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Center for Computational Systems Medicine level1
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:PIGU-PTPRT

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: PIGU-PTPRT
FusionPDB ID: 65312
FusionGDB2.0 ID: 65312
HgeneTgene
Gene symbol

PIGU

PTPRT

Gene ID

128869

11122

Gene namephosphatidylinositol glycan anchor biosynthesis class Uprotein tyrosine phosphatase receptor type T
SynonymsCDC91L1|GAB1|GPIBD21RPTPrho
Cytomap

20q11.22

20q12-q13.11

Type of geneprotein-codingprotein-coding
Descriptionphosphatidylinositol glycan anchor biosynthesis class U proteinCDC91 (cell division cycle 91, S. cerevisiae, homolog)-like 1GPI transamidase component PIG-UGPI transamidase subunitcell division cycle 91-like 1 proteincell division cycle protein 91-lireceptor-type tyrosine-protein phosphatase TR-PTP-TRPTP-rhoreceptor protein tyrosine phosphatasereceptor-type tyrosine-protein phosphatase rho
Modification date2020032220200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST idsENST00000374820, ENST00000452740, 
ENST00000480175, 
ENST00000485499, 
ENST00000356100, ENST00000373184, 
ENST00000373187, ENST00000373190, 
ENST00000373193, ENST00000373198, 
ENST00000373201, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score18 X 13 X 10=234025 X 24 X 7=4200
# samples 2027
** MAII scorelog2(20/2340*10)=-3.54843662469604
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(27/4200*10)=-3.95935801550265
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: PIGU [Title/Abstract] AND PTPRT [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)PIGU(33162908)-PTPRT(40911165), # samples:2
Anticipated loss of major functional domain due to fusion event.PIGU-PTPRT seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
PIGU-PTPRT seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
PIGU-PTPRT seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
PIGU-PTPRT seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
PIGU-PTPRT seems lost the major protein functional domain in Hgene partner, which is a cell metabolism gene due to the frame-shifted ORF.
PIGU-PTPRT seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
PIGU-PTPRT seems lost the major protein functional domain in Tgene partner, which is a CGC due to the frame-shifted ORF.
PIGU-PTPRT seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
PIGU-PTPRT seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
PIGU-PTPRT seems lost the major protein functional domain in Tgene partner, which is a tumor suppressor due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgenePIGU

GO:0006506

GPI anchor biosynthetic process

15034568

HgenePIGU

GO:0046425

regulation of JAK-STAT cascade

15034568

TgenePTPRT

GO:0006470

protein dephosphorylation

16973135

TgenePTPRT

GO:0007156

homophilic cell adhesion via plasma membrane adhesion molecules

18644975

TgenePTPRT

GO:0035335

peptidyl-tyrosine dephosphorylation

17360477

TgenePTPRT

GO:0071354

cellular response to interleukin-6

17360477

TgenePTPRT

GO:1904893

negative regulation of STAT cascade

17360477

TgenePTPRT

GO:1990264

peptidyl-tyrosine dephosphorylation involved in inactivation of protein kinase activity

24846175


check buttonFusion gene breakpoints across PIGU (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across PTPRT (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-E2-A1B1-01APIGUchr20

33162908

-PTPRTchr20

40911165

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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)
BP loci
(transcript)
Predicted start
(transcript)
Predicted stop
(transcript)
Seq length
(amino acids)
ENST00000374820PIGUchr2033162908-ENST00000373184PTPRTchr2040911165-1149911552133711116
ENST00000374820PIGUchr2033162908-ENST00000373187PTPRTchr2040911165-1146911552133411106
ENST00000374820PIGUchr2033162908-ENST00000356100PTPRTchr2040911165-1149611552133681115
ENST00000374820PIGUchr2033162908-ENST00000373190PTPRTchr2040911165-1146611552133381105
ENST00000374820PIGUchr2033162908-ENST00000373193PTPRTchr2040911165-1147811552133501109
ENST00000374820PIGUchr2033162908-ENST00000373198PTPRTchr2040911165-1152611552133981125
ENST00000374820PIGUchr2033162908-ENST00000373201PTPRTchr2040911165-1143911552133111096

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000374820ENST00000373184PIGUchr2033162908-PTPRTchr2040911165-0.0003917330.99960834
ENST00000374820ENST00000373187PIGUchr2033162908-PTPRTchr2040911165-0.0005205310.9994795
ENST00000374820ENST00000356100PIGUchr2033162908-PTPRTchr2040911165-0.0004699790.9995301
ENST00000374820ENST00000373190PIGUchr2033162908-PTPRTchr2040911165-0.0004569370.9995431
ENST00000374820ENST00000373193PIGUchr2033162908-PTPRTchr2040911165-0.0005377320.9994623
ENST00000374820ENST00000373198PIGUchr2033162908-PTPRTchr2040911165-0.0004089020.99959105
ENST00000374820ENST00000373201PIGUchr2033162908-PTPRTchr2040911165-0.000469360.9995307

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>65312_65312_1_PIGU-PTPRT_PIGU_chr20_33162908_ENST00000374820_PTPRT_chr20_40911165_ENST00000356100_length(amino acids)=1115AA_BP=377
MAAPLVLVLVVAVTVRAALFRSSLAEFISERVEVVSPLSSWKRVVEGLSLLDLGVSPYSGAVFHEITDALTAIALYFAIQDFNKVVFKKQ
KLLLELDQYAPDVAELIRTPMEMRYIPLKVALFYLLNPYTILSCVAKSTCAINNTLIAFFILTTIKGSAFLSAIFLALATYQSLYPLTLF
VPGLLYLLQRQYIPVKMKSKAFWIFSWEYAMMYVGSLVVIICLSFFLLSSWDFIPAVYGFILSVPDLTPNIGLFWYFFAEMFEHFSLFFV
CVFQINVFFYTIPLAIKLKEHPIFFMFIQIAVIAIFKSYPTVGDVALYMAFFPVWNHLYRFLRNIFVLTCIIIVCSLLFPVLWHLWIYAG
SANSNFFYAITLTFNVGQETKINCVRLATKAPMGSAQVTPGTPLCLLTTGASTQNSNTVEPEKQVDNTVKMAGVIAGLLMFIIILLGVML
TIKRRKLAKKQKETQSGAQREMGPVASADKPTTKLSASRNDEGFSSSSQDVNGFTDGSRGELSQPTLTIQTHPYRTCDPVEMSYPRDQFQ
PAIRVADLLQHITQMKRGQGYGFKEEYEALPEGQTASWDTAKEDENRNKNRYGNIISYDHSRVRLLVLDGDPHSDYINANYIDGYHRPRH
YIATQGPMQETVKDFWRMIWQENSASIVMVTNLVEVGRVKCVRYWPDDTEVYGDIKVTLIETEPLAEYVIRTFTVQKKGYHEIRELRLFH
FTSWPDHGVPCYATGLLGFVRQVKFLNPPEAGPIVVHCSAGAGRTGCFIAIDTMLDMAENEGVVDIFNCVRELRAQRVNLVQTEEQYVFV
HDAILEACLCGNTAIPVCEFRSLYYNISRLDPQTNSSQIKDEFQTLNIVTPRVRPEDCSIGLLPRNHDKNRSMDVLPLDRCLPFLISVDG
ESSNYINAALMDSHKQPAAFVVTQHPLPNTVADFWRLVFDYNCSSVVMLNEMDTAQFCMQYWPEKTSGCYGPIQVEFVSADIDEDIIHRI
FRICNMARPQDGYRIVQHLQYIGWPAYRDTPPSKRSLLKVVRRLEKWQEQYDGREGRTVVHCLNGGGRSGTFCAICSVCEMIQQQNIIDV

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>65312_65312_2_PIGU-PTPRT_PIGU_chr20_33162908_ENST00000374820_PTPRT_chr20_40911165_ENST00000373184_length(amino acids)=1116AA_BP=377
MAAPLVLVLVVAVTVRAALFRSSLAEFISERVEVVSPLSSWKRVVEGLSLLDLGVSPYSGAVFHEITDALTAIALYFAIQDFNKVVFKKQ
KLLLELDQYAPDVAELIRTPMEMRYIPLKVALFYLLNPYTILSCVAKSTCAINNTLIAFFILTTIKGSAFLSAIFLALATYQSLYPLTLF
VPGLLYLLQRQYIPVKMKSKAFWIFSWEYAMMYVGSLVVIICLSFFLLSSWDFIPAVYGFILSVPDLTPNIGLFWYFFAEMFEHFSLFFV
CVFQINVFFYTIPLAIKLKEHPIFFMFIQIAVIAIFKSYPTVGDVALYMAFFPVWNHLYRFLRNIFVLTCIIIVCSLLFPVLWHLWIYAG
SANSNFFYAITLTFNVGQETKINCVRLATKGASTQNSNTVEPEKQVDNTVKMAGVIAGLLMFIIILLGVMLTIKRRKLAKKQKETQSGAQ
REMGPVASADKPTTKLSASRNDEGFSSSSQDVNGFTDGSRGELSQPTLTIQTHPYRTCDPVEMSYPRDQFQPAIRVADLLQHITQMKRGQ
GYGFKEEYEALPEGQTASWDTAKEDENRNKNRYGNIISYDHSRVRLLVLDGDPHSDYINANYIDGYHRPRHYIATQGPMQETVKDFWRMI
WQENSASIVMVTNLVEVGRHPAEHTVGNATLGRAASPGMVKCVRYWPDDTEVYGDIKVTLIETEPLAEYVIRTFTVQKKGYHEIRELRLF
HFTSWPDHGVPCYATGLLGFVRQVKFLNPPEAGPIVVHCSAGAGRTGCFIAIDTMLDMAENEGVVDIFNCVRELRAQRVNLVQTEEQYVF
VHDAILEACLCGNTAIPVCEFRSLYYNISRLDPQTNSSQIKDEFQTLNIVTPRVRPEDCSIGLLPRNHDKNRSMDVLPLDRCLPFLISVD
GESSNYINAALMDSHKQPAAFVVTQHPLPNTVADFWRLVFDYNCSSVVMLNEMDTAQFCMQYWPEKTSGCYGPIQVEFVSADIDEDIIHR
IFRICNMARPQDGYRIVQHLQYIGWPAYRDTPPSKRSLLKVVRRLEKWQEQYDGREGRTVVHCLNGGGRSGTFCAICSVCEMIQQQNIID

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>65312_65312_3_PIGU-PTPRT_PIGU_chr20_33162908_ENST00000374820_PTPRT_chr20_40911165_ENST00000373187_length(amino acids)=1106AA_BP=377
MAAPLVLVLVVAVTVRAALFRSSLAEFISERVEVVSPLSSWKRVVEGLSLLDLGVSPYSGAVFHEITDALTAIALYFAIQDFNKVVFKKQ
KLLLELDQYAPDVAELIRTPMEMRYIPLKVALFYLLNPYTILSCVAKSTCAINNTLIAFFILTTIKGSAFLSAIFLALATYQSLYPLTLF
VPGLLYLLQRQYIPVKMKSKAFWIFSWEYAMMYVGSLVVIICLSFFLLSSWDFIPAVYGFILSVPDLTPNIGLFWYFFAEMFEHFSLFFV
CVFQINVFFYTIPLAIKLKEHPIFFMFIQIAVIAIFKSYPTVGDVALYMAFFPVWNHLYRFLRNIFVLTCIIIVCSLLFPVLWHLWIYAG
SANSNFFYAITLTFNVGQETKINCVRLATKGASTQNSNTVEPEKQVDNTVKMAGVIAGLLMFIIILLGVMLTIKRRRNAYSYSYYLKLAK
KQKETQSGAQREMGPVASADKPTTKLSASRNDEGFSSSSQDVNGFTDGSRGELSQPTLTIQTHPYRTCDPVEMSYPRDQFQPAIRVADLL
QHITQMKRGQGYGFKEEYEALPEGQTASWDTAKEDENRNKNRYGNIISYDHSRVRLLVLDGDPHSDYINANYIDGYHRPRHYIATQGPMQ
ETVKDFWRMIWQENSASIVMVTNLVEVGRVKCVRYWPDDTEVYGDIKVTLIETEPLAEYVIRTFTVQKKGYHEIRELRLFHFTSWPDHGV
PCYATGLLGFVRQVKFLNPPEAGPIVVHCSAGAGRTGCFIAIDTMLDMAENEGVVDIFNCVRELRAQRVNLVQTEEQYVFVHDAILEACL
CGNTAIPVCEFRSLYYNISRLDPQTNSSQIKDEFQTLNIVTPRVRPEDCSIGLLPRNHDKNRSMDVLPLDRCLPFLISVDGESSNYINAA
LMDSHKQPAAFVVTQHPLPNTVADFWRLVFDYNCSSVVMLNEMDTAQFCMQYWPEKTSGCYGPIQVEFVSADIDEDIIHRIFRICNMARP
QDGYRIVQHLQYIGWPAYRDTPPSKRSLLKVVRRLEKWQEQYDGREGRTVVHCLNGGGRSGTFCAICSVCEMIQQQNIIDVFHIVKTLRN

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>65312_65312_4_PIGU-PTPRT_PIGU_chr20_33162908_ENST00000374820_PTPRT_chr20_40911165_ENST00000373190_length(amino acids)=1105AA_BP=377
MAAPLVLVLVVAVTVRAALFRSSLAEFISERVEVVSPLSSWKRVVEGLSLLDLGVSPYSGAVFHEITDALTAIALYFAIQDFNKVVFKKQ
KLLLELDQYAPDVAELIRTPMEMRYIPLKVALFYLLNPYTILSCVAKSTCAINNTLIAFFILTTIKGSAFLSAIFLALATYQSLYPLTLF
VPGLLYLLQRQYIPVKMKSKAFWIFSWEYAMMYVGSLVVIICLSFFLLSSWDFIPAVYGFILSVPDLTPNIGLFWYFFAEMFEHFSLFFV
CVFQINVFFYTIPLAIKLKEHPIFFMFIQIAVIAIFKSYPTVGDVALYMAFFPVWNHLYRFLRNIFVLTCIIIVCSLLFPVLWHLWIYAG
SANSNFFYAITLTFNVGQETKINCVRLATKGASTQNSNTVEPEKQVDNTVKMAGVIAGLLMFIIILLGVMLTIKRRRNAYSYSYYLKLAK
KQKETQSGAQREMGPVASADKPTTKLSASRNDEGFSSSSQDVNGFNGSRGELSQPTLTIQTHPYRTCDPVEMSYPRDQFQPAIRVADLLQ
HITQMKRGQGYGFKEEYEALPEGQTASWDTAKEDENRNKNRYGNIISYDHSRVRLLVLDGDPHSDYINANYIDGYHRPRHYIATQGPMQE
TVKDFWRMIWQENSASIVMVTNLVEVGRVKCVRYWPDDTEVYGDIKVTLIETEPLAEYVIRTFTVQKKGYHEIRELRLFHFTSWPDHGVP
CYATGLLGFVRQVKFLNPPEAGPIVVHCSAGAGRTGCFIAIDTMLDMAENEGVVDIFNCVRELRAQRVNLVQTEEQYVFVHDAILEACLC
GNTAIPVCEFRSLYYNISRLDPQTNSSQIKDEFQTLNIVTPRVRPEDCSIGLLPRNHDKNRSMDVLPLDRCLPFLISVDGESSNYINAAL
MDSHKQPAAFVVTQHPLPNTVADFWRLVFDYNCSSVVMLNEMDTAQFCMQYWPEKTSGCYGPIQVEFVSADIDEDIIHRIFRICNMARPQ
DGYRIVQHLQYIGWPAYRDTPPSKRSLLKVVRRLEKWQEQYDGREGRTVVHCLNGGGRSGTFCAICSVCEMIQQQNIIDVFHIVKTLRNN

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>65312_65312_5_PIGU-PTPRT_PIGU_chr20_33162908_ENST00000374820_PTPRT_chr20_40911165_ENST00000373193_length(amino acids)=1109AA_BP=377
MAAPLVLVLVVAVTVRAALFRSSLAEFISERVEVVSPLSSWKRVVEGLSLLDLGVSPYSGAVFHEITDALTAIALYFAIQDFNKVVFKKQ
KLLLELDQYAPDVAELIRTPMEMRYIPLKVALFYLLNPYTILSCVAKSTCAINNTLIAFFILTTIKGSAFLSAIFLALATYQSLYPLTLF
VPGLLYLLQRQYIPVKMKSKAFWIFSWEYAMMYVGSLVVIICLSFFLLSSWDFIPAVYGFILSVPDLTPNIGLFWYFFAEMFEHFSLFFV
CVFQINVFFYTIPLAIKLKEHPIFFMFIQIAVIAIFKSYPTVGDVALYMAFFPVWNHLYRFLRNIFVLTCIIIVCSLLFPVLWHLWIYAG
SANSNFFYAITLTFNVGQETKINCVRLATKGASTQNSNTVEPEKQVDNTVKMAGVIAGLLMFIIILLGVMLTIKRRRNAYSYSYYLSQRK
LAKKQKETQSGAQREMGPVASADKPTTKLSASRNDEGFSSSSQDVNGFTDGSRGELSQPTLTIQTHPYRTCDPVEMSYPRDQFQPAIRVA
DLLQHITQMKRGQGYGFKEEYEALPEGQTASWDTAKEDENRNKNRYGNIISYDHSRVRLLVLDGDPHSDYINANYIDGYHRPRHYIATQG
PMQETVKDFWRMIWQENSASIVMVTNLVEVGRVKCVRYWPDDTEVYGDIKVTLIETEPLAEYVIRTFTVQKKGYHEIRELRLFHFTSWPD
HGVPCYATGLLGFVRQVKFLNPPEAGPIVVHCSAGAGRTGCFIAIDTMLDMAENEGVVDIFNCVRELRAQRVNLVQTEEQYVFVHDAILE
ACLCGNTAIPVCEFRSLYYNISRLDPQTNSSQIKDEFQTLNIVTPRVRPEDCSIGLLPRNHDKNRSMDVLPLDRCLPFLISVDGESSNYI
NAALMDSHKQPAAFVVTQHPLPNTVADFWRLVFDYNCSSVVMLNEMDTAQFCMQYWPEKTSGCYGPIQVEFVSADIDEDIIHRIFRICNM
ARPQDGYRIVQHLQYIGWPAYRDTPPSKRSLLKVVRRLEKWQEQYDGREGRTVVHCLNGGGRSGTFCAICSVCEMIQQQNIIDVFHIVKT

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>65312_65312_6_PIGU-PTPRT_PIGU_chr20_33162908_ENST00000374820_PTPRT_chr20_40911165_ENST00000373198_length(amino acids)=1125AA_BP=377
MAAPLVLVLVVAVTVRAALFRSSLAEFISERVEVVSPLSSWKRVVEGLSLLDLGVSPYSGAVFHEITDALTAIALYFAIQDFNKVVFKKQ
KLLLELDQYAPDVAELIRTPMEMRYIPLKVALFYLLNPYTILSCVAKSTCAINNTLIAFFILTTIKGSAFLSAIFLALATYQSLYPLTLF
VPGLLYLLQRQYIPVKMKSKAFWIFSWEYAMMYVGSLVVIICLSFFLLSSWDFIPAVYGFILSVPDLTPNIGLFWYFFAEMFEHFSLFFV
CVFQINVFFYTIPLAIKLKEHPIFFMFIQIAVIAIFKSYPTVGDVALYMAFFPVWNHLYRFLRNIFVLTCIIIVCSLLFPVLWHLWIYAG
SANSNFFYAITLTFNVGQETKINCVRLATKAPMGSAQVTPGTPLCLLTTGASTQNSNTVEPEKQVDNTVKMAGVIAGLLMFIIILLGVML
TIKRRRNAYSYSYYLKLAKKQKETQSGAQREMGPVASADKPTTKLSASRNDEGFSSSSQDVNGFTDGSRGELSQPTLTIQTHPYRTCDPV
EMSYPRDQFQPAIRVADLLQHITQMKRGQGYGFKEEYEALPEGQTASWDTAKEDENRNKNRYGNIISYDHSRVRLLVLDGDPHSDYINAN
YIDGYHRPRHYIATQGPMQETVKDFWRMIWQENSASIVMVTNLVEVGRVKCVRYWPDDTEVYGDIKVTLIETEPLAEYVIRTFTVQKKGY
HEIRELRLFHFTSWPDHGVPCYATGLLGFVRQVKFLNPPEAGPIVVHCSAGAGRTGCFIAIDTMLDMAENEGVVDIFNCVRELRAQRVNL
VQTEEQYVFVHDAILEACLCGNTAIPVCEFRSLYYNISRLDPQTNSSQIKDEFQTLNIVTPRVRPEDCSIGLLPRNHDKNRSMDVLPLDR
CLPFLISVDGESSNYINAALMDSHKQPAAFVVTQHPLPNTVADFWRLVFDYNCSSVVMLNEMDTAQFCMQYWPEKTSGCYGPIQVEFVSA
DIDEDIIHRIFRICNMARPQDGYRIVQHLQYIGWPAYRDTPPSKRSLLKVVRRLEKWQEQYDGREGRTVVHCLNGGGRSGTFCAICSVCE

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>65312_65312_7_PIGU-PTPRT_PIGU_chr20_33162908_ENST00000374820_PTPRT_chr20_40911165_ENST00000373201_length(amino acids)=1096AA_BP=377
MAAPLVLVLVVAVTVRAALFRSSLAEFISERVEVVSPLSSWKRVVEGLSLLDLGVSPYSGAVFHEITDALTAIALYFAIQDFNKVVFKKQ
KLLLELDQYAPDVAELIRTPMEMRYIPLKVALFYLLNPYTILSCVAKSTCAINNTLIAFFILTTIKGSAFLSAIFLALATYQSLYPLTLF
VPGLLYLLQRQYIPVKMKSKAFWIFSWEYAMMYVGSLVVIICLSFFLLSSWDFIPAVYGFILSVPDLTPNIGLFWYFFAEMFEHFSLFFV
CVFQINVFFYTIPLAIKLKEHPIFFMFIQIAVIAIFKSYPTVGDVALYMAFFPVWNHLYRFLRNIFVLTCIIIVCSLLFPVLWHLWIYAG
SANSNFFYAITLTFNVGQETKINCVRLATKGASTQNSNTVEPEKQVDNTVKMAGVIAGLLMFIIILLGVMLTIKRRKLAKKQKETQSGAQ
REMGPVASADKPTTKLSASRNDEGFSSSSQDVNGFTDGSRGELSQPTLTIQTHPYRTCDPVEMSYPRDQFQPAIRVADLLQHITQMKRGQ
GYGFKEEYEALPEGQTASWDTAKEDENRNKNRYGNIISYDHSRVRLLVLDGDPHSDYINANYIDGYHRPRHYIATQGPMQETVKDFWRMI
WQENSASIVMVTNLVEVGRVKCVRYWPDDTEVYGDIKVTLIETEPLAEYVIRTFTVQKKGYHEIRELRLFHFTSWPDHGVPCYATGLLGF
VRQVKFLNPPEAGPIVVHCSAGAGRTGCFIAIDTMLDMAENEGVVDIFNCVRELRAQRVNLVQTEEQYVFVHDAILEACLCGNTAIPVCE
FRSLYYNISRLDPQTNSSQIKDEFQTLNIVTPRVRPEDCSIGLLPRNHDKNRSMDVLPLDRCLPFLISVDGESSNYINAALMDSHKQPAA
FVVTQHPLPNTVADFWRLVFDYNCSSVVMLNEMDTAQFCMQYWPEKTSGCYGPIQVEFVSADIDEDIIHRIFRICNMARPQDGYRIVQHL
QYIGWPAYRDTPPSKRSLLKVVRRLEKWQEQYDGREGRTVVHCLNGGGRSGTFCAICSVCEMIQQQNIIDVFHIVKTLRNNKSNMVETLE

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr20:33162908/chr20:40911165)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePIGUchr20:33162908chr20:40911165ENST00000374820-1011269_289378.0416.0RegionNote=May be involved in recognition of long-chain fatty acids in GPI
HgenePIGUchr20:33162908chr20:40911165ENST00000374820-1011166_186378.0416.0TransmembraneHelical
HgenePIGUchr20:33162908chr20:40911165ENST00000374820-1011188_208378.0416.0TransmembraneHelical
HgenePIGUchr20:33162908chr20:40911165ENST00000374820-1011237_257378.0416.0TransmembraneHelical
HgenePIGUchr20:33162908chr20:40911165ENST00000374820-1011259_279378.0416.0TransmembraneHelical
HgenePIGUchr20:33162908chr20:40911165ENST00000374820-1011286_306378.0416.0TransmembraneHelical
HgenePIGUchr20:33162908chr20:40911165ENST00000374820-1011313_333378.0416.0TransmembraneHelical
HgenePIGUchr20:33162908chr20:40911165ENST00000374820-1011355_375378.0416.0TransmembraneHelical
HgenePIGUchr20:33162908chr20:40911165ENST00000374820-101166_86378.0416.0TransmembraneHelical
TgenePTPRTchr20:33162908chr20:40911165ENST0000037318711311175_1437713.01442.0DomainTyrosine-protein phosphatase 2
TgenePTPRTchr20:33162908chr20:40911165ENST000003731871131889_1143713.01442.0DomainTyrosine-protein phosphatase 1
TgenePTPRTchr20:33162908chr20:40911165ENST0000037319811321175_1437713.01461.0DomainTyrosine-protein phosphatase 2
TgenePTPRTchr20:33162908chr20:40911165ENST000003731981132889_1143713.01461.0DomainTyrosine-protein phosphatase 1
TgenePTPRTchr20:33162908chr20:40911165ENST0000037318711311084_1090713.01442.0RegionSubstrate binding
TgenePTPRTchr20:33162908chr20:40911165ENST0000037319811321084_1090713.01461.0RegionSubstrate binding
TgenePTPRTchr20:33162908chr20:40911165ENST000003731871131769_1441713.01442.0Topological domainCytoplasmic
TgenePTPRTchr20:33162908chr20:40911165ENST000003731981132769_1441713.01461.0Topological domainCytoplasmic
TgenePTPRTchr20:33162908chr20:40911165ENST000003731871131748_768713.01442.0TransmembraneHelical
TgenePTPRTchr20:33162908chr20:40911165ENST000003731981132748_768713.01461.0TransmembraneHelical

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePIGUchr20:33162908chr20:40911165ENST00000374820-1011386_406378.0416.0TransmembraneHelical
TgenePTPRTchr20:33162908chr20:40911165ENST000003731871131193_284713.01442.0DomainNote=Ig-like C2-type
TgenePTPRTchr20:33162908chr20:40911165ENST000003731871131291_384713.01442.0DomainFibronectin type-III 1
TgenePTPRTchr20:33162908chr20:40911165ENST00000373187113130_191713.01442.0DomainMAM
TgenePTPRTchr20:33162908chr20:40911165ENST000003731871131389_483713.01442.0DomainFibronectin type-III 2
TgenePTPRTchr20:33162908chr20:40911165ENST000003731871131484_590713.01442.0DomainFibronectin type-III 3
TgenePTPRTchr20:33162908chr20:40911165ENST000003731871131591_726713.01442.0DomainFibronectin type-III 4
TgenePTPRTchr20:33162908chr20:40911165ENST000003731981132193_284713.01461.0DomainNote=Ig-like C2-type
TgenePTPRTchr20:33162908chr20:40911165ENST000003731981132291_384713.01461.0DomainFibronectin type-III 1
TgenePTPRTchr20:33162908chr20:40911165ENST00000373198113230_191713.01461.0DomainMAM
TgenePTPRTchr20:33162908chr20:40911165ENST000003731981132389_483713.01461.0DomainFibronectin type-III 2
TgenePTPRTchr20:33162908chr20:40911165ENST000003731981132484_590713.01461.0DomainFibronectin type-III 3
TgenePTPRTchr20:33162908chr20:40911165ENST000003731981132591_726713.01461.0DomainFibronectin type-III 4
TgenePTPRTchr20:33162908chr20:40911165ENST00000373187113126_747713.01442.0Topological domainExtracellular
TgenePTPRTchr20:33162908chr20:40911165ENST00000373198113226_747713.01461.0Topological domainExtracellular


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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
PIGU
PTPRT


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to PIGU-PTPRT


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to PIGU-PTPRT


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource