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Fusion Protein:PIGU-PTPRT |
Fusion Protein Summary |
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Fusion partner gene information | Fusion gene name: PIGU-PTPRT | FusionPDB ID: 65312 | FusionGDB2.0 ID: 65312 | Hgene | Tgene | Gene symbol | PIGU | PTPRT | Gene ID | 128869 | 11122 |
Gene name | phosphatidylinositol glycan anchor biosynthesis class U | protein tyrosine phosphatase receptor type T | |
Synonyms | CDC91L1|GAB1|GPIBD21 | RPTPrho | |
Cytomap | 20q11.22 | 20q12-q13.11 | |
Type of gene | protein-coding | protein-coding | |
Description | phosphatidylinositol glycan anchor biosynthesis class U proteinCDC91 (cell division cycle 91, S. cerevisiae, homolog)-like 1GPI transamidase component PIG-UGPI transamidase subunitcell division cycle 91-like 1 proteincell division cycle protein 91-li | receptor-type tyrosine-protein phosphatase TR-PTP-TRPTP-rhoreceptor protein tyrosine phosphatasereceptor-type tyrosine-protein phosphatase rho | |
Modification date | 20200322 | 20200313 | |
UniProtAcc | . | . | |
Ensembl transtripts involved in fusion gene | ENST ids | ENST00000374820, ENST00000452740, ENST00000480175, | ENST00000485499, ENST00000356100, ENST00000373184, ENST00000373187, ENST00000373190, ENST00000373193, ENST00000373198, ENST00000373201, |
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0) | * DoF score | 18 X 13 X 10=2340 | 25 X 24 X 7=4200 |
# samples | 20 | 27 | |
** MAII score | log2(20/2340*10)=-3.54843662469604 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(27/4200*10)=-3.95935801550265 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context (manual curation of fusion genes in FusionPDB) | PubMed: PIGU [Title/Abstract] AND PTPRT [Title/Abstract] AND fusion [Title/Abstract] | ||
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0) | PIGU(33162908)-PTPRT(40911165), # samples:2 | ||
Anticipated loss of major functional domain due to fusion event. | PIGU-PTPRT seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. PIGU-PTPRT seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. PIGU-PTPRT seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. PIGU-PTPRT seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. PIGU-PTPRT seems lost the major protein functional domain in Hgene partner, which is a cell metabolism gene due to the frame-shifted ORF. PIGU-PTPRT seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF. PIGU-PTPRT seems lost the major protein functional domain in Tgene partner, which is a CGC due to the frame-shifted ORF. PIGU-PTPRT seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF. PIGU-PTPRT seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF. PIGU-PTPRT seems lost the major protein functional domain in Tgene partner, which is a tumor suppressor due to the frame-shifted ORF. |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | PIGU | GO:0006506 | GPI anchor biosynthetic process | 15034568 |
