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	Fusion Gene Summary
	Fusion Gene Sample Information
	Fusion ORF Analysis
	Fusion Amino Acid Sequences
	Fusion Protein Functional Features
	Fusion Protein-Protein Interaction
	Related drugs with this fusion protein
	Related disease with this fusion protein

Fusion Protein:PPARG-CDKAL1

Fusion Protein Summary

Fusion gene summary

Fusion partner gene information	Fusion gene name: PPARG-CDKAL1
	FusionPDB ID: 67348
	FusionGDB2.0 ID: 67348
		Hgene	Tgene
	Gene symbol	PPARG	CDKAL1
	Gene ID	5468	54901
	Gene name	peroxisome proliferator activated receptor gamma	CDK5 regulatory subunit associated protein 1 like 1
	Synonyms	CIMT1\|GLM1\|NR1C3\|PPARG1\|PPARG2\|PPARgamma	-
	Cytomap	3p25.2	6p22.3
	Type of gene	protein-coding	protein-coding
	Description	peroxisome proliferator-activated receptor gammaPPAR-gammanuclear receptor subfamily 1 group C member 3peroxisome proliferator-activated nuclear receptor gamma variant 1	threonylcarbamoyladenosine tRNA methylthiotransferasetRNA-t(6)A37 methylthiotransferase
	Modification date	20200329	20200322
	UniProtAcc	P37231	Q5VV42
Ensembl transtripts involved in fusion gene	ENST ids	ENST00000287820, ENST00000309576, ENST00000397010, ENST00000397012, ENST00000397015, ENST00000397026, ENST00000397000, ENST00000539812,	ENST00000476517, ENST00000274695, ENST00000378610, ENST00000378624,
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)	* DoF score	7 X 9 X 5=315	23 X 22 X 8=4048
	# samples	13	30
	** MAII score	log2(13/315*10)=-1.27684020535882 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(30/4048*10)=-3.75417488419843 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)	PubMed: PPARG [Title/Abstract] AND CDKAL1 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)	PPARG(12458653)-CDKAL1(20649524), # samples:2
Anticipated loss of major functional domain due to fusion event.	PPARG-CDKAL1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. PPARG-CDKAL1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. PPARG-CDKAL1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. PPARG-CDKAL1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	PPARG	GO:0000122	negative regulation of transcription by RNA polymerase II	12700342
Hgene	PPARG	GO:0006919	activation of cysteine-type endopeptidase activity involved in apoptotic process	18293083
Hgene	PPARG	GO:0007165	signal transduction	9568716
Hgene	PPARG	GO:0010742	macrophage derived foam cell differentiation	26504087
Hgene	PPARG	GO:0010745	negative regulation of macrophage derived foam cell differentiation	19114110
Hgene	PPARG	GO:0010871	negative regulation of receptor biosynthetic process	12700342
Hgene	PPARG	GO:0010887	negative regulation of cholesterol storage	19114110
Hgene	PPARG	GO:0010891	negative regulation of sequestering of triglyceride	12700342
Hgene	PPARG	GO:0016525	negative regulation of angiogenesis	28566713
Hgene	PPARG	GO:0030224	monocyte differentiation	9568716
Hgene	PPARG	GO:0032526	response to retinoic acid	16239304
Hgene	PPARG	GO:0042953	lipoprotein transport	9568716
Hgene	PPARG	GO:0043537	negative regulation of blood vessel endothelial cell migration	28566713
Hgene	PPARG	GO:0045713	low-density lipoprotein particle receptor biosynthetic process	9568716
Hgene	PPARG	GO:0045944	positive regulation of transcription by RNA polymerase II	9568715\|12700342\|16239304\|17611579
Hgene	PPARG	GO:0048469	cell maturation	9568716
Hgene	PPARG	GO:0048662	negative regulation of smooth muscle cell proliferation	20622039
Hgene	PPARG	GO:0051091	positive regulation of DNA-binding transcription factor activity	18293083
Hgene	PPARG	GO:0061614	pri-miRNA transcription by RNA polymerase II	28566713
Hgene	PPARG	GO:0071404	cellular response to low-density lipoprotein particle stimulus	9568716
Hgene	PPARG	GO:1904706	negative regulation of vascular smooth muscle cell proliferation	28522568

Fusion gene breakpoints across PPARG (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across CDKAL1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

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Fusion Gene Sample Information

Fusion gene information from FusionGDB2.0.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	BLCA	TCGA-DK-A1AD-01A	PPARG	chr3	12458653	+	CDKAL1	chr6	20649524	+

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Fusion ORF Analysis

Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000397010	PPARG	chr3	12458653	+	ENST00000274695	CDKAL1	chr6	20649524	+	4389	1570	384	3023	879
ENST00000397010	PPARG	chr3	12458653	+	ENST00000378624	CDKAL1	chr6	20649524	+	4326	1570	384	2960	858
ENST00000397010	PPARG	chr3	12458653	+	ENST00000378610	CDKAL1	chr6	20649524	+	4389	1570	384	3023	879
ENST00000309576	PPARG	chr3	12458653	+	ENST00000274695	CDKAL1	chr6	20649524	+	4242	1423	237	2876	879
ENST00000309576	PPARG	chr3	12458653	+	ENST00000378624	CDKAL1	chr6	20649524	+	4179	1423	237	2813	858
ENST00000309576	PPARG	chr3	12458653	+	ENST00000378610	CDKAL1	chr6	20649524	+	4242	1423	237	2876	879
ENST00000397015	PPARG	chr3	12458653	+	ENST00000274695	CDKAL1	chr6	20649524	+	4127	1308	122	2761	879
ENST00000397015	PPARG	chr3	12458653	+	ENST00000378624	CDKAL1	chr6	20649524	+	4064	1308	122	2698	858
ENST00000397015	PPARG	chr3	12458653	+	ENST00000378610	CDKAL1	chr6	20649524	+	4127	1308	122	2761	879
ENST00000397012	PPARG	chr3	12458653	+	ENST00000274695	CDKAL1	chr6	20649524	+	4378	1559	373	3012	879
ENST00000397012	PPARG	chr3	12458653	+	ENST00000378624	CDKAL1	chr6	20649524	+	4315	1559	373	2949	858
ENST00000397012	PPARG	chr3	12458653	+	ENST00000378610	CDKAL1	chr6	20649524	+	4378	1559	373	3012	879
ENST00000397026	PPARG	chr3	12458653	+	ENST00000274695	CDKAL1	chr6	20649524	+	4406	1587	383	3040	885
ENST00000397026	PPARG	chr3	12458653	+	ENST00000378624	CDKAL1	chr6	20649524	+	4343	1587	383	2977	864
ENST00000397026	PPARG	chr3	12458653	+	ENST00000378610	CDKAL1	chr6	20649524	+	4406	1587	383	3040	885
ENST00000287820	PPARG	chr3	12458653	+	ENST00000274695	CDKAL1	chr6	20649524	+	4210	1391	121	2844	907
ENST00000287820	PPARG	chr3	12458653	+	ENST00000378624	CDKAL1	chr6	20649524	+	4147	1391	121	2781	886
ENST00000287820	PPARG	chr3	12458653	+	ENST00000378610	CDKAL1	chr6	20649524	+	4210	1391	121	2844	907

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000397010	ENST00000274695	PPARG	chr3	12458653	+	CDKAL1	chr6	20649524	+	0.000340269	0.9996598
ENST00000397010	ENST00000378624	PPARG	chr3	12458653	+	CDKAL1	chr6	20649524	+	0.00033901	0.99966097
ENST00000397010	ENST00000378610	PPARG	chr3	12458653	+	CDKAL1	chr6	20649524	+	0.000340269	0.9996598
ENST00000309576	ENST00000274695	PPARG	chr3	12458653	+	CDKAL1	chr6	20649524	+	0.000399912	0.9996001
ENST00000309576	ENST00000378624	PPARG	chr3	12458653	+	CDKAL1	chr6	20649524	+	0.000400781	0.9995993
ENST00000309576	ENST00000378610	PPARG	chr3	12458653	+	CDKAL1	chr6	20649524	+	0.000399912	0.9996001
ENST00000397015	ENST00000274695	PPARG	chr3	12458653	+	CDKAL1	chr6	20649524	+	0.000389632	0.99961036
ENST00000397015	ENST00000378624	PPARG	chr3	12458653	+	CDKAL1	chr6	20649524	+	0.000391117	0.99960893
ENST00000397015	ENST00000378610	PPARG	chr3	12458653	+	CDKAL1	chr6	20649524	+	0.000389632	0.99961036
ENST00000397012	ENST00000274695	PPARG	chr3	12458653	+	CDKAL1	chr6	20649524	+	0.000287663	0.9997123
ENST00000397012	ENST00000378624	PPARG	chr3	12458653	+	CDKAL1	chr6	20649524	+	0.000282883	0.99971706
ENST00000397012	ENST00000378610	PPARG	chr3	12458653	+	CDKAL1	chr6	20649524	+	0.000287663	0.9997123
ENST00000397026	ENST00000274695	PPARG	chr3	12458653	+	CDKAL1	chr6	20649524	+	0.001193687	0.99880636
ENST00000397026	ENST00000378624	PPARG	chr3	12458653	+	CDKAL1	chr6	20649524	+	0.001196198	0.99880385
ENST00000397026	ENST00000378610	PPARG	chr3	12458653	+	CDKAL1	chr6	20649524	+	0.001193687	0.99880636
ENST00000287820	ENST00000274695	PPARG	chr3	12458653	+	CDKAL1	chr6	20649524	+	0.000560537	0.9994394
ENST00000287820	ENST00000378624	PPARG	chr3	12458653	+	CDKAL1	chr6	20649524	+	0.000704241	0.9992957
ENST00000287820	ENST00000378610	PPARG	chr3	12458653	+	CDKAL1	chr6	20649524	+	0.000560537	0.9994394

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Fusion Amino Acid Sequences

For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>67348_67348_1_PPARG-CDKAL1_PPARG_chr3_12458653_ENST00000287820_CDKAL1_chr6_20649524_ENST00000274695_length(amino acids)=907AA_BP=423
MGETLGDSPIDPESDSFTDTLSANISQEMTMVDTEMPFWPTNFGISSVDLSVMEDHSHSFDIKPFTTVDFSSISTPHYEDIPFTRTDPVV
ADYKYDLKLQEYQSAIKVEPASPPYYSEKTQLYNKPHEEPSNSLMAIECRVCGDKASGFHYGVHACEGCKGFFRRTIRLKLIYDRCDLNC
RIHKKSRNKCQYCRFQKCLAVGMSHNAIRFGRMPQAEKEKLLAEISSDIDQLNPESADLRALAKHLYDSYIKSFPLTKAKARAILTGKTT
DKSPFVIYDMNSLMMGEDKIKFKHITPLQEQSKEVAIRIFQGCQFRSVEAVQEITEYAKSIPGFVNLDLNDQVTLLKYGVHEIIYTMLAS
LMNKDGVLISEGQGFMTREFLKSLRKPFGDFMEPKFEFAVKFNALELDDSDLAIFIAVIILSGENASDADLWLLNSCTVKNPAEDHFRNS
IKKAQEENKKIVLAGCVPQAQPRQDYLKGLSIIGVQQIDRVVEVVEETIKGHSVRLLGQKKDNGRRLGGARLDLPKIRKNPLIEIISINT
GCLNACTYCKTKHARGNLASYPIDELVDRAKQSFQEGVCEIWLTSEDTGAYGRDIGTNLPTLLWKLVEVIPEGAMLRLGMTNPPYILEHL
EEMAKILNHPRVYAFLHIPVQSASDSVLMEMKREYCVADFKRVVDFLKEKVPGITIATDIICGFPGETDQDFQETVKLVEEYKFPSLFIN
QFYPRPGTPAAKMEQVPAQVKKQRTKDLSRVFHSYSPYDHKIGERQQVLVTEESFDSKFYVAHNQFYEQVLVPKNPAFMGKMVEVDIYES
GKHFMKGQPVSDAKVYTPSISKPLAKGEVSGLTKDFRNGLGNQLSSGSHTSAASQCDSASSRMVLPMPRLHQDCALRMSVGLALLGLLFA

--------------------------------------------------------------

>67348_67348_2_PPARG-CDKAL1_PPARG_chr3_12458653_ENST00000287820_CDKAL1_chr6_20649524_ENST00000378610_length(amino acids)=907AA_BP=423
MGETLGDSPIDPESDSFTDTLSANISQEMTMVDTEMPFWPTNFGISSVDLSVMEDHSHSFDIKPFTTVDFSSISTPHYEDIPFTRTDPVV
ADYKYDLKLQEYQSAIKVEPASPPYYSEKTQLYNKPHEEPSNSLMAIECRVCGDKASGFHYGVHACEGCKGFFRRTIRLKLIYDRCDLNC
RIHKKSRNKCQYCRFQKCLAVGMSHNAIRFGRMPQAEKEKLLAEISSDIDQLNPESADLRALAKHLYDSYIKSFPLTKAKARAILTGKTT
DKSPFVIYDMNSLMMGEDKIKFKHITPLQEQSKEVAIRIFQGCQFRSVEAVQEITEYAKSIPGFVNLDLNDQVTLLKYGVHEIIYTMLAS
LMNKDGVLISEGQGFMTREFLKSLRKPFGDFMEPKFEFAVKFNALELDDSDLAIFIAVIILSGENASDADLWLLNSCTVKNPAEDHFRNS
IKKAQEENKKIVLAGCVPQAQPRQDYLKGLSIIGVQQIDRVVEVVEETIKGHSVRLLGQKKDNGRRLGGARLDLPKIRKNPLIEIISINT
GCLNACTYCKTKHARGNLASYPIDELVDRAKQSFQEGVCEIWLTSEDTGAYGRDIGTNLPTLLWKLVEVIPEGAMLRLGMTNPPYILEHL
EEMAKILNHPRVYAFLHIPVQSASDSVLMEMKREYCVADFKRVVDFLKEKVPGITIATDIICGFPGETDQDFQETVKLVEEYKFPSLFIN
QFYPRPGTPAAKMEQVPAQVKKQRTKDLSRVFHSYSPYDHKIGERQQVLVTEESFDSKFYVAHNQFYEQVLVPKNPAFMGKMVEVDIYES
GKHFMKGQPVSDAKVYTPSISKPLAKGEVSGLTKDFRNGLGNQLSSGSHTSAASQCDSASSRMVLPMPRLHQDCALRMSVGLALLGLLFA

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>67348_67348_3_PPARG-CDKAL1_PPARG_chr3_12458653_ENST00000287820_CDKAL1_chr6_20649524_ENST00000378624_length(amino acids)=886AA_BP=423
MGETLGDSPIDPESDSFTDTLSANISQEMTMVDTEMPFWPTNFGISSVDLSVMEDHSHSFDIKPFTTVDFSSISTPHYEDIPFTRTDPVV
ADYKYDLKLQEYQSAIKVEPASPPYYSEKTQLYNKPHEEPSNSLMAIECRVCGDKASGFHYGVHACEGCKGFFRRTIRLKLIYDRCDLNC
RIHKKSRNKCQYCRFQKCLAVGMSHNAIRFGRMPQAEKEKLLAEISSDIDQLNPESADLRALAKHLYDSYIKSFPLTKAKARAILTGKTT
DKSPFVIYDMNSLMMGEDKIKFKHITPLQEQSKEVAIRIFQGCQFRSVEAVQEITEYAKSIPGFVNLDLNDQVTLLKYGVHEIIYTMLAS
LMNKDGVLISEGQGFMTREFLKSLRKPFGDFMEPKFEFAVKFNALELDDSDLAIFIAVIILSGENASDADLWLLNSCTVKNPAEDHFRNS
IKKAQEENKKIVLAGCVPQAQPRQDYLKGLSIIGVQQIDRVVEVVEETIKGHSVRLLGQKKDNGRRLGGARLDLPKIRKNPLIEIISINT
GCLNACTYCKTKHARGNLASYPIDELVDRAKQSFQEGVCEIWLTSEDTGAYGRDIGTNLPTLLWKLVEVIPEGAMLRLGMTNPPYILEHL
EEMAKILNHPRVYAFLHIPVQSASDSVLMEMKREYCVADFKRVVDFLKEKVPGITIATDIICGFPGETDQDFQETVKLVEEYKFPSLFIN
QFYPRPGTPAAKMEQVPAQVIGERQQVLVTEESFDSKFYVAHNQFYEQVLVPKNPAFMGKMVEVDIYESGKHFMKGQPVSDAKVYTPSIS

--------------------------------------------------------------

>67348_67348_4_PPARG-CDKAL1_PPARG_chr3_12458653_ENST00000309576_CDKAL1_chr6_20649524_ENST00000274695_length(amino acids)=879AA_BP=395
MTMVDTEMPFWPTNFGISSVDLSVMEDHSHSFDIKPFTTVDFSSISTPHYEDIPFTRTDPVVADYKYDLKLQEYQSAIKVEPASPPYYSE
KTQLYNKPHEEPSNSLMAIECRVCGDKASGFHYGVHACEGCKGFFRRTIRLKLIYDRCDLNCRIHKKSRNKCQYCRFQKCLAVGMSHNAI
RFGRMPQAEKEKLLAEISSDIDQLNPESADLRALAKHLYDSYIKSFPLTKAKARAILTGKTTDKSPFVIYDMNSLMMGEDKIKFKHITPL
QEQSKEVAIRIFQGCQFRSVEAVQEITEYAKSIPGFVNLDLNDQVTLLKYGVHEIIYTMLASLMNKDGVLISEGQGFMTREFLKSLRKPF
GDFMEPKFEFAVKFNALELDDSDLAIFIAVIILSGENASDADLWLLNSCTVKNPAEDHFRNSIKKAQEENKKIVLAGCVPQAQPRQDYLK
GLSIIGVQQIDRVVEVVEETIKGHSVRLLGQKKDNGRRLGGARLDLPKIRKNPLIEIISINTGCLNACTYCKTKHARGNLASYPIDELVD
RAKQSFQEGVCEIWLTSEDTGAYGRDIGTNLPTLLWKLVEVIPEGAMLRLGMTNPPYILEHLEEMAKILNHPRVYAFLHIPVQSASDSVL
MEMKREYCVADFKRVVDFLKEKVPGITIATDIICGFPGETDQDFQETVKLVEEYKFPSLFINQFYPRPGTPAAKMEQVPAQVKKQRTKDL
SRVFHSYSPYDHKIGERQQVLVTEESFDSKFYVAHNQFYEQVLVPKNPAFMGKMVEVDIYESGKHFMKGQPVSDAKVYTPSISKPLAKGE

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>67348_67348_5_PPARG-CDKAL1_PPARG_chr3_12458653_ENST00000309576_CDKAL1_chr6_20649524_ENST00000378610_length(amino acids)=879AA_BP=395
MTMVDTEMPFWPTNFGISSVDLSVMEDHSHSFDIKPFTTVDFSSISTPHYEDIPFTRTDPVVADYKYDLKLQEYQSAIKVEPASPPYYSE
KTQLYNKPHEEPSNSLMAIECRVCGDKASGFHYGVHACEGCKGFFRRTIRLKLIYDRCDLNCRIHKKSRNKCQYCRFQKCLAVGMSHNAI
RFGRMPQAEKEKLLAEISSDIDQLNPESADLRALAKHLYDSYIKSFPLTKAKARAILTGKTTDKSPFVIYDMNSLMMGEDKIKFKHITPL
QEQSKEVAIRIFQGCQFRSVEAVQEITEYAKSIPGFVNLDLNDQVTLLKYGVHEIIYTMLASLMNKDGVLISEGQGFMTREFLKSLRKPF
GDFMEPKFEFAVKFNALELDDSDLAIFIAVIILSGENASDADLWLLNSCTVKNPAEDHFRNSIKKAQEENKKIVLAGCVPQAQPRQDYLK
GLSIIGVQQIDRVVEVVEETIKGHSVRLLGQKKDNGRRLGGARLDLPKIRKNPLIEIISINTGCLNACTYCKTKHARGNLASYPIDELVD
RAKQSFQEGVCEIWLTSEDTGAYGRDIGTNLPTLLWKLVEVIPEGAMLRLGMTNPPYILEHLEEMAKILNHPRVYAFLHIPVQSASDSVL
MEMKREYCVADFKRVVDFLKEKVPGITIATDIICGFPGETDQDFQETVKLVEEYKFPSLFINQFYPRPGTPAAKMEQVPAQVKKQRTKDL
SRVFHSYSPYDHKIGERQQVLVTEESFDSKFYVAHNQFYEQVLVPKNPAFMGKMVEVDIYESGKHFMKGQPVSDAKVYTPSISKPLAKGE

--------------------------------------------------------------

>67348_67348_6_PPARG-CDKAL1_PPARG_chr3_12458653_ENST00000309576_CDKAL1_chr6_20649524_ENST00000378624_length(amino acids)=858AA_BP=395
MTMVDTEMPFWPTNFGISSVDLSVMEDHSHSFDIKPFTTVDFSSISTPHYEDIPFTRTDPVVADYKYDLKLQEYQSAIKVEPASPPYYSE
KTQLYNKPHEEPSNSLMAIECRVCGDKASGFHYGVHACEGCKGFFRRTIRLKLIYDRCDLNCRIHKKSRNKCQYCRFQKCLAVGMSHNAI
RFGRMPQAEKEKLLAEISSDIDQLNPESADLRALAKHLYDSYIKSFPLTKAKARAILTGKTTDKSPFVIYDMNSLMMGEDKIKFKHITPL
QEQSKEVAIRIFQGCQFRSVEAVQEITEYAKSIPGFVNLDLNDQVTLLKYGVHEIIYTMLASLMNKDGVLISEGQGFMTREFLKSLRKPF
GDFMEPKFEFAVKFNALELDDSDLAIFIAVIILSGENASDADLWLLNSCTVKNPAEDHFRNSIKKAQEENKKIVLAGCVPQAQPRQDYLK
GLSIIGVQQIDRVVEVVEETIKGHSVRLLGQKKDNGRRLGGARLDLPKIRKNPLIEIISINTGCLNACTYCKTKHARGNLASYPIDELVD
RAKQSFQEGVCEIWLTSEDTGAYGRDIGTNLPTLLWKLVEVIPEGAMLRLGMTNPPYILEHLEEMAKILNHPRVYAFLHIPVQSASDSVL
MEMKREYCVADFKRVVDFLKEKVPGITIATDIICGFPGETDQDFQETVKLVEEYKFPSLFINQFYPRPGTPAAKMEQVPAQVIGERQQVL
VTEESFDSKFYVAHNQFYEQVLVPKNPAFMGKMVEVDIYESGKHFMKGQPVSDAKVYTPSISKPLAKGEVSGLTKDFRNGLGNQLSSGSH

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>67348_67348_7_PPARG-CDKAL1_PPARG_chr3_12458653_ENST00000397010_CDKAL1_chr6_20649524_ENST00000274695_length(amino acids)=879AA_BP=395
MTMVDTEMPFWPTNFGISSVDLSVMEDHSHSFDIKPFTTVDFSSISTPHYEDIPFTRTDPVVADYKYDLKLQEYQSAIKVEPASPPYYSE
KTQLYNKPHEEPSNSLMAIECRVCGDKASGFHYGVHACEGCKGFFRRTIRLKLIYDRCDLNCRIHKKSRNKCQYCRFQKCLAVGMSHNAI
RFGRMPQAEKEKLLAEISSDIDQLNPESADLRALAKHLYDSYIKSFPLTKAKARAILTGKTTDKSPFVIYDMNSLMMGEDKIKFKHITPL
QEQSKEVAIRIFQGCQFRSVEAVQEITEYAKSIPGFVNLDLNDQVTLLKYGVHEIIYTMLASLMNKDGVLISEGQGFMTREFLKSLRKPF
GDFMEPKFEFAVKFNALELDDSDLAIFIAVIILSGENASDADLWLLNSCTVKNPAEDHFRNSIKKAQEENKKIVLAGCVPQAQPRQDYLK
GLSIIGVQQIDRVVEVVEETIKGHSVRLLGQKKDNGRRLGGARLDLPKIRKNPLIEIISINTGCLNACTYCKTKHARGNLASYPIDELVD
RAKQSFQEGVCEIWLTSEDTGAYGRDIGTNLPTLLWKLVEVIPEGAMLRLGMTNPPYILEHLEEMAKILNHPRVYAFLHIPVQSASDSVL
MEMKREYCVADFKRVVDFLKEKVPGITIATDIICGFPGETDQDFQETVKLVEEYKFPSLFINQFYPRPGTPAAKMEQVPAQVKKQRTKDL
SRVFHSYSPYDHKIGERQQVLVTEESFDSKFYVAHNQFYEQVLVPKNPAFMGKMVEVDIYESGKHFMKGQPVSDAKVYTPSISKPLAKGE

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>67348_67348_8_PPARG-CDKAL1_PPARG_chr3_12458653_ENST00000397010_CDKAL1_chr6_20649524_ENST00000378610_length(amino acids)=879AA_BP=395
MTMVDTEMPFWPTNFGISSVDLSVMEDHSHSFDIKPFTTVDFSSISTPHYEDIPFTRTDPVVADYKYDLKLQEYQSAIKVEPASPPYYSE
KTQLYNKPHEEPSNSLMAIECRVCGDKASGFHYGVHACEGCKGFFRRTIRLKLIYDRCDLNCRIHKKSRNKCQYCRFQKCLAVGMSHNAI
RFGRMPQAEKEKLLAEISSDIDQLNPESADLRALAKHLYDSYIKSFPLTKAKARAILTGKTTDKSPFVIYDMNSLMMGEDKIKFKHITPL
QEQSKEVAIRIFQGCQFRSVEAVQEITEYAKSIPGFVNLDLNDQVTLLKYGVHEIIYTMLASLMNKDGVLISEGQGFMTREFLKSLRKPF
GDFMEPKFEFAVKFNALELDDSDLAIFIAVIILSGENASDADLWLLNSCTVKNPAEDHFRNSIKKAQEENKKIVLAGCVPQAQPRQDYLK
GLSIIGVQQIDRVVEVVEETIKGHSVRLLGQKKDNGRRLGGARLDLPKIRKNPLIEIISINTGCLNACTYCKTKHARGNLASYPIDELVD
RAKQSFQEGVCEIWLTSEDTGAYGRDIGTNLPTLLWKLVEVIPEGAMLRLGMTNPPYILEHLEEMAKILNHPRVYAFLHIPVQSASDSVL
MEMKREYCVADFKRVVDFLKEKVPGITIATDIICGFPGETDQDFQETVKLVEEYKFPSLFINQFYPRPGTPAAKMEQVPAQVKKQRTKDL
SRVFHSYSPYDHKIGERQQVLVTEESFDSKFYVAHNQFYEQVLVPKNPAFMGKMVEVDIYESGKHFMKGQPVSDAKVYTPSISKPLAKGE

--------------------------------------------------------------

>67348_67348_9_PPARG-CDKAL1_PPARG_chr3_12458653_ENST00000397010_CDKAL1_chr6_20649524_ENST00000378624_length(amino acids)=858AA_BP=395
MTMVDTEMPFWPTNFGISSVDLSVMEDHSHSFDIKPFTTVDFSSISTPHYEDIPFTRTDPVVADYKYDLKLQEYQSAIKVEPASPPYYSE
KTQLYNKPHEEPSNSLMAIECRVCGDKASGFHYGVHACEGCKGFFRRTIRLKLIYDRCDLNCRIHKKSRNKCQYCRFQKCLAVGMSHNAI
RFGRMPQAEKEKLLAEISSDIDQLNPESADLRALAKHLYDSYIKSFPLTKAKARAILTGKTTDKSPFVIYDMNSLMMGEDKIKFKHITPL
QEQSKEVAIRIFQGCQFRSVEAVQEITEYAKSIPGFVNLDLNDQVTLLKYGVHEIIYTMLASLMNKDGVLISEGQGFMTREFLKSLRKPF
GDFMEPKFEFAVKFNALELDDSDLAIFIAVIILSGENASDADLWLLNSCTVKNPAEDHFRNSIKKAQEENKKIVLAGCVPQAQPRQDYLK
GLSIIGVQQIDRVVEVVEETIKGHSVRLLGQKKDNGRRLGGARLDLPKIRKNPLIEIISINTGCLNACTYCKTKHARGNLASYPIDELVD
RAKQSFQEGVCEIWLTSEDTGAYGRDIGTNLPTLLWKLVEVIPEGAMLRLGMTNPPYILEHLEEMAKILNHPRVYAFLHIPVQSASDSVL
MEMKREYCVADFKRVVDFLKEKVPGITIATDIICGFPGETDQDFQETVKLVEEYKFPSLFINQFYPRPGTPAAKMEQVPAQVIGERQQVL
VTEESFDSKFYVAHNQFYEQVLVPKNPAFMGKMVEVDIYESGKHFMKGQPVSDAKVYTPSISKPLAKGEVSGLTKDFRNGLGNQLSSGSH

--------------------------------------------------------------

>67348_67348_10_PPARG-CDKAL1_PPARG_chr3_12458653_ENST00000397012_CDKAL1_chr6_20649524_ENST00000274695_length(amino acids)=879AA_BP=395
MTMVDTEMPFWPTNFGISSVDLSVMEDHSHSFDIKPFTTVDFSSISTPHYEDIPFTRTDPVVADYKYDLKLQEYQSAIKVEPASPPYYSE
KTQLYNKPHEEPSNSLMAIECRVCGDKASGFHYGVHACEGCKGFFRRTIRLKLIYDRCDLNCRIHKKSRNKCQYCRFQKCLAVGMSHNAI
RFGRMPQAEKEKLLAEISSDIDQLNPESADLRALAKHLYDSYIKSFPLTKAKARAILTGKTTDKSPFVIYDMNSLMMGEDKIKFKHITPL
QEQSKEVAIRIFQGCQFRSVEAVQEITEYAKSIPGFVNLDLNDQVTLLKYGVHEIIYTMLASLMNKDGVLISEGQGFMTREFLKSLRKPF
GDFMEPKFEFAVKFNALELDDSDLAIFIAVIILSGENASDADLWLLNSCTVKNPAEDHFRNSIKKAQEENKKIVLAGCVPQAQPRQDYLK
GLSIIGVQQIDRVVEVVEETIKGHSVRLLGQKKDNGRRLGGARLDLPKIRKNPLIEIISINTGCLNACTYCKTKHARGNLASYPIDELVD
RAKQSFQEGVCEIWLTSEDTGAYGRDIGTNLPTLLWKLVEVIPEGAMLRLGMTNPPYILEHLEEMAKILNHPRVYAFLHIPVQSASDSVL
MEMKREYCVADFKRVVDFLKEKVPGITIATDIICGFPGETDQDFQETVKLVEEYKFPSLFINQFYPRPGTPAAKMEQVPAQVKKQRTKDL
SRVFHSYSPYDHKIGERQQVLVTEESFDSKFYVAHNQFYEQVLVPKNPAFMGKMVEVDIYESGKHFMKGQPVSDAKVYTPSISKPLAKGE

--------------------------------------------------------------

>67348_67348_11_PPARG-CDKAL1_PPARG_chr3_12458653_ENST00000397012_CDKAL1_chr6_20649524_ENST00000378610_length(amino acids)=879AA_BP=395
MTMVDTEMPFWPTNFGISSVDLSVMEDHSHSFDIKPFTTVDFSSISTPHYEDIPFTRTDPVVADYKYDLKLQEYQSAIKVEPASPPYYSE
KTQLYNKPHEEPSNSLMAIECRVCGDKASGFHYGVHACEGCKGFFRRTIRLKLIYDRCDLNCRIHKKSRNKCQYCRFQKCLAVGMSHNAI
RFGRMPQAEKEKLLAEISSDIDQLNPESADLRALAKHLYDSYIKSFPLTKAKARAILTGKTTDKSPFVIYDMNSLMMGEDKIKFKHITPL
QEQSKEVAIRIFQGCQFRSVEAVQEITEYAKSIPGFVNLDLNDQVTLLKYGVHEIIYTMLASLMNKDGVLISEGQGFMTREFLKSLRKPF
GDFMEPKFEFAVKFNALELDDSDLAIFIAVIILSGENASDADLWLLNSCTVKNPAEDHFRNSIKKAQEENKKIVLAGCVPQAQPRQDYLK
GLSIIGVQQIDRVVEVVEETIKGHSVRLLGQKKDNGRRLGGARLDLPKIRKNPLIEIISINTGCLNACTYCKTKHARGNLASYPIDELVD
RAKQSFQEGVCEIWLTSEDTGAYGRDIGTNLPTLLWKLVEVIPEGAMLRLGMTNPPYILEHLEEMAKILNHPRVYAFLHIPVQSASDSVL
MEMKREYCVADFKRVVDFLKEKVPGITIATDIICGFPGETDQDFQETVKLVEEYKFPSLFINQFYPRPGTPAAKMEQVPAQVKKQRTKDL
SRVFHSYSPYDHKIGERQQVLVTEESFDSKFYVAHNQFYEQVLVPKNPAFMGKMVEVDIYESGKHFMKGQPVSDAKVYTPSISKPLAKGE

--------------------------------------------------------------

>67348_67348_12_PPARG-CDKAL1_PPARG_chr3_12458653_ENST00000397012_CDKAL1_chr6_20649524_ENST00000378624_length(amino acids)=858AA_BP=395
MTMVDTEMPFWPTNFGISSVDLSVMEDHSHSFDIKPFTTVDFSSISTPHYEDIPFTRTDPVVADYKYDLKLQEYQSAIKVEPASPPYYSE
KTQLYNKPHEEPSNSLMAIECRVCGDKASGFHYGVHACEGCKGFFRRTIRLKLIYDRCDLNCRIHKKSRNKCQYCRFQKCLAVGMSHNAI
RFGRMPQAEKEKLLAEISSDIDQLNPESADLRALAKHLYDSYIKSFPLTKAKARAILTGKTTDKSPFVIYDMNSLMMGEDKIKFKHITPL
QEQSKEVAIRIFQGCQFRSVEAVQEITEYAKSIPGFVNLDLNDQVTLLKYGVHEIIYTMLASLMNKDGVLISEGQGFMTREFLKSLRKPF
GDFMEPKFEFAVKFNALELDDSDLAIFIAVIILSGENASDADLWLLNSCTVKNPAEDHFRNSIKKAQEENKKIVLAGCVPQAQPRQDYLK
GLSIIGVQQIDRVVEVVEETIKGHSVRLLGQKKDNGRRLGGARLDLPKIRKNPLIEIISINTGCLNACTYCKTKHARGNLASYPIDELVD
RAKQSFQEGVCEIWLTSEDTGAYGRDIGTNLPTLLWKLVEVIPEGAMLRLGMTNPPYILEHLEEMAKILNHPRVYAFLHIPVQSASDSVL
MEMKREYCVADFKRVVDFLKEKVPGITIATDIICGFPGETDQDFQETVKLVEEYKFPSLFINQFYPRPGTPAAKMEQVPAQVIGERQQVL
VTEESFDSKFYVAHNQFYEQVLVPKNPAFMGKMVEVDIYESGKHFMKGQPVSDAKVYTPSISKPLAKGEVSGLTKDFRNGLGNQLSSGSH

--------------------------------------------------------------

>67348_67348_13_PPARG-CDKAL1_PPARG_chr3_12458653_ENST00000397015_CDKAL1_chr6_20649524_ENST00000274695_length(amino acids)=879AA_BP=395
MTMVDTEMPFWPTNFGISSVDLSVMEDHSHSFDIKPFTTVDFSSISTPHYEDIPFTRTDPVVADYKYDLKLQEYQSAIKVEPASPPYYSE
KTQLYNKPHEEPSNSLMAIECRVCGDKASGFHYGVHACEGCKGFFRRTIRLKLIYDRCDLNCRIHKKSRNKCQYCRFQKCLAVGMSHNAI
RFGRMPQAEKEKLLAEISSDIDQLNPESADLRALAKHLYDSYIKSFPLTKAKARAILTGKTTDKSPFVIYDMNSLMMGEDKIKFKHITPL
QEQSKEVAIRIFQGCQFRSVEAVQEITEYAKSIPGFVNLDLNDQVTLLKYGVHEIIYTMLASLMNKDGVLISEGQGFMTREFLKSLRKPF
GDFMEPKFEFAVKFNALELDDSDLAIFIAVIILSGENASDADLWLLNSCTVKNPAEDHFRNSIKKAQEENKKIVLAGCVPQAQPRQDYLK
GLSIIGVQQIDRVVEVVEETIKGHSVRLLGQKKDNGRRLGGARLDLPKIRKNPLIEIISINTGCLNACTYCKTKHARGNLASYPIDELVD
RAKQSFQEGVCEIWLTSEDTGAYGRDIGTNLPTLLWKLVEVIPEGAMLRLGMTNPPYILEHLEEMAKILNHPRVYAFLHIPVQSASDSVL
MEMKREYCVADFKRVVDFLKEKVPGITIATDIICGFPGETDQDFQETVKLVEEYKFPSLFINQFYPRPGTPAAKMEQVPAQVKKQRTKDL
SRVFHSYSPYDHKIGERQQVLVTEESFDSKFYVAHNQFYEQVLVPKNPAFMGKMVEVDIYESGKHFMKGQPVSDAKVYTPSISKPLAKGE

--------------------------------------------------------------

>67348_67348_14_PPARG-CDKAL1_PPARG_chr3_12458653_ENST00000397015_CDKAL1_chr6_20649524_ENST00000378610_length(amino acids)=879AA_BP=395
MTMVDTEMPFWPTNFGISSVDLSVMEDHSHSFDIKPFTTVDFSSISTPHYEDIPFTRTDPVVADYKYDLKLQEYQSAIKVEPASPPYYSE
KTQLYNKPHEEPSNSLMAIECRVCGDKASGFHYGVHACEGCKGFFRRTIRLKLIYDRCDLNCRIHKKSRNKCQYCRFQKCLAVGMSHNAI
RFGRMPQAEKEKLLAEISSDIDQLNPESADLRALAKHLYDSYIKSFPLTKAKARAILTGKTTDKSPFVIYDMNSLMMGEDKIKFKHITPL
QEQSKEVAIRIFQGCQFRSVEAVQEITEYAKSIPGFVNLDLNDQVTLLKYGVHEIIYTMLASLMNKDGVLISEGQGFMTREFLKSLRKPF
GDFMEPKFEFAVKFNALELDDSDLAIFIAVIILSGENASDADLWLLNSCTVKNPAEDHFRNSIKKAQEENKKIVLAGCVPQAQPRQDYLK
GLSIIGVQQIDRVVEVVEETIKGHSVRLLGQKKDNGRRLGGARLDLPKIRKNPLIEIISINTGCLNACTYCKTKHARGNLASYPIDELVD
RAKQSFQEGVCEIWLTSEDTGAYGRDIGTNLPTLLWKLVEVIPEGAMLRLGMTNPPYILEHLEEMAKILNHPRVYAFLHIPVQSASDSVL
MEMKREYCVADFKRVVDFLKEKVPGITIATDIICGFPGETDQDFQETVKLVEEYKFPSLFINQFYPRPGTPAAKMEQVPAQVKKQRTKDL
SRVFHSYSPYDHKIGERQQVLVTEESFDSKFYVAHNQFYEQVLVPKNPAFMGKMVEVDIYESGKHFMKGQPVSDAKVYTPSISKPLAKGE

--------------------------------------------------------------

>67348_67348_15_PPARG-CDKAL1_PPARG_chr3_12458653_ENST00000397015_CDKAL1_chr6_20649524_ENST00000378624_length(amino acids)=858AA_BP=395
MTMVDTEMPFWPTNFGISSVDLSVMEDHSHSFDIKPFTTVDFSSISTPHYEDIPFTRTDPVVADYKYDLKLQEYQSAIKVEPASPPYYSE
KTQLYNKPHEEPSNSLMAIECRVCGDKASGFHYGVHACEGCKGFFRRTIRLKLIYDRCDLNCRIHKKSRNKCQYCRFQKCLAVGMSHNAI
RFGRMPQAEKEKLLAEISSDIDQLNPESADLRALAKHLYDSYIKSFPLTKAKARAILTGKTTDKSPFVIYDMNSLMMGEDKIKFKHITPL
QEQSKEVAIRIFQGCQFRSVEAVQEITEYAKSIPGFVNLDLNDQVTLLKYGVHEIIYTMLASLMNKDGVLISEGQGFMTREFLKSLRKPF
GDFMEPKFEFAVKFNALELDDSDLAIFIAVIILSGENASDADLWLLNSCTVKNPAEDHFRNSIKKAQEENKKIVLAGCVPQAQPRQDYLK
GLSIIGVQQIDRVVEVVEETIKGHSVRLLGQKKDNGRRLGGARLDLPKIRKNPLIEIISINTGCLNACTYCKTKHARGNLASYPIDELVD
RAKQSFQEGVCEIWLTSEDTGAYGRDIGTNLPTLLWKLVEVIPEGAMLRLGMTNPPYILEHLEEMAKILNHPRVYAFLHIPVQSASDSVL
MEMKREYCVADFKRVVDFLKEKVPGITIATDIICGFPGETDQDFQETVKLVEEYKFPSLFINQFYPRPGTPAAKMEQVPAQVIGERQQVL
VTEESFDSKFYVAHNQFYEQVLVPKNPAFMGKMVEVDIYESGKHFMKGQPVSDAKVYTPSISKPLAKGEVSGLTKDFRNGLGNQLSSGSH

--------------------------------------------------------------

>67348_67348_16_PPARG-CDKAL1_PPARG_chr3_12458653_ENST00000397026_CDKAL1_chr6_20649524_ENST00000274695_length(amino acids)=885AA_BP=401
MKGFSEMTMVDTEMPFWPTNFGISSVDLSVMEDHSHSFDIKPFTTVDFSSISTPHYEDIPFTRTDPVVADYKYDLKLQEYQSAIKVEPAS
PPYYSEKTQLYNKPHEEPSNSLMAIECRVCGDKASGFHYGVHACEGCKGFFRRTIRLKLIYDRCDLNCRIHKKSRNKCQYCRFQKCLAVG
MSHNAIRFGRMPQAEKEKLLAEISSDIDQLNPESADLRALAKHLYDSYIKSFPLTKAKARAILTGKTTDKSPFVIYDMNSLMMGEDKIKF
KHITPLQEQSKEVAIRIFQGCQFRSVEAVQEITEYAKSIPGFVNLDLNDQVTLLKYGVHEIIYTMLASLMNKDGVLISEGQGFMTREFLK
SLRKPFGDFMEPKFEFAVKFNALELDDSDLAIFIAVIILSGENASDADLWLLNSCTVKNPAEDHFRNSIKKAQEENKKIVLAGCVPQAQP
RQDYLKGLSIIGVQQIDRVVEVVEETIKGHSVRLLGQKKDNGRRLGGARLDLPKIRKNPLIEIISINTGCLNACTYCKTKHARGNLASYP
IDELVDRAKQSFQEGVCEIWLTSEDTGAYGRDIGTNLPTLLWKLVEVIPEGAMLRLGMTNPPYILEHLEEMAKILNHPRVYAFLHIPVQS
ASDSVLMEMKREYCVADFKRVVDFLKEKVPGITIATDIICGFPGETDQDFQETVKLVEEYKFPSLFINQFYPRPGTPAAKMEQVPAQVKK
QRTKDLSRVFHSYSPYDHKIGERQQVLVTEESFDSKFYVAHNQFYEQVLVPKNPAFMGKMVEVDIYESGKHFMKGQPVSDAKVYTPSISK

--------------------------------------------------------------

>67348_67348_17_PPARG-CDKAL1_PPARG_chr3_12458653_ENST00000397026_CDKAL1_chr6_20649524_ENST00000378610_length(amino acids)=885AA_BP=401
MKGFSEMTMVDTEMPFWPTNFGISSVDLSVMEDHSHSFDIKPFTTVDFSSISTPHYEDIPFTRTDPVVADYKYDLKLQEYQSAIKVEPAS
PPYYSEKTQLYNKPHEEPSNSLMAIECRVCGDKASGFHYGVHACEGCKGFFRRTIRLKLIYDRCDLNCRIHKKSRNKCQYCRFQKCLAVG
MSHNAIRFGRMPQAEKEKLLAEISSDIDQLNPESADLRALAKHLYDSYIKSFPLTKAKARAILTGKTTDKSPFVIYDMNSLMMGEDKIKF
KHITPLQEQSKEVAIRIFQGCQFRSVEAVQEITEYAKSIPGFVNLDLNDQVTLLKYGVHEIIYTMLASLMNKDGVLISEGQGFMTREFLK
SLRKPFGDFMEPKFEFAVKFNALELDDSDLAIFIAVIILSGENASDADLWLLNSCTVKNPAEDHFRNSIKKAQEENKKIVLAGCVPQAQP
RQDYLKGLSIIGVQQIDRVVEVVEETIKGHSVRLLGQKKDNGRRLGGARLDLPKIRKNPLIEIISINTGCLNACTYCKTKHARGNLASYP
IDELVDRAKQSFQEGVCEIWLTSEDTGAYGRDIGTNLPTLLWKLVEVIPEGAMLRLGMTNPPYILEHLEEMAKILNHPRVYAFLHIPVQS
ASDSVLMEMKREYCVADFKRVVDFLKEKVPGITIATDIICGFPGETDQDFQETVKLVEEYKFPSLFINQFYPRPGTPAAKMEQVPAQVKK
QRTKDLSRVFHSYSPYDHKIGERQQVLVTEESFDSKFYVAHNQFYEQVLVPKNPAFMGKMVEVDIYESGKHFMKGQPVSDAKVYTPSISK

--------------------------------------------------------------

>67348_67348_18_PPARG-CDKAL1_PPARG_chr3_12458653_ENST00000397026_CDKAL1_chr6_20649524_ENST00000378624_length(amino acids)=864AA_BP=401
MKGFSEMTMVDTEMPFWPTNFGISSVDLSVMEDHSHSFDIKPFTTVDFSSISTPHYEDIPFTRTDPVVADYKYDLKLQEYQSAIKVEPAS
PPYYSEKTQLYNKPHEEPSNSLMAIECRVCGDKASGFHYGVHACEGCKGFFRRTIRLKLIYDRCDLNCRIHKKSRNKCQYCRFQKCLAVG
MSHNAIRFGRMPQAEKEKLLAEISSDIDQLNPESADLRALAKHLYDSYIKSFPLTKAKARAILTGKTTDKSPFVIYDMNSLMMGEDKIKF
KHITPLQEQSKEVAIRIFQGCQFRSVEAVQEITEYAKSIPGFVNLDLNDQVTLLKYGVHEIIYTMLASLMNKDGVLISEGQGFMTREFLK
SLRKPFGDFMEPKFEFAVKFNALELDDSDLAIFIAVIILSGENASDADLWLLNSCTVKNPAEDHFRNSIKKAQEENKKIVLAGCVPQAQP
RQDYLKGLSIIGVQQIDRVVEVVEETIKGHSVRLLGQKKDNGRRLGGARLDLPKIRKNPLIEIISINTGCLNACTYCKTKHARGNLASYP
IDELVDRAKQSFQEGVCEIWLTSEDTGAYGRDIGTNLPTLLWKLVEVIPEGAMLRLGMTNPPYILEHLEEMAKILNHPRVYAFLHIPVQS
ASDSVLMEMKREYCVADFKRVVDFLKEKVPGITIATDIICGFPGETDQDFQETVKLVEEYKFPSLFINQFYPRPGTPAAKMEQVPAQVIG
ERQQVLVTEESFDSKFYVAHNQFYEQVLVPKNPAFMGKMVEVDIYESGKHFMKGQPVSDAKVYTPSISKPLAKGEVSGLTKDFRNGLGNQ

--------------------------------------------------------------

Top

Fusion Protein Functional Features

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr3:12458653/chr6:20649524)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
PPARG P37231	CDKAL1 Q5VV42
FUNCTION: Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut homeostasis by suppressing NF-kappa-B-mediated proinflammatory responses. Plays a role in the regulation of cardiovascular circadian rhythms by regulating the transcription of ARNTL/BMAL1 in the blood vessels (By similarity). {ECO:0000250\|UniProtKB:P37238, ECO:0000269\|PubMed:16150867, ECO:0000269\|PubMed:20829347, ECO:0000269\|PubMed:23525231, ECO:0000269\|PubMed:9065481}.; FUNCTION: (Microbial infection) Upon treatment with M.tuberculosis or its lipoprotein LpqH, phosphorylation of MAPK p38 and IL-6 production are modulated, probably via this protein. {ECO:0000269\|PubMed:25504154}.	FUNCTION: Catalyzes the methylthiolation of N6-threonylcarbamoyladenosine (t(6)A), leading to the formation of 2-methylthio-N6-threonylcarbamoyladenosine (ms(2)t(6)A) at position 37 in tRNAs that read codons beginning with adenine. {ECO:0000250\|UniProtKB:Q91WE6}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
* Minus value of BPloci means that the break pointn is located before the CDS.

- Retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

PPARG

chr3:12458653

chr6:20649524

ENST00000287820

136_210

423.3333333333333

506.0

DNA binding

Nuclear receptor

Hgene

PPARG

chr3:12458653

chr6:20649524

ENST00000309576

136_210

395.3333333333333

478.0

DNA binding

Nuclear receptor

Hgene

PPARG

chr3:12458653

chr6:20649524

ENST00000397010

136_210

395.3333333333333

478.0

DNA binding

Nuclear receptor

Hgene

PPARG

chr3:12458653

chr6:20649524

ENST00000397012

136_210

395.3333333333333

478.0

DNA binding

Nuclear receptor

Hgene

PPARG

chr3:12458653

chr6:20649524

ENST00000397015

136_210

395.3333333333333

478.0

DNA binding

Nuclear receptor

Hgene

PPARG

chr3:12458653

chr6:20649524

ENST00000287820

139_159

423.3333333333333

506.0

Zinc finger

NR C4-type

Hgene

PPARG

chr3:12458653

chr6:20649524

ENST00000287820

176_198

423.3333333333333

506.0

Zinc finger

NR C4-type

Hgene

PPARG

chr3:12458653

chr6:20649524

ENST00000309576

139_159

395.3333333333333

478.0

Zinc finger

NR C4-type

Hgene

PPARG

chr3:12458653

chr6:20649524

ENST00000309576

176_198

395.3333333333333

478.0

Zinc finger

NR C4-type

Hgene

PPARG

chr3:12458653

chr6:20649524

ENST00000397010

139_159

395.3333333333333

478.0

Zinc finger

NR C4-type

Hgene

PPARG

chr3:12458653

chr6:20649524

ENST00000397010

176_198

395.3333333333333

478.0

Zinc finger

NR C4-type

Hgene

PPARG

chr3:12458653

chr6:20649524

ENST00000397012

139_159

395.3333333333333

478.0

Zinc finger

NR C4-type

Hgene

PPARG

chr3:12458653

chr6:20649524

ENST00000397012

176_198

395.3333333333333

478.0

Zinc finger

NR C4-type

Hgene

PPARG

chr3:12458653

chr6:20649524

ENST00000397015

139_159

395.3333333333333

478.0

Zinc finger

NR C4-type

Hgene

PPARG

chr3:12458653

chr6:20649524

ENST00000397015

176_198

395.3333333333333

478.0

Zinc finger

NR C4-type

Tgene

CDKAL1

chr3:12458653

chr6:20649524

ENST00000274695

200_431

95.33333333333333

580.0

Domain

Radical SAM core

Tgene

CDKAL1

chr3:12458653

chr6:20649524

ENST00000274695

431_493

95.33333333333333

580.0

Domain

TRAM

Tgene

CDKAL1

chr3:12458653

chr6:20649524

ENST00000378610

200_431

95.33333333333333

580.0

Domain

Radical SAM core

Tgene

CDKAL1

chr3:12458653

chr6:20649524

ENST00000378610

431_493

95.33333333333333

580.0

Domain

TRAM

Tgene

CDKAL1

chr3:12458653

chr6:20649524

ENST00000378624

200_431

25.333333333333332

489.0

Domain

Radical SAM core

Tgene

CDKAL1

chr3:12458653

chr6:20649524

ENST00000378624

431_493

25.333333333333332

489.0

Domain

TRAM

Tgene

CDKAL1

chr3:12458653

chr6:20649524

ENST00000378624

64_172

25.333333333333332

489.0

Domain

MTTase N-terminal

Tgene

CDKAL1

chr3:12458653

chr6:20649524

ENST00000274695

556_578

95.33333333333333

580.0

Transmembrane

Helical

Tgene

CDKAL1

chr3:12458653

chr6:20649524

ENST00000378610

556_578

95.33333333333333

580.0

Transmembrane

Helical

Tgene

CDKAL1

chr3:12458653

chr6:20649524

ENST00000378624

556_578

25.333333333333332

489.0

Transmembrane

Helical

- Not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

PPARG

chr3:12458653

chr6:20649524

ENST00000287820

238_503

423.3333333333333

506.0

Domain

NR LBD

Hgene

PPARG

chr3:12458653

chr6:20649524

ENST00000309576

238_503

395.3333333333333

478.0

Domain

NR LBD

Hgene

PPARG

chr3:12458653

chr6:20649524

ENST00000397010

238_503

395.3333333333333

478.0

Domain

NR LBD

Hgene

PPARG

chr3:12458653

chr6:20649524

ENST00000397012

238_503

395.3333333333333

478.0

Domain

NR LBD

Hgene

PPARG

chr3:12458653

chr6:20649524

ENST00000397015

238_503

395.3333333333333

478.0

Domain

NR LBD

Hgene

PPARG

chr3:12458653

chr6:20649524

ENST00000287820

495_503

423.3333333333333

506.0

Motif

9aaTAD

Hgene

PPARG

chr3:12458653

chr6:20649524

ENST00000309576

495_503

395.3333333333333

478.0

Motif

9aaTAD

Hgene

PPARG

chr3:12458653

chr6:20649524

ENST00000397010

495_503

395.3333333333333

478.0

Motif

9aaTAD

Hgene

PPARG

chr3:12458653

chr6:20649524

ENST00000397012

495_503

395.3333333333333

478.0

Motif

9aaTAD

Hgene

PPARG

chr3:12458653

chr6:20649524

ENST00000397015

495_503

395.3333333333333

478.0

Motif

9aaTAD

Tgene

CDKAL1

chr3:12458653

chr6:20649524

ENST00000274695

64_172

95.33333333333333

580.0

Domain

MTTase N-terminal

Tgene

CDKAL1

chr3:12458653

chr6:20649524

ENST00000378610

64_172

95.33333333333333

580.0

Domain

MTTase N-terminal

Top

Fusion Protein-Protein Interaction

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)

Gene

PPI interactors

PPARG

NCOA4, GADD45G, Gadd45b, DNTTIP2, PPARGC1A, HDAC3, HDAC4, RB1, EP300, EDF1, FABP1, NR0B2, SVIL, NRIP1, POU1F1, CREBBP, RXRA, MED24, MSX2, PML, ZBTB5, NR2E3, MAFF, ZBTB20, ZBTB3, ZNF496, ZBTB9, ZSCAN1, PIAS1, NCOR1, NCOR2, HMGA1, SP1, TFAP2A, CEBPB, MED1, ZNHIT3, TRIP4, JMJD1C, NFKBIB, SERPINH1, NCOA1, TRIM24, NCOA2, NCOA3, GRIP1, KAT5, LRIF1, HDAC1, MECP2, EZH2, NCOA6, NR0B1, COPS5, FHOD1, KIF1A, RXRB, ROBO4, KLF4, KDM4C, TNP1, KCTD13, RAD54L2, ANP32A, APP, RELA, UBC, CDC34, JAZF1, MED14, BCAS2, NEDD4, Rxra, SMARCD3, SMARCA4, CDK5, MIF4GD, USP7, ALOX15B, NR3C1, MUC1, NSD1, PAXIP1, ASH2L, RBBP5, PRKAA1, PRKAA2, CTNNB1, SFPQ, NR4A1, NR4A2, JUN, NFE2L3, PHB2, STAT5A, VDR, RXRG, MAP2K1, CAV1, SMAD3, PDIA2, PPM1B, Foxo1, daf-12, XRCC6, XRCC5, MAPK1, RANBP3, XPO1, Ncor1, JUND, LMO4, RFX5, CIITA, TCF4, NFKB1, PPARG, PRKCA, PIN1, STAT6, IKBKB, KAT2A, KIF11, CEP350, UBE2I, KLF5, IGFBP3, EGFR, MDM2, YWHAB, YWHAG, PPARGC1B, STAT1, STUB1, Pparg, FLYWCH2, PAK4, TNIP2, MFHAS1, TP53, VIMP, SELK, SIRT1, Smurf1, HSPA8, BAG2, RPS3, HNRNPM, HNRNPH1, TUFM, CCT3, DDX17, HSPA1B, TCP1, VCP, BAG5, DHX9, PGAM1, ATP5O, PGD, RUVBL1, RUVBL2, HSPA9, HSPA5, LCP1, CCT8, PPEF2, LGALS7, MRE11A, TOP2B, NAT10, TLN1, RPA2, LIG3, VPS29, RPS8, PBRM1, ZC3HAV1, KHSRP, GIGYF2, MCM7, HSPA6, TRIM28, HEATR1, LRPPRC, RPL10A, SAFB2, SF3B3, NOP14, RPL7A, RPL9, GTF2I, DNAJC7, EFTUD2, DDX18, SH3BGRL, DDX58, HNRNPK, DNAJA3, NUP93, NBN, PSMD11, ILF3, RAD50, SMARCA5, U2SURP, RSL1D1, PSMC1, NOP2, DDX52, UTP14A, ARPC2, ILF2, RPS4X, GTPBP4, H2AFY, DSP, NOP58, POF1B, LGALS3, GNL3, MSN, S100A9, HSP90AA1, DNAJA1, ARPC5, POLR1C, RRP9, UBR5, ATMIN, PROX1, SRSF1, NR1H3, NR1H2, Ppargc1a, MAPK9, ADCY4, GATA5, RARA, TRIM37, ESRRA, TRIM63, VHL, TRIM13, C6orf106, TRIM27, TRIB3, HDAC9, KMT2D, KDM6A, HIVEP1, SMARCA2, KMT2C, KAT2B, SMARCC1, SMARCD1, ZNF536, TBL1X, TADA2A, TADA3, NDUFA8, MLLT6, GPS2, BCL7A, ARID2, ZZZ3, ARID1B, KDM2B, DPF1, DPF2, TBL1XR1, CSRP2BP, BRD9, BRD7, MBIP, GLTSCR1, TRPS1,

Protein-protein interactors based on sequence similarity (STRING)

Gene	STRING network
PPARG
CDKAL1

- Retained interactions in fusion protein (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost interactions due to fusion (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs to PPARG-CDKAL1

Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Drug

Source

PMID

Top

Related Diseases to PPARG-CDKAL1

Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Disease

Source

PMID

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner	Gene	Disease ID	Disease name	# pubmeds	Source
Hgene	PPARG	C0011860	Diabetes Mellitus, Non-Insulin-Dependent	6	CTD_human;GENOMICS_ENGLAND
Hgene	PPARG	C0238463	Papillary thyroid carcinoma	4	ORPHANET
Hgene	PPARG	C0002152	Alloxan Diabetes	3	CTD_human
Hgene	PPARG	C0002395	Alzheimer's Disease	3	CTD_human
Hgene	PPARG	C0011265	Presenile dementia	3	CTD_human
Hgene	PPARG	C0011853	Diabetes Mellitus, Experimental	3	CTD_human
Hgene	PPARG	C0020538	Hypertensive disease	3	CTD_human
Hgene	PPARG	C0021655	Insulin Resistance	3	CTD_human
Hgene	PPARG	C0022660	Kidney Failure, Acute	3	CTD_human
Hgene	PPARG	C0028754	Obesity	3	CTD_human;GENOMICS_ENGLAND;UNIPROT
Hgene	PPARG	C0035126	Reperfusion Injury	3	CTD_human
Hgene	PPARG	C0038433	Streptozotocin Diabetes	3	CTD_human
Hgene	PPARG	C0276496	Familial Alzheimer Disease (FAD)	3	CTD_human
Hgene	PPARG	C0494463	Alzheimer Disease, Late Onset	3	CTD_human
Hgene	PPARG	C0546126	Acute Confusional Senile Dementia	3	CTD_human
Hgene	PPARG	C0750900	Alzheimer's Disease, Focal Onset	3	CTD_human
Hgene	PPARG	C0750901	Alzheimer Disease, Early Onset	3	CTD_human
Hgene	PPARG	C0920563	Insulin Sensitivity	3	CTD_human
Hgene	PPARG	C1565662	Acute Kidney Insufficiency	3	CTD_human
Hgene	PPARG	C1720861	Familial Partial Lipodystrophy, Type 3	3	CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT
Hgene	PPARG	C2609414	Acute kidney injury	3	CTD_human
Hgene	PPARG	C0021368	Inflammation	2	CTD_human
Hgene	PPARG	C0022116	Ischemia	2	CTD_human
Hgene	PPARG	C0024623	Malignant neoplasm of stomach	2	CTD_human
Hgene	PPARG	C0025202	melanoma	2	CTD_human
Hgene	PPARG	C0030297	Pancreatic Neoplasm	2	CTD_human
Hgene	PPARG	C0038356	Stomach Neoplasms	2	CTD_human
Hgene	PPARG	C0346647	Malignant neoplasm of pancreas	2	CTD_human
Hgene	PPARG	C1708349	Hereditary Diffuse Gastric Cancer	2	CTD_human
Hgene	PPARG	C0001418	Adenocarcinoma	1	CTD_human
Hgene	PPARG	C0004153	Atherosclerosis	1	CTD_human
Hgene	PPARG	C0004763	Barrett Esophagus	1	CTD_human
Hgene	PPARG	C0007102	Malignant tumor of colon	1	CTD_human;UNIPROT
Hgene	PPARG	C0009375	Colonic Neoplasms	1	CTD_human
Hgene	PPARG	C0009402	Colorectal Carcinoma	1	CTD_human
Hgene	PPARG	C0009404	Colorectal Neoplasms	1	CTD_human
Hgene	PPARG	C0010346	Crohn Disease	1	CTD_human
Hgene	PPARG	C0011849	Diabetes Mellitus	1	CTD_human
Hgene	PPARG	C0011859	Lipoatrophic Diabetes Mellitus	1	ORPHANET
Hgene	PPARG	C0011881	Diabetic Nephropathy	1	CTD_human
Hgene	PPARG	C0017658	Glomerulonephritis	1	CTD_human
Hgene	PPARG	C0017667	Nodular glomerulosclerosis	1	CTD_human
Hgene	PPARG	C0018801	Heart failure	1	CTD_human
Hgene	PPARG	C0018802	Congestive heart failure	1	CTD_human
Hgene	PPARG	C0023212	Left-Sided Heart Failure	1	CTD_human
Hgene	PPARG	C0023645	Lichen planus follicularis	1	GENOMICS_ENGLAND
Hgene	PPARG	C0023794	Lipoidosis	1	CTD_human
Hgene	PPARG	C0023903	Liver neoplasms	1	CTD_human
Hgene	PPARG	C0025517	Metabolic Diseases	1	CTD_human
Hgene	PPARG	C0027746	Nerve Degeneration	1	CTD_human
Hgene	PPARG	C0029408	Degenerative polyarthritis	1	CTD_human
Hgene	PPARG	C0030246	Pustulosis of Palms and Soles	1	CTD_human
Hgene	PPARG	C0030625	Passive Cutaneous Anaphylaxis	1	GENOMICS_ENGLAND
Hgene	PPARG	C0033860	Psoriasis	1	CTD_human
Hgene	PPARG	C0035078	Kidney Failure	1	CTD_human
Hgene	PPARG	C0038525	Subarachnoid Hemorrhage	1	CTD_human
Hgene	PPARG	C0040136	Thyroid Neoplasm	1	CTD_human
Hgene	PPARG	C0079772	T-Cell Lymphoma	1	CTD_human
Hgene	PPARG	C0085278	Antiphospholipid Syndrome	1	CTD_human
Hgene	PPARG	C0085413	Polycystic Kidney, Autosomal Dominant	1	CTD_human
Hgene	PPARG	C0086743	Osteoarthrosis Deformans	1	CTD_human
Hgene	PPARG	C0086873	Pseudopelade	1	GENOMICS_ENGLAND
Hgene	PPARG	C0151468	Thyroid Gland Follicular Adenoma	1	CTD_human
Hgene	PPARG	C0156147	Crohn's disease of large bowel	1	CTD_human
Hgene	PPARG	C0205641	Adenocarcinoma, Basal Cell	1	CTD_human
Hgene	PPARG	C0205642	Adenocarcinoma, Oxyphilic	1	CTD_human
Hgene	PPARG	C0205643	Carcinoma, Cribriform	1	CTD_human
Hgene	PPARG	C0205644	Carcinoma, Granular Cell	1	CTD_human
Hgene	PPARG	C0205645	Adenocarcinoma, Tubular	1	CTD_human
Hgene	PPARG	C0206726	gliosarcoma	1	ORPHANET
Hgene	PPARG	C0221032	Familial generalized lipodystrophy	1	ORPHANET
Hgene	PPARG	C0221406	Pituitary-dependent Cushing's disease	1	CTD_human
Hgene	PPARG	C0235527	Heart Failure, Right-Sided	1	CTD_human
Hgene	PPARG	C0236811	Chronobiology Disorders	1	CTD_human
Hgene	PPARG	C0242339	Dyslipidemias	1	CTD_human
Hgene	PPARG	C0242488	Acute Lung Injury	1	CTD_human
Hgene	PPARG	C0267380	Crohn's disease of the ileum	1	CTD_human
Hgene	PPARG	C0270192	Perinatal Subarachnoid Hemorrhage	1	CTD_human
Hgene	PPARG	C0271694	Familial partial lipodystrophy	1	CTD_human
Hgene	PPARG	C0282548	Leukostasis	1	CTD_human
Hgene	PPARG	C0334588	Giant Cell Glioblastoma	1	ORPHANET
Hgene	PPARG	C0345904	Malignant neoplasm of liver	1	CTD_human
Hgene	PPARG	C0472383	Subarachnoid Hemorrhage, Spontaneous	1	CTD_human
Hgene	PPARG	C0525045	Mood Disorders	1	PSYGENET
Hgene	PPARG	C0549473	Thyroid carcinoma	1	CTD_human
Hgene	PPARG	C0598784	Dyslipoproteinemias	1	CTD_human
Hgene	PPARG	C0678202	Regional enteritis	1	CTD_human
Hgene	PPARG	C0751220	Inappropriate ACTH Secretion Syndrome	1	CTD_human
Hgene	PPARG	C0751530	Subarachnoid Hemorrhage, Aneurysmal	1	CTD_human
Hgene	PPARG	C0795688	Subarachnoid Hemorrhage, Intracranial	1	CTD_human
Hgene	PPARG	C0813142	Circadian Rhythm Disorders	1	CTD_human
Hgene	PPARG	C0887800	Psychogenic Inversion of Circadian Rhythm	1	CTD_human
Hgene	PPARG	C0887850	Polycystic Kidney, Type 1 Autosomal Dominant Disease	1	CTD_human
Hgene	PPARG	C0949272	IIeocolitis	1	CTD_human
Hgene	PPARG	C1258085	Barrett Epithelium	1	CTD_human
Hgene	PPARG	C1563937	Atherogenesis	1	CTD_human
Hgene	PPARG	C1565489	Renal Insufficiency	1	CTD_human
Hgene	PPARG	C1704377	Bright Disease	1	CTD_human
Hgene	PPARG	C1720859	Familial Partial Lipodystrophy, Type 1	1	CTD_human
Hgene	PPARG	C1720860	Familial Partial Lipodystrophy, Type 2	1	CTD_human
Hgene	PPARG	C1959583	Myocardial Failure	1	CTD_human
Hgene	PPARG	C1961112	Heart Decompensation	1	CTD_human
Hgene	PPARG	C2239176	Liver carcinoma	1	CTD_human
Hgene	PPARG	C2751306	Polycystic kidney disease, type 2	1	CTD_human
Hgene	PPARG	C2931367	Thyroid cancer, follicular	1	CTD_human
Hgene	PPARG	C2936846	Scarring alopecia	1	GENOMICS_ENGLAND