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Center for Computational Systems Medicine level2
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein Structure

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pLDDT scores

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Ramachandran Plot of Fusion Protein Structure

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:PHC3-FNDC3B

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: PHC3-FNDC3B
FusionPDB ID: 64741
FusionGDB2.0 ID: 64741
HgeneTgene
Gene symbol

PHC3

FNDC3B

Gene ID

80012

64778

Gene namepolyhomeotic homolog 3fibronectin type III domain containing 3B
SynonymsEDR3|HPH3FAD104|PRO4979|YVTM2421
Cytomap

3q26.2

3q26.31

Type of geneprotein-codingprotein-coding
Descriptionpolyhomeotic-like protein 3early development regulator 3early development regulatory protein 3homolog of polyhomeotic 3polyhomeotic like 3fibronectin type III domain-containing protein 3BHCV NS5A-binding protein 37factor for adipocyte differentiation 104
Modification date2020031320200313
UniProtAcc.

Q53EP0

Ensembl transtripts involved in fusion geneENST idsENST00000467570, ENST00000494943, 
ENST00000495893, ENST00000474275, 
ENST00000481639, ENST00000497658, 
ENST00000392699, ENST00000421757, 
ENST00000423424, ENST00000476794, 
ENST00000336824, ENST00000415807, 
ENST00000416957, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score15 X 15 X 11=247521 X 23 X 11=5313
# samples 2028
** MAII scorelog2(20/2475*10)=-3.62935662007961
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(28/5313*10)=-4.2460279805281
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: PHC3 [Title/Abstract] AND FNDC3B [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)PHC3(169831148)-FNDC3B(172114954), # samples:3
PHC3(169863211)-FNDC3B(172114954), # samples:3
Anticipated loss of major functional domain due to fusion event.PHC3-FNDC3B seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
PHC3-FNDC3B seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
PHC3-FNDC3B seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
PHC3-FNDC3B seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
PHC3-FNDC3B seems lost the major protein functional domain in Hgene partner, which is a epigenetic factor due to the frame-shifted ORF.
PHC3-FNDC3B seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
PHC3-FNDC3B seems lost the major protein functional domain in Hgene partner, which is a tumor suppressor due to the frame-shifted ORF.
PHC3-FNDC3B seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across PHC3 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across FNDC3B (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4ESCATCGA-L5-A88S-01APHC3chr3

169831148

-FNDC3Bchr3

172114954

+
ChimerDB4ESCATCGA-L5-A88SPHC3chr3

169824619

-FNDC3Bchr3

172114953

+
ChimerDB4ESCATCGA-L5-A88SPHC3chr3

169824620

-FNDC3Bchr3

172114954

+
ChimerDB4ESCATCGA-L5-A88SPHC3chr3

169831148

-FNDC3Bchr3

172114954

+
ChimerDB4LUSCTCGA-56-1622-01APHC3chr3

169863211

-FNDC3Bchr3

172114954

+
ChimerDB4LUSCTCGA-56-1622PHC3chr3

169863210

-FNDC3Bchr3

172114953

+
ChimerDB4LUSCTCGA-56-1622PHC3chr3

169863211

-FNDC3Bchr3

172114954

+


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000495893PHC3chr3169831148-ENST00000336824FNDC3Bchr3172114954+68872385322542836
ENST00000494943PHC3chr3169831148-ENST00000336824FNDC3Bchr3172114954+68882386692543824
ENST00000467570PHC3chr3169831148-ENST00000336824FNDC3Bchr3172114954+67302228342385783
ENST00000495893PHC3chr3169863211-ENST00000415807FNDC3Bchr3172114954+2312704321015327
ENST00000495893PHC3chr3169863211-ENST00000416957FNDC3Bchr3172114954+1022704321015327
ENST00000494943PHC3chr3169863211-ENST00000415807FNDC3Bchr3172114954+2313705691016315
ENST00000494943PHC3chr3169863211-ENST00000416957FNDC3Bchr3172114954+1023705691016315
ENST00000467570PHC3chr3169863211-ENST00000415807FNDC3Bchr3172114954+215554734858274
ENST00000467570PHC3chr3169863211-ENST00000416957FNDC3Bchr3172114954+86554734858274
ENST00000495893PHC3chr3169863210-ENST00000415807FNDC3Bchr3172114953+2312704321015327
ENST00000495893PHC3chr3169863210-ENST00000416957FNDC3Bchr3172114953+1022704321015327
ENST00000494943PHC3chr3169863210-ENST00000415807FNDC3Bchr3172114953+2313705691016315
ENST00000494943PHC3chr3169863210-ENST00000416957FNDC3Bchr3172114953+1023705691016315
ENST00000467570PHC3chr3169863210-ENST00000415807FNDC3Bchr3172114953+215554734858274
ENST00000467570PHC3chr3169863210-ENST00000416957FNDC3Bchr3172114953+86554734858274

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000495893ENST00000336824PHC3chr3169831148-FNDC3Bchr3172114954+0.0011823860.9988176
ENST00000494943ENST00000336824PHC3chr3169831148-FNDC3Bchr3172114954+0.0006891180.99931085
ENST00000467570ENST00000336824PHC3chr3169831148-FNDC3Bchr3172114954+0.0008376610.9991623
ENST00000495893ENST00000415807PHC3chr3169863211-FNDC3Bchr3172114954+0.0011276530.99887234
ENST00000495893ENST00000416957PHC3chr3169863211-FNDC3Bchr3172114954+0.0150142830.9849857
ENST00000494943ENST00000415807PHC3chr3169863211-FNDC3Bchr3172114954+0.0036724430.9963276
ENST00000494943ENST00000416957PHC3chr3169863211-FNDC3Bchr3172114954+0.0368763170.9631237
ENST00000467570ENST00000415807PHC3chr3169863211-FNDC3Bchr3172114954+0.0019201110.9980799
ENST00000467570ENST00000416957PHC3chr3169863211-FNDC3Bchr3172114954+0.0105149320.9894851
ENST00000495893ENST00000415807PHC3chr3169863210-FNDC3Bchr3172114953+0.0011276530.99887234
ENST00000495893ENST00000416957PHC3chr3169863210-FNDC3Bchr3172114953+0.0150142830.9849857
ENST00000494943ENST00000415807PHC3chr3169863210-FNDC3Bchr3172114953+0.0036724430.9963276
ENST00000494943ENST00000416957PHC3chr3169863210-FNDC3Bchr3172114953+0.0368763170.9631237
ENST00000467570ENST00000415807PHC3chr3169863210-FNDC3Bchr3172114953+0.0019201110.9980799
ENST00000467570ENST00000416957PHC3chr3169863210-FNDC3Bchr3172114953+0.0105149320.9894851

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>64741_64741_1_PHC3-FNDC3B_PHC3_chr3_169831148_ENST00000467570_FNDC3B_chr3_172114954_ENST00000336824_length(amino acids)=783AA_BP=730
MAEAEFKDHSTAMDTEPNPGTSSVSTTTSSTTTTTITTSSSRMQQPQISVYSGSDRHAVQVIQQALHRPPSSAAQYLQQMYAAQQQHLML
HTAALQQQHLSSSQLQSLAAVQASLSSGRPSTSPTGSVTQQSSMSQTSLIFTPATTVAAVQSDIPVVSSSSSSSCQSAATQVQNLTLRSQ
KLGVLSSSQNGPPKSTSQTQSLTICHNKTTVTSSKISQRDPSPESNKKGESPSLESRSTAVTRTSSIHQLIAPASYSPIQPHSLIKHQQI
PLHSPPSKVSHHQLILQQQQQQIQPITLQNSTQDPPPSQHCIPLQNHGLPPAPSNAQSQHCSPIQSHPSPLTVSPNQSQSAQQSVVVSPP
PPHSPSQSPTIIIHPQALIQPHPLVSSALQPGPNLQQSTANQVQATAQLNLPSHLPLPASPVVHIGPVQQSALVSPGQQIVSPSHQQYSS
LQSSPIPIASPPQMSTSPPAQIPPLPLQSMQSLQVQPEILSQGQVLVQNALVSEEELPAAEALVQLPFQTLPPPQTVAVNLQVQPPAPVD
PPVVYQVEDVCEEEMPEESDECVRMDRTPPPPTLSPAAITVGRGEDLTSEHPLLEQVELPAVASVSASVIKSPSDPSHVSVPPPPLLLPA
ATTRSNSTSMHSSIPSIENKPPQAIVKPQILTHVIEGFVIQEGLEPFPVSRSSLLIEQPVKKRPLLDNQVINSVCVQPELQNNTKHADNS

--------------------------------------------------------------

>64741_64741_2_PHC3-FNDC3B_PHC3_chr3_169831148_ENST00000494943_FNDC3B_chr3_172114954_ENST00000336824_length(amino acids)=824AA_BP=771
MDTEPNPGTSSVSTTTSSTTTTTITTSSSRMQQPQISVYSGSDRHAVQVIQQALHRPPSSAAQYLQQMYAAQQQHLMLHTAALQQQHLSS
SQLQSLAAVQASLSSGRPSTSPTGSVTQQSSMSQTSINLSTSPTPAQLISRSQASSSTSGSITQQTMLLGSTSPTLTASQAQMYLRAQML
IFTPATTVAAVQSDIPVVSSSSSSSCQSAATQVQNLTLRSQKLGVLSSSQNGPPKSTSQTQSLTICHNKTTVTSSKISQRDPSPESNKKG
ESPSLESRSTAVTRTSSIHQLIAPASYSPIQPHSLIKHQQIPLHSPPSKVSHHQLILQQQQQQIQPITLQNSTQDPPPSQHCIPLQNHGL
PPAPSNAQSQHCSPIQSHPSPLTVSPNQSQSAQQSVVVSPPPPHSPSQSPTIIIHPQALIQPHPLVSSALQPGPNLQQSTANQVQATAQL
NLPSHLPLPASPVVHIGPVQQSALVSPGQQIVSPSHQQYSSLQSSPIPIASPPQMSTSPPAQIPPLPLQSMQSLQVQPEILSQGQVLVQN
ALVSEEELPAAEALVQLPFQTLPPPQTVAVNLQVQPPAPVDPPVVYQVEDVCEEEMPEESDECVRMDRTPPPPTLSPAAITVGRGEDLTS
EHPLLEQVELPAVASVSASVIKSPSDPSHVSVPPPPLLLPAATTRSNSTSMHSSIPSIENKPPQAIVKPQILTHVIEGFVIQEGLEPFPV
SRSSLLIEQPVKKRPLLDNQVINSVCVQPELQNNTKHADNSSDTEMEDMIAEGVQGRRSHIPNLRPPDQHRLQVPRMCVSSLFRHLSGAK

--------------------------------------------------------------

>64741_64741_3_PHC3-FNDC3B_PHC3_chr3_169831148_ENST00000495893_FNDC3B_chr3_172114954_ENST00000336824_length(amino acids)=836AA_BP=783
MAEAEFKDHSTAMDTEPNPGTSSVSTTTSSTTTTTITTSSSRMQQPQISVYSGSDRHAVQVIQQALHRPPSSAAQYLQQMYAAQQQHLML
HTAALQQQHLSSSQLQSLAAVQASLSSGRPSTSPTGSVTQQSSMSQTSINLSTSPTPAQLISRSQASSSTSGSITQQTMLLGSTSPTLTA
SQAQMYLRAQMLIFTPATTVAAVQSDIPVVSSSSSSSCQSAATQVQNLTLRSQKLGVLSSSQNGPPKSTSQTQSLTICHNKTTVTSSKIS
QRDPSPESNKKGESPSLESRSTAVTRTSSIHQLIAPASYSPIQPHSLIKHQQIPLHSPPSKVSHHQLILQQQQQQIQPITLQNSTQDPPP
SQHCIPLQNHGLPPAPSNAQSQHCSPIQSHPSPLTVSPNQSQSAQQSVVVSPPPPHSPSQSPTIIIHPQALIQPHPLVSSALQPGPNLQQ
STANQVQATAQLNLPSHLPLPASPVVHIGPVQQSALVSPGQQIVSPSHQQYSSLQSSPIPIASPPQMSTSPPAQIPPLPLQSMQSLQVQP
EILSQGQVLVQNALVSEEELPAAEALVQLPFQTLPPPQTVAVNLQVQPPAPVDPPVVYQVEDVCEEEMPEESDECVRMDRTPPPPTLSPA
AITVGRGEDLTSEHPLLEQVELPAVASVSASVIKSPSDPSHVSVPPPPLLLPAATTRSNSTSMHSSIPSIENKPPQAIVKPQILTHVIEG
FVIQEGLEPFPVSRSSLLIEQPVKKRPLLDNQVINSVCVQPELQNNTKHADNSSDTEMEDMIAEGVQGRRSHIPNLRPPDQHRLQVPRMC

--------------------------------------------------------------

>64741_64741_4_PHC3-FNDC3B_PHC3_chr3_169863210_ENST00000467570_FNDC3B_chr3_172114953_ENST00000415807_length(amino acids)=274AA_BP=171
MAEAEFKDHSTAMDTEPNPGTSSVSTTTSSTTTTTITTSSSRMQQPQISVYSGSDRHAVQVIQQALHRPPSSAAQYLQQMYAAQQQHLML
HTAALQQQHLSSSQLQSLAAVQASLSSGRPSTSPTGSVTQQSSMSQTSLIFTPATTVAAVQSDIPVVSSSSSSSCQSAATQVYKGEEATF
QISGLQTNTDYRFRVCACRRCLDTSQELSGAFSPSAAFVLQRSEVMLTGDMGSLDDPKMKSMMPTDEQFAAIIVLGFATLSILFAFILQY

--------------------------------------------------------------

>64741_64741_5_PHC3-FNDC3B_PHC3_chr3_169863210_ENST00000467570_FNDC3B_chr3_172114953_ENST00000416957_length(amino acids)=274AA_BP=171
MAEAEFKDHSTAMDTEPNPGTSSVSTTTSSTTTTTITTSSSRMQQPQISVYSGSDRHAVQVIQQALHRPPSSAAQYLQQMYAAQQQHLML
HTAALQQQHLSSSQLQSLAAVQASLSSGRPSTSPTGSVTQQSSMSQTSLIFTPATTVAAVQSDIPVVSSSSSSSCQSAATQVYKGEEATF
QISGLQTNTDYRFRVCACRRCLDTSQELSGAFSPSAAFVLQRSEVMLTGDMGSLDDPKMKSMMPTDEQFAAIIVLGFATLSILFAFILQY

--------------------------------------------------------------

>64741_64741_6_PHC3-FNDC3B_PHC3_chr3_169863210_ENST00000494943_FNDC3B_chr3_172114953_ENST00000415807_length(amino acids)=315AA_BP=212
MDTEPNPGTSSVSTTTSSTTTTTITTSSSRMQQPQISVYSGSDRHAVQVIQQALHRPPSSAAQYLQQMYAAQQQHLMLHTAALQQQHLSS
SQLQSLAAVQASLSSGRPSTSPTGSVTQQSSMSQTSINLSTSPTPAQLISRSQASSSTSGSITQQTMLLGSTSPTLTASQAQMYLRAQML
IFTPATTVAAVQSDIPVVSSSSSSSCQSAATQVYKGEEATFQISGLQTNTDYRFRVCACRRCLDTSQELSGAFSPSAAFVLQRSEVMLTG

--------------------------------------------------------------

>64741_64741_7_PHC3-FNDC3B_PHC3_chr3_169863210_ENST00000494943_FNDC3B_chr3_172114953_ENST00000416957_length(amino acids)=315AA_BP=212
MDTEPNPGTSSVSTTTSSTTTTTITTSSSRMQQPQISVYSGSDRHAVQVIQQALHRPPSSAAQYLQQMYAAQQQHLMLHTAALQQQHLSS
SQLQSLAAVQASLSSGRPSTSPTGSVTQQSSMSQTSINLSTSPTPAQLISRSQASSSTSGSITQQTMLLGSTSPTLTASQAQMYLRAQML
IFTPATTVAAVQSDIPVVSSSSSSSCQSAATQVYKGEEATFQISGLQTNTDYRFRVCACRRCLDTSQELSGAFSPSAAFVLQRSEVMLTG

--------------------------------------------------------------

>64741_64741_8_PHC3-FNDC3B_PHC3_chr3_169863210_ENST00000495893_FNDC3B_chr3_172114953_ENST00000415807_length(amino acids)=327AA_BP=224
MAEAEFKDHSTAMDTEPNPGTSSVSTTTSSTTTTTITTSSSRMQQPQISVYSGSDRHAVQVIQQALHRPPSSAAQYLQQMYAAQQQHLML
HTAALQQQHLSSSQLQSLAAVQASLSSGRPSTSPTGSVTQQSSMSQTSINLSTSPTPAQLISRSQASSSTSGSITQQTMLLGSTSPTLTA
SQAQMYLRAQMLIFTPATTVAAVQSDIPVVSSSSSSSCQSAATQVYKGEEATFQISGLQTNTDYRFRVCACRRCLDTSQELSGAFSPSAA

--------------------------------------------------------------

>64741_64741_9_PHC3-FNDC3B_PHC3_chr3_169863210_ENST00000495893_FNDC3B_chr3_172114953_ENST00000416957_length(amino acids)=327AA_BP=224
MAEAEFKDHSTAMDTEPNPGTSSVSTTTSSTTTTTITTSSSRMQQPQISVYSGSDRHAVQVIQQALHRPPSSAAQYLQQMYAAQQQHLML
HTAALQQQHLSSSQLQSLAAVQASLSSGRPSTSPTGSVTQQSSMSQTSINLSTSPTPAQLISRSQASSSTSGSITQQTMLLGSTSPTLTA
SQAQMYLRAQMLIFTPATTVAAVQSDIPVVSSSSSSSCQSAATQVYKGEEATFQISGLQTNTDYRFRVCACRRCLDTSQELSGAFSPSAA

--------------------------------------------------------------

>64741_64741_10_PHC3-FNDC3B_PHC3_chr3_169863211_ENST00000467570_FNDC3B_chr3_172114954_ENST00000415807_length(amino acids)=274AA_BP=171
MAEAEFKDHSTAMDTEPNPGTSSVSTTTSSTTTTTITTSSSRMQQPQISVYSGSDRHAVQVIQQALHRPPSSAAQYLQQMYAAQQQHLML
HTAALQQQHLSSSQLQSLAAVQASLSSGRPSTSPTGSVTQQSSMSQTSLIFTPATTVAAVQSDIPVVSSSSSSSCQSAATQVYKGEEATF
QISGLQTNTDYRFRVCACRRCLDTSQELSGAFSPSAAFVLQRSEVMLTGDMGSLDDPKMKSMMPTDEQFAAIIVLGFATLSILFAFILQY

--------------------------------------------------------------

>64741_64741_11_PHC3-FNDC3B_PHC3_chr3_169863211_ENST00000467570_FNDC3B_chr3_172114954_ENST00000416957_length(amino acids)=274AA_BP=171
MAEAEFKDHSTAMDTEPNPGTSSVSTTTSSTTTTTITTSSSRMQQPQISVYSGSDRHAVQVIQQALHRPPSSAAQYLQQMYAAQQQHLML
HTAALQQQHLSSSQLQSLAAVQASLSSGRPSTSPTGSVTQQSSMSQTSLIFTPATTVAAVQSDIPVVSSSSSSSCQSAATQVYKGEEATF
QISGLQTNTDYRFRVCACRRCLDTSQELSGAFSPSAAFVLQRSEVMLTGDMGSLDDPKMKSMMPTDEQFAAIIVLGFATLSILFAFILQY

--------------------------------------------------------------

>64741_64741_12_PHC3-FNDC3B_PHC3_chr3_169863211_ENST00000494943_FNDC3B_chr3_172114954_ENST00000415807_length(amino acids)=315AA_BP=212
MDTEPNPGTSSVSTTTSSTTTTTITTSSSRMQQPQISVYSGSDRHAVQVIQQALHRPPSSAAQYLQQMYAAQQQHLMLHTAALQQQHLSS
SQLQSLAAVQASLSSGRPSTSPTGSVTQQSSMSQTSINLSTSPTPAQLISRSQASSSTSGSITQQTMLLGSTSPTLTASQAQMYLRAQML
IFTPATTVAAVQSDIPVVSSSSSSSCQSAATQVYKGEEATFQISGLQTNTDYRFRVCACRRCLDTSQELSGAFSPSAAFVLQRSEVMLTG

--------------------------------------------------------------

>64741_64741_13_PHC3-FNDC3B_PHC3_chr3_169863211_ENST00000494943_FNDC3B_chr3_172114954_ENST00000416957_length(amino acids)=315AA_BP=212
MDTEPNPGTSSVSTTTSSTTTTTITTSSSRMQQPQISVYSGSDRHAVQVIQQALHRPPSSAAQYLQQMYAAQQQHLMLHTAALQQQHLSS
SQLQSLAAVQASLSSGRPSTSPTGSVTQQSSMSQTSINLSTSPTPAQLISRSQASSSTSGSITQQTMLLGSTSPTLTASQAQMYLRAQML
IFTPATTVAAVQSDIPVVSSSSSSSCQSAATQVYKGEEATFQISGLQTNTDYRFRVCACRRCLDTSQELSGAFSPSAAFVLQRSEVMLTG

--------------------------------------------------------------

>64741_64741_14_PHC3-FNDC3B_PHC3_chr3_169863211_ENST00000495893_FNDC3B_chr3_172114954_ENST00000415807_length(amino acids)=327AA_BP=224
MAEAEFKDHSTAMDTEPNPGTSSVSTTTSSTTTTTITTSSSRMQQPQISVYSGSDRHAVQVIQQALHRPPSSAAQYLQQMYAAQQQHLML
HTAALQQQHLSSSQLQSLAAVQASLSSGRPSTSPTGSVTQQSSMSQTSINLSTSPTPAQLISRSQASSSTSGSITQQTMLLGSTSPTLTA
SQAQMYLRAQMLIFTPATTVAAVQSDIPVVSSSSSSSCQSAATQVYKGEEATFQISGLQTNTDYRFRVCACRRCLDTSQELSGAFSPSAA

