UTHEALTH HOME ABOUT SBMI A-Z WEBMAIL INSIDE THE UNIVERSITY

Home

Download

Statistics

Examples

Help

Contact

level1

	Fusion Gene Summary
	Fusion Gene Sample Information
	Fusion ORF Analysis
	Fusion Amino Acid Sequences
	Fusion Protein Functional Features
	Fusion Protein-Protein Interaction
	Related drugs with this fusion protein
	Related disease with this fusion protein

Fusion Protein:PHF21B-CLTCL1

Fusion Protein Summary

Fusion gene summary

Fusion partner gene information	Fusion gene name: PHF21B-CLTCL1
	FusionPDB ID: 64859
	FusionGDB2.0 ID: 64859
		Hgene	Tgene
	Gene symbol	PHF21B	CLTCL1
	Gene ID	112885	8218
	Gene name	PHD finger protein 21B	clathrin heavy chain like 1
	Synonyms	BHC80L\|PHF4	CHC22\|CLH22\|CLTCL\|CLTD
	Cytomap	22q13.31	22q11.21
	Type of gene	protein-coding	protein-coding
	Description	PHD finger protein 21BPHD finger protein 4	clathrin heavy chain 2CLH-22Clathrin, heavy polypeptide Dclathrin heavy chain on chromosome 22clathrin, heavy polypeptide-like 1
	Modification date	20200313	20200313
	UniProtAcc	.	P53675
Ensembl transtripts involved in fusion gene	ENST ids	ENST00000313237, ENST00000396103, ENST00000404079, ENST00000447824, ENST00000403565, ENST00000462631,	ENST00000442042, ENST00000263200, ENST00000353891, ENST00000427926,
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)	* DoF score	5 X 3 X 4=60	9 X 7 X 7=441
	# samples	5	12
	** MAII score	log2(5/60*10)=-0.263034405833794 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(12/441*10)=-1.877744249949 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)	PubMed: PHF21B [Title/Abstract] AND CLTCL1 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)	PHF21B(45404426)-CLTCL1(19230459), # samples:1
Anticipated loss of major functional domain due to fusion event.	PHF21B-CLTCL1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. PHF21B-CLTCL1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. PHF21B-CLTCL1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. PHF21B-CLTCL1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Tgene	CLTCL1	GO:0000278	mitotic cell cycle	19509056
Tgene	CLTCL1	GO:0000278	mitotic cell cycle	20065094
Tgene	CLTCL1	GO:0006898	receptor-mediated endocytosis	19509056

Fusion gene breakpoints across PHF21B (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across CLTCL1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Top

Fusion Gene Sample Information

Fusion gene information from FusionGDB2.0.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	KIRP	TCGA-P4-A5EB-01A	PHF21B	chr22	45404426	-	CLTCL1	chr22	19230459	-

Top

Fusion ORF Analysis

Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000313237	PHF21B	chr22	45404426	-	ENST00000353891	CLTCL1	chr22	19230459	-	5021	271	151	4503	1450
ENST00000313237	PHF21B	chr22	45404426	-	ENST00000263200	CLTCL1	chr22	19230459	-	5192	271	151	4674	1507
ENST00000313237	PHF21B	chr22	45404426	-	ENST00000427926	CLTCL1	chr22	19230459	-	5189	271	151	4674	1507
ENST00000396103	PHF21B	chr22	45404426	-	ENST00000353891	CLTCL1	chr22	19230459	-	4939	189	69	4421	1450
ENST00000396103	PHF21B	chr22	45404426	-	ENST00000263200	CLTCL1	chr22	19230459	-	5110	189	69	4592	1507
ENST00000396103	PHF21B	chr22	45404426	-	ENST00000427926	CLTCL1	chr22	19230459	-	5107	189	69	4592	1507
ENST00000404079	PHF21B	chr22	45404426	-	ENST00000353891	CLTCL1	chr22	19230459	-	5009	259	4	4491	1495
ENST00000404079	PHF21B	chr22	45404426	-	ENST00000263200	CLTCL1	chr22	19230459	-	5180	259	4	4662	1552
ENST00000404079	PHF21B	chr22	45404426	-	ENST00000427926	CLTCL1	chr22	19230459	-	5177	259	4	4662	1552
ENST00000447824	PHF21B	chr22	45404426	-	ENST00000353891	CLTCL1	chr22	19230459	-	4972	222	3	4454	1483
ENST00000447824	PHF21B	chr22	45404426	-	ENST00000263200	CLTCL1	chr22	19230459	-	5143	222	3	4625	1540
ENST00000447824	PHF21B	chr22	45404426	-	ENST00000427926	CLTCL1	chr22	19230459	-	5140	222	3	4625	1540

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000313237	ENST00000353891	PHF21B	chr22	45404426	-	CLTCL1	chr22	19230459	-	0.003363777	0.99663615
ENST00000313237	ENST00000263200	PHF21B	chr22	45404426	-	CLTCL1	chr22	19230459	-	0.003405531	0.9965945
ENST00000313237	ENST00000427926	PHF21B	chr22	45404426	-	CLTCL1	chr22	19230459	-	0.003421673	0.9965783
ENST00000396103	ENST00000353891	PHF21B	chr22	45404426	-	CLTCL1	chr22	19230459	-	0.003255846	0.99674416
ENST00000396103	ENST00000263200	PHF21B	chr22	45404426	-	CLTCL1	chr22	19230459	-	0.003316685	0.9966833
ENST00000396103	ENST00000427926	PHF21B	chr22	45404426	-	CLTCL1	chr22	19230459	-	0.003332685	0.9966673
ENST00000404079	ENST00000353891	PHF21B	chr22	45404426	-	CLTCL1	chr22	19230459	-	0.003596626	0.99640334
ENST00000404079	ENST00000263200	PHF21B	chr22	45404426	-	CLTCL1	chr22	19230459	-	0.003616537	0.9963834
ENST00000404079	ENST00000427926	PHF21B	chr22	45404426	-	CLTCL1	chr22	19230459	-	0.003629904	0.9963701
ENST00000447824	ENST00000353891	PHF21B	chr22	45404426	-	CLTCL1	chr22	19230459	-	0.003473695	0.9965263
ENST00000447824	ENST00000263200	PHF21B	chr22	45404426	-	CLTCL1	chr22	19230459	-	0.003498288	0.9965017
ENST00000447824	ENST00000427926	PHF21B	chr22	45404426	-	CLTCL1	chr22	19230459	-	0.003511313	0.9964887