Hgene | PIGU | GO:0046425 | regulation of JAK-STAT cascade | 15034568 |
Tgene | PTPRT | GO:0006470 | protein dephosphorylation | 16973135 |
Tgene | PTPRT | GO:0007156 | homophilic cell adhesion via plasma membrane adhesion molecules | 18644975 |
Tgene | PTPRT | GO:0035335 | peptidyl-tyrosine dephosphorylation | 17360477 |
Tgene | PTPRT | GO:0071354 | cellular response to interleukin-6 | 17360477 |
Tgene | PTPRT | GO:1904893 | negative regulation of STAT cascade | 17360477 |
Tgene | PTPRT | GO:1990264 | peptidyl-tyrosine dephosphorylation involved in inactivation of protein kinase activity | 24846175 |
![]() * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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![]() * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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Fusion Gene Sample Information |
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![]() * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChimerDB4 | BRCA | TCGA-E2-A1B1-01A | PIGU | chr20 | 33162908 | - | PTPRT | chr20 | 40911165 | - |
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Fusion ORF Analysis |
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Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
ENST00000374820 | PIGU | chr20 | 33162908 | - | ENST00000373184 | PTPRT | chr20 | 40911165 | - | 11499 | 1155 | 21 | 3371 | 1116 |
ENST00000374820 | PIGU | chr20 | 33162908 | - | ENST00000373187 | PTPRT | chr20 | 40911165 | - | 11469 | 1155 | 21 | 3341 | 1106 |
ENST00000374820 | PIGU | chr20 | 33162908 | - | ENST00000356100 | PTPRT | chr20 | 40911165 | - | 11496 | 1155 | 21 | 3368 | 1115 |
ENST00000374820 | PIGU | chr20 | 33162908 | - | ENST00000373190 | PTPRT | chr20 | 40911165 | - | 11466 | 1155 | 21 | 3338 | 1105 |
ENST00000374820 | PIGU | chr20 | 33162908 | - | ENST00000373193 | PTPRT | chr20 | 40911165 | - | 11478 | 1155 | 21 | 3350 | 1109 |
ENST00000374820 | PIGU | chr20 | 33162908 | - | ENST00000373198 | PTPRT | chr20 | 40911165 | - | 11526 | 1155 | 21 | 3398 | 1125 |
ENST00000374820 | PIGU | chr20 | 33162908 | - | ENST00000373201 | PTPRT | chr20 | 40911165 | - | 11439 | 1155 | 21 | 3311 | 1096 |
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Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
ENST00000374820 | ENST00000373184 | PIGU | chr20 | 33162908 | - | PTPRT | chr20 | 40911165 | - | 0.000391733 | 0.99960834 |
