836.0

Domain

ARID

Hgene

ARID2

chr12:46244956

chr13:37591465

ENST00000334344

313_317

1836.0

Motif

Note=LXXLL

Hgene

ARID2

chr12:46244956

chr13:37591465

ENST00000334344

1632_1657

1836.0

Zinc finger

Note=C2H2-type

Top

Fusion Protein-Protein Interaction

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)

Gene

PPI interactors

Protein-protein interactors based on sequence similarity (STRING)

Gene	STRING network
ARID2
SUPT20H

- Retained interactions in fusion protein (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost interactions due to fusion (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs to ARID2-SUPT20H

Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Drug

Source

PMID

Top

Related Diseases to ARID2-SUPT20H

Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Disease

Source

PMID

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source