Top

Fusion Amino Acid Sequences

For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>64859_64859_1_PHF21B-CLTCL1_PHF21B_chr22_45404426_ENST00000313237_CLTCL1_chr22_19230459_ENST00000263200_length(amino acids)=1507AA_BP=40
MELQSRPEALAVELARHQNGDLKKQLHERQPRIAALSDKQQNRVVGAMQLYSVDRKVSQPIEGHAAAFAEFKMEGNAKPATLFCFAVRNP
TGGKLHIIEVGQPAAGNQPFVKKAVDVFFPPEAQNDFPVAMQIGAKHGVIYLITKYGYLHLYDLESGVCICMNRISADTIFVTAPHKPTS
GIIGVNKKGQVLSVCVEEDNIVNYATNVLQNPDLGLRLAVRSNLAGAEKLFVRKFNTLFAQGSYAEAAKVAASAPKGILRTRETVQKFQS
IPAQSGQASPLLQYFGILLDQGQLNKLESLELCHLVLQQGRKQLLEKWLKEDKLECSEELGDLVKTTDPMLALSVYLRANVPSKVIQCFA
ETGQFQKIVLYAKKVGYTPDWIFLLRGVMKISPEQGLQFSRMLVQDEEPLANISQIVDIFMENSLIQQCTSFLLDALKNNRPAEGLLQTW
LLEMNLVHAPQVADAILGNKMFTHYDRAHIAQLCEKAGLLQQALEHYTDLYDIKRAVVHTHLLNPEWLVNFFGSLSVEDSVECLHAMLSA
NIRQNLQLCVQVASKYHEQLGTQALVELFESFKSYKGLFYFLGSIVNFSQDPDVHLKYIQAACKTGQIKEVERICRESSCYNPERVKNFL
KEAKLTDQLPLIIVCDRFGFVHDLVLYLYRNNLQRYIEIYVQKVNPSRTPAVIGGLLDVDCSEEVIKHLIMAVRGQFSTDELVAEVEKRN
RLKLLLPWLESQIQEGCEEPATHNALAKIYIDSNNSPECFLRENAYYDSSVVGRYCEKRDPHLACVAYERGQCDLELIKVCNENSLFKSE
ARYLVCRKDPELWAHVLEETNPSRRQLIDQVVQTALSETRDPEEISVTVKAFMTADLPNELIELLEKIVLDNSVFSEHRNLQNLLILTAI
KADRTRVMEYISRLDNYDALDIASIAVSSALYEEAFTVFHKFDMNASAIQVLIEHIGNLDRAYEFAERCNEPAVWSQLAQAQLQKDLVKE
AINSYIRGDDPSSYLEVVQSASRSNNWEDLVKFLQMARKKGRESYIETELIFALAKTSRVSELEDFINGPNNAHIQQVGDRCYEEGMYEA
AKLLYSNVSNFARLASTLVHLGEYQAAVDNSRKASSTRTWKEVCFACMDGQEFRFAQLCGLHIVIHADELEELMCYYQDRGYFEELILLL
EAALGLERAHMGMFTELAILYSKFKPQKMLEHLELFWSRVNIPKVLRAAEQAHLWAELVFLYDKYEEYDNAVLTMMSHPTEAWKEGQFKD
IITKVANVELCYRALQFYLDYKPLLINDLLLVLSPRLDHTWTVSFFSKAGQLPLVKPYLRSVQSHNNKSVNEALNHLLTEEEDYQGLRAS
IDAYDNFDNISLAQQLEKHQLMEFRCIAAYLYKGNNWWAQSVELCKKDHLYKDAMQHAAESRDAELAQKLLQWFLEEGKRECFAACLFTC

--------------------------------------------------------------

>64859_64859_2_PHF21B-CLTCL1_PHF21B_chr22_45404426_ENST00000313237_CLTCL1_chr22_19230459_ENST00000353891_length(amino acids)=1450AA_BP=40
MELQSRPEALAVELARHQNGDLKKQLHERQPRIAALSDKQQNRVVGAMQLYSVDRKVSQPIEGHAAAFAEFKMEGNAKPATLFCFAVRNP
TGGKLHIIEVGQPAAGNQPFVKKAVDVFFPPEAQNDFPVAMQIGAKHGVIYLITKYGYLHLYDLESGVCICMNRISADTIFVTAPHKPTS
GIIGVNKKGQVLSVCVEEDNIVNYATNVLQNPDLGLRLAVRSNLAGAEKLFVRKFNTLFAQGSYAEAAKVAASAPKGILRTRETVQKFQS
IPAQSGQASPLLQYFGILLDQGQLNKLESLELCHLVLQQGRKQLLEKWLKEDKLECSEELGDLVKTTDPMLALSVYLRANVPSKVIQCFA
ETGQFQKIVLYAKKVGYTPDWIFLLRGVMKISPEQGLQFSRMLVQDEEPLANISQIVDIFMENSLIQQCTSFLLDALKNNRPAEGLLQTW
LLEMNLVHAPQVADAILGNKMFTHYDRAHIAQLCEKAGLLQQALEHYTDLYDIKRAVVHTHLLNPEWLVNFFGSLSVEDSVECLHAMLSA
NIRQNLQLCVQVASKYHEQLGTQALVELFESFKSYKGLFYFLGSIVNFSQDPDVHLKYIQAACKTGQIKEVERICRESSCYNPERVKNFL
KEAKLTDQLPLIIVCDRFGFVHDLVLYLYRNNLQRYIEIYVQKVNPSRTPAVIGGLLDVDCSEEVIKHLIMAVRGQFSTDELVAEVEKRN
RLKLLLPWLESQIQEGCEEPATHNALAKIYIDSNNSPECFLRENAYYDSSVVGRYCEKRDPHLACVAYERGQCDLELIKVCNENSLFKSE
ARYLVCRKDPELWAHVLEETNPSRRQLIDQVVQTALSETRDPEEISVTVKAFMTADLPNELIELLEKIVLDNSVFSEHRNLQNLLILTAI
KADRTRVMEYISRLDNYDALDIASIAVSSALYEEAFTVFHKFDMNASAIQVLIEHIGNLDRAYEFAERCNEPAVWSQLAQAQLQKDLVKE
AINSYIRGDDPSSYLEVVQSASRSNNWEDLVKFLQMARKKGRESYIETELIFALAKTSRVSELEDFINGPNNAHIQQVGDRCYEEGMYEA
AKLLYSNVSNFARLASTLVHLGEYQAAVDNSRKASSTRTWKEVCFACMDGQEFRFAQLCGLHIVIHADELEELMCYYQDRGYFEELILLL
EAALGLERAHMGMFTELAILYSKFKPQKMLEHLELFWSRVNIPKVLRAAEQAHLWAELVFLYDKYEEYDNAVLTMMSHPTEAWKEGQFKD
IITKVANVELCYRALQFYLDYKPLLINDLLLVLSPRLDHTWTVSFFSKAGQLPLVKPYLRSVQSHNNKSVNEALNHLLTEEEDYQDAMQH
AAESRDAELAQKLLQWFLEEGKRECFAACLFTCYDLLRPDMVLELAWRHNLVDLAMPYFIQVMREYLSKVDKLDALESLRKQEEHVTEPA

--------------------------------------------------------------

>64859_64859_3_PHF21B-CLTCL1_PHF21B_chr22_45404426_ENST00000313237_CLTCL1_chr22_19230459_ENST00000427926_length(amino acids)=1507AA_BP=40
MELQSRPEALAVELARHQNGDLKKQLHERQPRIAALSDKQQNRVVGAMQLYSVDRKVSQPIEGHAAAFAEFKMEGNAKPATLFCFAVRNP
TGGKLHIIEVGQPAAGNQPFVKKAVDVFFPPEAQNDFPVAMQIGAKHGVIYLITKYGYLHLYDLESGVCICMNRISADTIFVTAPHKPTS
GIIGVNKKGQVLSVCVEEDNIVNYATNVLQNPDLGLRLAVRSNLAGAEKLFVRKFNTLFAQGSYAEAAKVAASAPKGILRTRETVQKFQS
IPAQSGQASPLLQYFGILLDQGQLNKLESLELCHLVLQQGRKQLLEKWLKEDKLECSEELGDLVKTTDPMLALSVYLRANVPSKVIQCFA
ETGQFQKIVLYAKKVGYTPDWIFLLRGVMKISPEQGLQFSRMLVQDEEPLANISQIVDIFMENSLIQQCTSFLLDALKNNRPAEGLLQTW
LLEMNLVHAPQVADAILGNKMFTHYDRAHIAQLCEKAGLLQQALEHYTDLYDIKRAVVHTHLLNPEWLVNFFGSLSVEDSVECLHAMLSA
NIRQNLQLCVQVASKYHEQLGTQALVELFESFKSYKGLFYFLGSIVNFSQDPDVHLKYIQAACKTGQIKEVERICRESSCYNPERVKNFL
KEAKLTDQLPLIIVCDRFGFVHDLVLYLYRNNLQRYIEIYVQKVNPSRTPAVIGGLLDVDCSEEVIKHLIMAVRGQFSTDELVAEVEKRN
RLKLLLPWLESQIQEGCEEPATHNALAKIYIDSNNSPECFLRENAYYDSSVVGRYCEKRDPHLACVAYERGQCDLELIKVCNENSLFKSE
ARYLVCRKDPELWAHVLEETNPSRRQLIDQVVQTALSETRDPEEISVTVKAFMTADLPNELIELLEKIVLDNSVFSEHRNLQNLLILTAI
KADRTRVMEYISRLDNYDALDIASIAVSSALYEEAFTVFHKFDMNASAIQVLIEHIGNLDRAYEFAERCNEPAVWSQLAQAQLQKDLVKE
AINSYIRGDDPSSYLEVVQSASRSNNWEDLVKFLQMARKKGRESYIETELIFALAKTSRVSELEDFINGPNNAHIQQVGDRCYEEGMYEA
AKLLYSNVSNFARLASTLVHLGEYQAAVDNSRKASSTRTWKEVCFACMDGQEFRFAQLCGLHIVIHADELEELMCYYQDRGYFEELILLL
EAALGLERAHMGMFTELAILYSKFKPQKMLEHLELFWSRVNIPKVLRAAEQAHLWAELVFLYDKYEEYDNAVLTMMSHPTEAWKEGQFKD
IITKVANVELCYRALQFYLDYKPLLINDLLLVLSPRLDHTWTVSFFSKAGQLPLVKPYLRSVQSHNNKSVNEALNHLLTEEEDYQGLRAS
IDAYDNFDNISLAQQLEKHQLMEFRCIAAYLYKGNNWWAQSVELCKKDHLYKDAMQHAAESRDAELAQKLLQWFLEEGKRECFAACLFTC

--------------------------------------------------------------

>64859_64859_4_PHF21B-CLTCL1_PHF21B_chr22_45404426_ENST00000396103_CLTCL1_chr22_19230459_ENST00000263200_length(amino acids)=1507AA_BP=40
MELQSRPEALAVELARHQNGDLKKQLHERQPRIAALSDKQQNRVVGAMQLYSVDRKVSQPIEGHAAAFAEFKMEGNAKPATLFCFAVRNP
TGGKLHIIEVGQPAAGNQPFVKKAVDVFFPPEAQNDFPVAMQIGAKHGVIYLITKYGYLHLYDLESGVCICMNRISADTIFVTAPHKPTS
GIIGVNKKGQVLSVCVEEDNIVNYATNVLQNPDLGLRLAVRSNLAGAEKLFVRKFNTLFAQGSYAEAAKVAASAPKGILRTRETVQKFQS
IPAQSGQASPLLQYFGILLDQGQLNKLESLELCHLVLQQGRKQLLEKWLKEDKLECSEELGDLVKTTDPMLALSVYLRANVPSKVIQCFA
ETGQFQKIVLYAKKVGYTPDWIFLLRGVMKISPEQGLQFSRMLVQDEEPLANISQIVDIFMENSLIQQCTSFLLDALKNNRPAEGLLQTW
LLEMNLVHAPQVADAILGNKMFTHYDRAHIAQLCEKAGLLQQALEHYTDLYDIKRAVVHTHLLNPEWLVNFFGSLSVEDSVECLHAMLSA
NIRQNLQLCVQVASKYHEQLGTQALVELFESFKSYKGLFYFLGSIVNFSQDPDVHLKYIQAACKTGQIKEVERICRESSCYNPERVKNFL
KEAKLTDQLPLIIVCDRFGFVHDLVLYLYRNNLQRYIEIYVQKVNPSRTPAVIGGLLDVDCSEEVIKHLIMAVRGQFSTDELVAEVEKRN
RLKLLLPWLESQIQEGCEEPATHNALAKIYIDSNNSPECFLRENAYYDSSVVGRYCEKRDPHLACVAYERGQCDLELIKVCNENSLFKSE
ARYLVCRKDPELWAHVLEETNPSRRQLIDQVVQTALSETRDPEEISVTVKAFMTADLPNELIELLEKIVLDNSVFSEHRNLQNLLILTAI
KADRTRVMEYISRLDNYDALDIASIAVSSALYEEAFTVFHKFDMNASAIQVLIEHIGNLDRAYEFAERCNEPAVWSQLAQAQLQKDLVKE
AINSYIRGDDPSSYLEVVQSASRSNNWEDLVKFLQMARKKGRESYIETELIFALAKTSRVSELEDFINGPNNAHIQQVGDRCYEEGMYEA
AKLLYSNVSNFARLASTLVHLGEYQAAVDNSRKASSTRTWKEVCFACMDGQEFRFAQLCGLHIVIHADELEELMCYYQDRGYFEELILLL
EAALGLERAHMGMFTELAILYSKFKPQKMLEHLELFWSRVNIPKVLRAAEQAHLWAELVFLYDKYEEYDNAVLTMMSHPTEAWKEGQFKD
IITKVANVELCYRALQFYLDYKPLLINDLLLVLSPRLDHTWTVSFFSKAGQLPLVKPYLRSVQSHNNKSVNEALNHLLTEEEDYQGLRAS
IDAYDNFDNISLAQQLEKHQLMEFRCIAAYLYKGNNWWAQSVELCKKDHLYKDAMQHAAESRDAELAQKLLQWFLEEGKRECFAACLFTC

--------------------------------------------------------------

>64859_64859_5_PHF21B-CLTCL1_PHF21B_chr22_45404426_ENST00000396103_CLTCL1_chr22_19230459_ENST00000353891_length(amino acids)=1450AA_BP=40
MELQSRPEALAVELARHQNGDLKKQLHERQPRIAALSDKQQNRVVGAMQLYSVDRKVSQPIEGHAAAFAEFKMEGNAKPATLFCFAVRNP
TGGKLHIIEVGQPAAGNQPFVKKAVDVFFPPEAQNDFPVAMQIGAKHGVIYLITKYGYLHLYDLESGVCICMNRISADTIFVTAPHKPTS
GIIGVNKKGQVLSVCVEEDNIVNYATNVLQNPDLGLRLAVRSNLAGAEKLFVRKFNTLFAQGSYAEAAKVAASAPKGILRTRETVQKFQS
IPAQSGQASPLLQYFGILLDQGQLNKLESLELCHLVLQQGRKQLLEKWLKEDKLECSEELGDLVKTTDPMLALSVYLRANVPSKVIQCFA
ETGQFQKIVLYAKKVGYTPDWIFLLRGVMKISPEQGLQFSRMLVQDEEPLANISQIVDIFMENSLIQQCTSFLLDALKNNRPAEGLLQTW
LLEMNLVHAPQVADAILGNKMFTHYDRAHIAQLCEKAGLLQQALEHYTDLYDIKRAVVHTHLLNPEWLVNFFGSLSVEDSVECLHAMLSA
NIRQNLQLCVQVASKYHEQLGTQALVELFESFKSYKGLFYFLGSIVNFSQDPDVHLKYIQAACKTGQIKEVERICRESSCYNPERVKNFL
KEAKLTDQLPLIIVCDRFGFVHDLVLYLYRNNLQRYIEIYVQKVNPSRTPAVIGGLLDVDCSEEVIKHLIMAVRGQFSTDELVAEVEKRN
RLKLLLPWLESQIQEGCEEPATHNALAKIYIDSNNSPECFLRENAYYDSSVVGRYCEKRDPHLACVAYERGQCDLELIKVCNENSLFKSE
ARYLVCRKDPELWAHVLEETNPSRRQLIDQVVQTALSETRDPEEISVTVKAFMTADLPNELIELLEKIVLDNSVFSEHRNLQNLLILTAI
KADRTRVMEYISRLDNYDALDIASIAVSSALYEEAFTVFHKFDMNASAIQVLIEHIGNLDRAYEFAERCNEPAVWSQLAQAQLQKDLVKE
AINSYIRGDDPSSYLEVVQSASRSNNWEDLVKFLQMARKKGRESYIETELIFALAKTSRVSELEDFINGPNNAHIQQVGDRCYEEGMYEA
AKLLYSNVSNFARLASTLVHLGEYQAAVDNSRKASSTRTWKEVCFACMDGQEFRFAQLCGLHIVIHADELEELMCYYQDRGYFEELILLL
EAALGLERAHMGMFTELAILYSKFKPQKMLEHLELFWSRVNIPKVLRAAEQAHLWAELVFLYDKYEEYDNAVLTMMSHPTEAWKEGQFKD
IITKVANVELCYRALQFYLDYKPLLINDLLLVLSPRLDHTWTVSFFSKAGQLPLVKPYLRSVQSHNNKSVNEALNHLLTEEEDYQDAMQH
AAESRDAELAQKLLQWFLEEGKRECFAACLFTCYDLLRPDMVLELAWRHNLVDLAMPYFIQVMREYLSKVDKLDALESLRKQEEHVTEPA

--------------------------------------------------------------

>64859_64859_6_PHF21B-CLTCL1_PHF21B_chr22_45404426_ENST00000396103_CLTCL1_chr22_19230459_ENST00000427926_length(amino acids)=1507AA_BP=40
MELQSRPEALAVELARHQNGDLKKQLHERQPRIAALSDKQQNRVVGAMQLYSVDRKVSQPIEGHAAAFAEFKMEGNAKPATLFCFAVRNP
TGGKLHIIEVGQPAAGNQPFVKKAVDVFFPPEAQNDFPVAMQIGAKHGVIYLITKYGYLHLYDLESGVCICMNRISADTIFVTAPHKPTS
GIIGVNKKGQVLSVCVEEDNIVNYATNVLQNPDLGLRLAVRSNLAGAEKLFVRKFNTLFAQGSYAEAAKVAASAPKGILRTRETVQKFQS
IPAQSGQASPLLQYFGILLDQGQLNKLESLELCHLVLQQGRKQLLEKWLKEDKLECSEELGDLVKTTDPMLALSVYLRANVPSKVIQCFA
ETGQFQKIVLYAKKVGYTPDWIFLLRGVMKISPEQGLQFSRMLVQDEEPLANISQIVDIFMENSLIQQCTSFLLDALKNNRPAEGLLQTW
LLEMNLVHAPQVADAILGNKMFTHYDRAHIAQLCEKAGLLQQALEHYTDLYDIKRAVVHTHLLNPEWLVNFFGSLSVEDSVECLHAMLSA
NIRQNLQLCVQVASKYHEQLGTQALVELFESFKSYKGLFYFLGSIVNFSQDPDVHLKYIQAACKTGQIKEVERICRESSCYNPERVKNFL
KEAKLTDQLPLIIVCDRFGFVHDLVLYLYRNNLQRYIEIYVQKVNPSRTPAVIGGLLDVDCSEEVIKHLIMAVRGQFSTDELVAEVEKRN
RLKLLLPWLESQIQEGCEEPATHNALAKIYIDSNNSPECFLRENAYYDSSVVGRYCEKRDPHLACVAYERGQCDLELIKVCNENSLFKSE
ARYLVCRKDPELWAHVLEETNPSRRQLIDQVVQTALSETRDPEEISVTVKAFMTADLPNELIELLEKIVLDNSVFSEHRNLQNLLILTAI
KADRTRVMEYISRLDNYDALDIASIAVSSALYEEAFTVFHKFDMNASAIQVLIEHIGNLDRAYEFAERCNEPAVWSQLAQAQLQKDLVKE
AINSYIRGDDPSSYLEVVQSASRSNNWEDLVKFLQMARKKGRESYIETELIFALAKTSRVSELEDFINGPNNAHIQQVGDRCYEEGMYEA
AKLLYSNVSNFARLASTLVHLGEYQAAVDNSRKASSTRTWKEVCFACMDGQEFRFAQLCGLHIVIHADELEELMCYYQDRGYFEELILLL
EAALGLERAHMGMFTELAILYSKFKPQKMLEHLELFWSRVNIPKVLRAAEQAHLWAELVFLYDKYEEYDNAVLTMMSHPTEAWKEGQFKD
IITKVANVELCYRALQFYLDYKPLLINDLLLVLSPRLDHTWTVSFFSKAGQLPLVKPYLRSVQSHNNKSVNEALNHLLTEEEDYQGLRAS
IDAYDNFDNISLAQQLEKHQLMEFRCIAAYLYKGNNWWAQSVELCKKDHLYKDAMQHAAESRDAELAQKLLQWFLEEGKRECFAACLFTC

--------------------------------------------------------------

>64859_64859_7_PHF21B-CLTCL1_PHF21B_chr22_45404426_ENST00000404079_CLTCL1_chr22_19230459_ENST00000263200_length(amino acids)=1552AA_BP=8
MLDTDSPCLLGSLFLPPPPAHTHTHTHSHTHPGLQTCTARGAPPGGLGPRPAPRAAPMRRQPQNGDLKKQLHERQPRIAALSDKQQNRVV
GAMQLYSVDRKVSQPIEGHAAAFAEFKMEGNAKPATLFCFAVRNPTGGKLHIIEVGQPAAGNQPFVKKAVDVFFPPEAQNDFPVAMQIGA
KHGVIYLITKYGYLHLYDLESGVCICMNRISADTIFVTAPHKPTSGIIGVNKKGQVLSVCVEEDNIVNYATNVLQNPDLGLRLAVRSNLA
GAEKLFVRKFNTLFAQGSYAEAAKVAASAPKGILRTRETVQKFQSIPAQSGQASPLLQYFGILLDQGQLNKLESLELCHLVLQQGRKQLL
EKWLKEDKLECSEELGDLVKTTDPMLALSVYLRANVPSKVIQCFAETGQFQKIVLYAKKVGYTPDWIFLLRGVMKISPEQGLQFSRMLVQ
DEEPLANISQIVDIFMENSLIQQCTSFLLDALKNNRPAEGLLQTWLLEMNLVHAPQVADAILGNKMFTHYDRAHIAQLCEKAGLLQQALE
HYTDLYDIKRAVVHTHLLNPEWLVNFFGSLSVEDSVECLHAMLSANIRQNLQLCVQVASKYHEQLGTQALVELFESFKSYKGLFYFLGSI
VNFSQDPDVHLKYIQAACKTGQIKEVERICRESSCYNPERVKNFLKEAKLTDQLPLIIVCDRFGFVHDLVLYLYRNNLQRYIEIYVQKVN
PSRTPAVIGGLLDVDCSEEVIKHLIMAVRGQFSTDELVAEVEKRNRLKLLLPWLESQIQEGCEEPATHNALAKIYIDSNNSPECFLRENA
YYDSSVVGRYCEKRDPHLACVAYERGQCDLELIKVCNENSLFKSEARYLVCRKDPELWAHVLEETNPSRRQLIDQVVQTALSETRDPEEI
SVTVKAFMTADLPNELIELLEKIVLDNSVFSEHRNLQNLLILTAIKADRTRVMEYISRLDNYDALDIASIAVSSALYEEAFTVFHKFDMN
ASAIQVLIEHIGNLDRAYEFAERCNEPAVWSQLAQAQLQKDLVKEAINSYIRGDDPSSYLEVVQSASRSNNWEDLVKFLQMARKKGRESY
IETELIFALAKTSRVSELEDFINGPNNAHIQQVGDRCYEEGMYEAAKLLYSNVSNFARLASTLVHLGEYQAAVDNSRKASSTRTWKEVCF
ACMDGQEFRFAQLCGLHIVIHADELEELMCYYQDRGYFEELILLLEAALGLERAHMGMFTELAILYSKFKPQKMLEHLELFWSRVNIPKV
LRAAEQAHLWAELVFLYDKYEEYDNAVLTMMSHPTEAWKEGQFKDIITKVANVELCYRALQFYLDYKPLLINDLLLVLSPRLDHTWTVSF
FSKAGQLPLVKPYLRSVQSHNNKSVNEALNHLLTEEEDYQGLRASIDAYDNFDNISLAQQLEKHQLMEFRCIAAYLYKGNNWWAQSVELC
KKDHLYKDAMQHAAESRDAELAQKLLQWFLEEGKRECFAACLFTCYDLLRPDMVLELAWRHNLVDLAMPYFIQVMREYLSKVDKLDALES