--------------------------------------------------------------

>64741_64741_15_PHC3-FNDC3B_PHC3_chr3_169863211_ENST00000495893_FNDC3B_chr3_172114954_ENST00000416957_length(amino acids)=327AA_BP=224
MAEAEFKDHSTAMDTEPNPGTSSVSTTTSSTTTTTITTSSSRMQQPQISVYSGSDRHAVQVIQQALHRPPSSAAQYLQQMYAAQQQHLML
HTAALQQQHLSSSQLQSLAAVQASLSSGRPSTSPTGSVTQQSSMSQTSINLSTSPTPAQLISRSQASSSTSGSITQQTMLLGSTSPTLTA
SQAQMYLRAQMLIFTPATTVAAVQSDIPVVSSSSSSSCQSAATQVYKGEEATFQISGLQTNTDYRFRVCACRRCLDTSQELSGAFSPSAA

--------------------------------------------------------------

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr3:169831148/chr3:172114954)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.FNDC3B

Q53EP0

FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: May be a positive regulator of adipogenesis. {ECO:0000269|PubMed:15564382}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

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* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePHC3chr3:169831148chr3:172114954ENST00000494943-111519_26772.3333333333334984.0Compositional biasNote=Poly-Thr
HgenePHC3chr3:169831148chr3:172114954ENST00000494943-1115324_539772.3333333333334984.0Compositional biasNote=Gln-rich
HgenePHC3chr3:169831148chr3:172114954ENST00000494943-1115346_670772.3333333333334984.0Compositional biasNote=Pro-rich
HgenePHC3chr3:169831148chr3:172114954ENST00000494943-111589_287772.3333333333334984.0Compositional biasNote=Ser-rich
HgenePHC3chr3:169831148chr3:172114954ENST00000495893-111519_26784.3333333333334996.0Compositional biasNote=Poly-Thr
HgenePHC3chr3:169831148chr3:172114954ENST00000495893-1115324_539784.3333333333334996.0Compositional biasNote=Gln-rich
HgenePHC3chr3:169831148chr3:172114954ENST00000495893-1115346_670784.3333333333334996.0Compositional biasNote=Pro-rich
HgenePHC3chr3:169831148chr3:172114954ENST00000495893-111589_287784.3333333333334996.0Compositional biasNote=Ser-rich
HgenePHC3chr3:169863210chr3:172114953ENST00000494943-61519_26212.0984.0Compositional biasNote=Poly-Thr
HgenePHC3chr3:169863210chr3:172114953ENST00000495893-61519_26224.0996.0Compositional biasNote=Poly-Thr
HgenePHC3chr3:169863211chr3:172114954ENST00000494943-61519_26212.0984.0Compositional biasNote=Poly-Thr
HgenePHC3chr3:169863211chr3:172114954ENST00000495893-61519_26224.0996.0Compositional biasNote=Poly-Thr
HgenePHC3chr3:169831148chr3:172114954ENST00000494943-1115691_720772.3333333333334984.0MotifNote=HD1
HgenePHC3chr3:169831148chr3:172114954ENST00000495893-1115691_720784.3333333333334996.0MotifNote=HD1
TgeneFNDC3Bchr3:169831148chr3:172114954ENST0000042175704231_243072.0Compositional biasNote=Poly-Gly
TgeneFNDC3Bchr3:169831148chr3:172114954ENST0000042342404231_243072.0Compositional biasNote=Poly-Gly
TgeneFNDC3Bchr3:169863210chr3:172114953ENST0000042175704231_243072.0Compositional biasNote=Poly-Gly
TgeneFNDC3Bchr3:169863210chr3:172114953ENST0000042342404231_243072.0Compositional biasNote=Poly-Gly
TgeneFNDC3Bchr3:169863211chr3:172114954ENST0000042175704231_243072.0Compositional biasNote=Poly-Gly
TgeneFNDC3Bchr3:169863211chr3:172114954ENST0000042342404231_243072.0Compositional biasNote=Poly-Gly
TgeneFNDC3Bchr3:169831148chr3:172114954ENST00000421757041056_1153072.0DomainFibronectin type-III 9
TgeneFNDC3Bchr3:169831148chr3:172114954ENST0000042175704278_377072.0DomainFibronectin type-III 1
TgeneFNDC3Bchr3:169831148chr3:172114954ENST0000042175704381_473072.0DomainFibronectin type-III 2
TgeneFNDC3Bchr3:169831148chr3:172114954ENST0000042175704477_570072.0DomainFibronectin type-III 3
TgeneFNDC3Bchr3:169831148chr3:172114954ENST0000042175704574_669072.0DomainFibronectin type-III 4
TgeneFNDC3Bchr3:169831148chr3:172114954ENST0000042175704673_765072.0DomainFibronectin type-III 5
TgeneFNDC3Bchr3:169831148chr3:172114954ENST0000042175704766_859072.0DomainFibronectin type-III 6
TgeneFNDC3Bchr3:169831148chr3:172114954ENST0000042175704871_957072.0DomainFibronectin type-III 7
TgeneFNDC3Bchr3:169831148chr3:172114954ENST0000042175704958_1052072.0DomainFibronectin type-III 8
TgeneFNDC3Bchr3:169831148chr3:172114954ENST00000423424041056_1153072.0DomainFibronectin type-III 9
TgeneFNDC3Bchr3:169831148chr3:172114954ENST0000042342404278_377072.0DomainFibronectin type-III 1
TgeneFNDC3Bchr3:169831148chr3:172114954ENST0000042342404381_473072.0DomainFibronectin type-III 2
TgeneFNDC3Bchr3:169831148chr3:172114954ENST0000042342404477_570072.0DomainFibronectin type-III 3
TgeneFNDC3Bchr3:169831148chr3:172114954ENST0000042342404574_669072.0DomainFibronectin type-III 4
TgeneFNDC3Bchr3:169831148chr3:172114954ENST0000042342404673_765072.0DomainFibronectin type-III 5
TgeneFNDC3Bchr3:169831148chr3:172114954ENST0000042342404766_859072.0DomainFibronectin type-III 6
TgeneFNDC3Bchr3:169831148chr3:172114954ENST0000042342404871_957072.0DomainFibronectin type-III 7
TgeneFNDC3Bchr3:169831148chr3:172114954ENST0000042342404958_1052072.0DomainFibronectin type-III 8
TgeneFNDC3Bchr3:169863210chr3:172114953ENST00000421757041056_1153072.0DomainFibronectin type-III 9
TgeneFNDC3Bchr3:169863210chr3:172114953ENST0000042175704278_377072.0DomainFibronectin type-III 1
TgeneFNDC3Bchr3:169863210chr3:172114953ENST0000042175704381_473072.0DomainFibronectin type-III 2
TgeneFNDC3Bchr3:169863210chr3:172114953ENST0000042175704477_570072.0DomainFibronectin type-III 3
TgeneFNDC3Bchr3:169863210chr3:172114953ENST0000042175704574_669072.0DomainFibronectin type-III 4
TgeneFNDC3Bchr3:169863210chr3:172114953ENST0000042175704673_765072.0DomainFibronectin type-III 5
TgeneFNDC3Bchr3:169863210chr3:172114953ENST0000042175704766_859072.0DomainFibronectin type-III 6
TgeneFNDC3Bchr3:169863210chr3:172114953ENST0000042175704871_957072.0DomainFibronectin type-III 7
TgeneFNDC3Bchr3:169863210chr3:172114953ENST0000042175704958_1052072.0DomainFibronectin type-III 8
TgeneFNDC3Bchr3:169863210chr3:172114953ENST00000423424041056_1153072.0DomainFibronectin type-III 9
TgeneFNDC3Bchr3:169863210chr3:172114953ENST0000042342404278_377072.0DomainFibronectin type-III 1
TgeneFNDC3Bchr3:169863210chr3:172114953ENST0000042342404381_473072.0DomainFibronectin type-III 2
TgeneFNDC3Bchr3:169863210chr3:172114953ENST0000042342404477_570072.0DomainFibronectin type-III 3
TgeneFNDC3Bchr3:169863210chr3:172114953ENST0000042342404574_669072.0DomainFibronectin type-III 4
TgeneFNDC3Bchr3:169863210chr3:172114953ENST0000042342404673_765072.0DomainFibronectin type-III 5
TgeneFNDC3Bchr3:169863210chr3:172114953ENST0000042342404766_859072.0DomainFibronectin type-III 6
TgeneFNDC3Bchr3:169863210chr3:172114953ENST0000042342404871_957072.0DomainFibronectin type-III 7
TgeneFNDC3Bchr3:169863210chr3:172114953ENST0000042342404958_1052072.0DomainFibronectin type-III 8
TgeneFNDC3Bchr3:169863211chr3:172114954ENST00000421757041056_1153072.0DomainFibronectin type-III 9
TgeneFNDC3Bchr3:169863211chr3:172114954ENST0000042175704278_377072.0DomainFibronectin type-III 1
TgeneFNDC3Bchr3:169863211chr3:172114954ENST0000042175704381_473072.0DomainFibronectin type-III 2
TgeneFNDC3Bchr3:169863211chr3:172114954ENST0000042175704477_570072.0DomainFibronectin type-III 3
TgeneFNDC3Bchr3:169863211chr3:172114954ENST0000042175704574_669072.0DomainFibronectin type-III 4
TgeneFNDC3Bchr3:169863211chr3:172114954ENST0000042175704673_765072.0DomainFibronectin type-III 5
TgeneFNDC3Bchr3:169863211chr3:172114954ENST0000042175704766_859072.0DomainFibronectin type-III 6
TgeneFNDC3Bchr3:169863211chr3:172114954ENST0000042175704871_957072.0DomainFibronectin type-III 7
TgeneFNDC3Bchr3:169863211chr3:172114954ENST0000042175704958_1052072.0DomainFibronectin type-III 8
TgeneFNDC3Bchr3:169863211chr3:172114954ENST00000423424041056_1153072.0DomainFibronectin type-III 9
TgeneFNDC3Bchr3:169863211chr3:172114954ENST0000042342404278_377072.0DomainFibronectin type-III 1
TgeneFNDC3Bchr3:169863211chr3:172114954ENST0000042342404381_473072.0DomainFibronectin type-III 2
TgeneFNDC3Bchr3:169863211chr3:172114954ENST0000042342404477_570072.0DomainFibronectin type-III 3
TgeneFNDC3Bchr3:169863211chr3:172114954ENST0000042342404574_669072.0DomainFibronectin type-III 4
TgeneFNDC3Bchr3:169863211chr3:172114954ENST0000042342404673_765072.0DomainFibronectin type-III 5
TgeneFNDC3Bchr3:169863211chr3:172114954ENST0000042342404766_859072.0DomainFibronectin type-III 6
TgeneFNDC3Bchr3:169863211chr3:172114954ENST0000042342404871_957072.0DomainFibronectin type-III 7
TgeneFNDC3Bchr3:169863211chr3:172114954ENST0000042342404958_1052072.0DomainFibronectin type-III 8
TgeneFNDC3Bchr3:169831148chr3:172114954ENST0000033682424261182_12021101.01205.0TransmembraneHelical
TgeneFNDC3Bchr3:169831148chr3:172114954ENST0000041580724261182_12021101.01205.0TransmembraneHelical
TgeneFNDC3Bchr3:169831148chr3:172114954ENST0000041695724261182_12021101.01205.0TransmembraneHelical
TgeneFNDC3Bchr3:169831148chr3:172114954ENST00000421757041182_1202072.0TransmembraneHelical
TgeneFNDC3Bchr3:169831148chr3:172114954ENST00000423424041182_1202072.0TransmembraneHelical
TgeneFNDC3Bchr3:169863210chr3:172114953ENST0000033682424261182_12021101.01205.0TransmembraneHelical
TgeneFNDC3Bchr3:169863210chr3:172114953ENST0000041580724261182_12021101.01205.0TransmembraneHelical
TgeneFNDC3Bchr3:169863210chr3:172114953ENST0000041695724261182_12021101.01205.0TransmembraneHelical
TgeneFNDC3Bchr3:169863210chr3:172114953ENST00000421757041182_1202072.0TransmembraneHelical
TgeneFNDC3Bchr3:169863210chr3:172114953ENST00000423424041182_1202072.0TransmembraneHelical
TgeneFNDC3Bchr3:169863211chr3:172114954ENST0000033682424261182_12021101.01205.0TransmembraneHelical
TgeneFNDC3Bchr3:169863211chr3:172114954ENST0000041580724261182_12021101.01205.0TransmembraneHelical
TgeneFNDC3Bchr3:169863211chr3:172114954ENST0000041695724261182_12021101.01205.0TransmembraneHelical
TgeneFNDC3Bchr3:169863211chr3:172114954ENST00000421757041182_1202072.0TransmembraneHelical
TgeneFNDC3Bchr3:169863211chr3:172114954ENST00000423424041182_1202072.0TransmembraneHelical

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePHC3chr3:169831148chr3:172114954ENST00000474275-1519_260187.0Compositional biasNote=Poly-Thr
HgenePHC3chr3:169831148chr3:172114954ENST00000474275-15324_5390187.0Compositional biasNote=Gln-rich
HgenePHC3chr3:169831148chr3:172114954ENST00000474275-15346_6700187.0Compositional biasNote=Pro-rich
HgenePHC3chr3:169831148chr3:172114954ENST00000474275-1589_2870187.0Compositional biasNote=Ser-rich
HgenePHC3chr3:169831148chr3:172114954ENST00000497658-1419_260152.0Compositional biasNote=Poly-Thr
HgenePHC3chr3:169831148chr3:172114954ENST00000497658-14324_5390152.0Compositional biasNote=Gln-rich
HgenePHC3chr3:169831148chr3:172114954ENST00000497658-14346_6700152.0Compositional biasNote=Pro-rich
HgenePHC3chr3:169831148chr3:172114954ENST00000497658-1489_2870152.0Compositional biasNote=Ser-rich
HgenePHC3chr3:169863210chr3:172114953ENST00000474275-1519_260187.0Compositional biasNote=Poly-Thr
HgenePHC3chr3:169863210chr3:172114953ENST00000474275-15324_5390187.0Compositional biasNote=Gln-rich
HgenePHC3chr3:169863210chr3:172114953ENST00000474275-15346_6700187.0Compositional biasNote=Pro-rich
HgenePHC3chr3:169863210chr3:172114953ENST00000474275-1589_2870187.0Compositional biasNote=Ser-rich
HgenePHC3chr3:169863210chr3:172114953ENST00000494943-615324_539212.0984.0Compositional biasNote=Gln-rich
HgenePHC3chr3:169863210chr3:172114953ENST00000494943-615346_670212.0984.0Compositional biasNote=Pro-rich
HgenePHC3chr3:169863210chr3:172114953ENST00000494943-61589_287212.0984.0Compositional biasNote=Ser-rich
HgenePHC3chr3:169863210chr3:172114953ENST00000495893-615324_539224.0996.0Compositional biasNote=Gln-rich
HgenePHC3chr3:169863210chr3:172114953ENST00000495893-615346_670224.0996.0Compositional biasNote=Pro-rich
HgenePHC3chr3:169863210chr3:172114953ENST00000495893-61589_287224.0996.0Compositional biasNote=Ser-rich
HgenePHC3chr3:169863210chr3:172114953ENST00000497658-1419_260152.0Compositional biasNote=Poly-Thr
HgenePHC3chr3:169863210chr3:172114953ENST00000497658-14324_5390152.0Compositional biasNote=Gln-rich
HgenePHC3chr3:169863210chr3:172114953ENST00000497658-14346_6700152.0Compositional biasNote=Pro-rich
HgenePHC3chr3:169863210chr3:172114953ENST00000497658-1489_2870152.0Compositional biasNote=Ser-rich
HgenePHC3chr3:169863211chr3:172114954ENST00000474275-1519_260187.0Compositional biasNote=Poly-Thr
HgenePHC3chr3:169863211chr3:172114954ENST00000474275-15324_5390187.0Compositional biasNote=Gln-rich
HgenePHC3chr3:169863211chr3:172114954ENST00000474275-15346_6700187.0Compositional biasNote=Pro-rich
HgenePHC3chr3:169863211chr3:172114954ENST00000474275-1589_2870187.0Compositional biasNote=Ser-rich
HgenePHC3chr3:169863211chr3:172114954ENST00000494943-615324_539212.0984.0Compositional biasNote=Gln-rich
HgenePHC3chr3:169863211chr3:172114954ENST00000494943-615346_670212.0984.0Compositional biasNote=Pro-rich
HgenePHC3chr3:169863211chr3:172114954ENST00000494943-61589_287212.0984.0Compositional biasNote=Ser-rich
HgenePHC3chr3:169863211chr3:172114954ENST00000495893-615324_539224.0996.0Compositional biasNote=Gln-rich
HgenePHC3chr3:169863211chr3:172114954ENST00000495893-615346_670224.0996.0Compositional biasNote=Pro-rich
HgenePHC3chr3:169863211chr3:172114954ENST00000495893-61589_287224.0996.0Compositional biasNote=Ser-rich
HgenePHC3chr3:169863211chr3:172114954ENST00000497658-1419_260152.0Compositional biasNote=Poly-Thr
HgenePHC3chr3:169863211chr3:172114954ENST00000497658-14324_5390152.0Compositional biasNote=Gln-rich
HgenePHC3chr3:169863211chr3:172114954ENST00000497658-14346_6700152.0Compositional biasNote=Pro-rich
HgenePHC3chr3:169863211chr3:172114954ENST00000497658-1489_2870152.0Compositional biasNote=Ser-rich
HgenePHC3chr3:169831148chr3:172114954ENST00000474275-15919_9830187.0DomainSAM
HgenePHC3chr3:169831148chr3:172114954ENST00000494943-1115919_983772.3333333333334984.0DomainSAM
HgenePHC3chr3:169831148chr3:172114954ENST00000495893-1115919_983784.3333333333334996.0DomainSAM
HgenePHC3chr3:169831148chr3:172114954ENST00000497658-14919_9830152.0DomainSAM
HgenePHC3chr3:169863210chr3:172114953ENST00000474275-15919_9830187.0DomainSAM
HgenePHC3chr3:169863210chr3:172114953ENST00000494943-615919_983212.0984.0DomainSAM
HgenePHC3chr3:169863210chr3:172114953ENST00000495893-615919_983224.0996.0DomainSAM
HgenePHC3chr3:169863210chr3:172114953ENST00000497658-14919_9830152.0DomainSAM
HgenePHC3chr3:169863211chr3:172114954ENST00000474275-15919_9830187.0DomainSAM
HgenePHC3chr3:169863211chr3:172114954ENST00000494943-615919_983212.0984.0DomainSAM
HgenePHC3chr3:169863211chr3:172114954ENST00000495893-615919_983224.0996.0DomainSAM
HgenePHC3chr3:169863211chr3:172114954ENST00000497658-14919_9830152.0DomainSAM
HgenePHC3chr3:169831148chr3:172114954ENST00000474275-15691_7200187.0MotifNote=HD1
HgenePHC3chr3:169831148chr3:172114954ENST00000497658-14691_7200152.0MotifNote=HD1
HgenePHC3chr3:169863210chr3:172114953ENST00000474275-15691_7200187.0MotifNote=HD1
HgenePHC3chr3:169863210chr3:172114953ENST00000494943-615691_720212.0984.0MotifNote=HD1
HgenePHC3chr3:169863210chr3:172114953ENST00000495893-615691_720224.0996.0MotifNote=HD1
HgenePHC3chr3:169863210chr3:172114953ENST00000497658-14691_7200152.0MotifNote=HD1
HgenePHC3chr3:169863211chr3:172114954ENST00000474275-15691_7200187.0MotifNote=HD1
HgenePHC3chr3:169863211chr3:172114954ENST00000494943-615691_720212.0984.0MotifNote=HD1
HgenePHC3chr3:169863211chr3:172114954ENST00000495893-615691_720224.0996.0MotifNote=HD1
HgenePHC3chr3:169863211chr3:172114954ENST00000497658-14691_7200152.0MotifNote=HD1
HgenePHC3chr3:169831148chr3:172114954ENST00000474275-15776_8100187.0Zinc fingerFCS-type
HgenePHC3chr3:169831148chr3:172114954ENST00000494943-1115776_810772.3333333333334984.0Zinc fingerFCS-type
HgenePHC3chr3:169831148chr3:172114954ENST00000495893-1115776_810784.3333333333334996.0Zinc fingerFCS-type
HgenePHC3chr3:169831148chr3:172114954ENST00000497658-14776_8100152.0Zinc fingerFCS-type
HgenePHC3chr3:169863210chr3:172114953ENST00000474275-15776_8100187.0Zinc fingerFCS-type
HgenePHC3chr3:169863210chr3:172114953ENST00000494943-615776_810212.0984.0Zinc fingerFCS-type
HgenePHC3chr3:169863210chr3:172114953ENST00000495893-615776_810224.0996.0Zinc fingerFCS-type
HgenePHC3chr3:169863210chr3:172114953ENST00000497658-14776_8100152.0Zinc fingerFCS-type
HgenePHC3chr3:169863211chr3:172114954ENST00000474275-15776_8100187.0Zinc fingerFCS-type
HgenePHC3chr3:169863211chr3:172114954ENST00000494943-615776_810212.0984.0Zinc fingerFCS-type
HgenePHC3chr3:169863211chr3:172114954ENST00000495893-615776_810224.0996.0Zinc fingerFCS-type
HgenePHC3chr3:169863211chr3:172114954ENST00000497658-14776_8100152.0Zinc fingerFCS-type
TgeneFNDC3Bchr3:169831148chr3:172114954ENST000003368242426231_2431101.01205.0Compositional biasNote=Poly-Gly
TgeneFNDC3Bchr3:169831148chr3:172114954ENST000004158072426231_2431101.01205.0Compositional biasNote=Poly-Gly
TgeneFNDC3Bchr3:169831148chr3:172114954ENST000004169572426231_2431101.01205.0Compositional biasNote=Poly-Gly
TgeneFNDC3Bchr3:169863210chr3:172114953ENST000003368242426231_2431101.01205.0Compositional biasNote=Poly-Gly
TgeneFNDC3Bchr3:169863210chr3:172114953ENST000004158072426231_2431101.01205.0Compositional biasNote=Poly-Gly
TgeneFNDC3Bchr3:169863210chr3:172114953ENST000004169572426231_2431101.01205.0Compositional biasNote=Poly-Gly
TgeneFNDC3Bchr3:169863211chr3:172114954ENST000003368242426231_2431101.01205.0Compositional biasNote=Poly-Gly
TgeneFNDC3Bchr3:169863211chr3:172114954ENST000004158072426231_2431101.01205.0Compositional biasNote=Poly-Gly
TgeneFNDC3Bchr3:169863211chr3:172114954ENST000004169572426231_2431101.01205.0Compositional biasNote=Poly-Gly
TgeneFNDC3Bchr3:169831148chr3:172114954ENST0000033682424261056_11531101.01205.0DomainFibronectin type-III 9
TgeneFNDC3Bchr3:169831148chr3:172114954ENST000003368242426278_3771101.01205.0DomainFibronectin type-III 1
TgeneFNDC3Bchr3:169831148chr3:172114954ENST000003368242426381_4731101.01205.0DomainFibronectin type-III 2
TgeneFNDC3Bchr3:169831148chr3:172114954ENST000003368242426477_5701101.01205.0DomainFibronectin type-III 3
TgeneFNDC3Bchr3:169831148chr3:172114954ENST000003368242426574_6691101.01205.0DomainFibronectin type-III 4
TgeneFNDC3Bchr3:169831148chr3:172114954ENST000003368242426673_7651101.01205.0DomainFibronectin type-III 5
TgeneFNDC3Bchr3:169831148chr3:172114954ENST000003368242426766_8591101.01205.0DomainFibronectin type-III 6
TgeneFNDC3Bchr3:169831148chr3:172114954ENST000003368242426871_9571101.01205.0DomainFibronectin type-III 7
TgeneFNDC3Bchr3:169831148chr3:172114954ENST000003368242426958_10521101.01205.0DomainFibronectin type-III 8
TgeneFNDC3Bchr3:169831148chr3:172114954ENST0000041580724261056_11531101.01205.0DomainFibronectin type-III 9
TgeneFNDC3Bchr3:169831148chr3:172114954ENST000004158072426278_3771101.01205.0DomainFibronectin type-III 1
TgeneFNDC3Bchr3:169831148chr3:172114954ENST000004158072426381_4731101.01205.0DomainFibronectin type-III 2
TgeneFNDC3Bchr3:169831148chr3:172114954ENST000004158072426477_5701101.01205.0DomainFibronectin type-III 3
TgeneFNDC3Bchr3:169831148chr3:172114954ENST000004158072426574_6691101.01205.0DomainFibronectin type-III 4
TgeneFNDC3Bchr3:169831148chr3:172114954ENST000004158072426673_7651101.01205.0DomainFibronectin type-III 5
TgeneFNDC3Bchr3:169831148chr3:172114954ENST000004158072426766_8591101.01205.0DomainFibronectin type-III 6
TgeneFNDC3Bchr3:169831148chr3:172114954ENST000004158072426871_9571101.01205.0DomainFibronectin type-III 7
TgeneFNDC3Bchr3:169831148chr3:172114954ENST000004158072426958_10521101.01205.0DomainFibronectin type-III 8
TgeneFNDC3Bchr3:169831148chr3:172114954ENST0000041695724261056_11531101.01205.0DomainFibronectin type-III 9
TgeneFNDC3Bchr3:169831148chr3:172114954ENST000004169572426278_3771101.01205.0DomainFibronectin type-III 1
TgeneFNDC3Bchr3:169831148chr3:172114954ENST000004169572426381_4731101.01205.0DomainFibronectin type-III 2
TgeneFNDC3Bchr3:169831148chr3:172114954ENST000004169572426477_5701101.01205.0DomainFibronectin type-III 3
TgeneFNDC3Bchr3:169831148chr3:172114954ENST000004169572426574_6691101.01205.0DomainFibronectin type-III 4
TgeneFNDC3Bchr3:169831148chr3:172114954ENST000004169572426673_7651101.01205.0DomainFibronectin type-III 5
TgeneFNDC3Bchr3:169831148chr3:172114954ENST000004169572426766_8591101.01205.0DomainFibronectin type-III 6
TgeneFNDC3Bchr3:169831148chr3:172114954ENST000004169572426871_9571101.01205.0DomainFibronectin type-III 7
TgeneFNDC3Bchr3:169831148chr3:172114954ENST000004169572426958_10521101.01205.0DomainFibronectin type-III 8
TgeneFNDC3Bchr3:169863210chr3:172114953ENST0000033682424261056_11531101.01205.0DomainFibronectin type-III 9
TgeneFNDC3Bchr3:169863210chr3:172114953ENST000003368242426278_3771101.01205.0DomainFibronectin type-III 1
TgeneFNDC3Bchr3:169863210chr3:172114953ENST000003368242426381_4731101.01205.0DomainFibronectin type-III 2
TgeneFNDC3Bchr3:169863210chr3:172114953ENST000003368242426477_5701101.01205.0DomainFibronectin type-III 3
TgeneFNDC3Bchr3:169863210chr3:172114953ENST000003368242426574_6691101.01205.0DomainFibronectin type-III 4
TgeneFNDC3Bchr3:169863210chr3:172114953ENST000003368242426673_7651101.01205.0DomainFibronectin type-III 5
TgeneFNDC3Bchr3:169863210chr3:172114953ENST000003368242426766_8591101.01205.0DomainFibronectin type-III 6
TgeneFNDC3Bchr3:169863210chr3:172114953ENST000003368242426871_9571101.01205.0DomainFibronectin type-III 7
TgeneFNDC3Bchr3:169863210chr3:172114953ENST000003368242426958_10521101.01205.0DomainFibronectin type-III 8
TgeneFNDC3Bchr3:169863210chr3:172114953ENST0000041580724261056_11531101.01205.0DomainFibronectin type-III 9
TgeneFNDC3Bchr3:169863210chr3:172114953ENST000004158072426278_3771101.01205.0DomainFibronectin type-III 1
TgeneFNDC3Bchr3:169863210chr3:172114953ENST000004158072426381_4731101.01205.0DomainFibronectin type-III 2
TgeneFNDC3Bchr3:169863210chr3:172114953ENST000004158072426477_5701101.01205.0DomainFibronectin type-III 3
TgeneFNDC3Bchr3:169863210chr3:172114953ENST000004158072426574_6691101.01205.0DomainFibronectin type-III 4
TgeneFNDC3Bchr3:169863210chr3:172114953ENST000004158072426673_7651101.01205.0DomainFibronectin type-III 5
TgeneFNDC3Bchr3:169863210chr3:172114953ENST000004158072426766_8591101.01205.0DomainFibronectin type-III 6
TgeneFNDC3Bchr3:169863210chr3:172114953ENST000004158072426871_9571101.01205.0DomainFibronectin type-III 7
TgeneFNDC3Bchr3:169863210chr3:172114953ENST000004158072426958_10521101.01205.0DomainFibronectin type-III 8
TgeneFNDC3Bchr3:169863210chr3:172114953ENST0000041695724261056_11531101.01205.0DomainFibronectin type-III 9
TgeneFNDC3Bchr3:169863210chr3:172114953ENST000004169572426278_3771101.01205.0DomainFibronectin type-III 1
TgeneFNDC3Bchr3:169863210chr3:172114953ENST000004169572426381_4731101.01205.0DomainFibronectin type-III 2
TgeneFNDC3Bchr3:169863210chr3:172114953ENST000004169572426477_5701101.01205.0DomainFibronectin type-III 3
TgeneFNDC3Bchr3:169863210chr3:172114953ENST000004169572426574_6691101.01205.0DomainFibronectin type-III 4
TgeneFNDC3Bchr3:169863210chr3:172114953ENST000004169572426673_7651101.01205.0DomainFibronectin type-III 5
TgeneFNDC3Bchr3:169863210chr3:172114953ENST000004169572426766_8591101.01205.0DomainFibronectin type-III 6
TgeneFNDC3Bchr3:169863210chr3:172114953ENST000004169572426871_9571101.01205.0DomainFibronectin type-III 7
TgeneFNDC3Bchr3:169863210chr3:172114953ENST000004169572426958_10521101.01205.0DomainFibronectin type-III 8
TgeneFNDC3Bchr3:169863211chr3:172114954ENST0000033682424261056_11531101.01205.0DomainFibronectin type-III 9
TgeneFNDC3Bchr3:169863211chr3:172114954ENST000003368242426278_3771101.01205.0DomainFibronectin type-III 1
TgeneFNDC3Bchr3:169863211chr3:172114954ENST000003368242426381_4731101.01205.0DomainFibronectin type-III 2
TgeneFNDC3Bchr3:169863211chr3:172114954ENST000003368242426477_5701101.01205.0DomainFibronectin type-III 3
TgeneFNDC3Bchr3:169863211chr3:172114954ENST000003368242426574_6691101.01205.0DomainFibronectin type-III 4
TgeneFNDC3Bchr3:169863211chr3:172114954ENST000003368242426673_7651101.01205.0DomainFibronectin type-III 5
TgeneFNDC3Bchr3:169863211chr3:172114954ENST000003368242426766_8591101.01205.0DomainFibronectin type-III 6
TgeneFNDC3Bchr3:169863211chr3:172114954ENST000003368242426871_9571101.01205.0DomainFibronectin type-III 7
TgeneFNDC3Bchr3:169863211chr3:172114954ENST000003368242426958_10521101.01205.0DomainFibronectin type-III 8
TgeneFNDC3Bchr3:169863211chr3:172114954ENST0000041580724261056_11531101.01205.0DomainFibronectin type-III 9
TgeneFNDC3Bchr3:169863211chr3:172114954ENST000004158072426278_3771101.01205.0DomainFibronectin type-III 1
TgeneFNDC3Bchr3:169863211chr3:172114954ENST000004158072426381_4731101.01205.0DomainFibronectin type-III 2
TgeneFNDC3Bchr3:169863211chr3:172114954ENST000004158072426477_5701101.01205.0DomainFibronectin type-III 3
TgeneFNDC3Bchr3:169863211chr3:172114954ENST000004158072426574_6691101.01205.0DomainFibronectin type-III 4
TgeneFNDC3Bchr3:169863211chr3:172114954ENST000004158072426673_7651101.01205.0DomainFibronectin type-III 5
TgeneFNDC3Bchr3:169863211chr3:172114954ENST000004158072426766_8591101.01205.0DomainFibronectin type-III 6
TgeneFNDC3Bchr3:169863211chr3:172114954ENST000004158072426871_9571101.01205.0DomainFibronectin type-III 7
TgeneFNDC3Bchr3:169863211chr3:172114954ENST000004158072426958_10521101.01205.0DomainFibronectin type-III 8
TgeneFNDC3Bchr3:169863211chr3:172114954ENST0000041695724261056_11531101.01205.0DomainFibronectin type-III 9
TgeneFNDC3Bchr3:169863211chr3:172114954ENST000004169572426278_3771101.01205.0DomainFibronectin type-III 1
TgeneFNDC3Bchr3:169863211chr3:172114954ENST000004169572426381_4731101.01205.0DomainFibronectin type-III 2
TgeneFNDC3Bchr3:169863211chr3:172114954ENST000004169572426477_5701101.01205.0DomainFibronectin type-III 3
TgeneFNDC3Bchr3:169863211chr3:172114954ENST000004169572426574_6691101.01205.0DomainFibronectin type-III 4
TgeneFNDC3Bchr3:169863211chr3:172114954ENST000004169572426673_7651101.01205.0DomainFibronectin type-III 5
TgeneFNDC3Bchr3:169863211chr3:172114954ENST000004169572426766_8591101.01205.0DomainFibronectin type-III 6
TgeneFNDC3Bchr3:169863211chr3:172114954ENST000004169572426871_9571101.01205.0DomainFibronectin type-III 7
TgeneFNDC3Bchr3:169863211chr3:172114954ENST000004169572426958_10521101.01205.0DomainFibronectin type-III 8


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Fusion Protein Structures

check button PDB and CIF files of the predicted fusion proteins
* Here we show the 3D structure of the fusion proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format.
Fusion protein PDB link (fusion AA seq ID in FusionPDB)HgeneHchrHbpHstrandTgeneTchrTbpTstrandAA seqLen(AA seq)
PDB file >>>608_PHC3_169863211_FNDC3B_172114954_ranked_0.pdbPHC3169863210169863211ENST00000416957FNDC3Bchr3172114954+
MAEAEFKDHSTAMDTEPNPGTSSVSTTTSSTTTTTITTSSSRMQQPQISVYSGSDRHAVQVIQQALHRPPSSAAQYLQQMYAAQQQHLML
HTAALQQQHLSSSQLQSLAAVQASLSSGRPSTSPTGSVTQQSSMSQTSINLSTSPTPAQLISRSQASSSTSGSITQQTMLLGSTSPTLTA
SQAQMYLRAQMLIFTPATTVAAVQSDIPVVSSSSSSSCQSAATQVYKGEEATFQISGLQTNTDYRFRVCACRRCLDTSQELSGAFSPSAA
327


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pLDDT score distribution

check button pLDDT score distribution of the predicted wild-type structures of two partner proteins from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.
PHC3_pLDDT.png
all structure
all structure
FNDC3B_pLDDT.png
all structure
all structure

check button pLDDT score distribution of the predicted fusion protein structures from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.
all structure


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Ramachandran Plot of Fusion Protein Structure


check button Ramachandran plot of the torsional angles - phi (φ)and psi (ψ) - of the residues (amino acids) contained in this fusion protein peptide.
Fusion AA seq ID in FusionPDB and their Ramachandran plots

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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
PHC3
FNDC3B


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to PHC3-FNDC3B


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to PHC3-FNDC3B


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource