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Fusion Protein:ARL13B-DLG1 |
Fusion Protein Summary |
 Fusion gene summary |
| Fusion partner gene information | Fusion gene name: ARL13B-DLG1 | FusionPDB ID: 6547 | FusionGDB2.0 ID: 6547 | Hgene | Tgene | Gene symbol | ARL13B | DLG1 | Gene ID | 200894 | 1739 |
| Gene name | ADP ribosylation factor like GTPase 13B | discs large MAGUK scaffold protein 1 | |
| Synonyms | ARL2L1|JBTS8 | DLGH1|SAP-97|SAP97|hdlg | |
| Cytomap | 3q11.1-q11.2 | 3q29 | |
| Type of gene | protein-coding | protein-coding | |
| Description | ADP-ribosylation factor-like protein 13BADP-ribosylation factor-like 13BADP-ribosylation factor-like 2-like 1ARL2-like protein 1 | disks large homolog 1dJ1061C18.1.1discs large homolog 1, scribble cell polarity complex componentpresynaptic protein SAP97synapse-associated protein 97 | |
| Modification date | 20200313 | 20200327 | |
| UniProtAcc | Q3SXY8 | Q12959 | |
| Ensembl transtripts involved in fusion gene | ENST ids | ENST00000394222, ENST00000471138, ENST00000535334, ENST00000303097, ENST00000486562, ENST00000539730, | ENST00000485409, ENST00000314062, ENST00000346964, ENST00000357674, ENST00000392382, ENST00000419354, ENST00000422288, ENST00000443183, ENST00000448528, ENST00000450955, ENST00000452595, |
| Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0) | * DoF score | 5 X 3 X 5=75 | 14 X 15 X 6=1260 |
| # samples | 5 | 16 | |
| ** MAII score | log2(5/75*10)=-0.584962500721156 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(16/1260*10)=-2.97727992349992 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context (manual curation of fusion genes in FusionPDB) | PubMed: ARL13B [Title/Abstract] AND DLG1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0) | ARL13B(93722752)-DLG1(196812627), # samples:1 | ||
| Anticipated loss of major functional domain due to fusion event. | ARL13B-DLG1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. ARL13B-DLG1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. ARL13B-DLG1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. ARL13B-DLG1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | DLG1 | GO:0001935 | endothelial cell proliferation | 14699157 |
| Tgene | DLG1 | GO:0007015 | actin filament organization | 14699157 |
| Tgene | DLG1 | GO:0030866 | cortical actin cytoskeleton organization | 14699157 |
| Tgene | DLG1 | GO:0042391 | regulation of membrane potential | 12970345 |
| Tgene | DLG1 | GO:0043268 | positive regulation of potassium ion transport | 12970345 |
| Tgene | DLG1 | GO:0070830 | bicellular tight junction assembly | 17332497 |
| Tgene | DLG1 | GO:0098609 | cell-cell adhesion | 14699157 |
| Tgene | DLG1 | GO:1902473 | regulation of protein localization to synapse | 23676497 |
| Tgene | DLG1 | GO:1903078 | positive regulation of protein localization to plasma membrane | 12970345 |
| Fusion gene breakpoints across ARL13B (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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| Fusion gene breakpoints across DLG1 (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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Fusion Gene Sample Information |
| Fusion gene information from FusionGDB2.0. |
| Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChimerDB4 | GBM | TCGA-06-A5U1-01A | ARL13B | chr3 | 93722752 | + | DLG1 | chr3 | 196812627 | - |
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Fusion ORF Analysis |
| Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
| ENST00000535334 | ARL13B | chr3 | 93722752 | + | ENST00000357674 | DLG1 | chr3 | 196812627 | - | 3678 | 594 | 337 | 1614 | 425 |
| ENST00000535334 | ARL13B | chr3 | 93722752 | + | ENST00000314062 | DLG1 | chr3 | 196812627 | - | 3612 | 594 | 337 | 1548 | 403 |
| ENST00000535334 | ARL13B | chr3 | 93722752 | + | ENST00000346964 | DLG1 | chr3 | 196812627 | - | 3678 | 594 | 337 | 1614 | 425 |
| ENST00000535334 | ARL13B | chr3 | 93722752 | + | ENST00000419354 | DLG1 | chr3 | 196812627 | - | 2541 | 594 | 337 | 1548 | 403 |
| ENST00000535334 | ARL13B | chr3 | 93722752 | + | ENST00000452595 | DLG1 | chr3 | 196812627 | - | 1912 | 594 | 337 | 1548 | 403 |
| ENST00000535334 | ARL13B | chr3 | 93722752 | + | ENST00000422288 | DLG1 | chr3 | 196812627 | - | 1841 | 594 | 337 | 1548 | 403 |
| ENST00000535334 | ARL13B | chr3 | 93722752 | + | ENST00000448528 | DLG1 | chr3 | 196812627 | - | 1621 | 594 | 337 | 1548 | 403 |
| ENST00000535334 | ARL13B | chr3 | 93722752 | + | ENST00000443183 | DLG1 | chr3 | 196812627 | - | 1648 | 594 | 337 | 1584 | 415 |
| ENST00000535334 | ARL13B | chr3 | 93722752 | + | ENST00000450955 | DLG1 | chr3 | 196812627 | - | 1615 | 594 | 337 | 1614 | 426 |
| ENST00000535334 | ARL13B | chr3 | 93722752 | + | ENST00000392382 | DLG1 | chr3 | 196812627 | - | 1549 | 594 | 337 | 1548 | 404 |
| ENST00000394222 | ARL13B | chr3 | 93722752 | + | ENST00000357674 | DLG1 | chr3 | 196812627 | - | 3739 | 655 | 275 | 1675 | 466 |
| ENST00000394222 | ARL13B | chr3 | 93722752 | + | ENST00000314062 | DLG1 | chr3 | 196812627 | - | 3673 | 655 | 275 | 1609 | 444 |
| ENST00000394222 | ARL13B | chr3 | 93722752 | + | ENST00000346964 | DLG1 | chr3 | 196812627 | - | 3739 | 655 | 275 | 1675 | 466 |
| ENST00000394222 | ARL13B | chr3 | 93722752 | + | ENST00000419354 | DLG1 | chr3 | 196812627 | - | 2602 | 655 | 275 | 1609 | 444 |
| ENST00000394222 | ARL13B | chr3 | 93722752 | + | ENST00000452595 | DLG1 | chr3 | 196812627 | - | 1973 | 655 | 275 | 1609 | 444 |
| ENST00000394222 | ARL13B | chr3 | 93722752 | + | ENST00000422288 | DLG1 | chr3 | 196812627 | - | 1902 | 655 | 275 | 1609 | 444 |
| ENST00000394222 | ARL13B | chr3 | 93722752 | + | ENST00000448528 | DLG1 | chr3 | 196812627 | - | 1682 | 655 | 275 | 1609 | 444 |
| ENST00000394222 | ARL13B | chr3 | 93722752 | + | ENST00000443183 | DLG1 | chr3 | 196812627 | - | 1709 | 655 | 275 | 1645 | 456 |
| ENST00000394222 | ARL13B | chr3 | 93722752 | + | ENST00000450955 | DLG1 | chr3 | 196812627 | - | 1676 | 655 | 275 | 1675 | 467 |
| ENST00000394222 | ARL13B | chr3 | 93722752 | + | ENST00000392382 | DLG1 | chr3 | 196812627 | - | 1610 | 655 | 275 | 1609 | 445 |
| ENST00000471138 | ARL13B | chr3 | 93722752 | + | ENST00000357674 | DLG1 | chr3 | 196812627 | - | 3733 | 649 | 269 | 1669 | 466 |
| ENST00000471138 | ARL13B | chr3 | 93722752 | + | ENST00000314062 | DLG1 | chr3 | 196812627 | - | 3667 | 649 | 269 | 1603 | 444 |
| ENST00000471138 | ARL13B | chr3 | 93722752 | + | ENST00000346964 | DLG1 | chr3 | 196812627 | - | 3733 | 649 | 269 | 1669 | 466 |
| ENST00000471138 | ARL13B | chr3 | 93722752 | + | ENST00000419354 | DLG1 | chr3 | 196812627 | - | 2596 | 649 | 269 | 1603 | 444 |
| ENST00000471138 | ARL13B | chr3 | 93722752 | + | ENST00000452595 | DLG1 | chr3 | 196812627 | - | 1967 | 649 | 269 | 1603 | 444 |
| ENST00000471138 | ARL13B | chr3 | 93722752 | + | ENST00000422288 | DLG1 | chr3 | 196812627 | - | 1896 | 649 | 269 | 1603 | 444 |
| ENST00000471138 | ARL13B | chr3 | 93722752 | + | ENST00000448528 | DLG1 | chr3 | 196812627 | - | 1676 | 649 | 269 | 1603 | 444 |
| ENST00000471138 | ARL13B | chr3 | 93722752 | + | ENST00000443183 | DLG1 | chr3 | 196812627 | - | 1703 | 649 | 269 | 1639 | 456 |
| ENST00000471138 | ARL13B | chr3 | 93722752 | + | ENST00000450955 | DLG1 | chr3 | 196812627 | - | 1670 | 649 | 269 | 1669 | 467 |
| ENST00000471138 | ARL13B | chr3 | 93722752 | + | ENST00000392382 | DLG1 | chr3 | 196812627 | - | 1604 | 649 | 269 | 1603 | 445 |
| DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
| ENST00000535334 | ENST00000357674 | ARL13B | chr3 | 93722752 | + | DLG1 | chr3 | 196812627 | - | 8.40E-05 | 0.9999161 |
| ENST00000535334 | ENST00000314062 | ARL13B | chr3 | 93722752 | + | DLG1 | chr3 | 196812627 | - | 0.000180925 | 0.9998191 |
| ENST00000535334 | ENST00000346964 | ARL13B | chr3 | 93722752 | + | DLG1 | chr3 | 196812627 | - | 8.40E-05 | 0.9999161 |
| ENST00000535334 | ENST00000419354 | ARL13B | chr3 | 93722752 | + | DLG1 | chr3 | 196812627 | - | 0.000230047 | 0.99977 |
| ENST00000535334 | ENST00000452595 | ARL13B | chr3 | 93722752 | + | DLG1 | chr3 | 196812627 | - | 0.000313423 | 0.9996866 |
| ENST00000535334 | ENST00000422288 | ARL13B | chr3 | 93722752 | + | DLG1 | chr3 | 196812627 | - | 0.000338694 | 0.9996613 |
| ENST00000535334 | ENST00000448528 | ARL13B | chr3 | 93722752 | + | DLG1 | chr3 | 196812627 | - | 0.000385785 | 0.99961424 |
| ENST00000535334 | ENST00000443183 | ARL13B | chr3 | 93722752 | + | DLG1 | chr3 | 196812627 | - | 0.000329554 | 0.9996705 |
| ENST00000535334 | ENST00000450955 | ARL13B | chr3 | 93722752 | + | DLG1 | chr3 | 196812627 | - | 0.000262311 | 0.9997377 |
| ENST00000535334 | ENST00000392382 | ARL13B | chr3 | 93722752 | + | DLG1 | chr3 | 196812627 | - | 0.000476817 | 0.99952316 |
| ENST00000394222 | ENST00000357674 | ARL13B | chr3 | 93722752 | + | DLG1 | chr3 | 196812627 | - | 0.000131233 | 0.99986875 |
| ENST00000394222 | ENST00000314062 | ARL13B | chr3 | 93722752 | + | DLG1 | chr3 | 196812627 | - | 9.70E-05 | 0.99990296 |
| ENST00000394222 | ENST00000346964 | ARL13B | chr3 | 93722752 | + | DLG1 | chr3 | 196812627 | - | 0.000131233 | 0.99986875 |
| ENST00000394222 | ENST00000419354 | ARL13B | chr3 | 93722752 | + | DLG1 | chr3 | 196812627 | - | 0.00012738 | 0.99987257 |
| ENST00000394222 | ENST00000452595 | ARL13B | chr3 | 93722752 | + | DLG1 | chr3 | 196812627 | - | 0.000167479 | 0.9998325 |
| ENST00000394222 | ENST00000422288 | ARL13B | chr3 | 93722752 | + | DLG1 | chr3 | 196812627 | - | 0.000184048 | 0.999816 |
| ENST00000394222 | ENST00000448528 | ARL13B | chr3 | 93722752 | + | DLG1 | chr3 | 196812627 | - | 0.00021929 | 0.9997807 |
| ENST00000394222 | ENST00000443183 | ARL13B | chr3 | 93722752 | + | DLG1 | chr3 | 196812627 | - | 0.000314848 | 0.99968517 |
| ENST00000394222 | ENST00000450955 | ARL13B | chr3 | 93722752 | + | DLG1 | chr3 | 196812627 | - | 0.000365061 | 0.999635 |
| ENST00000394222 | ENST00000392382 | ARL13B | chr3 | 93722752 | + | DLG1 | chr3 | 196812627 | - | 0.000256363 | 0.99974364 |
| ENST00000471138 | ENST00000357674 | ARL13B | chr3 | 93722752 | + | DLG1 | chr3 | 196812627 | - | 0.000131492 | 0.9998685 |
| ENST00000471138 | ENST00000314062 | ARL13B | chr3 | 93722752 | + | DLG1 | chr3 | 196812627 | - | 9.71E-05 | 0.99990284 |
| ENST00000471138 | ENST00000346964 | ARL13B | chr3 | 93722752 | + | DLG1 | chr3 | 196812627 | - | 0.000131492 | 0.9998685 |
| ENST00000471138 | ENST00000419354 | ARL13B | chr3 | 93722752 | + | DLG1 | chr3 | 196812627 | - | 0.000126998 | 0.99987304 |
| ENST00000471138 | ENST00000452595 | ARL13B | chr3 | 93722752 | + | DLG1 | chr3 | 196812627 | - | 0.000168371 | 0.99983156 |
| ENST00000471138 | ENST00000422288 | ARL13B | chr3 | 93722752 | + | DLG1 | chr3 | 196812627 | - | 0.000185324 | 0.9998147 |
| ENST00000471138 | ENST00000448528 | ARL13B | chr3 | 93722752 | + | DLG1 | chr3 | 196812627 | - | 0.000219796 | 0.99978024 |
| ENST00000471138 | ENST00000443183 | ARL13B | chr3 | 93722752 | + | DLG1 | chr3 | 196812627 | - | 0.000316296 | 0.99968374 |
| ENST00000471138 | ENST00000450955 | ARL13B | chr3 | 93722752 | + | DLG1 | chr3 | 196812627 | - | 0.0003702 | 0.99962974 |
| ENST00000471138 | ENST00000392382 | ARL13B | chr3 | 93722752 | + | DLG1 | chr3 | 196812627 | - | 0.000257304 | 0.9997427 |
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Fusion Amino Acid Sequences |
| For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
| >FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP >6547_6547_1_ARL13B-DLG1_ARL13B_chr3_93722752_ENST00000394222_DLG1_chr3_196812627_ENST00000314062_length(amino acids)=444AA_BP=127 MFSLMASCCGWFKRWREPVRKVTLLMVGLDNAGKTATAKGIQGEYPEDVAPTVGFSKINLRQGKFEVTIFDLGGGIRIRGIWKNYYAESY GVIFVVDSSDEERMEETKEAMSEMLRHPRISGKPILVALFDYDKTKDSGLPSQGLNFKFGDILHVINASDDEWWQARQVTPDGESDEVGV IPSKRRVEKKERARLKTVKFNSKTRDKGEIPDDMGSKGLKHVTSNASDSESSYRGQEEYVLSYEPVNQQEVNYTRPVIILGPMKDRINDD LISEFPDKFGSCVPHTTRPKRDYEVDGRDYHFVTSREQMEKDIQEHKFIEAGQYNNHLYGTSVQSVREVAEKGKHCILDVSGNAIKRLQI -------------------------------------------------------------- >6547_6547_2_ARL13B-DLG1_ARL13B_chr3_93722752_ENST00000394222_DLG1_chr3_196812627_ENST00000346964_length(amino acids)=466AA_BP=127 MFSLMASCCGWFKRWREPVRKVTLLMVGLDNAGKTATAKGIQGEYPEDVAPTVGFSKINLRQGKFEVTIFDLGGGIRIRGIWKNYYAESY GVIFVVDSSDEERMEETKEAMSEMLRHPRISGKPILVALFDYDKTKDSGLPSQGLNFKFGDILHVINASDDEWWQARQVTPDGESDEVGV IPSKRRVEKKERARLKTVKFNSKTRDKGQSFNDKRKKNLFSRKFPFYKNKDQSEQETSDADQHVTSNASDSESSYRGQEEYVLSYEPVNQ QEVNYTRPVIILGPMKDRINDDLISEFPDKFGSCVPHTTRPKRDYEVDGRDYHFVTSREQMEKDIQEHKFIEAGQYNNHLYGTSVQSVRE VAEKGKHCILDVSGNAIKRLQIAQLYPISIFIKPKSMENIMEMNKRLTEEQARKTFERAMKLEQEFTEHFTAIVQGDTLEDIYNQVKQII -------------------------------------------------------------- >6547_6547_3_ARL13B-DLG1_ARL13B_chr3_93722752_ENST00000394222_DLG1_chr3_196812627_ENST00000357674_length(amino acids)=466AA_BP=127 MFSLMASCCGWFKRWREPVRKVTLLMVGLDNAGKTATAKGIQGEYPEDVAPTVGFSKINLRQGKFEVTIFDLGGGIRIRGIWKNYYAESY GVIFVVDSSDEERMEETKEAMSEMLRHPRISGKPILVALFDYDKTKDSGLPSQGLNFKFGDILHVINASDDEWWQARQVTPDGESDEVGV IPSKRRVEKKERARLKTVKFNSKTRDKGQSFNDKRKKNLFSRKFPFYKNKDQSEQETSDADQHVTSNASDSESSYRGQEEYVLSYEPVNQ QEVNYTRPVIILGPMKDRINDDLISEFPDKFGSCVPHTTRPKRDYEVDGRDYHFVTSREQMEKDIQEHKFIEAGQYNNHLYGTSVQSVRE VAEKGKHCILDVSGNAIKRLQIAQLYPISIFIKPKSMENIMEMNKRLTEEQARKTFERAMKLEQEFTEHFTAIVQGDTLEDIYNQVKQII -------------------------------------------------------------- >6547_6547_4_ARL13B-DLG1_ARL13B_chr3_93722752_ENST00000394222_DLG1_chr3_196812627_ENST00000392382_length(amino acids)=445AA_BP=127 MFSLMASCCGWFKRWREPVRKVTLLMVGLDNAGKTATAKGIQGEYPEDVAPTVGFSKINLRQGKFEVTIFDLGGGIRIRGIWKNYYAESY GVIFVVDSSDEERMEETKEAMSEMLRHPRISGKPILVALFDYDKTKDSGLPSQGLNFKFGDILHVINASDDEWWQARQVTPDGESDEVGV IPSKRRVEKKERARLKTVKFNSKTRDKGEIPDDMGSKGLKHVTSNASDSESSYRGQEEYVLSYEPVNQQEVNYTRPVIILGPMKDRINDD LISEFPDKFGSCVPHTTRPKRDYEVDGRDYHFVTSREQMEKDIQEHKFIEAGQYNNHLYGTSVQSVREVAEKGKHCILDVSGNAIKRLQI -------------------------------------------------------------- >6547_6547_5_ARL13B-DLG1_ARL13B_chr3_93722752_ENST00000394222_DLG1_chr3_196812627_ENST00000419354_length(amino acids)=444AA_BP=127 MFSLMASCCGWFKRWREPVRKVTLLMVGLDNAGKTATAKGIQGEYPEDVAPTVGFSKINLRQGKFEVTIFDLGGGIRIRGIWKNYYAESY GVIFVVDSSDEERMEETKEAMSEMLRHPRISGKPILVALFDYDKTKDSGLPSQGLNFKFGDILHVINASDDEWWQARQVTPDGESDEVGV IPSKRRVEKKERARLKTVKFNSKTRDKGEIPDDMGSKGLKHVTSNASDSESSYRGQEEYVLSYEPVNQQEVNYTRPVIILGPMKDRINDD LISEFPDKFGSCVPHTTRPKRDYEVDGRDYHFVTSREQMEKDIQEHKFIEAGQYNNHLYGTSVQSVREVAEKGKHCILDVSGNAIKRLQI -------------------------------------------------------------- >6547_6547_6_ARL13B-DLG1_ARL13B_chr3_93722752_ENST00000394222_DLG1_chr3_196812627_ENST00000422288_length(amino acids)=444AA_BP=127 MFSLMASCCGWFKRWREPVRKVTLLMVGLDNAGKTATAKGIQGEYPEDVAPTVGFSKINLRQGKFEVTIFDLGGGIRIRGIWKNYYAESY GVIFVVDSSDEERMEETKEAMSEMLRHPRISGKPILVALFDYDKTKDSGLPSQGLNFKFGDILHVINASDDEWWQARQVTPDGESDEVGV IPSKRRVEKKERARLKTVKFNSKTRDKGEIPDDMGSKGLKHVTSNASDSESSYRGQEEYVLSYEPVNQQEVNYTRPVIILGPMKDRINDD LISEFPDKFGSCVPHTTRPKRDYEVDGRDYHFVTSREQMEKDIQEHKFIEAGQYNNHLYGTSVQSVREVAEKGKHCILDVSGNAIKRLQI -------------------------------------------------------------- >6547_6547_7_ARL13B-DLG1_ARL13B_chr3_93722752_ENST00000394222_DLG1_chr3_196812627_ENST00000443183_length(amino acids)=456AA_BP=127 MFSLMASCCGWFKRWREPVRKVTLLMVGLDNAGKTATAKGIQGEYPEDVAPTVGFSKINLRQGKFEVTIFDLGGGIRIRGIWKNYYAESY GVIFVVDSSDEERMEETKEAMSEMLRHPRISGKPILVALFDYDKTKDSGLPSQGLNFKFGDILHVINASDDEWWQARQVTPDGESDEVGV IPSKRRVEKKERARLKTVKFNSKTRDKGEIPDDMGSKGLKHVTSNASDSESSYLILITDEYGCSKGGQEEYVLSYEPVNQQEVNYTRPVI ILGPMKDRINDDLISEFPDKFGSCVPHTTRPKRDYEVDGRDYHFVTSREQMEKDIQEHKFIEAGQYNNHLYGTSVQSVREVAEKGKHCIL DVSGNAIKRLQIAQLYPISIFIKPKSMENIMEMNKRLTEEQARKTFERAMKLEQEFTEHFTAIVQGDTLEDIYNQVKQIIEEQSGSYIWV -------------------------------------------------------------- >6547_6547_8_ARL13B-DLG1_ARL13B_chr3_93722752_ENST00000394222_DLG1_chr3_196812627_ENST00000448528_length(amino acids)=444AA_BP=127 MFSLMASCCGWFKRWREPVRKVTLLMVGLDNAGKTATAKGIQGEYPEDVAPTVGFSKINLRQGKFEVTIFDLGGGIRIRGIWKNYYAESY GVIFVVDSSDEERMEETKEAMSEMLRHPRISGKPILVALFDYDKTKDSGLPSQGLNFKFGDILHVINASDDEWWQARQVTPDGESDEVGV IPSKRRVEKKERARLKTVKFNSKTRDKGEIPDDMGSKGLKHVTSNASDSESSYRGQEEYVLSYEPVNQQEVNYTRPVIILGPMKDRINDD LISEFPDKFGSCVPHTTRPKRDYEVDGRDYHFVTSREQMEKDIQEHKFIEAGQYNNHLYGTSVQSVREVAEKGKHCILDVSGNAIKRLQI -------------------------------------------------------------- >6547_6547_9_ARL13B-DLG1_ARL13B_chr3_93722752_ENST00000394222_DLG1_chr3_196812627_ENST00000450955_length(amino acids)=467AA_BP=127 MFSLMASCCGWFKRWREPVRKVTLLMVGLDNAGKTATAKGIQGEYPEDVAPTVGFSKINLRQGKFEVTIFDLGGGIRIRGIWKNYYAESY GVIFVVDSSDEERMEETKEAMSEMLRHPRISGKPILVALFDYDKTKDSGLPSQGLNFKFGDILHVINASDDEWWQARQVTPDGESDEVGV IPSKRRVEKKERARLKTVKFNSKTRDKGQSFNDKRKKNLFSRKFPFYKNKDQSEQETSDADQHVTSNASDSESSYRGQEEYVLSYEPVNQ QEVNYTRPVIILGPMKDRINDDLISEFPDKFGSCVPHTTRPKRDYEVDGRDYHFVTSREQMEKDIQEHKFIEAGQYNNHLYGTSVQSVRE VAEKGKHCILDVSGNAIKRLQIAQLYPISIFIKPKSMENIMEMNKRLTEEQARKTFERAMKLEQEFTEHFTAIVQGDTLEDIYNQVKQII -------------------------------------------------------------- >6547_6547_10_ARL13B-DLG1_ARL13B_chr3_93722752_ENST00000394222_DLG1_chr3_196812627_ENST00000452595_length(amino acids)=444AA_BP=127 MFSLMASCCGWFKRWREPVRKVTLLMVGLDNAGKTATAKGIQGEYPEDVAPTVGFSKINLRQGKFEVTIFDLGGGIRIRGIWKNYYAESY GVIFVVDSSDEERMEETKEAMSEMLRHPRISGKPILVALFDYDKTKDSGLPSQGLNFKFGDILHVINASDDEWWQARQVTPDGESDEVGV IPSKRRVEKKERARLKTVKFNSKTRDKGEIPDDMGSKGLKHVTSNASDSESSYRGQEEYVLSYEPVNQQEVNYTRPVIILGPMKDRINDD LISEFPDKFGSCVPHTTRPKRDYEVDGRDYHFVTSREQMEKDIQEHKFIEAGQYNNHLYGTSVQSVREVAEKGKHCILDVSGNAIKRLQI -------------------------------------------------------------- >6547_6547_11_ARL13B-DLG1_ARL13B_chr3_93722752_ENST00000471138_DLG1_chr3_196812627_ENST00000314062_length(amino acids)=444AA_BP=127 MFSLMASCCGWFKRWREPVRKVTLLMVGLDNAGKTATAKGIQGEYPEDVAPTVGFSKINLRQGKFEVTIFDLGGGIRIRGIWKNYYAESY GVIFVVDSSDEERMEETKEAMSEMLRHPRISGKPILVALFDYDKTKDSGLPSQGLNFKFGDILHVINASDDEWWQARQVTPDGESDEVGV IPSKRRVEKKERARLKTVKFNSKTRDKGEIPDDMGSKGLKHVTSNASDSESSYRGQEEYVLSYEPVNQQEVNYTRPVIILGPMKDRINDD LISEFPDKFGSCVPHTTRPKRDYEVDGRDYHFVTSREQMEKDIQEHKFIEAGQYNNHLYGTSVQSVREVAEKGKHCILDVSGNAIKRLQI -------------------------------------------------------------- >6547_6547_12_ARL13B-DLG1_ARL13B_chr3_93722752_ENST00000471138_DLG1_chr3_196812627_ENST00000346964_length(amino acids)=466AA_BP=127 MFSLMASCCGWFKRWREPVRKVTLLMVGLDNAGKTATAKGIQGEYPEDVAPTVGFSKINLRQGKFEVTIFDLGGGIRIRGIWKNYYAESY GVIFVVDSSDEERMEETKEAMSEMLRHPRISGKPILVALFDYDKTKDSGLPSQGLNFKFGDILHVINASDDEWWQARQVTPDGESDEVGV IPSKRRVEKKERARLKTVKFNSKTRDKGQSFNDKRKKNLFSRKFPFYKNKDQSEQETSDADQHVTSNASDSESSYRGQEEYVLSYEPVNQ QEVNYTRPVIILGPMKDRINDDLISEFPDKFGSCVPHTTRPKRDYEVDGRDYHFVTSREQMEKDIQEHKFIEAGQYNNHLYGTSVQSVRE VAEKGKHCILDVSGNAIKRLQIAQLYPISIFIKPKSMENIMEMNKRLTEEQARKTFERAMKLEQEFTEHFTAIVQGDTLEDIYNQVKQII -------------------------------------------------------------- >6547_6547_13_ARL13B-DLG1_ARL13B_chr3_93722752_ENST00000471138_DLG1_chr3_196812627_ENST00000357674_length(amino acids)=466AA_BP=127 MFSLMASCCGWFKRWREPVRKVTLLMVGLDNAGKTATAKGIQGEYPEDVAPTVGFSKINLRQGKFEVTIFDLGGGIRIRGIWKNYYAESY GVIFVVDSSDEERMEETKEAMSEMLRHPRISGKPILVALFDYDKTKDSGLPSQGLNFKFGDILHVINASDDEWWQARQVTPDGESDEVGV IPSKRRVEKKERARLKTVKFNSKTRDKGQSFNDKRKKNLFSRKFPFYKNKDQSEQETSDADQHVTSNASDSESSYRGQEEYVLSYEPVNQ QEVNYTRPVIILGPMKDRINDDLISEFPDKFGSCVPHTTRPKRDYEVDGRDYHFVTSREQMEKDIQEHKFIEAGQYNNHLYGTSVQSVRE VAEKGKHCILDVSGNAIKRLQIAQLYPISIFIKPKSMENIMEMNKRLTEEQARKTFERAMKLEQEFTEHFTAIVQGDTLEDIYNQVKQII -------------------------------------------------------------- >6547_6547_14_ARL13B-DLG1_ARL13B_chr3_93722752_ENST00000471138_DLG1_chr3_196812627_ENST00000392382_length(amino acids)=445AA_BP=127 MFSLMASCCGWFKRWREPVRKVTLLMVGLDNAGKTATAKGIQGEYPEDVAPTVGFSKINLRQGKFEVTIFDLGGGIRIRGIWKNYYAESY GVIFVVDSSDEERMEETKEAMSEMLRHPRISGKPILVALFDYDKTKDSGLPSQGLNFKFGDILHVINASDDEWWQARQVTPDGESDEVGV IPSKRRVEKKERARLKTVKFNSKTRDKGEIPDDMGSKGLKHVTSNASDSESSYRGQEEYVLSYEPVNQQEVNYTRPVIILGPMKDRINDD LISEFPDKFGSCVPHTTRPKRDYEVDGRDYHFVTSREQMEKDIQEHKFIEAGQYNNHLYGTSVQSVREVAEKGKHCILDVSGNAIKRLQI -------------------------------------------------------------- >6547_6547_15_ARL13B-DLG1_ARL13B_chr3_93722752_ENST00000471138_DLG1_chr3_196812627_ENST00000419354_length(amino acids)=444AA_BP=127 MFSLMASCCGWFKRWREPVRKVTLLMVGLDNAGKTATAKGIQGEYPEDVAPTVGFSKINLRQGKFEVTIFDLGGGIRIRGIWKNYYAESY GVIFVVDSSDEERMEETKEAMSEMLRHPRISGKPILVALFDYDKTKDSGLPSQGLNFKFGDILHVINASDDEWWQARQVTPDGESDEVGV IPSKRRVEKKERARLKTVKFNSKTRDKGEIPDDMGSKGLKHVTSNASDSESSYRGQEEYVLSYEPVNQQEVNYTRPVIILGPMKDRINDD LISEFPDKFGSCVPHTTRPKRDYEVDGRDYHFVTSREQMEKDIQEHKFIEAGQYNNHLYGTSVQSVREVAEKGKHCILDVSGNAIKRLQI -------------------------------------------------------------- >6547_6547_16_ARL13B-DLG1_ARL13B_chr3_93722752_ENST00000471138_DLG1_chr3_196812627_ENST00000422288_length(amino acids)=444AA_BP=127 MFSLMASCCGWFKRWREPVRKVTLLMVGLDNAGKTATAKGIQGEYPEDVAPTVGFSKINLRQGKFEVTIFDLGGGIRIRGIWKNYYAESY GVIFVVDSSDEERMEETKEAMSEMLRHPRISGKPILVALFDYDKTKDSGLPSQGLNFKFGDILHVINASDDEWWQARQVTPDGESDEVGV IPSKRRVEKKERARLKTVKFNSKTRDKGEIPDDMGSKGLKHVTSNASDSESSYRGQEEYVLSYEPVNQQEVNYTRPVIILGPMKDRINDD LISEFPDKFGSCVPHTTRPKRDYEVDGRDYHFVTSREQMEKDIQEHKFIEAGQYNNHLYGTSVQSVREVAEKGKHCILDVSGNAIKRLQI -------------------------------------------------------------- >6547_6547_17_ARL13B-DLG1_ARL13B_chr3_93722752_ENST00000471138_DLG1_chr3_196812627_ENST00000443183_length(amino acids)=456AA_BP=127 MFSLMASCCGWFKRWREPVRKVTLLMVGLDNAGKTATAKGIQGEYPEDVAPTVGFSKINLRQGKFEVTIFDLGGGIRIRGIWKNYYAESY GVIFVVDSSDEERMEETKEAMSEMLRHPRISGKPILVALFDYDKTKDSGLPSQGLNFKFGDILHVINASDDEWWQARQVTPDGESDEVGV IPSKRRVEKKERARLKTVKFNSKTRDKGEIPDDMGSKGLKHVTSNASDSESSYLILITDEYGCSKGGQEEYVLSYEPVNQQEVNYTRPVI ILGPMKDRINDDLISEFPDKFGSCVPHTTRPKRDYEVDGRDYHFVTSREQMEKDIQEHKFIEAGQYNNHLYGTSVQSVREVAEKGKHCIL DVSGNAIKRLQIAQLYPISIFIKPKSMENIMEMNKRLTEEQARKTFERAMKLEQEFTEHFTAIVQGDTLEDIYNQVKQIIEEQSGSYIWV -------------------------------------------------------------- >6547_6547_18_ARL13B-DLG1_ARL13B_chr3_93722752_ENST00000471138_DLG1_chr3_196812627_ENST00000448528_length(amino acids)=444AA_BP=127 MFSLMASCCGWFKRWREPVRKVTLLMVGLDNAGKTATAKGIQGEYPEDVAPTVGFSKINLRQGKFEVTIFDLGGGIRIRGIWKNYYAESY GVIFVVDSSDEERMEETKEAMSEMLRHPRISGKPILVALFDYDKTKDSGLPSQGLNFKFGDILHVINASDDEWWQARQVTPDGESDEVGV IPSKRRVEKKERARLKTVKFNSKTRDKGEIPDDMGSKGLKHVTSNASDSESSYRGQEEYVLSYEPVNQQEVNYTRPVIILGPMKDRINDD LISEFPDKFGSCVPHTTRPKRDYEVDGRDYHFVTSREQMEKDIQEHKFIEAGQYNNHLYGTSVQSVREVAEKGKHCILDVSGNAIKRLQI -------------------------------------------------------------- >6547_6547_19_ARL13B-DLG1_ARL13B_chr3_93722752_ENST00000471138_DLG1_chr3_196812627_ENST00000450955_length(amino acids)=467AA_BP=127 MFSLMASCCGWFKRWREPVRKVTLLMVGLDNAGKTATAKGIQGEYPEDVAPTVGFSKINLRQGKFEVTIFDLGGGIRIRGIWKNYYAESY GVIFVVDSSDEERMEETKEAMSEMLRHPRISGKPILVALFDYDKTKDSGLPSQGLNFKFGDILHVINASDDEWWQARQVTPDGESDEVGV IPSKRRVEKKERARLKTVKFNSKTRDKGQSFNDKRKKNLFSRKFPFYKNKDQSEQETSDADQHVTSNASDSESSYRGQEEYVLSYEPVNQ QEVNYTRPVIILGPMKDRINDDLISEFPDKFGSCVPHTTRPKRDYEVDGRDYHFVTSREQMEKDIQEHKFIEAGQYNNHLYGTSVQSVRE VAEKGKHCILDVSGNAIKRLQIAQLYPISIFIKPKSMENIMEMNKRLTEEQARKTFERAMKLEQEFTEHFTAIVQGDTLEDIYNQVKQII -------------------------------------------------------------- >6547_6547_20_ARL13B-DLG1_ARL13B_chr3_93722752_ENST00000471138_DLG1_chr3_196812627_ENST00000452595_length(amino acids)=444AA_BP=127 MFSLMASCCGWFKRWREPVRKVTLLMVGLDNAGKTATAKGIQGEYPEDVAPTVGFSKINLRQGKFEVTIFDLGGGIRIRGIWKNYYAESY GVIFVVDSSDEERMEETKEAMSEMLRHPRISGKPILVALFDYDKTKDSGLPSQGLNFKFGDILHVINASDDEWWQARQVTPDGESDEVGV IPSKRRVEKKERARLKTVKFNSKTRDKGEIPDDMGSKGLKHVTSNASDSESSYRGQEEYVLSYEPVNQQEVNYTRPVIILGPMKDRINDD LISEFPDKFGSCVPHTTRPKRDYEVDGRDYHFVTSREQMEKDIQEHKFIEAGQYNNHLYGTSVQSVREVAEKGKHCILDVSGNAIKRLQI -------------------------------------------------------------- >6547_6547_21_ARL13B-DLG1_ARL13B_chr3_93722752_ENST00000535334_DLG1_chr3_196812627_ENST00000314062_length(amino acids)=403AA_BP=86 MSEYPEDVAPTVGFSKINLRQGKFEVTIFDLGGGIRIRGIWKNYYAESYGVIFVVDSSDEERMEETKEAMSEMLRHPRISGKPILVALFD YDKTKDSGLPSQGLNFKFGDILHVINASDDEWWQARQVTPDGESDEVGVIPSKRRVEKKERARLKTVKFNSKTRDKGEIPDDMGSKGLKH VTSNASDSESSYRGQEEYVLSYEPVNQQEVNYTRPVIILGPMKDRINDDLISEFPDKFGSCVPHTTRPKRDYEVDGRDYHFVTSREQMEK DIQEHKFIEAGQYNNHLYGTSVQSVREVAEKGKHCILDVSGNAIKRLQIAQLYPISIFIKPKSMENIMEMNKRLTEEQARKTFERAMKLE -------------------------------------------------------------- >6547_6547_22_ARL13B-DLG1_ARL13B_chr3_93722752_ENST00000535334_DLG1_chr3_196812627_ENST00000346964_length(amino acids)=425AA_BP=86 MSEYPEDVAPTVGFSKINLRQGKFEVTIFDLGGGIRIRGIWKNYYAESYGVIFVVDSSDEERMEETKEAMSEMLRHPRISGKPILVALFD YDKTKDSGLPSQGLNFKFGDILHVINASDDEWWQARQVTPDGESDEVGVIPSKRRVEKKERARLKTVKFNSKTRDKGQSFNDKRKKNLFS RKFPFYKNKDQSEQETSDADQHVTSNASDSESSYRGQEEYVLSYEPVNQQEVNYTRPVIILGPMKDRINDDLISEFPDKFGSCVPHTTRP KRDYEVDGRDYHFVTSREQMEKDIQEHKFIEAGQYNNHLYGTSVQSVREVAEKGKHCILDVSGNAIKRLQIAQLYPISIFIKPKSMENIM -------------------------------------------------------------- >6547_6547_23_ARL13B-DLG1_ARL13B_chr3_93722752_ENST00000535334_DLG1_chr3_196812627_ENST00000357674_length(amino acids)=425AA_BP=86 MSEYPEDVAPTVGFSKINLRQGKFEVTIFDLGGGIRIRGIWKNYYAESYGVIFVVDSSDEERMEETKEAMSEMLRHPRISGKPILVALFD YDKTKDSGLPSQGLNFKFGDILHVINASDDEWWQARQVTPDGESDEVGVIPSKRRVEKKERARLKTVKFNSKTRDKGQSFNDKRKKNLFS RKFPFYKNKDQSEQETSDADQHVTSNASDSESSYRGQEEYVLSYEPVNQQEVNYTRPVIILGPMKDRINDDLISEFPDKFGSCVPHTTRP KRDYEVDGRDYHFVTSREQMEKDIQEHKFIEAGQYNNHLYGTSVQSVREVAEKGKHCILDVSGNAIKRLQIAQLYPISIFIKPKSMENIM -------------------------------------------------------------- >6547_6547_24_ARL13B-DLG1_ARL13B_chr3_93722752_ENST00000535334_DLG1_chr3_196812627_ENST00000392382_length(amino acids)=404AA_BP=86 MSEYPEDVAPTVGFSKINLRQGKFEVTIFDLGGGIRIRGIWKNYYAESYGVIFVVDSSDEERMEETKEAMSEMLRHPRISGKPILVALFD YDKTKDSGLPSQGLNFKFGDILHVINASDDEWWQARQVTPDGESDEVGVIPSKRRVEKKERARLKTVKFNSKTRDKGEIPDDMGSKGLKH VTSNASDSESSYRGQEEYVLSYEPVNQQEVNYTRPVIILGPMKDRINDDLISEFPDKFGSCVPHTTRPKRDYEVDGRDYHFVTSREQMEK DIQEHKFIEAGQYNNHLYGTSVQSVREVAEKGKHCILDVSGNAIKRLQIAQLYPISIFIKPKSMENIMEMNKRLTEEQARKTFERAMKLE -------------------------------------------------------------- >6547_6547_25_ARL13B-DLG1_ARL13B_chr3_93722752_ENST00000535334_DLG1_chr3_196812627_ENST00000419354_length(amino acids)=403AA_BP=86 MSEYPEDVAPTVGFSKINLRQGKFEVTIFDLGGGIRIRGIWKNYYAESYGVIFVVDSSDEERMEETKEAMSEMLRHPRISGKPILVALFD YDKTKDSGLPSQGLNFKFGDILHVINASDDEWWQARQVTPDGESDEVGVIPSKRRVEKKERARLKTVKFNSKTRDKGEIPDDMGSKGLKH VTSNASDSESSYRGQEEYVLSYEPVNQQEVNYTRPVIILGPMKDRINDDLISEFPDKFGSCVPHTTRPKRDYEVDGRDYHFVTSREQMEK DIQEHKFIEAGQYNNHLYGTSVQSVREVAEKGKHCILDVSGNAIKRLQIAQLYPISIFIKPKSMENIMEMNKRLTEEQARKTFERAMKLE -------------------------------------------------------------- >6547_6547_26_ARL13B-DLG1_ARL13B_chr3_93722752_ENST00000535334_DLG1_chr3_196812627_ENST00000422288_length(amino acids)=403AA_BP=86 MSEYPEDVAPTVGFSKINLRQGKFEVTIFDLGGGIRIRGIWKNYYAESYGVIFVVDSSDEERMEETKEAMSEMLRHPRISGKPILVALFD YDKTKDSGLPSQGLNFKFGDILHVINASDDEWWQARQVTPDGESDEVGVIPSKRRVEKKERARLKTVKFNSKTRDKGEIPDDMGSKGLKH VTSNASDSESSYRGQEEYVLSYEPVNQQEVNYTRPVIILGPMKDRINDDLISEFPDKFGSCVPHTTRPKRDYEVDGRDYHFVTSREQMEK DIQEHKFIEAGQYNNHLYGTSVQSVREVAEKGKHCILDVSGNAIKRLQIAQLYPISIFIKPKSMENIMEMNKRLTEEQARKTFERAMKLE -------------------------------------------------------------- >6547_6547_27_ARL13B-DLG1_ARL13B_chr3_93722752_ENST00000535334_DLG1_chr3_196812627_ENST00000443183_length(amino acids)=415AA_BP=86 MSEYPEDVAPTVGFSKINLRQGKFEVTIFDLGGGIRIRGIWKNYYAESYGVIFVVDSSDEERMEETKEAMSEMLRHPRISGKPILVALFD YDKTKDSGLPSQGLNFKFGDILHVINASDDEWWQARQVTPDGESDEVGVIPSKRRVEKKERARLKTVKFNSKTRDKGEIPDDMGSKGLKH VTSNASDSESSYLILITDEYGCSKGGQEEYVLSYEPVNQQEVNYTRPVIILGPMKDRINDDLISEFPDKFGSCVPHTTRPKRDYEVDGRD YHFVTSREQMEKDIQEHKFIEAGQYNNHLYGTSVQSVREVAEKGKHCILDVSGNAIKRLQIAQLYPISIFIKPKSMENIMEMNKRLTEEQ -------------------------------------------------------------- >6547_6547_28_ARL13B-DLG1_ARL13B_chr3_93722752_ENST00000535334_DLG1_chr3_196812627_ENST00000448528_length(amino acids)=403AA_BP=86 MSEYPEDVAPTVGFSKINLRQGKFEVTIFDLGGGIRIRGIWKNYYAESYGVIFVVDSSDEERMEETKEAMSEMLRHPRISGKPILVALFD YDKTKDSGLPSQGLNFKFGDILHVINASDDEWWQARQVTPDGESDEVGVIPSKRRVEKKERARLKTVKFNSKTRDKGEIPDDMGSKGLKH VTSNASDSESSYRGQEEYVLSYEPVNQQEVNYTRPVIILGPMKDRINDDLISEFPDKFGSCVPHTTRPKRDYEVDGRDYHFVTSREQMEK DIQEHKFIEAGQYNNHLYGTSVQSVREVAEKGKHCILDVSGNAIKRLQIAQLYPISIFIKPKSMENIMEMNKRLTEEQARKTFERAMKLE -------------------------------------------------------------- >6547_6547_29_ARL13B-DLG1_ARL13B_chr3_93722752_ENST00000535334_DLG1_chr3_196812627_ENST00000450955_length(amino acids)=426AA_BP=86 MSEYPEDVAPTVGFSKINLRQGKFEVTIFDLGGGIRIRGIWKNYYAESYGVIFVVDSSDEERMEETKEAMSEMLRHPRISGKPILVALFD YDKTKDSGLPSQGLNFKFGDILHVINASDDEWWQARQVTPDGESDEVGVIPSKRRVEKKERARLKTVKFNSKTRDKGQSFNDKRKKNLFS RKFPFYKNKDQSEQETSDADQHVTSNASDSESSYRGQEEYVLSYEPVNQQEVNYTRPVIILGPMKDRINDDLISEFPDKFGSCVPHTTRP KRDYEVDGRDYHFVTSREQMEKDIQEHKFIEAGQYNNHLYGTSVQSVREVAEKGKHCILDVSGNAIKRLQIAQLYPISIFIKPKSMENIM -------------------------------------------------------------- >6547_6547_30_ARL13B-DLG1_ARL13B_chr3_93722752_ENST00000535334_DLG1_chr3_196812627_ENST00000452595_length(amino acids)=403AA_BP=86 MSEYPEDVAPTVGFSKINLRQGKFEVTIFDLGGGIRIRGIWKNYYAESYGVIFVVDSSDEERMEETKEAMSEMLRHPRISGKPILVALFD YDKTKDSGLPSQGLNFKFGDILHVINASDDEWWQARQVTPDGESDEVGVIPSKRRVEKKERARLKTVKFNSKTRDKGEIPDDMGSKGLKH VTSNASDSESSYRGQEEYVLSYEPVNQQEVNYTRPVIILGPMKDRINDDLISEFPDKFGSCVPHTTRPKRDYEVDGRDYHFVTSREQMEK DIQEHKFIEAGQYNNHLYGTSVQSVREVAEKGKHCILDVSGNAIKRLQIAQLYPISIFIKPKSMENIMEMNKRLTEEQARKTFERAMKLE -------------------------------------------------------------- |
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Fusion Protein Functional Features |
| Four levels of functional features of fusion genes Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr3:93722752/chr3:196812627) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
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| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| ARL13B | DLG1 |
| FUNCTION: Cilium-specific protein required to control the microtubule-based, ciliary axoneme structure. May act by maintaining the association between IFT subcomplexes A and B. Binds GTP but is not able to hydrolyze it; the GTPase activity remains unclear. Required to pattern the neural tube. Involved in cerebral cortex development: required for the initial formation of a polarized radial glial scaffold, the first step in the construction of the cerebral cortex, by regulating ciliary signaling. Regulates the migration and placement of postmitotic interneurons in the developing cerebral cortex. May regulate endocytic recycling traffic; however, additional evidence is required to confirm these data. {ECO:0000269|PubMed:23150559}. | FUNCTION: Essential multidomain scaffolding protein required for normal development (By similarity). Recruits channels, receptors and signaling molecules to discrete plasma membrane domains in polarized cells. May play a role in adherens junction assembly, signal transduction, cell proliferation, synaptogenesis and lymphocyte activation. Regulates the excitability of cardiac myocytes by modulating the functional expression of Kv4 channels. Functional regulator of Kv1.5 channel. During long-term depression in hippocampal neurons, it recruits ADAM10 to the plasma membrane (PubMed:23676497). {ECO:0000250, ECO:0000269|PubMed:10656683, ECO:0000269|PubMed:12445884, ECO:0000269|PubMed:14699157, ECO:0000269|PubMed:15263016, ECO:0000269|PubMed:19213956, ECO:0000269|PubMed:20605917, ECO:0000269|PubMed:23676497}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
| - Retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | ARL13B | chr3:93722752 | chr3:196812627 | ENST00000394222 | + | 3 | 10 | 28_35 | 126.66666666666667 | 429.0 | Nucleotide binding | GTP |
| Hgene | ARL13B | chr3:93722752 | chr3:196812627 | ENST00000394222 | + | 3 | 10 | 71_75 | 126.66666666666667 | 429.0 | Nucleotide binding | GTP |
| Hgene | ARL13B | chr3:93722752 | chr3:196812627 | ENST00000471138 | + | 3 | 11 | 28_35 | 126.66666666666667 | 524.0 | Nucleotide binding | GTP |
| Hgene | ARL13B | chr3:93722752 | chr3:196812627 | ENST00000471138 | + | 3 | 11 | 71_75 | 126.66666666666667 | 524.0 | Nucleotide binding | GTP |
| Tgene | DLG1 | chr3:93722752 | chr3:196812627 | ENST00000314062 | 13 | 24 | 581_651 | 535.6666666666666 | 854.0 | Domain | SH3 | |
| Tgene | DLG1 | chr3:93722752 | chr3:196812627 | ENST00000314062 | 13 | 24 | 714_889 | 535.6666666666666 | 854.0 | Domain | Guanylate kinase-like | |
| Tgene | DLG1 | chr3:93722752 | chr3:196812627 | ENST00000346964 | 15 | 26 | 714_889 | 586.6666666666666 | 927.0 | Domain | Guanylate kinase-like | |
| Tgene | DLG1 | chr3:93722752 | chr3:196812627 | ENST00000357674 | 14 | 25 | 581_651 | 553.6666666666666 | 894.0 | Domain | SH3 | |
| Tgene | DLG1 | chr3:93722752 | chr3:196812627 | ENST00000357674 | 14 | 25 | 714_889 | 553.6666666666666 | 894.0 | Domain | Guanylate kinase-like | |
| Tgene | DLG1 | chr3:93722752 | chr3:196812627 | ENST00000392382 | 14 | 25 | 581_651 | 553.6666666666666 | 872.0 | Domain | SH3 | |
| Tgene | DLG1 | chr3:93722752 | chr3:196812627 | ENST00000392382 | 14 | 25 | 714_889 | 553.6666666666666 | 872.0 | Domain | Guanylate kinase-like | |
| Tgene | DLG1 | chr3:93722752 | chr3:196812627 | ENST00000419354 | 15 | 26 | 714_889 | 586.6666666666666 | 905.0 | Domain | Guanylate kinase-like | |
| Tgene | DLG1 | chr3:93722752 | chr3:196812627 | ENST00000422288 | 12 | 23 | 581_651 | 535.6666666666666 | 854.0 | Domain | SH3 | |
| Tgene | DLG1 | chr3:93722752 | chr3:196812627 | ENST00000422288 | 12 | 23 | 714_889 | 535.6666666666666 | 854.0 | Domain | Guanylate kinase-like | |
| Tgene | DLG1 | chr3:93722752 | chr3:196812627 | ENST00000443183 | 10 | 22 | 581_651 | 470.6666666666667 | 801.0 | Domain | SH3 | |
| Tgene | DLG1 | chr3:93722752 | chr3:196812627 | ENST00000443183 | 10 | 22 | 714_889 | 470.6666666666667 | 801.0 | Domain | Guanylate kinase-like | |
| Tgene | DLG1 | chr3:93722752 | chr3:196812627 | ENST00000448528 | 15 | 26 | 714_889 | 586.6666666666666 | 905.0 | Domain | Guanylate kinase-like | |
| Tgene | DLG1 | chr3:93722752 | chr3:196812627 | ENST00000450955 | 13 | 24 | 581_651 | 553.6666666666666 | 894.0 | Domain | SH3 | |
| Tgene | DLG1 | chr3:93722752 | chr3:196812627 | ENST00000450955 | 13 | 24 | 714_889 | 553.6666666666666 | 894.0 | Domain | Guanylate kinase-like | |
| Tgene | DLG1 | chr3:93722752 | chr3:196812627 | ENST00000452595 | 10 | 21 | 581_651 | 470.6666666666667 | 789.0 | Domain | SH3 | |
| Tgene | DLG1 | chr3:93722752 | chr3:196812627 | ENST00000452595 | 10 | 21 | 714_889 | 470.6666666666667 | 789.0 | Domain | Guanylate kinase-like |
| - Not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | ARL13B | chr3:93722752 | chr3:196812627 | ENST00000303097 | + | 1 | 8 | 192_245 | 0 | 322.0 | Coiled coil | Ontology_term=ECO:0000255 |
| Hgene | ARL13B | chr3:93722752 | chr3:196812627 | ENST00000394222 | + | 3 | 10 | 192_245 | 126.66666666666667 | 429.0 | Coiled coil | Ontology_term=ECO:0000255 |
| Hgene | ARL13B | chr3:93722752 | chr3:196812627 | ENST00000471138 | + | 3 | 11 | 192_245 | 126.66666666666667 | 524.0 | Coiled coil | Ontology_term=ECO:0000255 |
| Hgene | ARL13B | chr3:93722752 | chr3:196812627 | ENST00000535334 | + | 2 | 9 | 192_245 | 23.666666666666668 | 326.0 | Coiled coil | Ontology_term=ECO:0000255 |
| Hgene | ARL13B | chr3:93722752 | chr3:196812627 | ENST00000303097 | + | 1 | 8 | 369_419 | 0 | 322.0 | Compositional bias | Note=Pro-rich |
| Hgene | ARL13B | chr3:93722752 | chr3:196812627 | ENST00000394222 | + | 3 | 10 | 369_419 | 126.66666666666667 | 429.0 | Compositional bias | Note=Pro-rich |
| Hgene | ARL13B | chr3:93722752 | chr3:196812627 | ENST00000471138 | + | 3 | 11 | 369_419 | 126.66666666666667 | 524.0 | Compositional bias | Note=Pro-rich |
| Hgene | ARL13B | chr3:93722752 | chr3:196812627 | ENST00000535334 | + | 2 | 9 | 369_419 | 23.666666666666668 | 326.0 | Compositional bias | Note=Pro-rich |
| Hgene | ARL13B | chr3:93722752 | chr3:196812627 | ENST00000303097 | + | 1 | 8 | 130_133 | 0 | 322.0 | Nucleotide binding | GTP |
| Hgene | ARL13B | chr3:93722752 | chr3:196812627 | ENST00000303097 | + | 1 | 8 | 28_35 | 0 | 322.0 | Nucleotide binding | GTP |
| Hgene | ARL13B | chr3:93722752 | chr3:196812627 | ENST00000303097 | + | 1 | 8 | 71_75 | 0 | 322.0 | Nucleotide binding | GTP |
| Hgene | ARL13B | chr3:93722752 | chr3:196812627 | ENST00000394222 | + | 3 | 10 | 130_133 | 126.66666666666667 | 429.0 | Nucleotide binding | GTP |
| Hgene | ARL13B | chr3:93722752 | chr3:196812627 | ENST00000471138 | + | 3 | 11 | 130_133 | 126.66666666666667 | 524.0 | Nucleotide binding | GTP |
| Hgene | ARL13B | chr3:93722752 | chr3:196812627 | ENST00000535334 | + | 2 | 9 | 130_133 | 23.666666666666668 | 326.0 | Nucleotide binding | GTP |
| Hgene | ARL13B | chr3:93722752 | chr3:196812627 | ENST00000535334 | + | 2 | 9 | 28_35 | 23.666666666666668 | 326.0 | Nucleotide binding | GTP |
| Hgene | ARL13B | chr3:93722752 | chr3:196812627 | ENST00000535334 | + | 2 | 9 | 71_75 | 23.666666666666668 | 326.0 | Nucleotide binding | GTP |
| Tgene | DLG1 | chr3:93722752 | chr3:196812627 | ENST00000314062 | 13 | 24 | 224_310 | 535.6666666666666 | 854.0 | Domain | PDZ 1 | |
| Tgene | DLG1 | chr3:93722752 | chr3:196812627 | ENST00000314062 | 13 | 24 | 319_405 | 535.6666666666666 | 854.0 | Domain | PDZ 2 | |
| Tgene | DLG1 | chr3:93722752 | chr3:196812627 | ENST00000314062 | 13 | 24 | 466_546 | 535.6666666666666 | 854.0 | Domain | PDZ 3 | |
| Tgene | DLG1 | chr3:93722752 | chr3:196812627 | ENST00000314062 | 13 | 24 | 4_64 | 535.6666666666666 | 854.0 | Domain | L27 | |
| Tgene | DLG1 | chr3:93722752 | chr3:196812627 | ENST00000346964 | 15 | 26 | 224_310 | 586.6666666666666 | 927.0 | Domain | PDZ 1 | |
| Tgene | DLG1 | chr3:93722752 | chr3:196812627 | ENST00000346964 | 15 | 26 | 319_405 | 586.6666666666666 | 927.0 | Domain | PDZ 2 | |
| Tgene | DLG1 | chr3:93722752 | chr3:196812627 | ENST00000346964 | 15 | 26 | 466_546 | 586.6666666666666 | 927.0 | Domain | PDZ 3 | |
| Tgene | DLG1 | chr3:93722752 | chr3:196812627 | ENST00000346964 | 15 | 26 | 4_64 | 586.6666666666666 | 927.0 | Domain | L27 | |
| Tgene | DLG1 | chr3:93722752 | chr3:196812627 | ENST00000346964 | 15 | 26 | 581_651 | 586.6666666666666 | 927.0 | Domain | SH3 | |
| Tgene | DLG1 | chr3:93722752 | chr3:196812627 | ENST00000357674 | 14 | 25 | 224_310 | 553.6666666666666 | 894.0 | Domain | PDZ 1 | |
| Tgene | DLG1 | chr3:93722752 | chr3:196812627 | ENST00000357674 | 14 | 25 | 319_405 | 553.6666666666666 | 894.0 | Domain | PDZ 2 | |
| Tgene | DLG1 | chr3:93722752 | chr3:196812627 | ENST00000357674 | 14 | 25 | 466_546 | 553.6666666666666 | 894.0 | Domain | PDZ 3 | |
| Tgene | DLG1 | chr3:93722752 | chr3:196812627 | ENST00000357674 | 14 | 25 | 4_64 | 553.6666666666666 | 894.0 | Domain | L27 | |
| Tgene | DLG1 | chr3:93722752 | chr3:196812627 | ENST00000392382 | 14 | 25 | 224_310 | 553.6666666666666 | 872.0 | Domain | PDZ 1 | |
| Tgene | DLG1 | chr3:93722752 | chr3:196812627 | ENST00000392382 | 14 | 25 | 319_405 | 553.6666666666666 | 872.0 | Domain | PDZ 2 | |
| Tgene | DLG1 | chr3:93722752 | chr3:196812627 | ENST00000392382 | 14 | 25 | 466_546 | 553.6666666666666 | 872.0 | Domain | PDZ 3 | |
| Tgene | DLG1 | chr3:93722752 | chr3:196812627 | ENST00000392382 | 14 | 25 | 4_64 | 553.6666666666666 | 872.0 | Domain | L27 | |
| Tgene | DLG1 | chr3:93722752 | chr3:196812627 | ENST00000419354 | 15 | 26 | 224_310 | 586.6666666666666 | 905.0 | Domain | PDZ 1 | |
| Tgene | DLG1 | chr3:93722752 | chr3:196812627 | ENST00000419354 | 15 | 26 | 319_405 | 586.6666666666666 | 905.0 | Domain | PDZ 2 | |
| Tgene | DLG1 | chr3:93722752 | chr3:196812627 | ENST00000419354 | 15 | 26 | 466_546 | 586.6666666666666 | 905.0 | Domain | PDZ 3 | |
| Tgene | DLG1 | chr3:93722752 | chr3:196812627 | ENST00000419354 | 15 | 26 | 4_64 | 586.6666666666666 | 905.0 | Domain | L27 | |
| Tgene | DLG1 | chr3:93722752 | chr3:196812627 | ENST00000419354 | 15 | 26 | 581_651 | 586.6666666666666 | 905.0 | Domain | SH3 | |
| Tgene | DLG1 | chr3:93722752 | chr3:196812627 | ENST00000422288 | 12 | 23 | 224_310 | 535.6666666666666 | 854.0 | Domain | PDZ 1 | |
| Tgene | DLG1 | chr3:93722752 | chr3:196812627 | ENST00000422288 | 12 | 23 | 319_405 | 535.6666666666666 | 854.0 | Domain | PDZ 2 | |
| Tgene | DLG1 | chr3:93722752 | chr3:196812627 | ENST00000422288 | 12 | 23 | 466_546 | 535.6666666666666 | 854.0 | Domain | PDZ 3 | |
| Tgene | DLG1 | chr3:93722752 | chr3:196812627 | ENST00000422288 | 12 | 23 | 4_64 | 535.6666666666666 | 854.0 | Domain | L27 | |
| Tgene | DLG1 | chr3:93722752 | chr3:196812627 | ENST00000443183 | 10 | 22 | 224_310 | 470.6666666666667 | 801.0 | Domain | PDZ 1 | |
| Tgene | DLG1 | chr3:93722752 | chr3:196812627 | ENST00000443183 | 10 | 22 | 319_405 | 470.6666666666667 | 801.0 | Domain | PDZ 2 | |
| Tgene | DLG1 | chr3:93722752 | chr3:196812627 | ENST00000443183 | 10 | 22 | 466_546 | 470.6666666666667 | 801.0 | Domain | PDZ 3 | |
| Tgene | DLG1 | chr3:93722752 | chr3:196812627 | ENST00000443183 | 10 | 22 | 4_64 | 470.6666666666667 | 801.0 | Domain | L27 | |
| Tgene | DLG1 | chr3:93722752 | chr3:196812627 | ENST00000448528 | 15 | 26 | 224_310 | 586.6666666666666 | 905.0 | Domain | PDZ 1 | |
| Tgene | DLG1 | chr3:93722752 | chr3:196812627 | ENST00000448528 | 15 | 26 | 319_405 | 586.6666666666666 | 905.0 | Domain | PDZ 2 | |
| Tgene | DLG1 | chr3:93722752 | chr3:196812627 | ENST00000448528 | 15 | 26 | 466_546 | 586.6666666666666 | 905.0 | Domain | PDZ 3 | |
| Tgene | DLG1 | chr3:93722752 | chr3:196812627 | ENST00000448528 | 15 | 26 | 4_64 | 586.6666666666666 | 905.0 | Domain | L27 | |
| Tgene | DLG1 | chr3:93722752 | chr3:196812627 | ENST00000448528 | 15 | 26 | 581_651 | 586.6666666666666 | 905.0 | Domain | SH3 | |
| Tgene | DLG1 | chr3:93722752 | chr3:196812627 | ENST00000450955 | 13 | 24 | 224_310 | 553.6666666666666 | 894.0 | Domain | PDZ 1 | |
| Tgene | DLG1 | chr3:93722752 | chr3:196812627 | ENST00000450955 | 13 | 24 | 319_405 | 553.6666666666666 | 894.0 | Domain | PDZ 2 | |
| Tgene | DLG1 | chr3:93722752 | chr3:196812627 | ENST00000450955 | 13 | 24 | 466_546 | 553.6666666666666 | 894.0 | Domain | PDZ 3 | |
| Tgene | DLG1 | chr3:93722752 | chr3:196812627 | ENST00000450955 | 13 | 24 | 4_64 | 553.6666666666666 | 894.0 | Domain | L27 | |
| Tgene | DLG1 | chr3:93722752 | chr3:196812627 | ENST00000452595 | 10 | 21 | 224_310 | 470.6666666666667 | 789.0 | Domain | PDZ 1 | |
| Tgene | DLG1 | chr3:93722752 | chr3:196812627 | ENST00000452595 | 10 | 21 | 319_405 | 470.6666666666667 | 789.0 | Domain | PDZ 2 | |
| Tgene | DLG1 | chr3:93722752 | chr3:196812627 | ENST00000452595 | 10 | 21 | 466_546 | 470.6666666666667 | 789.0 | Domain | PDZ 3 | |
| Tgene | DLG1 | chr3:93722752 | chr3:196812627 | ENST00000452595 | 10 | 21 | 4_64 | 470.6666666666667 | 789.0 | Domain | L27 |
Top |
Fusion Protein-Protein Interaction |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in |
| Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160) |
| Gene | PPI interactors |
| Protein-protein interactors based on sequence similarity (STRING) |
| Gene | STRING network |
| ARL13B | |
| DLG1 |
| - Retained interactions in fusion protein (protein functional feature from UniProt). |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost interactions due to fusion (protein functional feature from UniProt). |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| Tgene | DLG1 | chr3:93722752 | chr3:196812627 | ENST00000314062 | 13 | 24 | 162_212 | 535.6666666666666 | 854.0 | SH3 domains | |
| Tgene | DLG1 | chr3:93722752 | chr3:196812627 | ENST00000346964 | 15 | 26 | 162_212 | 586.6666666666666 | 927.0 | SH3 domains | |
| Tgene | DLG1 | chr3:93722752 | chr3:196812627 | ENST00000357674 | 14 | 25 | 162_212 | 553.6666666666666 | 894.0 | SH3 domains | |
| Tgene | DLG1 | chr3:93722752 | chr3:196812627 | ENST00000392382 | 14 | 25 | 162_212 | 553.6666666666666 | 872.0 | SH3 domains | |
| Tgene | DLG1 | chr3:93722752 | chr3:196812627 | ENST00000419354 | 15 | 26 | 162_212 | 586.6666666666666 | 905.0 | SH3 domains | |
| Tgene | DLG1 | chr3:93722752 | chr3:196812627 | ENST00000422288 | 12 | 23 | 162_212 | 535.6666666666666 | 854.0 | SH3 domains | |
| Tgene | DLG1 | chr3:93722752 | chr3:196812627 | ENST00000443183 | 10 | 22 | 162_212 | 470.6666666666667 | 801.0 | SH3 domains | |
| Tgene | DLG1 | chr3:93722752 | chr3:196812627 | ENST00000448528 | 15 | 26 | 162_212 | 586.6666666666666 | 905.0 | SH3 domains | |
| Tgene | DLG1 | chr3:93722752 | chr3:196812627 | ENST00000450955 | 13 | 24 | 162_212 | 553.6666666666666 | 894.0 | SH3 domains | |
| Tgene | DLG1 | chr3:93722752 | chr3:196812627 | ENST00000452595 | 10 | 21 | 162_212 | 470.6666666666667 | 789.0 | SH3 domains |
Top |
Related Drugs to ARL13B-DLG1 |
| Drugs used for this fusion-positive patient. (Manual curation of PubMed, 04-30-2022 + MyCancerGenome) |
| Hgene | Tgene | Drug | Source | PMID |
Top |
Related Diseases to ARL13B-DLG1 |
| Diseases that have this fusion gene. (Manual curation of PubMed, 04-30-2022 + MyCancerGenome) |
| Hgene | Tgene | Disease | Source | PMID |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
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