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Center for Computational Systems Medicine level1
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:POLE-ANKS1B

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: POLE-ANKS1B
FusionPDB ID: 66932
FusionGDB2.0 ID: 66932
HgeneTgene
Gene symbol

POLE

ANKS1B

Gene ID

5426

56899

Gene nameDNA polymerase epsilon, catalytic subunitankyrin repeat and sterile alpha motif domain containing 1B
SynonymsCRCS12|FILS|IMAGEI|POLE1AIDA|AIDA-1|ANKS2|EB-1|EB1|cajalin-2
Cytomap

12q24.33

12q23.1

Type of geneprotein-codingprotein-coding
DescriptionDNA polymerase epsilon catalytic subunit ADNA polymerase II subunit ADNA polymerase epsilon catalytic subunit proteinpolymerase (DNA directed), epsilon, catalytic subunitpolymerase (DNA) epsilon, catalytic subunitankyrin repeat and sterile alpha motif domain-containing protein 1BE2a-Pbx1-associated proteinamyloid-beta precursor protein intracellular domain associated protein 1cajalin 2
Modification date2020031320200313
UniProtAcc.

Q7Z6G8

Ensembl transtripts involved in fusion geneENST idsENST00000320574, ENST00000535270, 
ENST00000434528, 		ENST00000332712, 
ENST00000333732, ENST00000341752, 
ENST00000546568, ENST00000546960, 
ENST00000549558, ENST00000550693, 
ENST00000547446, ENST00000549025, 
ENST00000549493, ENST00000550833, 
ENST00000329257, ENST00000547010, 
ENST00000547776, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score5 X 6 X 3=9027 X 22 X 9=5346
# samples 628
** MAII scorelog2(6/90*10)=-0.584962500721156
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(28/5346*10)=-4.25496110529811
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: POLE [Title/Abstract] AND ANKS1B [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)POLE(133263840)-ANKS1B(99225914), # samples:3
Anticipated loss of major functional domain due to fusion event.POLE-ANKS1B seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
POLE-ANKS1B seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
POLE-ANKS1B seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
POLE-ANKS1B seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgenePOLE

GO:0006287

base-excision repair, gap-filling

10559260


check buttonFusion gene breakpoints across POLE (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across ANKS1B (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BLCATCGA-CF-A27C-01APOLEchr12

133263840

-ANKS1Bchr12

99225914

-
ChimerDB4BLCATCGA-CF-A27CPOLEchr12

133263839

-ANKS1Bchr12

99225914

-


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000320574POLEchr12133263840-ENST00000547776ANKS1Bchr1299225914-12131061211074317
ENST00000320574POLEchr12133263840-ENST00000329257ANKS1Bchr1299225914-10751061211074318
ENST00000320574POLEchr12133263840-ENST00000547010ANKS1Bchr1299225914-895106121894258
ENST00000535270POLEchr12133263840-ENST00000547776ANKS1Bchr1299225914-118275901043317
ENST00000535270POLEchr12133263840-ENST00000329257ANKS1Bchr1299225914-104475901043317
ENST00000535270POLEchr12133263840-ENST00000547010ANKS1Bchr1299225914-8647590863257
ENST00000320574POLEchr12133263839-ENST00000547776ANKS1Bchr1299225914-12131061211074317
ENST00000320574POLEchr12133263839-ENST00000329257ANKS1Bchr1299225914-10751061211074318
ENST00000320574POLEchr12133263839-ENST00000547010ANKS1Bchr1299225914-895106121894258
ENST00000535270POLEchr12133263839-ENST00000547776ANKS1Bchr1299225914-118275901043317
ENST00000535270POLEchr12133263839-ENST00000329257ANKS1Bchr1299225914-104475901043317
ENST00000535270POLEchr12133263839-ENST00000547010ANKS1Bchr1299225914-8647590863257

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000320574ENST00000547776POLEchr12133263840-ANKS1Bchr1299225914-0.0046506380.99534935
ENST00000320574ENST00000329257POLEchr12133263840-ANKS1Bchr1299225914-0.006175090.99382496
ENST00000320574ENST00000547010POLEchr12133263840-ANKS1Bchr1299225914-0.0065054650.9934946
ENST00000535270ENST00000547776POLEchr12133263840-ANKS1Bchr1299225914-0.0042190450.99578094
ENST00000535270ENST00000329257POLEchr12133263840-ANKS1Bchr1299225914-0.0054437970.9945562
ENST00000535270ENST00000547010POLEchr12133263840-ANKS1Bchr1299225914-0.0073032790.9926967
ENST00000320574ENST00000547776POLEchr12133263839-ANKS1Bchr1299225914-0.0046506380.99534935
ENST00000320574ENST00000329257POLEchr12133263839-ANKS1Bchr1299225914-0.006175090.99382496
ENST00000320574ENST00000547010POLEchr12133263839-ANKS1Bchr1299225914-0.0065054650.9934946
ENST00000535270ENST00000547776POLEchr12133263839-ANKS1Bchr1299225914-0.0042190450.99578094
ENST00000535270ENST00000329257POLEchr12133263839-ANKS1Bchr1299225914-0.0054437970.9945562
ENST00000535270ENST00000547010POLEchr12133263839-ANKS1Bchr1299225914-0.0073032790.9926967

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>66932_66932_1_POLE-ANKS1B_POLE_chr12_133263839_ENST00000320574_ANKS1B_chr12_99225914_ENST00000329257_length(amino acids)=318AA_BP=
MIGHRKRILASLGDRLHDDPPQKPPRSITLREPSGNHTPPQLSPSLSQSTYTTGGSLDVPHIIMQGDARRRRNENYFDDIPRSKLERQMA
QTGDWGEPSITLRPPNEATASTPVQYWQHHPEKLIFQSCDYKAFYLGSMLIKELRGTESTQDACAKMRVMCVKSTEQMKKVPTIILSVSY
KGVKFIDATNKNIIAEHEIRNISCAAQDPEDLSTFAYITKDLKSNHHYCHVFTAFDVNLAYEIILTLGQAFEVAYQLALQARKGGHSSTL

--------------------------------------------------------------

>66932_66932_2_POLE-ANKS1B_POLE_chr12_133263839_ENST00000320574_ANKS1B_chr12_99225914_ENST00000547010_length(amino acids)=258AA_BP=
MIGHRKRILASLGDRLHDDPPQKPPRSITLRTGDWGEPSITLRPPNEATASTPVQYWQHHPEKLIFQSCDYKAFYLGSMLIKELRGTEST
QDACAKMRANCQKSTEQMKKVPTIILSVSYKGVKFIDATNKNIIAEHEIRNISCAAQDPEDLSTFAYITKDLKSNHHYCHVFTAFDVNLA

--------------------------------------------------------------

>66932_66932_3_POLE-ANKS1B_POLE_chr12_133263839_ENST00000320574_ANKS1B_chr12_99225914_ENST00000547776_length(amino acids)=317AA_BP=
MIGHRKRILASLGDRLHDDPPQKPPRSITLREPSGNHTPPQLSPSLSQSTYTTGGSLDVPHIIMQGDARRRRNENYFDDIPRSKLERQMA
QTGDWGEPSITLRPPNEATASTPVQYWQHHPEKLIFQSCDYKAFYLGSMLIKELRGTESTQDACAKMRANCQKSTEQMKKVPTIILSVSY
KGVKFIDATNKNIIAEHEIRNISCAAQDPEDLSTFAYITKDLKSNHHYCHVFTAFDVNLAYEIILTLGQAFEVAYQLALQARKGGHSSTL

--------------------------------------------------------------

>66932_66932_4_POLE-ANKS1B_POLE_chr12_133263839_ENST00000535270_ANKS1B_chr12_99225914_ENST00000329257_length(amino acids)=317AA_BP=
MIGHRKRILASLGDRLHDDPPQKPPRSITLREPSGNHTPPQLSPSLSQSTYTTGGSLDVPHIIMQGDARRRRNENYFDDIPRSKLERQMA
QTGDWGEPSITLRPPNEATASTPVQYWQHHPEKLIFQSCDYKAFYLGSMLIKELRGTESTQDACAKMRVMCVKSTEQMKKVPTIILSVSY
KGVKFIDATNKNIIAEHEIRNISCAAQDPEDLSTFAYITKDLKSNHHYCHVFTAFDVNLAYEIILTLGQAFEVAYQLALQARKGGHSSTL

--------------------------------------------------------------

>66932_66932_5_POLE-ANKS1B_POLE_chr12_133263839_ENST00000535270_ANKS1B_chr12_99225914_ENST00000547010_length(amino acids)=257AA_BP=
MIGHRKRILASLGDRLHDDPPQKPPRSITLRTGDWGEPSITLRPPNEATASTPVQYWQHHPEKLIFQSCDYKAFYLGSMLIKELRGTEST
QDACAKMRANCQKSTEQMKKVPTIILSVSYKGVKFIDATNKNIIAEHEIRNISCAAQDPEDLSTFAYITKDLKSNHHYCHVFTAFDVNLA

--------------------------------------------------------------

>66932_66932_6_POLE-ANKS1B_POLE_chr12_133263839_ENST00000535270_ANKS1B_chr12_99225914_ENST00000547776_length(amino acids)=317AA_BP=
MIGHRKRILASLGDRLHDDPPQKPPRSITLREPSGNHTPPQLSPSLSQSTYTTGGSLDVPHIIMQGDARRRRNENYFDDIPRSKLERQMA
QTGDWGEPSITLRPPNEATASTPVQYWQHHPEKLIFQSCDYKAFYLGSMLIKELRGTESTQDACAKMRANCQKSTEQMKKVPTIILSVSY
KGVKFIDATNKNIIAEHEIRNISCAAQDPEDLSTFAYITKDLKSNHHYCHVFTAFDVNLAYEIILTLGQAFEVAYQLALQARKGGHSSTL

--------------------------------------------------------------

>66932_66932_7_POLE-ANKS1B_POLE_chr12_133263840_ENST00000320574_ANKS1B_chr12_99225914_ENST00000329257_length(amino acids)=318AA_BP=
MIGHRKRILASLGDRLHDDPPQKPPRSITLREPSGNHTPPQLSPSLSQSTYTTGGSLDVPHIIMQGDARRRRNENYFDDIPRSKLERQMA
QTGDWGEPSITLRPPNEATASTPVQYWQHHPEKLIFQSCDYKAFYLGSMLIKELRGTESTQDACAKMRVMCVKSTEQMKKVPTIILSVSY
KGVKFIDATNKNIIAEHEIRNISCAAQDPEDLSTFAYITKDLKSNHHYCHVFTAFDVNLAYEIILTLGQAFEVAYQLALQARKGGHSSTL

--------------------------------------------------------------

>66932_66932_8_POLE-ANKS1B_POLE_chr12_133263840_ENST00000320574_ANKS1B_chr12_99225914_ENST00000547010_length(amino acids)=258AA_BP=
MIGHRKRILASLGDRLHDDPPQKPPRSITLRTGDWGEPSITLRPPNEATASTPVQYWQHHPEKLIFQSCDYKAFYLGSMLIKELRGTEST
QDACAKMRANCQKSTEQMKKVPTIILSVSYKGVKFIDATNKNIIAEHEIRNISCAAQDPEDLSTFAYITKDLKSNHHYCHVFTAFDVNLA

--------------------------------------------------------------

>66932_66932_9_POLE-ANKS1B_POLE_chr12_133263840_ENST00000320574_ANKS1B_chr12_99225914_ENST00000547776_length(amino acids)=317AA_BP=
MIGHRKRILASLGDRLHDDPPQKPPRSITLREPSGNHTPPQLSPSLSQSTYTTGGSLDVPHIIMQGDARRRRNENYFDDIPRSKLERQMA
QTGDWGEPSITLRPPNEATASTPVQYWQHHPEKLIFQSCDYKAFYLGSMLIKELRGTESTQDACAKMRANCQKSTEQMKKVPTIILSVSY
KGVKFIDATNKNIIAEHEIRNISCAAQDPEDLSTFAYITKDLKSNHHYCHVFTAFDVNLAYEIILTLGQAFEVAYQLALQARKGGHSSTL

--------------------------------------------------------------

>66932_66932_10_POLE-ANKS1B_POLE_chr12_133263840_ENST00000535270_ANKS1B_chr12_99225914_ENST00000329257_length(amino acids)=317AA_BP=
MIGHRKRILASLGDRLHDDPPQKPPRSITLREPSGNHTPPQLSPSLSQSTYTTGGSLDVPHIIMQGDARRRRNENYFDDIPRSKLERQMA
QTGDWGEPSITLRPPNEATASTPVQYWQHHPEKLIFQSCDYKAFYLGSMLIKELRGTESTQDACAKMRVMCVKSTEQMKKVPTIILSVSY
KGVKFIDATNKNIIAEHEIRNISCAAQDPEDLSTFAYITKDLKSNHHYCHVFTAFDVNLAYEIILTLGQAFEVAYQLALQARKGGHSSTL

--------------------------------------------------------------

>66932_66932_11_POLE-ANKS1B_POLE_chr12_133263840_ENST00000535270_ANKS1B_chr12_99225914_ENST00000547010_length(amino acids)=257AA_BP=
MIGHRKRILASLGDRLHDDPPQKPPRSITLRTGDWGEPSITLRPPNEATASTPVQYWQHHPEKLIFQSCDYKAFYLGSMLIKELRGTEST
QDACAKMRANCQKSTEQMKKVPTIILSVSYKGVKFIDATNKNIIAEHEIRNISCAAQDPEDLSTFAYITKDLKSNHHYCHVFTAFDVNLA

--------------------------------------------------------------

>66932_66932_12_POLE-ANKS1B_POLE_chr12_133263840_ENST00000535270_ANKS1B_chr12_99225914_ENST00000547776_length(amino acids)=317AA_BP=
MIGHRKRILASLGDRLHDDPPQKPPRSITLREPSGNHTPPQLSPSLSQSTYTTGGSLDVPHIIMQGDARRRRNENYFDDIPRSKLERQMA
QTGDWGEPSITLRPPNEATASTPVQYWQHHPEKLIFQSCDYKAFYLGSMLIKELRGTESTQDACAKMRANCQKSTEQMKKVPTIILSVSY
KGVKFIDATNKNIIAEHEIRNISCAAQDPEDLSTFAYITKDLKSNHHYCHVFTAFDVNLAYEIILTLGQAFEVAYQLALQARKGGHSSTL

--------------------------------------------------------------

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr12:133263840/chr12:99225914)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.ANKS1B

Q7Z6G8

FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Isoform 2 may participate in the regulation of nucleoplasmic coilin protein interactions in neuronal and transformed cells.; FUNCTION: Isoform 3 can regulate global protein synthesis by altering nucleolar numbers. {ECO:0000250, ECO:0000269|PubMed:15347684, ECO:0000269|PubMed:15862129}.; FUNCTION: Isoform 4 may play a role as a modulator of APP processing. Overexpression can down-regulate APP processing.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneANKS1Bchr12:133263839chr12:99225914ENST000003417520101056_12130255.0DomainPID
TgeneANKS1Bchr12:133263839chr12:99225914ENST00000341752010810_8760255.0DomainSAM 1
TgeneANKS1Bchr12:133263839chr12:99225914ENST00000341752010884_9490255.0DomainSAM 2
TgeneANKS1Bchr12:133263839chr12:99225914ENST000005465682111056_1213152.0427.0DomainPID
TgeneANKS1Bchr12:133263839chr12:99225914ENST00000546568211810_876152.0427.0DomainSAM 1
TgeneANKS1Bchr12:133263839chr12:99225914ENST00000546568211884_949152.0427.0DomainSAM 2
TgeneANKS1Bchr12:133263839chr12:99225914ENST000005469602121056_1213152.0461.0DomainPID
TgeneANKS1Bchr12:133263839chr12:99225914ENST00000546960212810_876152.0461.0DomainSAM 1
TgeneANKS1Bchr12:133263839chr12:99225914ENST00000546960212884_949152.0461.0DomainSAM 2
TgeneANKS1Bchr12:133263839chr12:99225914ENST000005470109181056_1213502.0765.0DomainPID
TgeneANKS1Bchr12:133263839chr12:99225914ENST00000547010918810_876502.0765.0DomainSAM 1
TgeneANKS1Bchr12:133263839chr12:99225914ENST00000547010918884_949502.0765.0DomainSAM 2
TgeneANKS1Bchr12:133263839chr12:99225914ENST000005474463121056_1213121.0395.0DomainPID
TgeneANKS1Bchr12:133263839chr12:99225914ENST00000547446312810_876121.0395.0DomainSAM 1
TgeneANKS1Bchr12:133263839chr12:99225914ENST00000547446312884_949121.0395.0DomainSAM 2
TgeneANKS1Bchr12:133263839chr12:99225914ENST0000054777616261056_1213926.01249.0DomainPID
TgeneANKS1Bchr12:133263839chr12:99225914ENST000005490250121056_12130358.0DomainPID
TgeneANKS1Bchr12:133263839chr12:99225914ENST00000549025012810_8760358.0DomainSAM 1
TgeneANKS1Bchr12:133263839chr12:99225914ENST00000549025012884_9490358.0DomainSAM 2
TgeneANKS1Bchr12:133263839chr12:99225914ENST000005494932131056_1213152.0511.0DomainPID
TgeneANKS1Bchr12:133263839chr12:99225914ENST00000549493213810_876152.0511.0DomainSAM 1
TgeneANKS1Bchr12:133263839chr12:99225914ENST00000549493213884_949152.0511.0DomainSAM 2
TgeneANKS1Bchr12:133263839chr12:99225914ENST000005495582111056_1213152.0415.0DomainPID
TgeneANKS1Bchr12:133263839chr12:99225914ENST00000549558211810_876152.0415.0DomainSAM 1
TgeneANKS1Bchr12:133263839chr12:99225914ENST00000549558211884_949152.0415.0DomainSAM 2
TgeneANKS1Bchr12:133263839chr12:99225914ENST000005506932121056_1213152.0451.0DomainPID
TgeneANKS1Bchr12:133263839chr12:99225914ENST00000550693212810_876152.0451.0DomainSAM 1
TgeneANKS1Bchr12:133263839chr12:99225914ENST00000550693212884_949152.0451.0DomainSAM 2
TgeneANKS1Bchr12:133263840chr12:99225914ENST000003417520101056_12130255.0DomainPID
TgeneANKS1Bchr12:133263840chr12:99225914ENST00000341752010810_8760255.0DomainSAM 1
TgeneANKS1Bchr12:133263840chr12:99225914ENST00000341752010884_9490255.0DomainSAM 2
TgeneANKS1Bchr12:133263840chr12:99225914ENST000005465682111056_1213152.0427.0DomainPID
TgeneANKS1Bchr12:133263840chr12:99225914ENST00000546568211810_876152.0427.0DomainSAM 1
TgeneANKS1Bchr12:133263840chr12:99225914ENST00000546568211884_949152.0427.0DomainSAM 2
TgeneANKS1Bchr12:133263840chr12:99225914ENST000005469602121056_1213152.0461.0DomainPID
TgeneANKS1Bchr12:133263840chr12:99225914ENST00000546960212810_876152.0461.0DomainSAM 1
TgeneANKS1Bchr12:133263840chr12:99225914ENST00000546960212884_949152.0461.0DomainSAM 2
TgeneANKS1Bchr12:133263840chr12:99225914ENST000005470109181056_1213502.0765.0DomainPID
TgeneANKS1Bchr12:133263840chr12:99225914ENST00000547010918810_876502.0765.0DomainSAM 1
TgeneANKS1Bchr12:133263840chr12:99225914ENST00000547010918884_949502.0765.0DomainSAM 2
TgeneANKS1Bchr12:133263840chr12:99225914ENST000005474463121056_1213121.0395.0DomainPID
TgeneANKS1Bchr12:133263840chr12:99225914ENST00000547446312810_876121.0395.0DomainSAM 1
TgeneANKS1Bchr12:133263840chr12:99225914ENST00000547446312884_949121.0395.0DomainSAM 2
TgeneANKS1Bchr12:133263840chr12:99225914ENST0000054777616261056_1213926.01249.0DomainPID
TgeneANKS1Bchr12:133263840chr12:99225914ENST000005490250121056_12130358.0DomainPID
TgeneANKS1Bchr12:133263840chr12:99225914ENST00000549025012810_8760358.0DomainSAM 1
TgeneANKS1Bchr12:133263840chr12:99225914ENST00000549025012884_9490358.0DomainSAM 2
TgeneANKS1Bchr12:133263840chr12:99225914ENST000005494932131056_1213152.0511.0DomainPID
TgeneANKS1Bchr12:133263840chr12:99225914ENST00000549493213810_876152.0511.0DomainSAM 1
TgeneANKS1Bchr12:133263840chr12:99225914ENST00000549493213884_949152.0511.0DomainSAM 2
TgeneANKS1Bchr12:133263840chr12:99225914ENST000005495582111056_1213152.0415.0DomainPID
TgeneANKS1Bchr12:133263840chr12:99225914ENST00000549558211810_876152.0415.0DomainSAM 1
TgeneANKS1Bchr12:133263840chr12:99225914ENST00000549558211884_949152.0415.0DomainSAM 2
TgeneANKS1Bchr12:133263840chr12:99225914ENST000005506932121056_1213152.0451.0DomainPID
TgeneANKS1Bchr12:133263840chr12:99225914ENST00000550693212810_876152.0451.0DomainSAM 1
TgeneANKS1Bchr12:133263840chr12:99225914ENST00000550693212884_949152.0451.0DomainSAM 2
TgeneANKS1Bchr12:133263839chr12:99225914ENST00000341752010935_9380255.0MotifNuclear localization signal
TgeneANKS1Bchr12:133263839chr12:99225914ENST00000546568211935_938152.0427.0MotifNuclear localization signal
TgeneANKS1Bchr12:133263839chr12:99225914ENST00000546960212935_938152.0461.0MotifNuclear localization signal
TgeneANKS1Bchr12:133263839chr12:99225914ENST00000547010918935_938502.0765.0MotifNuclear localization signal
TgeneANKS1Bchr12:133263839chr12:99225914ENST00000547446312935_938121.0395.0MotifNuclear localization signal
TgeneANKS1Bchr12:133263839chr12:99225914ENST000005477761626935_938926.01249.0MotifNuclear localization signal
TgeneANKS1Bchr12:133263839chr12:99225914ENST00000549025012935_9380358.0MotifNuclear localization signal
TgeneANKS1Bchr12:133263839chr12:99225914ENST00000549493213935_938152.0511.0MotifNuclear localization signal
TgeneANKS1Bchr12:133263839chr12:99225914ENST00000549558211935_938152.0415.0MotifNuclear localization signal
TgeneANKS1Bchr12:133263839chr12:99225914ENST00000550693212935_938152.0451.0MotifNuclear localization signal
TgeneANKS1Bchr12:133263840chr12:99225914ENST00000341752010935_9380255.0MotifNuclear localization signal
TgeneANKS1Bchr12:133263840chr12:99225914ENST00000546568211935_938152.0427.0MotifNuclear localization signal
TgeneANKS1Bchr12:133263840chr12:99225914ENST00000546960212935_938152.0461.0MotifNuclear localization signal
TgeneANKS1Bchr12:133263840chr12:99225914ENST00000547010918935_938502.0765.0MotifNuclear localization signal
TgeneANKS1Bchr12:133263840chr12:99225914ENST00000547446312935_938121.0395.0MotifNuclear localization signal
TgeneANKS1Bchr12:133263840chr12:99225914ENST000005477761626935_938926.01249.0MotifNuclear localization signal
TgeneANKS1Bchr12:133263840chr12:99225914ENST00000549025012935_9380358.0MotifNuclear localization signal
TgeneANKS1Bchr12:133263840chr12:99225914ENST00000549493213935_938152.0511.0MotifNuclear localization signal
TgeneANKS1Bchr12:133263840chr12:99225914ENST00000549558211935_938152.0415.0MotifNuclear localization signal
TgeneANKS1Bchr12:133263840chr12:99225914ENST00000550693212935_938152.0451.0MotifNuclear localization signal
TgeneANKS1Bchr12:133263839chr12:99225914ENST00000341752010127_1560255.0RepeatNote=ANK 4
TgeneANKS1Bchr12:133263839chr12:99225914ENST00000341752010160_1890255.0RepeatNote=ANK 5
TgeneANKS1Bchr12:133263839chr12:99225914ENST00000341752010193_2220255.0RepeatNote=ANK 6
TgeneANKS1Bchr12:133263839chr12:99225914ENST00000341752010225_2540255.0RepeatNote=ANK 7
TgeneANKS1Bchr12:133263839chr12:99225914ENST000003417520102_310255.0RepeatNote=ANK 1
TgeneANKS1Bchr12:133263839chr12:99225914ENST0000034175201058_870255.0RepeatNote=ANK 2
TgeneANKS1Bchr12:133263839chr12:99225914ENST0000034175201091_1200255.0RepeatNote=ANK 3
TgeneANKS1Bchr12:133263839chr12:99225914ENST00000546568211160_189152.0427.0RepeatNote=ANK 5
TgeneANKS1Bchr12:133263839chr12:99225914ENST00000546568211193_222152.0427.0RepeatNote=ANK 6
TgeneANKS1Bchr12:133263839chr12:99225914ENST00000546568211225_254152.0427.0RepeatNote=ANK 7
TgeneANKS1Bchr12:133263839chr12:99225914ENST00000546960212160_189152.0461.0RepeatNote=ANK 5
TgeneANKS1Bchr12:133263839chr12:99225914ENST00000546960212193_222152.0461.0RepeatNote=ANK 6
TgeneANKS1Bchr12:133263839chr12:99225914ENST00000546960212225_254152.0461.0RepeatNote=ANK 7
TgeneANKS1Bchr12:133263839chr12:99225914ENST00000547446312127_156121.0395.0RepeatNote=ANK 4
TgeneANKS1Bchr12:133263839chr12:99225914ENST00000547446312160_189121.0395.0RepeatNote=ANK 5
TgeneANKS1Bchr12:133263839chr12:99225914ENST00000547446312193_222121.0395.0RepeatNote=ANK 6
TgeneANKS1Bchr12:133263839chr12:99225914ENST00000547446312225_254121.0395.0RepeatNote=ANK 7
TgeneANKS1Bchr12:133263839chr12:99225914ENST00000549025012127_1560358.0RepeatNote=ANK 4
TgeneANKS1Bchr12:133263839chr12:99225914ENST00000549025012160_1890358.0RepeatNote=ANK 5
TgeneANKS1Bchr12:133263839chr12:99225914ENST00000549025012193_2220358.0RepeatNote=ANK 6
TgeneANKS1Bchr12:133263839chr12:99225914ENST00000549025012225_2540358.0RepeatNote=ANK 7
TgeneANKS1Bchr12:133263839chr12:99225914ENST000005490250122_310358.0RepeatNote=ANK 1
TgeneANKS1Bchr12:133263839chr12:99225914ENST0000054902501258_870358.0RepeatNote=ANK 2
TgeneANKS1Bchr12:133263839chr12:99225914ENST0000054902501291_1200358.0RepeatNote=ANK 3
TgeneANKS1Bchr12:133263839chr12:99225914ENST00000549493213160_189152.0511.0RepeatNote=ANK 5
TgeneANKS1Bchr12:133263839chr12:99225914ENST00000549493213193_222152.0511.0RepeatNote=ANK 6
TgeneANKS1Bchr12:133263839chr12:99225914ENST00000549493213225_254152.0511.0RepeatNote=ANK 7
TgeneANKS1Bchr12:133263839chr12:99225914ENST00000549558211160_189152.0415.0RepeatNote=ANK 5
TgeneANKS1Bchr12:133263839chr12:99225914ENST00000549558211193_222152.0415.0RepeatNote=ANK 6
TgeneANKS1Bchr12:133263839chr12:99225914ENST00000549558211225_254152.0415.0RepeatNote=ANK 7
TgeneANKS1Bchr12:133263839chr12:99225914ENST00000550693212160_189152.0451.0RepeatNote=ANK 5
TgeneANKS1Bchr12:133263839chr12:99225914ENST00000550693212193_222152.0451.0RepeatNote=ANK 6
TgeneANKS1Bchr12:133263839chr12:99225914ENST00000550693212225_254152.0451.0RepeatNote=ANK 7
TgeneANKS1Bchr12:133263840chr12:99225914ENST00000341752010127_1560255.0RepeatNote=ANK 4
TgeneANKS1Bchr12:133263840chr12:99225914ENST00000341752010160_1890255.0RepeatNote=ANK 5
TgeneANKS1Bchr12:133263840chr12:99225914ENST00000341752010193_2220255.0RepeatNote=ANK 6
TgeneANKS1Bchr12:133263840chr12:99225914ENST00000341752010225_2540255.0RepeatNote=ANK 7
TgeneANKS1Bchr12:133263840chr12:99225914ENST000003417520102_310255.0RepeatNote=ANK 1
TgeneANKS1Bchr12:133263840chr12:99225914ENST0000034175201058_870255.0RepeatNote=ANK 2
TgeneANKS1Bchr12:133263840chr12:99225914ENST0000034175201091_1200255.0RepeatNote=ANK 3
TgeneANKS1Bchr12:133263840chr12:99225914ENST00000546568211160_189152.0427.0RepeatNote=ANK 5
TgeneANKS1Bchr12:133263840chr12:99225914ENST00000546568211193_222152.0427.0RepeatNote=ANK 6
TgeneANKS1Bchr12:133263840chr12:99225914ENST00000546568211225_254152.0427.0RepeatNote=ANK 7
TgeneANKS1Bchr12:133263840chr12:99225914ENST00000546960212160_189152.0461.0RepeatNote=ANK 5
TgeneANKS1Bchr12:133263840chr12:99225914ENST00000546960212193_222152.0461.0RepeatNote=ANK 6
TgeneANKS1Bchr12:133263840chr12:99225914ENST00000546960212225_254152.0461.0RepeatNote=ANK 7
TgeneANKS1Bchr12:133263840chr12:99225914ENST00000547446312127_156121.0395.0RepeatNote=ANK 4
TgeneANKS1Bchr12:133263840chr12:99225914ENST00000547446312160_189121.0395.0RepeatNote=ANK 5
TgeneANKS1Bchr12:133263840chr12:99225914ENST00000547446312193_222121.0395.0RepeatNote=ANK 6
TgeneANKS1Bchr12:133263840chr12:99225914ENST00000547446312225_254121.0395.0RepeatNote=ANK 7
TgeneANKS1Bchr12:133263840chr12:99225914ENST00000549025012127_1560358.0RepeatNote=ANK 4
TgeneANKS1Bchr12:133263840chr12:99225914ENST00000549025012160_1890358.0RepeatNote=ANK 5
TgeneANKS1Bchr12:133263840chr12:99225914ENST00000549025012193_2220358.0RepeatNote=ANK 6
TgeneANKS1Bchr12:133263840chr12:99225914ENST00000549025012225_2540358.0RepeatNote=ANK 7
TgeneANKS1Bchr12:133263840chr12:99225914ENST000005490250122_310358.0RepeatNote=ANK 1
TgeneANKS1Bchr12:133263840chr12:99225914ENST0000054902501258_870358.0RepeatNote=ANK 2
TgeneANKS1Bchr12:133263840chr12:99225914ENST0000054902501291_1200358.0RepeatNote=ANK 3
TgeneANKS1Bchr12:133263840chr12:99225914ENST00000549493213160_189152.0511.0RepeatNote=ANK 5
TgeneANKS1Bchr12:133263840chr12:99225914ENST00000549493213193_222152.0511.0RepeatNote=ANK 6
TgeneANKS1Bchr12:133263840chr12:99225914ENST00000549493213225_254152.0511.0RepeatNote=ANK 7
TgeneANKS1Bchr12:133263840chr12:99225914ENST00000549558211160_189152.0415.0RepeatNote=ANK 5
TgeneANKS1Bchr12:133263840chr12:99225914ENST00000549558211193_222152.0415.0RepeatNote=ANK 6
TgeneANKS1Bchr12:133263840chr12:99225914ENST00000549558211225_254152.0415.0RepeatNote=ANK 7
TgeneANKS1Bchr12:133263840chr12:99225914ENST00000550693212160_189152.0451.0RepeatNote=ANK 5
TgeneANKS1Bchr12:133263840chr12:99225914ENST00000550693212193_222152.0451.0RepeatNote=ANK 6
TgeneANKS1Bchr12:133263840chr12:99225914ENST00000550693212225_254152.0451.0RepeatNote=ANK 7

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePOLEchr12:133263839chr12:99225914ENST00000320574-1492221_223820.6666666666666682287.0MotifCysB motif
HgenePOLEchr12:133263840chr12:99225914ENST00000320574-1492221_223820.6666666666666682287.0MotifCysB motif
HgenePOLEchr12:133263839chr12:99225914ENST00000320574-1492158_219020.6666666666666682287.0Zinc fingerCysA-type
HgenePOLEchr12:133263840chr12:99225914ENST00000320574-1492158_219020.6666666666666682287.0Zinc fingerCysA-type
TgeneANKS1Bchr12:133263839chr12:99225914ENST000005477761626810_876926.01249.0DomainSAM 1
TgeneANKS1Bchr12:133263839chr12:99225914ENST000005477761626884_949926.01249.0DomainSAM 2
TgeneANKS1Bchr12:133263840chr12:99225914ENST000005477761626810_876926.01249.0DomainSAM 1
TgeneANKS1Bchr12:133263840chr12:99225914ENST000005477761626884_949926.01249.0DomainSAM 2
TgeneANKS1Bchr12:133263839chr12:99225914ENST00000546568211127_156152.0427.0RepeatNote=ANK 4
TgeneANKS1Bchr12:133263839chr12:99225914ENST000005465682112_31152.0427.0RepeatNote=ANK 1
TgeneANKS1Bchr12:133263839chr12:99225914ENST0000054656821158_87152.0427.0RepeatNote=ANK 2
TgeneANKS1Bchr12:133263839chr12:99225914ENST0000054656821191_120152.0427.0RepeatNote=ANK 3
TgeneANKS1Bchr12:133263839chr12:99225914ENST00000546960212127_156152.0461.0RepeatNote=ANK 4
TgeneANKS1Bchr12:133263839chr12:99225914ENST000005469602122_31152.0461.0RepeatNote=ANK 1
TgeneANKS1Bchr12:133263839chr12:99225914ENST0000054696021258_87152.0461.0RepeatNote=ANK 2
TgeneANKS1Bchr12:133263839chr12:99225914ENST0000054696021291_120152.0461.0RepeatNote=ANK 3
TgeneANKS1Bchr12:133263839chr12:99225914ENST00000547010918127_156502.0765.0RepeatNote=ANK 4
TgeneANKS1Bchr12:133263839chr12:99225914ENST00000547010918160_189502.0765.0RepeatNote=ANK 5
TgeneANKS1Bchr12:133263839chr12:99225914ENST00000547010918193_222502.0765.0RepeatNote=ANK 6
TgeneANKS1Bchr12:133263839chr12:99225914ENST00000547010918225_254502.0765.0RepeatNote=ANK 7
TgeneANKS1Bchr12:133263839chr12:99225914ENST000005470109182_31502.0765.0RepeatNote=ANK 1
TgeneANKS1Bchr12:133263839chr12:99225914ENST0000054701091858_87502.0765.0RepeatNote=ANK 2
TgeneANKS1Bchr12:133263839chr12:99225914ENST0000054701091891_120502.0765.0RepeatNote=ANK 3
TgeneANKS1Bchr12:133263839chr12:99225914ENST000005474463122_31121.0395.0RepeatNote=ANK 1
TgeneANKS1Bchr12:133263839chr12:99225914ENST0000054744631258_87121.0395.0RepeatNote=ANK 2
TgeneANKS1Bchr12:133263839chr12:99225914ENST0000054744631291_120121.0395.0RepeatNote=ANK 3
TgeneANKS1Bchr12:133263839chr12:99225914ENST000005477761626127_156926.01249.0RepeatNote=ANK 4
TgeneANKS1Bchr12:133263839chr12:99225914ENST000005477761626160_189926.01249.0RepeatNote=ANK 5
TgeneANKS1Bchr12:133263839chr12:99225914ENST000005477761626193_222926.01249.0RepeatNote=ANK 6
TgeneANKS1Bchr12:133263839chr12:99225914ENST000005477761626225_254926.01249.0RepeatNote=ANK 7
TgeneANKS1Bchr12:133263839chr12:99225914ENST0000054777616262_31926.01249.0RepeatNote=ANK 1
TgeneANKS1Bchr12:133263839chr12:99225914ENST00000547776162658_87926.01249.0RepeatNote=ANK 2
TgeneANKS1Bchr12:133263839chr12:99225914ENST00000547776162691_120926.01249.0RepeatNote=ANK 3
TgeneANKS1Bchr12:133263839chr12:99225914ENST00000549493213127_156152.0511.0RepeatNote=ANK 4
TgeneANKS1Bchr12:133263839chr12:99225914ENST000005494932132_31152.0511.0RepeatNote=ANK 1
TgeneANKS1Bchr12:133263839chr12:99225914ENST0000054949321358_87152.0511.0RepeatNote=ANK 2
TgeneANKS1Bchr12:133263839chr12:99225914ENST0000054949321391_120152.0511.0RepeatNote=ANK 3
TgeneANKS1Bchr12:133263839chr12:99225914ENST00000549558211127_156152.0415.0RepeatNote=ANK 4
TgeneANKS1Bchr12:133263839chr12:99225914ENST000005495582112_31152.0415.0RepeatNote=ANK 1
TgeneANKS1Bchr12:133263839chr12:99225914ENST0000054955821158_87152.0415.0RepeatNote=ANK 2
TgeneANKS1Bchr12:133263839chr12:99225914ENST0000054955821191_120152.0415.0RepeatNote=ANK 3
TgeneANKS1Bchr12:133263839chr12:99225914ENST00000550693212127_156152.0451.0RepeatNote=ANK 4
TgeneANKS1Bchr12:133263839chr12:99225914ENST000005506932122_31152.0451.0RepeatNote=ANK 1
TgeneANKS1Bchr12:133263839chr12:99225914ENST0000055069321258_87152.0451.0RepeatNote=ANK 2
TgeneANKS1Bchr12:133263839chr12:99225914ENST0000055069321291_120152.0451.0RepeatNote=ANK 3
TgeneANKS1Bchr12:133263840chr12:99225914ENST00000546568211127_156152.0427.0RepeatNote=ANK 4
TgeneANKS1Bchr12:133263840chr12:99225914ENST000005465682112_31152.0427.0RepeatNote=ANK 1
TgeneANKS1Bchr12:133263840chr12:99225914ENST0000054656821158_87152.0427.0RepeatNote=ANK 2
TgeneANKS1Bchr12:133263840chr12:99225914ENST0000054656821191_120152.0427.0RepeatNote=ANK 3
TgeneANKS1Bchr12:133263840chr12:99225914ENST00000546960212127_156152.0461.0RepeatNote=ANK 4
TgeneANKS1Bchr12:133263840chr12:99225914ENST000005469602122_31152.0461.0RepeatNote=ANK 1
TgeneANKS1Bchr12:133263840chr12:99225914ENST0000054696021258_87152.0461.0RepeatNote=ANK 2
TgeneANKS1Bchr12:133263840chr12:99225914ENST0000054696021291_120152.0461.0RepeatNote=ANK 3
TgeneANKS1Bchr12:133263840chr12:99225914ENST00000547010918127_156502.0765.0RepeatNote=ANK 4
TgeneANKS1Bchr12:133263840chr12:99225914ENST00000547010918160_189502.0765.0RepeatNote=ANK 5
TgeneANKS1Bchr12:133263840chr12:99225914ENST00000547010918193_222502.0765.0RepeatNote=ANK 6
TgeneANKS1Bchr12:133263840chr12:99225914ENST00000547010918225_254502.0765.0RepeatNote=ANK 7
TgeneANKS1Bchr12:133263840chr12:99225914ENST000005470109182_31502.0765.0RepeatNote=ANK 1
TgeneANKS1Bchr12:133263840chr12:99225914ENST0000054701091858_87502.0765.0RepeatNote=ANK 2
TgeneANKS1Bchr12:133263840chr12:99225914ENST0000054701091891_120502.0765.0RepeatNote=ANK 3
TgeneANKS1Bchr12:133263840chr12:99225914ENST000005474463122_31121.0395.0RepeatNote=ANK 1
TgeneANKS1Bchr12:133263840chr12:99225914ENST0000054744631258_87121.0395.0RepeatNote=ANK 2
TgeneANKS1Bchr12:133263840chr12:99225914ENST0000054744631291_120121.0395.0RepeatNote=ANK 3
TgeneANKS1Bchr12:133263840chr12:99225914ENST000005477761626127_156926.01249.0RepeatNote=ANK 4
TgeneANKS1Bchr12:133263840chr12:99225914ENST000005477761626160_189926.01249.0RepeatNote=ANK 5
TgeneANKS1Bchr12:133263840chr12:99225914ENST000005477761626193_222926.01249.0RepeatNote=ANK 6
TgeneANKS1Bchr12:133263840chr12:99225914ENST000005477761626225_254926.01249.0RepeatNote=ANK 7
TgeneANKS1Bchr12:133263840chr12:99225914ENST0000054777616262_31926.01249.0RepeatNote=ANK 1
TgeneANKS1Bchr12:133263840chr12:99225914ENST00000547776162658_87926.01249.0RepeatNote=ANK 2
TgeneANKS1Bchr12:133263840chr12:99225914ENST00000547776162691_120926.01249.0RepeatNote=ANK 3
TgeneANKS1Bchr12:133263840chr12:99225914ENST00000549493213127_156152.0511.0RepeatNote=ANK 4
TgeneANKS1Bchr12:133263840chr12:99225914ENST000005494932132_31152.0511.0RepeatNote=ANK 1
TgeneANKS1Bchr12:133263840chr12:99225914ENST0000054949321358_87152.0511.0RepeatNote=ANK 2
TgeneANKS1Bchr12:133263840chr12:99225914ENST0000054949321391_120152.0511.0RepeatNote=ANK 3
TgeneANKS1Bchr12:133263840chr12:99225914ENST00000549558211127_156152.0415.0RepeatNote=ANK 4
TgeneANKS1Bchr12:133263840chr12:99225914ENST000005495582112_31152.0415.0RepeatNote=ANK 1
TgeneANKS1Bchr12:133263840chr12:99225914ENST0000054955821158_87152.0415.0RepeatNote=ANK 2
TgeneANKS1Bchr12:133263840chr12:99225914ENST0000054955821191_120152.0415.0RepeatNote=ANK 3
TgeneANKS1Bchr12:133263840chr12:99225914ENST00000550693212127_156152.0451.0RepeatNote=ANK 4
TgeneANKS1Bchr12:133263840chr12:99225914ENST000005506932122_31152.0451.0RepeatNote=ANK 1
TgeneANKS1Bchr12:133263840chr12:99225914ENST0000055069321258_87152.0451.0RepeatNote=ANK 2
TgeneANKS1Bchr12:133263840chr12:99225914ENST0000055069321291_120152.0451.0RepeatNote=ANK 3


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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
POLE
ANKS1B


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to POLE-ANKS1B


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to POLE-ANKS1B


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource