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Center for Computational Systems Medicine level1
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:PPFIA2-HMGA2

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: PPFIA2-HMGA2
FusionPDB ID: 67431
FusionGDB2.0 ID: 67431
HgeneTgene
Gene symbol

PPFIA2

HMGA2

Gene ID

8499

8091

Gene namePTPRF interacting protein alpha 2high mobility group AT-hook 2
Synonyms-BABL|HMGI-C|HMGIC|LIPO|STQTL9
Cytomap

12q21.31

12q14.3

Type of geneprotein-codingprotein-coding
Descriptionliprin-alpha-2protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 2high mobility group protein HMGI-CHMGA2/KRT121P fusionhigh-mobility group (nonhistone chromosomal) protein isoform I-C
Modification date2020031320200329
UniProtAcc.

P52926

Ensembl transtripts involved in fusion geneENST idsENST00000333447, ENST00000548586, 
ENST00000549325, ENST00000549396, 
ENST00000550584, ENST00000552948, 
ENST00000407050, ENST00000443686, 
ENST00000541017, ENST00000541570, 
ENST00000545296, ENST00000550359, 
ENST00000354636, ENST00000393577, 
ENST00000393578, ENST00000403681, 
ENST00000425208, ENST00000536545, 
ENST00000541363, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score17 X 14 X 4=95216 X 12 X 5=960
# samples 1815
** MAII scorelog2(18/952*10)=-2.40296466697827
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(15/960*10)=-2.67807190511264
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: PPFIA2 [Title/Abstract] AND HMGA2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)PPFIA2(82147751)-HMGA2(66221780), # samples:1
HMGA2(66232349)-PPFIA2(81851645), # samples:1
Anticipated loss of major functional domain due to fusion event.PPFIA2-HMGA2 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
PPFIA2-HMGA2 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
PPFIA2-HMGA2 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
PPFIA2-HMGA2 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneHMGA2

GO:0000122

negative regulation of transcription by RNA polymerase II

14627817

TgeneHMGA2

GO:0002062

chondrocyte differentiation

21484705

TgeneHMGA2

GO:0006284

base-excision repair

19465398

TgeneHMGA2

GO:0007095

mitotic G2 DNA damage checkpoint

16061642

TgeneHMGA2

GO:0010564

regulation of cell cycle process

14645522

TgeneHMGA2

GO:0010628

positive regulation of gene expression

18832382

TgeneHMGA2

GO:0031052

chromosome breakage

19549901

TgeneHMGA2

GO:0031507

heterochromatin assembly

16901784

TgeneHMGA2

GO:0035978

histone H2A-S139 phosphorylation

16061642

TgeneHMGA2

GO:0035986

senescence-associated heterochromatin focus assembly

16901784

TgeneHMGA2

GO:0035988

chondrocyte proliferation

21484705

TgeneHMGA2

GO:0042769

DNA damage response, detection of DNA damage

19465398

TgeneHMGA2

GO:0043065

positive regulation of apoptotic process

16061642

TgeneHMGA2

GO:0043066

negative regulation of apoptotic process

19465398

TgeneHMGA2

GO:0043392

negative regulation of DNA binding

14645522

TgeneHMGA2

GO:0043922

negative regulation by host of viral transcription

17005673

TgeneHMGA2

GO:0045869

negative regulation of single stranded viral RNA replication via double stranded DNA intermediate

17005673

TgeneHMGA2

GO:0045892

negative regulation of transcription, DNA-templated

18832382

TgeneHMGA2

GO:0045893

positive regulation of transcription, DNA-templated

15225648|15755872|17005673|17324944|17426251

TgeneHMGA2

GO:0045944

positive regulation of transcription by RNA polymerase II

14645522|18832382

TgeneHMGA2

GO:0071158

positive regulation of cell cycle arrest

16061642

TgeneHMGA2

GO:0071902

positive regulation of protein serine/threonine kinase activity

19549901

TgeneHMGA2

GO:0090402

oncogene-induced cell senescence

16901784

TgeneHMGA2

GO:2000648

positive regulation of stem cell proliferation

21484705

TgeneHMGA2

GO:2000679

positive regulation of transcription regulatory region DNA binding

18832382

TgeneHMGA2

GO:2000685

positive regulation of cellular response to X-ray

16061642

TgeneHMGA2

GO:2001022

positive regulation of response to DNA damage stimulus

16061642|19465398

TgeneHMGA2

GO:2001033

negative regulation of double-strand break repair via nonhomologous end joining

19549901

TgeneHMGA2

GO:2001038

regulation of cellular response to drug

16061642


check buttonFusion gene breakpoints across PPFIA2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across HMGA2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4SARCTCGA-FX-A2QSPPFIA2chr12

82147751

-HMGA2chr12

66221780

+


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000549396PPFIA2chr1282147751-ENST00000403681HMGA2chr1266221780+3632410161628155
ENST00000549396PPFIA2chr1282147751-ENST00000541363HMGA2chr1266221780+8020410161598145
ENST00000549396PPFIA2chr1282147751-ENST00000393577HMGA2chr1266221780+762410161655164
ENST00000549396PPFIA2chr1282147751-ENST00000393578HMGA2chr1266221780+886410161571136
ENST00000549396PPFIA2chr1282147751-ENST00000425208HMGA2chr1266221780+932410161577138
ENST00000549396PPFIA2chr1282147751-ENST00000536545HMGA2chr1266221780+1276410161742193
ENST00000549396PPFIA2chr1282147751-ENST00000354636HMGA2chr1266221780+1017410161619152
ENST00000550584PPFIA2chr1282147751-ENST00000403681HMGA2chr1266221780+3767545296763155
ENST00000550584PPFIA2chr1282147751-ENST00000541363HMGA2chr1266221780+8155545296733145
ENST00000550584PPFIA2chr1282147751-ENST00000393577HMGA2chr1266221780+897545296790164
ENST00000550584PPFIA2chr1282147751-ENST00000393578HMGA2chr1266221780+1021545296706136
ENST00000550584PPFIA2chr1282147751-ENST00000425208HMGA2chr1266221780+1067545296712138
ENST00000550584PPFIA2chr1282147751-ENST00000536545HMGA2chr1266221780+1411545296877193
ENST00000550584PPFIA2chr1282147751-ENST00000354636HMGA2chr1266221780+1152545296754152
ENST00000549325PPFIA2chr1282147751-ENST00000403681HMGA2chr1266221780+3744522273740155
ENST00000549325PPFIA2chr1282147751-ENST00000541363HMGA2chr1266221780+8132522273710145
ENST00000549325PPFIA2chr1282147751-ENST00000393577HMGA2chr1266221780+874522273767164
ENST00000549325PPFIA2chr1282147751-ENST00000393578HMGA2chr1266221780+998522273683136
ENST00000549325PPFIA2chr1282147751-ENST00000425208HMGA2chr1266221780+1044522273689138
ENST00000549325PPFIA2chr1282147751-ENST00000536545HMGA2chr1266221780+1388522273854193
ENST00000549325PPFIA2chr1282147751-ENST00000354636HMGA2chr1266221780+1129522273731152
ENST00000333447PPFIA2chr1282147751-ENST00000403681HMGA2chr1266221780+34712490467155
ENST00000333447PPFIA2chr1282147751-ENST00000541363HMGA2chr1266221780+78592490437145
ENST00000333447PPFIA2chr1282147751-ENST00000393577HMGA2chr1266221780+6012490494164
ENST00000333447PPFIA2chr1282147751-ENST00000393578HMGA2chr1266221780+7252490410136
ENST00000333447PPFIA2chr1282147751-ENST00000425208HMGA2chr1266221780+7712490416138
ENST00000333447PPFIA2chr1282147751-ENST00000536545HMGA2chr1266221780+11152490581193
ENST00000333447PPFIA2chr1282147751-ENST00000354636HMGA2chr1266221780+8562490458152
ENST00000548586PPFIA2chr1282147751-ENST00000403681HMGA2chr1266221780+3727505256723155
ENST00000548586PPFIA2chr1282147751-ENST00000541363HMGA2chr1266221780+8115505256693145
ENST00000548586PPFIA2chr1282147751-ENST00000393577HMGA2chr1266221780+857505256750164
ENST00000548586PPFIA2chr1282147751-ENST00000393578HMGA2chr1266221780+981505256666136
ENST00000548586PPFIA2chr1282147751-ENST00000425208HMGA2chr1266221780+1027505256672138
ENST00000548586PPFIA2chr1282147751-ENST00000536545HMGA2chr1266221780+1371505256837193
ENST00000548586PPFIA2chr1282147751-ENST00000354636HMGA2chr1266221780+1112505256714152
ENST00000552948PPFIA2chr1282147751-ENST00000403681HMGA2chr1266221780+3721499250717155
ENST00000552948PPFIA2chr1282147751-ENST00000541363HMGA2chr1266221780+8109499250687145
ENST00000552948PPFIA2chr1282147751-ENST00000393577HMGA2chr1266221780+851499250744164
ENST00000552948PPFIA2chr1282147751-ENST00000393578HMGA2chr1266221780+975499250660136
ENST00000552948PPFIA2chr1282147751-ENST00000425208HMGA2chr1266221780+1021499250666138
ENST00000552948PPFIA2chr1282147751-ENST00000536545HMGA2chr1266221780+1365499250831193
ENST00000552948PPFIA2chr1282147751-ENST00000354636HMGA2chr1266221780+1106499250708152

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000549396ENST00000403681PPFIA2chr1282147751-HMGA2chr1266221780+0.0020905090.9979095
ENST00000549396ENST00000541363PPFIA2chr1282147751-HMGA2chr1266221780+0.0051953220.9948047
ENST00000549396ENST00000393577PPFIA2chr1282147751-HMGA2chr1266221780+0.0120830580.9879169
ENST00000549396ENST00000393578PPFIA2chr1282147751-HMGA2chr1266221780+0.011945150.9880548
ENST00000549396ENST00000425208PPFIA2chr1282147751-HMGA2chr1266221780+0.0380599650.96194005
ENST00000549396ENST00000536545PPFIA2chr1282147751-HMGA2chr1266221780+0.1023206040.8976793
ENST00000549396ENST00000354636PPFIA2chr1282147751-HMGA2chr1266221780+0.0267983660.97320163
ENST00000550584ENST00000403681PPFIA2chr1282147751-HMGA2chr1266221780+0.0019795090.9980205
ENST00000550584ENST00000541363PPFIA2chr1282147751-HMGA2chr1266221780+0.0050174970.9949825
ENST00000550584ENST00000393577PPFIA2chr1282147751-HMGA2chr1266221780+0.008398550.9916014
ENST00000550584ENST00000393578PPFIA2chr1282147751-HMGA2chr1266221780+0.0188111760.98118883
ENST00000550584ENST00000425208PPFIA2chr1282147751-HMGA2chr1266221780+0.0592924060.9407076
ENST00000550584ENST00000536545PPFIA2chr1282147751-HMGA2chr1266221780+0.108539480.89146054
ENST00000550584ENST00000354636PPFIA2chr1282147751-HMGA2chr1266221780+0.0269261450.97307384
ENST00000549325ENST00000403681PPFIA2chr1282147751-HMGA2chr1266221780+0.0019250130.998075
ENST00000549325ENST00000541363PPFIA2chr1282147751-HMGA2chr1266221780+0.0049197580.99508023
ENST00000549325ENST00000393577PPFIA2chr1282147751-HMGA2chr1266221780+0.0053447080.99465525
ENST00000549325ENST00000393578PPFIA2chr1282147751-HMGA2chr1266221780+0.0116314370.9883686
ENST00000549325ENST00000425208PPFIA2chr1282147751-HMGA2chr1266221780+0.0316912230.96830875
ENST00000549325ENST00000536545PPFIA2chr1282147751-HMGA2chr1266221780+0.068398960.93160105
ENST00000549325ENST00000354636PPFIA2chr1282147751-HMGA2chr1266221780+0.01611380.98388624
ENST00000333447ENST00000403681PPFIA2chr1282147751-HMGA2chr1266221780+0.0020188520.99798113
ENST00000333447ENST00000541363PPFIA2chr1282147751-HMGA2chr1266221780+0.0050903460.9949097
ENST00000333447ENST00000393577PPFIA2chr1282147751-HMGA2chr1266221780+0.0155715440.9844284
ENST00000333447ENST00000393578PPFIA2chr1282147751-HMGA2chr1266221780+0.0183844960.9816155
ENST00000333447ENST00000425208PPFIA2chr1282147751-HMGA2chr1266221780+0.051696030.948304
ENST00000333447ENST00000536545PPFIA2chr1282147751-HMGA2chr1266221780+0.132959380.86704063
ENST00000333447ENST00000354636PPFIA2chr1282147751-HMGA2chr1266221780+0.0356668760.9643332
ENST00000548586ENST00000403681PPFIA2chr1282147751-HMGA2chr1266221780+0.0019246690.99807537
ENST00000548586ENST00000541363PPFIA2chr1282147751-HMGA2chr1266221780+0.0049350550.9950649
ENST00000548586ENST00000393577PPFIA2chr1282147751-HMGA2chr1266221780+0.0092816970.9907183
ENST00000548586ENST00000393578PPFIA2chr1282147751-HMGA2chr1266221780+0.0193173380.9806826
ENST00000548586ENST00000425208PPFIA2chr1282147751-HMGA2chr1266221780+0.0557862860.9442137
ENST00000548586ENST00000536545PPFIA2chr1282147751-HMGA2chr1266221780+0.08767890.9123211
ENST00000548586ENST00000354636PPFIA2chr1282147751-HMGA2chr1266221780+0.027150310.9728497
ENST00000552948ENST00000403681PPFIA2chr1282147751-HMGA2chr1266221780+0.0019639930.99803597
ENST00000552948ENST00000541363PPFIA2chr1282147751-HMGA2chr1266221780+0.0049711790.9950288
ENST00000552948ENST00000393577PPFIA2chr1282147751-HMGA2chr1266221780+0.0073940350.9926059
ENST00000552948ENST00000393578PPFIA2chr1282147751-HMGA2chr1266221780+0.016923940.9830761
ENST00000552948ENST00000425208PPFIA2chr1282147751-HMGA2chr1266221780+0.037718380.9622816
ENST00000552948ENST00000536545PPFIA2chr1282147751-HMGA2chr1266221780+0.086463860.9135362
ENST00000552948ENST00000354636PPFIA2chr1282147751-HMGA2chr1266221780+0.020055560.97994447

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>67431_67431_1_PPFIA2-HMGA2_PPFIA2_chr12_82147751_ENST00000333447_HMGA2_chr12_66221780_ENST00000354636_length(amino acids)=152AA_BP=83
MMCEVMPTINEDTPMSQRGSQSSGSDSDSHFEQLMVNMLDERDRLLDTLRETQESLSLAQQRLQDVIYDRDSLQRQLNSALPQEPTGEPS

--------------------------------------------------------------

>67431_67431_2_PPFIA2-HMGA2_PPFIA2_chr12_82147751_ENST00000333447_HMGA2_chr12_66221780_ENST00000393577_length(amino acids)=164AA_BP=83
MMCEVMPTINEDTPMSQRGSQSSGSDSDSHFEQLMVNMLDERDRLLDTLRETQESLSLAQQRLQDVIYDRDSLQRQLNSALPQEPTGEPS

--------------------------------------------------------------

>67431_67431_3_PPFIA2-HMGA2_PPFIA2_chr12_82147751_ENST00000333447_HMGA2_chr12_66221780_ENST00000393578_length(amino acids)=136AA_BP=83
MMCEVMPTINEDTPMSQRGSQSSGSDSDSHFEQLMVNMLDERDRLLDTLRETQESLSLAQQRLQDVIYDRDSLQRQLNSALPQEPTGEPS

--------------------------------------------------------------

>67431_67431_4_PPFIA2-HMGA2_PPFIA2_chr12_82147751_ENST00000333447_HMGA2_chr12_66221780_ENST00000403681_length(amino acids)=155AA_BP=83
MMCEVMPTINEDTPMSQRGSQSSGSDSDSHFEQLMVNMLDERDRLLDTLRETQESLSLAQQRLQDVIYDRDSLQRQLNSALPQEPTGEPS

--------------------------------------------------------------

>67431_67431_5_PPFIA2-HMGA2_PPFIA2_chr12_82147751_ENST00000333447_HMGA2_chr12_66221780_ENST00000425208_length(amino acids)=138AA_BP=83
MMCEVMPTINEDTPMSQRGSQSSGSDSDSHFEQLMVNMLDERDRLLDTLRETQESLSLAQQRLQDVIYDRDSLQRQLNSALPQEPTGEPS

--------------------------------------------------------------

>67431_67431_6_PPFIA2-HMGA2_PPFIA2_chr12_82147751_ENST00000333447_HMGA2_chr12_66221780_ENST00000536545_length(amino acids)=193AA_BP=83
MMCEVMPTINEDTPMSQRGSQSSGSDSDSHFEQLMVNMLDERDRLLDTLRETQESLSLAQQRLQDVIYDRDSLQRQLNSALPQEPTGEPS
PKRPRGRPKGSKNKSPSKAAQKKAEATGEKRPRGRPRKWAGVQWYNLGSLQPPPPRFKQFSCLRLLSSWDYRHPPPHPANFCIFSRDRVS

--------------------------------------------------------------

>67431_67431_7_PPFIA2-HMGA2_PPFIA2_chr12_82147751_ENST00000333447_HMGA2_chr12_66221780_ENST00000541363_length(amino acids)=145AA_BP=83
MMCEVMPTINEDTPMSQRGSQSSGSDSDSHFEQLMVNMLDERDRLLDTLRETQESLSLAQQRLQDVIYDRDSLQRQLNSALPQEPTGEPS

--------------------------------------------------------------

>67431_67431_8_PPFIA2-HMGA2_PPFIA2_chr12_82147751_ENST00000548586_HMGA2_chr12_66221780_ENST00000354636_length(amino acids)=152AA_BP=83
MMCEVMPTINEDTPMSQRGSQSSGSDSDSHFEQLMVNMLDERDRLLDTLRETQESLSLAQQRLQDVIYDRDSLQRQLNSALPQEPTGEPS

--------------------------------------------------------------

>67431_67431_9_PPFIA2-HMGA2_PPFIA2_chr12_82147751_ENST00000548586_HMGA2_chr12_66221780_ENST00000393577_length(amino acids)=164AA_BP=83
MMCEVMPTINEDTPMSQRGSQSSGSDSDSHFEQLMVNMLDERDRLLDTLRETQESLSLAQQRLQDVIYDRDSLQRQLNSALPQEPTGEPS

--------------------------------------------------------------

>67431_67431_10_PPFIA2-HMGA2_PPFIA2_chr12_82147751_ENST00000548586_HMGA2_chr12_66221780_ENST00000393578_length(amino acids)=136AA_BP=83
MMCEVMPTINEDTPMSQRGSQSSGSDSDSHFEQLMVNMLDERDRLLDTLRETQESLSLAQQRLQDVIYDRDSLQRQLNSALPQEPTGEPS

--------------------------------------------------------------

>67431_67431_11_PPFIA2-HMGA2_PPFIA2_chr12_82147751_ENST00000548586_HMGA2_chr12_66221780_ENST00000403681_length(amino acids)=155AA_BP=83
MMCEVMPTINEDTPMSQRGSQSSGSDSDSHFEQLMVNMLDERDRLLDTLRETQESLSLAQQRLQDVIYDRDSLQRQLNSALPQEPTGEPS

--------------------------------------------------------------

>67431_67431_12_PPFIA2-HMGA2_PPFIA2_chr12_82147751_ENST00000548586_HMGA2_chr12_66221780_ENST00000425208_length(amino acids)=138AA_BP=83
MMCEVMPTINEDTPMSQRGSQSSGSDSDSHFEQLMVNMLDERDRLLDTLRETQESLSLAQQRLQDVIYDRDSLQRQLNSALPQEPTGEPS

--------------------------------------------------------------

>67431_67431_13_PPFIA2-HMGA2_PPFIA2_chr12_82147751_ENST00000548586_HMGA2_chr12_66221780_ENST00000536545_length(amino acids)=193AA_BP=83
MMCEVMPTINEDTPMSQRGSQSSGSDSDSHFEQLMVNMLDERDRLLDTLRETQESLSLAQQRLQDVIYDRDSLQRQLNSALPQEPTGEPS
PKRPRGRPKGSKNKSPSKAAQKKAEATGEKRPRGRPRKWAGVQWYNLGSLQPPPPRFKQFSCLRLLSSWDYRHPPPHPANFCIFSRDRVS

--------------------------------------------------------------

>67431_67431_14_PPFIA2-HMGA2_PPFIA2_chr12_82147751_ENST00000548586_HMGA2_chr12_66221780_ENST00000541363_length(amino acids)=145AA_BP=83
MMCEVMPTINEDTPMSQRGSQSSGSDSDSHFEQLMVNMLDERDRLLDTLRETQESLSLAQQRLQDVIYDRDSLQRQLNSALPQEPTGEPS

--------------------------------------------------------------

>67431_67431_15_PPFIA2-HMGA2_PPFIA2_chr12_82147751_ENST00000549325_HMGA2_chr12_66221780_ENST00000354636_length(amino acids)=152AA_BP=83
MMCEVMPTINEDTPMSQRGSQSSGSDSDSHFEQLMVNMLDERDRLLDTLRETQESLSLAQQRLQDVIYDRDSLQRQLNSALPQEPTGEPS

--------------------------------------------------------------

>67431_67431_16_PPFIA2-HMGA2_PPFIA2_chr12_82147751_ENST00000549325_HMGA2_chr12_66221780_ENST00000393577_length(amino acids)=164AA_BP=83
MMCEVMPTINEDTPMSQRGSQSSGSDSDSHFEQLMVNMLDERDRLLDTLRETQESLSLAQQRLQDVIYDRDSLQRQLNSALPQEPTGEPS

--------------------------------------------------------------

>67431_67431_17_PPFIA2-HMGA2_PPFIA2_chr12_82147751_ENST00000549325_HMGA2_chr12_66221780_ENST00000393578_length(amino acids)=136AA_BP=83
MMCEVMPTINEDTPMSQRGSQSSGSDSDSHFEQLMVNMLDERDRLLDTLRETQESLSLAQQRLQDVIYDRDSLQRQLNSALPQEPTGEPS

--------------------------------------------------------------

>67431_67431_18_PPFIA2-HMGA2_PPFIA2_chr12_82147751_ENST00000549325_HMGA2_chr12_66221780_ENST00000403681_length(amino acids)=155AA_BP=83
MMCEVMPTINEDTPMSQRGSQSSGSDSDSHFEQLMVNMLDERDRLLDTLRETQESLSLAQQRLQDVIYDRDSLQRQLNSALPQEPTGEPS

--------------------------------------------------------------

>67431_67431_19_PPFIA2-HMGA2_PPFIA2_chr12_82147751_ENST00000549325_HMGA2_chr12_66221780_ENST00000425208_length(amino acids)=138AA_BP=83
MMCEVMPTINEDTPMSQRGSQSSGSDSDSHFEQLMVNMLDERDRLLDTLRETQESLSLAQQRLQDVIYDRDSLQRQLNSALPQEPTGEPS

--------------------------------------------------------------

>67431_67431_20_PPFIA2-HMGA2_PPFIA2_chr12_82147751_ENST00000549325_HMGA2_chr12_66221780_ENST00000536545_length(amino acids)=193AA_BP=83
MMCEVMPTINEDTPMSQRGSQSSGSDSDSHFEQLMVNMLDERDRLLDTLRETQESLSLAQQRLQDVIYDRDSLQRQLNSALPQEPTGEPS
PKRPRGRPKGSKNKSPSKAAQKKAEATGEKRPRGRPRKWAGVQWYNLGSLQPPPPRFKQFSCLRLLSSWDYRHPPPHPANFCIFSRDRVS

--------------------------------------------------------------

>67431_67431_21_PPFIA2-HMGA2_PPFIA2_chr12_82147751_ENST00000549325_HMGA2_chr12_66221780_ENST00000541363_length(amino acids)=145AA_BP=83
MMCEVMPTINEDTPMSQRGSQSSGSDSDSHFEQLMVNMLDERDRLLDTLRETQESLSLAQQRLQDVIYDRDSLQRQLNSALPQEPTGEPS

--------------------------------------------------------------

>67431_67431_22_PPFIA2-HMGA2_PPFIA2_chr12_82147751_ENST00000549396_HMGA2_chr12_66221780_ENST00000354636_length(amino acids)=152AA_BP=83
MMCEVMPTINEDTPMSQRGSQSSGSDSDSHFEQLMVNMLDERDRLLDTLRETQESLSLAQQRLQDVIYDRDSLQRQLNSALPQEPTGEPS

--------------------------------------------------------------

>67431_67431_23_PPFIA2-HMGA2_PPFIA2_chr12_82147751_ENST00000549396_HMGA2_chr12_66221780_ENST00000393577_length(amino acids)=164AA_BP=83
MMCEVMPTINEDTPMSQRGSQSSGSDSDSHFEQLMVNMLDERDRLLDTLRETQESLSLAQQRLQDVIYDRDSLQRQLNSALPQEPTGEPS

--------------------------------------------------------------

>67431_67431_24_PPFIA2-HMGA2_PPFIA2_chr12_82147751_ENST00000549396_HMGA2_chr12_66221780_ENST00000393578_length(amino acids)=136AA_BP=83
MMCEVMPTINEDTPMSQRGSQSSGSDSDSHFEQLMVNMLDERDRLLDTLRETQESLSLAQQRLQDVIYDRDSLQRQLNSALPQEPTGEPS

--------------------------------------------------------------

>67431_67431_25_PPFIA2-HMGA2_PPFIA2_chr12_82147751_ENST00000549396_HMGA2_chr12_66221780_ENST00000403681_length(amino acids)=155AA_BP=83
MMCEVMPTINEDTPMSQRGSQSSGSDSDSHFEQLMVNMLDERDRLLDTLRETQESLSLAQQRLQDVIYDRDSLQRQLNSALPQEPTGEPS

--------------------------------------------------------------

>67431_67431_26_PPFIA2-HMGA2_PPFIA2_chr12_82147751_ENST00000549396_HMGA2_chr12_66221780_ENST00000425208_length(amino acids)=138AA_BP=83
MMCEVMPTINEDTPMSQRGSQSSGSDSDSHFEQLMVNMLDERDRLLDTLRETQESLSLAQQRLQDVIYDRDSLQRQLNSALPQEPTGEPS

--------------------------------------------------------------

>67431_67431_27_PPFIA2-HMGA2_PPFIA2_chr12_82147751_ENST00000549396_HMGA2_chr12_66221780_ENST00000536545_length(amino acids)=193AA_BP=83
MMCEVMPTINEDTPMSQRGSQSSGSDSDSHFEQLMVNMLDERDRLLDTLRETQESLSLAQQRLQDVIYDRDSLQRQLNSALPQEPTGEPS
PKRPRGRPKGSKNKSPSKAAQKKAEATGEKRPRGRPRKWAGVQWYNLGSLQPPPPRFKQFSCLRLLSSWDYRHPPPHPANFCIFSRDRVS

--------------------------------------------------------------

>67431_67431_28_PPFIA2-HMGA2_PPFIA2_chr12_82147751_ENST00000549396_HMGA2_chr12_66221780_ENST00000541363_length(amino acids)=145AA_BP=83
MMCEVMPTINEDTPMSQRGSQSSGSDSDSHFEQLMVNMLDERDRLLDTLRETQESLSLAQQRLQDVIYDRDSLQRQLNSALPQEPTGEPS

--------------------------------------------------------------

>67431_67431_29_PPFIA2-HMGA2_PPFIA2_chr12_82147751_ENST00000550584_HMGA2_chr12_66221780_ENST00000354636_length(amino acids)=152AA_BP=83
MMCEVMPTINEDTPMSQRGSQSSGSDSDSHFEQLMVNMLDERDRLLDTLRETQESLSLAQQRLQDVIYDRDSLQRQLNSALPQEPTGEPS

--------------------------------------------------------------

>67431_67431_30_PPFIA2-HMGA2_PPFIA2_chr12_82147751_ENST00000550584_HMGA2_chr12_66221780_ENST00000393577_length(amino acids)=164AA_BP=83
MMCEVMPTINEDTPMSQRGSQSSGSDSDSHFEQLMVNMLDERDRLLDTLRETQESLSLAQQRLQDVIYDRDSLQRQLNSALPQEPTGEPS

--------------------------------------------------------------

>67431_67431_31_PPFIA2-HMGA2_PPFIA2_chr12_82147751_ENST00000550584_HMGA2_chr12_66221780_ENST00000393578_length(amino acids)=136AA_BP=83
MMCEVMPTINEDTPMSQRGSQSSGSDSDSHFEQLMVNMLDERDRLLDTLRETQESLSLAQQRLQDVIYDRDSLQRQLNSALPQEPTGEPS

--------------------------------------------------------------

>67431_67431_32_PPFIA2-HMGA2_PPFIA2_chr12_82147751_ENST00000550584_HMGA2_chr12_66221780_ENST00000403681_length(amino acids)=155AA_BP=83
MMCEVMPTINEDTPMSQRGSQSSGSDSDSHFEQLMVNMLDERDRLLDTLRETQESLSLAQQRLQDVIYDRDSLQRQLNSALPQEPTGEPS

--------------------------------------------------------------

>67431_67431_33_PPFIA2-HMGA2_PPFIA2_chr12_82147751_ENST00000550584_HMGA2_chr12_66221780_ENST00000425208_length(amino acids)=138AA_BP=83
MMCEVMPTINEDTPMSQRGSQSSGSDSDSHFEQLMVNMLDERDRLLDTLRETQESLSLAQQRLQDVIYDRDSLQRQLNSALPQEPTGEPS

--------------------------------------------------------------

>67431_67431_34_PPFIA2-HMGA2_PPFIA2_chr12_82147751_ENST00000550584_HMGA2_chr12_66221780_ENST00000536545_length(amino acids)=193AA_BP=83
MMCEVMPTINEDTPMSQRGSQSSGSDSDSHFEQLMVNMLDERDRLLDTLRETQESLSLAQQRLQDVIYDRDSLQRQLNSALPQEPTGEPS
PKRPRGRPKGSKNKSPSKAAQKKAEATGEKRPRGRPRKWAGVQWYNLGSLQPPPPRFKQFSCLRLLSSWDYRHPPPHPANFCIFSRDRVS

--------------------------------------------------------------

>67431_67431_35_PPFIA2-HMGA2_PPFIA2_chr12_82147751_ENST00000550584_HMGA2_chr12_66221780_ENST00000541363_length(amino acids)=145AA_BP=83
MMCEVMPTINEDTPMSQRGSQSSGSDSDSHFEQLMVNMLDERDRLLDTLRETQESLSLAQQRLQDVIYDRDSLQRQLNSALPQEPTGEPS

--------------------------------------------------------------

>67431_67431_36_PPFIA2-HMGA2_PPFIA2_chr12_82147751_ENST00000552948_HMGA2_chr12_66221780_ENST00000354636_length(amino acids)=152AA_BP=83
MMCEVMPTINEDTPMSQRGSQSSGSDSDSHFEQLMVNMLDERDRLLDTLRETQESLSLAQQRLQDVIYDRDSLQRQLNSALPQEPTGEPS

--------------------------------------------------------------

>67431_67431_37_PPFIA2-HMGA2_PPFIA2_chr12_82147751_ENST00000552948_HMGA2_chr12_66221780_ENST00000393577_length(amino acids)=164AA_BP=83
MMCEVMPTINEDTPMSQRGSQSSGSDSDSHFEQLMVNMLDERDRLLDTLRETQESLSLAQQRLQDVIYDRDSLQRQLNSALPQEPTGEPS

--------------------------------------------------------------

>67431_67431_38_PPFIA2-HMGA2_PPFIA2_chr12_82147751_ENST00000552948_HMGA2_chr12_66221780_ENST00000393578_length(amino acids)=136AA_BP=83
MMCEVMPTINEDTPMSQRGSQSSGSDSDSHFEQLMVNMLDERDRLLDTLRETQESLSLAQQRLQDVIYDRDSLQRQLNSALPQEPTGEPS

--------------------------------------------------------------

>67431_67431_39_PPFIA2-HMGA2_PPFIA2_chr12_82147751_ENST00000552948_HMGA2_chr12_66221780_ENST00000403681_length(amino acids)=155AA_BP=83
MMCEVMPTINEDTPMSQRGSQSSGSDSDSHFEQLMVNMLDERDRLLDTLRETQESLSLAQQRLQDVIYDRDSLQRQLNSALPQEPTGEPS

--------------------------------------------------------------

>67431_67431_40_PPFIA2-HMGA2_PPFIA2_chr12_82147751_ENST00000552948_HMGA2_chr12_66221780_ENST00000425208_length(amino acids)=138AA_BP=83
MMCEVMPTINEDTPMSQRGSQSSGSDSDSHFEQLMVNMLDERDRLLDTLRETQESLSLAQQRLQDVIYDRDSLQRQLNSALPQEPTGEPS

--------------------------------------------------------------

>67431_67431_41_PPFIA2-HMGA2_PPFIA2_chr12_82147751_ENST00000552948_HMGA2_chr12_66221780_ENST00000536545_length(amino acids)=193AA_BP=83
MMCEVMPTINEDTPMSQRGSQSSGSDSDSHFEQLMVNMLDERDRLLDTLRETQESLSLAQQRLQDVIYDRDSLQRQLNSALPQEPTGEPS
PKRPRGRPKGSKNKSPSKAAQKKAEATGEKRPRGRPRKWAGVQWYNLGSLQPPPPRFKQFSCLRLLSSWDYRHPPPHPANFCIFSRDRVS

--------------------------------------------------------------

>67431_67431_42_PPFIA2-HMGA2_PPFIA2_chr12_82147751_ENST00000552948_HMGA2_chr12_66221780_ENST00000541363_length(amino acids)=145AA_BP=83
MMCEVMPTINEDTPMSQRGSQSSGSDSDSHFEQLMVNMLDERDRLLDTLRETQESLSLAQQRLQDVIYDRDSLQRQLNSALPQEPTGEPS

--------------------------------------------------------------

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr12:82147751/chr12:66221780)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.HMGA2

P52926

FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Functions as a transcriptional regulator. Functions in cell cycle regulation through CCNA2. Plays an important role in chromosome condensation during the meiotic G2/M transition of spermatocytes. Plays a role in postnatal myogenesis, is involved in satellite cell activation (By similarity). Positively regulates IGF2 expression through PLAG1 and in a PLAG1-independent manner (PubMed:28796236). {ECO:0000250|UniProtKB:P52927, ECO:0000269|PubMed:14645522, ECO:0000269|PubMed:28796236}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneHMGA2chr12:82147751chr12:66221780ENST000003546360444_5437.0107.0DNA bindingNote=A.T hook 2
TgeneHMGA2chr12:82147751chr12:66221780ENST000003546360471_8237.0107.0DNA bindingNote=A.T hook 3
TgeneHMGA2chr12:82147751chr12:66221780ENST000003935780444_5437.091.0DNA bindingNote=A.T hook 2
TgeneHMGA2chr12:82147751chr12:66221780ENST000003935780471_8237.091.0DNA bindingNote=A.T hook 3
TgeneHMGA2chr12:82147751chr12:66221780ENST000004036810544_5437.0110.0DNA bindingNote=A.T hook 2
TgeneHMGA2chr12:82147751chr12:66221780ENST000004036810571_8237.0110.0DNA bindingNote=A.T hook 3
TgeneHMGA2chr12:82147751chr12:66221780ENST000004252080444_5437.093.0DNA bindingNote=A.T hook 2
TgeneHMGA2chr12:82147751chr12:66221780ENST000004252080471_8237.093.0DNA bindingNote=A.T hook 3

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePPFIA2chr12:82147751chr12:66221780ENST00000407050-1291081_110701033.6666666666667Coiled coilOntology_term=ECO:0000255
HgenePPFIA2chr12:82147751chr12:66221780ENST00000407050-129185_54101033.6666666666667Coiled coilOntology_term=ECO:0000255
HgenePPFIA2chr12:82147751chr12:66221780ENST00000407050-12929_15401033.6666666666667Coiled coilOntology_term=ECO:0000255
HgenePPFIA2chr12:82147751chr12:66221780ENST00000407050-129643_69501033.6666666666667Coiled coilOntology_term=ECO:0000255
HgenePPFIA2chr12:82147751chr12:66221780ENST00000443686-1281081_110701153.0Coiled coilOntology_term=ECO:0000255
HgenePPFIA2chr12:82147751chr12:66221780ENST00000443686-128185_54101153.0Coiled coilOntology_term=ECO:0000255
HgenePPFIA2chr12:82147751chr12:66221780ENST00000443686-12829_15401153.0Coiled coilOntology_term=ECO:0000255
HgenePPFIA2chr12:82147751chr12:66221780ENST00000443686-128643_69501153.0Coiled coilOntology_term=ECO:0000255
HgenePPFIA2chr12:82147751chr12:66221780ENST00000541017-1221081_11070557.6666666666666Coiled coilOntology_term=ECO:0000255
HgenePPFIA2chr12:82147751chr12:66221780ENST00000541017-122185_5410557.6666666666666Coiled coilOntology_term=ECO:0000255
HgenePPFIA2chr12:82147751chr12:66221780ENST00000541017-12229_1540557.6666666666666Coiled coilOntology_term=ECO:0000255
HgenePPFIA2chr12:82147751chr12:66221780ENST00000541017-122643_6950557.6666666666666Coiled coilOntology_term=ECO:0000255
HgenePPFIA2chr12:82147751chr12:66221780ENST00000541570-1201081_11070784.0Coiled coilOntology_term=ECO:0000255
HgenePPFIA2chr12:82147751chr12:66221780ENST00000541570-120185_5410784.0Coiled coilOntology_term=ECO:0000255
HgenePPFIA2chr12:82147751chr12:66221780ENST00000541570-12029_1540784.0Coiled coilOntology_term=ECO:0000255
HgenePPFIA2chr12:82147751chr12:66221780ENST00000541570-120643_6950784.0Coiled coilOntology_term=ECO:0000255
HgenePPFIA2chr12:82147751chr12:66221780ENST00000548586-2311081_110783.01252.0Coiled coilOntology_term=ECO:0000255
HgenePPFIA2chr12:82147751chr12:66221780ENST00000548586-231185_54183.01252.0Coiled coilOntology_term=ECO:0000255
HgenePPFIA2chr12:82147751chr12:66221780ENST00000548586-23129_15483.01252.0Coiled coilOntology_term=ECO:0000255
HgenePPFIA2chr12:82147751chr12:66221780ENST00000548586-231643_69583.01252.0Coiled coilOntology_term=ECO:0000255
HgenePPFIA2chr12:82147751chr12:66221780ENST00000549325-2311081_110783.01233.0Coiled coilOntology_term=ECO:0000255
HgenePPFIA2chr12:82147751chr12:66221780ENST00000549325-231185_54183.01233.0Coiled coilOntology_term=ECO:0000255
HgenePPFIA2chr12:82147751chr12:66221780ENST00000549325-23129_15483.01233.0Coiled coilOntology_term=ECO:0000255
HgenePPFIA2chr12:82147751chr12:66221780ENST00000549325-231643_69583.01233.0Coiled coilOntology_term=ECO:0000255
HgenePPFIA2chr12:82147751chr12:66221780ENST00000549396-3331081_110783.01700.6666666666667Coiled coilOntology_term=ECO:0000255
HgenePPFIA2chr12:82147751chr12:66221780ENST00000549396-333185_54183.01700.6666666666667Coiled coilOntology_term=ECO:0000255
HgenePPFIA2chr12:82147751chr12:66221780ENST00000549396-33329_15483.01700.6666666666667Coiled coilOntology_term=ECO:0000255
HgenePPFIA2chr12:82147751chr12:66221780ENST00000549396-333643_69583.01700.6666666666667Coiled coilOntology_term=ECO:0000255
HgenePPFIA2chr12:82147751chr12:66221780ENST00000552948-2301081_110783.01237.0Coiled coilOntology_term=ECO:0000255
HgenePPFIA2chr12:82147751chr12:66221780ENST00000552948-230185_54183.01237.0Coiled coilOntology_term=ECO:0000255
HgenePPFIA2chr12:82147751chr12:66221780ENST00000552948-23029_15483.01237.0Coiled coilOntology_term=ECO:0000255
HgenePPFIA2chr12:82147751chr12:66221780ENST00000552948-230643_69583.01237.0Coiled coilOntology_term=ECO:0000255
HgenePPFIA2chr12:82147751chr12:66221780ENST00000407050-129115_52801033.6666666666667Compositional biasNote=Glu-rich
HgenePPFIA2chr12:82147751chr12:66221780ENST00000407050-129622_62701033.6666666666667Compositional biasNote=Poly-Asp
HgenePPFIA2chr12:82147751chr12:66221780ENST00000443686-128115_52801153.0Compositional biasNote=Glu-rich
HgenePPFIA2chr12:82147751chr12:66221780ENST00000443686-128622_62701153.0Compositional biasNote=Poly-Asp
HgenePPFIA2chr12:82147751chr12:66221780ENST00000541017-122115_5280557.6666666666666Compositional biasNote=Glu-rich
HgenePPFIA2chr12:82147751chr12:66221780ENST00000541017-122622_6270557.6666666666666Compositional biasNote=Poly-Asp
HgenePPFIA2chr12:82147751chr12:66221780ENST00000541570-120115_5280784.0Compositional biasNote=Glu-rich
HgenePPFIA2chr12:82147751chr12:66221780ENST00000541570-120622_6270784.0Compositional biasNote=Poly-Asp
HgenePPFIA2chr12:82147751chr12:66221780ENST00000548586-231115_52883.01252.0Compositional biasNote=Glu-rich
HgenePPFIA2chr12:82147751chr12:66221780ENST00000548586-231622_62783.01252.0Compositional biasNote=Poly-Asp
HgenePPFIA2chr12:82147751chr12:66221780ENST00000549325-231115_52883.01233.0Compositional biasNote=Glu-rich
HgenePPFIA2chr12:82147751chr12:66221780ENST00000549325-231622_62783.01233.0Compositional biasNote=Poly-Asp
HgenePPFIA2chr12:82147751chr12:66221780ENST00000549396-333115_52883.01700.6666666666667Compositional biasNote=Glu-rich
HgenePPFIA2chr12:82147751chr12:66221780ENST00000549396-333622_62783.01700.6666666666667Compositional biasNote=Poly-Asp
HgenePPFIA2chr12:82147751chr12:66221780ENST00000552948-230115_52883.01237.0Compositional biasNote=Glu-rich
HgenePPFIA2chr12:82147751chr12:66221780ENST00000552948-230622_62783.01237.0Compositional biasNote=Poly-Asp
HgenePPFIA2chr12:82147751chr12:66221780ENST00000407050-1291020_108401033.6666666666667DomainSAM 2
HgenePPFIA2chr12:82147751chr12:66221780ENST00000407050-1291108_117701033.6666666666667DomainSAM 3
HgenePPFIA2chr12:82147751chr12:66221780ENST00000407050-129898_96401033.6666666666667DomainSAM 1
HgenePPFIA2chr12:82147751chr12:66221780ENST00000443686-1281020_108401153.0DomainSAM 2
HgenePPFIA2chr12:82147751chr12:66221780ENST00000443686-1281108_117701153.0DomainSAM 3
HgenePPFIA2chr12:82147751chr12:66221780ENST00000443686-128898_96401153.0DomainSAM 1
HgenePPFIA2chr12:82147751chr12:66221780ENST00000541017-1221020_10840557.6666666666666DomainSAM 2
HgenePPFIA2chr12:82147751chr12:66221780ENST00000541017-1221108_11770557.6666666666666DomainSAM 3
HgenePPFIA2chr12:82147751chr12:66221780ENST00000541017-122898_9640557.6666666666666DomainSAM 1
HgenePPFIA2chr12:82147751chr12:66221780ENST00000541570-1201020_10840784.0DomainSAM 2
HgenePPFIA2chr12:82147751chr12:66221780ENST00000541570-1201108_11770784.0DomainSAM 3
HgenePPFIA2chr12:82147751chr12:66221780ENST00000541570-120898_9640784.0DomainSAM 1
HgenePPFIA2chr12:82147751chr12:66221780ENST00000548586-2311020_108483.01252.0DomainSAM 2
HgenePPFIA2chr12:82147751chr12:66221780ENST00000548586-2311108_117783.01252.0DomainSAM 3
HgenePPFIA2chr12:82147751chr12:66221780ENST00000548586-231898_96483.01252.0DomainSAM 1
HgenePPFIA2chr12:82147751chr12:66221780ENST00000549325-2311020_108483.01233.0DomainSAM 2
HgenePPFIA2chr12:82147751chr12:66221780ENST00000549325-2311108_117783.01233.0DomainSAM 3
HgenePPFIA2chr12:82147751chr12:66221780ENST00000549325-231898_96483.01233.0DomainSAM 1
HgenePPFIA2chr12:82147751chr12:66221780ENST00000549396-3331020_108483.01700.6666666666667DomainSAM 2
HgenePPFIA2chr12:82147751chr12:66221780ENST00000549396-3331108_117783.01700.6666666666667DomainSAM 3
HgenePPFIA2chr12:82147751chr12:66221780ENST00000549396-333898_96483.01700.6666666666667DomainSAM 1
HgenePPFIA2chr12:82147751chr12:66221780ENST00000552948-2301020_108483.01237.0DomainSAM 2
HgenePPFIA2chr12:82147751chr12:66221780ENST00000552948-2301108_117783.01237.0DomainSAM 3
HgenePPFIA2chr12:82147751chr12:66221780ENST00000552948-230898_96483.01237.0DomainSAM 1
TgeneHMGA2chr12:82147751chr12:66221780ENST000003546360424_3437.0107.0DNA bindingNote=A.T hook 1
TgeneHMGA2chr12:82147751chr12:66221780ENST000003935780424_3437.091.0DNA bindingNote=A.T hook 1
TgeneHMGA2chr12:82147751chr12:66221780ENST000004036810524_3437.0110.0DNA bindingNote=A.T hook 1
TgeneHMGA2chr12:82147751chr12:66221780ENST000004252080424_3437.093.0DNA bindingNote=A.T hook 1


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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors
HMGA2RELA, NFKB1, PIAS3, RB1, PRMT6, NPM1, SMAD1, SMAD5, SMAD9, PRKCA, HDGF, PTBP1, APEX1, SYNCRIP, XRCC6, PSIP1, PA2G4, PCBP2, E4F1, OBSL1, HIST1H3A, CREB1, NFATC1, PCGF1, POU5F1, DLST, EZH2, SUZ12, MYC, TP53, MDM2, CSK, VRK1, HIST1H1B, PRKAG2, DUX4, DUX4L9, SYDE1, ARHGAP21, ARHGAP39, Plekhg5, ZNF263, MAFB, KAT2B, HIST1H2BG, LMNB1, NDUFAF7, CSNK2A1, LIG3, SUPT16H, VRK3, SP2, C1QBP, PARP2, TOP3A, CSNK2A2, XPC, RANBP17, PARP1, SUPV3L1, HIST2H2AC, HIST2H3PS2, KPNA4, USP7,


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
PPFIA2
HMGA2all structure


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to PPFIA2-HMGA2


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to PPFIA2-HMGA2


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneHMGA2C1519176Salivary Gland Pleomorphic Adenoma2ORPHANET
TgeneHMGA2C0005612Birth Weight1CTD_human
TgeneHMGA2C0006826Malignant Neoplasms1CTD_human
TgeneHMGA2C0027626Neoplasm Invasiveness1CTD_human
TgeneHMGA2C0027651Neoplasms1CTD_human
TgeneHMGA2C0086692Benign Neoplasm1CTD_human
TgeneHMGA2C0175693Russell-Silver syndrome1GENOMICS_ENGLAND
TgeneHMGA2C0473935Radiolabeled somatostatin analog study1GENOMICS_ENGLAND
TgeneHMGA2C0796160MENTAL RETARDATION, X-LINKED, SNYDER-ROBINSON TYPE1GENOMICS_ENGLAND
TgeneHMGA2C1096309Myolipoma1GENOMICS_ENGLAND
TgeneHMGA2C430514012q14 microdeletion syndrome1ORPHANET