--------------------------------------------------------------

>64859_64859_8_PHF21B-CLTCL1_PHF21B_chr22_45404426_ENST00000404079_CLTCL1_chr22_19230459_ENST00000353891_length(amino acids)=1495AA_BP=8
MLDTDSPCLLGSLFLPPPPAHTHTHTHSHTHPGLQTCTARGAPPGGLGPRPAPRAAPMRRQPQNGDLKKQLHERQPRIAALSDKQQNRVV
GAMQLYSVDRKVSQPIEGHAAAFAEFKMEGNAKPATLFCFAVRNPTGGKLHIIEVGQPAAGNQPFVKKAVDVFFPPEAQNDFPVAMQIGA
KHGVIYLITKYGYLHLYDLESGVCICMNRISADTIFVTAPHKPTSGIIGVNKKGQVLSVCVEEDNIVNYATNVLQNPDLGLRLAVRSNLA
GAEKLFVRKFNTLFAQGSYAEAAKVAASAPKGILRTRETVQKFQSIPAQSGQASPLLQYFGILLDQGQLNKLESLELCHLVLQQGRKQLL
EKWLKEDKLECSEELGDLVKTTDPMLALSVYLRANVPSKVIQCFAETGQFQKIVLYAKKVGYTPDWIFLLRGVMKISPEQGLQFSRMLVQ
DEEPLANISQIVDIFMENSLIQQCTSFLLDALKNNRPAEGLLQTWLLEMNLVHAPQVADAILGNKMFTHYDRAHIAQLCEKAGLLQQALE
HYTDLYDIKRAVVHTHLLNPEWLVNFFGSLSVEDSVECLHAMLSANIRQNLQLCVQVASKYHEQLGTQALVELFESFKSYKGLFYFLGSI
VNFSQDPDVHLKYIQAACKTGQIKEVERICRESSCYNPERVKNFLKEAKLTDQLPLIIVCDRFGFVHDLVLYLYRNNLQRYIEIYVQKVN
PSRTPAVIGGLLDVDCSEEVIKHLIMAVRGQFSTDELVAEVEKRNRLKLLLPWLESQIQEGCEEPATHNALAKIYIDSNNSPECFLRENA
YYDSSVVGRYCEKRDPHLACVAYERGQCDLELIKVCNENSLFKSEARYLVCRKDPELWAHVLEETNPSRRQLIDQVVQTALSETRDPEEI
SVTVKAFMTADLPNELIELLEKIVLDNSVFSEHRNLQNLLILTAIKADRTRVMEYISRLDNYDALDIASIAVSSALYEEAFTVFHKFDMN
ASAIQVLIEHIGNLDRAYEFAERCNEPAVWSQLAQAQLQKDLVKEAINSYIRGDDPSSYLEVVQSASRSNNWEDLVKFLQMARKKGRESY
IETELIFALAKTSRVSELEDFINGPNNAHIQQVGDRCYEEGMYEAAKLLYSNVSNFARLASTLVHLGEYQAAVDNSRKASSTRTWKEVCF
ACMDGQEFRFAQLCGLHIVIHADELEELMCYYQDRGYFEELILLLEAALGLERAHMGMFTELAILYSKFKPQKMLEHLELFWSRVNIPKV
LRAAEQAHLWAELVFLYDKYEEYDNAVLTMMSHPTEAWKEGQFKDIITKVANVELCYRALQFYLDYKPLLINDLLLVLSPRLDHTWTVSF
FSKAGQLPLVKPYLRSVQSHNNKSVNEALNHLLTEEEDYQDAMQHAAESRDAELAQKLLQWFLEEGKRECFAACLFTCYDLLRPDMVLEL

--------------------------------------------------------------

>64859_64859_9_PHF21B-CLTCL1_PHF21B_chr22_45404426_ENST00000404079_CLTCL1_chr22_19230459_ENST00000427926_length(amino acids)=1552AA_BP=8
MLDTDSPCLLGSLFLPPPPAHTHTHTHSHTHPGLQTCTARGAPPGGLGPRPAPRAAPMRRQPQNGDLKKQLHERQPRIAALSDKQQNRVV
GAMQLYSVDRKVSQPIEGHAAAFAEFKMEGNAKPATLFCFAVRNPTGGKLHIIEVGQPAAGNQPFVKKAVDVFFPPEAQNDFPVAMQIGA
KHGVIYLITKYGYLHLYDLESGVCICMNRISADTIFVTAPHKPTSGIIGVNKKGQVLSVCVEEDNIVNYATNVLQNPDLGLRLAVRSNLA
GAEKLFVRKFNTLFAQGSYAEAAKVAASAPKGILRTRETVQKFQSIPAQSGQASPLLQYFGILLDQGQLNKLESLELCHLVLQQGRKQLL
EKWLKEDKLECSEELGDLVKTTDPMLALSVYLRANVPSKVIQCFAETGQFQKIVLYAKKVGYTPDWIFLLRGVMKISPEQGLQFSRMLVQ
DEEPLANISQIVDIFMENSLIQQCTSFLLDALKNNRPAEGLLQTWLLEMNLVHAPQVADAILGNKMFTHYDRAHIAQLCEKAGLLQQALE
HYTDLYDIKRAVVHTHLLNPEWLVNFFGSLSVEDSVECLHAMLSANIRQNLQLCVQVASKYHEQLGTQALVELFESFKSYKGLFYFLGSI
VNFSQDPDVHLKYIQAACKTGQIKEVERICRESSCYNPERVKNFLKEAKLTDQLPLIIVCDRFGFVHDLVLYLYRNNLQRYIEIYVQKVN
PSRTPAVIGGLLDVDCSEEVIKHLIMAVRGQFSTDELVAEVEKRNRLKLLLPWLESQIQEGCEEPATHNALAKIYIDSNNSPECFLRENA
YYDSSVVGRYCEKRDPHLACVAYERGQCDLELIKVCNENSLFKSEARYLVCRKDPELWAHVLEETNPSRRQLIDQVVQTALSETRDPEEI
SVTVKAFMTADLPNELIELLEKIVLDNSVFSEHRNLQNLLILTAIKADRTRVMEYISRLDNYDALDIASIAVSSALYEEAFTVFHKFDMN
ASAIQVLIEHIGNLDRAYEFAERCNEPAVWSQLAQAQLQKDLVKEAINSYIRGDDPSSYLEVVQSASRSNNWEDLVKFLQMARKKGRESY
IETELIFALAKTSRVSELEDFINGPNNAHIQQVGDRCYEEGMYEAAKLLYSNVSNFARLASTLVHLGEYQAAVDNSRKASSTRTWKEVCF
ACMDGQEFRFAQLCGLHIVIHADELEELMCYYQDRGYFEELILLLEAALGLERAHMGMFTELAILYSKFKPQKMLEHLELFWSRVNIPKV
LRAAEQAHLWAELVFLYDKYEEYDNAVLTMMSHPTEAWKEGQFKDIITKVANVELCYRALQFYLDYKPLLINDLLLVLSPRLDHTWTVSF
FSKAGQLPLVKPYLRSVQSHNNKSVNEALNHLLTEEEDYQGLRASIDAYDNFDNISLAQQLEKHQLMEFRCIAAYLYKGNNWWAQSVELC
KKDHLYKDAMQHAAESRDAELAQKLLQWFLEEGKRECFAACLFTCYDLLRPDMVLELAWRHNLVDLAMPYFIQVMREYLSKVDKLDALES

--------------------------------------------------------------

>64859_64859_10_PHF21B-CLTCL1_PHF21B_chr22_45404426_ENST00000447824_CLTCL1_chr22_19230459_ENST00000263200_length(amino acids)=1540AA_BP=7
MFLPPPPAHTHTHTHSHTHPGLQTCTARGAPPGGLGPRPAPRAAPMRRQPQNGDLKKQLHERQPRIAALSDKQQNRVVGAMQLYSVDRKV
SQPIEGHAAAFAEFKMEGNAKPATLFCFAVRNPTGGKLHIIEVGQPAAGNQPFVKKAVDVFFPPEAQNDFPVAMQIGAKHGVIYLITKYG
YLHLYDLESGVCICMNRISADTIFVTAPHKPTSGIIGVNKKGQVLSVCVEEDNIVNYATNVLQNPDLGLRLAVRSNLAGAEKLFVRKFNT
LFAQGSYAEAAKVAASAPKGILRTRETVQKFQSIPAQSGQASPLLQYFGILLDQGQLNKLESLELCHLVLQQGRKQLLEKWLKEDKLECS
EELGDLVKTTDPMLALSVYLRANVPSKVIQCFAETGQFQKIVLYAKKVGYTPDWIFLLRGVMKISPEQGLQFSRMLVQDEEPLANISQIV
DIFMENSLIQQCTSFLLDALKNNRPAEGLLQTWLLEMNLVHAPQVADAILGNKMFTHYDRAHIAQLCEKAGLLQQALEHYTDLYDIKRAV
VHTHLLNPEWLVNFFGSLSVEDSVECLHAMLSANIRQNLQLCVQVASKYHEQLGTQALVELFESFKSYKGLFYFLGSIVNFSQDPDVHLK
YIQAACKTGQIKEVERICRESSCYNPERVKNFLKEAKLTDQLPLIIVCDRFGFVHDLVLYLYRNNLQRYIEIYVQKVNPSRTPAVIGGLL
DVDCSEEVIKHLIMAVRGQFSTDELVAEVEKRNRLKLLLPWLESQIQEGCEEPATHNALAKIYIDSNNSPECFLRENAYYDSSVVGRYCE
KRDPHLACVAYERGQCDLELIKVCNENSLFKSEARYLVCRKDPELWAHVLEETNPSRRQLIDQVVQTALSETRDPEEISVTVKAFMTADL
PNELIELLEKIVLDNSVFSEHRNLQNLLILTAIKADRTRVMEYISRLDNYDALDIASIAVSSALYEEAFTVFHKFDMNASAIQVLIEHIG
NLDRAYEFAERCNEPAVWSQLAQAQLQKDLVKEAINSYIRGDDPSSYLEVVQSASRSNNWEDLVKFLQMARKKGRESYIETELIFALAKT
SRVSELEDFINGPNNAHIQQVGDRCYEEGMYEAAKLLYSNVSNFARLASTLVHLGEYQAAVDNSRKASSTRTWKEVCFACMDGQEFRFAQ
LCGLHIVIHADELEELMCYYQDRGYFEELILLLEAALGLERAHMGMFTELAILYSKFKPQKMLEHLELFWSRVNIPKVLRAAEQAHLWAE
LVFLYDKYEEYDNAVLTMMSHPTEAWKEGQFKDIITKVANVELCYRALQFYLDYKPLLINDLLLVLSPRLDHTWTVSFFSKAGQLPLVKP
YLRSVQSHNNKSVNEALNHLLTEEEDYQGLRASIDAYDNFDNISLAQQLEKHQLMEFRCIAAYLYKGNNWWAQSVELCKKDHLYKDAMQH
AAESRDAELAQKLLQWFLEEGKRECFAACLFTCYDLLRPDMVLELAWRHNLVDLAMPYFIQVMREYLSKVDKLDALESLRKQEEHVTEPA

--------------------------------------------------------------

>64859_64859_11_PHF21B-CLTCL1_PHF21B_chr22_45404426_ENST00000447824_CLTCL1_chr22_19230459_ENST00000353891_length(amino acids)=1483AA_BP=7
MFLPPPPAHTHTHTHSHTHPGLQTCTARGAPPGGLGPRPAPRAAPMRRQPQNGDLKKQLHERQPRIAALSDKQQNRVVGAMQLYSVDRKV
SQPIEGHAAAFAEFKMEGNAKPATLFCFAVRNPTGGKLHIIEVGQPAAGNQPFVKKAVDVFFPPEAQNDFPVAMQIGAKHGVIYLITKYG
YLHLYDLESGVCICMNRISADTIFVTAPHKPTSGIIGVNKKGQVLSVCVEEDNIVNYATNVLQNPDLGLRLAVRSNLAGAEKLFVRKFNT
LFAQGSYAEAAKVAASAPKGILRTRETVQKFQSIPAQSGQASPLLQYFGILLDQGQLNKLESLELCHLVLQQGRKQLLEKWLKEDKLECS
EELGDLVKTTDPMLALSVYLRANVPSKVIQCFAETGQFQKIVLYAKKVGYTPDWIFLLRGVMKISPEQGLQFSRMLVQDEEPLANISQIV
DIFMENSLIQQCTSFLLDALKNNRPAEGLLQTWLLEMNLVHAPQVADAILGNKMFTHYDRAHIAQLCEKAGLLQQALEHYTDLYDIKRAV
VHTHLLNPEWLVNFFGSLSVEDSVECLHAMLSANIRQNLQLCVQVASKYHEQLGTQALVELFESFKSYKGLFYFLGSIVNFSQDPDVHLK
YIQAACKTGQIKEVERICRESSCYNPERVKNFLKEAKLTDQLPLIIVCDRFGFVHDLVLYLYRNNLQRYIEIYVQKVNPSRTPAVIGGLL
DVDCSEEVIKHLIMAVRGQFSTDELVAEVEKRNRLKLLLPWLESQIQEGCEEPATHNALAKIYIDSNNSPECFLRENAYYDSSVVGRYCE
KRDPHLACVAYERGQCDLELIKVCNENSLFKSEARYLVCRKDPELWAHVLEETNPSRRQLIDQVVQTALSETRDPEEISVTVKAFMTADL
PNELIELLEKIVLDNSVFSEHRNLQNLLILTAIKADRTRVMEYISRLDNYDALDIASIAVSSALYEEAFTVFHKFDMNASAIQVLIEHIG
NLDRAYEFAERCNEPAVWSQLAQAQLQKDLVKEAINSYIRGDDPSSYLEVVQSASRSNNWEDLVKFLQMARKKGRESYIETELIFALAKT
SRVSELEDFINGPNNAHIQQVGDRCYEEGMYEAAKLLYSNVSNFARLASTLVHLGEYQAAVDNSRKASSTRTWKEVCFACMDGQEFRFAQ
LCGLHIVIHADELEELMCYYQDRGYFEELILLLEAALGLERAHMGMFTELAILYSKFKPQKMLEHLELFWSRVNIPKVLRAAEQAHLWAE
LVFLYDKYEEYDNAVLTMMSHPTEAWKEGQFKDIITKVANVELCYRALQFYLDYKPLLINDLLLVLSPRLDHTWTVSFFSKAGQLPLVKP
YLRSVQSHNNKSVNEALNHLLTEEEDYQDAMQHAAESRDAELAQKLLQWFLEEGKRECFAACLFTCYDLLRPDMVLELAWRHNLVDLAMP

--------------------------------------------------------------

>64859_64859_12_PHF21B-CLTCL1_PHF21B_chr22_45404426_ENST00000447824_CLTCL1_chr22_19230459_ENST00000427926_length(amino acids)=1540AA_BP=7
MFLPPPPAHTHTHTHSHTHPGLQTCTARGAPPGGLGPRPAPRAAPMRRQPQNGDLKKQLHERQPRIAALSDKQQNRVVGAMQLYSVDRKV
SQPIEGHAAAFAEFKMEGNAKPATLFCFAVRNPTGGKLHIIEVGQPAAGNQPFVKKAVDVFFPPEAQNDFPVAMQIGAKHGVIYLITKYG
YLHLYDLESGVCICMNRISADTIFVTAPHKPTSGIIGVNKKGQVLSVCVEEDNIVNYATNVLQNPDLGLRLAVRSNLAGAEKLFVRKFNT
LFAQGSYAEAAKVAASAPKGILRTRETVQKFQSIPAQSGQASPLLQYFGILLDQGQLNKLESLELCHLVLQQGRKQLLEKWLKEDKLECS
EELGDLVKTTDPMLALSVYLRANVPSKVIQCFAETGQFQKIVLYAKKVGYTPDWIFLLRGVMKISPEQGLQFSRMLVQDEEPLANISQIV
DIFMENSLIQQCTSFLLDALKNNRPAEGLLQTWLLEMNLVHAPQVADAILGNKMFTHYDRAHIAQLCEKAGLLQQALEHYTDLYDIKRAV
VHTHLLNPEWLVNFFGSLSVEDSVECLHAMLSANIRQNLQLCVQVASKYHEQLGTQALVELFESFKSYKGLFYFLGSIVNFSQDPDVHLK
YIQAACKTGQIKEVERICRESSCYNPERVKNFLKEAKLTDQLPLIIVCDRFGFVHDLVLYLYRNNLQRYIEIYVQKVNPSRTPAVIGGLL
DVDCSEEVIKHLIMAVRGQFSTDELVAEVEKRNRLKLLLPWLESQIQEGCEEPATHNALAKIYIDSNNSPECFLRENAYYDSSVVGRYCE
KRDPHLACVAYERGQCDLELIKVCNENSLFKSEARYLVCRKDPELWAHVLEETNPSRRQLIDQVVQTALSETRDPEEISVTVKAFMTADL
PNELIELLEKIVLDNSVFSEHRNLQNLLILTAIKADRTRVMEYISRLDNYDALDIASIAVSSALYEEAFTVFHKFDMNASAIQVLIEHIG
NLDRAYEFAERCNEPAVWSQLAQAQLQKDLVKEAINSYIRGDDPSSYLEVVQSASRSNNWEDLVKFLQMARKKGRESYIETELIFALAKT
SRVSELEDFINGPNNAHIQQVGDRCYEEGMYEAAKLLYSNVSNFARLASTLVHLGEYQAAVDNSRKASSTRTWKEVCFACMDGQEFRFAQ
LCGLHIVIHADELEELMCYYQDRGYFEELILLLEAALGLERAHMGMFTELAILYSKFKPQKMLEHLELFWSRVNIPKVLRAAEQAHLWAE
LVFLYDKYEEYDNAVLTMMSHPTEAWKEGQFKDIITKVANVELCYRALQFYLDYKPLLINDLLLVLSPRLDHTWTVSFFSKAGQLPLVKP
YLRSVQSHNNKSVNEALNHLLTEEEDYQGLRASIDAYDNFDNISLAQQLEKHQLMEFRCIAAYLYKGNNWWAQSVELCKKDHLYKDAMQH
AAESRDAELAQKLLQWFLEEGKRECFAACLFTCYDLLRPDMVLELAWRHNLVDLAMPYFIQVMREYLSKVDKLDALESLRKQEEHVTEPA

--------------------------------------------------------------

Top

Fusion Protein Functional Features

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr22:45404426/chr22:19230459)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	CLTCL1 P53675
FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.	FUNCTION: Clathrin is the major protein of the polyhedral coat of coated pits and vesicles. Two different adapter protein complexes link the clathrin lattice either to the plasma membrane or to the trans-Golgi network (By similarity). {ECO:0000250}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
* Minus value of BPloci means that the break pointn is located before the CDS.

- Retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

CLTCL1

chr22:45404426

chr22:19230459

ENST00000263200

1213_1522

173.0

1712.3333333333333

Region

Involved in binding clathrin light chain

Tgene

CLTCL1

chr22:45404426

chr22:19230459

ENST00000263200

1551_1640

173.0

1712.3333333333333

Region

Trimerization

Tgene

CLTCL1

chr22:45404426

chr22:19230459

ENST00000263200

196_257

173.0

1712.3333333333333

Region

Note=WD40-like repeat 5

Tgene

CLTCL1

chr22:45404426

chr22:19230459

ENST00000263200

258_301

173.0

1712.3333333333333

Region

Note=WD40-like repeat 6

Tgene

CLTCL1

chr22:45404426

chr22:19230459

ENST00000263200

302_330

173.0

1712.3333333333333

Region

Note=WD40-like repeat 7

Tgene

CLTCL1

chr22:45404426

chr22:19230459

ENST00000263200

449_465

173.0

1712.3333333333333

Region

Binding site for the uncoating ATPase%2C involved in lattice disassembly

Tgene

CLTCL1

chr22:45404426

chr22:19230459

ENST00000263200

480_523

173.0

1712.3333333333333

Region

Note=Flexible linker

Tgene

CLTCL1

chr22:45404426

chr22:19230459

ENST00000263200

524_1640

173.0

1712.3333333333333

Region

Note=Heavy chain arm

Tgene

CLTCL1

chr22:45404426

chr22:19230459

ENST00000263200

524_634

173.0

1712.3333333333333

Region

Note=Distal segment

Tgene

CLTCL1

chr22:45404426

chr22:19230459

ENST00000263200

639_1640

173.0

1712.3333333333333

Region

Note=Proximal segment

Tgene

CLTCL1

chr22:45404426

chr22:19230459

ENST00000353891

1213_1522

173.0

1665.0

Region

Involved in binding clathrin light chain

Tgene

CLTCL1

chr22:45404426

chr22:19230459

ENST00000353891

1551_1640

173.0

1665.0

Region

Trimerization

Tgene

CLTCL1

chr22:45404426

chr22:19230459

ENST00000353891

196_257

173.0

1665.0

Region

Note=WD40-like repeat 5

Tgene

CLTCL1

chr22:45404426

chr22:19230459

ENST00000353891

258_301

173.0

1665.0

Region

Note=WD40-like repeat 6

Tgene

CLTCL1

chr22:45404426

chr22:19230459

ENST00000353891

302_330

173.0

1665.0

Region

Note=WD40-like repeat 7

Tgene

CLTCL1

chr22:45404426

chr22:19230459

ENST00000353891

449_465

173.0

1665.0

Region

Binding site for the uncoating ATPase%2C involved in lattice disassembly

Tgene

CLTCL1

chr22:45404426

chr22:19230459

ENST00000353891

480_523

173.0

1665.0

Region

Note=Flexible linker

Tgene

CLTCL1

chr22:45404426

chr22:19230459

ENST00000353891

524_1640

173.0

1665.0

Region

Note=Heavy chain arm

Tgene

CLTCL1

chr22:45404426

chr22:19230459

ENST00000353891

524_634

173.0

1665.0

Region

Note=Distal segment

Tgene

CLTCL1

chr22:45404426

chr22:19230459

ENST00000353891

639_1640

173.0

1665.0

Region

Note=Proximal segment

Tgene

CLTCL1

chr22:45404426

chr22:19230459

ENST00000427926

1213_1522

173.0

1710.6666666666667

Region

Involved in binding clathrin light chain

Tgene

CLTCL1

chr22:45404426

chr22:19230459

ENST00000427926

1551_1640

173.0

1710.6666666666667

Region

Trimerization

Tgene

CLTCL1

chr22:45404426

chr22:19230459

ENST00000427926

196_257

173.0

1710.6666666666667

Region

Note=WD40-like repeat 5

Tgene

CLTCL1

chr22:45404426

chr22:19230459

ENST00000427926

258_301

173.0

1710.6666666666667

Region

Note=WD40-like repeat 6

Tgene

CLTCL1

chr22:45404426

chr22:19230459

ENST00000427926

302_330

173.0

1710.6666666666667

Region

Note=WD40-like repeat 7

Tgene

CLTCL1

chr22:45404426

chr22:19230459

ENST00000427926

449_465

173.0

1710.6666666666667

Region

Binding site for the uncoating ATPase%2C involved in lattice disassembly

Tgene

CLTCL1

chr22:45404426

chr22:19230459

ENST00000427926

480_523

173.0

1710.6666666666667

Region

Note=Flexible linker

Tgene

CLTCL1

chr22:45404426

chr22:19230459

ENST00000427926

524_1640

173.0

1710.6666666666667

Region

Note=Heavy chain arm

Tgene

CLTCL1

chr22:45404426

chr22:19230459

ENST00000427926

524_634

173.0

1710.6666666666667

Region

Note=Distal segment

Tgene

CLTCL1

chr22:45404426

chr22:19230459

ENST00000427926

639_1640

173.0

1710.6666666666667

Region

Note=Proximal segment

Tgene

CLTCL1

chr22:45404426

chr22:19230459

ENST00000263200

1128_1269

173.0

1712.3333333333333

Repeat

Note=CHCR 5

Tgene

CLTCL1

chr22:45404426

chr22:19230459

ENST00000263200

1274_1420

173.0

1712.3333333333333

Repeat

Note=CHCR 6

Tgene

CLTCL1

chr22:45404426

chr22:19230459

ENST00000263200

1423_1566

173.0

1712.3333333333333

Repeat

Note=CHCR 7

Tgene

CLTCL1

chr22:45404426

chr22:19230459

ENST00000263200

537_683

173.0

1712.3333333333333

Repeat

Note=CHCR 1

Tgene

CLTCL1

chr22:45404426

chr22:19230459

ENST00000263200

686_828

173.0

1712.3333333333333

Repeat

Note=CHCR 2

Tgene

CLTCL1

chr22:45404426

chr22:19230459

ENST00000263200

833_972

173.0

1712.3333333333333

Repeat

Note=CHCR 3

Tgene

CLTCL1

chr22:45404426

chr22:19230459

ENST00000263200

979_1124

173.0

1712.3333333333333

Repeat

Note=CHCR 4

Tgene

CLTCL1

chr22:45404426

chr22:19230459

ENST00000353891

1128_1269

173.0

1665.0

Repeat

Note=CHCR 5

Tgene

CLTCL1

chr22:45404426

chr22:19230459

ENST00000353891

1274_1420

173.0

1665.0

Repeat

Note=CHCR 6

Tgene

CLTCL1

chr22:45404426

chr22:19230459

ENST00000353891

1423_1566

173.0

1665.0

Repeat

Note=CHCR 7

Tgene

CLTCL1

chr22:45404426

chr22:19230459

ENST00000353891

537_683

173.0

1665.0

Repeat

Note=CHCR 1

Tgene

CLTCL1

chr22:45404426

chr22:19230459

ENST00000353891

686_828

173.0

1665.0

Repeat

Note=CHCR 2

Tgene

CLTCL1

chr22:45404426

chr22:19230459

ENST00000353891

833_972

173.0

1665.0

Repeat

Note=CHCR 3

Tgene

CLTCL1

chr22:45404426

chr22:19230459

ENST00000353891

979_1124

173.0

1665.0

Repeat

Note=CHCR 4

Tgene

CLTCL1

chr22:45404426

chr22:19230459

ENST00000427926

1128_1269

173.0

1710.6666666666667

Repeat

Note=CHCR 5

Tgene

CLTCL1

chr22:45404426

chr22:19230459

ENST00000427926

1274_1420

173.0

1710.6666666666667

Repeat

Note=CHCR 6

Tgene

CLTCL1

chr22:45404426

chr22:19230459

ENST00000427926

1423_1566

173.0

1710.6666666666667

Repeat

Note=CHCR 7

Tgene

CLTCL1

chr22:45404426

chr22:19230459

ENST00000427926

537_683

173.0

1710.6666666666667

Repeat

Note=CHCR 1

Tgene

CLTCL1

chr22:45404426

chr22:19230459

ENST00000427926

686_828

173.0

1710.6666666666667

Repeat

Note=CHCR 2

Tgene

CLTCL1

chr22:45404426

chr22:19230459

ENST00000427926

833_972

173.0

1710.6666666666667

Repeat

Note=CHCR 3

Tgene

CLTCL1

chr22:45404426

chr22:19230459

ENST00000427926

979_1124

173.0

1710.6666666666667

Repeat

Note=CHCR 4

- Not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

PHF21B

chr22:45404426

chr22:19230459

ENST00000313237

423_465

40.0

532.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

PHF21B

chr22:45404426

chr22:19230459

ENST00000396103

423_465

40.0

490.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

PHF21B

chr22:45404426

chr22:19230459

ENST00000404079

423_465

28.0

478.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

PHF21B

chr22:45404426

chr22:19230459

ENST00000313237

352_399

40.0

532.0

Zinc finger

PHD-type

Hgene

PHF21B

chr22:45404426

chr22:19230459

ENST00000396103

352_399

40.0

490.0

Zinc finger

PHD-type

Hgene

PHF21B

chr22:45404426

chr22:19230459

ENST00000404079

352_399

28.0

478.0

Zinc finger

PHD-type

Tgene

CLTCL1

chr22:45404426

chr22:19230459

ENST00000263200

108_149

173.0

1712.3333333333333

Region

Note=WD40-like repeat 3

Tgene

CLTCL1

chr22:45404426

chr22:19230459

ENST00000263200

150_195

173.0

1712.3333333333333

Region

Note=WD40-like repeat 4

Tgene

CLTCL1

chr22:45404426

chr22:19230459

ENST00000263200

24_67

173.0

1712.3333333333333

Region

Note=WD40-like repeat 1

Tgene

CLTCL1

chr22:45404426

chr22:19230459

ENST00000263200

2_479

173.0

1712.3333333333333

Region

Note=Globular terminal domain

Tgene

CLTCL1

chr22:45404426

chr22:19230459

ENST00000263200

68_107

173.0

1712.3333333333333

Region

Note=WD40-like repeat 2

Tgene

CLTCL1

chr22:45404426

chr22:19230459

ENST00000353891

108_149

173.0

1665.0

Region

Note=WD40-like repeat 3

Tgene

CLTCL1

chr22:45404426

chr22:19230459

ENST00000353891

150_195

173.0

1665.0

Region

Note=WD40-like repeat 4

Tgene

CLTCL1

chr22:45404426

chr22:19230459

ENST00000353891

24_67

173.0

1665.0

Region

Note=WD40-like repeat 1

Tgene

CLTCL1

chr22:45404426

chr22:19230459

ENST00000353891

2_479

173.0

1665.0

Region

Note=Globular terminal domain

Tgene

CLTCL1

chr22:45404426

chr22:19230459

ENST00000353891

68_107

173.0

1665.0

Region

Note=WD40-like repeat 2

Tgene

CLTCL1

chr22:45404426

chr22:19230459

ENST00000427926

108_149

173.0

1710.6666666666667

Region

Note=WD40-like repeat 3

Tgene

CLTCL1

chr22:45404426

chr22:19230459

ENST00000427926

150_195

173.0

1710.6666666666667

Region

Note=WD40-like repeat 4

Tgene

CLTCL1

chr22:45404426

chr22:19230459

ENST00000427926

24_67

173.0

1710.6666666666667

Region

Note=WD40-like repeat 1

Tgene

CLTCL1

chr22:45404426

chr22:19230459

ENST00000427926

2_479

173.0

1710.6666666666667

Region

Note=Globular terminal domain

Tgene

CLTCL1

chr22:45404426

chr22:19230459

ENST00000427926

68_107

173.0

1710.6666666666667

Region

Note=WD40-like repeat 2

Top

Fusion Protein-Protein Interaction

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)

Gene

PPI interactors

Protein-protein interactors based on sequence similarity (STRING)

Gene	STRING network
PHF21B
CLTCL1

- Retained interactions in fusion protein (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost interactions due to fusion (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs to PHF21B-CLTCL1

Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Drug

Source

PMID

Top

Related Diseases to PHF21B-CLTCL1

Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Disease

Source

PMID

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source