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Center for Computational Systems Medicine level1
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:PPFIA1-MARK2

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: PPFIA1-MARK2
FusionPDB ID: 67404
FusionGDB2.0 ID: 67404
HgeneTgene
Gene symbol

PPFIA1

MARK2

Gene ID

8500

2011

Gene namePTPRF interacting protein alpha 1microtubule affinity regulating kinase 2
SynonymsLIP.1|LIP1|LIPRINEMK-1|EMK1|PAR-1|Par-1b|Par1b
Cytomap

11q13.3

11q13.1

Type of geneprotein-codingprotein-coding
Descriptionliprin-alpha-1LAR-interacting protein 1LIP-1Liprin-alpha1protein tyrosine phosphatase receptor type f polypeptide-interacting protein alpha-1protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1serine/threonine-protein kinase MARK2ELKL motif kinase 1MAP/microtubule affinity-regulating kinase 2PAR1 homolog bSer/Thr protein kinase PAR-1Bserine/threonine protein kinase EMKtesticular tissue protein Li 117
Modification date2020032720200329
UniProtAcc.

Q7KZI7

Ensembl transtripts involved in fusion geneENST idsENST00000253925, ENST00000389547, 
ENST00000530548, 		ENST00000315032, 
ENST00000350490, ENST00000361128, 
ENST00000377810, ENST00000502399, 
ENST00000508192, ENST00000509502, 
ENST00000513765, ENST00000408948, 
ENST00000425897, ENST00000377809, 
ENST00000402010, ENST00000413835, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score44 X 20 X 15=132007 X 6 X 3=126
# samples 6010
** MAII scorelog2(60/13200*10)=-4.4594316186373
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(10/126*10)=-0.333423733725192
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: PPFIA1 [Title/Abstract] AND MARK2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)PPFIA1(70118542)-MARK2(63662631), # samples:3
Anticipated loss of major functional domain due to fusion event.PPFIA1-MARK2 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
PPFIA1-MARK2 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
PPFIA1-MARK2 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
PPFIA1-MARK2 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneMARK2

GO:0006468

protein phosphorylation

14976552

TgeneMARK2

GO:0010976

positive regulation of neuron projection development

12429843

TgeneMARK2

GO:0018105

peptidyl-serine phosphorylation

10542369|16717194

TgeneMARK2

GO:0030010

establishment of cell polarity

12429843

TgeneMARK2

GO:0035556

intracellular signal transduction

14976552

TgeneMARK2

GO:0045197

establishment or maintenance of epithelial cell apical/basal polarity

15324659

TgeneMARK2

GO:0070507

regulation of microtubule cytoskeleton organization

10542369


check buttonFusion gene breakpoints across PPFIA1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across MARK2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-A2-A1G4-01APPFIA1chr11

70118542

-MARK2chr11

63662631

+
ChimerDB4BRCATCGA-A2-A1G4-01APPFIA1chr11

70118542

+MARK2chr11

63662631

+
ChimerDB4BRCATCGA-A2-A1G4PPFIA1chr11

70118542

+MARK2chr11

63662630

+


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000253925PPFIA1chr1170118542+ENST00000377809MARK2chr1163662631+4529479652746893
ENST00000253925PPFIA1chr1170118542+ENST00000402010MARK2chr1163662631+4574479652791908
ENST00000253925PPFIA1chr1170118542+ENST00000413835MARK2chr1163662631+4412479652629854
ENST00000389547PPFIA1chr1170118542+ENST00000377809MARK2chr1163662631+4512462482729893
ENST00000389547PPFIA1chr1170118542+ENST00000402010MARK2chr1163662631+4557462482774908
ENST00000389547PPFIA1chr1170118542+ENST00000413835MARK2chr1163662631+4395462482612854
ENST00000253925PPFIA1chr1170118542+ENST00000377809MARK2chr1163662630+4529479652746893
ENST00000253925PPFIA1chr1170118542+ENST00000402010MARK2chr1163662630+4574479652791908
ENST00000253925PPFIA1chr1170118542+ENST00000413835MARK2chr1163662630+4412479652629854
ENST00000389547PPFIA1chr1170118542+ENST00000377809MARK2chr1163662630+4512462482729893
ENST00000389547PPFIA1chr1170118542+ENST00000402010MARK2chr1163662630+4557462482774908
ENST00000389547PPFIA1chr1170118542+ENST00000413835MARK2chr1163662630+4395462482612854

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000253925ENST00000377809PPFIA1chr1170118542+MARK2chr1163662631+0.003715910.99628407
ENST00000253925ENST00000402010PPFIA1chr1170118542+MARK2chr1163662631+0.0038336690.99616635
ENST00000253925ENST00000413835PPFIA1chr1170118542+MARK2chr1163662631+0.0051007480.9948992
ENST00000389547ENST00000377809PPFIA1chr1170118542+MARK2chr1163662631+0.0037117120.9962883
ENST00000389547ENST00000402010PPFIA1chr1170118542+MARK2chr1163662631+0.0038280930.9961719
ENST00000389547ENST00000413835PPFIA1chr1170118542+MARK2chr1163662631+0.0050798010.9949202
ENST00000253925ENST00000377809PPFIA1chr1170118542+MARK2chr1163662630+0.003715910.99628407
ENST00000253925ENST00000402010PPFIA1chr1170118542+MARK2chr1163662630+0.0038336690.99616635
ENST00000253925ENST00000413835PPFIA1chr1170118542+MARK2chr1163662630+0.0051007480.9948992
ENST00000389547ENST00000377809PPFIA1chr1170118542+MARK2chr1163662630+0.0037117120.9962883
ENST00000389547ENST00000402010PPFIA1chr1170118542+MARK2chr1163662630+0.0038280930.9961719
ENST00000389547ENST00000413835PPFIA1chr1170118542+MARK2chr1163662630+0.0050798010.9949202

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>67404_67404_1_PPFIA1-MARK2_PPFIA1_chr11_70118542_ENST00000253925_MARK2_chr11_63662630_ENST00000377809_length(amino acids)=893AA_BP=136
MGRRAPGPRRGAGRRTPAAGCFRRLPSSPGASSRPRAAAEPPRPLPPASKMMCEVMPTISEAEGPPGGGGGHGSGSPSQPDADSHFEQLM
VSMLEERDRLLDTLRETQETLALTQGKLHEVGHERDSLQRQLNTALPQPTLGHLDSKPSSKSNMIRGRNSATSADEQPHIGNYRLLKTIG
KGNFAKVKLARHILTGKEVAVKIIDKTQLNSSSLQKLFREVRIMKVLNHPNIVKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEK
EARAKFRQIVSAVQYCHQKFIVHRDLKAENLLLDADMNIKIADFGFSNEFTFGNKLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLGVIL
YTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKKFLILNPSKRGTLEQIMKDRWMNVGHEDDELKPYVEPLPDYKDPRRTE
LMVSMGYTREEIQDSLVGQRYNEVMATYLLLGYKSSELEGDTITLKPRPSADLTNSSAPSPSHKVQRSVSANPKQRRFSDQAAGPAIPTS
NSYSKKTQSNNAENKRPEEDRESGRKASSTAKVPASPLPGLERKKTTPTPSTNSVLSTSTNRSRNSPLLERASLGQASIQNGKDSLTMPG
SRASTASASAAVSAARPRQHQKSMSASVHPNKASGLPPTESNCEVPRPSTAPQRVPVASPSAHNISSSGGAPDRTNFPRGVSSRSTFHAG
QLRQVRDQQNLPYGVTPASPSGHSQGRRGASGSIFSKFTSKFVRRNLSFRFARRPHVVGSGGNDKEKEEFREAKPRSLRFTWSMKTTSSM

--------------------------------------------------------------

>67404_67404_2_PPFIA1-MARK2_PPFIA1_chr11_70118542_ENST00000253925_MARK2_chr11_63662630_ENST00000402010_length(amino acids)=908AA_BP=136
MGRRAPGPRRGAGRRTPAAGCFRRLPSSPGASSRPRAAAEPPRPLPPASKMMCEVMPTISEAEGPPGGGGGHGSGSPSQPDADSHFEQLM
VSMLEERDRLLDTLRETQETLALTQGKLHEVGHERDSLQRQLNTALPQPTLGHLDSKPSSKSNMIRGRNSATSADEQPHIGNYRLLKTIG
KGNFAKVKLARHILTGKEVAVKIIDKTQLNSSSLQKLFREVRIMKVLNHPNIVKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEK
EARAKFRQIVSAVQYCHQKFIVHRDLKAENLLLDADMNIKIADFGFSNEFTFGNKLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLGVIL
YTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKKFLILNPSKRGTLEQIMKDRWMNVGHEDDELKPYVEPLPDYKDPRRTE
LMVSMGYTREEIQDSLVGQRYNEVMATYLLLGYKSSELEGDTITLKPRPSADLTNSSAPSPSHKVQRSVSANPKQRRFSDQAAGPAIPTS
NSYSKKTQSNNAENKRPEEDRESGRKASSTAKVPASPLPGLERKKTTPTPSTNSVLSTSTNRSRNSPLLERASLGQASIQNGKDSLTMPG
SRASTASASAAVSAARPRQHQKSMSASVHPNKASGLPPTESNCEVPRPSTAPQRVPVASPSAHNISSSGGAPDRTNFPRGVSSRSTFHAG
QLRQVRDQQNLPYGVTPASPSGHSQGRRGASGSIFSKFTSKFVRRNLSFRFARRNLNEPESKDRVETLRPHVVGSGGNDKEKEEFREAKP
RSLRFTWSMKTTSSMEPNEMMREIRKVLDANSCQSELHEKYMLLCMHGTPGHEDFVQWEMEVCKLPRLSLNGVRFKRISGTSMAFKNIAS

--------------------------------------------------------------

>67404_67404_3_PPFIA1-MARK2_PPFIA1_chr11_70118542_ENST00000253925_MARK2_chr11_63662630_ENST00000413835_length(amino acids)=854AA_BP=136
MGRRAPGPRRGAGRRTPAAGCFRRLPSSPGASSRPRAAAEPPRPLPPASKMMCEVMPTISEAEGPPGGGGGHGSGSPSQPDADSHFEQLM
VSMLEERDRLLDTLRETQETLALTQGKLHEVGHERDSLQRQLNTALPQPTLGHLDSKPSSKSNMIRGRNSATSADEQPHIGNYRLLKTIG
KGNFAKVKLARHILTGKEVAVKIIDKTQLNSSSLQKLFREVRIMKVLNHPNIVKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEK
EARAKFRQIVSAVQYCHQKFIVHRDLKAENLLLDADMNIKIADFGFSNEFTFGNKLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLGVIL
YTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKKFLILNPSKRGTLEQIMKDRWMNVGHEDDELKPYVEPLPDYKDPRRTE
LMVSMGYTREEIQDSLVGQRYNEVMATYLLLGYKSSELEGDTITLKPRPSADLTNSSAPSPSHKVQRSVSANPKQRRFSDQAAGPAIPTS
NSYSKKTQSNNAENKRPEEDRESGRKASSTAKVPASPLPGLERKKTTPTPSTNSVLSTSTNRSRNSPLLERASLGQASIQNGKDSTAPQR
VPVASPSAHNISSSGGAPDRTNFPRGVSSRSTFHAGQLRQVRDQQNLPYGVTPASPSGHSQGRRGASGSIFSKFTSKFVRRNLSFRFARR
NLNEPESKDRVETLRPHVVGSGGNDKEKEEFREAKPRSLRFTWSMKTTSSMEPNEMMREIRKVLDANSCQSELHEKYMLLCMHGTPGHED

--------------------------------------------------------------

>67404_67404_4_PPFIA1-MARK2_PPFIA1_chr11_70118542_ENST00000253925_MARK2_chr11_63662631_ENST00000377809_length(amino acids)=893AA_BP=136
MGRRAPGPRRGAGRRTPAAGCFRRLPSSPGASSRPRAAAEPPRPLPPASKMMCEVMPTISEAEGPPGGGGGHGSGSPSQPDADSHFEQLM
VSMLEERDRLLDTLRETQETLALTQGKLHEVGHERDSLQRQLNTALPQPTLGHLDSKPSSKSNMIRGRNSATSADEQPHIGNYRLLKTIG
KGNFAKVKLARHILTGKEVAVKIIDKTQLNSSSLQKLFREVRIMKVLNHPNIVKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEK
EARAKFRQIVSAVQYCHQKFIVHRDLKAENLLLDADMNIKIADFGFSNEFTFGNKLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLGVIL
YTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKKFLILNPSKRGTLEQIMKDRWMNVGHEDDELKPYVEPLPDYKDPRRTE
LMVSMGYTREEIQDSLVGQRYNEVMATYLLLGYKSSELEGDTITLKPRPSADLTNSSAPSPSHKVQRSVSANPKQRRFSDQAAGPAIPTS
NSYSKKTQSNNAENKRPEEDRESGRKASSTAKVPASPLPGLERKKTTPTPSTNSVLSTSTNRSRNSPLLERASLGQASIQNGKDSLTMPG
SRASTASASAAVSAARPRQHQKSMSASVHPNKASGLPPTESNCEVPRPSTAPQRVPVASPSAHNISSSGGAPDRTNFPRGVSSRSTFHAG
QLRQVRDQQNLPYGVTPASPSGHSQGRRGASGSIFSKFTSKFVRRNLSFRFARRPHVVGSGGNDKEKEEFREAKPRSLRFTWSMKTTSSM

--------------------------------------------------------------

>67404_67404_5_PPFIA1-MARK2_PPFIA1_chr11_70118542_ENST00000253925_MARK2_chr11_63662631_ENST00000402010_length(amino acids)=908AA_BP=136
MGRRAPGPRRGAGRRTPAAGCFRRLPSSPGASSRPRAAAEPPRPLPPASKMMCEVMPTISEAEGPPGGGGGHGSGSPSQPDADSHFEQLM
VSMLEERDRLLDTLRETQETLALTQGKLHEVGHERDSLQRQLNTALPQPTLGHLDSKPSSKSNMIRGRNSATSADEQPHIGNYRLLKTIG
KGNFAKVKLARHILTGKEVAVKIIDKTQLNSSSLQKLFREVRIMKVLNHPNIVKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEK
EARAKFRQIVSAVQYCHQKFIVHRDLKAENLLLDADMNIKIADFGFSNEFTFGNKLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLGVIL
YTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKKFLILNPSKRGTLEQIMKDRWMNVGHEDDELKPYVEPLPDYKDPRRTE
LMVSMGYTREEIQDSLVGQRYNEVMATYLLLGYKSSELEGDTITLKPRPSADLTNSSAPSPSHKVQRSVSANPKQRRFSDQAAGPAIPTS
NSYSKKTQSNNAENKRPEEDRESGRKASSTAKVPASPLPGLERKKTTPTPSTNSVLSTSTNRSRNSPLLERASLGQASIQNGKDSLTMPG
SRASTASASAAVSAARPRQHQKSMSASVHPNKASGLPPTESNCEVPRPSTAPQRVPVASPSAHNISSSGGAPDRTNFPRGVSSRSTFHAG
QLRQVRDQQNLPYGVTPASPSGHSQGRRGASGSIFSKFTSKFVRRNLSFRFARRNLNEPESKDRVETLRPHVVGSGGNDKEKEEFREAKP
RSLRFTWSMKTTSSMEPNEMMREIRKVLDANSCQSELHEKYMLLCMHGTPGHEDFVQWEMEVCKLPRLSLNGVRFKRISGTSMAFKNIAS

--------------------------------------------------------------

>67404_67404_6_PPFIA1-MARK2_PPFIA1_chr11_70118542_ENST00000253925_MARK2_chr11_63662631_ENST00000413835_length(amino acids)=854AA_BP=136
MGRRAPGPRRGAGRRTPAAGCFRRLPSSPGASSRPRAAAEPPRPLPPASKMMCEVMPTISEAEGPPGGGGGHGSGSPSQPDADSHFEQLM
VSMLEERDRLLDTLRETQETLALTQGKLHEVGHERDSLQRQLNTALPQPTLGHLDSKPSSKSNMIRGRNSATSADEQPHIGNYRLLKTIG
KGNFAKVKLARHILTGKEVAVKIIDKTQLNSSSLQKLFREVRIMKVLNHPNIVKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEK
EARAKFRQIVSAVQYCHQKFIVHRDLKAENLLLDADMNIKIADFGFSNEFTFGNKLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLGVIL
YTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKKFLILNPSKRGTLEQIMKDRWMNVGHEDDELKPYVEPLPDYKDPRRTE
LMVSMGYTREEIQDSLVGQRYNEVMATYLLLGYKSSELEGDTITLKPRPSADLTNSSAPSPSHKVQRSVSANPKQRRFSDQAAGPAIPTS
NSYSKKTQSNNAENKRPEEDRESGRKASSTAKVPASPLPGLERKKTTPTPSTNSVLSTSTNRSRNSPLLERASLGQASIQNGKDSTAPQR
VPVASPSAHNISSSGGAPDRTNFPRGVSSRSTFHAGQLRQVRDQQNLPYGVTPASPSGHSQGRRGASGSIFSKFTSKFVRRNLSFRFARR
NLNEPESKDRVETLRPHVVGSGGNDKEKEEFREAKPRSLRFTWSMKTTSSMEPNEMMREIRKVLDANSCQSELHEKYMLLCMHGTPGHED

--------------------------------------------------------------

>67404_67404_7_PPFIA1-MARK2_PPFIA1_chr11_70118542_ENST00000389547_MARK2_chr11_63662630_ENST00000377809_length(amino acids)=893AA_BP=136
MGRRAPGPRRGAGRRTPAAGCFRRLPSSPGASSRPRAAAEPPRPLPPASKMMCEVMPTISEAEGPPGGGGGHGSGSPSQPDADSHFEQLM
VSMLEERDRLLDTLRETQETLALTQGKLHEVGHERDSLQRQLNTALPQPTLGHLDSKPSSKSNMIRGRNSATSADEQPHIGNYRLLKTIG
KGNFAKVKLARHILTGKEVAVKIIDKTQLNSSSLQKLFREVRIMKVLNHPNIVKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEK
EARAKFRQIVSAVQYCHQKFIVHRDLKAENLLLDADMNIKIADFGFSNEFTFGNKLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLGVIL
YTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKKFLILNPSKRGTLEQIMKDRWMNVGHEDDELKPYVEPLPDYKDPRRTE
LMVSMGYTREEIQDSLVGQRYNEVMATYLLLGYKSSELEGDTITLKPRPSADLTNSSAPSPSHKVQRSVSANPKQRRFSDQAAGPAIPTS
NSYSKKTQSNNAENKRPEEDRESGRKASSTAKVPASPLPGLERKKTTPTPSTNSVLSTSTNRSRNSPLLERASLGQASIQNGKDSLTMPG
SRASTASASAAVSAARPRQHQKSMSASVHPNKASGLPPTESNCEVPRPSTAPQRVPVASPSAHNISSSGGAPDRTNFPRGVSSRSTFHAG
QLRQVRDQQNLPYGVTPASPSGHSQGRRGASGSIFSKFTSKFVRRNLSFRFARRPHVVGSGGNDKEKEEFREAKPRSLRFTWSMKTTSSM

--------------------------------------------------------------

>67404_67404_8_PPFIA1-MARK2_PPFIA1_chr11_70118542_ENST00000389547_MARK2_chr11_63662630_ENST00000402010_length(amino acids)=908AA_BP=136
MGRRAPGPRRGAGRRTPAAGCFRRLPSSPGASSRPRAAAEPPRPLPPASKMMCEVMPTISEAEGPPGGGGGHGSGSPSQPDADSHFEQLM
VSMLEERDRLLDTLRETQETLALTQGKLHEVGHERDSLQRQLNTALPQPTLGHLDSKPSSKSNMIRGRNSATSADEQPHIGNYRLLKTIG
KGNFAKVKLARHILTGKEVAVKIIDKTQLNSSSLQKLFREVRIMKVLNHPNIVKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEK
EARAKFRQIVSAVQYCHQKFIVHRDLKAENLLLDADMNIKIADFGFSNEFTFGNKLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLGVIL
YTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKKFLILNPSKRGTLEQIMKDRWMNVGHEDDELKPYVEPLPDYKDPRRTE
LMVSMGYTREEIQDSLVGQRYNEVMATYLLLGYKSSELEGDTITLKPRPSADLTNSSAPSPSHKVQRSVSANPKQRRFSDQAAGPAIPTS
NSYSKKTQSNNAENKRPEEDRESGRKASSTAKVPASPLPGLERKKTTPTPSTNSVLSTSTNRSRNSPLLERASLGQASIQNGKDSLTMPG
SRASTASASAAVSAARPRQHQKSMSASVHPNKASGLPPTESNCEVPRPSTAPQRVPVASPSAHNISSSGGAPDRTNFPRGVSSRSTFHAG
QLRQVRDQQNLPYGVTPASPSGHSQGRRGASGSIFSKFTSKFVRRNLSFRFARRNLNEPESKDRVETLRPHVVGSGGNDKEKEEFREAKP
RSLRFTWSMKTTSSMEPNEMMREIRKVLDANSCQSELHEKYMLLCMHGTPGHEDFVQWEMEVCKLPRLSLNGVRFKRISGTSMAFKNIAS

--------------------------------------------------------------

>67404_67404_9_PPFIA1-MARK2_PPFIA1_chr11_70118542_ENST00000389547_MARK2_chr11_63662630_ENST00000413835_length(amino acids)=854AA_BP=136
MGRRAPGPRRGAGRRTPAAGCFRRLPSSPGASSRPRAAAEPPRPLPPASKMMCEVMPTISEAEGPPGGGGGHGSGSPSQPDADSHFEQLM
VSMLEERDRLLDTLRETQETLALTQGKLHEVGHERDSLQRQLNTALPQPTLGHLDSKPSSKSNMIRGRNSATSADEQPHIGNYRLLKTIG
KGNFAKVKLARHILTGKEVAVKIIDKTQLNSSSLQKLFREVRIMKVLNHPNIVKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEK
EARAKFRQIVSAVQYCHQKFIVHRDLKAENLLLDADMNIKIADFGFSNEFTFGNKLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLGVIL
YTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKKFLILNPSKRGTLEQIMKDRWMNVGHEDDELKPYVEPLPDYKDPRRTE
LMVSMGYTREEIQDSLVGQRYNEVMATYLLLGYKSSELEGDTITLKPRPSADLTNSSAPSPSHKVQRSVSANPKQRRFSDQAAGPAIPTS
NSYSKKTQSNNAENKRPEEDRESGRKASSTAKVPASPLPGLERKKTTPTPSTNSVLSTSTNRSRNSPLLERASLGQASIQNGKDSTAPQR
VPVASPSAHNISSSGGAPDRTNFPRGVSSRSTFHAGQLRQVRDQQNLPYGVTPASPSGHSQGRRGASGSIFSKFTSKFVRRNLSFRFARR
NLNEPESKDRVETLRPHVVGSGGNDKEKEEFREAKPRSLRFTWSMKTTSSMEPNEMMREIRKVLDANSCQSELHEKYMLLCMHGTPGHED

--------------------------------------------------------------

>67404_67404_10_PPFIA1-MARK2_PPFIA1_chr11_70118542_ENST00000389547_MARK2_chr11_63662631_ENST00000377809_length(amino acids)=893AA_BP=136
MGRRAPGPRRGAGRRTPAAGCFRRLPSSPGASSRPRAAAEPPRPLPPASKMMCEVMPTISEAEGPPGGGGGHGSGSPSQPDADSHFEQLM
VSMLEERDRLLDTLRETQETLALTQGKLHEVGHERDSLQRQLNTALPQPTLGHLDSKPSSKSNMIRGRNSATSADEQPHIGNYRLLKTIG
KGNFAKVKLARHILTGKEVAVKIIDKTQLNSSSLQKLFREVRIMKVLNHPNIVKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEK
EARAKFRQIVSAVQYCHQKFIVHRDLKAENLLLDADMNIKIADFGFSNEFTFGNKLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLGVIL
YTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKKFLILNPSKRGTLEQIMKDRWMNVGHEDDELKPYVEPLPDYKDPRRTE
LMVSMGYTREEIQDSLVGQRYNEVMATYLLLGYKSSELEGDTITLKPRPSADLTNSSAPSPSHKVQRSVSANPKQRRFSDQAAGPAIPTS
NSYSKKTQSNNAENKRPEEDRESGRKASSTAKVPASPLPGLERKKTTPTPSTNSVLSTSTNRSRNSPLLERASLGQASIQNGKDSLTMPG
SRASTASASAAVSAARPRQHQKSMSASVHPNKASGLPPTESNCEVPRPSTAPQRVPVASPSAHNISSSGGAPDRTNFPRGVSSRSTFHAG
QLRQVRDQQNLPYGVTPASPSGHSQGRRGASGSIFSKFTSKFVRRNLSFRFARRPHVVGSGGNDKEKEEFREAKPRSLRFTWSMKTTSSM

--------------------------------------------------------------

>67404_67404_11_PPFIA1-MARK2_PPFIA1_chr11_70118542_ENST00000389547_MARK2_chr11_63662631_ENST00000402010_length(amino acids)=908AA_BP=136
MGRRAPGPRRGAGRRTPAAGCFRRLPSSPGASSRPRAAAEPPRPLPPASKMMCEVMPTISEAEGPPGGGGGHGSGSPSQPDADSHFEQLM
VSMLEERDRLLDTLRETQETLALTQGKLHEVGHERDSLQRQLNTALPQPTLGHLDSKPSSKSNMIRGRNSATSADEQPHIGNYRLLKTIG
KGNFAKVKLARHILTGKEVAVKIIDKTQLNSSSLQKLFREVRIMKVLNHPNIVKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEK
EARAKFRQIVSAVQYCHQKFIVHRDLKAENLLLDADMNIKIADFGFSNEFTFGNKLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLGVIL
YTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKKFLILNPSKRGTLEQIMKDRWMNVGHEDDELKPYVEPLPDYKDPRRTE
LMVSMGYTREEIQDSLVGQRYNEVMATYLLLGYKSSELEGDTITLKPRPSADLTNSSAPSPSHKVQRSVSANPKQRRFSDQAAGPAIPTS
NSYSKKTQSNNAENKRPEEDRESGRKASSTAKVPASPLPGLERKKTTPTPSTNSVLSTSTNRSRNSPLLERASLGQASIQNGKDSLTMPG
SRASTASASAAVSAARPRQHQKSMSASVHPNKASGLPPTESNCEVPRPSTAPQRVPVASPSAHNISSSGGAPDRTNFPRGVSSRSTFHAG
QLRQVRDQQNLPYGVTPASPSGHSQGRRGASGSIFSKFTSKFVRRNLSFRFARRNLNEPESKDRVETLRPHVVGSGGNDKEKEEFREAKP
RSLRFTWSMKTTSSMEPNEMMREIRKVLDANSCQSELHEKYMLLCMHGTPGHEDFVQWEMEVCKLPRLSLNGVRFKRISGTSMAFKNIAS

--------------------------------------------------------------

>67404_67404_12_PPFIA1-MARK2_PPFIA1_chr11_70118542_ENST00000389547_MARK2_chr11_63662631_ENST00000413835_length(amino acids)=854AA_BP=136
MGRRAPGPRRGAGRRTPAAGCFRRLPSSPGASSRPRAAAEPPRPLPPASKMMCEVMPTISEAEGPPGGGGGHGSGSPSQPDADSHFEQLM
VSMLEERDRLLDTLRETQETLALTQGKLHEVGHERDSLQRQLNTALPQPTLGHLDSKPSSKSNMIRGRNSATSADEQPHIGNYRLLKTIG
KGNFAKVKLARHILTGKEVAVKIIDKTQLNSSSLQKLFREVRIMKVLNHPNIVKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEK
EARAKFRQIVSAVQYCHQKFIVHRDLKAENLLLDADMNIKIADFGFSNEFTFGNKLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLGVIL
YTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKKFLILNPSKRGTLEQIMKDRWMNVGHEDDELKPYVEPLPDYKDPRRTE
LMVSMGYTREEIQDSLVGQRYNEVMATYLLLGYKSSELEGDTITLKPRPSADLTNSSAPSPSHKVQRSVSANPKQRRFSDQAAGPAIPTS
NSYSKKTQSNNAENKRPEEDRESGRKASSTAKVPASPLPGLERKKTTPTPSTNSVLSTSTNRSRNSPLLERASLGQASIQNGKDSTAPQR
VPVASPSAHNISSSGGAPDRTNFPRGVSSRSTFHAGQLRQVRDQQNLPYGVTPASPSGHSQGRRGASGSIFSKFTSKFVRRNLSFRFARR
NLNEPESKDRVETLRPHVVGSGGNDKEKEEFREAKPRSLRFTWSMKTTSSMEPNEMMREIRKVLDANSCQSELHEKYMLLCMHGTPGHED

--------------------------------------------------------------

Top

Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr11:70118542/chr11:63662631)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.MARK2

Q7KZI7

FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Serine/threonine-protein kinase (PubMed:23666762). Involved in cell polarity and microtubule dynamics regulation. Phosphorylates CRTC2/TORC2, DCX, HDAC7, KIF13B, MAP2, MAP4 and RAB11FIP2. Phosphorylates the microtubule-associated protein MAPT/TAU (PubMed:23666762). Plays a key role in cell polarity by phosphorylating the microtubule-associated proteins MAP2, MAP4 and MAPT/TAU at KXGS motifs, causing detachment from microtubules, and their disassembly. Regulates epithelial cell polarity by phosphorylating RAB11FIP2. Involved in the regulation of neuronal migration through its dual activities in regulating cellular polarity and microtubule dynamics, possibly by phosphorylating and regulating DCX. Regulates axogenesis by phosphorylating KIF13B, promoting interaction between KIF13B and 14-3-3 and inhibiting microtubule-dependent accumulation of KIF13B. Also required for neurite outgrowth and establishment of neuronal polarity. Regulates localization and activity of some histone deacetylases by mediating phosphorylation of HDAC7, promoting subsequent interaction between HDAC7 and 14-3-3 and export from the nucleus. Also acts as a positive regulator of the Wnt signaling pathway, probably by mediating phosphorylation of dishevelled proteins (DVL1, DVL2 and/or DVL3). Modulates the developmental decision to build a columnar versus a hepatic epithelial cell apparently by promoting a switch from a direct to a transcytotic mode of apical protein delivery. Essential for the asymmetric development of membrane domains of polarized epithelial cells. {ECO:0000269|PubMed:11433294, ECO:0000269|PubMed:12429843, ECO:0000269|PubMed:14976552, ECO:0000269|PubMed:15158914, ECO:0000269|PubMed:15324659, ECO:0000269|PubMed:15365179, ECO:0000269|PubMed:16775013, ECO:0000269|PubMed:16980613, ECO:0000269|PubMed:18626018, ECO:0000269|PubMed:20194617, ECO:0000269|PubMed:23666762}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePPFIA1chr11:70118542chr11:63662630ENST00000253925+22817_2588.01597.3333333333333Compositional biasNote=Poly-Gly
HgenePPFIA1chr11:70118542chr11:63662630ENST00000389547+22617_2588.01186.0Compositional biasNote=Poly-Gly
HgenePPFIA1chr11:70118542chr11:63662631ENST00000253925+22817_2588.01597.3333333333333Compositional biasNote=Poly-Gly
HgenePPFIA1chr11:70118542chr11:63662631ENST00000389547+22617_2588.01186.0Compositional biasNote=Poly-Gly
TgeneMARK2chr11:70118542chr11:63662630ENST00000315032018323_36218.0780.0DomainUBA
TgeneMARK2chr11:70118542chr11:63662630ENST0000031503201853_30418.0780.0DomainProtein kinase
TgeneMARK2chr11:70118542chr11:63662630ENST00000315032018739_78818.0780.0DomainKA1
TgeneMARK2chr11:70118542chr11:63662630ENST00000350490016323_36218.0710.0DomainUBA
TgeneMARK2chr11:70118542chr11:63662630ENST0000035049001653_30418.0710.0DomainProtein kinase
TgeneMARK2chr11:70118542chr11:63662630ENST00000350490016739_78818.0710.0DomainKA1
TgeneMARK2chr11:70118542chr11:63662630ENST00000361128017323_36218.0720.0DomainUBA
TgeneMARK2chr11:70118542chr11:63662630ENST0000036112801753_30418.0720.0DomainProtein kinase
TgeneMARK2chr11:70118542chr11:63662630ENST00000361128017739_78818.0720.0DomainKA1
TgeneMARK2chr11:70118542chr11:63662630ENST00000377809018323_36218.0774.0DomainUBA
TgeneMARK2chr11:70118542chr11:63662630ENST0000037780901853_30418.0774.0DomainProtein kinase
TgeneMARK2chr11:70118542chr11:63662630ENST00000377809018739_78818.0774.0DomainKA1
TgeneMARK2chr11:70118542chr11:63662630ENST00000377810017323_3620692.0DomainUBA
TgeneMARK2chr11:70118542chr11:63662630ENST0000037781001753_3040692.0DomainProtein kinase
TgeneMARK2chr11:70118542chr11:63662630ENST00000377810017739_7880692.0DomainKA1
TgeneMARK2chr11:70118542chr11:63662630ENST00000402010019323_36218.0789.0DomainUBA
TgeneMARK2chr11:70118542chr11:63662630ENST0000040201001953_30418.0789.0DomainProtein kinase
TgeneMARK2chr11:70118542chr11:63662630ENST00000402010019739_78818.0789.0DomainKA1
TgeneMARK2chr11:70118542chr11:63662630ENST00000408948016323_3620692.0DomainUBA
TgeneMARK2chr11:70118542chr11:63662630ENST0000040894801653_3040692.0DomainProtein kinase
TgeneMARK2chr11:70118542chr11:63662630ENST00000408948016739_7880692.0DomainKA1
TgeneMARK2chr11:70118542chr11:63662630ENST00000413835018323_36218.0735.0DomainUBA
TgeneMARK2chr11:70118542chr11:63662630ENST0000041383501853_30418.0735.0DomainProtein kinase
TgeneMARK2chr11:70118542chr11:63662630ENST00000413835018739_78818.0735.0DomainKA1
TgeneMARK2chr11:70118542chr11:63662630ENST00000508192017323_36218.0725.0DomainUBA
TgeneMARK2chr11:70118542chr11:63662630ENST0000050819201753_30418.0725.0DomainProtein kinase
TgeneMARK2chr11:70118542chr11:63662630ENST00000508192017739_78818.0725.0DomainKA1
TgeneMARK2chr11:70118542chr11:63662630ENST00000509502018323_3620746.0DomainUBA
TgeneMARK2chr11:70118542chr11:63662630ENST0000050950201853_3040746.0DomainProtein kinase
TgeneMARK2chr11:70118542chr11:63662630ENST00000509502018739_7880746.0DomainKA1
TgeneMARK2chr11:70118542chr11:63662630ENST00000513765-118323_36245.0756.0DomainUBA
TgeneMARK2chr11:70118542chr11:63662630ENST00000513765-11853_30445.0756.0DomainProtein kinase
TgeneMARK2chr11:70118542chr11:63662630ENST00000513765-118739_78845.0756.0DomainKA1
TgeneMARK2chr11:70118542chr11:63662631ENST00000315032018323_36218.0780.0DomainUBA
TgeneMARK2chr11:70118542chr11:63662631ENST0000031503201853_30418.0780.0DomainProtein kinase
TgeneMARK2chr11:70118542chr11:63662631ENST00000315032018739_78818.0780.0DomainKA1
TgeneMARK2chr11:70118542chr11:63662631ENST00000350490016323_36218.0710.0DomainUBA
TgeneMARK2chr11:70118542chr11:63662631ENST0000035049001653_30418.0710.0DomainProtein kinase
TgeneMARK2chr11:70118542chr11:63662631ENST00000350490016739_78818.0710.0DomainKA1
TgeneMARK2chr11:70118542chr11:63662631ENST00000361128017323_36218.0720.0DomainUBA
TgeneMARK2chr11:70118542chr11:63662631ENST0000036112801753_30418.0720.0DomainProtein kinase
TgeneMARK2chr11:70118542chr11:63662631ENST00000361128017739_78818.0720.0DomainKA1
TgeneMARK2chr11:70118542chr11:63662631ENST00000377809018323_36218.0774.0DomainUBA
TgeneMARK2chr11:70118542chr11:63662631ENST0000037780901853_30418.0774.0DomainProtein kinase
TgeneMARK2chr11:70118542chr11:63662631ENST00000377809018739_78818.0774.0DomainKA1
TgeneMARK2chr11:70118542chr11:63662631ENST00000377810017323_3620692.0DomainUBA
TgeneMARK2chr11:70118542chr11:63662631ENST0000037781001753_3040692.0DomainProtein kinase
TgeneMARK2chr11:70118542chr11:63662631ENST00000377810017739_7880692.0DomainKA1
TgeneMARK2chr11:70118542chr11:63662631ENST00000402010019323_36218.0789.0DomainUBA
TgeneMARK2chr11:70118542chr11:63662631ENST0000040201001953_30418.0789.0DomainProtein kinase
TgeneMARK2chr11:70118542chr11:63662631ENST00000402010019739_78818.0789.0DomainKA1
TgeneMARK2chr11:70118542chr11:63662631ENST00000408948016323_3620692.0DomainUBA
TgeneMARK2chr11:70118542chr11:63662631ENST0000040894801653_3040692.0DomainProtein kinase
TgeneMARK2chr11:70118542chr11:63662631ENST00000408948016739_7880692.0DomainKA1
TgeneMARK2chr11:70118542chr11:63662631ENST00000413835018323_36218.0735.0DomainUBA
TgeneMARK2chr11:70118542chr11:63662631ENST0000041383501853_30418.0735.0DomainProtein kinase
TgeneMARK2chr11:70118542chr11:63662631ENST00000413835018739_78818.0735.0DomainKA1
TgeneMARK2chr11:70118542chr11:63662631ENST00000508192017323_36218.0725.0DomainUBA
TgeneMARK2chr11:70118542chr11:63662631ENST0000050819201753_30418.0725.0DomainProtein kinase
TgeneMARK2chr11:70118542chr11:63662631ENST00000508192017739_78818.0725.0DomainKA1
TgeneMARK2chr11:70118542chr11:63662631ENST00000509502018323_3620746.0DomainUBA
TgeneMARK2chr11:70118542chr11:63662631ENST0000050950201853_3040746.0DomainProtein kinase
TgeneMARK2chr11:70118542chr11:63662631ENST00000509502018739_7880746.0DomainKA1
TgeneMARK2chr11:70118542chr11:63662631ENST00000513765-118323_36245.0756.0DomainUBA
TgeneMARK2chr11:70118542chr11:63662631ENST00000513765-11853_30445.0756.0DomainProtein kinase
TgeneMARK2chr11:70118542chr11:63662631ENST00000513765-118739_78845.0756.0DomainKA1
TgeneMARK2chr11:70118542chr11:63662630ENST0000031503201859_6718.0780.0Nucleotide bindingATP
TgeneMARK2chr11:70118542chr11:63662630ENST0000035049001659_6718.0710.0Nucleotide bindingATP
TgeneMARK2chr11:70118542chr11:63662630ENST0000036112801759_6718.0720.0Nucleotide bindingATP
TgeneMARK2chr11:70118542chr11:63662630ENST0000037780901859_6718.0774.0Nucleotide bindingATP
TgeneMARK2chr11:70118542chr11:63662630ENST0000037781001759_670692.0Nucleotide bindingATP
TgeneMARK2chr11:70118542chr11:63662630ENST0000040201001959_6718.0789.0Nucleotide bindingATP
TgeneMARK2chr11:70118542chr11:63662630ENST0000040894801659_670692.0Nucleotide bindingATP
TgeneMARK2chr11:70118542chr11:63662630ENST0000041383501859_6718.0735.0Nucleotide bindingATP
TgeneMARK2chr11:70118542chr11:63662630ENST0000050819201759_6718.0725.0Nucleotide bindingATP
TgeneMARK2chr11:70118542chr11:63662630ENST0000050950201859_670746.0Nucleotide bindingATP
TgeneMARK2chr11:70118542chr11:63662630ENST00000513765-11859_6745.0756.0Nucleotide bindingATP
TgeneMARK2chr11:70118542chr11:63662631ENST0000031503201859_6718.0780.0Nucleotide bindingATP
TgeneMARK2chr11:70118542chr11:63662631ENST0000035049001659_6718.0710.0Nucleotide bindingATP
TgeneMARK2chr11:70118542chr11:63662631ENST0000036112801759_6718.0720.0Nucleotide bindingATP
TgeneMARK2chr11:70118542chr11:63662631ENST0000037780901859_6718.0774.0Nucleotide bindingATP
TgeneMARK2chr11:70118542chr11:63662631ENST0000037781001759_670692.0Nucleotide bindingATP
TgeneMARK2chr11:70118542chr11:63662631ENST0000040201001959_6718.0789.0Nucleotide bindingATP
TgeneMARK2chr11:70118542chr11:63662631ENST0000040894801659_670692.0Nucleotide bindingATP
TgeneMARK2chr11:70118542chr11:63662631ENST0000041383501859_6718.0735.0Nucleotide bindingATP
TgeneMARK2chr11:70118542chr11:63662631ENST0000050819201759_6718.0725.0Nucleotide bindingATP
TgeneMARK2chr11:70118542chr11:63662631ENST0000050950201859_670746.0Nucleotide bindingATP
TgeneMARK2chr11:70118542chr11:63662631ENST00000513765-11859_6745.0756.0Nucleotide bindingATP

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePPFIA1chr11:70118542chr11:63662630ENST00000253925+2281021_105088.01597.3333333333333Coiled coilOntology_term=ECO:0000255
HgenePPFIA1chr11:70118542chr11:63662630ENST00000253925+228176_21488.01597.3333333333333Coiled coilOntology_term=ECO:0000255
HgenePPFIA1chr11:70118542chr11:63662630ENST00000253925+228249_52188.01597.3333333333333Coiled coilOntology_term=ECO:0000255
HgenePPFIA1chr11:70118542chr11:63662630ENST00000253925+22834_14188.01597.3333333333333Coiled coilOntology_term=ECO:0000255
HgenePPFIA1chr11:70118542chr11:63662630ENST00000253925+228623_66988.01597.3333333333333Coiled coilOntology_term=ECO:0000255
HgenePPFIA1chr11:70118542chr11:63662630ENST00000253925+228847_87188.01597.3333333333333Coiled coilOntology_term=ECO:0000255
HgenePPFIA1chr11:70118542chr11:63662630ENST00000389547+2261021_105088.01186.0Coiled coilOntology_term=ECO:0000255
HgenePPFIA1chr11:70118542chr11:63662630ENST00000389547+226176_21488.01186.0Coiled coilOntology_term=ECO:0000255
HgenePPFIA1chr11:70118542chr11:63662630ENST00000389547+226249_52188.01186.0Coiled coilOntology_term=ECO:0000255
HgenePPFIA1chr11:70118542chr11:63662630ENST00000389547+22634_14188.01186.0Coiled coilOntology_term=ECO:0000255
HgenePPFIA1chr11:70118542chr11:63662630ENST00000389547+226623_66988.01186.0Coiled coilOntology_term=ECO:0000255
HgenePPFIA1chr11:70118542chr11:63662630ENST00000389547+226847_87188.01186.0Coiled coilOntology_term=ECO:0000255
HgenePPFIA1chr11:70118542chr11:63662631ENST00000253925+2281021_105088.01597.3333333333333Coiled coilOntology_term=ECO:0000255
HgenePPFIA1chr11:70118542chr11:63662631ENST00000253925+228176_21488.01597.3333333333333Coiled coilOntology_term=ECO:0000255
HgenePPFIA1chr11:70118542chr11:63662631ENST00000253925+228249_52188.01597.3333333333333Coiled coilOntology_term=ECO:0000255
HgenePPFIA1chr11:70118542chr11:63662631ENST00000253925+22834_14188.01597.3333333333333Coiled coilOntology_term=ECO:0000255
HgenePPFIA1chr11:70118542chr11:63662631ENST00000253925+228623_66988.01597.3333333333333Coiled coilOntology_term=ECO:0000255
HgenePPFIA1chr11:70118542chr11:63662631ENST00000253925+228847_87188.01597.3333333333333Coiled coilOntology_term=ECO:0000255
HgenePPFIA1chr11:70118542chr11:63662631ENST00000389547+2261021_105088.01186.0Coiled coilOntology_term=ECO:0000255
HgenePPFIA1chr11:70118542chr11:63662631ENST00000389547+226176_21488.01186.0Coiled coilOntology_term=ECO:0000255
HgenePPFIA1chr11:70118542chr11:63662631ENST00000389547+226249_52188.01186.0Coiled coilOntology_term=ECO:0000255
HgenePPFIA1chr11:70118542chr11:63662631ENST00000389547+22634_14188.01186.0Coiled coilOntology_term=ECO:0000255
HgenePPFIA1chr11:70118542chr11:63662631ENST00000389547+226623_66988.01186.0Coiled coilOntology_term=ECO:0000255
HgenePPFIA1chr11:70118542chr11:63662631ENST00000389547+226847_87188.01186.0Coiled coilOntology_term=ECO:0000255
HgenePPFIA1chr11:70118542chr11:63662630ENST00000253925+2281051_112088.01597.3333333333333DomainSAM 3
HgenePPFIA1chr11:70118542chr11:63662630ENST00000253925+228878_94488.01597.3333333333333DomainSAM 1
HgenePPFIA1chr11:70118542chr11:63662630ENST00000253925+228963_102788.01597.3333333333333DomainSAM 2
HgenePPFIA1chr11:70118542chr11:63662630ENST00000389547+2261051_112088.01186.0DomainSAM 3
HgenePPFIA1chr11:70118542chr11:63662630ENST00000389547+226878_94488.01186.0DomainSAM 1
HgenePPFIA1chr11:70118542chr11:63662630ENST00000389547+226963_102788.01186.0DomainSAM 2
HgenePPFIA1chr11:70118542chr11:63662631ENST00000253925+2281051_112088.01597.3333333333333DomainSAM 3
HgenePPFIA1chr11:70118542chr11:63662631ENST00000253925+228878_94488.01597.3333333333333DomainSAM 1
HgenePPFIA1chr11:70118542chr11:63662631ENST00000253925+228963_102788.01597.3333333333333DomainSAM 2
HgenePPFIA1chr11:70118542chr11:63662631ENST00000389547+2261051_112088.01186.0DomainSAM 3
HgenePPFIA1chr11:70118542chr11:63662631ENST00000389547+226878_94488.01186.0DomainSAM 1
HgenePPFIA1chr11:70118542chr11:63662631ENST00000389547+226963_102788.01186.0DomainSAM 2


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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
PPFIA1
MARK2


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to PPFIA1-MARK2


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to PPFIA1-MARK2


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource