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Fusion Protein:PICALM-CTSC |
Fusion Protein Summary |
 Fusion gene summary |
| Fusion partner gene information | Fusion gene name: PICALM-CTSC | FusionPDB ID: 65146 | FusionGDB2.0 ID: 65146 | Hgene | Tgene | Gene symbol | PICALM | CTSC | Gene ID | 8301 | 1075 |
| Gene name | phosphatidylinositol binding clathrin assembly protein | cathepsin C | |
| Synonyms | CALM|CLTH|LAP | CPPI|DPP-I|DPP1|DPPI|HMS|JP|JPD|PALS|PDON1|PLS | |
| Cytomap | 11q14.2 | 11q14.2 | |
| Type of gene | protein-coding | protein-coding | |
| Description | phosphatidylinositol-binding clathrin assembly proteinclathrin assembly lymphoid myeloid leukemia protein | dipeptidyl peptidase 1cathepsin Jdipeptidyl transferasedipeptidyl-peptidase I | |
| Modification date | 20200322 | 20200313 | |
| UniProtAcc | Q13492 | P53634 | |
| Ensembl transtripts involved in fusion gene | ENST ids | ENST00000356360, ENST00000393346, ENST00000526033, ENST00000532317, ENST00000528411, ENST00000528398, | ENST00000393301, ENST00000524463, ENST00000529974, ENST00000227266, |
| Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0) | * DoF score | 24 X 29 X 9=6264 | 6 X 4 X 4=96 |
| # samples | 39 | 6 | |
| ** MAII score | log2(39/6264*10)=-4.00553818354143 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(6/96*10)=-0.678071905112638 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context (manual curation of fusion genes in FusionPDB) | PubMed: PICALM [Title/Abstract] AND CTSC [Title/Abstract] AND fusion [Title/Abstract] | ||
| Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0) | PICALM(85779693)-CTSC(88045722), # samples:1 | ||
| Anticipated loss of major functional domain due to fusion event. | PICALM-CTSC seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. PICALM-CTSC seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | PICALM | GO:0006897 | endocytosis | 22118466 |
| Hgene | PICALM | GO:0006898 | receptor-mediated endocytosis | 10436022 |
| Hgene | PICALM | GO:0032880 | regulation of protein localization | 10436022 |
| Hgene | PICALM | GO:0045893 | positive regulation of transcription, DNA-templated | 11425879 |
| Hgene | PICALM | GO:0048261 | negative regulation of receptor-mediated endocytosis | 10436022 |
| Hgene | PICALM | GO:1905224 | clathrin-coated pit assembly | 16262731 |
| Tgene | CTSC | GO:0006508 | proteolysis | 8811434 |
| Fusion gene breakpoints across PICALM (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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| Fusion gene breakpoints across CTSC (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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Fusion Gene Sample Information |
| Fusion gene information from FusionGDB2.0. |
| Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChimerDB4 | STAD | TCGA-D7-A4Z0-01A | PICALM | chr11 | 85779693 | - | CTSC | chr11 | 88045722 | - |
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Fusion ORF Analysis |
| Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
| ENST00000532317 | PICALM | chr11 | 85779693 | - | ENST00000227266 | CTSC | chr11 | 88045722 | - | 1897 | 409 | 310 | 1482 | 390 |
| ENST00000526033 | PICALM | chr11 | 85779693 | - | ENST00000227266 | CTSC | chr11 | 88045722 | - | 1935 | 447 | 348 | 1520 | 390 |
| ENST00000393346 | PICALM | chr11 | 85779693 | - | ENST00000227266 | CTSC | chr11 | 88045722 | - | 1767 | 279 | 180 | 1352 | 390 |
| ENST00000356360 | PICALM | chr11 | 85779693 | - | ENST00000227266 | CTSC | chr11 | 88045722 | - | 1618 | 130 | 31 | 1203 | 390 |
| DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
| ENST00000532317 | ENST00000227266 | PICALM | chr11 | 85779693 | - | CTSC | chr11 | 88045722 | - | 0.001631823 | 0.9983682 |
| ENST00000526033 | ENST00000227266 | PICALM | chr11 | 85779693 | - | CTSC | chr11 | 88045722 | - | 0.001677753 | 0.9983222 |
| ENST00000393346 | ENST00000227266 | PICALM | chr11 | 85779693 | - | CTSC | chr11 | 88045722 | - | 0.001493009 | 0.99850696 |
| ENST00000356360 | ENST00000227266 | PICALM | chr11 | 85779693 | - | CTSC | chr11 | 88045722 | - | 0.001235901 | 0.99876416 |
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Fusion Amino Acid Sequences |
| For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
| >FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP >65146_65146_1_PICALM-CTSC_PICALM_chr11_85779693_ENST00000356360_CTSC_chr11_88045722_ENST00000227266_length(amino acids)=390AA_BP=33 MPPSTVSPALPYPRQYARPRPTRSWGPRKSTWTYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKY SNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQA SCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSS EYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGW -------------------------------------------------------------- >65146_65146_2_PICALM-CTSC_PICALM_chr11_85779693_ENST00000393346_CTSC_chr11_88045722_ENST00000227266_length(amino acids)=390AA_BP=33 MPPSTVSPALPYPRQYARPRPTRSWGPRKSTWTYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKY SNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQA SCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSS EYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGW -------------------------------------------------------------- >65146_65146_3_PICALM-CTSC_PICALM_chr11_85779693_ENST00000526033_CTSC_chr11_88045722_ENST00000227266_length(amino acids)=390AA_BP=33 MPPSTVSPALPYPRQYARPRPTRSWGPRKSTWTYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKY SNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQA SCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSS EYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGW -------------------------------------------------------------- >65146_65146_4_PICALM-CTSC_PICALM_chr11_85779693_ENST00000532317_CTSC_chr11_88045722_ENST00000227266_length(amino acids)=390AA_BP=33 MPPSTVSPALPYPRQYARPRPTRSWGPRKSTWTYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKY SNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQA SCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSS EYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGW -------------------------------------------------------------- |
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Fusion Protein Functional Features |
| Four levels of functional features of fusion genes Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr11:85779693/chr11:88045722) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
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| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| PICALM | CTSC |
| FUNCTION: Cytoplasmic adapter protein that plays a critical role in clathrin-mediated endocytosis which is important in processes such as internalization of cell receptors, synaptic transmission or removal of apoptotic cells. Recruits AP-2 and attaches clathrin triskelions to the cytoplasmic side of plasma membrane leading to clathrin-coated vesicles (CCVs) assembly (PubMed:10436022, PubMed:16262731, PubMed:27574975). Furthermore, regulates clathrin-coated vesicle size and maturation by directly sensing and driving membrane curvature (PubMed:25898166). In addition to binding to clathrin, mediates the endocytosis of small R-SNARES (Soluble NSF Attachment Protein REceptors) between plasma membranes and endosomes including VAMP2, VAMP3, VAMP4, VAMP7 or VAMP8 (PubMed:22118466, PubMed:21808019, PubMed:23741335). In turn, PICALM-dependent SNARE endocytosis is required for the formation and maturation of autophagic precursors (PubMed:25241929). Modulates thereby autophagy and the turnover of autophagy substrates such as MAPT/TAU or amyloid precursor protein cleaved C-terminal fragment (APP-CTF) (PubMed:25241929, PubMed:24067654). {ECO:0000269|PubMed:10436022, ECO:0000269|PubMed:16262731, ECO:0000269|PubMed:21808019, ECO:0000269|PubMed:22118466, ECO:0000269|PubMed:23741335, ECO:0000269|PubMed:24067654, ECO:0000269|PubMed:25241929, ECO:0000269|PubMed:25898166, ECO:0000269|PubMed:27574975}. | FUNCTION: Thiol protease. Has dipeptidylpeptidase activity. Active against a broad range of dipeptide substrates composed of both polar and hydrophobic amino acids. Proline cannot occupy the P1 position and arginine cannot occupy the P2 position of the substrate. Can act as both an exopeptidase and endopeptidase. Activates serine proteases such as elastase, cathepsin G and granzymes A and B. Can also activate neuraminidase and factor XIII. {ECO:0000269|PubMed:1586157}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
| - Retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - Not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | PICALM | chr11:85779693 | chr11:88045722 | ENST00000356360 | - | 1 | 19 | 14_145 | 43.333333333333336 | 633.0 | Domain | ENTH |
| Hgene | PICALM | chr11:85779693 | chr11:88045722 | ENST00000393346 | - | 1 | 20 | 14_145 | 43.333333333333336 | 653.0 | Domain | ENTH |
| Hgene | PICALM | chr11:85779693 | chr11:88045722 | ENST00000526033 | - | 1 | 20 | 14_145 | 43.333333333333336 | 646.0 | Domain | ENTH |
| Hgene | PICALM | chr11:85779693 | chr11:88045722 | ENST00000528398 | - | 1 | 19 | 14_145 | 0 | 552.0 | Domain | ENTH |
| Hgene | PICALM | chr11:85779693 | chr11:88045722 | ENST00000532317 | - | 1 | 20 | 14_145 | 43.333333333333336 | 611.0 | Domain | ENTH |
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Fusion Protein-Protein Interaction |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in |
| Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160) |
| Gene | PPI interactors |
| PICALM | PLCG1, CLTC, ITSN1, AP2A1, HIP1R, LAMTOR3, EEF1A1, SEC24D, DNM2, EGFR, FLOT1, SEC24C, ATP6V1E1, ILF3, HNRNPDL, SH3GLB2, ABCC2, ATP6V1F, CD55, SIRT1, FN1, VCAM1, ITGA4, PELI2, KLHL20, SLC25A41, ITLN1, ATF6B, SLC25A32, SOX2, FAM64A, CYP1A1, HNRNPA1, UNK, NTRK1, C14orf166, CARS, CPPED1, HNRNPD, ILVBL, ITGB1, LPP, PAPOLA, DDX1, EWSR1, FERMT2, FUS, ILK, NPLOC4, PFKM, PTPRF, VCL, PXN, STXBP1, TRIM25, UNC13D, XPO1, AP2B1, AP2M1, CLTA, CLTB, DAB2, EPS15, GAK, MYO6, PIK3C2A, SEC13, CLTCL1, CAPZA2, DBN1, MYH9, LIMA1, GTSE1, ANLN, MYO19, MYO18A, CLINT1, SEC16A, TNRC6A, BMP2K, MICAL3, DENND1A, WNK1, PRRC2B, STON2, FCHO2, Actb, Myh9, Myo1c, Tpm1, Lima1, Calml3, Sec24c, MCM2, SNW1, CDC5L, SMURF1, CDH1, STAMBPL1, RALBP1, SNRNP27, DLST, FCHO1, RBPMS, CRX, AGR2, CDK9, TGOLN2, ATG16L1, MAP1LC3A, DYRK1A, APEX1, SCARB2, VMP1, MTMR4, TENM1, ATXN1, ZC3H10, ATXN1L, PLEKHA4, ORF6, ORF3a, SMAP2, CIT, ECT2, KIF14, KIF20A, MKI67, HNRNPH1, CDC42, Rnf183, E, WDR76, GGA2, FAM20C, OGT, ISG15, ARF6, B3GAT1, C11orf52, DIRAS3, GJA1, KRAS, LAMP2, LAMP3, LAMTOR1, MARCKS, OCLN, RAB35, RHOB, STX6, STX7, SYNE3, ZFPL1, NAA40, PIP, SNAP91, MTSS1L, BAG2, DDX3Y, ZBTB2, DNAJB6, PINK1, WIF1, ZNF444, CCR1, CENPQ, DOK4, ST3GAL5, BBS1, RBM47, C10orf88, NTNG1, C11orf49, DNAJC6, MBNL1, RDH11, MED17, POGZ, SERBP1, RBM38, FSCN1, IFITM1, IFITM3, ACE2, M, nsp14, DDX3X, |
| Protein-protein interactors based on sequence similarity (STRING) |
| Gene | STRING network |
| PICALM |  |
| CTSC |
| - Retained interactions in fusion protein (protein functional feature from UniProt). |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost interactions due to fusion (protein functional feature from UniProt). |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| Hgene | PICALM | chr11:85779693 | chr11:88045722 | ENST00000356360 | - | 1 | 19 | 221_294 | 43.333333333333336 | 633.0 | PIMREG |
| Hgene | PICALM | chr11:85779693 | chr11:88045722 | ENST00000393346 | - | 1 | 20 | 221_294 | 43.333333333333336 | 653.0 | PIMREG |
| Hgene | PICALM | chr11:85779693 | chr11:88045722 | ENST00000526033 | - | 1 | 20 | 221_294 | 43.333333333333336 | 646.0 | PIMREG |
| Hgene | PICALM | chr11:85779693 | chr11:88045722 | ENST00000528398 | - | 1 | 19 | 221_294 | 0 | 552.0 | PIMREG |
| Hgene | PICALM | chr11:85779693 | chr11:88045722 | ENST00000532317 | - | 1 | 20 | 221_294 | 43.333333333333336 | 611.0 | PIMREG |
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Related Drugs to PICALM-CTSC |
| Drugs used for this fusion-positive patient. (Manual curation of PubMed, 04-30-2022 + MyCancerGenome) |
| Hgene | Tgene | Drug | Source | PMID |
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Related Diseases to PICALM-CTSC |
| Diseases that have this fusion gene. (Manual curation of PubMed, 04-30-2022 + MyCancerGenome) |
| Hgene | Tgene | Disease | Source | PMID |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | PICALM | C0002395 | Alzheimer's Disease | 2 | CTD_human |
| Hgene | PICALM | C0011265 | Presenile dementia | 2 | CTD_human |
| Hgene | PICALM | C0276496 | Familial Alzheimer Disease (FAD) | 2 | CTD_human |
| Hgene | PICALM | C0494463 | Alzheimer Disease, Late Onset | 2 | CTD_human |
| Hgene | PICALM | C0546126 | Acute Confusional Senile Dementia | 2 | CTD_human |
| Hgene | PICALM | C0750900 | Alzheimer's Disease, Focal Onset | 2 | CTD_human |
| Hgene | PICALM | C0750901 | Alzheimer Disease, Early Onset | 2 | CTD_human |
| Hgene | PICALM | C0234985 | Mental deterioration | 1 | CTD_human |
| Hgene | PICALM | C0338656 | Impaired cognition | 1 | CTD_human |
| Hgene | PICALM | C1270972 | Mild cognitive disorder | 1 | CTD_human |
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