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	Fusion Gene Summary
	Fusion Gene Sample Information
	Fusion ORF Analysis
	Fusion Amino Acid Sequences
	Fusion Protein Functional Features
	Fusion Protein-Protein Interaction
	Related drugs with this fusion protein
	Related disease with this fusion protein

Fusion Protein:PLAUR-CREB3L2

Fusion Protein Summary

Fusion gene summary

Fusion partner gene information	Fusion gene name: PLAUR-CREB3L2
	FusionPDB ID: 65925
	FusionGDB2.0 ID: 65925
		Hgene	Tgene
	Gene symbol	PLAUR	CREB3L2
	Gene ID	5329	64764
	Gene name	plasminogen activator, urokinase receptor	cAMP responsive element binding protein 3 like 2
	Synonyms	CD87\|U-PAR\|UPAR\|URKR	BBF2H7
	Cytomap	19q13.31	7q33
	Type of gene	protein-coding	protein-coding
	Description	urokinase plasminogen activator surface receptormonocyte activation antigen Mo3u-plasminogen activator receptor form 2urokinase-type plasminogen activator (uPA) receptor	cyclic AMP-responsive element-binding protein 3-like protein 2B-ZIB transcription factorBBF2 human homolog on chromosome 7FUS/BBF2H7 proteinTCAG_1951439basic transcription factor 2cAMP-responsive element-binding protein 3-like protein 2
	Modification date	20200329	20200313
	UniProtAcc	.	Q70SY1
Ensembl transtripts involved in fusion gene	ENST ids	ENST00000221264, ENST00000339082, ENST00000340093, ENST00000601723,	ENST00000468127, ENST00000330387, ENST00000452463, ENST00000456390, ENST00000458726,
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)	* DoF score	9 X 6 X 8=432	5 X 10 X 5=250
	# samples	10	9
	** MAII score	log2(10/432*10)=-2.11103131238874 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(9/250*10)=-1.47393118833241 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)	PubMed: PLAUR [Title/Abstract] AND CREB3L2 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)	PLAUR(44169468)-CREB3L2(137600758), # samples:1
Anticipated loss of major functional domain due to fusion event.	PLAUR-CREB3L2 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. PLAUR-CREB3L2 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. PLAUR-CREB3L2 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. PLAUR-CREB3L2 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	PLAUR	GO:0043388	positive regulation of DNA binding	22984561
Tgene	CREB3L2	GO:0045893	positive regulation of transcription, DNA-templated	17178827

Fusion gene breakpoints across PLAUR (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across CREB3L2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

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Fusion Gene Sample Information

Fusion gene information from FusionGDB2.0.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	Non-Cancer	ERR315424	PLAUR	chr19	44169468	-	CREB3L2	chr7	137600758	-

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Fusion ORF Analysis

Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000339082	PLAUR	chr19	44169468	-	ENST00000330387	CREB3L2	chr7	137600758	-	7097	356	46	1599	517
ENST00000339082	PLAUR	chr19	44169468	-	ENST00000456390	CREB3L2	chr7	137600758	-	2035	356	46	1419	457
ENST00000339082	PLAUR	chr19	44169468	-	ENST00000452463	CREB3L2	chr7	137600758	-	800	356	46	783	245
ENST00000339082	PLAUR	chr19	44169468	-	ENST00000458726	CREB3L2	chr7	137600758	-	787	356	46	783	245
ENST00000601723	PLAUR	chr19	44169468	-	ENST00000330387	CREB3L2	chr7	137600758	-	7084	343	33	1586	517
ENST00000601723	PLAUR	chr19	44169468	-	ENST00000456390	CREB3L2	chr7	137600758	-	2022	343	33	1406	457
ENST00000601723	PLAUR	chr19	44169468	-	ENST00000452463	CREB3L2	chr7	137600758	-	787	343	33	770	245
ENST00000601723	PLAUR	chr19	44169468	-	ENST00000458726	CREB3L2	chr7	137600758	-	774	343	33	770	245
ENST00000340093	PLAUR	chr19	44169468	-	ENST00000330387	CREB3L2	chr7	137600758	-	7281	540	170	1783	537
ENST00000340093	PLAUR	chr19	44169468	-	ENST00000456390	CREB3L2	chr7	137600758	-	2219	540	170	1603	477
ENST00000340093	PLAUR	chr19	44169468	-	ENST00000452463	CREB3L2	chr7	137600758	-	984	540	170	967	265
ENST00000340093	PLAUR	chr19	44169468	-	ENST00000458726	CREB3L2	chr7	137600758	-	971	540	170	967	265
ENST00000221264	PLAUR	chr19	44169468	-	ENST00000330387	CREB3L2	chr7	137600758	-	7478	737	367	1980	537
ENST00000221264	PLAUR	chr19	44169468	-	ENST00000456390	CREB3L2	chr7	137600758	-	2416	737	367	1800	477
ENST00000221264	PLAUR	chr19	44169468	-	ENST00000452463	CREB3L2	chr7	137600758	-	1181	737	367	1164	265
ENST00000221264	PLAUR	chr19	44169468	-	ENST00000458726	CREB3L2	chr7	137600758	-	1168	737	367	1164	265

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000339082	ENST00000330387	PLAUR	chr19	44169468	-	CREB3L2	chr7	137600758	-	0.000433583	0.9995664
ENST00000339082	ENST00000456390	PLAUR	chr19	44169468	-	CREB3L2	chr7	137600758	-	0.004329003	0.99567103
ENST00000339082	ENST00000452463	PLAUR	chr19	44169468	-	CREB3L2	chr7	137600758	-	0.015472943	0.9845271
ENST00000339082	ENST00000458726	PLAUR	chr19	44169468	-	CREB3L2	chr7	137600758	-	0.014421614	0.9855784
ENST00000601723	ENST00000330387	PLAUR	chr19	44169468	-	CREB3L2	chr7	137600758	-	0.000424396	0.99957556
ENST00000601723	ENST00000456390	PLAUR	chr19	44169468	-	CREB3L2	chr7	137600758	-	0.00397638	0.99602365
ENST00000601723	ENST00000452463	PLAUR	chr19	44169468	-	CREB3L2	chr7	137600758	-	0.01609773	0.9839023
ENST00000601723	ENST00000458726	PLAUR	chr19	44169468	-	CREB3L2	chr7	137600758	-	0.014683683	0.98531634
ENST00000340093	ENST00000330387	PLAUR	chr19	44169468	-	CREB3L2	chr7	137600758	-	0.000452728	0.9995473
ENST00000340093	ENST00000456390	PLAUR	chr19	44169468	-	CREB3L2	chr7	137600758	-	0.004710333	0.9952897
ENST00000340093	ENST00000452463	PLAUR	chr19	44169468	-	CREB3L2	chr7	137600758	-	0.0110072	0.98899275
ENST00000340093	ENST00000458726	PLAUR	chr19	44169468	-	CREB3L2	chr7	137600758	-	0.010180344	0.9898197
ENST00000221264	ENST00000330387	PLAUR	chr19	44169468	-	CREB3L2	chr7	137600758	-	0.000464582	0.99953544
ENST00000221264	ENST00000456390	PLAUR	chr19	44169468	-	CREB3L2	chr7	137600758	-	0.004868004	0.99513197
ENST00000221264	ENST00000452463	PLAUR	chr19	44169468	-	CREB3L2	chr7	137600758	-	0.009960945	0.99003905
ENST00000221264	ENST00000458726	PLAUR	chr19	44169468	-	CREB3L2	chr7	137600758	-	0.009463705	0.9905363

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Fusion Amino Acid Sequences

For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>65925_65925_1_PLAUR-CREB3L2_PLAUR_chr19_44169468_ENST00000221264_CREB3L2_chr7_137600758_ENST00000330387_length(amino acids)=537AA_BP=123
MRPEGEKTCRDPAHRSCPRDMGHPPLLPLLLLLHTCVPASWGLRCMQCKTNGDCRVEECALGQDLCRTTIVRLWEEGEELELVEKSCTHS
EKTNRTLSYRTGLKITSLTEVVCGLDLCNQGNSDEVESEKWYLSTDFPSTSIKTEPVTDEPPPGLVPSVTLTITAISTPLEKEEPPLEMN
TGVDSSCQTIIPKIKLEPHEVDQFLNFSPKEAPVDHLHLPPTPPSSHGSDSEGSLSPNPRLHPFSLPQTHSPSRAAPRAPSALSSSPLLT
APHKLQGSGPLVLTEEEKRTLIAEGYPIPTKLPLSKSEEKALKKIRRKIKNKISAQESRRKKKEYMDSLEKKVESCSTENLELRKKVEVL
ENTNRTLLQQLQKLQTLVMGKVSRTCKLAGTQTGTCLMVVVLCFAVAFGSFFQGYGPYPSATKMALPSQHSLQEPYTASVVRSRNLLIYE

--------------------------------------------------------------

>65925_65925_2_PLAUR-CREB3L2_PLAUR_chr19_44169468_ENST00000221264_CREB3L2_chr7_137600758_ENST00000452463_length(amino acids)=265AA_BP=123
MRPEGEKTCRDPAHRSCPRDMGHPPLLPLLLLLHTCVPASWGLRCMQCKTNGDCRVEECALGQDLCRTTIVRLWEEGEELELVEKSCTHS
EKTNRTLSYRTGLKITSLTEVVCGLDLCNQGNSDEVESEKWYLSTDFPSTSIKTEPVTDEPPPGLVPSVTLTITAISTPLEKEEPPLEMN

--------------------------------------------------------------

>65925_65925_3_PLAUR-CREB3L2_PLAUR_chr19_44169468_ENST00000221264_CREB3L2_chr7_137600758_ENST00000456390_length(amino acids)=477AA_BP=123
MRPEGEKTCRDPAHRSCPRDMGHPPLLPLLLLLHTCVPASWGLRCMQCKTNGDCRVEECALGQDLCRTTIVRLWEEGEELELVEKSCTHS
EKTNRTLSYRTGLKITSLTEVVCGLDLCNQGNSDEVESEKWYLSTDFPSTSIKTEPVTDEPPPGLVPSVTLTITAISTPLEKEEPPLEMN
TGVDSSCQTIIPKIKLEPHEVDQFLNFSPKEAPVDHLHLPPTPPSSHGSDSEGSLSPNPRLHPFSLPQTHSPSRAAPRAPSALSSSPLLT
APHKLQGSGPLVLTEEEKRTLIAEGYPIPTKLPLSKSEEKALKKIRRKIKNKISAQESRRKKKEYMDSLEKKVESCSTENLELRKKVEVL
ENTNRTLLQQLQKLQTLVMGKVSRTCKLAGTQTGTCLMVVVLCFAVAFGSFFQGYGPYPSATKMALPSQHSLQEPYTASVGKTACGKLGR

--------------------------------------------------------------

>65925_65925_4_PLAUR-CREB3L2_PLAUR_chr19_44169468_ENST00000221264_CREB3L2_chr7_137600758_ENST00000458726_length(amino acids)=265AA_BP=123
MRPEGEKTCRDPAHRSCPRDMGHPPLLPLLLLLHTCVPASWGLRCMQCKTNGDCRVEECALGQDLCRTTIVRLWEEGEELELVEKSCTHS
EKTNRTLSYRTGLKITSLTEVVCGLDLCNQGNSDEVESEKWYLSTDFPSTSIKTEPVTDEPPPGLVPSVTLTITAISTPLEKEEPPLEMN

--------------------------------------------------------------

>65925_65925_5_PLAUR-CREB3L2_PLAUR_chr19_44169468_ENST00000339082_CREB3L2_chr7_137600758_ENST00000330387_length(amino acids)=517AA_BP=103
MGHPPLLPLLLLLHTCVPASWGLRCMQCKTNGDCRVEECALGQDLCRTTIVRLWEEGEELELVEKSCTHSEKTNRTLSYRTGLKITSLTE
VVCGLDLCNQGNSDEVESEKWYLSTDFPSTSIKTEPVTDEPPPGLVPSVTLTITAISTPLEKEEPPLEMNTGVDSSCQTIIPKIKLEPHE
VDQFLNFSPKEAPVDHLHLPPTPPSSHGSDSEGSLSPNPRLHPFSLPQTHSPSRAAPRAPSALSSSPLLTAPHKLQGSGPLVLTEEEKRT
LIAEGYPIPTKLPLSKSEEKALKKIRRKIKNKISAQESRRKKKEYMDSLEKKVESCSTENLELRKKVEVLENTNRTLLQQLQKLQTLVMG
KVSRTCKLAGTQTGTCLMVVVLCFAVAFGSFFQGYGPYPSATKMALPSQHSLQEPYTASVVRSRNLLIYEEHSPPEESSSPGSAGELGGW

--------------------------------------------------------------

>65925_65925_6_PLAUR-CREB3L2_PLAUR_chr19_44169468_ENST00000339082_CREB3L2_chr7_137600758_ENST00000452463_length(amino acids)=245AA_BP=103
MGHPPLLPLLLLLHTCVPASWGLRCMQCKTNGDCRVEECALGQDLCRTTIVRLWEEGEELELVEKSCTHSEKTNRTLSYRTGLKITSLTE
VVCGLDLCNQGNSDEVESEKWYLSTDFPSTSIKTEPVTDEPPPGLVPSVTLTITAISTPLEKEEPPLEMNTGVDSSCQTIIPKIKLEPHE

--------------------------------------------------------------

>65925_65925_7_PLAUR-CREB3L2_PLAUR_chr19_44169468_ENST00000339082_CREB3L2_chr7_137600758_ENST00000456390_length(amino acids)=457AA_BP=103
MGHPPLLPLLLLLHTCVPASWGLRCMQCKTNGDCRVEECALGQDLCRTTIVRLWEEGEELELVEKSCTHSEKTNRTLSYRTGLKITSLTE
VVCGLDLCNQGNSDEVESEKWYLSTDFPSTSIKTEPVTDEPPPGLVPSVTLTITAISTPLEKEEPPLEMNTGVDSSCQTIIPKIKLEPHE
VDQFLNFSPKEAPVDHLHLPPTPPSSHGSDSEGSLSPNPRLHPFSLPQTHSPSRAAPRAPSALSSSPLLTAPHKLQGSGPLVLTEEEKRT
LIAEGYPIPTKLPLSKSEEKALKKIRRKIKNKISAQESRRKKKEYMDSLEKKVESCSTENLELRKKVEVLENTNRTLLQQLQKLQTLVMG
KVSRTCKLAGTQTGTCLMVVVLCFAVAFGSFFQGYGPYPSATKMALPSQHSLQEPYTASVGKTACGKLGRVLFYFPRAGFLSLPKGIFCE

--------------------------------------------------------------

>65925_65925_8_PLAUR-CREB3L2_PLAUR_chr19_44169468_ENST00000339082_CREB3L2_chr7_137600758_ENST00000458726_length(amino acids)=245AA_BP=103
MGHPPLLPLLLLLHTCVPASWGLRCMQCKTNGDCRVEECALGQDLCRTTIVRLWEEGEELELVEKSCTHSEKTNRTLSYRTGLKITSLTE
VVCGLDLCNQGNSDEVESEKWYLSTDFPSTSIKTEPVTDEPPPGLVPSVTLTITAISTPLEKEEPPLEMNTGVDSSCQTIIPKIKLEPHE

--------------------------------------------------------------

>65925_65925_9_PLAUR-CREB3L2_PLAUR_chr19_44169468_ENST00000340093_CREB3L2_chr7_137600758_ENST00000330387_length(amino acids)=537AA_BP=123
MRPEGEKTCRDPAHRSCPRDMGHPPLLPLLLLLHTCVPASWGLRCMQCKTNGDCRVEECALGQDLCRTTIVRLWEEGEELELVEKSCTHS
EKTNRTLSYRTGLKITSLTEVVCGLDLCNQGNSDEVESEKWYLSTDFPSTSIKTEPVTDEPPPGLVPSVTLTITAISTPLEKEEPPLEMN
TGVDSSCQTIIPKIKLEPHEVDQFLNFSPKEAPVDHLHLPPTPPSSHGSDSEGSLSPNPRLHPFSLPQTHSPSRAAPRAPSALSSSPLLT
APHKLQGSGPLVLTEEEKRTLIAEGYPIPTKLPLSKSEEKALKKIRRKIKNKISAQESRRKKKEYMDSLEKKVESCSTENLELRKKVEVL
ENTNRTLLQQLQKLQTLVMGKVSRTCKLAGTQTGTCLMVVVLCFAVAFGSFFQGYGPYPSATKMALPSQHSLQEPYTASVVRSRNLLIYE

--------------------------------------------------------------

>65925_65925_10_PLAUR-CREB3L2_PLAUR_chr19_44169468_ENST00000340093_CREB3L2_chr7_137600758_ENST00000452463_length(amino acids)=265AA_BP=123
MRPEGEKTCRDPAHRSCPRDMGHPPLLPLLLLLHTCVPASWGLRCMQCKTNGDCRVEECALGQDLCRTTIVRLWEEGEELELVEKSCTHS
EKTNRTLSYRTGLKITSLTEVVCGLDLCNQGNSDEVESEKWYLSTDFPSTSIKTEPVTDEPPPGLVPSVTLTITAISTPLEKEEPPLEMN

--------------------------------------------------------------

>65925_65925_11_PLAUR-CREB3L2_PLAUR_chr19_44169468_ENST00000340093_CREB3L2_chr7_137600758_ENST00000456390_length(amino acids)=477AA_BP=123
MRPEGEKTCRDPAHRSCPRDMGHPPLLPLLLLLHTCVPASWGLRCMQCKTNGDCRVEECALGQDLCRTTIVRLWEEGEELELVEKSCTHS
EKTNRTLSYRTGLKITSLTEVVCGLDLCNQGNSDEVESEKWYLSTDFPSTSIKTEPVTDEPPPGLVPSVTLTITAISTPLEKEEPPLEMN
TGVDSSCQTIIPKIKLEPHEVDQFLNFSPKEAPVDHLHLPPTPPSSHGSDSEGSLSPNPRLHPFSLPQTHSPSRAAPRAPSALSSSPLLT
APHKLQGSGPLVLTEEEKRTLIAEGYPIPTKLPLSKSEEKALKKIRRKIKNKISAQESRRKKKEYMDSLEKKVESCSTENLELRKKVEVL
ENTNRTLLQQLQKLQTLVMGKVSRTCKLAGTQTGTCLMVVVLCFAVAFGSFFQGYGPYPSATKMALPSQHSLQEPYTASVGKTACGKLGR

--------------------------------------------------------------

>65925_65925_12_PLAUR-CREB3L2_PLAUR_chr19_44169468_ENST00000340093_CREB3L2_chr7_137600758_ENST00000458726_length(amino acids)=265AA_BP=123
MRPEGEKTCRDPAHRSCPRDMGHPPLLPLLLLLHTCVPASWGLRCMQCKTNGDCRVEECALGQDLCRTTIVRLWEEGEELELVEKSCTHS
EKTNRTLSYRTGLKITSLTEVVCGLDLCNQGNSDEVESEKWYLSTDFPSTSIKTEPVTDEPPPGLVPSVTLTITAISTPLEKEEPPLEMN

--------------------------------------------------------------

>65925_65925_13_PLAUR-CREB3L2_PLAUR_chr19_44169468_ENST00000601723_CREB3L2_chr7_137600758_ENST00000330387_length(amino acids)=517AA_BP=103
MGHPPLLPLLLLLHTCVPASWGLRCMQCKTNGDCRVEECALGQDLCRTTIVRLWEEGEELELVEKSCTHSEKTNRTLSYRTGLKITSLTE
VVCGLDLCNQGNSDEVESEKWYLSTDFPSTSIKTEPVTDEPPPGLVPSVTLTITAISTPLEKEEPPLEMNTGVDSSCQTIIPKIKLEPHE
VDQFLNFSPKEAPVDHLHLPPTPPSSHGSDSEGSLSPNPRLHPFSLPQTHSPSRAAPRAPSALSSSPLLTAPHKLQGSGPLVLTEEEKRT
LIAEGYPIPTKLPLSKSEEKALKKIRRKIKNKISAQESRRKKKEYMDSLEKKVESCSTENLELRKKVEVLENTNRTLLQQLQKLQTLVMG
KVSRTCKLAGTQTGTCLMVVVLCFAVAFGSFFQGYGPYPSATKMALPSQHSLQEPYTASVVRSRNLLIYEEHSPPEESSSPGSAGELGGW

--------------------------------------------------------------

>65925_65925_14_PLAUR-CREB3L2_PLAUR_chr19_44169468_ENST00000601723_CREB3L2_chr7_137600758_ENST00000452463_length(amino acids)=245AA_BP=103
MGHPPLLPLLLLLHTCVPASWGLRCMQCKTNGDCRVEECALGQDLCRTTIVRLWEEGEELELVEKSCTHSEKTNRTLSYRTGLKITSLTE
VVCGLDLCNQGNSDEVESEKWYLSTDFPSTSIKTEPVTDEPPPGLVPSVTLTITAISTPLEKEEPPLEMNTGVDSSCQTIIPKIKLEPHE

--------------------------------------------------------------

>65925_65925_15_PLAUR-CREB3L2_PLAUR_chr19_44169468_ENST00000601723_CREB3L2_chr7_137600758_ENST00000456390_length(amino acids)=457AA_BP=103
MGHPPLLPLLLLLHTCVPASWGLRCMQCKTNGDCRVEECALGQDLCRTTIVRLWEEGEELELVEKSCTHSEKTNRTLSYRTGLKITSLTE
VVCGLDLCNQGNSDEVESEKWYLSTDFPSTSIKTEPVTDEPPPGLVPSVTLTITAISTPLEKEEPPLEMNTGVDSSCQTIIPKIKLEPHE
VDQFLNFSPKEAPVDHLHLPPTPPSSHGSDSEGSLSPNPRLHPFSLPQTHSPSRAAPRAPSALSSSPLLTAPHKLQGSGPLVLTEEEKRT
LIAEGYPIPTKLPLSKSEEKALKKIRRKIKNKISAQESRRKKKEYMDSLEKKVESCSTENLELRKKVEVLENTNRTLLQQLQKLQTLVMG
KVSRTCKLAGTQTGTCLMVVVLCFAVAFGSFFQGYGPYPSATKMALPSQHSLQEPYTASVGKTACGKLGRVLFYFPRAGFLSLPKGIFCE

--------------------------------------------------------------

>65925_65925_16_PLAUR-CREB3L2_PLAUR_chr19_44169468_ENST00000601723_CREB3L2_chr7_137600758_ENST00000458726_length(amino acids)=245AA_BP=103
MGHPPLLPLLLLLHTCVPASWGLRCMQCKTNGDCRVEECALGQDLCRTTIVRLWEEGEELELVEKSCTHSEKTNRTLSYRTGLKITSLTE
VVCGLDLCNQGNSDEVESEKWYLSTDFPSTSIKTEPVTDEPPPGLVPSVTLTITAISTPLEKEEPPLEMNTGVDSSCQTIIPKIKLEPHE

--------------------------------------------------------------

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Fusion Protein Functional Features

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr19:44169468/chr7:137600758)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	CREB3L2 Q70SY1
FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.	FUNCTION: Transcription factor involved in unfolded protein response (UPR). In the absence of endoplasmic reticulum (ER) stress, inserted into ER membranes, with N-terminal DNA-binding and transcription activation domains oriented toward the cytosolic face of the membrane. In response to ER stress, transported to the Golgi, where it is cleaved in a site-specific manner by resident proteases S1P/MBTPS1 and S2P/MBTPS2. The released N-terminal cytosolic domain is translocated to the nucleus to effect transcription of specific target genes. Plays a critical role in chondrogenesis by activating the transcription of SEC23A, which promotes the transport and secretion of cartilage matrix proteins, and possibly that of ER biogenesis-related genes (By similarity). In a neuroblastoma cell line, protects cells from ER stress-induced death (PubMed:17178827). In vitro activates transcription of target genes via direct binding to the CRE site (PubMed:17178827). {ECO:0000250\|UniProtKB:Q8BH52, ECO:0000269\|PubMed:17178827}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
* Minus value of BPloci means that the break pointn is located before the CDS.

- Retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

CREB3L2

chr19:44169468

chr7:137600758

ENST00000330387

294_357

106.33333333333333

521.0

Domain

bZIP

Tgene

CREB3L2

chr19:44169468

chr7:137600758

ENST00000452463

294_357

106.33333333333333

249.0

Domain

bZIP

Tgene

CREB3L2

chr19:44169468

chr7:137600758

ENST00000456390

294_357

106.33333333333333

461.0

Domain

bZIP

Tgene

CREB3L2

chr19:44169468

chr7:137600758

ENST00000330387

427_430

106.33333333333333

521.0

Motif

S1P recognition

Tgene

CREB3L2

chr19:44169468

chr7:137600758

ENST00000452463

427_430

106.33333333333333

249.0

Motif

S1P recognition

Tgene

CREB3L2

chr19:44169468

chr7:137600758

ENST00000456390

427_430

106.33333333333333

461.0

Motif

S1P recognition

Tgene

CREB3L2

chr19:44169468

chr7:137600758

ENST00000330387

296_325

106.33333333333333

521.0

Region

Basic motif

Tgene

CREB3L2

chr19:44169468

chr7:137600758

ENST00000330387

336_357

106.33333333333333

521.0

Region

Leucine-zipper

Tgene

CREB3L2

chr19:44169468

chr7:137600758

ENST00000452463

296_325

106.33333333333333

249.0

Region

Basic motif

Tgene

CREB3L2

chr19:44169468

chr7:137600758

ENST00000452463

336_357

106.33333333333333

249.0

Region

Leucine-zipper

Tgene

CREB3L2

chr19:44169468

chr7:137600758

ENST00000456390

296_325

106.33333333333333

461.0

Region

Basic motif

Tgene

CREB3L2

chr19:44169468

chr7:137600758

ENST00000456390

336_357

106.33333333333333

461.0

Region

Leucine-zipper

Tgene

CREB3L2

chr19:44169468

chr7:137600758

ENST00000330387

401_520

106.33333333333333

521.0

Topological domain

Lumenal

Tgene

CREB3L2

chr19:44169468

chr7:137600758

ENST00000452463

401_520

106.33333333333333

249.0

Topological domain

Lumenal

Tgene

CREB3L2

chr19:44169468

chr7:137600758

ENST00000456390

401_520

106.33333333333333

461.0

Topological domain

Lumenal

Tgene

CREB3L2

chr19:44169468

chr7:137600758

ENST00000330387

380_400

106.33333333333333

521.0

Transmembrane

Helical%3B Signal-anchor for type II membrane protein

Tgene

CREB3L2

chr19:44169468

chr7:137600758

ENST00000452463

380_400

106.33333333333333

249.0

Transmembrane

Helical%3B Signal-anchor for type II membrane protein

Tgene

CREB3L2

chr19:44169468

chr7:137600758

ENST00000456390

380_400

106.33333333333333

461.0

Transmembrane

Helical%3B Signal-anchor for type II membrane protein

- Not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

PLAUR

chr19:44169468

chr7:137600758

ENST00000221264

115_213

103.33333333333333

291.0

Domain

Note=UPAR/Ly6 2

Hgene

PLAUR

chr19:44169468

chr7:137600758

ENST00000221264

214_305

103.33333333333333

291.0

Domain

Note=UPAR/Ly6 3

Hgene

PLAUR

chr19:44169468

chr7:137600758

ENST00000221264

23_114

103.33333333333333

291.0

Domain

Note=UPAR/Ly6 1

Hgene

PLAUR

chr19:44169468

chr7:137600758

ENST00000339082

115_213

103.33333333333333

282.0

Domain

Note=UPAR/Ly6 2

Hgene

PLAUR

chr19:44169468

chr7:137600758

ENST00000339082

214_305

103.33333333333333

282.0

Domain

Note=UPAR/Ly6 3

Hgene

PLAUR

chr19:44169468

chr7:137600758

ENST00000339082

23_114

103.33333333333333

282.0

Domain

Note=UPAR/Ly6 1

Hgene

PLAUR

chr19:44169468

chr7:137600758

ENST00000340093

115_213

103.33333333333333

336.0

Domain

Note=UPAR/Ly6 2

Hgene

PLAUR

chr19:44169468

chr7:137600758

ENST00000340093

214_305

103.33333333333333

336.0

Domain

Note=UPAR/Ly6 3

Hgene

PLAUR

chr19:44169468

chr7:137600758

ENST00000340093

23_114

103.33333333333333

336.0

Domain

Note=UPAR/Ly6 1

Tgene

CREB3L2

chr19:44169468

chr7:137600758

ENST00000330387

1_379

106.33333333333333

521.0

Topological domain

Cytoplasmic

Tgene

CREB3L2

chr19:44169468

chr7:137600758

ENST00000452463

1_379

106.33333333333333

249.0

Topological domain

Cytoplasmic

Tgene

CREB3L2

chr19:44169468

chr7:137600758

ENST00000456390

1_379

106.33333333333333

461.0

Topological domain

Cytoplasmic

Top

Fusion Protein-Protein Interaction

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)

Gene

PPI interactors

Protein-protein interactors based on sequence similarity (STRING)

Gene	STRING network
PLAUR
CREB3L2

- Retained interactions in fusion protein (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost interactions due to fusion (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs to PLAUR-CREB3L2

Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Drug

Source

PMID

Top

Related Diseases to PLAUR-CREB3L2

Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Disease

Source

PMID

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source