UTHEALTH HOME ABOUT SBMI A-Z WEBMAIL INSIDE THE UNIVERSITY

Home

Download

Statistics

Examples

Help

Contact

level1

	Fusion Gene Summary
	Fusion Gene Sample Information
	Fusion ORF Analysis
	Fusion Amino Acid Sequences
	Fusion Protein Functional Features
	Fusion Protein-Protein Interaction
	Related drugs with this fusion protein
	Related disease with this fusion protein

Fusion Protein:PHC3-GNA12

Fusion Protein Summary

Fusion gene summary

Fusion partner gene information	Fusion gene name: PHC3-GNA12
	FusionPDB ID: 64742
	FusionGDB2.0 ID: 64742
		Hgene	Tgene
	Gene symbol	PHC3	GNA12
	Gene ID	80012	2768
	Gene name	polyhomeotic homolog 3	G protein subunit alpha 12
	Synonyms	EDR3\|HPH3	NNX3\|RMP\|gep
	Cytomap	3q26.2	7p22.3-p22.2
	Type of gene	protein-coding	protein-coding
	Description	polyhomeotic-like protein 3early development regulator 3early development regulatory protein 3homolog of polyhomeotic 3polyhomeotic like 3	guanine nucleotide-binding protein subunit alpha-12WUGSC:H_GS165O14.2g alpha-12guanine nucleotide binding protein (G protein) alpha 12
	Modification date	20200313	20200313
	UniProtAcc	.	Q03113
Ensembl transtripts involved in fusion gene	ENST ids	ENST00000467570, ENST00000474275, ENST00000481639, ENST00000494943, ENST00000495893, ENST00000497658,	ENST00000396960, ENST00000407653, ENST00000407904, ENST00000491117, ENST00000275364, ENST00000544127,
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)	* DoF score	15 X 15 X 11=2475	7 X 6 X 4=168
	# samples	20	9
	** MAII score	log2(20/2475*10)=-3.62935662007961 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(9/168*10)=-0.900464326449086 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)	PubMed: PHC3 [Title/Abstract] AND GNA12 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)	GNA12(2883487)-PHC3(169896726), # samples:3 PHC3(169896561)-GNA12(2834777), # samples:1
Anticipated loss of major functional domain due to fusion event.	PHC3-GNA12 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. PHC3-GNA12 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. PHC3-GNA12 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. PHC3-GNA12 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. GNA12-PHC3 seems lost the major protein functional domain in Tgene partner, which is a epigenetic factor due to the frame-shifted ORF. GNA12-PHC3 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF. GNA12-PHC3 seems lost the major protein functional domain in Tgene partner, which is a tumor suppressor due to the frame-shifted ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Fusion gene breakpoints across PHC3 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across GNA12 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Top

Fusion Gene Sample Information

Fusion gene information from FusionGDB2.0.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	HNSC	TCGA-CQ-A4CA-01A	PHC3	chr3	169896561	-	GNA12	chr7	2834777	-

Top

Fusion ORF Analysis

Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000495893	PHC3	chr3	169896561	-	ENST00000275364	GNA12	chr7	2834777	-	4118	212	32	1048	338
ENST00000495893	PHC3	chr3	169896561	-	ENST00000544127	GNA12	chr7	2834777	-	1365	212	32	997	321
ENST00000494943	PHC3	chr3	169896561	-	ENST00000275364	GNA12	chr7	2834777	-	4119	213	69	1049	326
ENST00000494943	PHC3	chr3	169896561	-	ENST00000544127	GNA12	chr7	2834777	-	1366	213	69	998	309
ENST00000467570	PHC3	chr3	169896561	-	ENST00000275364	GNA12	chr7	2834777	-	4120	214	34	1050	338
ENST00000467570	PHC3	chr3	169896561	-	ENST00000544127	GNA12	chr7	2834777	-	1367	214	34	999	321
ENST00000474275	PHC3	chr3	169896561	-	ENST00000275364	GNA12	chr7	2834777	-	4114	208	64	1044	326
ENST00000474275	PHC3	chr3	169896561	-	ENST00000544127	GNA12	chr7	2834777	-	1361	208	64	993	309
ENST00000497658	PHC3	chr3	169896561	-	ENST00000275364	GNA12	chr7	2834777	-	4104	198	18	1034	338
ENST00000497658	PHC3	chr3	169896561	-	ENST00000544127	GNA12	chr7	2834777	-	1351	198	18	983	321
ENST00000481639	PHC3	chr3	169896561	-	ENST00000275364	GNA12	chr7	2834777	-	4118	212	32	1048	338
ENST00000481639	PHC3	chr3	169896561	-	ENST00000544127	GNA12	chr7	2834777	-	1365	212	32	997	321

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000495893	ENST00000275364	PHC3	chr3	169896561	-	GNA12	chr7	2834777	-	0.002777222	0.9972228
ENST00000495893	ENST00000544127	PHC3	chr3	169896561	-	GNA12	chr7	2834777	-	0.002979477	0.99702054
ENST00000494943	ENST00000275364	PHC3	chr3	169896561	-	GNA12	chr7	2834777	-	0.002912963	0.99708706
ENST00000494943	ENST00000544127	PHC3	chr3	169896561	-	GNA12	chr7	2834777	-	0.004936987	0.995063
ENST00000467570	ENST00000275364	PHC3	chr3	169896561	-	GNA12	chr7	2834777	-	0.002779749	0.9972203
ENST00000467570	ENST00000544127	PHC3	chr3	169896561	-	GNA12	chr7	2834777	-	0.00286479	0.99713516
ENST00000474275	ENST00000275364	PHC3	chr3	169896561	-	GNA12	chr7	2834777	-	0.002915667	0.9970843
ENST00000474275	ENST00000544127	PHC3	chr3	169896561	-	GNA12	chr7	2834777	-	0.004949862	0.99505013
ENST00000497658	ENST00000275364	PHC3	chr3	169896561	-	GNA12	chr7	2834777	-	0.002804017	0.99719596
ENST00000497658	ENST00000544127	PHC3	chr3	169896561	-	GNA12	chr7	2834777	-	0.003307398	0.99669254
ENST00000481639	ENST00000275364	PHC3	chr3	169896561	-	GNA12	chr7	2834777	-	0.002777222	0.9972228
ENST00000481639	ENST00000544127	PHC3	chr3	169896561	-	GNA12	chr7	2834777	-	0.002979477	0.99702054

Top

Fusion Amino Acid Sequences

For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>64742_64742_1_PHC3-GNA12_PHC3_chr3_169896561_ENST00000467570_GNA12_chr7_2834777_ENST00000275364_length(amino acids)=338AA_BP=60
MAEAEFKDHSTAMDTEPNPGTSSVSTTTSSTTTTTITTSSSRMQQPQISVYSGSDRHAVQGSRVLVDARDKLGIPWQYSENEKHGMFLMA
FENKAGLPVEPATFQLYVPALSALWRDSGIREAFSRRSEFQLGESVKYFLDNLDRIGQLNYFPSKQDILLARKATKGIVEHDFVIKKIPF
KMVDVGGQRSQRQKWFQCFDGITSILFMVSSSEYDQVLMEDRRTNRLVESMNIFETIVNNKLFFNVSIILFLNKMDLLVEKVKTVSIKKH

--------------------------------------------------------------

>64742_64742_2_PHC3-GNA12_PHC3_chr3_169896561_ENST00000467570_GNA12_chr7_2834777_ENST00000544127_length(amino acids)=321AA_BP=60
MAEAEFKDHSTAMDTEPNPGTSSVSTTTSSTTTTTITTSSSRMQQPQISVYSGSDRHAVQGSRVLVDARDKLGIPWQYSENEKHGMFLMA
FENKAGLPVEPATFQLYVPALSALWRDSGIREAFSRRSEFQLNYFPSKQDILLARKATKGIVEHDFVIKKIPFKMVDVGGQRSQRQKWFQ
CFDGITSILFMVSSSEYDQVLMEDRRTNRLVESMNIFETIVNNKLFFNVSIILFLNKMDLLVEKVKTVSIKKHFPDFRGDPHRLEDVQRY

--------------------------------------------------------------

>64742_64742_3_PHC3-GNA12_PHC3_chr3_169896561_ENST00000474275_GNA12_chr7_2834777_ENST00000275364_length(amino acids)=326AA_BP=48
MDTEPNPGTSSVSTTTSSTTTTTITTSSSRMQQPQISVYSGSDRHAVQGSRVLVDARDKLGIPWQYSENEKHGMFLMAFENKAGLPVEPA
TFQLYVPALSALWRDSGIREAFSRRSEFQLGESVKYFLDNLDRIGQLNYFPSKQDILLARKATKGIVEHDFVIKKIPFKMVDVGGQRSQR
QKWFQCFDGITSILFMVSSSEYDQVLMEDRRTNRLVESMNIFETIVNNKLFFNVSIILFLNKMDLLVEKVKTVSIKKHFPDFRGDPHRLE

--------------------------------------------------------------

>64742_64742_4_PHC3-GNA12_PHC3_chr3_169896561_ENST00000474275_GNA12_chr7_2834777_ENST00000544127_length(amino acids)=309AA_BP=48
MDTEPNPGTSSVSTTTSSTTTTTITTSSSRMQQPQISVYSGSDRHAVQGSRVLVDARDKLGIPWQYSENEKHGMFLMAFENKAGLPVEPA
TFQLYVPALSALWRDSGIREAFSRRSEFQLNYFPSKQDILLARKATKGIVEHDFVIKKIPFKMVDVGGQRSQRQKWFQCFDGITSILFMV
SSSEYDQVLMEDRRTNRLVESMNIFETIVNNKLFFNVSIILFLNKMDLLVEKVKTVSIKKHFPDFRGDPHRLEDVQRYLVQCFDRKRRNR

--------------------------------------------------------------

>64742_64742_5_PHC3-GNA12_PHC3_chr3_169896561_ENST00000481639_GNA12_chr7_2834777_ENST00000275364_length(amino acids)=338AA_BP=60
MAEAEFKDHSTAMDTEPNPGTSSVSTTTSSTTTTTITTSSSRMQQPQISVYSGSDRHAVQGSRVLVDARDKLGIPWQYSENEKHGMFLMA
FENKAGLPVEPATFQLYVPALSALWRDSGIREAFSRRSEFQLGESVKYFLDNLDRIGQLNYFPSKQDILLARKATKGIVEHDFVIKKIPF
KMVDVGGQRSQRQKWFQCFDGITSILFMVSSSEYDQVLMEDRRTNRLVESMNIFETIVNNKLFFNVSIILFLNKMDLLVEKVKTVSIKKH

--------------------------------------------------------------

>64742_64742_6_PHC3-GNA12_PHC3_chr3_169896561_ENST00000481639_GNA12_chr7_2834777_ENST00000544127_length(amino acids)=321AA_BP=60
MAEAEFKDHSTAMDTEPNPGTSSVSTTTSSTTTTTITTSSSRMQQPQISVYSGSDRHAVQGSRVLVDARDKLGIPWQYSENEKHGMFLMA
FENKAGLPVEPATFQLYVPALSALWRDSGIREAFSRRSEFQLNYFPSKQDILLARKATKGIVEHDFVIKKIPFKMVDVGGQRSQRQKWFQ
CFDGITSILFMVSSSEYDQVLMEDRRTNRLVESMNIFETIVNNKLFFNVSIILFLNKMDLLVEKVKTVSIKKHFPDFRGDPHRLEDVQRY

--------------------------------------------------------------

>64742_64742_7_PHC3-GNA12_PHC3_chr3_169896561_ENST00000494943_GNA12_chr7_2834777_ENST00000275364_length(amino acids)=326AA_BP=48
MDTEPNPGTSSVSTTTSSTTTTTITTSSSRMQQPQISVYSGSDRHAVQGSRVLVDARDKLGIPWQYSENEKHGMFLMAFENKAGLPVEPA
TFQLYVPALSALWRDSGIREAFSRRSEFQLGESVKYFLDNLDRIGQLNYFPSKQDILLARKATKGIVEHDFVIKKIPFKMVDVGGQRSQR
QKWFQCFDGITSILFMVSSSEYDQVLMEDRRTNRLVESMNIFETIVNNKLFFNVSIILFLNKMDLLVEKVKTVSIKKHFPDFRGDPHRLE

--------------------------------------------------------------

>64742_64742_8_PHC3-GNA12_PHC3_chr3_169896561_ENST00000494943_GNA12_chr7_2834777_ENST00000544127_length(amino acids)=309AA_BP=48
MDTEPNPGTSSVSTTTSSTTTTTITTSSSRMQQPQISVYSGSDRHAVQGSRVLVDARDKLGIPWQYSENEKHGMFLMAFENKAGLPVEPA
TFQLYVPALSALWRDSGIREAFSRRSEFQLNYFPSKQDILLARKATKGIVEHDFVIKKIPFKMVDVGGQRSQRQKWFQCFDGITSILFMV
SSSEYDQVLMEDRRTNRLVESMNIFETIVNNKLFFNVSIILFLNKMDLLVEKVKTVSIKKHFPDFRGDPHRLEDVQRYLVQCFDRKRRNR

--------------------------------------------------------------

>64742_64742_9_PHC3-GNA12_PHC3_chr3_169896561_ENST00000495893_GNA12_chr7_2834777_ENST00000275364_length(amino acids)=338AA_BP=60
MAEAEFKDHSTAMDTEPNPGTSSVSTTTSSTTTTTITTSSSRMQQPQISVYSGSDRHAVQGSRVLVDARDKLGIPWQYSENEKHGMFLMA
FENKAGLPVEPATFQLYVPALSALWRDSGIREAFSRRSEFQLGESVKYFLDNLDRIGQLNYFPSKQDILLARKATKGIVEHDFVIKKIPF
KMVDVGGQRSQRQKWFQCFDGITSILFMVSSSEYDQVLMEDRRTNRLVESMNIFETIVNNKLFFNVSIILFLNKMDLLVEKVKTVSIKKH

--------------------------------------------------------------

>64742_64742_10_PHC3-GNA12_PHC3_chr3_169896561_ENST00000495893_GNA12_chr7_2834777_ENST00000544127_length(amino acids)=321AA_BP=60
MAEAEFKDHSTAMDTEPNPGTSSVSTTTSSTTTTTITTSSSRMQQPQISVYSGSDRHAVQGSRVLVDARDKLGIPWQYSENEKHGMFLMA
FENKAGLPVEPATFQLYVPALSALWRDSGIREAFSRRSEFQLNYFPSKQDILLARKATKGIVEHDFVIKKIPFKMVDVGGQRSQRQKWFQ
CFDGITSILFMVSSSEYDQVLMEDRRTNRLVESMNIFETIVNNKLFFNVSIILFLNKMDLLVEKVKTVSIKKHFPDFRGDPHRLEDVQRY

--------------------------------------------------------------

>64742_64742_11_PHC3-GNA12_PHC3_chr3_169896561_ENST00000497658_GNA12_chr7_2834777_ENST00000275364_length(amino acids)=338AA_BP=60
MAEAEFKDHSTAMDTEPNPGTSSVSTTTSSTTTTTITTSSSRMQQPQISVYSGSDRHAVQGSRVLVDARDKLGIPWQYSENEKHGMFLMA
FENKAGLPVEPATFQLYVPALSALWRDSGIREAFSRRSEFQLGESVKYFLDNLDRIGQLNYFPSKQDILLARKATKGIVEHDFVIKKIPF
KMVDVGGQRSQRQKWFQCFDGITSILFMVSSSEYDQVLMEDRRTNRLVESMNIFETIVNNKLFFNVSIILFLNKMDLLVEKVKTVSIKKH

--------------------------------------------------------------

>64742_64742_12_PHC3-GNA12_PHC3_chr3_169896561_ENST00000497658_GNA12_chr7_2834777_ENST00000544127_length(amino acids)=321AA_BP=60
MAEAEFKDHSTAMDTEPNPGTSSVSTTTSSTTTTTITTSSSRMQQPQISVYSGSDRHAVQGSRVLVDARDKLGIPWQYSENEKHGMFLMA
FENKAGLPVEPATFQLYVPALSALWRDSGIREAFSRRSEFQLNYFPSKQDILLARKATKGIVEHDFVIKKIPFKMVDVGGQRSQRQKWFQ
CFDGITSILFMVSSSEYDQVLMEDRRTNRLVESMNIFETIVNNKLFFNVSIILFLNKMDLLVEKVKTVSIKKHFPDFRGDPHRLEDVQRY

--------------------------------------------------------------

Top

Fusion Protein Functional Features

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr3:2883487/chr7:169896726)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	GNA12 Q03113
FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.	FUNCTION: Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems (PubMed:22609986, PubMed:15525651, PubMed:15240885, PubMed:17565996, PubMed:12515866, PubMed:16787920, PubMed:16705036, PubMed:23762476, PubMed:27084452). Activates effector molecule RhoA by binding and activating RhoGEFs (ARHGEF12/LARG) (PubMed:15240885, PubMed:12515866, PubMed:16202387). GNA12-dependent Rho signaling subsequently regulates transcription factor AP-1 (activating protein-1) (By similarity). GNA12-dependent Rho signaling also regulates protein phosphatese 2A activation causing dephosphorylation of its target proteins (PubMed:15525651, PubMed:17565996). Promotes tumor cell invasion and metastasis by activating RhoA/ROCK signaling pathway and up-regulating proinflammatory cytokine production (PubMed:23762476, PubMed:16787920, PubMed:16705036, PubMed:27084452). Inhibits CDH1-mediated cell adhesion in process independent from Rho activation (PubMed:11976333, PubMed:16787920). Together with NAPA promotes CDH5 localization to plasma membrane (PubMed:15980433). May play a role in the control of cell migration through the TOR signaling cascade (PubMed:22609986). {ECO:0000250\|UniProtKB:P27600, ECO:0000269\|PubMed:11976333, ECO:0000269\|PubMed:12515866, ECO:0000269\|PubMed:15240885, ECO:0000269\|PubMed:15525651, ECO:0000269\|PubMed:15980433, ECO:0000269\|PubMed:16705036, ECO:0000269\|PubMed:16787920, ECO:0000269\|PubMed:17565996, ECO:0000269\|PubMed:22609986, ECO:0000269\|PubMed:23762476, ECO:0000269\|PubMed:27084452}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
* Minus value of BPloci means that the break pointn is located before the CDS.

- Retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

PHC3

chr3:169896561

chr7:2834777

ENST00000474275

19_26

48.0

187.0

Compositional bias

Note=Poly-Thr

Hgene

PHC3

chr3:169896561

chr7:2834777

ENST00000494943

19_26

48.0

984.0

Compositional bias

Note=Poly-Thr

Hgene

PHC3

chr3:169896561

chr7:2834777

ENST00000495893

19_26

60.0

996.0

Compositional bias

Note=Poly-Thr

Hgene

PHC3

chr3:169896561

chr7:2834777

ENST00000497658

19_26

60.0

152.0

Compositional bias

Note=Poly-Thr

Tgene

GNA12

chr3:169896561

chr7:2834777

ENST00000275364

202_205

103.0

382.0

Nucleotide binding

GTP

Tgene

GNA12

chr3:169896561

chr7:2834777

ENST00000275364

296_299

103.0

382.0

Nucleotide binding

GTP

Tgene

GNA12

chr3:169896561

chr7:2834777

ENST00000275364

200_208

103.0

382.0

Region

G2 motif

Tgene

GNA12

chr3:169896561

chr7:2834777

ENST00000275364

223_232

103.0

382.0

Region

G3 motif

Tgene

GNA12

chr3:169896561

chr7:2834777

ENST00000275364

292_299

103.0

382.0

Region

G4 motif

Tgene

GNA12

chr3:169896561

chr7:2834777

ENST00000275364

351_356

103.0

382.0

Region

G5 motif

- Not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

PHC3

chr3:169896561

chr7:2834777

ENST00000474275

324_539

48.0

187.0

Compositional bias

Note=Gln-rich

Hgene

PHC3

chr3:169896561

chr7:2834777

ENST00000474275

346_670

48.0

187.0

Compositional bias

Note=Pro-rich

Hgene

PHC3

chr3:169896561

chr7:2834777

ENST00000474275

89_287

48.0

187.0

Compositional bias

Note=Ser-rich

Hgene

PHC3

chr3:169896561

chr7:2834777

ENST00000494943

324_539

48.0

984.0

Compositional bias

Note=Gln-rich

Hgene

PHC3

chr3:169896561

chr7:2834777

ENST00000494943

346_670

48.0

984.0

Compositional bias

Note=Pro-rich

Hgene

PHC3

chr3:169896561

chr7:2834777

ENST00000494943

89_287

48.0

984.0

Compositional bias

Note=Ser-rich

Hgene

PHC3

chr3:169896561

chr7:2834777

ENST00000495893

324_539

60.0

996.0

Compositional bias

Note=Gln-rich

Hgene

PHC3

chr3:169896561

chr7:2834777

ENST00000495893

346_670

60.0

996.0

Compositional bias

Note=Pro-rich

Hgene

PHC3

chr3:169896561

chr7:2834777

ENST00000495893

89_287

60.0

996.0

Compositional bias

Note=Ser-rich

Hgene

PHC3

chr3:169896561

chr7:2834777

ENST00000497658

324_539

60.0

152.0

Compositional bias

Note=Gln-rich

Hgene

PHC3

chr3:169896561

chr7:2834777

ENST00000497658

346_670

60.0

152.0

Compositional bias

Note=Pro-rich

Hgene

PHC3

chr3:169896561

chr7:2834777

ENST00000497658

89_287

60.0

152.0

Compositional bias

Note=Ser-rich

Hgene

PHC3

chr3:169896561

chr7:2834777

ENST00000474275

919_983

48.0

187.0

Domain

SAM

Hgene

PHC3

chr3:169896561

chr7:2834777

ENST00000494943

919_983

48.0

984.0

Domain

SAM

Hgene

PHC3

chr3:169896561

chr7:2834777

ENST00000495893

919_983

60.0

996.0

Domain

SAM

Hgene

PHC3

chr3:169896561

chr7:2834777

ENST00000497658

919_983

60.0

152.0

Domain

SAM

Hgene

PHC3

chr3:169896561

chr7:2834777

ENST00000474275

691_720

48.0

187.0

Motif

Note=HD1

Hgene

PHC3

chr3:169896561

chr7:2834777

ENST00000494943

691_720

48.0

984.0

Motif

Note=HD1

Hgene

PHC3

chr3:169896561

chr7:2834777

ENST00000495893

691_720

60.0

996.0

Motif

Note=HD1

Hgene

PHC3

chr3:169896561

chr7:2834777

ENST00000497658

691_720

60.0

152.0

Motif

Note=HD1

Hgene

PHC3

chr3:169896561

chr7:2834777

ENST00000474275

776_810

48.0

187.0

Zinc finger

FCS-type

Hgene

PHC3

chr3:169896561

chr7:2834777

ENST00000494943

776_810

48.0

984.0

Zinc finger

FCS-type

Hgene

PHC3

chr3:169896561

chr7:2834777

ENST00000495893

776_810

60.0

996.0

Zinc finger

FCS-type

Hgene

PHC3

chr3:169896561

chr7:2834777

ENST00000497658

776_810

60.0

152.0

Zinc finger

FCS-type

Tgene

GNA12

chr3:169896561

chr7:2834777

ENST00000275364

56_381

103.0

382.0

Domain

G-alpha

Tgene

GNA12

chr3:169896561

chr7:2834777

ENST00000275364

67_72

103.0

382.0

Nucleotide binding

GTP

Tgene

GNA12

chr3:169896561

chr7:2834777

ENST00000275364

59_72

103.0

382.0

Region

G1 motif

Top

Fusion Protein-Protein Interaction

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)

Gene

PPI interactors

Protein-protein interactors based on sequence similarity (STRING)

Gene	STRING network
PHC3
GNA12

- Retained interactions in fusion protein (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost interactions due to fusion (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs to PHC3-GNA12

Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Drug

Source

PMID

Top

Related Diseases to PHC3-GNA12

Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Disease

Source

PMID

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source