ENST00000374820 | ENST00000373187 | PIGU | chr20 | 33162908 | - | PTPRT | chr20 | 40911165 | - | 0.000520531 | 0.9994795 |
ENST00000374820 | ENST00000356100 | PIGU | chr20 | 33162908 | - | PTPRT | chr20 | 40911165 | - | 0.000469979 | 0.9995301 |
ENST00000374820 | ENST00000373190 | PIGU | chr20 | 33162908 | - | PTPRT | chr20 | 40911165 | - | 0.000456937 | 0.9995431 |
ENST00000374820 | ENST00000373193 | PIGU | chr20 | 33162908 | - | PTPRT | chr20 | 40911165 | - | 0.000537732 | 0.9994623 |
ENST00000374820 | ENST00000373198 | PIGU | chr20 | 33162908 | - | PTPRT | chr20 | 40911165 | - | 0.000408902 | 0.99959105 |
ENST00000374820 | ENST00000373201 | PIGU | chr20 | 33162908 | - | PTPRT | chr20 | 40911165 | - | 0.00046936 | 0.9995307 |
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Fusion Amino Acid Sequences |
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>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP >65312_65312_1_PIGU-PTPRT_PIGU_chr20_33162908_ENST00000374820_PTPRT_chr20_40911165_ENST00000356100_length(amino acids)=1115AA_BP=377 MAAPLVLVLVVAVTVRAALFRSSLAEFISERVEVVSPLSSWKRVVEGLSLLDLGVSPYSGAVFHEITDALTAIALYFAIQDFNKVVFKKQ KLLLELDQYAPDVAELIRTPMEMRYIPLKVALFYLLNPYTILSCVAKSTCAINNTLIAFFILTTIKGSAFLSAIFLALATYQSLYPLTLF VPGLLYLLQRQYIPVKMKSKAFWIFSWEYAMMYVGSLVVIICLSFFLLSSWDFIPAVYGFILSVPDLTPNIGLFWYFFAEMFEHFSLFFV CVFQINVFFYTIPLAIKLKEHPIFFMFIQIAVIAIFKSYPTVGDVALYMAFFPVWNHLYRFLRNIFVLTCIIIVCSLLFPVLWHLWIYAG SANSNFFYAITLTFNVGQETKINCVRLATKAPMGSAQVTPGTPLCLLTTGASTQNSNTVEPEKQVDNTVKMAGVIAGLLMFIIILLGVML TIKRRKLAKKQKETQSGAQREMGPVASADKPTTKLSASRNDEGFSSSSQDVNGFTDGSRGELSQPTLTIQTHPYRTCDPVEMSYPRDQFQ PAIRVADLLQHITQMKRGQGYGFKEEYEALPEGQTASWDTAKEDENRNKNRYGNIISYDHSRVRLLVLDGDPHSDYINANYIDGYHRPRH YIATQGPMQETVKDFWRMIWQENSASIVMVTNLVEVGRVKCVRYWPDDTEVYGDIKVTLIETEPLAEYVIRTFTVQKKGYHEIRELRLFH FTSWPDHGVPCYATGLLGFVRQVKFLNPPEAGPIVVHCSAGAGRTGCFIAIDTMLDMAENEGVVDIFNCVRELRAQRVNLVQTEEQYVFV HDAILEACLCGNTAIPVCEFRSLYYNISRLDPQTNSSQIKDEFQTLNIVTPRVRPEDCSIGLLPRNHDKNRSMDVLPLDRCLPFLISVDG ESSNYINAALMDSHKQPAAFVVTQHPLPNTVADFWRLVFDYNCSSVVMLNEMDTAQFCMQYWPEKTSGCYGPIQVEFVSADIDEDIIHRI FRICNMARPQDGYRIVQHLQYIGWPAYRDTPPSKRSLLKVVRRLEKWQEQYDGREGRTVVHCLNGGGRSGTFCAICSVCEMIQQQNIIDV -------------------------------------------------------------- >65312_65312_2_PIGU-PTPRT_PIGU_chr20_33162908_ENST00000374820_PTPRT_chr20_40911165_ENST00000373184_length(amino acids)=1116AA_BP=377 MAAPLVLVLVVAVTVRAALFRSSLAEFISERVEVVSPLSSWKRVVEGLSLLDLGVSPYSGAVFHEITDALTAIALYFAIQDFNKVVFKKQ KLLLELDQYAPDVAELIRTPMEMRYIPLKVALFYLLNPYTILSCVAKSTCAINNTLIAFFILTTIKGSAFLSAIFLALATYQSLYPLTLF VPGLLYLLQRQYIPVKMKSKAFWIFSWEYAMMYVGSLVVIICLSFFLLSSWDFIPAVYGFILSVPDLTPNIGLFWYFFAEMFEHFSLFFV CVFQINVFFYTIPLAIKLKEHPIFFMFIQIAVIAIFKSYPTVGDVALYMAFFPVWNHLYRFLRNIFVLTCIIIVCSLLFPVLWHLWIYAG SANSNFFYAITLTFNVGQETKINCVRLATKGASTQNSNTVEPEKQVDNTVKMAGVIAGLLMFIIILLGVMLTIKRRKLAKKQKETQSGAQ REMGPVASADKPTTKLSASRNDEGFSSSSQDVNGFTDGSRGELSQPTLTIQTHPYRTCDPVEMSYPRDQFQPAIRVADLLQHITQMKRGQ GYGFKEEYEALPEGQTASWDTAKEDENRNKNRYGNIISYDHSRVRLLVLDGDPHSDYINANYIDGYHRPRHYIATQGPMQETVKDFWRMI WQENSASIVMVTNLVEVGRHPAEHTVGNATLGRAASPGMVKCVRYWPDDTEVYGDIKVTLIETEPLAEYVIRTFTVQKKGYHEIRELRLF HFTSWPDHGVPCYATGLLGFVRQVKFLNPPEAGPIVVHCSAGAGRTGCFIAIDTMLDMAENEGVVDIFNCVRELRAQRVNLVQTEEQYVF VHDAILEACLCGNTAIPVCEFRSLYYNISRLDPQTNSSQIKDEFQTLNIVTPRVRPEDCSIGLLPRNHDKNRSMDVLPLDRCLPFLISVD GESSNYINAALMDSHKQPAAFVVTQHPLPNTVADFWRLVFDYNCSSVVMLNEMDTAQFCMQYWPEKTSGCYGPIQVEFVSADIDEDIIHR IFRICNMARPQDGYRIVQHLQYIGWPAYRDTPPSKRSLLKVVRRLEKWQEQYDGREGRTVVHCLNGGGRSGTFCAICSVCEMIQQQNIID -------------------------------------------------------------- >65312_65312_3_PIGU-PTPRT_PIGU_chr20_33162908_ENST00000374820_PTPRT_chr20_40911165_ENST00000373187_length(amino acids)=1106AA_BP=377 MAAPLVLVLVVAVTVRAALFRSSLAEFISERVEVVSPLSSWKRVVEGLSLLDLGVSPYSGAVFHEITDALTAIALYFAIQDFNKVVFKKQ KLLLELDQYAPDVAELIRTPMEMRYIPLKVALFYLLNPYTILSCVAKSTCAINNTLIAFFILTTIKGSAFLSAIFLALATYQSLYPLTLF VPGLLYLLQRQYIPVKMKSKAFWIFSWEYAMMYVGSLVVIICLSFFLLSSWDFIPAVYGFILSVPDLTPNIGLFWYFFAEMFEHFSLFFV CVFQINVFFYTIPLAIKLKEHPIFFMFIQIAVIAIFKSYPTVGDVALYMAFFPVWNHLYRFLRNIFVLTCIIIVCSLLFPVLWHLWIYAG SANSNFFYAITLTFNVGQETKINCVRLATKGASTQNSNTVEPEKQVDNTVKMAGVIAGLLMFIIILLGVMLTIKRRRNAYSYSYYLKLAK KQKETQSGAQREMGPVASADKPTTKLSASRNDEGFSSSSQDVNGFTDGSRGELSQPTLTIQTHPYRTCDPVEMSYPRDQFQPAIRVADLL QHITQMKRGQGYGFKEEYEALPEGQTASWDTAKEDENRNKNRYGNIISYDHSRVRLLVLDGDPHSDYINANYIDGYHRPRHYIATQGPMQ ETVKDFWRMIWQENSASIVMVTNLVEVGRVKCVRYWPDDTEVYGDIKVTLIETEPLAEYVIRTFTVQKKGYHEIRELRLFHFTSWPDHGV PCYATGLLGFVRQVKFLNPPEAGPIVVHCSAGAGRTGCFIAIDTMLDMAENEGVVDIFNCVRELRAQRVNLVQTEEQYVFVHDAILEACL CGNTAIPVCEFRSLYYNISRLDPQTNSSQIKDEFQTLNIVTPRVRPEDCSIGLLPRNHDKNRSMDVLPLDRCLPFLISVDGESSNYINAA LMDSHKQPAAFVVTQHPLPNTVADFWRLVFDYNCSSVVMLNEMDTAQFCMQYWPEKTSGCYGPIQVEFVSADIDEDIIHRIFRICNMARP QDGYRIVQHLQYIGWPAYRDTPPSKRSLLKVVRRLEKWQEQYDGREGRTVVHCLNGGGRSGTFCAICSVCEMIQQQNIIDVFHIVKTLRN -------------------------------------------------------------- >65312_65312_4_PIGU-PTPRT_PIGU_chr20_33162908_ENST00000374820_PTPRT_chr20_40911165_ENST00000373190_length(amino acids)=1105AA_BP=377 MAAPLVLVLVVAVTVRAALFRSSLAEFISERVEVVSPLSSWKRVVEGLSLLDLGVSPYSGAVFHEITDALTAIALYFAIQDFNKVVFKKQ KLLLELDQYAPDVAELIRTPMEMRYIPLKVALFYLLNPYTILSCVAKSTCAINNTLIAFFILTTIKGSAFLSAIFLALATYQSLYPLTLF VPGLLYLLQRQYIPVKMKSKAFWIFSWEYAMMYVGSLVVIICLSFFLLSSWDFIPAVYGFILSVPDLTPNIGLFWYFFAEMFEHFSLFFV CVFQINVFFYTIPLAIKLKEHPIFFMFIQIAVIAIFKSYPTVGDVALYMAFFPVWNHLYRFLRNIFVLTCIIIVCSLLFPVLWHLWIYAG SANSNFFYAITLTFNVGQETKINCVRLATKGASTQNSNTVEPEKQVDNTVKMAGVIAGLLMFIIILLGVMLTIKRRRNAYSYSYYLKLAK KQKETQSGAQREMGPVASADKPTTKLSASRNDEGFSSSSQDVNGFNGSRGELSQPTLTIQTHPYRTCDPVEMSYPRDQFQPAIRVADLLQ HITQMKRGQGYGFKEEYEALPEGQTASWDTAKEDENRNKNRYGNIISYDHSRVRLLVLDGDPHSDYINANYIDGYHRPRHYIATQGPMQE TVKDFWRMIWQENSASIVMVTNLVEVGRVKCVRYWPDDTEVYGDIKVTLIETEPLAEYVIRTFTVQKKGYHEIRELRLFHFTSWPDHGVP CYATGLLGFVRQVKFLNPPEAGPIVVHCSAGAGRTGCFIAIDTMLDMAENEGVVDIFNCVRELRAQRVNLVQTEEQYVFVHDAILEACLC GNTAIPVCEFRSLYYNISRLDPQTNSSQIKDEFQTLNIVTPRVRPEDCSIGLLPRNHDKNRSMDVLPLDRCLPFLISVDGESSNYINAAL MDSHKQPAAFVVTQHPLPNTVADFWRLVFDYNCSSVVMLNEMDTAQFCMQYWPEKTSGCYGPIQVEFVSADIDEDIIHRIFRICNMARPQ DGYRIVQHLQYIGWPAYRDTPPSKRSLLKVVRRLEKWQEQYDGREGRTVVHCLNGGGRSGTFCAICSVCEMIQQQNIIDVFHIVKTLRNN -------------------------------------------------------------- >65312_65312_5_PIGU-PTPRT_PIGU_chr20_33162908_ENST00000374820_PTPRT_chr20_40911165_ENST00000373193_length(amino acids)=1109AA_BP=377 MAAPLVLVLVVAVTVRAALFRSSLAEFISERVEVVSPLSSWKRVVEGLSLLDLGVSPYSGAVFHEITDALTAIALYFAIQDFNKVVFKKQ KLLLELDQYAPDVAELIRTPMEMRYIPLKVALFYLLNPYTILSCVAKSTCAINNTLIAFFILTTIKGSAFLSAIFLALATYQSLYPLTLF VPGLLYLLQRQYIPVKMKSKAFWIFSWEYAMMYVGSLVVIICLSFFLLSSWDFIPAVYGFILSVPDLTPNIGLFWYFFAEMFEHFSLFFV CVFQINVFFYTIPLAIKLKEHPIFFMFIQIAVIAIFKSYPTVGDVALYMAFFPVWNHLYRFLRNIFVLTCIIIVCSLLFPVLWHLWIYAG SANSNFFYAITLTFNVGQETKINCVRLATKGASTQNSNTVEPEKQVDNTVKMAGVIAGLLMFIIILLGVMLTIKRRRNAYSYSYYLSQRK LAKKQKETQSGAQREMGPVASADKPTTKLSASRNDEGFSSSSQDVNGFTDGSRGELSQPTLTIQTHPYRTCDPVEMSYPRDQFQPAIRVA DLLQHITQMKRGQGYGFKEEYEALPEGQTASWDTAKEDENRNKNRYGNIISYDHSRVRLLVLDGDPHSDYINANYIDGYHRPRHYIATQG PMQETVKDFWRMIWQENSASIVMVTNLVEVGRVKCVRYWPDDTEVYGDIKVTLIETEPLAEYVIRTFTVQKKGYHEIRELRLFHFTSWPD HGVPCYATGLLGFVRQVKFLNPPEAGPIVVHCSAGAGRTGCFIAIDTMLDMAENEGVVDIFNCVRELRAQRVNLVQTEEQYVFVHDAILE ACLCGNTAIPVCEFRSLYYNISRLDPQTNSSQIKDEFQTLNIVTPRVRPEDCSIGLLPRNHDKNRSMDVLPLDRCLPFLISVDGESSNYI NAALMDSHKQPAAFVVTQHPLPNTVADFWRLVFDYNCSSVVMLNEMDTAQFCMQYWPEKTSGCYGPIQVEFVSADIDEDIIHRIFRICNM ARPQDGYRIVQHLQYIGWPAYRDTPPSKRSLLKVVRRLEKWQEQYDGREGRTVVHCLNGGGRSGTFCAICSVCEMIQQQNIIDVFHIVKT -------------------------------------------------------------- >65312_65312_6_PIGU-PTPRT_PIGU_chr20_33162908_ENST00000374820_PTPRT_chr20_40911165_ENST00000373198_length(amino acids)=1125AA_BP=377 MAAPLVLVLVVAVTVRAALFRSSLAEFISERVEVVSPLSSWKRVVEGLSLLDLGVSPYSGAVFHEITDALTAIALYFAIQDFNKVVFKKQ KLLLELDQYAPDVAELIRTPMEMRYIPLKVALFYLLNPYTILSCVAKSTCAINNTLIAFFILTTIKGSAFLSAIFLALATYQSLYPLTLF VPGLLYLLQRQYIPVKMKSKAFWIFSWEYAMMYVGSLVVIICLSFFLLSSWDFIPAVYGFILSVPDLTPNIGLFWYFFAEMFEHFSLFFV CVFQINVFFYTIPLAIKLKEHPIFFMFIQIAVIAIFKSYPTVGDVALYMAFFPVWNHLYRFLRNIFVLTCIIIVCSLLFPVLWHLWIYAG SANSNFFYAITLTFNVGQETKINCVRLATKAPMGSAQVTPGTPLCLLTTGASTQNSNTVEPEKQVDNTVKMAGVIAGLLMFIIILLGVML TIKRRRNAYSYSYYLKLAKKQKETQSGAQREMGPVASADKPTTKLSASRNDEGFSSSSQDVNGFTDGSRGELSQPTLTIQTHPYRTCDPV EMSYPRDQFQPAIRVADLLQHITQMKRGQGYGFKEEYEALPEGQTASWDTAKEDENRNKNRYGNIISYDHSRVRLLVLDGDPHSDYINAN YIDGYHRPRHYIATQGPMQETVKDFWRMIWQENSASIVMVTNLVEVGRVKCVRYWPDDTEVYGDIKVTLIETEPLAEYVIRTFTVQKKGY HEIRELRLFHFTSWPDHGVPCYATGLLGFVRQVKFLNPPEAGPIVVHCSAGAGRTGCFIAIDTMLDMAENEGVVDIFNCVRELRAQRVNL VQTEEQYVFVHDAILEACLCGNTAIPVCEFRSLYYNISRLDPQTNSSQIKDEFQTLNIVTPRVRPEDCSIGLLPRNHDKNRSMDVLPLDR CLPFLISVDGESSNYINAALMDSHKQPAAFVVTQHPLPNTVADFWRLVFDYNCSSVVMLNEMDTAQFCMQYWPEKTSGCYGPIQVEFVSA DIDEDIIHRIFRICNMARPQDGYRIVQHLQYIGWPAYRDTPPSKRSLLKVVRRLEKWQEQYDGREGRTVVHCLNGGGRSGTFCAICSVCE -------------------------------------------------------------- >65312_65312_7_PIGU-PTPRT_PIGU_chr20_33162908_ENST00000374820_PTPRT_chr20_40911165_ENST00000373201_length(amino acids)=1096AA_BP=377 MAAPLVLVLVVAVTVRAALFRSSLAEFISERVEVVSPLSSWKRVVEGLSLLDLGVSPYSGAVFHEITDALTAIALYFAIQDFNKVVFKKQ KLLLELDQYAPDVAELIRTPMEMRYIPLKVALFYLLNPYTILSCVAKSTCAINNTLIAFFILTTIKGSAFLSAIFLALATYQSLYPLTLF VPGLLYLLQRQYIPVKMKSKAFWIFSWEYAMMYVGSLVVIICLSFFLLSSWDFIPAVYGFILSVPDLTPNIGLFWYFFAEMFEHFSLFFV CVFQINVFFYTIPLAIKLKEHPIFFMFIQIAVIAIFKSYPTVGDVALYMAFFPVWNHLYRFLRNIFVLTCIIIVCSLLFPVLWHLWIYAG SANSNFFYAITLTFNVGQETKINCVRLATKGASTQNSNTVEPEKQVDNTVKMAGVIAGLLMFIIILLGVMLTIKRRKLAKKQKETQSGAQ REMGPVASADKPTTKLSASRNDEGFSSSSQDVNGFTDGSRGELSQPTLTIQTHPYRTCDPVEMSYPRDQFQPAIRVADLLQHITQMKRGQ GYGFKEEYEALPEGQTASWDTAKEDENRNKNRYGNIISYDHSRVRLLVLDGDPHSDYINANYIDGYHRPRHYIATQGPMQETVKDFWRMI WQENSASIVMVTNLVEVGRVKCVRYWPDDTEVYGDIKVTLIETEPLAEYVIRTFTVQKKGYHEIRELRLFHFTSWPDHGVPCYATGLLGF VRQVKFLNPPEAGPIVVHCSAGAGRTGCFIAIDTMLDMAENEGVVDIFNCVRELRAQRVNLVQTEEQYVFVHDAILEACLCGNTAIPVCE FRSLYYNISRLDPQTNSSQIKDEFQTLNIVTPRVRPEDCSIGLLPRNHDKNRSMDVLPLDRCLPFLISVDGESSNYINAALMDSHKQPAA FVVTQHPLPNTVADFWRLVFDYNCSSVVMLNEMDTAQFCMQYWPEKTSGCYGPIQVEFVSADIDEDIIHRIFRICNMARPQDGYRIVQHL QYIGWPAYRDTPPSKRSLLKVVRRLEKWQEQYDGREGRTVVHCLNGGGRSGTFCAICSVCEMIQQQNIIDVFHIVKTLRNNKSNMVETLE -------------------------------------------------------------- |
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Fusion Protein Functional Features |
![]() Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr20:33162908/chr20:40911165) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
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Hgene | Tgene |
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FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes. | FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes. |
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- Retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Hgene | PIGU | chr20:33162908 | chr20:40911165 | ENST00000374820 | - | 10 | 11 | 269_289 | 378.0 | 416.0 | Region | Note=May be involved in recognition of long-chain fatty acids in GPI |
Hgene | PIGU | chr20:33162908 | chr20:40911165 | ENST00000374820 | - | 10 | 11 | 166_186 | 378.0 | 416.0 | Transmembrane | Helical |
Hgene | PIGU | chr20:33162908 | chr20:40911165 | ENST00000374820 | - | 10 | 11 | 188_208 | 378.0 | 416.0 | Transmembrane | Helical |
Hgene | PIGU | chr20:33162908 | chr20:40911165 | ENST00000374820 | - | 10 | 11 | 237_257 | 378.0 | 416.0 | Transmembrane | Helical |
Hgene | PIGU | chr20:33162908 | chr20:40911165 | ENST00000374820 | - | 10 | 11 | 259_279 | 378.0 | 416.0 | Transmembrane | Helical |
Hgene | PIGU | chr20:33162908 | chr20:40911165 | ENST00000374820 | - | 10 | 11 | 286_306 | 378.0 | 416.0 | Transmembrane | Helical |
Hgene | PIGU | chr20:33162908 | chr20:40911165 | ENST00000374820 | - | 10 | 11 | 313_333 | 378.0 | 416.0 | Transmembrane | Helical |
Hgene | PIGU | chr20:33162908 | chr20:40911165 | ENST00000374820 | - | 10 | 11 | 355_375 | 378.0 | 416.0 | Transmembrane | Helical |
Hgene | PIGU | chr20:33162908 | chr20:40911165 | ENST00000374820 | - | 10 | 11 | 66_86 | 378.0 | 416.0 | Transmembrane | Helical |
Tgene | PTPRT | chr20:33162908 | chr20:40911165 | ENST00000373187 | 11 | 31 | 1175_1437 | 713.0 | 1442.0 | Domain | Tyrosine-protein phosphatase 2 | |
Tgene | PTPRT | chr20:33162908 | chr20:40911165 | ENST00000373187 | 11 | 31 | 889_1143 | 713.0 | 1442.0 | Domain | Tyrosine-protein phosphatase 1 | |
Tgene | PTPRT | chr20:33162908 | chr20:40911165 | ENST00000373198 | 11 | 32 | 1175_1437 | 713.0 | 1461.0 | Domain | Tyrosine-protein phosphatase 2 | |
Tgene | PTPRT | chr20:33162908 | chr20:40911165 | ENST00000373198 | 11 | 32 | 889_1143 | 713.0 | 1461.0 | Domain | Tyrosine-protein phosphatase 1 | |
Tgene | PTPRT | chr20:33162908 | chr20:40911165 | ENST00000373187 | 11 | 31 | 1084_1090 | 713.0 | 1442.0 | Region | Substrate binding | |
Tgene | PTPRT | chr20:33162908 | chr20:40911165 | ENST00000373198 | 11 | 32 | 1084_1090 | 713.0 | 1461.0 | Region | Substrate binding | |
Tgene | PTPRT | chr20:33162908 | chr20:40911165 | ENST00000373187 | 11 | 31 | 769_1441 | 713.0 | 1442.0 | Topological domain | Cytoplasmic | |
Tgene | PTPRT | chr20:33162908 | chr20:40911165 | ENST00000373198 | 11 | 32 | 769_1441 | 713.0 | 1461.0 | Topological domain | Cytoplasmic | |
Tgene | PTPRT | chr20:33162908 | chr20:40911165 | ENST00000373187 | 11 | 31 | 748_768 | 713.0 | 1442.0 | Transmembrane | Helical | |
Tgene | PTPRT | chr20:33162908 | chr20:40911165 | ENST00000373198 | 11 | 32 | 748_768 | 713.0 | 1461.0 | Transmembrane | Helical |
- Not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Hgene | PIGU | chr20:33162908 | chr20:40911165 | ENST00000374820 | - | 10 | 11 | 386_406 | 378.0 | 416.0 | Transmembrane | Helical |
Tgene | PTPRT | chr20:33162908 | chr20:40911165 | ENST00000373187 | 11 | 31 | 193_284 | 713.0 | 1442.0 | Domain | Note=Ig-like C2-type | |
Tgene | PTPRT | chr20:33162908 | chr20:40911165 | ENST00000373187 | 11 | 31 | 291_384 | 713.0 | 1442.0 | Domain | Fibronectin type-III 1 | |
Tgene | PTPRT | chr20:33162908 | chr20:40911165 | ENST00000373187 | 11 | 31 | 30_191 | 713.0 | 1442.0 | Domain | MAM | |
Tgene | PTPRT | chr20:33162908 | chr20:40911165 | ENST00000373187 | 11 | 31 | 389_483 | 713.0 | 1442.0 | Domain | Fibronectin type-III 2 | |
Tgene | PTPRT | chr20:33162908 | chr20:40911165 | ENST00000373187 | 11 | 31 | 484_590 | 713.0 | 1442.0 | Domain | Fibronectin type-III 3 | |
Tgene | PTPRT | chr20:33162908 | chr20:40911165 | ENST00000373187 | 11 | 31 | 591_726 | 713.0 | 1442.0 | Domain | Fibronectin type-III 4 | |
Tgene | PTPRT | chr20:33162908 | chr20:40911165 | ENST00000373198 | 11 | 32 | 193_284 | 713.0 | 1461.0 | Domain | Note=Ig-like C2-type | |
Tgene | PTPRT | chr20:33162908 | chr20:40911165 | ENST00000373198 | 11 | 32 | 291_384 | 713.0 | 1461.0 | Domain | Fibronectin type-III 1 | |
Tgene | PTPRT | chr20:33162908 | chr20:40911165 | ENST00000373198 | 11 | 32 | 30_191 | 713.0 | 1461.0 | Domain | MAM | |
Tgene | PTPRT | chr20:33162908 | chr20:40911165 | ENST00000373198 | 11 | 32 | 389_483 | 713.0 | 1461.0 | Domain | Fibronectin type-III 2 | |
Tgene | PTPRT | chr20:33162908 | chr20:40911165 | ENST00000373198 | 11 | 32 | 484_590 | 713.0 | 1461.0 | Domain | Fibronectin type-III 3 | |
Tgene | PTPRT | chr20:33162908 | chr20:40911165 | ENST00000373198 | 11 | 32 | 591_726 | 713.0 | 1461.0 | Domain | Fibronectin type-III 4 | |
Tgene | PTPRT | chr20:33162908 | chr20:40911165 | ENST00000373187 | 11 | 31 | 26_747 | 713.0 | 1442.0 | Topological domain | Extracellular | |
Tgene | PTPRT | chr20:33162908 | chr20:40911165 | ENST00000373198 | 11 | 32 | 26_747 | 713.0 | 1461.0 | Topological domain | Extracellular |
Top |
Fusion Protein-Protein Interaction |
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Gene | PPI interactors |
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Gene | STRING network |
PIGU | |
PTPRT |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
Top |
Related Drugs to PIGU-PTPRT |
![]() (Manual curation of PubMed, 04-30-2022 + MyCancerGenome) |
Hgene | Tgene | Drug | Source | PMID |
Top |
Related Diseases to PIGU-PTPRT |
![]() (Manual curation of PubMed, 04-30-2022 + MyCancerGenome) |
Hgene | Tgene | Disease | Source | PMID |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |