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Center for Computational Systems Medicine level2
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein Structure

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pLDDT scores

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Ramachandran Plot of Fusion Protein Structure

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:PPFIA1-RBFOX2

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: PPFIA1-RBFOX2
FusionPDB ID: 67412
FusionGDB2.0 ID: 67412
HgeneTgene
Gene symbol

PPFIA1

RBFOX2

Gene ID

8500

23543

Gene namePTPRF interacting protein alpha 1RNA binding fox-1 homolog 2
SynonymsLIP.1|LIP1|LIPRINFOX2|Fox-2|HNRBP2|HRNBP2|RBM9|RTA|dJ106I20.3|fxh
Cytomap

11q13.3

22q12.3

Type of geneprotein-codingprotein-coding
Descriptionliprin-alpha-1LAR-interacting protein 1LIP-1Liprin-alpha1protein tyrosine phosphatase receptor type f polypeptide-interacting protein alpha-1protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1RNA binding protein fox-1 homolog 2RNA binding protein, fox-1 homolog 2RNA-binding motif protein 9fox-1 homolog Bfox-1 homologuehexaribonucleotide-binding protein 2repressor of tamoxifen transcriptional activity
Modification date2020032720200327
UniProtAcc..
Ensembl transtripts involved in fusion geneENST idsENST00000253925, ENST00000389547, 
ENST00000530548, 		ENST00000262829, 
ENST00000359369, ENST00000397303, 
ENST00000405409, ENST00000414461, 
ENST00000416721, ENST00000438146, 
ENST00000449924, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score44 X 20 X 15=1320034 X 34 X 8=9248
# samples 6039
** MAII scorelog2(60/13200*10)=-4.4594316186373
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(39/9248*10)=-4.56759536875107
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: PPFIA1 [Title/Abstract] AND RBFOX2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)PPFIA1(70118542)-RBFOX2(36164396), # samples:4
Anticipated loss of major functional domain due to fusion event.PPFIA1-RBFOX2 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
PPFIA1-RBFOX2 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
PPFIA1-RBFOX2 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
PPFIA1-RBFOX2 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneRBFOX2

GO:0030520

intracellular estrogen receptor signaling pathway

11875103

TgeneRBFOX2

GO:0045892

negative regulation of transcription, DNA-templated

11875103


check buttonFusion gene breakpoints across PPFIA1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across RBFOX2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LUSCTCGA-85-A4QQ-01APPFIA1chr11

70118541

+RBFOX2chr22

36164395

-
ChimerDB4LUSCTCGA-85-A4QQ-01APPFIA1chr11

70118542

-RBFOX2chr22

36164396

-
ChimerDB4LUSCTCGA-85-A4QQ-01APPFIA1chr11

70118542

+RBFOX2chr22

36164396

-
ChimerDB4LUSCTCGA-85-A4QQPPFIA1chr11

70118542

+RBFOX2chr22

36161530

-
ChimerDB4LUSCTCGA-85-A4QQPPFIA1chr11

70118542

+RBFOX2chr22

36164396

-


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000253925PPFIA1chr1170118542+ENST00000405409RBFOX2chr2236164396-6589479651129354
ENST00000253925PPFIA1chr1170118542+ENST00000414461RBFOX2chr2236164396-1735479651141358
ENST00000253925PPFIA1chr1170118542+ENST00000449924RBFOX2chr2236164396-1775479651171368
ENST00000253925PPFIA1chr1170118542+ENST00000262829RBFOX2chr2236164396-1432479651159364
ENST00000253925PPFIA1chr1170118542+ENST00000397303RBFOX2chr2236164396-1407479651159364
ENST00000253925PPFIA1chr1170118542+ENST00000359369RBFOX2chr2236164396-1414479651201378
ENST00000253925PPFIA1chr1170118542+ENST00000416721RBFOX2chr2236164396-1217479651159364
ENST00000253925PPFIA1chr1170118542+ENST00000438146RBFOX2chr2236164396-1172479651171369
ENST00000389547PPFIA1chr1170118542+ENST00000405409RBFOX2chr2236164396-6572462481112354
ENST00000389547PPFIA1chr1170118542+ENST00000414461RBFOX2chr2236164396-1718462481124358
ENST00000389547PPFIA1chr1170118542+ENST00000449924RBFOX2chr2236164396-1758462481154368
ENST00000389547PPFIA1chr1170118542+ENST00000262829RBFOX2chr2236164396-1415462481142364
ENST00000389547PPFIA1chr1170118542+ENST00000397303RBFOX2chr2236164396-1390462481142364
ENST00000389547PPFIA1chr1170118542+ENST00000359369RBFOX2chr2236164396-1397462481184378
ENST00000389547PPFIA1chr1170118542+ENST00000416721RBFOX2chr2236164396-1200462481142364
ENST00000389547PPFIA1chr1170118542+ENST00000438146RBFOX2chr2236164396-1155462481154368
ENST00000253925PPFIA1chr1170118542+ENST00000405409RBFOX2chr2236161530-6496479651036323
ENST00000253925PPFIA1chr1170118542+ENST00000414461RBFOX2chr2236161530-1642479651048327
ENST00000253925PPFIA1chr1170118542+ENST00000449924RBFOX2chr2236161530-1682479651078337
ENST00000253925PPFIA1chr1170118542+ENST00000262829RBFOX2chr2236161530-1339479651066333
ENST00000253925PPFIA1chr1170118542+ENST00000397303RBFOX2chr2236161530-1314479651066333
ENST00000253925PPFIA1chr1170118542+ENST00000359369RBFOX2chr2236161530-1321479651108347
ENST00000253925PPFIA1chr1170118542+ENST00000416721RBFOX2chr2236161530-1124479651066333
ENST00000253925PPFIA1chr1170118542+ENST00000438146RBFOX2chr2236161530-1079479651078338
ENST00000389547PPFIA1chr1170118542+ENST00000405409RBFOX2chr2236161530-6479462481019323
ENST00000389547PPFIA1chr1170118542+ENST00000414461RBFOX2chr2236161530-1625462481031327
ENST00000389547PPFIA1chr1170118542+ENST00000449924RBFOX2chr2236161530-1665462481061337
ENST00000389547PPFIA1chr1170118542+ENST00000262829RBFOX2chr2236161530-1322462481049333
ENST00000389547PPFIA1chr1170118542+ENST00000397303RBFOX2chr2236161530-1297462481049333
ENST00000389547PPFIA1chr1170118542+ENST00000359369RBFOX2chr2236161530-1304462481091347
ENST00000389547PPFIA1chr1170118542+ENST00000416721RBFOX2chr2236161530-1107462481049333
ENST00000389547PPFIA1chr1170118542+ENST00000438146RBFOX2chr2236161530-1062462481061337
ENST00000253925PPFIA1chr1170118541+ENST00000405409RBFOX2chr2236164395-6589479651129354
ENST00000253925PPFIA1chr1170118541+ENST00000414461RBFOX2chr2236164395-1735479651141358
ENST00000253925PPFIA1chr1170118541+ENST00000449924RBFOX2chr2236164395-1775479651171368
ENST00000253925PPFIA1chr1170118541+ENST00000262829RBFOX2chr2236164395-1432479651159364
ENST00000253925PPFIA1chr1170118541+ENST00000397303RBFOX2chr2236164395-1407479651159364
ENST00000253925PPFIA1chr1170118541+ENST00000359369RBFOX2chr2236164395-1414479651201378
ENST00000253925PPFIA1chr1170118541+ENST00000416721RBFOX2chr2236164395-1217479651159364
ENST00000253925PPFIA1chr1170118541+ENST00000438146RBFOX2chr2236164395-1172479651171369
ENST00000389547PPFIA1chr1170118541+ENST00000405409RBFOX2chr2236164395-6572462481112354
ENST00000389547PPFIA1chr1170118541+ENST00000414461RBFOX2chr2236164395-1718462481124358
ENST00000389547PPFIA1chr1170118541+ENST00000449924RBFOX2chr2236164395-1758462481154368
ENST00000389547PPFIA1chr1170118541+ENST00000262829RBFOX2chr2236164395-1415462481142364
ENST00000389547PPFIA1chr1170118541+ENST00000397303RBFOX2chr2236164395-1390462481142364
ENST00000389547PPFIA1chr1170118541+ENST00000359369RBFOX2chr2236164395-1397462481184378
ENST00000389547PPFIA1chr1170118541+ENST00000416721RBFOX2chr2236164395-1200462481142364
ENST00000389547PPFIA1chr1170118541+ENST00000438146RBFOX2chr2236164395-1155462481154368

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000253925ENST00000405409PPFIA1chr1170118542+RBFOX2chr2236164396-0.0048255570.99517447
ENST00000253925ENST00000414461PPFIA1chr1170118542+RBFOX2chr2236164396-0.0102714520.98972857
ENST00000253925ENST00000449924PPFIA1chr1170118542+RBFOX2chr2236164396-0.0027526380.9972473
ENST00000253925ENST00000262829PPFIA1chr1170118542+RBFOX2chr2236164396-0.0027763010.99722373
ENST00000253925ENST00000397303PPFIA1chr1170118542+RBFOX2chr2236164396-0.0032109490.9967891
ENST00000253925ENST00000359369PPFIA1chr1170118542+RBFOX2chr2236164396-0.0080339630.991966
ENST00000253925ENST00000416721PPFIA1chr1170118542+RBFOX2chr2236164396-0.0040702110.9959298
ENST00000253925ENST00000438146PPFIA1chr1170118542+RBFOX2chr2236164396-0.0037011250.99629885
ENST00000389547ENST00000405409PPFIA1chr1170118542+RBFOX2chr2236164396-0.0047476420.9952524
ENST00000389547ENST00000414461PPFIA1chr1170118542+RBFOX2chr2236164396-0.0098057470.99019426
ENST00000389547ENST00000449924PPFIA1chr1170118542+RBFOX2chr2236164396-0.0025272260.9974727
ENST00000389547ENST00000262829PPFIA1chr1170118542+RBFOX2chr2236164396-0.0026390160.997361
ENST00000389547ENST00000397303PPFIA1chr1170118542+RBFOX2chr2236164396-0.0031154820.9968845
ENST00000389547ENST00000359369PPFIA1chr1170118542+RBFOX2chr2236164396-0.007704610.9922954
ENST00000389547ENST00000416721PPFIA1chr1170118542+RBFOX2chr2236164396-0.0039537470.99604625
ENST00000389547ENST00000438146PPFIA1chr1170118542+RBFOX2chr2236164396-0.0035446820.9964553
ENST00000253925ENST00000405409PPFIA1chr1170118542+RBFOX2chr2236161530-0.002931390.9970686
ENST00000253925ENST00000414461PPFIA1chr1170118542+RBFOX2chr2236161530-0.0044241610.9955759
ENST00000253925ENST00000449924PPFIA1chr1170118542+RBFOX2chr2236161530-0.0011468240.9988532
ENST00000253925ENST00000262829PPFIA1chr1170118542+RBFOX2chr2236161530-0.0018862970.99811375
ENST00000253925ENST00000397303PPFIA1chr1170118542+RBFOX2chr2236161530-0.0021490090.997851
ENST00000253925ENST00000359369PPFIA1chr1170118542+RBFOX2chr2236161530-0.0053589540.99464107
ENST00000253925ENST00000416721PPFIA1chr1170118542+RBFOX2chr2236161530-0.0022220590.997778
ENST00000253925ENST00000438146PPFIA1chr1170118542+RBFOX2chr2236161530-0.0014540960.9985459
ENST00000389547ENST00000405409PPFIA1chr1170118542+RBFOX2chr2236161530-0.002888610.9971113
ENST00000389547ENST00000414461PPFIA1chr1170118542+RBFOX2chr2236161530-0.0040524210.99594766
ENST00000389547ENST00000449924PPFIA1chr1170118542+RBFOX2chr2236161530-0.0010863430.99891365
ENST00000389547ENST00000262829PPFIA1chr1170118542+RBFOX2chr2236161530-0.0017802680.99821967
ENST00000389547ENST00000397303PPFIA1chr1170118542+RBFOX2chr2236161530-0.0021337210.99786633
ENST00000389547ENST00000359369PPFIA1chr1170118542+RBFOX2chr2236161530-0.0053909550.994609
ENST00000389547ENST00000416721PPFIA1chr1170118542+RBFOX2chr2236161530-0.0021489350.99785113
ENST00000389547ENST00000438146PPFIA1chr1170118542+RBFOX2chr2236161530-0.0014153010.99858475
ENST00000253925ENST00000405409PPFIA1chr1170118541+RBFOX2chr2236164395-0.0048255570.99517447
ENST00000253925ENST00000414461PPFIA1chr1170118541+RBFOX2chr2236164395-0.0102714520.98972857
ENST00000253925ENST00000449924PPFIA1chr1170118541+RBFOX2chr2236164395-0.0027526380.9972473
ENST00000253925ENST00000262829PPFIA1chr1170118541+RBFOX2chr2236164395-0.0027763010.99722373
ENST00000253925ENST00000397303PPFIA1chr1170118541+RBFOX2chr2236164395-0.0032109490.9967891
ENST00000253925ENST00000359369PPFIA1chr1170118541+RBFOX2chr2236164395-0.0080339630.991966
ENST00000253925ENST00000416721PPFIA1chr1170118541+RBFOX2chr2236164395-0.0040702110.9959298
ENST00000253925ENST00000438146PPFIA1chr1170118541+RBFOX2chr2236164395-0.0037011250.99629885
ENST00000389547ENST00000405409PPFIA1chr1170118541+RBFOX2chr2236164395-0.0047476420.9952524
ENST00000389547ENST00000414461PPFIA1chr1170118541+RBFOX2chr2236164395-0.0098057470.99019426
ENST00000389547ENST00000449924PPFIA1chr1170118541+RBFOX2chr2236164395-0.0025272260.9974727
ENST00000389547ENST00000262829PPFIA1chr1170118541+RBFOX2chr2236164395-0.0026390160.997361
ENST00000389547ENST00000397303PPFIA1chr1170118541+RBFOX2chr2236164395-0.0031154820.9968845
ENST00000389547ENST00000359369PPFIA1chr1170118541+RBFOX2chr2236164395-0.007704610.9922954
ENST00000389547ENST00000416721PPFIA1chr1170118541+RBFOX2chr2236164395-0.0039537470.99604625
ENST00000389547ENST00000438146PPFIA1chr1170118541+RBFOX2chr2236164395-0.0035446820.9964553

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>67412_67412_1_PPFIA1-RBFOX2_PPFIA1_chr11_70118541_ENST00000253925_RBFOX2_chr22_36164395_ENST00000262829_length(amino acids)=364AA_BP=137
MGRRAPGPRRGAGRRTPAAGCFRRLPSSPGASSRPRAAAEPPRPLPPASKMMCEVMPTISEAEGPPGGGGGHGSGSPSQPDADSHFEQLM
VSMLEERDRLLDTLRETQETLALTQGKLHEVGHERDSLQRQLNTALPQGFGFVTFENSADADRAREKLHGTVVEGRKIEVNNATARVMTN
KKMVTPYANGWKLSPVVGAVYGPELYAASSFQADVSLGNDAAVPLSGRGGINTYIPLIIPGFPYPTAATTAAAFRGAHLRGRGRTVYGAV
RAVPPTAIPAYPGVVYQDGFYGADLYGGYAAYRYAQPATATAATAAAAAAAAYSDGYGRVYTADPYHALAPAASYGVGAVASLYRGGYSR

--------------------------------------------------------------

>67412_67412_2_PPFIA1-RBFOX2_PPFIA1_chr11_70118541_ENST00000253925_RBFOX2_chr22_36164395_ENST00000359369_length(amino acids)=378AA_BP=137
MGRRAPGPRRGAGRRTPAAGCFRRLPSSPGASSRPRAAAEPPRPLPPASKMMCEVMPTISEAEGPPGGGGGHGSGSPSQPDADSHFEQLM
VSMLEERDRLLDTLRETQETLALTQGKLHEVGHERDSLQRQLNTALPQGFGFVTFENSADADRAREKLHGTVVEGRKIEVNNATARVMTN
KKMVTPYANGWKLSPVVGAVYGPELYAASSFQADVSLGNDAAVPLSGRGGINTYIPLIIPGFPYPTAATTAAAFRGAHLRGRGRTVYGAV
RAVPPTAIPAYPGVVYQDGFYGADLYIESANCFRSNRVDMQPTDMHSLLLQPQPPLLQPLQPLTVTVMAGCTQPTPTMPLPLPLAMELAL

--------------------------------------------------------------

>67412_67412_3_PPFIA1-RBFOX2_PPFIA1_chr11_70118541_ENST00000253925_RBFOX2_chr22_36164395_ENST00000397303_length(amino acids)=364AA_BP=137
MGRRAPGPRRGAGRRTPAAGCFRRLPSSPGASSRPRAAAEPPRPLPPASKMMCEVMPTISEAEGPPGGGGGHGSGSPSQPDADSHFEQLM
VSMLEERDRLLDTLRETQETLALTQGKLHEVGHERDSLQRQLNTALPQGFGFVTFENSADADRAREKLHGTVVEGRKIEVNNATARVMTN
KKMVTPYANGWKLSPVVGAVYGPELYAASSFQADVSLGNDAAVPLSGRGGINTYIPLIIPGFPYPTAATTAAAFRGAHLRGRGRTVYGAV
RAVPPTAIPAYPGVVYQDGFYGADLYGGYAAYRYAQPATATAATAAAAAAAAYSDGYGRVYTADPYHALAPAASYGVGAVASLYRGGYSR

--------------------------------------------------------------

>67412_67412_4_PPFIA1-RBFOX2_PPFIA1_chr11_70118541_ENST00000253925_RBFOX2_chr22_36164395_ENST00000405409_length(amino acids)=354AA_BP=137
MGRRAPGPRRGAGRRTPAAGCFRRLPSSPGASSRPRAAAEPPRPLPPASKMMCEVMPTISEAEGPPGGGGGHGSGSPSQPDADSHFEQLM
VSMLEERDRLLDTLRETQETLALTQGKLHEVGHERDSLQRQLNTALPQGFGFVTFENSADADRAREKLHGTVVEGRKIEVNNATARVMTN
KKMVTPYANGWKLSPVVGAVYGPELYAASSFQADVSLGNDAAVPLSGRGGINTYIPLIIPGFPYPTAATTAAAFRGAHLRGRGRTVYGAV

--------------------------------------------------------------

>67412_67412_5_PPFIA1-RBFOX2_PPFIA1_chr11_70118541_ENST00000253925_RBFOX2_chr22_36164395_ENST00000414461_length(amino acids)=358AA_BP=137
MGRRAPGPRRGAGRRTPAAGCFRRLPSSPGASSRPRAAAEPPRPLPPASKMMCEVMPTISEAEGPPGGGGGHGSGSPSQPDADSHFEQLM
VSMLEERDRLLDTLRETQETLALTQGKLHEVGHERDSLQRQLNTALPQGFGFVTFENSADADRAREKLHGTVVEGRKIEVNNATARVMTN
KKMVTPYANGWKLSPVVGAVYGPELYAASSFQADVSLGNDAAVPLSGRGGINTYIPLISLPLVPGFPYPTAATTAAAFRGAHLRGRGRTV

--------------------------------------------------------------

>67412_67412_6_PPFIA1-RBFOX2_PPFIA1_chr11_70118541_ENST00000253925_RBFOX2_chr22_36164395_ENST00000416721_length(amino acids)=364AA_BP=137
MGRRAPGPRRGAGRRTPAAGCFRRLPSSPGASSRPRAAAEPPRPLPPASKMMCEVMPTISEAEGPPGGGGGHGSGSPSQPDADSHFEQLM
VSMLEERDRLLDTLRETQETLALTQGKLHEVGHERDSLQRQLNTALPQGFGFVTFENSADADRAREKLHGTVVEGRKIEVNNATARVMTN
KKMVTPYANGWKLSPVVGAVYGPELYAASSFQADVSLGNDAAVPLSGRGGINTYIPLIIPGFPYPTAATTAAAFRGAHLRGRGRTVYGAV
RAVPPTAIPAYPGVVYQDGFYGADLYGGYAAYRYAQPATATAATAAAAAAAAYSDGYGRVYTADPYHALAPAASYGVGAVASLYRGGYSR

--------------------------------------------------------------

>67412_67412_7_PPFIA1-RBFOX2_PPFIA1_chr11_70118541_ENST00000253925_RBFOX2_chr22_36164395_ENST00000438146_length(amino acids)=369AA_BP=137
MGRRAPGPRRGAGRRTPAAGCFRRLPSSPGASSRPRAAAEPPRPLPPASKMMCEVMPTISEAEGPPGGGGGHGSGSPSQPDADSHFEQLM
VSMLEERDRLLDTLRETQETLALTQGKLHEVGHERDSLQRQLNTALPQGFGFVTFENSADADRAREKLHGTVVEGRKIEVNNATARVMTN
KKMVTPYANGWKLSPVVGAVYGPELYAASSFQADVSLGNDAAVPLSGRGGINTYIPLISLPLVPGFPYPTAATTAAAFRGAHLRGRGRTV
YGAVRAVPPTAIPAYPGVVYQDGFYGADLYGGYAAYRYAQPATATAATAAAAAAAAYSDGYGRVYTADPYHALAPAASYGVGAVASLYRG

--------------------------------------------------------------

>67412_67412_8_PPFIA1-RBFOX2_PPFIA1_chr11_70118541_ENST00000253925_RBFOX2_chr22_36164395_ENST00000449924_length(amino acids)=368AA_BP=137
MGRRAPGPRRGAGRRTPAAGCFRRLPSSPGASSRPRAAAEPPRPLPPASKMMCEVMPTISEAEGPPGGGGGHGSGSPSQPDADSHFEQLM
VSMLEERDRLLDTLRETQETLALTQGKLHEVGHERDSLQRQLNTALPQGFGFVTFENSADADRAREKLHGTVVEGRKIEVNNATARVMTN
KKMVTPYANGWKLSPVVGAVYGPELYAASSFQADVSLGNDAAVPLSGRGGINTYIPLISLPLVPGFPYPTAATTAAAFRGAHLRGRGRTV
YGAVRAVPPTAIPAYPGVVYQDGFYGADLYGGYAAYRYAQPATATAATAAAAAAAAYSDGYGRVYTADPYHALAPAASYGVGAVASLYRG

--------------------------------------------------------------

>67412_67412_9_PPFIA1-RBFOX2_PPFIA1_chr11_70118541_ENST00000389547_RBFOX2_chr22_36164395_ENST00000262829_length(amino acids)=364AA_BP=137
MGRRAPGPRRGAGRRTPAAGCFRRLPSSPGASSRPRAAAEPPRPLPPASKMMCEVMPTISEAEGPPGGGGGHGSGSPSQPDADSHFEQLM
VSMLEERDRLLDTLRETQETLALTQGKLHEVGHERDSLQRQLNTALPQGFGFVTFENSADADRAREKLHGTVVEGRKIEVNNATARVMTN
KKMVTPYANGWKLSPVVGAVYGPELYAASSFQADVSLGNDAAVPLSGRGGINTYIPLIIPGFPYPTAATTAAAFRGAHLRGRGRTVYGAV
RAVPPTAIPAYPGVVYQDGFYGADLYGGYAAYRYAQPATATAATAAAAAAAAYSDGYGRVYTADPYHALAPAASYGVGAVASLYRGGYSR

--------------------------------------------------------------

>67412_67412_10_PPFIA1-RBFOX2_PPFIA1_chr11_70118541_ENST00000389547_RBFOX2_chr22_36164395_ENST00000359369_length(amino acids)=378AA_BP=137
MGRRAPGPRRGAGRRTPAAGCFRRLPSSPGASSRPRAAAEPPRPLPPASKMMCEVMPTISEAEGPPGGGGGHGSGSPSQPDADSHFEQLM
VSMLEERDRLLDTLRETQETLALTQGKLHEVGHERDSLQRQLNTALPQGFGFVTFENSADADRAREKLHGTVVEGRKIEVNNATARVMTN
KKMVTPYANGWKLSPVVGAVYGPELYAASSFQADVSLGNDAAVPLSGRGGINTYIPLIIPGFPYPTAATTAAAFRGAHLRGRGRTVYGAV
RAVPPTAIPAYPGVVYQDGFYGADLYIESANCFRSNRVDMQPTDMHSLLLQPQPPLLQPLQPLTVTVMAGCTQPTPTMPLPLPLAMELAL

--------------------------------------------------------------

>67412_67412_11_PPFIA1-RBFOX2_PPFIA1_chr11_70118541_ENST00000389547_RBFOX2_chr22_36164395_ENST00000397303_length(amino acids)=364AA_BP=137
MGRRAPGPRRGAGRRTPAAGCFRRLPSSPGASSRPRAAAEPPRPLPPASKMMCEVMPTISEAEGPPGGGGGHGSGSPSQPDADSHFEQLM
VSMLEERDRLLDTLRETQETLALTQGKLHEVGHERDSLQRQLNTALPQGFGFVTFENSADADRAREKLHGTVVEGRKIEVNNATARVMTN
KKMVTPYANGWKLSPVVGAVYGPELYAASSFQADVSLGNDAAVPLSGRGGINTYIPLIIPGFPYPTAATTAAAFRGAHLRGRGRTVYGAV
RAVPPTAIPAYPGVVYQDGFYGADLYGGYAAYRYAQPATATAATAAAAAAAAYSDGYGRVYTADPYHALAPAASYGVGAVASLYRGGYSR

--------------------------------------------------------------

>67412_67412_12_PPFIA1-RBFOX2_PPFIA1_chr11_70118541_ENST00000389547_RBFOX2_chr22_36164395_ENST00000405409_length(amino acids)=354AA_BP=137
MGRRAPGPRRGAGRRTPAAGCFRRLPSSPGASSRPRAAAEPPRPLPPASKMMCEVMPTISEAEGPPGGGGGHGSGSPSQPDADSHFEQLM
VSMLEERDRLLDTLRETQETLALTQGKLHEVGHERDSLQRQLNTALPQGFGFVTFENSADADRAREKLHGTVVEGRKIEVNNATARVMTN
KKMVTPYANGWKLSPVVGAVYGPELYAASSFQADVSLGNDAAVPLSGRGGINTYIPLIIPGFPYPTAATTAAAFRGAHLRGRGRTVYGAV

--------------------------------------------------------------

>67412_67412_13_PPFIA1-RBFOX2_PPFIA1_chr11_70118541_ENST00000389547_RBFOX2_chr22_36164395_ENST00000414461_length(amino acids)=358AA_BP=137
MGRRAPGPRRGAGRRTPAAGCFRRLPSSPGASSRPRAAAEPPRPLPPASKMMCEVMPTISEAEGPPGGGGGHGSGSPSQPDADSHFEQLM
VSMLEERDRLLDTLRETQETLALTQGKLHEVGHERDSLQRQLNTALPQGFGFVTFENSADADRAREKLHGTVVEGRKIEVNNATARVMTN
KKMVTPYANGWKLSPVVGAVYGPELYAASSFQADVSLGNDAAVPLSGRGGINTYIPLISLPLVPGFPYPTAATTAAAFRGAHLRGRGRTV

--------------------------------------------------------------

>67412_67412_14_PPFIA1-RBFOX2_PPFIA1_chr11_70118541_ENST00000389547_RBFOX2_chr22_36164395_ENST00000416721_length(amino acids)=364AA_BP=137
MGRRAPGPRRGAGRRTPAAGCFRRLPSSPGASSRPRAAAEPPRPLPPASKMMCEVMPTISEAEGPPGGGGGHGSGSPSQPDADSHFEQLM
VSMLEERDRLLDTLRETQETLALTQGKLHEVGHERDSLQRQLNTALPQGFGFVTFENSADADRAREKLHGTVVEGRKIEVNNATARVMTN
KKMVTPYANGWKLSPVVGAVYGPELYAASSFQADVSLGNDAAVPLSGRGGINTYIPLIIPGFPYPTAATTAAAFRGAHLRGRGRTVYGAV
RAVPPTAIPAYPGVVYQDGFYGADLYGGYAAYRYAQPATATAATAAAAAAAAYSDGYGRVYTADPYHALAPAASYGVGAVASLYRGGYSR

--------------------------------------------------------------

>67412_67412_15_PPFIA1-RBFOX2_PPFIA1_chr11_70118541_ENST00000389547_RBFOX2_chr22_36164395_ENST00000438146_length(amino acids)=368AA_BP=137
MGRRAPGPRRGAGRRTPAAGCFRRLPSSPGASSRPRAAAEPPRPLPPASKMMCEVMPTISEAEGPPGGGGGHGSGSPSQPDADSHFEQLM
VSMLEERDRLLDTLRETQETLALTQGKLHEVGHERDSLQRQLNTALPQGFGFVTFENSADADRAREKLHGTVVEGRKIEVNNATARVMTN
KKMVTPYANGWKLSPVVGAVYGPELYAASSFQADVSLGNDAAVPLSGRGGINTYIPLISLPLVPGFPYPTAATTAAAFRGAHLRGRGRTV
YGAVRAVPPTAIPAYPGVVYQDGFYGADLYGGYAAYRYAQPATATAATAAAAAAAAYSDGYGRVYTADPYHALAPAASYGVGAVASLYRG

--------------------------------------------------------------

>67412_67412_16_PPFIA1-RBFOX2_PPFIA1_chr11_70118541_ENST00000389547_RBFOX2_chr22_36164395_ENST00000449924_length(amino acids)=368AA_BP=137
MGRRAPGPRRGAGRRTPAAGCFRRLPSSPGASSRPRAAAEPPRPLPPASKMMCEVMPTISEAEGPPGGGGGHGSGSPSQPDADSHFEQLM
VSMLEERDRLLDTLRETQETLALTQGKLHEVGHERDSLQRQLNTALPQGFGFVTFENSADADRAREKLHGTVVEGRKIEVNNATARVMTN
KKMVTPYANGWKLSPVVGAVYGPELYAASSFQADVSLGNDAAVPLSGRGGINTYIPLISLPLVPGFPYPTAATTAAAFRGAHLRGRGRTV
YGAVRAVPPTAIPAYPGVVYQDGFYGADLYGGYAAYRYAQPATATAATAAAAAAAAYSDGYGRVYTADPYHALAPAASYGVGAVASLYRG

--------------------------------------------------------------

>67412_67412_17_PPFIA1-RBFOX2_PPFIA1_chr11_70118542_ENST00000253925_RBFOX2_chr22_36161530_ENST00000262829_length(amino acids)=333AA_BP=138
MGRRAPGPRRGAGRRTPAAGCFRRLPSSPGASSRPRAAAEPPRPLPPASKMMCEVMPTISEAEGPPGGGGGHGSGSPSQPDADSHFEQLM
VSMLEERDRLLDTLRETQETLALTQGKLHEVGHERDSLQRQLNTALPQVNNATARVMTNKKMVTPYANGWKLSPVVGAVYGPELYAASSF
QADVSLGNDAAVPLSGRGGINTYIPLIIPGFPYPTAATTAAAFRGAHLRGRGRTVYGAVRAVPPTAIPAYPGVVYQDGFYGADLYGGYAA

--------------------------------------------------------------

>67412_67412_18_PPFIA1-RBFOX2_PPFIA1_chr11_70118542_ENST00000253925_RBFOX2_chr22_36161530_ENST00000359369_length(amino acids)=347AA_BP=138
MGRRAPGPRRGAGRRTPAAGCFRRLPSSPGASSRPRAAAEPPRPLPPASKMMCEVMPTISEAEGPPGGGGGHGSGSPSQPDADSHFEQLM
VSMLEERDRLLDTLRETQETLALTQGKLHEVGHERDSLQRQLNTALPQVNNATARVMTNKKMVTPYANGWKLSPVVGAVYGPELYAASSF
QADVSLGNDAAVPLSGRGGINTYIPLIIPGFPYPTAATTAAAFRGAHLRGRGRTVYGAVRAVPPTAIPAYPGVVYQDGFYGADLYIESAN

--------------------------------------------------------------

>67412_67412_19_PPFIA1-RBFOX2_PPFIA1_chr11_70118542_ENST00000253925_RBFOX2_chr22_36161530_ENST00000397303_length(amino acids)=333AA_BP=138
MGRRAPGPRRGAGRRTPAAGCFRRLPSSPGASSRPRAAAEPPRPLPPASKMMCEVMPTISEAEGPPGGGGGHGSGSPSQPDADSHFEQLM
VSMLEERDRLLDTLRETQETLALTQGKLHEVGHERDSLQRQLNTALPQVNNATARVMTNKKMVTPYANGWKLSPVVGAVYGPELYAASSF
QADVSLGNDAAVPLSGRGGINTYIPLIIPGFPYPTAATTAAAFRGAHLRGRGRTVYGAVRAVPPTAIPAYPGVVYQDGFYGADLYGGYAA

--------------------------------------------------------------

>67412_67412_20_PPFIA1-RBFOX2_PPFIA1_chr11_70118542_ENST00000253925_RBFOX2_chr22_36161530_ENST00000405409_length(amino acids)=323AA_BP=138
MGRRAPGPRRGAGRRTPAAGCFRRLPSSPGASSRPRAAAEPPRPLPPASKMMCEVMPTISEAEGPPGGGGGHGSGSPSQPDADSHFEQLM
VSMLEERDRLLDTLRETQETLALTQGKLHEVGHERDSLQRQLNTALPQVNNATARVMTNKKMVTPYANGWKLSPVVGAVYGPELYAASSF
QADVSLGNDAAVPLSGRGGINTYIPLIIPGFPYPTAATTAAAFRGAHLRGRGRTVYGAVRAVPPTAIPAYPGVDMQPTDMHSLLLQPQPP

--------------------------------------------------------------

>67412_67412_21_PPFIA1-RBFOX2_PPFIA1_chr11_70118542_ENST00000253925_RBFOX2_chr22_36161530_ENST00000414461_length(amino acids)=327AA_BP=138
MGRRAPGPRRGAGRRTPAAGCFRRLPSSPGASSRPRAAAEPPRPLPPASKMMCEVMPTISEAEGPPGGGGGHGSGSPSQPDADSHFEQLM
VSMLEERDRLLDTLRETQETLALTQGKLHEVGHERDSLQRQLNTALPQVNNATARVMTNKKMVTPYANGWKLSPVVGAVYGPELYAASSF
QADVSLGNDAAVPLSGRGGINTYIPLISLPLVPGFPYPTAATTAAAFRGAHLRGRGRTVYGAVRAVPPTAIPAYPGVDMQPTDMHSLLLQ

--------------------------------------------------------------

>67412_67412_22_PPFIA1-RBFOX2_PPFIA1_chr11_70118542_ENST00000253925_RBFOX2_chr22_36161530_ENST00000416721_length(amino acids)=333AA_BP=138
MGRRAPGPRRGAGRRTPAAGCFRRLPSSPGASSRPRAAAEPPRPLPPASKMMCEVMPTISEAEGPPGGGGGHGSGSPSQPDADSHFEQLM
VSMLEERDRLLDTLRETQETLALTQGKLHEVGHERDSLQRQLNTALPQVNNATARVMTNKKMVTPYANGWKLSPVVGAVYGPELYAASSF
QADVSLGNDAAVPLSGRGGINTYIPLIIPGFPYPTAATTAAAFRGAHLRGRGRTVYGAVRAVPPTAIPAYPGVVYQDGFYGADLYGGYAA

--------------------------------------------------------------

>67412_67412_23_PPFIA1-RBFOX2_PPFIA1_chr11_70118542_ENST00000253925_RBFOX2_chr22_36161530_ENST00000438146_length(amino acids)=338AA_BP=138
MGRRAPGPRRGAGRRTPAAGCFRRLPSSPGASSRPRAAAEPPRPLPPASKMMCEVMPTISEAEGPPGGGGGHGSGSPSQPDADSHFEQLM
VSMLEERDRLLDTLRETQETLALTQGKLHEVGHERDSLQRQLNTALPQVNNATARVMTNKKMVTPYANGWKLSPVVGAVYGPELYAASSF
QADVSLGNDAAVPLSGRGGINTYIPLISLPLVPGFPYPTAATTAAAFRGAHLRGRGRTVYGAVRAVPPTAIPAYPGVVYQDGFYGADLYG

--------------------------------------------------------------

>67412_67412_24_PPFIA1-RBFOX2_PPFIA1_chr11_70118542_ENST00000253925_RBFOX2_chr22_36161530_ENST00000449924_length(amino acids)=337AA_BP=138
MGRRAPGPRRGAGRRTPAAGCFRRLPSSPGASSRPRAAAEPPRPLPPASKMMCEVMPTISEAEGPPGGGGGHGSGSPSQPDADSHFEQLM
VSMLEERDRLLDTLRETQETLALTQGKLHEVGHERDSLQRQLNTALPQVNNATARVMTNKKMVTPYANGWKLSPVVGAVYGPELYAASSF
QADVSLGNDAAVPLSGRGGINTYIPLISLPLVPGFPYPTAATTAAAFRGAHLRGRGRTVYGAVRAVPPTAIPAYPGVVYQDGFYGADLYG

--------------------------------------------------------------

>67412_67412_25_PPFIA1-RBFOX2_PPFIA1_chr11_70118542_ENST00000253925_RBFOX2_chr22_36164396_ENST00000262829_length(amino acids)=364AA_BP=137
MGRRAPGPRRGAGRRTPAAGCFRRLPSSPGASSRPRAAAEPPRPLPPASKMMCEVMPTISEAEGPPGGGGGHGSGSPSQPDADSHFEQLM
VSMLEERDRLLDTLRETQETLALTQGKLHEVGHERDSLQRQLNTALPQGFGFVTFENSADADRAREKLHGTVVEGRKIEVNNATARVMTN
KKMVTPYANGWKLSPVVGAVYGPELYAASSFQADVSLGNDAAVPLSGRGGINTYIPLIIPGFPYPTAATTAAAFRGAHLRGRGRTVYGAV
RAVPPTAIPAYPGVVYQDGFYGADLYGGYAAYRYAQPATATAATAAAAAAAAYSDGYGRVYTADPYHALAPAASYGVGAVASLYRGGYSR

--------------------------------------------------------------

>67412_67412_26_PPFIA1-RBFOX2_PPFIA1_chr11_70118542_ENST00000253925_RBFOX2_chr22_36164396_ENST00000359369_length(amino acids)=378AA_BP=137
MGRRAPGPRRGAGRRTPAAGCFRRLPSSPGASSRPRAAAEPPRPLPPASKMMCEVMPTISEAEGPPGGGGGHGSGSPSQPDADSHFEQLM
VSMLEERDRLLDTLRETQETLALTQGKLHEVGHERDSLQRQLNTALPQGFGFVTFENSADADRAREKLHGTVVEGRKIEVNNATARVMTN
KKMVTPYANGWKLSPVVGAVYGPELYAASSFQADVSLGNDAAVPLSGRGGINTYIPLIIPGFPYPTAATTAAAFRGAHLRGRGRTVYGAV
RAVPPTAIPAYPGVVYQDGFYGADLYIESANCFRSNRVDMQPTDMHSLLLQPQPPLLQPLQPLTVTVMAGCTQPTPTMPLPLPLAMELAL

--------------------------------------------------------------

>67412_67412_27_PPFIA1-RBFOX2_PPFIA1_chr11_70118542_ENST00000253925_RBFOX2_chr22_36164396_ENST00000397303_length(amino acids)=364AA_BP=137
MGRRAPGPRRGAGRRTPAAGCFRRLPSSPGASSRPRAAAEPPRPLPPASKMMCEVMPTISEAEGPPGGGGGHGSGSPSQPDADSHFEQLM
VSMLEERDRLLDTLRETQETLALTQGKLHEVGHERDSLQRQLNTALPQGFGFVTFENSADADRAREKLHGTVVEGRKIEVNNATARVMTN
KKMVTPYANGWKLSPVVGAVYGPELYAASSFQADVSLGNDAAVPLSGRGGINTYIPLIIPGFPYPTAATTAAAFRGAHLRGRGRTVYGAV
RAVPPTAIPAYPGVVYQDGFYGADLYGGYAAYRYAQPATATAATAAAAAAAAYSDGYGRVYTADPYHALAPAASYGVGAVASLYRGGYSR

--------------------------------------------------------------

>67412_67412_28_PPFIA1-RBFOX2_PPFIA1_chr11_70118542_ENST00000253925_RBFOX2_chr22_36164396_ENST00000405409_length(amino acids)=354AA_BP=137
MGRRAPGPRRGAGRRTPAAGCFRRLPSSPGASSRPRAAAEPPRPLPPASKMMCEVMPTISEAEGPPGGGGGHGSGSPSQPDADSHFEQLM
VSMLEERDRLLDTLRETQETLALTQGKLHEVGHERDSLQRQLNTALPQGFGFVTFENSADADRAREKLHGTVVEGRKIEVNNATARVMTN
KKMVTPYANGWKLSPVVGAVYGPELYAASSFQADVSLGNDAAVPLSGRGGINTYIPLIIPGFPYPTAATTAAAFRGAHLRGRGRTVYGAV

--------------------------------------------------------------

>67412_67412_29_PPFIA1-RBFOX2_PPFIA1_chr11_70118542_ENST00000253925_RBFOX2_chr22_36164396_ENST00000414461_length(amino acids)=358AA_BP=137
MGRRAPGPRRGAGRRTPAAGCFRRLPSSPGASSRPRAAAEPPRPLPPASKMMCEVMPTISEAEGPPGGGGGHGSGSPSQPDADSHFEQLM
VSMLEERDRLLDTLRETQETLALTQGKLHEVGHERDSLQRQLNTALPQGFGFVTFENSADADRAREKLHGTVVEGRKIEVNNATARVMTN
KKMVTPYANGWKLSPVVGAVYGPELYAASSFQADVSLGNDAAVPLSGRGGINTYIPLISLPLVPGFPYPTAATTAAAFRGAHLRGRGRTV

--------------------------------------------------------------

>67412_67412_30_PPFIA1-RBFOX2_PPFIA1_chr11_70118542_ENST00000253925_RBFOX2_chr22_36164396_ENST00000416721_length(amino acids)=364AA_BP=137
MGRRAPGPRRGAGRRTPAAGCFRRLPSSPGASSRPRAAAEPPRPLPPASKMMCEVMPTISEAEGPPGGGGGHGSGSPSQPDADSHFEQLM
VSMLEERDRLLDTLRETQETLALTQGKLHEVGHERDSLQRQLNTALPQGFGFVTFENSADADRAREKLHGTVVEGRKIEVNNATARVMTN
KKMVTPYANGWKLSPVVGAVYGPELYAASSFQADVSLGNDAAVPLSGRGGINTYIPLIIPGFPYPTAATTAAAFRGAHLRGRGRTVYGAV
RAVPPTAIPAYPGVVYQDGFYGADLYGGYAAYRYAQPATATAATAAAAAAAAYSDGYGRVYTADPYHALAPAASYGVGAVASLYRGGYSR

--------------------------------------------------------------

>67412_67412_31_PPFIA1-RBFOX2_PPFIA1_chr11_70118542_ENST00000253925_RBFOX2_chr22_36164396_ENST00000438146_length(amino acids)=369AA_BP=137
MGRRAPGPRRGAGRRTPAAGCFRRLPSSPGASSRPRAAAEPPRPLPPASKMMCEVMPTISEAEGPPGGGGGHGSGSPSQPDADSHFEQLM
VSMLEERDRLLDTLRETQETLALTQGKLHEVGHERDSLQRQLNTALPQGFGFVTFENSADADRAREKLHGTVVEGRKIEVNNATARVMTN
KKMVTPYANGWKLSPVVGAVYGPELYAASSFQADVSLGNDAAVPLSGRGGINTYIPLISLPLVPGFPYPTAATTAAAFRGAHLRGRGRTV
YGAVRAVPPTAIPAYPGVVYQDGFYGADLYGGYAAYRYAQPATATAATAAAAAAAAYSDGYGRVYTADPYHALAPAASYGVGAVASLYRG

--------------------------------------------------------------

>67412_67412_32_PPFIA1-RBFOX2_PPFIA1_chr11_70118542_ENST00000253925_RBFOX2_chr22_36164396_ENST00000449924_length(amino acids)=368AA_BP=137
MGRRAPGPRRGAGRRTPAAGCFRRLPSSPGASSRPRAAAEPPRPLPPASKMMCEVMPTISEAEGPPGGGGGHGSGSPSQPDADSHFEQLM
VSMLEERDRLLDTLRETQETLALTQGKLHEVGHERDSLQRQLNTALPQGFGFVTFENSADADRAREKLHGTVVEGRKIEVNNATARVMTN
KKMVTPYANGWKLSPVVGAVYGPELYAASSFQADVSLGNDAAVPLSGRGGINTYIPLISLPLVPGFPYPTAATTAAAFRGAHLRGRGRTV
YGAVRAVPPTAIPAYPGVVYQDGFYGADLYGGYAAYRYAQPATATAATAAAAAAAAYSDGYGRVYTADPYHALAPAASYGVGAVASLYRG

--------------------------------------------------------------

>67412_67412_33_PPFIA1-RBFOX2_PPFIA1_chr11_70118542_ENST00000389547_RBFOX2_chr22_36161530_ENST00000262829_length(amino acids)=333AA_BP=138
MGRRAPGPRRGAGRRTPAAGCFRRLPSSPGASSRPRAAAEPPRPLPPASKMMCEVMPTISEAEGPPGGGGGHGSGSPSQPDADSHFEQLM
VSMLEERDRLLDTLRETQETLALTQGKLHEVGHERDSLQRQLNTALPQVNNATARVMTNKKMVTPYANGWKLSPVVGAVYGPELYAASSF
QADVSLGNDAAVPLSGRGGINTYIPLIIPGFPYPTAATTAAAFRGAHLRGRGRTVYGAVRAVPPTAIPAYPGVVYQDGFYGADLYGGYAA

--------------------------------------------------------------

>67412_67412_34_PPFIA1-RBFOX2_PPFIA1_chr11_70118542_ENST00000389547_RBFOX2_chr22_36161530_ENST00000359369_length(amino acids)=347AA_BP=138
MGRRAPGPRRGAGRRTPAAGCFRRLPSSPGASSRPRAAAEPPRPLPPASKMMCEVMPTISEAEGPPGGGGGHGSGSPSQPDADSHFEQLM
VSMLEERDRLLDTLRETQETLALTQGKLHEVGHERDSLQRQLNTALPQVNNATARVMTNKKMVTPYANGWKLSPVVGAVYGPELYAASSF
QADVSLGNDAAVPLSGRGGINTYIPLIIPGFPYPTAATTAAAFRGAHLRGRGRTVYGAVRAVPPTAIPAYPGVVYQDGFYGADLYIESAN

--------------------------------------------------------------

>67412_67412_35_PPFIA1-RBFOX2_PPFIA1_chr11_70118542_ENST00000389547_RBFOX2_chr22_36161530_ENST00000397303_length(amino acids)=333AA_BP=138
MGRRAPGPRRGAGRRTPAAGCFRRLPSSPGASSRPRAAAEPPRPLPPASKMMCEVMPTISEAEGPPGGGGGHGSGSPSQPDADSHFEQLM
VSMLEERDRLLDTLRETQETLALTQGKLHEVGHERDSLQRQLNTALPQVNNATARVMTNKKMVTPYANGWKLSPVVGAVYGPELYAASSF
QADVSLGNDAAVPLSGRGGINTYIPLIIPGFPYPTAATTAAAFRGAHLRGRGRTVYGAVRAVPPTAIPAYPGVVYQDGFYGADLYGGYAA

--------------------------------------------------------------

>67412_67412_36_PPFIA1-RBFOX2_PPFIA1_chr11_70118542_ENST00000389547_RBFOX2_chr22_36161530_ENST00000405409_length(amino acids)=323AA_BP=138
MGRRAPGPRRGAGRRTPAAGCFRRLPSSPGASSRPRAAAEPPRPLPPASKMMCEVMPTISEAEGPPGGGGGHGSGSPSQPDADSHFEQLM
VSMLEERDRLLDTLRETQETLALTQGKLHEVGHERDSLQRQLNTALPQVNNATARVMTNKKMVTPYANGWKLSPVVGAVYGPELYAASSF
QADVSLGNDAAVPLSGRGGINTYIPLIIPGFPYPTAATTAAAFRGAHLRGRGRTVYGAVRAVPPTAIPAYPGVDMQPTDMHSLLLQPQPP

--------------------------------------------------------------

>67412_67412_37_PPFIA1-RBFOX2_PPFIA1_chr11_70118542_ENST00000389547_RBFOX2_chr22_36161530_ENST00000414461_length(amino acids)=327AA_BP=138
MGRRAPGPRRGAGRRTPAAGCFRRLPSSPGASSRPRAAAEPPRPLPPASKMMCEVMPTISEAEGPPGGGGGHGSGSPSQPDADSHFEQLM
VSMLEERDRLLDTLRETQETLALTQGKLHEVGHERDSLQRQLNTALPQVNNATARVMTNKKMVTPYANGWKLSPVVGAVYGPELYAASSF
QADVSLGNDAAVPLSGRGGINTYIPLISLPLVPGFPYPTAATTAAAFRGAHLRGRGRTVYGAVRAVPPTAIPAYPGVDMQPTDMHSLLLQ

--------------------------------------------------------------

>67412_67412_38_PPFIA1-RBFOX2_PPFIA1_chr11_70118542_ENST00000389547_RBFOX2_chr22_36161530_ENST00000416721_length(amino acids)=333AA_BP=138
MGRRAPGPRRGAGRRTPAAGCFRRLPSSPGASSRPRAAAEPPRPLPPASKMMCEVMPTISEAEGPPGGGGGHGSGSPSQPDADSHFEQLM
VSMLEERDRLLDTLRETQETLALTQGKLHEVGHERDSLQRQLNTALPQVNNATARVMTNKKMVTPYANGWKLSPVVGAVYGPELYAASSF
QADVSLGNDAAVPLSGRGGINTYIPLIIPGFPYPTAATTAAAFRGAHLRGRGRTVYGAVRAVPPTAIPAYPGVVYQDGFYGADLYGGYAA

--------------------------------------------------------------

>67412_67412_39_PPFIA1-RBFOX2_PPFIA1_chr11_70118542_ENST00000389547_RBFOX2_chr22_36161530_ENST00000438146_length(amino acids)=337AA_BP=138
MGRRAPGPRRGAGRRTPAAGCFRRLPSSPGASSRPRAAAEPPRPLPPASKMMCEVMPTISEAEGPPGGGGGHGSGSPSQPDADSHFEQLM
VSMLEERDRLLDTLRETQETLALTQGKLHEVGHERDSLQRQLNTALPQVNNATARVMTNKKMVTPYANGWKLSPVVGAVYGPELYAASSF
QADVSLGNDAAVPLSGRGGINTYIPLISLPLVPGFPYPTAATTAAAFRGAHLRGRGRTVYGAVRAVPPTAIPAYPGVVYQDGFYGADLYG

--------------------------------------------------------------

>67412_67412_40_PPFIA1-RBFOX2_PPFIA1_chr11_70118542_ENST00000389547_RBFOX2_chr22_36161530_ENST00000449924_length(amino acids)=337AA_BP=138
MGRRAPGPRRGAGRRTPAAGCFRRLPSSPGASSRPRAAAEPPRPLPPASKMMCEVMPTISEAEGPPGGGGGHGSGSPSQPDADSHFEQLM
VSMLEERDRLLDTLRETQETLALTQGKLHEVGHERDSLQRQLNTALPQVNNATARVMTNKKMVTPYANGWKLSPVVGAVYGPELYAASSF
QADVSLGNDAAVPLSGRGGINTYIPLISLPLVPGFPYPTAATTAAAFRGAHLRGRGRTVYGAVRAVPPTAIPAYPGVVYQDGFYGADLYG

--------------------------------------------------------------

>67412_67412_41_PPFIA1-RBFOX2_PPFIA1_chr11_70118542_ENST00000389547_RBFOX2_chr22_36164396_ENST00000262829_length(amino acids)=364AA_BP=137
MGRRAPGPRRGAGRRTPAAGCFRRLPSSPGASSRPRAAAEPPRPLPPASKMMCEVMPTISEAEGPPGGGGGHGSGSPSQPDADSHFEQLM
VSMLEERDRLLDTLRETQETLALTQGKLHEVGHERDSLQRQLNTALPQGFGFVTFENSADADRAREKLHGTVVEGRKIEVNNATARVMTN
KKMVTPYANGWKLSPVVGAVYGPELYAASSFQADVSLGNDAAVPLSGRGGINTYIPLIIPGFPYPTAATTAAAFRGAHLRGRGRTVYGAV
RAVPPTAIPAYPGVVYQDGFYGADLYGGYAAYRYAQPATATAATAAAAAAAAYSDGYGRVYTADPYHALAPAASYGVGAVASLYRGGYSR

--------------------------------------------------------------

>67412_67412_42_PPFIA1-RBFOX2_PPFIA1_chr11_70118542_ENST00000389547_RBFOX2_chr22_36164396_ENST00000359369_length(amino acids)=378AA_BP=137
MGRRAPGPRRGAGRRTPAAGCFRRLPSSPGASSRPRAAAEPPRPLPPASKMMCEVMPTISEAEGPPGGGGGHGSGSPSQPDADSHFEQLM
VSMLEERDRLLDTLRETQETLALTQGKLHEVGHERDSLQRQLNTALPQGFGFVTFENSADADRAREKLHGTVVEGRKIEVNNATARVMTN
KKMVTPYANGWKLSPVVGAVYGPELYAASSFQADVSLGNDAAVPLSGRGGINTYIPLIIPGFPYPTAATTAAAFRGAHLRGRGRTVYGAV
RAVPPTAIPAYPGVVYQDGFYGADLYIESANCFRSNRVDMQPTDMHSLLLQPQPPLLQPLQPLTVTVMAGCTQPTPTMPLPLPLAMELAL

--------------------------------------------------------------

>67412_67412_43_PPFIA1-RBFOX2_PPFIA1_chr11_70118542_ENST00000389547_RBFOX2_chr22_36164396_ENST00000397303_length(amino acids)=364AA_BP=137
MGRRAPGPRRGAGRRTPAAGCFRRLPSSPGASSRPRAAAEPPRPLPPASKMMCEVMPTISEAEGPPGGGGGHGSGSPSQPDADSHFEQLM
VSMLEERDRLLDTLRETQETLALTQGKLHEVGHERDSLQRQLNTALPQGFGFVTFENSADADRAREKLHGTVVEGRKIEVNNATARVMTN
KKMVTPYANGWKLSPVVGAVYGPELYAASSFQADVSLGNDAAVPLSGRGGINTYIPLIIPGFPYPTAATTAAAFRGAHLRGRGRTVYGAV
RAVPPTAIPAYPGVVYQDGFYGADLYGGYAAYRYAQPATATAATAAAAAAAAYSDGYGRVYTADPYHALAPAASYGVGAVASLYRGGYSR

--------------------------------------------------------------

>67412_67412_44_PPFIA1-RBFOX2_PPFIA1_chr11_70118542_ENST00000389547_RBFOX2_chr22_36164396_ENST00000405409_length(amino acids)=354AA_BP=137
MGRRAPGPRRGAGRRTPAAGCFRRLPSSPGASSRPRAAAEPPRPLPPASKMMCEVMPTISEAEGPPGGGGGHGSGSPSQPDADSHFEQLM
VSMLEERDRLLDTLRETQETLALTQGKLHEVGHERDSLQRQLNTALPQGFGFVTFENSADADRAREKLHGTVVEGRKIEVNNATARVMTN
KKMVTPYANGWKLSPVVGAVYGPELYAASSFQADVSLGNDAAVPLSGRGGINTYIPLIIPGFPYPTAATTAAAFRGAHLRGRGRTVYGAV

--------------------------------------------------------------

>67412_67412_45_PPFIA1-RBFOX2_PPFIA1_chr11_70118542_ENST00000389547_RBFOX2_chr22_36164396_ENST00000414461_length(amino acids)=358AA_BP=137
MGRRAPGPRRGAGRRTPAAGCFRRLPSSPGASSRPRAAAEPPRPLPPASKMMCEVMPTISEAEGPPGGGGGHGSGSPSQPDADSHFEQLM
VSMLEERDRLLDTLRETQETLALTQGKLHEVGHERDSLQRQLNTALPQGFGFVTFENSADADRAREKLHGTVVEGRKIEVNNATARVMTN
KKMVTPYANGWKLSPVVGAVYGPELYAASSFQADVSLGNDAAVPLSGRGGINTYIPLISLPLVPGFPYPTAATTAAAFRGAHLRGRGRTV

--------------------------------------------------------------

>67412_67412_46_PPFIA1-RBFOX2_PPFIA1_chr11_70118542_ENST00000389547_RBFOX2_chr22_36164396_ENST00000416721_length(amino acids)=364AA_BP=137
MGRRAPGPRRGAGRRTPAAGCFRRLPSSPGASSRPRAAAEPPRPLPPASKMMCEVMPTISEAEGPPGGGGGHGSGSPSQPDADSHFEQLM
VSMLEERDRLLDTLRETQETLALTQGKLHEVGHERDSLQRQLNTALPQGFGFVTFENSADADRAREKLHGTVVEGRKIEVNNATARVMTN
KKMVTPYANGWKLSPVVGAVYGPELYAASSFQADVSLGNDAAVPLSGRGGINTYIPLIIPGFPYPTAATTAAAFRGAHLRGRGRTVYGAV
RAVPPTAIPAYPGVVYQDGFYGADLYGGYAAYRYAQPATATAATAAAAAAAAYSDGYGRVYTADPYHALAPAASYGVGAVASLYRGGYSR

--------------------------------------------------------------

>67412_67412_47_PPFIA1-RBFOX2_PPFIA1_chr11_70118542_ENST00000389547_RBFOX2_chr22_36164396_ENST00000438146_length(amino acids)=368AA_BP=137
MGRRAPGPRRGAGRRTPAAGCFRRLPSSPGASSRPRAAAEPPRPLPPASKMMCEVMPTISEAEGPPGGGGGHGSGSPSQPDADSHFEQLM
VSMLEERDRLLDTLRETQETLALTQGKLHEVGHERDSLQRQLNTALPQGFGFVTFENSADADRAREKLHGTVVEGRKIEVNNATARVMTN
KKMVTPYANGWKLSPVVGAVYGPELYAASSFQADVSLGNDAAVPLSGRGGINTYIPLISLPLVPGFPYPTAATTAAAFRGAHLRGRGRTV
YGAVRAVPPTAIPAYPGVVYQDGFYGADLYGGYAAYRYAQPATATAATAAAAAAAAYSDGYGRVYTADPYHALAPAASYGVGAVASLYRG

--------------------------------------------------------------

>67412_67412_48_PPFIA1-RBFOX2_PPFIA1_chr11_70118542_ENST00000389547_RBFOX2_chr22_36164396_ENST00000449924_length(amino acids)=368AA_BP=137
MGRRAPGPRRGAGRRTPAAGCFRRLPSSPGASSRPRAAAEPPRPLPPASKMMCEVMPTISEAEGPPGGGGGHGSGSPSQPDADSHFEQLM
VSMLEERDRLLDTLRETQETLALTQGKLHEVGHERDSLQRQLNTALPQGFGFVTFENSADADRAREKLHGTVVEGRKIEVNNATARVMTN
KKMVTPYANGWKLSPVVGAVYGPELYAASSFQADVSLGNDAAVPLSGRGGINTYIPLISLPLVPGFPYPTAATTAAAFRGAHLRGRGRTV
YGAVRAVPPTAIPAYPGVVYQDGFYGADLYGGYAAYRYAQPATATAATAAAAAAAAYSDGYGRVYTADPYHALAPAASYGVGAVASLYRG

--------------------------------------------------------------

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr11:70118542/chr22:36164396)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePPFIA1chr11:70118541chr22:36164395ENST00000253925+22817_2588.01597.3333333333333Compositional biasNote=Poly-Gly
HgenePPFIA1chr11:70118541chr22:36164395ENST00000389547+22617_2588.01186.0Compositional biasNote=Poly-Gly
HgenePPFIA1chr11:70118542chr22:36161530ENST00000253925+22817_2588.01597.3333333333333Compositional biasNote=Poly-Gly
HgenePPFIA1chr11:70118542chr22:36161530ENST00000389547+22617_2588.01186.0Compositional biasNote=Poly-Gly
HgenePPFIA1chr11:70118542chr22:36164396ENST00000253925+22817_2588.01597.3333333333333Compositional biasNote=Poly-Gly
HgenePPFIA1chr11:70118542chr22:36164396ENST00000389547+22617_2588.01186.0Compositional biasNote=Poly-Gly
TgeneRBFOX2chr11:70118541chr22:36164395ENST00000262829212273_377132.0359.0Compositional biasNote=Ala-rich
TgeneRBFOX2chr11:70118541chr22:36164395ENST00000405409312273_377151.0368.0Compositional biasNote=Ala-rich
TgeneRBFOX2chr11:70118541chr22:36164395ENST00000414461312273_377150.0371.0Compositional biasNote=Ala-rich
TgeneRBFOX2chr11:70118541chr22:36164395ENST00000416721313273_377150.0377.0Compositional biasNote=Ala-rich
TgeneRBFOX2chr11:70118541chr22:36164395ENST00000438146414273_377221.0452.0Compositional biasNote=Ala-rich
TgeneRBFOX2chr11:70118541chr22:36164395ENST00000449924313273_377150.0381.0Compositional biasNote=Ala-rich
TgeneRBFOX2chr11:70118542chr22:36161530ENST00000262829312273_377163.0359.0Compositional biasNote=Ala-rich
TgeneRBFOX2chr11:70118542chr22:36161530ENST00000405409412273_377182.0368.0Compositional biasNote=Ala-rich
TgeneRBFOX2chr11:70118542chr22:36161530ENST00000414461412273_377181.0371.0Compositional biasNote=Ala-rich
TgeneRBFOX2chr11:70118542chr22:36161530ENST00000416721413273_377181.0377.0Compositional biasNote=Ala-rich
TgeneRBFOX2chr11:70118542chr22:36161530ENST00000438146514273_377252.0452.0Compositional biasNote=Ala-rich
TgeneRBFOX2chr11:70118542chr22:36161530ENST00000449924413273_377181.0381.0Compositional biasNote=Ala-rich
TgeneRBFOX2chr11:70118542chr22:36164396ENST00000262829212273_377132.0359.0Compositional biasNote=Ala-rich
TgeneRBFOX2chr11:70118542chr22:36164396ENST00000405409312273_377151.0368.0Compositional biasNote=Ala-rich
TgeneRBFOX2chr11:70118542chr22:36164396ENST00000414461312273_377150.0371.0Compositional biasNote=Ala-rich
TgeneRBFOX2chr11:70118542chr22:36164396ENST00000416721313273_377150.0377.0Compositional biasNote=Ala-rich
TgeneRBFOX2chr11:70118542chr22:36164396ENST00000438146414273_377221.0452.0Compositional biasNote=Ala-rich
TgeneRBFOX2chr11:70118542chr22:36164396ENST00000449924313273_377150.0381.0Compositional biasNote=Ala-rich

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePPFIA1chr11:70118541chr22:36164395ENST00000253925+2281021_105088.01597.3333333333333Coiled coilOntology_term=ECO:0000255
HgenePPFIA1chr11:70118541chr22:36164395ENST00000253925+228176_21488.01597.3333333333333Coiled coilOntology_term=ECO:0000255
HgenePPFIA1chr11:70118541chr22:36164395ENST00000253925+228249_52188.01597.3333333333333Coiled coilOntology_term=ECO:0000255
HgenePPFIA1chr11:70118541chr22:36164395ENST00000253925+22834_14188.01597.3333333333333Coiled coilOntology_term=ECO:0000255
HgenePPFIA1chr11:70118541chr22:36164395ENST00000253925+228623_66988.01597.3333333333333Coiled coilOntology_term=ECO:0000255
HgenePPFIA1chr11:70118541chr22:36164395ENST00000253925+228847_87188.01597.3333333333333Coiled coilOntology_term=ECO:0000255
HgenePPFIA1chr11:70118541chr22:36164395ENST00000389547+2261021_105088.01186.0Coiled coilOntology_term=ECO:0000255
HgenePPFIA1chr11:70118541chr22:36164395ENST00000389547+226176_21488.01186.0Coiled coilOntology_term=ECO:0000255
HgenePPFIA1chr11:70118541chr22:36164395ENST00000389547+226249_52188.01186.0Coiled coilOntology_term=ECO:0000255
HgenePPFIA1chr11:70118541chr22:36164395ENST00000389547+22634_14188.01186.0Coiled coilOntology_term=ECO:0000255
HgenePPFIA1chr11:70118541chr22:36164395ENST00000389547+226623_66988.01186.0Coiled coilOntology_term=ECO:0000255
HgenePPFIA1chr11:70118541chr22:36164395ENST00000389547+226847_87188.01186.0Coiled coilOntology_term=ECO:0000255
HgenePPFIA1chr11:70118542chr22:36161530ENST00000253925+2281021_105088.01597.3333333333333Coiled coilOntology_term=ECO:0000255
HgenePPFIA1chr11:70118542chr22:36161530ENST00000253925+228176_21488.01597.3333333333333Coiled coilOntology_term=ECO:0000255
HgenePPFIA1chr11:70118542chr22:36161530ENST00000253925+228249_52188.01597.3333333333333Coiled coilOntology_term=ECO:0000255
HgenePPFIA1chr11:70118542chr22:36161530ENST00000253925+22834_14188.01597.3333333333333Coiled coilOntology_term=ECO:0000255
HgenePPFIA1chr11:70118542chr22:36161530ENST00000253925+228623_66988.01597.3333333333333Coiled coilOntology_term=ECO:0000255
HgenePPFIA1chr11:70118542chr22:36161530ENST00000253925+228847_87188.01597.3333333333333Coiled coilOntology_term=ECO:0000255
HgenePPFIA1chr11:70118542chr22:36161530ENST00000389547+2261021_105088.01186.0Coiled coilOntology_term=ECO:0000255
HgenePPFIA1chr11:70118542chr22:36161530ENST00000389547+226176_21488.01186.0Coiled coilOntology_term=ECO:0000255
HgenePPFIA1chr11:70118542chr22:36161530ENST00000389547+226249_52188.01186.0Coiled coilOntology_term=ECO:0000255
HgenePPFIA1chr11:70118542chr22:36161530ENST00000389547+22634_14188.01186.0Coiled coilOntology_term=ECO:0000255
HgenePPFIA1chr11:70118542chr22:36161530ENST00000389547+226623_66988.01186.0Coiled coilOntology_term=ECO:0000255
HgenePPFIA1chr11:70118542chr22:36161530ENST00000389547+226847_87188.01186.0Coiled coilOntology_term=ECO:0000255
HgenePPFIA1chr11:70118542chr22:36164396ENST00000253925+2281021_105088.01597.3333333333333Coiled coilOntology_term=ECO:0000255
HgenePPFIA1chr11:70118542chr22:36164396ENST00000253925+228176_21488.01597.3333333333333Coiled coilOntology_term=ECO:0000255
HgenePPFIA1chr11:70118542chr22:36164396ENST00000253925+228249_52188.01597.3333333333333Coiled coilOntology_term=ECO:0000255
HgenePPFIA1chr11:70118542chr22:36164396ENST00000253925+22834_14188.01597.3333333333333Coiled coilOntology_term=ECO:0000255
HgenePPFIA1chr11:70118542chr22:36164396ENST00000253925+228623_66988.01597.3333333333333Coiled coilOntology_term=ECO:0000255
HgenePPFIA1chr11:70118542chr22:36164396ENST00000253925+228847_87188.01597.3333333333333Coiled coilOntology_term=ECO:0000255
HgenePPFIA1chr11:70118542chr22:36164396ENST00000389547+2261021_105088.01186.0Coiled coilOntology_term=ECO:0000255
HgenePPFIA1chr11:70118542chr22:36164396ENST00000389547+226176_21488.01186.0Coiled coilOntology_term=ECO:0000255
HgenePPFIA1chr11:70118542chr22:36164396ENST00000389547+226249_52188.01186.0Coiled coilOntology_term=ECO:0000255
HgenePPFIA1chr11:70118542chr22:36164396ENST00000389547+22634_14188.01186.0Coiled coilOntology_term=ECO:0000255
HgenePPFIA1chr11:70118542chr22:36164396ENST00000389547+226623_66988.01186.0Coiled coilOntology_term=ECO:0000255
HgenePPFIA1chr11:70118542chr22:36164396ENST00000389547+226847_87188.01186.0Coiled coilOntology_term=ECO:0000255
HgenePPFIA1chr11:70118541chr22:36164395ENST00000253925+2281051_112088.01597.3333333333333DomainSAM 3
HgenePPFIA1chr11:70118541chr22:36164395ENST00000253925+228878_94488.01597.3333333333333DomainSAM 1
HgenePPFIA1chr11:70118541chr22:36164395ENST00000253925+228963_102788.01597.3333333333333DomainSAM 2
HgenePPFIA1chr11:70118541chr22:36164395ENST00000389547+2261051_112088.01186.0DomainSAM 3
HgenePPFIA1chr11:70118541chr22:36164395ENST00000389547+226878_94488.01186.0DomainSAM 1
HgenePPFIA1chr11:70118541chr22:36164395ENST00000389547+226963_102788.01186.0DomainSAM 2
HgenePPFIA1chr11:70118542chr22:36161530ENST00000253925+2281051_112088.01597.3333333333333DomainSAM 3
HgenePPFIA1chr11:70118542chr22:36161530ENST00000253925+228878_94488.01597.3333333333333DomainSAM 1
HgenePPFIA1chr11:70118542chr22:36161530ENST00000253925+228963_102788.01597.3333333333333DomainSAM 2
HgenePPFIA1chr11:70118542chr22:36161530ENST00000389547+2261051_112088.01186.0DomainSAM 3
HgenePPFIA1chr11:70118542chr22:36161530ENST00000389547+226878_94488.01186.0DomainSAM 1
HgenePPFIA1chr11:70118542chr22:36161530ENST00000389547+226963_102788.01186.0DomainSAM 2
HgenePPFIA1chr11:70118542chr22:36164396ENST00000253925+2281051_112088.01597.3333333333333DomainSAM 3
HgenePPFIA1chr11:70118542chr22:36164396ENST00000253925+228878_94488.01597.3333333333333DomainSAM 1
HgenePPFIA1chr11:70118542chr22:36164396ENST00000253925+228963_102788.01597.3333333333333DomainSAM 2
HgenePPFIA1chr11:70118542chr22:36164396ENST00000389547+2261051_112088.01186.0DomainSAM 3
HgenePPFIA1chr11:70118542chr22:36164396ENST00000389547+226878_94488.01186.0DomainSAM 1
HgenePPFIA1chr11:70118542chr22:36164396ENST00000389547+226963_102788.01186.0DomainSAM 2
TgeneRBFOX2chr11:70118541chr22:36164395ENST00000262829212121_197132.0359.0DomainRRM
TgeneRBFOX2chr11:70118541chr22:36164395ENST00000405409312121_197151.0368.0DomainRRM
TgeneRBFOX2chr11:70118541chr22:36164395ENST00000414461312121_197150.0371.0DomainRRM
TgeneRBFOX2chr11:70118541chr22:36164395ENST00000416721313121_197150.0377.0DomainRRM
TgeneRBFOX2chr11:70118541chr22:36164395ENST00000438146414121_197221.0452.0DomainRRM
TgeneRBFOX2chr11:70118541chr22:36164395ENST00000449924313121_197150.0381.0DomainRRM
TgeneRBFOX2chr11:70118542chr22:36161530ENST00000262829312121_197163.0359.0DomainRRM
TgeneRBFOX2chr11:70118542chr22:36161530ENST00000405409412121_197182.0368.0DomainRRM
TgeneRBFOX2chr11:70118542chr22:36161530ENST00000414461412121_197181.0371.0DomainRRM
TgeneRBFOX2chr11:70118542chr22:36161530ENST00000416721413121_197181.0377.0DomainRRM
TgeneRBFOX2chr11:70118542chr22:36161530ENST00000438146514121_197252.0452.0DomainRRM
TgeneRBFOX2chr11:70118542chr22:36161530ENST00000449924413121_197181.0381.0DomainRRM
TgeneRBFOX2chr11:70118542chr22:36164396ENST00000262829212121_197132.0359.0DomainRRM
TgeneRBFOX2chr11:70118542chr22:36164396ENST00000405409312121_197151.0368.0DomainRRM
TgeneRBFOX2chr11:70118542chr22:36164396ENST00000414461312121_197150.0371.0DomainRRM
TgeneRBFOX2chr11:70118542chr22:36164396ENST00000416721313121_197150.0377.0DomainRRM
TgeneRBFOX2chr11:70118542chr22:36164396ENST00000438146414121_197221.0452.0DomainRRM
TgeneRBFOX2chr11:70118542chr22:36164396ENST00000449924313121_197150.0381.0DomainRRM


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Fusion Protein Structures

check button PDB and CIF files of the predicted fusion proteins
* Here we show the 3D structure of the fusion proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format.
Fusion protein PDB link (fusion AA seq ID in FusionPDB)HgeneHchrHbpHstrandTgeneTchrTbpTstrandAA seqLen(AA seq)
PDB file >>>750_PPFIA1_70118542_RBFOX2_36164396_ranked_0.pdbPPFIA17011854170118542ENST00000438146RBFOX2chr2236164396-
MGRRAPGPRRGAGRRTPAAGCFRRLPSSPGASSRPRAAAEPPRPLPPASKMMCEVMPTISEAEGPPGGGGGHGSGSPSQPDADSHFEQLM
VSMLEERDRLLDTLRETQETLALTQGKLHEVGHERDSLQRQLNTALPQGFGFVTFENSADADRAREKLHGTVVEGRKIEVNNATARVMTN
KKMVTPYANGWKLSPVVGAVYGPELYAASSFQADVSLGNDAAVPLSGRGGINTYIPLIIPGFPYPTAATTAAAFRGAHLRGRGRTVYGAV
RAVPPTAIPAYPGVVYQDGFYGADLYIESANCFRSNRVDMQPTDMHSLLLQPQPPLLQPLQPLTVTVMAGCTQPTPTMPLPLPLAMELAL
378


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pLDDT score distribution

check button pLDDT score distribution of the predicted wild-type structures of two partner proteins from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.
PPFIA1_pLDDT.png
all structure
all structure
RBFOX2_pLDDT.png
all structure
all structure

check button pLDDT score distribution of the predicted fusion protein structures from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.
all structure


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Ramachandran Plot of Fusion Protein Structure


check button Ramachandran plot of the torsional angles - phi (φ)and psi (ψ) - of the residues (amino acids) contained in this fusion protein peptide.
Fusion AA seq ID in FusionPDB and their Ramachandran plots

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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
PPFIA1
RBFOX2


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to PPFIA1-RBFOX2


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to PPFIA1-RBFOX2


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource