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Center for Computational Systems Medicine level1
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:PPP1R12A-PAWR

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: PPP1R12A-PAWR
FusionPDB ID: 67753
FusionGDB2.0 ID: 67753
HgeneTgene
Gene symbol

PPP1R12A

PAWR

Gene ID

4659

5074

Gene nameprotein phosphatase 1 regulatory subunit 12Apro-apoptotic WT1 regulator
SynonymsGUBS|M130|MBS|MYPT1PAR4|Par-4
Cytomap

12q21.2-q21.31

12q21.2

Type of geneprotein-codingprotein-coding
Descriptionprotein phosphatase 1 regulatory subunit 12Amyosin binding subunitmyosin phosphatase, target subunit 1myosin phosphatase-targeting subunit 1protein phosphatase 1, regulatory (inhibitor) subunit 12Aprotein phosphatase myosin-binding subunitPRKC apoptosis WT1 regulator proteinPRKC, apoptosis, WT1, regulatorWT1-interacting proteinprostate apoptosis response protein 4prostate apoptosis response protein PAR-4prostate apoptosis response-4transcriptional repressor PAR4
Modification date2020032820200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST idsENST00000261207, ENST00000437004, 
ENST00000450142, ENST00000546369, 
ENST00000550107, 		ENST00000547571, 
ENST00000328827, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score25 X 22 X 11=605014 X 10 X 7=980
# samples 2816
** MAII scorelog2(28/6050*10)=-4.43343641010435
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(16/980*10)=-2.61470984411521
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: PPP1R12A [Title/Abstract] AND PAWR [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)PAWR(80083509)-PPP1R12A(80266718), # samples:2
PPP1R12A(80203575)-PAWR(80007389), # samples:1
PPP1R12A(80266588)-PAWR(80014987), # samples:1
PPP1R12A(80187643)-PAWR(80014987), # samples:1
PPP1R12A(80175595)-PAWR(80014987), # samples:1
PPP1R12A(80201006)-PAWR(80014987), # samples:1
PPP1R12A(80175595)-PAWR(80062188), # samples:1
Anticipated loss of major functional domain due to fusion event.PPP1R12A-PAWR seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
PPP1R12A-PAWR seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
PPP1R12A-PAWR seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
PPP1R12A-PAWR seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
PAWR-PPP1R12A seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
PAWR-PPP1R12A seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
PPP1R12A-PAWR seems lost the major protein functional domain in Tgene partner, which is a tumor suppressor due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgenePPP1R12A

GO:0030155

regulation of cell adhesion

20354225

HgenePPP1R12A

GO:0035507

regulation of myosin-light-chain-phosphatase activity

20354225

HgenePPP1R12A

GO:0043086

negative regulation of catalytic activity

19245366

HgenePPP1R12A

GO:0045944

positive regulation of transcription by RNA polymerase II

19245366


check buttonFusion gene breakpoints across PPP1R12A (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across PAWR (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BLCATCGA-ZF-A9RNPPP1R12Achr12

80203575

-PAWRchr12

80007389

-
ChimerDB4STADTCGA-CD-8526-01APPP1R12Achr12

80175595

-PAWRchr12

80014987

-
ChimerDB4STADTCGA-CD-8526-01APPP1R12Achr12

80175595

-PAWRchr12

80062188

-
ChimerDB4STADTCGA-CD-8526-01APPP1R12Achr12

80201006

-PAWRchr12

80014987

-
ChimerDB4STADTCGA-HU-A4HD-01APPP1R12Achr12

80187643

-PAWRchr12

80014987

-
ChimerDB4STADTCGA-HU-A4HD-01APPP1R12Achr12

80266588

-PAWRchr12

80014987

-


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000450142PPP1R12Achr1280203575-ENST00000328827PAWRchr1280007389-983017222672096609
ENST00000550107PPP1R12Achr1280203575-ENST00000328827PAWRchr1280007389-9563145501829609
ENST00000261207PPP1R12Achr1280266588-ENST00000328827PAWRchr1280014987-873149130497155
ENST00000437004PPP1R12Achr1280266588-ENST00000328827PAWRchr1280014987-873649635502155
ENST00000450142PPP1R12Achr1280187643-ENST00000328827PAWRchr1280014987-11156291626734221051
ENST00000550107PPP1R12Achr1280187643-ENST00000328827PAWRchr1280014987-10721248102987995
ENST00000450142PPP1R12Achr1280175595-ENST00000328827PAWRchr1280014987-11462322226737281153
ENST00000550107PPP1R12Achr1280175595-ENST00000328827PAWRchr1280014987-110272787032931097
ENST00000261207PPP1R12Achr1280201006-ENST00000328827PAWRchr1280014987-100181778301784584
ENST00000437004PPP1R12Achr1280201006-ENST00000328827PAWRchr1280014987-100231783351789584

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000450142ENST00000328827PPP1R12Achr1280203575-PAWRchr1280007389-0.0001479510.99985206
ENST00000550107ENST00000328827PPP1R12Achr1280203575-PAWRchr1280007389-0.0001453650.99985456
ENST00000261207ENST00000328827PPP1R12Achr1280266588-PAWRchr1280014987-0.0086818780.9913181
ENST00000437004ENST00000328827PPP1R12Achr1280266588-PAWRchr1280014987-0.00867540.99132466
ENST00000450142ENST00000328827PPP1R12Achr1280187643-PAWRchr1280014987-0.000102790.99989724
ENST00000550107ENST00000328827PPP1R12Achr1280187643-PAWRchr1280014987-9.49E-050.9999051
ENST00000450142ENST00000328827PPP1R12Achr1280175595-PAWRchr1280014987-0.0001302760.9998697
ENST00000550107ENST00000328827PPP1R12Achr1280175595-PAWRchr1280014987-5.62E-050.99994385
ENST00000261207ENST00000328827PPP1R12Achr1280201006-PAWRchr1280014987-0.0001605440.9998394
ENST00000437004ENST00000328827PPP1R12Achr1280201006-PAWRchr1280014987-0.0001615110.9998385

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>67753_67753_1_PPP1R12A-PAWR_PPP1R12A_chr12_80175595_ENST00000450142_PAWR_chr12_80014987_ENST00000328827_length(amino acids)=1153AA_BP=0
MKMADAKQKRNEQLKRWIGSETDLEPPVVKRQKTKVKFDDGAVFLAACSSGDTDEVLKLLHRGADINYANVDGLTALHQACIDDNVDMVK
FLVENGANINQPDNEGWIPLHAAASCGYLDIAEFLIGQGAHVGAVNSEGDTPLDIAEEEAMEELLQNEVNRQGVDIEAARKEEERIMLRD
ARQWLNSGHINDVRHAKSGGTALHVAAAKGYTEVLKLLIQAGYDVNIKDYDGWTPLHAAAHWGKEEACRILVDNLCDMEMVNKVGQTAFD
VADEDILGYLEELQKKQNLLHSEKRDKKSPLIESTANMDNNQSQKTFKNKETLIIEPEKNASRIESLEQEKVDEEEEGKKDESSCSSEED
EEDDSESEAETDKTKPLASVTNANTSSTQAAPVAVTTPTVSSGQATPTSPIKKFPTTATKISPKEEERKDESPATWRLGLRKTGSYGALA
EITASKEGQKEKDTAGVTRSASSPRLSSSLDNKEKEKDSKGTRLAYVAPTIPRRLASTSDIEEKENRDSSSLRTSSSYTRRKWEDDLKKN
SSVNEGSTYHKSCSFGRRQDDLISSSVPSTTSTPTVTSAAGLQKSLLSSTSTTTKITTGSSSAGTQSSTSNRLWAEDSTEKEKDSVPTAV
TIPVAPTVVNAAASTTTLTTTTAGTVSSTTEVRERRRSYLTPVRDEESESQRKARSRQARQSRRSTQGVTLTDLQEAEKTIGRSRSTRTR
EQENEEKEKEEKEKQDKEKQEEKKESETSREDEYKQKYSRTYDETYQRYRPVSTSSSTTPSSSLSTMSSSLYASSQLNRPNSLVGITSAY
SRGITKENEREGEKREEEKEGEDKSQPKSIRERRRPREKRRSTGVSFWTQDSDENEQEQQSDTEEGSNKKETQTDSISRYETSSTSAGDR
YDSLLGRSGSYSYLEERKPYSSRLEKDDSTDFKKLYEQILAENEKLKAQLHDTNMELTDLKLQLEKATQRQERFADRSLLEMEKRCLDEY
EDDEAGQKERKREDAITQQNTIQNEAVNLLDPGSSYLLQEPPRTVSGRYKSTTSVSEEDVSSRYSRTDRSGFPRYNRDANVSGTLVSSST

--------------------------------------------------------------

>67753_67753_2_PPP1R12A-PAWR_PPP1R12A_chr12_80175595_ENST00000550107_PAWR_chr12_80014987_ENST00000328827_length(amino acids)=1097AA_BP=0
MKMADAKQKRNEQLKRWIGSETDLEPPVVKRQKTKVKFDDGAVFLAACSSGDTDEVLKLLHRGADINYANVDGLTALHQACIDDNVDMVK
FLVENGANINQPDNEGWIPLHAAASCGYLDIAEFLIGQGAHVGAVNSEGDTPLDIAEEEAMEELLQNEVNRQGVDIEAARKEEERIMLRD
ARQWLNSGHINDVRHAKSGGTALHVAAAKGYTEVLKLLIQAGYDVNIKDYDGWTPLHAAAHWGKEEACRILVDNLCDMEMVNKVGQTAFD
VADEDILGYLEELQKKQNLLHSEKRDKKSPLIESTANMDNNQSQKTFKNKETLIIEPEKNASRIESLEQEKVDEEEEGKKDESSCSSEED
EEDDSESEAETDKTKPLASVTNANTSSTQAAPVAVTTPTVSSGQATPTSPIKKFPTTATKISPKEEERKDESPATWRLGLRKTGSYGALA
EITASKEGQKEKDTAGVTRSASSPRLSSSLDNKEKEKDSKGTRLAYVAPTIPRRLASTSDIEEKENRDSSSLRTSSSYTRRKWEDDLKKN
SSVNEGSTYHKSTSNRLWAEDSTEKEKDSVPTAVTIPVAPTVVNAAASTTTLTTTTAGTVSSTTEVRERRRSYLTPVRDEESESQRKARS
RQARQSRRSTQGVTLTDLQEAEKTIGRSRSTRTREQENEEKEKEEKEKQDKEKQEEKKESETSREDEYKQKYSRTYDETYQRYRPVSTSS
STTPSSSLSTMSSSLYASSQLNRPNSLVGITSAYSRGITKENEREGEKREEEKEGEDKSQPKSIRERRRPREKRRSTGVSFWTQDSDENE
QEQQSDTEEGSNKKETQTDSISRYETSSTSAGDRYDSLLGRSGSYSYLEERKPYSSRLEKDDSTDFKKLYEQILAENEKLKAQLHDTNME
LTDLKLQLEKATQRQERFADRSLLEMEKRCLDEYEDDEAGQKERKREDAITQQNTIQNEAVNLLDPGSSYLLQEPPRTVSGRYKSTTSVS
EEDVSSRYSRTDRSGFPRYNRDANVSGTLVSSSTLEKKIEDLEKEVVRERQENLRLVRLMQDKEEMIGKLKEEIDLLNRDLDDIEDENEQ

--------------------------------------------------------------

>67753_67753_3_PPP1R12A-PAWR_PPP1R12A_chr12_80187643_ENST00000450142_PAWR_chr12_80014987_ENST00000328827_length(amino acids)=1051AA_BP=0
MKMADAKQKRNEQLKRWIGSETDLEPPVVKRQKTKVKFDDGAVFLAACSSGDTDEVLKLLHRGADINYANVDGLTALHQACIDDNVDMVK
FLVENGANINQPDNEGWIPLHAAASCGYLDIAEFLIGQGAHVGAVNSEGDTPLDIAEEEAMEELLQNEVNRQGVDIEAARKEEERIMLRD
ARQWLNSGHINDVRHAKSGGTALHVAAAKGYTEVLKLLIQAGYDVNIKDYDGWTPLHAAAHWGKEEACRILVDNLCDMEMVNKVGQTAFD
VADEDILGYLEELQKKQNLLHSEKRDKKSPLIESTANMDNNQSQKTFKNKETLIIEPEKNASRIESLEQEKVDEEEEGKKDESSCSSEED
EEDDSESEAETDKTKPLASVTNANTSSTQAAPVAVTTPTVSSGQATPTSPIKKFPTTATKISPKEEERKDESPATWRLGLRKTGSYGALA
EITASKEGQKEKDTAGVTRSASSPRLSSSLDNKEKEKDSKGTRLAYVAPTIPRRLASTSDIEEKENRDSSSLRTSSSYTRRKWEDDLKKN
SSVNEGSTYHKSCSFGRRQDDLISSSVPSTTSTPTVTSAAGLQKSLLSSTSTTTKITTGSSSAGTQSSTSNRLWAEDSTEKEKDSVPTAV
TIPVAPTVVNAAASTTTLTTTTAGTVSSTTEVRERRRSYLTPVRDEESESQRKARSRQARQSRRSTQGVTLTDLQEAEKTIGRSRSTRTR
EQENEEKEKEEKEKQDKEKQEEKKESETSREDEYKQKYSRTYDETYQRYRPVSTSSSTTPSSSLSTMSSSLYASSQLNRPNSLVGITSAY
SRGITKENEREGEKREEEKEGEDKSQPKSIRERRRPREKRRSTGVSFWTQDSDENEQEQQSDTEEGSNKKETQCLDEYEDDEAGQKERKR
EDAITQQNTIQNEAVNLLDPGSSYLLQEPPRTVSGRYKSTTSVSEEDVSSRYSRTDRSGFPRYNRDANVSGTLVSSSTLEKKIEDLEKEV

--------------------------------------------------------------

>67753_67753_4_PPP1R12A-PAWR_PPP1R12A_chr12_80187643_ENST00000550107_PAWR_chr12_80014987_ENST00000328827_length(amino acids)=995AA_BP=0
MKMADAKQKRNEQLKRWIGSETDLEPPVVKRQKTKVKFDDGAVFLAACSSGDTDEVLKLLHRGADINYANVDGLTALHQACIDDNVDMVK
FLVENGANINQPDNEGWIPLHAAASCGYLDIAEFLIGQGAHVGAVNSEGDTPLDIAEEEAMEELLQNEVNRQGVDIEAARKEEERIMLRD
ARQWLNSGHINDVRHAKSGGTALHVAAAKGYTEVLKLLIQAGYDVNIKDYDGWTPLHAAAHWGKEEACRILVDNLCDMEMVNKVGQTAFD
VADEDILGYLEELQKKQNLLHSEKRDKKSPLIESTANMDNNQSQKTFKNKETLIIEPEKNASRIESLEQEKVDEEEEGKKDESSCSSEED
EEDDSESEAETDKTKPLASVTNANTSSTQAAPVAVTTPTVSSGQATPTSPIKKFPTTATKISPKEEERKDESPATWRLGLRKTGSYGALA
EITASKEGQKEKDTAGVTRSASSPRLSSSLDNKEKEKDSKGTRLAYVAPTIPRRLASTSDIEEKENRDSSSLRTSSSYTRRKWEDDLKKN
SSVNEGSTYHKSTSNRLWAEDSTEKEKDSVPTAVTIPVAPTVVNAAASTTTLTTTTAGTVSSTTEVRERRRSYLTPVRDEESESQRKARS
RQARQSRRSTQGVTLTDLQEAEKTIGRSRSTRTREQENEEKEKEEKEKQDKEKQEEKKESETSREDEYKQKYSRTYDETYQRYRPVSTSS
STTPSSSLSTMSSSLYASSQLNRPNSLVGITSAYSRGITKENEREGEKREEEKEGEDKSQPKSIRERRRPREKRRSTGVSFWTQDSDENE
QEQQSDTEEGSNKKETQCLDEYEDDEAGQKERKREDAITQQNTIQNEAVNLLDPGSSYLLQEPPRTVSGRYKSTTSVSEEDVSSRYSRTD
RSGFPRYNRDANVSGTLVSSSTLEKKIEDLEKEVVRERQENLRLVRLMQDKEEMIGKLKEEIDLLNRDLDDIEDENEQLKQENKTLLKVV

--------------------------------------------------------------

>67753_67753_5_PPP1R12A-PAWR_PPP1R12A_chr12_80201006_ENST00000261207_PAWR_chr12_80014987_ENST00000328827_length(amino acids)=584AA_BP=
MLASGFPGAPSPTGQPSFPASSFPDPAAGEGMKMADAKQKRNEQLKRWIGSETDLEPPVVKRQKTKVKFDDGAVFLAACSSGDTDEVLKL
LHRGADINYANVDGLTALHQACIDDNVDMVKFLVENGANINQPDNEGWIPLHAAASCGYLDIAEFLIGQGAHVGAVNSEGDTPLDIAEEE
AMEELLQNEVNRQGVDIEAARKEEERIMLRDARQWLNSGHINDVRHAKSGGTALHVAAAKGYTEVLKLLIQAGYDVNIKDYDGWTPLHAA
AHWGKEEACRILVDNLCDMEMVNKVGQTAFDVADEDILGYLEELQKKQNLLHSEKRDKKSPLIESTANMDNNQSQKTFKNKETLIIEPEK
NASRIESLEQEKVDEEEEGKKDESSCSSEEDEEDDSESEAETDKTKPLASVTNANTSSTQAAPVAVTTPTVSSGQATPTSPIKKFPTTAT
KISPKEEERKDESPATWRLGLRKTGSYGALAEITASKEGQKEKDTAGVTRSASSPRLSSSLDNKEKEKDSKGTRLAYVAPTIPRRLASTS

--------------------------------------------------------------

>67753_67753_6_PPP1R12A-PAWR_PPP1R12A_chr12_80201006_ENST00000437004_PAWR_chr12_80014987_ENST00000328827_length(amino acids)=584AA_BP=
MLASGFPGAPSPTGQPSFPASSFPDPAAGEGMKMADAKQKRNEQLKRWIGSETDLEPPVVKRQKTKVKFDDGAVFLAACSSGDTDEVLKL
LHRGADINYANVDGLTALHQACIDDNVDMVKFLVENGANINQPDNEGWIPLHAAASCGYLDIAEFLIGQGAHVGAVNSEGDTPLDIAEEE
AMEELLQNEVNRQGVDIEAARKEEERIMLRDARQWLNSGHINDVRHAKSGGTALHVAAAKGYTEVLKLLIQAGYDVNIKDYDGWTPLHAA
AHWGKEEACRILVDNLCDMEMVNKVGQTAFDVADEDILGYLEELQKKQNLLHSEKRDKKSPLIESTANMDNNQSQKTFKNKETLIIEPEK
NASRIESLEQEKVDEEEEGKKDESSCSSEEDEEDDSESEAETDKTKPLASVTNANTSSTQAAPVAVTTPTVSSGQATPTSPIKKFPTTAT
KISPKEEERKDESPATWRLGLRKTGSYGALAEITASKEGQKEKDTAGVTRSASSPRLSSSLDNKEKEKDSKGTRLAYVAPTIPRRLASTS

--------------------------------------------------------------

>67753_67753_7_PPP1R12A-PAWR_PPP1R12A_chr12_80203575_ENST00000450142_PAWR_chr12_80007389_ENST00000328827_length(amino acids)=609AA_BP=0
MKMADAKQKRNEQLKRWIGSETDLEPPVVKRQKTKVKFDDGAVFLAACSSGDTDEVLKLLHRGADINYANVDGLTALHQACIDDNVDMVK
FLVENGANINQPDNEGWIPLHAAASCGYLDIAEFLIGQGAHVGAVNSEGDTPLDIAEEEAMEELLQNEVNRQGVDIEAARKEEERIMLRD
ARQWLNSGHINDVRHAKSGGTALHVAAAKGYTEVLKLLIQAGYDVNIKDYDGWTPLHAAAHWGKEEACRILVDNLCDMEMVNKVGQTAFD
VADEDILGYLEELQKKQNLLHSEKRDKKSPLIESTANMDNNQSQKTFKNKETLIIEPEKNASRIESLEQEKVDEEEEGKKDESSCSSEED
EEDDSESEAETDKTKPLASVTNANTSSTQAAPVAVTTPTVSSGQATPTSPIKKFPTTATKISPKEEERKDESPATWRLGLRKTGSYGALA
EITASKEGQKEKDTAGVTRSASSPRLSSSLDNKEKEPPRTVSGRYKSTTSVSEEDVSSRYSRTDRSGFPRYNRDANVSGTLVSSSTLEKK

--------------------------------------------------------------

>67753_67753_8_PPP1R12A-PAWR_PPP1R12A_chr12_80203575_ENST00000550107_PAWR_chr12_80007389_ENST00000328827_length(amino acids)=609AA_BP=0
MKMADAKQKRNEQLKRWIGSETDLEPPVVKRQKTKVKFDDGAVFLAACSSGDTDEVLKLLHRGADINYANVDGLTALHQACIDDNVDMVK
FLVENGANINQPDNEGWIPLHAAASCGYLDIAEFLIGQGAHVGAVNSEGDTPLDIAEEEAMEELLQNEVNRQGVDIEAARKEEERIMLRD
ARQWLNSGHINDVRHAKSGGTALHVAAAKGYTEVLKLLIQAGYDVNIKDYDGWTPLHAAAHWGKEEACRILVDNLCDMEMVNKVGQTAFD
VADEDILGYLEELQKKQNLLHSEKRDKKSPLIESTANMDNNQSQKTFKNKETLIIEPEKNASRIESLEQEKVDEEEEGKKDESSCSSEED
EEDDSESEAETDKTKPLASVTNANTSSTQAAPVAVTTPTVSSGQATPTSPIKKFPTTATKISPKEEERKDESPATWRLGLRKTGSYGALA
EITASKEGQKEKDTAGVTRSASSPRLSSSLDNKEKEPPRTVSGRYKSTTSVSEEDVSSRYSRTDRSGFPRYNRDANVSGTLVSSSTLEKK

--------------------------------------------------------------

>67753_67753_9_PPP1R12A-PAWR_PPP1R12A_chr12_80266588_ENST00000261207_PAWR_chr12_80014987_ENST00000328827_length(amino acids)=155AA_BP=
MLASGFPGAPSPTGQPSFPASSFPDPAAGEGMKMADAKQKRNEQLKRWIGSETDLEPPVVKRQKTKVKFDDGAVFLAACSSGDTDEVLKL

--------------------------------------------------------------

>67753_67753_10_PPP1R12A-PAWR_PPP1R12A_chr12_80266588_ENST00000437004_PAWR_chr12_80014987_ENST00000328827_length(amino acids)=155AA_BP=
MLASGFPGAPSPTGQPSFPASSFPDPAAGEGMKMADAKQKRNEQLKRWIGSETDLEPPVVKRQKTKVKFDDGAVFLAACSSGDTDEVLKL

--------------------------------------------------------------

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr12:80083509/chr12:80266718)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePPP1R12Achr12:80175595chr12:80014987ENST00000261207-2426519_660985.01031.0Compositional biasNote=Ser/Thr-rich
HgenePPP1R12Achr12:80175595chr12:80014987ENST00000261207-2426721_753985.01031.0Compositional biasNote=Glu/Lys-rich
HgenePPP1R12Achr12:80175595chr12:80014987ENST00000261207-2426773_795985.01031.0Compositional biasNote=Ser-rich
HgenePPP1R12Achr12:80175595chr12:80014987ENST00000437004-2325519_660950.0996.0Compositional biasNote=Ser/Thr-rich
HgenePPP1R12Achr12:80175595chr12:80014987ENST00000437004-2325721_753950.0996.0Compositional biasNote=Glu/Lys-rich
HgenePPP1R12Achr12:80175595chr12:80014987ENST00000437004-2325773_795950.0996.0Compositional biasNote=Ser-rich
HgenePPP1R12Achr12:80175595chr12:80014987ENST00000450142-2325519_660985.01031.0Compositional biasNote=Ser/Thr-rich
HgenePPP1R12Achr12:80175595chr12:80014987ENST00000450142-2325721_753985.01031.0Compositional biasNote=Glu/Lys-rich
HgenePPP1R12Achr12:80175595chr12:80014987ENST00000450142-2325773_795985.01031.0Compositional biasNote=Ser-rich
HgenePPP1R12Achr12:80175595chr12:80014987ENST00000546369-2325519_660898.0944.0Compositional biasNote=Ser/Thr-rich
HgenePPP1R12Achr12:80175595chr12:80014987ENST00000546369-2325721_753898.0944.0Compositional biasNote=Glu/Lys-rich
HgenePPP1R12Achr12:80175595chr12:80014987ENST00000546369-2325773_795898.0944.0Compositional biasNote=Ser-rich
HgenePPP1R12Achr12:80175595chr12:80014987ENST00000550107-2224519_660929.0975.0Compositional biasNote=Ser/Thr-rich
HgenePPP1R12Achr12:80175595chr12:80014987ENST00000550107-2224721_753929.0975.0Compositional biasNote=Glu/Lys-rich
HgenePPP1R12Achr12:80175595chr12:80014987ENST00000550107-2224773_795929.0975.0Compositional biasNote=Ser-rich
HgenePPP1R12Achr12:80187643chr12:80014987ENST00000261207-2026519_660883.01031.0Compositional biasNote=Ser/Thr-rich
HgenePPP1R12Achr12:80187643chr12:80014987ENST00000261207-2026721_753883.01031.0Compositional biasNote=Glu/Lys-rich
HgenePPP1R12Achr12:80187643chr12:80014987ENST00000261207-2026773_795883.01031.0Compositional biasNote=Ser-rich
HgenePPP1R12Achr12:80187643chr12:80014987ENST00000437004-2025519_660883.0996.0Compositional biasNote=Ser/Thr-rich
HgenePPP1R12Achr12:80187643chr12:80014987ENST00000437004-2025721_753883.0996.0Compositional biasNote=Glu/Lys-rich
HgenePPP1R12Achr12:80187643chr12:80014987ENST00000437004-2025773_795883.0996.0Compositional biasNote=Ser-rich
HgenePPP1R12Achr12:80187643chr12:80014987ENST00000450142-1925519_660883.01031.0Compositional biasNote=Ser/Thr-rich
HgenePPP1R12Achr12:80187643chr12:80014987ENST00000450142-1925721_753883.01031.0Compositional biasNote=Glu/Lys-rich
HgenePPP1R12Achr12:80187643chr12:80014987ENST00000450142-1925773_795883.01031.0Compositional biasNote=Ser-rich
HgenePPP1R12Achr12:80187643chr12:80014987ENST00000546369-1925519_660796.0944.0Compositional biasNote=Ser/Thr-rich
HgenePPP1R12Achr12:80187643chr12:80014987ENST00000546369-1925721_753796.0944.0Compositional biasNote=Glu/Lys-rich
HgenePPP1R12Achr12:80187643chr12:80014987ENST00000546369-1925773_795796.0944.0Compositional biasNote=Ser-rich
HgenePPP1R12Achr12:80187643chr12:80014987ENST00000550107-1824519_660827.0975.0Compositional biasNote=Ser/Thr-rich
HgenePPP1R12Achr12:80187643chr12:80014987ENST00000550107-1824721_753827.0975.0Compositional biasNote=Glu/Lys-rich
HgenePPP1R12Achr12:80187643chr12:80014987ENST00000550107-1824773_795827.0975.0Compositional biasNote=Ser-rich
HgenePPP1R12Achr12:80175595chr12:80014987ENST00000261207-242635_38985.01031.0MotifNote=KVKF motif
HgenePPP1R12Achr12:80175595chr12:80014987ENST00000437004-232535_38950.0996.0MotifNote=KVKF motif
HgenePPP1R12Achr12:80175595chr12:80014987ENST00000450142-232535_38985.01031.0MotifNote=KVKF motif
HgenePPP1R12Achr12:80175595chr12:80014987ENST00000546369-232535_38898.0944.0MotifNote=KVKF motif
HgenePPP1R12Achr12:80175595chr12:80014987ENST00000550107-222435_38929.0975.0MotifNote=KVKF motif
HgenePPP1R12Achr12:80187643chr12:80014987ENST00000261207-202635_38883.01031.0MotifNote=KVKF motif
HgenePPP1R12Achr12:80187643chr12:80014987ENST00000437004-202535_38883.0996.0MotifNote=KVKF motif
HgenePPP1R12Achr12:80187643chr12:80014987ENST00000450142-192535_38883.01031.0MotifNote=KVKF motif
HgenePPP1R12Achr12:80187643chr12:80014987ENST00000546369-192535_38796.0944.0MotifNote=KVKF motif
HgenePPP1R12Achr12:80187643chr12:80014987ENST00000550107-182435_38827.0975.0MotifNote=KVKF motif
HgenePPP1R12Achr12:80201006chr12:80014987ENST00000261207-132635_38551.66666666666661031.0MotifNote=KVKF motif
HgenePPP1R12Achr12:80201006chr12:80014987ENST00000437004-132535_38551.6666666666666996.0MotifNote=KVKF motif
HgenePPP1R12Achr12:80201006chr12:80014987ENST00000450142-122535_38551.66666666666661031.0MotifNote=KVKF motif
HgenePPP1R12Achr12:80201006chr12:80014987ENST00000546369-122535_38464.6666666666667944.0MotifNote=KVKF motif
HgenePPP1R12Achr12:80201006chr12:80014987ENST00000550107-122435_38551.6666666666666975.0MotifNote=KVKF motif
HgenePPP1R12Achr12:80203575chr12:80007389ENST00000261207-112635_38485.01031.0MotifNote=KVKF motif
HgenePPP1R12Achr12:80203575chr12:80007389ENST00000437004-112535_38485.0996.0MotifNote=KVKF motif
HgenePPP1R12Achr12:80203575chr12:80007389ENST00000450142-102535_38485.01031.0MotifNote=KVKF motif
HgenePPP1R12Achr12:80203575chr12:80007389ENST00000546369-102535_38398.0944.0MotifNote=KVKF motif
HgenePPP1R12Achr12:80203575chr12:80007389ENST00000550107-102435_38485.0975.0MotifNote=KVKF motif
HgenePPP1R12Achr12:80266588chr12:80014987ENST00000261207-32635_38122.666666666666671031.0MotifNote=KVKF motif
HgenePPP1R12Achr12:80266588chr12:80014987ENST00000437004-32535_38122.66666666666667996.0MotifNote=KVKF motif
HgenePPP1R12Achr12:80266588chr12:80014987ENST00000450142-22535_38122.666666666666671031.0MotifNote=KVKF motif
HgenePPP1R12Achr12:80266588chr12:80014987ENST00000546369-22535_3835.666666666666664944.0MotifNote=KVKF motif
HgenePPP1R12Achr12:80266588chr12:80014987ENST00000550107-22435_38122.66666666666667975.0MotifNote=KVKF motif
HgenePPP1R12Achr12:80175595chr12:80014987ENST00000261207-2426105_134985.01031.0RepeatNote=ANK 3
HgenePPP1R12Achr12:80175595chr12:80014987ENST00000261207-2426138_164985.01031.0RepeatNote=ANK 4
HgenePPP1R12Achr12:80175595chr12:80014987ENST00000261207-2426198_227985.01031.0RepeatNote=ANK 5
HgenePPP1R12Achr12:80175595chr12:80014987ENST00000261207-2426231_260985.01031.0RepeatNote=ANK 6
HgenePPP1R12Achr12:80175595chr12:80014987ENST00000261207-242639_68985.01031.0RepeatNote=ANK 1
HgenePPP1R12Achr12:80175595chr12:80014987ENST00000261207-242672_101985.01031.0RepeatNote=ANK 2
HgenePPP1R12Achr12:80175595chr12:80014987ENST00000437004-2325105_134950.0996.0RepeatNote=ANK 3
HgenePPP1R12Achr12:80175595chr12:80014987ENST00000437004-2325138_164950.0996.0RepeatNote=ANK 4
HgenePPP1R12Achr12:80175595chr12:80014987ENST00000437004-2325198_227950.0996.0RepeatNote=ANK 5
HgenePPP1R12Achr12:80175595chr12:80014987ENST00000437004-2325231_260950.0996.0RepeatNote=ANK 6
HgenePPP1R12Achr12:80175595chr12:80014987ENST00000437004-232539_68950.0996.0RepeatNote=ANK 1
HgenePPP1R12Achr12:80175595chr12:80014987ENST00000437004-232572_101950.0996.0RepeatNote=ANK 2
HgenePPP1R12Achr12:80175595chr12:80014987ENST00000450142-2325105_134985.01031.0RepeatNote=ANK 3
HgenePPP1R12Achr12:80175595chr12:80014987ENST00000450142-2325138_164985.01031.0RepeatNote=ANK 4
HgenePPP1R12Achr12:80175595chr12:80014987ENST00000450142-2325198_227985.01031.0RepeatNote=ANK 5
HgenePPP1R12Achr12:80175595chr12:80014987ENST00000450142-2325231_260985.01031.0RepeatNote=ANK 6
HgenePPP1R12Achr12:80175595chr12:80014987ENST00000450142-232539_68985.01031.0RepeatNote=ANK 1
HgenePPP1R12Achr12:80175595chr12:80014987ENST00000450142-232572_101985.01031.0RepeatNote=ANK 2
HgenePPP1R12Achr12:80175595chr12:80014987ENST00000546369-2325105_134898.0944.0RepeatNote=ANK 3
HgenePPP1R12Achr12:80175595chr12:80014987ENST00000546369-2325138_164898.0944.0RepeatNote=ANK 4
HgenePPP1R12Achr12:80175595chr12:80014987ENST00000546369-2325198_227898.0944.0RepeatNote=ANK 5
HgenePPP1R12Achr12:80175595chr12:80014987ENST00000546369-2325231_260898.0944.0RepeatNote=ANK 6
HgenePPP1R12Achr12:80175595chr12:80014987ENST00000546369-232539_68898.0944.0RepeatNote=ANK 1
HgenePPP1R12Achr12:80175595chr12:80014987ENST00000546369-232572_101898.0944.0RepeatNote=ANK 2
HgenePPP1R12Achr12:80175595chr12:80014987ENST00000550107-2224105_134929.0975.0RepeatNote=ANK 3
HgenePPP1R12Achr12:80175595chr12:80014987ENST00000550107-2224138_164929.0975.0RepeatNote=ANK 4
HgenePPP1R12Achr12:80175595chr12:80014987ENST00000550107-2224198_227929.0975.0RepeatNote=ANK 5
HgenePPP1R12Achr12:80175595chr12:80014987ENST00000550107-2224231_260929.0975.0RepeatNote=ANK 6
HgenePPP1R12Achr12:80175595chr12:80014987ENST00000550107-222439_68929.0975.0RepeatNote=ANK 1
HgenePPP1R12Achr12:80175595chr12:80014987ENST00000550107-222472_101929.0975.0RepeatNote=ANK 2
HgenePPP1R12Achr12:80187643chr12:80014987ENST00000261207-2026105_134883.01031.0RepeatNote=ANK 3
HgenePPP1R12Achr12:80187643chr12:80014987ENST00000261207-2026138_164883.01031.0RepeatNote=ANK 4
HgenePPP1R12Achr12:80187643chr12:80014987ENST00000261207-2026198_227883.01031.0RepeatNote=ANK 5
HgenePPP1R12Achr12:80187643chr12:80014987ENST00000261207-2026231_260883.01031.0RepeatNote=ANK 6
HgenePPP1R12Achr12:80187643chr12:80014987ENST00000261207-202639_68883.01031.0RepeatNote=ANK 1
HgenePPP1R12Achr12:80187643chr12:80014987ENST00000261207-202672_101883.01031.0RepeatNote=ANK 2
HgenePPP1R12Achr12:80187643chr12:80014987ENST00000437004-2025105_134883.0996.0RepeatNote=ANK 3
HgenePPP1R12Achr12:80187643chr12:80014987ENST00000437004-2025138_164883.0996.0RepeatNote=ANK 4
HgenePPP1R12Achr12:80187643chr12:80014987ENST00000437004-2025198_227883.0996.0RepeatNote=ANK 5
HgenePPP1R12Achr12:80187643chr12:80014987ENST00000437004-2025231_260883.0996.0RepeatNote=ANK 6
HgenePPP1R12Achr12:80187643chr12:80014987ENST00000437004-202539_68883.0996.0RepeatNote=ANK 1
HgenePPP1R12Achr12:80187643chr12:80014987ENST00000437004-202572_101883.0996.0RepeatNote=ANK 2
HgenePPP1R12Achr12:80187643chr12:80014987ENST00000450142-1925105_134883.01031.0RepeatNote=ANK 3
HgenePPP1R12Achr12:80187643chr12:80014987ENST00000450142-1925138_164883.01031.0RepeatNote=ANK 4
HgenePPP1R12Achr12:80187643chr12:80014987ENST00000450142-1925198_227883.01031.0RepeatNote=ANK 5
HgenePPP1R12Achr12:80187643chr12:80014987ENST00000450142-1925231_260883.01031.0RepeatNote=ANK 6
HgenePPP1R12Achr12:80187643chr12:80014987ENST00000450142-192539_68883.01031.0RepeatNote=ANK 1
HgenePPP1R12Achr12:80187643chr12:80014987ENST00000450142-192572_101883.01031.0RepeatNote=ANK 2
HgenePPP1R12Achr12:80187643chr12:80014987ENST00000546369-1925105_134796.0944.0RepeatNote=ANK 3
HgenePPP1R12Achr12:80187643chr12:80014987ENST00000546369-1925138_164796.0944.0RepeatNote=ANK 4
HgenePPP1R12Achr12:80187643chr12:80014987ENST00000546369-1925198_227796.0944.0RepeatNote=ANK 5
HgenePPP1R12Achr12:80187643chr12:80014987ENST00000546369-1925231_260796.0944.0RepeatNote=ANK 6
HgenePPP1R12Achr12:80187643chr12:80014987ENST00000546369-192539_68796.0944.0RepeatNote=ANK 1
HgenePPP1R12Achr12:80187643chr12:80014987ENST00000546369-192572_101796.0944.0RepeatNote=ANK 2
HgenePPP1R12Achr12:80187643chr12:80014987ENST00000550107-1824105_134827.0975.0RepeatNote=ANK 3
HgenePPP1R12Achr12:80187643chr12:80014987ENST00000550107-1824138_164827.0975.0RepeatNote=ANK 4
HgenePPP1R12Achr12:80187643chr12:80014987ENST00000550107-1824198_227827.0975.0RepeatNote=ANK 5
HgenePPP1R12Achr12:80187643chr12:80014987ENST00000550107-1824231_260827.0975.0RepeatNote=ANK 6
HgenePPP1R12Achr12:80187643chr12:80014987ENST00000550107-182439_68827.0975.0RepeatNote=ANK 1
HgenePPP1R12Achr12:80187643chr12:80014987ENST00000550107-182472_101827.0975.0RepeatNote=ANK 2
HgenePPP1R12Achr12:80201006chr12:80014987ENST00000261207-1326105_134551.66666666666661031.0RepeatNote=ANK 3
HgenePPP1R12Achr12:80201006chr12:80014987ENST00000261207-1326138_164551.66666666666661031.0RepeatNote=ANK 4
HgenePPP1R12Achr12:80201006chr12:80014987ENST00000261207-1326198_227551.66666666666661031.0RepeatNote=ANK 5
HgenePPP1R12Achr12:80201006chr12:80014987ENST00000261207-1326231_260551.66666666666661031.0RepeatNote=ANK 6
HgenePPP1R12Achr12:80201006chr12:80014987ENST00000261207-132639_68551.66666666666661031.0RepeatNote=ANK 1
HgenePPP1R12Achr12:80201006chr12:80014987ENST00000261207-132672_101551.66666666666661031.0RepeatNote=ANK 2
HgenePPP1R12Achr12:80201006chr12:80014987ENST00000437004-1325105_134551.6666666666666996.0RepeatNote=ANK 3
HgenePPP1R12Achr12:80201006chr12:80014987ENST00000437004-1325138_164551.6666666666666996.0RepeatNote=ANK 4
HgenePPP1R12Achr12:80201006chr12:80014987ENST00000437004-1325198_227551.6666666666666996.0RepeatNote=ANK 5
HgenePPP1R12Achr12:80201006chr12:80014987ENST00000437004-1325231_260551.6666666666666996.0RepeatNote=ANK 6
HgenePPP1R12Achr12:80201006chr12:80014987ENST00000437004-132539_68551.6666666666666996.0RepeatNote=ANK 1
HgenePPP1R12Achr12:80201006chr12:80014987ENST00000437004-132572_101551.6666666666666996.0RepeatNote=ANK 2
HgenePPP1R12Achr12:80201006chr12:80014987ENST00000450142-1225105_134551.66666666666661031.0RepeatNote=ANK 3
HgenePPP1R12Achr12:80201006chr12:80014987ENST00000450142-1225138_164551.66666666666661031.0RepeatNote=ANK 4
HgenePPP1R12Achr12:80201006chr12:80014987ENST00000450142-1225198_227551.66666666666661031.0RepeatNote=ANK 5
HgenePPP1R12Achr12:80201006chr12:80014987ENST00000450142-1225231_260551.66666666666661031.0RepeatNote=ANK 6
HgenePPP1R12Achr12:80201006chr12:80014987ENST00000450142-122539_68551.66666666666661031.0RepeatNote=ANK 1
HgenePPP1R12Achr12:80201006chr12:80014987ENST00000450142-122572_101551.66666666666661031.0RepeatNote=ANK 2
HgenePPP1R12Achr12:80201006chr12:80014987ENST00000546369-1225105_134464.6666666666667944.0RepeatNote=ANK 3
HgenePPP1R12Achr12:80201006chr12:80014987ENST00000546369-1225138_164464.6666666666667944.0RepeatNote=ANK 4
HgenePPP1R12Achr12:80201006chr12:80014987ENST00000546369-1225198_227464.6666666666667944.0RepeatNote=ANK 5
HgenePPP1R12Achr12:80201006chr12:80014987ENST00000546369-1225231_260464.6666666666667944.0RepeatNote=ANK 6
HgenePPP1R12Achr12:80201006chr12:80014987ENST00000546369-122539_68464.6666666666667944.0RepeatNote=ANK 1
HgenePPP1R12Achr12:80201006chr12:80014987ENST00000546369-122572_101464.6666666666667944.0RepeatNote=ANK 2
HgenePPP1R12Achr12:80201006chr12:80014987ENST00000550107-1224105_134551.6666666666666975.0RepeatNote=ANK 3
HgenePPP1R12Achr12:80201006chr12:80014987ENST00000550107-1224138_164551.6666666666666975.0RepeatNote=ANK 4
HgenePPP1R12Achr12:80201006chr12:80014987ENST00000550107-1224198_227551.6666666666666975.0RepeatNote=ANK 5
HgenePPP1R12Achr12:80201006chr12:80014987ENST00000550107-1224231_260551.6666666666666975.0RepeatNote=ANK 6
HgenePPP1R12Achr12:80201006chr12:80014987ENST00000550107-122439_68551.6666666666666975.0RepeatNote=ANK 1
HgenePPP1R12Achr12:80201006chr12:80014987ENST00000550107-122472_101551.6666666666666975.0RepeatNote=ANK 2
HgenePPP1R12Achr12:80203575chr12:80007389ENST00000261207-1126105_134485.01031.0RepeatNote=ANK 3
HgenePPP1R12Achr12:80203575chr12:80007389ENST00000261207-1126138_164485.01031.0RepeatNote=ANK 4
HgenePPP1R12Achr12:80203575chr12:80007389ENST00000261207-1126198_227485.01031.0RepeatNote=ANK 5
HgenePPP1R12Achr12:80203575chr12:80007389ENST00000261207-1126231_260485.01031.0RepeatNote=ANK 6
HgenePPP1R12Achr12:80203575chr12:80007389ENST00000261207-112639_68485.01031.0RepeatNote=ANK 1
HgenePPP1R12Achr12:80203575chr12:80007389ENST00000261207-112672_101485.01031.0RepeatNote=ANK 2
HgenePPP1R12Achr12:80203575chr12:80007389ENST00000437004-1125105_134485.0996.0RepeatNote=ANK 3
HgenePPP1R12Achr12:80203575chr12:80007389ENST00000437004-1125138_164485.0996.0RepeatNote=ANK 4
HgenePPP1R12Achr12:80203575chr12:80007389ENST00000437004-1125198_227485.0996.0RepeatNote=ANK 5
HgenePPP1R12Achr12:80203575chr12:80007389ENST00000437004-1125231_260485.0996.0RepeatNote=ANK 6
HgenePPP1R12Achr12:80203575chr12:80007389ENST00000437004-112539_68485.0996.0RepeatNote=ANK 1
HgenePPP1R12Achr12:80203575chr12:80007389ENST00000437004-112572_101485.0996.0RepeatNote=ANK 2
HgenePPP1R12Achr12:80203575chr12:80007389ENST00000450142-1025105_134485.01031.0RepeatNote=ANK 3
HgenePPP1R12Achr12:80203575chr12:80007389ENST00000450142-1025138_164485.01031.0RepeatNote=ANK 4
HgenePPP1R12Achr12:80203575chr12:80007389ENST00000450142-1025198_227485.01031.0RepeatNote=ANK 5
HgenePPP1R12Achr12:80203575chr12:80007389ENST00000450142-1025231_260485.01031.0RepeatNote=ANK 6
HgenePPP1R12Achr12:80203575chr12:80007389ENST00000450142-102539_68485.01031.0RepeatNote=ANK 1
HgenePPP1R12Achr12:80203575chr12:80007389ENST00000450142-102572_101485.01031.0RepeatNote=ANK 2
HgenePPP1R12Achr12:80203575chr12:80007389ENST00000546369-1025105_134398.0944.0RepeatNote=ANK 3
HgenePPP1R12Achr12:80203575chr12:80007389ENST00000546369-1025138_164398.0944.0RepeatNote=ANK 4
HgenePPP1R12Achr12:80203575chr12:80007389ENST00000546369-1025198_227398.0944.0RepeatNote=ANK 5
HgenePPP1R12Achr12:80203575chr12:80007389ENST00000546369-1025231_260398.0944.0RepeatNote=ANK 6
HgenePPP1R12Achr12:80203575chr12:80007389ENST00000546369-102539_68398.0944.0RepeatNote=ANK 1
HgenePPP1R12Achr12:80203575chr12:80007389ENST00000546369-102572_101398.0944.0RepeatNote=ANK 2
HgenePPP1R12Achr12:80203575chr12:80007389ENST00000550107-1024105_134485.0975.0RepeatNote=ANK 3
HgenePPP1R12Achr12:80203575chr12:80007389ENST00000550107-1024138_164485.0975.0RepeatNote=ANK 4
HgenePPP1R12Achr12:80203575chr12:80007389ENST00000550107-1024198_227485.0975.0RepeatNote=ANK 5
HgenePPP1R12Achr12:80203575chr12:80007389ENST00000550107-1024231_260485.0975.0RepeatNote=ANK 6
HgenePPP1R12Achr12:80203575chr12:80007389ENST00000550107-102439_68485.0975.0RepeatNote=ANK 1
HgenePPP1R12Achr12:80203575chr12:80007389ENST00000550107-102472_101485.0975.0RepeatNote=ANK 2
HgenePPP1R12Achr12:80266588chr12:80014987ENST00000261207-32639_68122.666666666666671031.0RepeatNote=ANK 1
HgenePPP1R12Achr12:80266588chr12:80014987ENST00000261207-32672_101122.666666666666671031.0RepeatNote=ANK 2
HgenePPP1R12Achr12:80266588chr12:80014987ENST00000437004-32539_68122.66666666666667996.0RepeatNote=ANK 1
HgenePPP1R12Achr12:80266588chr12:80014987ENST00000437004-32572_101122.66666666666667996.0RepeatNote=ANK 2
HgenePPP1R12Achr12:80266588chr12:80014987ENST00000450142-22539_68122.666666666666671031.0RepeatNote=ANK 1
HgenePPP1R12Achr12:80266588chr12:80014987ENST00000450142-22572_101122.666666666666671031.0RepeatNote=ANK 2
HgenePPP1R12Achr12:80266588chr12:80014987ENST00000550107-22439_68122.66666666666667975.0RepeatNote=ANK 1
HgenePPP1R12Achr12:80266588chr12:80014987ENST00000550107-22472_101122.66666666666667975.0RepeatNote=ANK 2
TgenePAWRchr12:80175595chr12:80014987ENST0000032882717186_206172.0341.0Coiled coilOntology_term=ECO:0000255
TgenePAWRchr12:80187643chr12:80014987ENST0000032882717186_206172.0341.0Coiled coilOntology_term=ECO:0000255
TgenePAWRchr12:80201006chr12:80014987ENST0000032882717186_206172.0341.0Coiled coilOntology_term=ECO:0000255
TgenePAWRchr12:80266588chr12:80014987ENST0000032882717186_206172.0341.0Coiled coilOntology_term=ECO:0000255
TgenePAWRchr12:80175595chr12:80014987ENST0000032882717300_340172.0341.0RegionNote=Leucine-zipper
TgenePAWRchr12:80187643chr12:80014987ENST0000032882717300_340172.0341.0RegionNote=Leucine-zipper
TgenePAWRchr12:80201006chr12:80014987ENST0000032882717300_340172.0341.0RegionNote=Leucine-zipper
TgenePAWRchr12:80203575chr12:80007389ENST0000032882727300_340216.0341.0RegionNote=Leucine-zipper
TgenePAWRchr12:80266588chr12:80014987ENST0000032882717300_340172.0341.0RegionNote=Leucine-zipper

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePPP1R12Achr12:80201006chr12:80014987ENST00000261207-1326519_660551.66666666666661031.0Compositional biasNote=Ser/Thr-rich
HgenePPP1R12Achr12:80201006chr12:80014987ENST00000261207-1326721_753551.66666666666661031.0Compositional biasNote=Glu/Lys-rich
HgenePPP1R12Achr12:80201006chr12:80014987ENST00000261207-1326773_795551.66666666666661031.0Compositional biasNote=Ser-rich
HgenePPP1R12Achr12:80201006chr12:80014987ENST00000437004-1325519_660551.6666666666666996.0Compositional biasNote=Ser/Thr-rich
HgenePPP1R12Achr12:80201006chr12:80014987ENST00000437004-1325721_753551.6666666666666996.0Compositional biasNote=Glu/Lys-rich
HgenePPP1R12Achr12:80201006chr12:80014987ENST00000437004-1325773_795551.6666666666666996.0Compositional biasNote=Ser-rich
HgenePPP1R12Achr12:80201006chr12:80014987ENST00000450142-1225519_660551.66666666666661031.0Compositional biasNote=Ser/Thr-rich
HgenePPP1R12Achr12:80201006chr12:80014987ENST00000450142-1225721_753551.66666666666661031.0Compositional biasNote=Glu/Lys-rich
HgenePPP1R12Achr12:80201006chr12:80014987ENST00000450142-1225773_795551.66666666666661031.0Compositional biasNote=Ser-rich
HgenePPP1R12Achr12:80201006chr12:80014987ENST00000546369-1225519_660464.6666666666667944.0Compositional biasNote=Ser/Thr-rich
HgenePPP1R12Achr12:80201006chr12:80014987ENST00000546369-1225721_753464.6666666666667944.0Compositional biasNote=Glu/Lys-rich
HgenePPP1R12Achr12:80201006chr12:80014987ENST00000546369-1225773_795464.6666666666667944.0Compositional biasNote=Ser-rich
HgenePPP1R12Achr12:80201006chr12:80014987ENST00000550107-1224519_660551.6666666666666975.0Compositional biasNote=Ser/Thr-rich
HgenePPP1R12Achr12:80201006chr12:80014987ENST00000550107-1224721_753551.6666666666666975.0Compositional biasNote=Glu/Lys-rich
HgenePPP1R12Achr12:80201006chr12:80014987ENST00000550107-1224773_795551.6666666666666975.0Compositional biasNote=Ser-rich
HgenePPP1R12Achr12:80203575chr12:80007389ENST00000261207-1126519_660485.01031.0Compositional biasNote=Ser/Thr-rich
HgenePPP1R12Achr12:80203575chr12:80007389ENST00000261207-1126721_753485.01031.0Compositional biasNote=Glu/Lys-rich
HgenePPP1R12Achr12:80203575chr12:80007389ENST00000261207-1126773_795485.01031.0Compositional biasNote=Ser-rich
HgenePPP1R12Achr12:80203575chr12:80007389ENST00000437004-1125519_660485.0996.0Compositional biasNote=Ser/Thr-rich
HgenePPP1R12Achr12:80203575chr12:80007389ENST00000437004-1125721_753485.0996.0Compositional biasNote=Glu/Lys-rich
HgenePPP1R12Achr12:80203575chr12:80007389ENST00000437004-1125773_795485.0996.0Compositional biasNote=Ser-rich
HgenePPP1R12Achr12:80203575chr12:80007389ENST00000450142-1025519_660485.01031.0Compositional biasNote=Ser/Thr-rich
HgenePPP1R12Achr12:80203575chr12:80007389ENST00000450142-1025721_753485.01031.0Compositional biasNote=Glu/Lys-rich
HgenePPP1R12Achr12:80203575chr12:80007389ENST00000450142-1025773_795485.01031.0Compositional biasNote=Ser-rich
HgenePPP1R12Achr12:80203575chr12:80007389ENST00000546369-1025519_660398.0944.0Compositional biasNote=Ser/Thr-rich
HgenePPP1R12Achr12:80203575chr12:80007389ENST00000546369-1025721_753398.0944.0Compositional biasNote=Glu/Lys-rich
HgenePPP1R12Achr12:80203575chr12:80007389ENST00000546369-1025773_795398.0944.0Compositional biasNote=Ser-rich
HgenePPP1R12Achr12:80203575chr12:80007389ENST00000550107-1024519_660485.0975.0Compositional biasNote=Ser/Thr-rich
HgenePPP1R12Achr12:80203575chr12:80007389ENST00000550107-1024721_753485.0975.0Compositional biasNote=Glu/Lys-rich
HgenePPP1R12Achr12:80203575chr12:80007389ENST00000550107-1024773_795485.0975.0Compositional biasNote=Ser-rich
HgenePPP1R12Achr12:80266588chr12:80014987ENST00000261207-326519_660122.666666666666671031.0Compositional biasNote=Ser/Thr-rich
HgenePPP1R12Achr12:80266588chr12:80014987ENST00000261207-326721_753122.666666666666671031.0Compositional biasNote=Glu/Lys-rich
HgenePPP1R12Achr12:80266588chr12:80014987ENST00000261207-326773_795122.666666666666671031.0Compositional biasNote=Ser-rich
HgenePPP1R12Achr12:80266588chr12:80014987ENST00000437004-325519_660122.66666666666667996.0Compositional biasNote=Ser/Thr-rich
HgenePPP1R12Achr12:80266588chr12:80014987ENST00000437004-325721_753122.66666666666667996.0Compositional biasNote=Glu/Lys-rich
HgenePPP1R12Achr12:80266588chr12:80014987ENST00000437004-325773_795122.66666666666667996.0Compositional biasNote=Ser-rich
HgenePPP1R12Achr12:80266588chr12:80014987ENST00000450142-225519_660122.666666666666671031.0Compositional biasNote=Ser/Thr-rich
HgenePPP1R12Achr12:80266588chr12:80014987ENST00000450142-225721_753122.666666666666671031.0Compositional biasNote=Glu/Lys-rich
HgenePPP1R12Achr12:80266588chr12:80014987ENST00000450142-225773_795122.666666666666671031.0Compositional biasNote=Ser-rich
HgenePPP1R12Achr12:80266588chr12:80014987ENST00000546369-225519_66035.666666666666664944.0Compositional biasNote=Ser/Thr-rich
HgenePPP1R12Achr12:80266588chr12:80014987ENST00000546369-225721_75335.666666666666664944.0Compositional biasNote=Glu/Lys-rich
HgenePPP1R12Achr12:80266588chr12:80014987ENST00000546369-225773_79535.666666666666664944.0Compositional biasNote=Ser-rich
HgenePPP1R12Achr12:80266588chr12:80014987ENST00000550107-224519_660122.66666666666667975.0Compositional biasNote=Ser/Thr-rich
HgenePPP1R12Achr12:80266588chr12:80014987ENST00000550107-224721_753122.66666666666667975.0Compositional biasNote=Glu/Lys-rich
HgenePPP1R12Achr12:80266588chr12:80014987ENST00000550107-224773_795122.66666666666667975.0Compositional biasNote=Ser-rich
HgenePPP1R12Achr12:80266588chr12:80014987ENST00000261207-326105_134122.666666666666671031.0RepeatNote=ANK 3
HgenePPP1R12Achr12:80266588chr12:80014987ENST00000261207-326138_164122.666666666666671031.0RepeatNote=ANK 4
HgenePPP1R12Achr12:80266588chr12:80014987ENST00000261207-326198_227122.666666666666671031.0RepeatNote=ANK 5
HgenePPP1R12Achr12:80266588chr12:80014987ENST00000261207-326231_260122.666666666666671031.0RepeatNote=ANK 6
HgenePPP1R12Achr12:80266588chr12:80014987ENST00000437004-325105_134122.66666666666667996.0RepeatNote=ANK 3
HgenePPP1R12Achr12:80266588chr12:80014987ENST00000437004-325138_164122.66666666666667996.0RepeatNote=ANK 4
HgenePPP1R12Achr12:80266588chr12:80014987ENST00000437004-325198_227122.66666666666667996.0RepeatNote=ANK 5
HgenePPP1R12Achr12:80266588chr12:80014987ENST00000437004-325231_260122.66666666666667996.0RepeatNote=ANK 6
HgenePPP1R12Achr12:80266588chr12:80014987ENST00000450142-225105_134122.666666666666671031.0RepeatNote=ANK 3
HgenePPP1R12Achr12:80266588chr12:80014987ENST00000450142-225138_164122.666666666666671031.0RepeatNote=ANK 4
HgenePPP1R12Achr12:80266588chr12:80014987ENST00000450142-225198_227122.666666666666671031.0RepeatNote=ANK 5
HgenePPP1R12Achr12:80266588chr12:80014987ENST00000450142-225231_260122.666666666666671031.0RepeatNote=ANK 6
HgenePPP1R12Achr12:80266588chr12:80014987ENST00000546369-225105_13435.666666666666664944.0RepeatNote=ANK 3
HgenePPP1R12Achr12:80266588chr12:80014987ENST00000546369-225138_16435.666666666666664944.0RepeatNote=ANK 4
HgenePPP1R12Achr12:80266588chr12:80014987ENST00000546369-225198_22735.666666666666664944.0RepeatNote=ANK 5
HgenePPP1R12Achr12:80266588chr12:80014987ENST00000546369-225231_26035.666666666666664944.0RepeatNote=ANK 6
HgenePPP1R12Achr12:80266588chr12:80014987ENST00000546369-22539_6835.666666666666664944.0RepeatNote=ANK 1
HgenePPP1R12Achr12:80266588chr12:80014987ENST00000546369-22572_10135.666666666666664944.0RepeatNote=ANK 2
HgenePPP1R12Achr12:80266588chr12:80014987ENST00000550107-224105_134122.66666666666667975.0RepeatNote=ANK 3
HgenePPP1R12Achr12:80266588chr12:80014987ENST00000550107-224138_164122.66666666666667975.0RepeatNote=ANK 4
HgenePPP1R12Achr12:80266588chr12:80014987ENST00000550107-224198_227122.66666666666667975.0RepeatNote=ANK 5
HgenePPP1R12Achr12:80266588chr12:80014987ENST00000550107-224231_260122.66666666666667975.0RepeatNote=ANK 6
TgenePAWRchr12:80203575chr12:80007389ENST0000032882727186_206216.0341.0Coiled coilOntology_term=ECO:0000255
TgenePAWRchr12:80175595chr12:80014987ENST000003288271749_120172.0341.0Compositional biasNote=Ala-rich
TgenePAWRchr12:80187643chr12:80014987ENST000003288271749_120172.0341.0Compositional biasNote=Ala-rich
TgenePAWRchr12:80201006chr12:80014987ENST000003288271749_120172.0341.0Compositional biasNote=Ala-rich
TgenePAWRchr12:80203575chr12:80007389ENST000003288272749_120216.0341.0Compositional biasNote=Ala-rich
TgenePAWRchr12:80266588chr12:80014987ENST000003288271749_120172.0341.0Compositional biasNote=Ala-rich
TgenePAWRchr12:80175595chr12:80014987ENST0000032882717145_161172.0341.0MotifNuclear localization signal
TgenePAWRchr12:80175595chr12:80014987ENST000003288271768_72172.0341.0MotifB30.2/SPRY domain-binding motif
TgenePAWRchr12:80187643chr12:80014987ENST0000032882717145_161172.0341.0MotifNuclear localization signal
TgenePAWRchr12:80187643chr12:80014987ENST000003288271768_72172.0341.0MotifB30.2/SPRY domain-binding motif
TgenePAWRchr12:80201006chr12:80014987ENST0000032882717145_161172.0341.0MotifNuclear localization signal
TgenePAWRchr12:80201006chr12:80014987ENST000003288271768_72172.0341.0MotifB30.2/SPRY domain-binding motif
TgenePAWRchr12:80203575chr12:80007389ENST0000032882727145_161216.0341.0MotifNuclear localization signal
TgenePAWRchr12:80203575chr12:80007389ENST000003288272768_72216.0341.0MotifB30.2/SPRY domain-binding motif
TgenePAWRchr12:80266588chr12:80014987ENST0000032882717145_161172.0341.0MotifNuclear localization signal
TgenePAWRchr12:80266588chr12:80014987ENST000003288271768_72172.0341.0MotifB30.2/SPRY domain-binding motif
TgenePAWRchr12:80175595chr12:80014987ENST0000032882717145_203172.0341.0RegionNote=Selective for apoptosis induction in cancer cells (SAC)
TgenePAWRchr12:80187643chr12:80014987ENST0000032882717145_203172.0341.0RegionNote=Selective for apoptosis induction in cancer cells (SAC)
TgenePAWRchr12:80201006chr12:80014987ENST0000032882717145_203172.0341.0RegionNote=Selective for apoptosis induction in cancer cells (SAC)
TgenePAWRchr12:80203575chr12:80007389ENST0000032882727145_203216.0341.0RegionNote=Selective for apoptosis induction in cancer cells (SAC)
TgenePAWRchr12:80266588chr12:80014987ENST0000032882717145_203172.0341.0RegionNote=Selective for apoptosis induction in cancer cells (SAC)


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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
PPP1R12A
PAWR


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgenePPP1R12Achr12:80187643chr12:80014987ENST00000546369-1925682_864796.0944.0ROCK2
HgenePPP1R12Achr12:80187643chr12:80014987ENST00000550107-1824682_864827.0975.0ROCK2
HgenePPP1R12Achr12:80201006chr12:80014987ENST00000261207-1326682_864551.66666666666661031.0ROCK2
HgenePPP1R12Achr12:80201006chr12:80014987ENST00000437004-1325682_864551.6666666666666996.0ROCK2
HgenePPP1R12Achr12:80201006chr12:80014987ENST00000450142-1225682_864551.66666666666661031.0ROCK2
HgenePPP1R12Achr12:80201006chr12:80014987ENST00000546369-1225682_864464.6666666666667944.0ROCK2
HgenePPP1R12Achr12:80201006chr12:80014987ENST00000550107-1224682_864551.6666666666666975.0ROCK2
HgenePPP1R12Achr12:80203575chr12:80007389ENST00000261207-1126682_864485.01031.0ROCK2
HgenePPP1R12Achr12:80203575chr12:80007389ENST00000437004-1125682_864485.0996.0ROCK2
HgenePPP1R12Achr12:80203575chr12:80007389ENST00000450142-1025682_864485.01031.0ROCK2
HgenePPP1R12Achr12:80203575chr12:80007389ENST00000546369-1025682_864398.0944.0ROCK2
HgenePPP1R12Achr12:80203575chr12:80007389ENST00000550107-1024682_864485.0975.0ROCK2
HgenePPP1R12Achr12:80266588chr12:80014987ENST00000261207-326682_864122.666666666666671031.0ROCK2
HgenePPP1R12Achr12:80266588chr12:80014987ENST00000437004-325682_864122.66666666666667996.0ROCK2
HgenePPP1R12Achr12:80266588chr12:80014987ENST00000450142-225682_864122.666666666666671031.0ROCK2
HgenePPP1R12Achr12:80266588chr12:80014987ENST00000546369-225682_86435.666666666666664944.0ROCK2
HgenePPP1R12Achr12:80266588chr12:80014987ENST00000550107-224682_864122.66666666666667975.0ROCK2


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Related Drugs to PPP1R12A-PAWR


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to PPP1R12A-PAWR


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource