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Center for Computational Systems Medicine level1
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:PPP1R1B-ACLY

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: PPP1R1B-ACLY
FusionPDB ID: 67863
FusionGDB2.0 ID: 67863
HgeneTgene
Gene symbol

PPP1R1B

ACLY

Gene ID

84152

47

Gene nameprotein phosphatase 1 regulatory inhibitor subunit 1BATP citrate lyase
SynonymsDARPP-32|DARPP32ACL|ATPCL|CLATP
Cytomap

17q12

17q21.2

Type of geneprotein-codingprotein-coding
Descriptionprotein phosphatase 1 regulatory subunit 1Bdopamine and cAMP-regulated neuronal phosphoprotein 32ATP-citrate synthaseATP-citrate (pro-S-)-lyasecitrate cleavage enzyme
Modification date2020031320200313
UniProtAcc.

P53396

Ensembl transtripts involved in fusion geneENST idsENST00000254079, ENST00000394265, 
ENST00000394267, ENST00000579000, 
ENST00000580825, 		ENST00000588779, 
ENST00000352035, ENST00000353196, 
ENST00000393896, ENST00000537919, 
ENST00000590151, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score11 X 11 X 6=72613 X 13 X 6=1014
# samples 1115
** MAII scorelog2(11/726*10)=-2.72246602447109
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(15/1014*10)=-2.75702324650746
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: PPP1R1B [Title/Abstract] AND ACLY [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)PPP1R1B(37790339)-ACLY(40058066), # samples:2
Anticipated loss of major functional domain due to fusion event.PPP1R1B-ACLY seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
PPP1R1B-ACLY seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
PPP1R1B-ACLY seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
PPP1R1B-ACLY seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
PPP1R1B-ACLY seems lost the major protein functional domain in Hgene partner, which is a tumor suppressor due to the frame-shifted ORF.
PPP1R1B-ACLY seems lost the major protein functional domain in Tgene partner, which is a cell metabolism gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgenePPP1R1B

GO:0032515

negative regulation of phosphoprotein phosphatase activity

10807923

TgeneACLY

GO:0006085

acetyl-CoA biosynthetic process

1371749

TgeneACLY

GO:0006101

citrate metabolic process

1371749

TgeneACLY

GO:0006107

oxaloacetate metabolic process

1371749

TgeneACLY

GO:0008610

lipid biosynthetic process

23932781


check buttonFusion gene breakpoints across PPP1R1B (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across ACLY (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4STADTCGA-VQ-A91X-01APPP1R1Bchr17

37790339

+ACLYchr17

40055038

-
ChimerDB4STADTCGA-VQ-A91X-01APPP1R1Bchr17

37790339

+ACLYchr17

40058066

-
ChimerDB4STADTCGA-VQ-A91XPPP1R1Bchr17

37790339

+ACLYchr17

40058066

-


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000580825PPP1R1Bchr1737790339+ENST00000352035ACLYchr1740055038-37587332882855855
ENST00000580825PPP1R1Bchr1737790339+ENST00000590151ACLYchr1740055038-37497332882855855
ENST00000580825PPP1R1Bchr1737790339+ENST00000353196ACLYchr1740055038-37057332882825845
ENST00000580825PPP1R1Bchr1737790339+ENST00000537919ACLYchr1740055038-31807332882825845
ENST00000580825PPP1R1Bchr1737790339+ENST00000393896ACLYchr1740055038-30627332882825845
ENST00000254079PPP1R1Bchr1737790339+ENST00000352035ACLYchr1740055038-3939914430361010
ENST00000254079PPP1R1Bchr1737790339+ENST00000590151ACLYchr1740055038-3930914430361010
ENST00000254079PPP1R1Bchr1737790339+ENST00000353196ACLYchr1740055038-3886914430061000
ENST00000254079PPP1R1Bchr1737790339+ENST00000537919ACLYchr1740055038-3361914430061000
ENST00000254079PPP1R1Bchr1737790339+ENST00000393896ACLYchr1740055038-3243914430061000
ENST00000579000PPP1R1Bchr1737790339+ENST00000352035ACLYchr1740055038-35645391932661822
ENST00000579000PPP1R1Bchr1737790339+ENST00000590151ACLYchr1740055038-35555391932661822
ENST00000579000PPP1R1Bchr1737790339+ENST00000353196ACLYchr1740055038-35115391932631812
ENST00000579000PPP1R1Bchr1737790339+ENST00000537919ACLYchr1740055038-29865391932631812
ENST00000579000PPP1R1Bchr1737790339+ENST00000393896ACLYchr1740055038-28685391932631812
ENST00000394265PPP1R1Bchr1737790339+ENST00000352035ACLYchr1740055038-3514489502611853
ENST00000394265PPP1R1Bchr1737790339+ENST00000590151ACLYchr1740055038-3505489502611853
ENST00000394265PPP1R1Bchr1737790339+ENST00000353196ACLYchr1740055038-3461489502581843
ENST00000394265PPP1R1Bchr1737790339+ENST00000537919ACLYchr1740055038-2936489502581843
ENST00000394265PPP1R1Bchr1737790339+ENST00000393896ACLYchr1740055038-2818489502581843
ENST00000394267PPP1R1Bchr1737790339+ENST00000352035ACLYchr1740055038-35985732362695819
ENST00000394267PPP1R1Bchr1737790339+ENST00000590151ACLYchr1740055038-35895732362695819
ENST00000394267PPP1R1Bchr1737790339+ENST00000353196ACLYchr1740055038-35455732362665809
ENST00000394267PPP1R1Bchr1737790339+ENST00000537919ACLYchr1740055038-30205732362665809
ENST00000394267PPP1R1Bchr1737790339+ENST00000393896ACLYchr1740055038-29025732362665809

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000580825ENST00000352035PPP1R1Bchr1737790339+ACLYchr1740055038-0.0021057880.9978942
ENST00000580825ENST00000590151PPP1R1Bchr1737790339+ACLYchr1740055038-0.0020989350.9979011
ENST00000580825ENST00000353196PPP1R1Bchr1737790339+ACLYchr1740055038-0.0019409450.9980591
ENST00000580825ENST00000537919PPP1R1Bchr1737790339+ACLYchr1740055038-0.0051101210.99488986
ENST00000580825ENST00000393896PPP1R1Bchr1737790339+ACLYchr1740055038-0.005792280.99420774
ENST00000254079ENST00000352035PPP1R1Bchr1737790339+ACLYchr1740055038-0.0021898840.9978102
ENST00000254079ENST00000590151PPP1R1Bchr1737790339+ACLYchr1740055038-0.0021707870.99782914
ENST00000254079ENST00000353196PPP1R1Bchr1737790339+ACLYchr1740055038-0.0020129110.99798703
ENST00000254079ENST00000537919PPP1R1Bchr1737790339+ACLYchr1740055038-0.0048852850.9951147
ENST00000254079ENST00000393896PPP1R1Bchr1737790339+ACLYchr1740055038-0.0051857850.9948143
ENST00000579000ENST00000352035PPP1R1Bchr1737790339+ACLYchr1740055038-0.0022888420.9977112
ENST00000579000ENST00000590151PPP1R1Bchr1737790339+ACLYchr1740055038-0.0022856510.9977144
ENST00000579000ENST00000353196PPP1R1Bchr1737790339+ACLYchr1740055038-0.0020418090.9979582
ENST00000579000ENST00000537919PPP1R1Bchr1737790339+ACLYchr1740055038-0.0045546190.9954454
ENST00000579000ENST00000393896PPP1R1Bchr1737790339+ACLYchr1740055038-0.00598790.99401206
ENST00000394265ENST00000352035PPP1R1Bchr1737790339+ACLYchr1740055038-0.0009968430.99900323
ENST00000394265ENST00000590151PPP1R1Bchr1737790339+ACLYchr1740055038-0.0009917890.99900824
ENST00000394265ENST00000353196PPP1R1Bchr1737790339+ACLYchr1740055038-0.0008142130.99918574
ENST00000394265ENST00000537919PPP1R1Bchr1737790339+ACLYchr1740055038-0.0024025110.9975975
ENST00000394265ENST00000393896PPP1R1Bchr1737790339+ACLYchr1740055038-0.0027553230.9972447
ENST00000394267ENST00000352035PPP1R1Bchr1737790339+ACLYchr1740055038-0.0010481430.9989518
ENST00000394267ENST00000590151PPP1R1Bchr1737790339+ACLYchr1740055038-0.0010389890.998961
ENST00000394267ENST00000353196PPP1R1Bchr1737790339+ACLYchr1740055038-0.0008604740.99913955
ENST00000394267ENST00000537919PPP1R1Bchr1737790339+ACLYchr1740055038-0.0025141050.9974859
ENST00000394267ENST00000393896PPP1R1Bchr1737790339+ACLYchr1740055038-0.0028906690.99710935

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>67863_67863_1_PPP1R1B-ACLY_PPP1R1B_chr17_37790339_ENST00000254079_ACLY_chr17_40055038_ENST00000352035_length(amino acids)=1010AA_BP=303
MGPEGEPGRGRDTRGEEERLREGGGEGRERQREETRRDTQEGRDTETQRHSGGERHRDAETPRPGSARERGTDLAQRARGASPESREPGG
APSPGADPPPAPAPSPRRARYFYPCANSPPPPLAAQPAACAGEPSTDRRRDPESRTPAPPPTPRAMDPKDRKKIQFSVPAPPSQLDPRQV
EMIRRRRPTPAMLFRLSEHSSPEEEASPHQRASGEGHHLKSKRPNPCAYTPPSLKAVQRIAESHLQSISNLNENQASEEEDELGELRELG
YPREEDEEEEEDDEEEEEEEDSQAEVLKVIRQSGKTTGIPIHVFGTETHMTAIVGMALGHRPIPNQPPTAAHTANFLLNASGSTSTPAPS
RTASFSESRADEVAPAKKAKPAMPQDSVPSPRSLQGKSTTLFSRHTKAIVWGMQTRAVQGMLDFDYVCSRDEPSVAAMVYPFTGDHKQKF
YWGHKEILIPVFKNMADAMRKHPEVDVLINFASLRSAYDSTMETMNYAQIRTIAIIAEGIPEALTRKLIKKADQKGVTIIGPATVGGIKP
GCFKIGNTGGMLDNILASKLYRPGSVAYVSRSGGMSNELNNIISRTTDGVYEGVAIGGDRYPGSTFMDHVLRYQDTPGVKMIVVLGEIGG
TEEYKICRGIKEGRLTKPIVCWCIGTCATMFSSEVQFGHAGACANQASETAVAKNQALKEAGVFVPRSFDELGEIIQSVYEDLVANGVIV
PAQEVPPPTVPMDYSWARELGLIRKPASFMTSICDERGQELIYAGMPITEVFKEEMGIGGVLGLLWFQKRLPKYSCQFIEMCLMVTADHG
PAVSGAHNTIICARAGKDLVSSLTSGLLTIGDRFGGALDAAAKMFSKAFDSGIIPMEFVNKMKKEGKLIMGIGHRVKSINNPDMRVQILK
DYVRQHFPATPLLDYALEVEKITTSKKPNLILNVDGLIGVAFVDMLRNCGSFTREEADEYIDIGALNGIFVLGRSMGFIGHYLDQKRLKQ

--------------------------------------------------------------

>67863_67863_2_PPP1R1B-ACLY_PPP1R1B_chr17_37790339_ENST00000254079_ACLY_chr17_40055038_ENST00000353196_length(amino acids)=1000AA_BP=303
MGPEGEPGRGRDTRGEEERLREGGGEGRERQREETRRDTQEGRDTETQRHSGGERHRDAETPRPGSARERGTDLAQRARGASPESREPGG
APSPGADPPPAPAPSPRRARYFYPCANSPPPPLAAQPAACAGEPSTDRRRDPESRTPAPPPTPRAMDPKDRKKIQFSVPAPPSQLDPRQV
EMIRRRRPTPAMLFRLSEHSSPEEEASPHQRASGEGHHLKSKRPNPCAYTPPSLKAVQRIAESHLQSISNLNENQASEEEDELGELRELG
YPREEDEEEEEDDEEEEEEEDSQAEVLKVIRQSGKTTGIPIHVFGTETHMTAIVGMALGHRPIPNQPPTAAHTANFLLNASGSTSTPAPS
RTASFSESRADEVAPAKKAKPAMPQGKSTTLFSRHTKAIVWGMQTRAVQGMLDFDYVCSRDEPSVAAMVYPFTGDHKQKFYWGHKEILIP
VFKNMADAMRKHPEVDVLINFASLRSAYDSTMETMNYAQIRTIAIIAEGIPEALTRKLIKKADQKGVTIIGPATVGGIKPGCFKIGNTGG
MLDNILASKLYRPGSVAYVSRSGGMSNELNNIISRTTDGVYEGVAIGGDRYPGSTFMDHVLRYQDTPGVKMIVVLGEIGGTEEYKICRGI
KEGRLTKPIVCWCIGTCATMFSSEVQFGHAGACANQASETAVAKNQALKEAGVFVPRSFDELGEIIQSVYEDLVANGVIVPAQEVPPPTV
PMDYSWARELGLIRKPASFMTSICDERGQELIYAGMPITEVFKEEMGIGGVLGLLWFQKRLPKYSCQFIEMCLMVTADHGPAVSGAHNTI
ICARAGKDLVSSLTSGLLTIGDRFGGALDAAAKMFSKAFDSGIIPMEFVNKMKKEGKLIMGIGHRVKSINNPDMRVQILKDYVRQHFPAT
PLLDYALEVEKITTSKKPNLILNVDGLIGVAFVDMLRNCGSFTREEADEYIDIGALNGIFVLGRSMGFIGHYLDQKRLKQGLYRHPWDDI

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>67863_67863_3_PPP1R1B-ACLY_PPP1R1B_chr17_37790339_ENST00000254079_ACLY_chr17_40055038_ENST00000393896_length(amino acids)=1000AA_BP=303
MGPEGEPGRGRDTRGEEERLREGGGEGRERQREETRRDTQEGRDTETQRHSGGERHRDAETPRPGSARERGTDLAQRARGASPESREPGG
APSPGADPPPAPAPSPRRARYFYPCANSPPPPLAAQPAACAGEPSTDRRRDPESRTPAPPPTPRAMDPKDRKKIQFSVPAPPSQLDPRQV
EMIRRRRPTPAMLFRLSEHSSPEEEASPHQRASGEGHHLKSKRPNPCAYTPPSLKAVQRIAESHLQSISNLNENQASEEEDELGELRELG
YPREEDEEEEEDDEEEEEEEDSQAEVLKVIRQSGKTTGIPIHVFGTETHMTAIVGMALGHRPIPNQPPTAAHTANFLLNASGSTSTPAPS
RTASFSESRADEVAPAKKAKPAMPQGKSTTLFSRHTKAIVWGMQTRAVQGMLDFDYVCSRDEPSVAAMVYPFTGDHKQKFYWGHKEILIP
VFKNMADAMRKHPEVDVLINFASLRSAYDSTMETMNYAQIRTIAIIAEGIPEALTRKLIKKADQKGVTIIGPATVGGIKPGCFKIGNTGG
MLDNILASKLYRPGSVAYVSRSGGMSNELNNIISRTTDGVYEGVAIGGDRYPGSTFMDHVLRYQDTPGVKMIVVLGEIGGTEEYKICRGI
KEGRLTKPIVCWCIGTCATMFSSEVQFGHAGACANQASETAVAKNQALKEAGVFVPRSFDELGEIIQSVYEDLVANGVIVPAQEVPPPTV
PMDYSWARELGLIRKPASFMTSICDERGQELIYAGMPITEVFKEEMGIGGVLGLLWFQKRLPKYSCQFIEMCLMVTADHGPAVSGAHNTI
ICARAGKDLVSSLTSGLLTIGDRFGGALDAAAKMFSKAFDSGIIPMEFVNKMKKEGKLIMGIGHRVKSINNPDMRVQILKDYVRQHFPAT
PLLDYALEVEKITTSKKPNLILNVDGLIGVAFVDMLRNCGSFTREEADEYIDIGALNGIFVLGRSMGFIGHYLDQKRLKQGLYRHPWDDI

--------------------------------------------------------------

>67863_67863_4_PPP1R1B-ACLY_PPP1R1B_chr17_37790339_ENST00000254079_ACLY_chr17_40055038_ENST00000537919_length(amino acids)=1000AA_BP=303
MGPEGEPGRGRDTRGEEERLREGGGEGRERQREETRRDTQEGRDTETQRHSGGERHRDAETPRPGSARERGTDLAQRARGASPESREPGG
APSPGADPPPAPAPSPRRARYFYPCANSPPPPLAAQPAACAGEPSTDRRRDPESRTPAPPPTPRAMDPKDRKKIQFSVPAPPSQLDPRQV
EMIRRRRPTPAMLFRLSEHSSPEEEASPHQRASGEGHHLKSKRPNPCAYTPPSLKAVQRIAESHLQSISNLNENQASEEEDELGELRELG
YPREEDEEEEEDDEEEEEEEDSQAEVLKVIRQSGKTTGIPIHVFGTETHMTAIVGMALGHRPIPNQPPTAAHTANFLLNASGSTSTPAPS
RTASFSESRADEVAPAKKAKPAMPQGKSTTLFSRHTKAIVWGMQTRAVQGMLDFDYVCSRDEPSVAAMVYPFTGDHKQKFYWGHKEILIP
VFKNMADAMRKHPEVDVLINFASLRSAYDSTMETMNYAQIRTIAIIAEGIPEALTRKLIKKADQKGVTIIGPATVGGIKPGCFKIGNTGG
MLDNILASKLYRPGSVAYVSRSGGMSNELNNIISRTTDGVYEGVAIGGDRYPGSTFMDHVLRYQDTPGVKMIVVLGEIGGTEEYKICRGI
KEGRLTKPIVCWCIGTCATMFSSEVQFGHAGACANQASETAVAKNQALKEAGVFVPRSFDELGEIIQSVYEDLVANGVIVPAQEVPPPTV
PMDYSWARELGLIRKPASFMTSICDERGQELIYAGMPITEVFKEEMGIGGVLGLLWFQKRLPKYSCQFIEMCLMVTADHGPAVSGAHNTI
ICARAGKDLVSSLTSGLLTIGDRFGGALDAAAKMFSKAFDSGIIPMEFVNKMKKEGKLIMGIGHRVKSINNPDMRVQILKDYVRQHFPAT
PLLDYALEVEKITTSKKPNLILNVDGLIGVAFVDMLRNCGSFTREEADEYIDIGALNGIFVLGRSMGFIGHYLDQKRLKQGLYRHPWDDI

--------------------------------------------------------------

>67863_67863_5_PPP1R1B-ACLY_PPP1R1B_chr17_37790339_ENST00000254079_ACLY_chr17_40055038_ENST00000590151_length(amino acids)=1010AA_BP=303
MGPEGEPGRGRDTRGEEERLREGGGEGRERQREETRRDTQEGRDTETQRHSGGERHRDAETPRPGSARERGTDLAQRARGASPESREPGG
APSPGADPPPAPAPSPRRARYFYPCANSPPPPLAAQPAACAGEPSTDRRRDPESRTPAPPPTPRAMDPKDRKKIQFSVPAPPSQLDPRQV
EMIRRRRPTPAMLFRLSEHSSPEEEASPHQRASGEGHHLKSKRPNPCAYTPPSLKAVQRIAESHLQSISNLNENQASEEEDELGELRELG
YPREEDEEEEEDDEEEEEEEDSQAEVLKVIRQSGKTTGIPIHVFGTETHMTAIVGMALGHRPIPNQPPTAAHTANFLLNASGSTSTPAPS
RTASFSESRADEVAPAKKAKPAMPQDSVPSPRSLQGKSTTLFSRHTKAIVWGMQTRAVQGMLDFDYVCSRDEPSVAAMVYPFTGDHKQKF
YWGHKEILIPVFKNMADAMRKHPEVDVLINFASLRSAYDSTMETMNYAQIRTIAIIAEGIPEALTRKLIKKADQKGVTIIGPATVGGIKP
GCFKIGNTGGMLDNILASKLYRPGSVAYVSRSGGMSNELNNIISRTTDGVYEGVAIGGDRYPGSTFMDHVLRYQDTPGVKMIVVLGEIGG
TEEYKICRGIKEGRLTKPIVCWCIGTCATMFSSEVQFGHAGACANQASETAVAKNQALKEAGVFVPRSFDELGEIIQSVYEDLVANGVIV
PAQEVPPPTVPMDYSWARELGLIRKPASFMTSICDERGQELIYAGMPITEVFKEEMGIGGVLGLLWFQKRLPKYSCQFIEMCLMVTADHG
PAVSGAHNTIICARAGKDLVSSLTSGLLTIGDRFGGALDAAAKMFSKAFDSGIIPMEFVNKMKKEGKLIMGIGHRVKSINNPDMRVQILK
DYVRQHFPATPLLDYALEVEKITTSKKPNLILNVDGLIGVAFVDMLRNCGSFTREEADEYIDIGALNGIFVLGRSMGFIGHYLDQKRLKQ

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>67863_67863_6_PPP1R1B-ACLY_PPP1R1B_chr17_37790339_ENST00000394265_ACLY_chr17_40055038_ENST00000352035_length(amino acids)=853AA_BP=146
MEKKPKPRPPERSPRPLWVPEPQLEIRRRRPTPAMLFRLSEHSSPEEEASPHQRASGEGHHLKSKRPNPCAYTPPSLKAVQRIAESHLQS
ISNLNENQASEEEDELGELRELGYPREEDEEEEEDDEEEEEEEDSQAEVLKVIRQSGKTTGIPIHVFGTETHMTAIVGMALGHRPIPNQP
PTAAHTANFLLNASGSTSTPAPSRTASFSESRADEVAPAKKAKPAMPQDSVPSPRSLQGKSTTLFSRHTKAIVWGMQTRAVQGMLDFDYV
CSRDEPSVAAMVYPFTGDHKQKFYWGHKEILIPVFKNMADAMRKHPEVDVLINFASLRSAYDSTMETMNYAQIRTIAIIAEGIPEALTRK
LIKKADQKGVTIIGPATVGGIKPGCFKIGNTGGMLDNILASKLYRPGSVAYVSRSGGMSNELNNIISRTTDGVYEGVAIGGDRYPGSTFM
DHVLRYQDTPGVKMIVVLGEIGGTEEYKICRGIKEGRLTKPIVCWCIGTCATMFSSEVQFGHAGACANQASETAVAKNQALKEAGVFVPR
SFDELGEIIQSVYEDLVANGVIVPAQEVPPPTVPMDYSWARELGLIRKPASFMTSICDERGQELIYAGMPITEVFKEEMGIGGVLGLLWF
QKRLPKYSCQFIEMCLMVTADHGPAVSGAHNTIICARAGKDLVSSLTSGLLTIGDRFGGALDAAAKMFSKAFDSGIIPMEFVNKMKKEGK
LIMGIGHRVKSINNPDMRVQILKDYVRQHFPATPLLDYALEVEKITTSKKPNLILNVDGLIGVAFVDMLRNCGSFTREEADEYIDIGALN

--------------------------------------------------------------

>67863_67863_7_PPP1R1B-ACLY_PPP1R1B_chr17_37790339_ENST00000394265_ACLY_chr17_40055038_ENST00000353196_length(amino acids)=843AA_BP=146
MEKKPKPRPPERSPRPLWVPEPQLEIRRRRPTPAMLFRLSEHSSPEEEASPHQRASGEGHHLKSKRPNPCAYTPPSLKAVQRIAESHLQS
ISNLNENQASEEEDELGELRELGYPREEDEEEEEDDEEEEEEEDSQAEVLKVIRQSGKTTGIPIHVFGTETHMTAIVGMALGHRPIPNQP
PTAAHTANFLLNASGSTSTPAPSRTASFSESRADEVAPAKKAKPAMPQGKSTTLFSRHTKAIVWGMQTRAVQGMLDFDYVCSRDEPSVAA
MVYPFTGDHKQKFYWGHKEILIPVFKNMADAMRKHPEVDVLINFASLRSAYDSTMETMNYAQIRTIAIIAEGIPEALTRKLIKKADQKGV
TIIGPATVGGIKPGCFKIGNTGGMLDNILASKLYRPGSVAYVSRSGGMSNELNNIISRTTDGVYEGVAIGGDRYPGSTFMDHVLRYQDTP
GVKMIVVLGEIGGTEEYKICRGIKEGRLTKPIVCWCIGTCATMFSSEVQFGHAGACANQASETAVAKNQALKEAGVFVPRSFDELGEIIQ
SVYEDLVANGVIVPAQEVPPPTVPMDYSWARELGLIRKPASFMTSICDERGQELIYAGMPITEVFKEEMGIGGVLGLLWFQKRLPKYSCQ
FIEMCLMVTADHGPAVSGAHNTIICARAGKDLVSSLTSGLLTIGDRFGGALDAAAKMFSKAFDSGIIPMEFVNKMKKEGKLIMGIGHRVK
SINNPDMRVQILKDYVRQHFPATPLLDYALEVEKITTSKKPNLILNVDGLIGVAFVDMLRNCGSFTREEADEYIDIGALNGIFVLGRSMG

--------------------------------------------------------------

>67863_67863_8_PPP1R1B-ACLY_PPP1R1B_chr17_37790339_ENST00000394265_ACLY_chr17_40055038_ENST00000393896_length(amino acids)=843AA_BP=146
MEKKPKPRPPERSPRPLWVPEPQLEIRRRRPTPAMLFRLSEHSSPEEEASPHQRASGEGHHLKSKRPNPCAYTPPSLKAVQRIAESHLQS
ISNLNENQASEEEDELGELRELGYPREEDEEEEEDDEEEEEEEDSQAEVLKVIRQSGKTTGIPIHVFGTETHMTAIVGMALGHRPIPNQP
PTAAHTANFLLNASGSTSTPAPSRTASFSESRADEVAPAKKAKPAMPQGKSTTLFSRHTKAIVWGMQTRAVQGMLDFDYVCSRDEPSVAA
MVYPFTGDHKQKFYWGHKEILIPVFKNMADAMRKHPEVDVLINFASLRSAYDSTMETMNYAQIRTIAIIAEGIPEALTRKLIKKADQKGV
TIIGPATVGGIKPGCFKIGNTGGMLDNILASKLYRPGSVAYVSRSGGMSNELNNIISRTTDGVYEGVAIGGDRYPGSTFMDHVLRYQDTP
GVKMIVVLGEIGGTEEYKICRGIKEGRLTKPIVCWCIGTCATMFSSEVQFGHAGACANQASETAVAKNQALKEAGVFVPRSFDELGEIIQ
SVYEDLVANGVIVPAQEVPPPTVPMDYSWARELGLIRKPASFMTSICDERGQELIYAGMPITEVFKEEMGIGGVLGLLWFQKRLPKYSCQ
FIEMCLMVTADHGPAVSGAHNTIICARAGKDLVSSLTSGLLTIGDRFGGALDAAAKMFSKAFDSGIIPMEFVNKMKKEGKLIMGIGHRVK
SINNPDMRVQILKDYVRQHFPATPLLDYALEVEKITTSKKPNLILNVDGLIGVAFVDMLRNCGSFTREEADEYIDIGALNGIFVLGRSMG

--------------------------------------------------------------

>67863_67863_9_PPP1R1B-ACLY_PPP1R1B_chr17_37790339_ENST00000394265_ACLY_chr17_40055038_ENST00000537919_length(amino acids)=843AA_BP=146
MEKKPKPRPPERSPRPLWVPEPQLEIRRRRPTPAMLFRLSEHSSPEEEASPHQRASGEGHHLKSKRPNPCAYTPPSLKAVQRIAESHLQS
ISNLNENQASEEEDELGELRELGYPREEDEEEEEDDEEEEEEEDSQAEVLKVIRQSGKTTGIPIHVFGTETHMTAIVGMALGHRPIPNQP
PTAAHTANFLLNASGSTSTPAPSRTASFSESRADEVAPAKKAKPAMPQGKSTTLFSRHTKAIVWGMQTRAVQGMLDFDYVCSRDEPSVAA
MVYPFTGDHKQKFYWGHKEILIPVFKNMADAMRKHPEVDVLINFASLRSAYDSTMETMNYAQIRTIAIIAEGIPEALTRKLIKKADQKGV
TIIGPATVGGIKPGCFKIGNTGGMLDNILASKLYRPGSVAYVSRSGGMSNELNNIISRTTDGVYEGVAIGGDRYPGSTFMDHVLRYQDTP
GVKMIVVLGEIGGTEEYKICRGIKEGRLTKPIVCWCIGTCATMFSSEVQFGHAGACANQASETAVAKNQALKEAGVFVPRSFDELGEIIQ
SVYEDLVANGVIVPAQEVPPPTVPMDYSWARELGLIRKPASFMTSICDERGQELIYAGMPITEVFKEEMGIGGVLGLLWFQKRLPKYSCQ
FIEMCLMVTADHGPAVSGAHNTIICARAGKDLVSSLTSGLLTIGDRFGGALDAAAKMFSKAFDSGIIPMEFVNKMKKEGKLIMGIGHRVK
SINNPDMRVQILKDYVRQHFPATPLLDYALEVEKITTSKKPNLILNVDGLIGVAFVDMLRNCGSFTREEADEYIDIGALNGIFVLGRSMG

--------------------------------------------------------------

>67863_67863_10_PPP1R1B-ACLY_PPP1R1B_chr17_37790339_ENST00000394265_ACLY_chr17_40055038_ENST00000590151_length(amino acids)=853AA_BP=146
MEKKPKPRPPERSPRPLWVPEPQLEIRRRRPTPAMLFRLSEHSSPEEEASPHQRASGEGHHLKSKRPNPCAYTPPSLKAVQRIAESHLQS
ISNLNENQASEEEDELGELRELGYPREEDEEEEEDDEEEEEEEDSQAEVLKVIRQSGKTTGIPIHVFGTETHMTAIVGMALGHRPIPNQP
PTAAHTANFLLNASGSTSTPAPSRTASFSESRADEVAPAKKAKPAMPQDSVPSPRSLQGKSTTLFSRHTKAIVWGMQTRAVQGMLDFDYV
CSRDEPSVAAMVYPFTGDHKQKFYWGHKEILIPVFKNMADAMRKHPEVDVLINFASLRSAYDSTMETMNYAQIRTIAIIAEGIPEALTRK
LIKKADQKGVTIIGPATVGGIKPGCFKIGNTGGMLDNILASKLYRPGSVAYVSRSGGMSNELNNIISRTTDGVYEGVAIGGDRYPGSTFM
DHVLRYQDTPGVKMIVVLGEIGGTEEYKICRGIKEGRLTKPIVCWCIGTCATMFSSEVQFGHAGACANQASETAVAKNQALKEAGVFVPR
SFDELGEIIQSVYEDLVANGVIVPAQEVPPPTVPMDYSWARELGLIRKPASFMTSICDERGQELIYAGMPITEVFKEEMGIGGVLGLLWF
QKRLPKYSCQFIEMCLMVTADHGPAVSGAHNTIICARAGKDLVSSLTSGLLTIGDRFGGALDAAAKMFSKAFDSGIIPMEFVNKMKKEGK
LIMGIGHRVKSINNPDMRVQILKDYVRQHFPATPLLDYALEVEKITTSKKPNLILNVDGLIGVAFVDMLRNCGSFTREEADEYIDIGALN

--------------------------------------------------------------

>67863_67863_11_PPP1R1B-ACLY_PPP1R1B_chr17_37790339_ENST00000394267_ACLY_chr17_40055038_ENST00000352035_length(amino acids)=819AA_BP=112
MLFRLSEHSSPEEEASPHQRASGEGHHLKSKRPNPCAYTPPSLKAVQRIAESHLQSISNLNENQASEEEDELGELRELGYPREEDEEEEE
DDEEEEEEEDSQAEVLKVIRQSGKTTGIPIHVFGTETHMTAIVGMALGHRPIPNQPPTAAHTANFLLNASGSTSTPAPSRTASFSESRAD
EVAPAKKAKPAMPQDSVPSPRSLQGKSTTLFSRHTKAIVWGMQTRAVQGMLDFDYVCSRDEPSVAAMVYPFTGDHKQKFYWGHKEILIPV
FKNMADAMRKHPEVDVLINFASLRSAYDSTMETMNYAQIRTIAIIAEGIPEALTRKLIKKADQKGVTIIGPATVGGIKPGCFKIGNTGGM
LDNILASKLYRPGSVAYVSRSGGMSNELNNIISRTTDGVYEGVAIGGDRYPGSTFMDHVLRYQDTPGVKMIVVLGEIGGTEEYKICRGIK
EGRLTKPIVCWCIGTCATMFSSEVQFGHAGACANQASETAVAKNQALKEAGVFVPRSFDELGEIIQSVYEDLVANGVIVPAQEVPPPTVP
MDYSWARELGLIRKPASFMTSICDERGQELIYAGMPITEVFKEEMGIGGVLGLLWFQKRLPKYSCQFIEMCLMVTADHGPAVSGAHNTII
CARAGKDLVSSLTSGLLTIGDRFGGALDAAAKMFSKAFDSGIIPMEFVNKMKKEGKLIMGIGHRVKSINNPDMRVQILKDYVRQHFPATP
LLDYALEVEKITTSKKPNLILNVDGLIGVAFVDMLRNCGSFTREEADEYIDIGALNGIFVLGRSMGFIGHYLDQKRLKQGLYRHPWDDIS

--------------------------------------------------------------

>67863_67863_12_PPP1R1B-ACLY_PPP1R1B_chr17_37790339_ENST00000394267_ACLY_chr17_40055038_ENST00000353196_length(amino acids)=809AA_BP=112
MLFRLSEHSSPEEEASPHQRASGEGHHLKSKRPNPCAYTPPSLKAVQRIAESHLQSISNLNENQASEEEDELGELRELGYPREEDEEEEE
DDEEEEEEEDSQAEVLKVIRQSGKTTGIPIHVFGTETHMTAIVGMALGHRPIPNQPPTAAHTANFLLNASGSTSTPAPSRTASFSESRAD
EVAPAKKAKPAMPQGKSTTLFSRHTKAIVWGMQTRAVQGMLDFDYVCSRDEPSVAAMVYPFTGDHKQKFYWGHKEILIPVFKNMADAMRK
HPEVDVLINFASLRSAYDSTMETMNYAQIRTIAIIAEGIPEALTRKLIKKADQKGVTIIGPATVGGIKPGCFKIGNTGGMLDNILASKLY
RPGSVAYVSRSGGMSNELNNIISRTTDGVYEGVAIGGDRYPGSTFMDHVLRYQDTPGVKMIVVLGEIGGTEEYKICRGIKEGRLTKPIVC
WCIGTCATMFSSEVQFGHAGACANQASETAVAKNQALKEAGVFVPRSFDELGEIIQSVYEDLVANGVIVPAQEVPPPTVPMDYSWARELG
LIRKPASFMTSICDERGQELIYAGMPITEVFKEEMGIGGVLGLLWFQKRLPKYSCQFIEMCLMVTADHGPAVSGAHNTIICARAGKDLVS
SLTSGLLTIGDRFGGALDAAAKMFSKAFDSGIIPMEFVNKMKKEGKLIMGIGHRVKSINNPDMRVQILKDYVRQHFPATPLLDYALEVEK

--------------------------------------------------------------

>67863_67863_13_PPP1R1B-ACLY_PPP1R1B_chr17_37790339_ENST00000394267_ACLY_chr17_40055038_ENST00000393896_length(amino acids)=809AA_BP=112
MLFRLSEHSSPEEEASPHQRASGEGHHLKSKRPNPCAYTPPSLKAVQRIAESHLQSISNLNENQASEEEDELGELRELGYPREEDEEEEE
DDEEEEEEEDSQAEVLKVIRQSGKTTGIPIHVFGTETHMTAIVGMALGHRPIPNQPPTAAHTANFLLNASGSTSTPAPSRTASFSESRAD
EVAPAKKAKPAMPQGKSTTLFSRHTKAIVWGMQTRAVQGMLDFDYVCSRDEPSVAAMVYPFTGDHKQKFYWGHKEILIPVFKNMADAMRK
HPEVDVLINFASLRSAYDSTMETMNYAQIRTIAIIAEGIPEALTRKLIKKADQKGVTIIGPATVGGIKPGCFKIGNTGGMLDNILASKLY
RPGSVAYVSRSGGMSNELNNIISRTTDGVYEGVAIGGDRYPGSTFMDHVLRYQDTPGVKMIVVLGEIGGTEEYKICRGIKEGRLTKPIVC
WCIGTCATMFSSEVQFGHAGACANQASETAVAKNQALKEAGVFVPRSFDELGEIIQSVYEDLVANGVIVPAQEVPPPTVPMDYSWARELG
LIRKPASFMTSICDERGQELIYAGMPITEVFKEEMGIGGVLGLLWFQKRLPKYSCQFIEMCLMVTADHGPAVSGAHNTIICARAGKDLVS
SLTSGLLTIGDRFGGALDAAAKMFSKAFDSGIIPMEFVNKMKKEGKLIMGIGHRVKSINNPDMRVQILKDYVRQHFPATPLLDYALEVEK

--------------------------------------------------------------

>67863_67863_14_PPP1R1B-ACLY_PPP1R1B_chr17_37790339_ENST00000394267_ACLY_chr17_40055038_ENST00000537919_length(amino acids)=809AA_BP=112
MLFRLSEHSSPEEEASPHQRASGEGHHLKSKRPNPCAYTPPSLKAVQRIAESHLQSISNLNENQASEEEDELGELRELGYPREEDEEEEE
DDEEEEEEEDSQAEVLKVIRQSGKTTGIPIHVFGTETHMTAIVGMALGHRPIPNQPPTAAHTANFLLNASGSTSTPAPSRTASFSESRAD
EVAPAKKAKPAMPQGKSTTLFSRHTKAIVWGMQTRAVQGMLDFDYVCSRDEPSVAAMVYPFTGDHKQKFYWGHKEILIPVFKNMADAMRK
HPEVDVLINFASLRSAYDSTMETMNYAQIRTIAIIAEGIPEALTRKLIKKADQKGVTIIGPATVGGIKPGCFKIGNTGGMLDNILASKLY
RPGSVAYVSRSGGMSNELNNIISRTTDGVYEGVAIGGDRYPGSTFMDHVLRYQDTPGVKMIVVLGEIGGTEEYKICRGIKEGRLTKPIVC
WCIGTCATMFSSEVQFGHAGACANQASETAVAKNQALKEAGVFVPRSFDELGEIIQSVYEDLVANGVIVPAQEVPPPTVPMDYSWARELG
LIRKPASFMTSICDERGQELIYAGMPITEVFKEEMGIGGVLGLLWFQKRLPKYSCQFIEMCLMVTADHGPAVSGAHNTIICARAGKDLVS
SLTSGLLTIGDRFGGALDAAAKMFSKAFDSGIIPMEFVNKMKKEGKLIMGIGHRVKSINNPDMRVQILKDYVRQHFPATPLLDYALEVEK

--------------------------------------------------------------

>67863_67863_15_PPP1R1B-ACLY_PPP1R1B_chr17_37790339_ENST00000394267_ACLY_chr17_40055038_ENST00000590151_length(amino acids)=819AA_BP=112
MLFRLSEHSSPEEEASPHQRASGEGHHLKSKRPNPCAYTPPSLKAVQRIAESHLQSISNLNENQASEEEDELGELRELGYPREEDEEEEE
DDEEEEEEEDSQAEVLKVIRQSGKTTGIPIHVFGTETHMTAIVGMALGHRPIPNQPPTAAHTANFLLNASGSTSTPAPSRTASFSESRAD
EVAPAKKAKPAMPQDSVPSPRSLQGKSTTLFSRHTKAIVWGMQTRAVQGMLDFDYVCSRDEPSVAAMVYPFTGDHKQKFYWGHKEILIPV
FKNMADAMRKHPEVDVLINFASLRSAYDSTMETMNYAQIRTIAIIAEGIPEALTRKLIKKADQKGVTIIGPATVGGIKPGCFKIGNTGGM
LDNILASKLYRPGSVAYVSRSGGMSNELNNIISRTTDGVYEGVAIGGDRYPGSTFMDHVLRYQDTPGVKMIVVLGEIGGTEEYKICRGIK
EGRLTKPIVCWCIGTCATMFSSEVQFGHAGACANQASETAVAKNQALKEAGVFVPRSFDELGEIIQSVYEDLVANGVIVPAQEVPPPTVP
MDYSWARELGLIRKPASFMTSICDERGQELIYAGMPITEVFKEEMGIGGVLGLLWFQKRLPKYSCQFIEMCLMVTADHGPAVSGAHNTII
CARAGKDLVSSLTSGLLTIGDRFGGALDAAAKMFSKAFDSGIIPMEFVNKMKKEGKLIMGIGHRVKSINNPDMRVQILKDYVRQHFPATP
LLDYALEVEKITTSKKPNLILNVDGLIGVAFVDMLRNCGSFTREEADEYIDIGALNGIFVLGRSMGFIGHYLDQKRLKQGLYRHPWDDIS

--------------------------------------------------------------

>67863_67863_16_PPP1R1B-ACLY_PPP1R1B_chr17_37790339_ENST00000579000_ACLY_chr17_40055038_ENST00000352035_length(amino acids)=822AA_BP=115
MDPKDRKKIQFSVPAPPSQLDPRQVEMIRRRRPTPAMLFRLSEHSSPAVQRIAESHLQSISNLNENQASEEEDELGELRELGYPREEDEE
EEEDDEEEEEEEDSQAEVLKVIRQSGKTTGIPIHVFGTETHMTAIVGMALGHRPIPNQPPTAAHTANFLLNASGSTSTPAPSRTASFSES
RADEVAPAKKAKPAMPQDSVPSPRSLQGKSTTLFSRHTKAIVWGMQTRAVQGMLDFDYVCSRDEPSVAAMVYPFTGDHKQKFYWGHKEIL
IPVFKNMADAMRKHPEVDVLINFASLRSAYDSTMETMNYAQIRTIAIIAEGIPEALTRKLIKKADQKGVTIIGPATVGGIKPGCFKIGNT
GGMLDNILASKLYRPGSVAYVSRSGGMSNELNNIISRTTDGVYEGVAIGGDRYPGSTFMDHVLRYQDTPGVKMIVVLGEIGGTEEYKICR
GIKEGRLTKPIVCWCIGTCATMFSSEVQFGHAGACANQASETAVAKNQALKEAGVFVPRSFDELGEIIQSVYEDLVANGVIVPAQEVPPP
TVPMDYSWARELGLIRKPASFMTSICDERGQELIYAGMPITEVFKEEMGIGGVLGLLWFQKRLPKYSCQFIEMCLMVTADHGPAVSGAHN
TIICARAGKDLVSSLTSGLLTIGDRFGGALDAAAKMFSKAFDSGIIPMEFVNKMKKEGKLIMGIGHRVKSINNPDMRVQILKDYVRQHFP
ATPLLDYALEVEKITTSKKPNLILNVDGLIGVAFVDMLRNCGSFTREEADEYIDIGALNGIFVLGRSMGFIGHYLDQKRLKQGLYRHPWD

--------------------------------------------------------------

>67863_67863_17_PPP1R1B-ACLY_PPP1R1B_chr17_37790339_ENST00000579000_ACLY_chr17_40055038_ENST00000353196_length(amino acids)=812AA_BP=115
MDPKDRKKIQFSVPAPPSQLDPRQVEMIRRRRPTPAMLFRLSEHSSPAVQRIAESHLQSISNLNENQASEEEDELGELRELGYPREEDEE
EEEDDEEEEEEEDSQAEVLKVIRQSGKTTGIPIHVFGTETHMTAIVGMALGHRPIPNQPPTAAHTANFLLNASGSTSTPAPSRTASFSES
RADEVAPAKKAKPAMPQGKSTTLFSRHTKAIVWGMQTRAVQGMLDFDYVCSRDEPSVAAMVYPFTGDHKQKFYWGHKEILIPVFKNMADA
MRKHPEVDVLINFASLRSAYDSTMETMNYAQIRTIAIIAEGIPEALTRKLIKKADQKGVTIIGPATVGGIKPGCFKIGNTGGMLDNILAS
KLYRPGSVAYVSRSGGMSNELNNIISRTTDGVYEGVAIGGDRYPGSTFMDHVLRYQDTPGVKMIVVLGEIGGTEEYKICRGIKEGRLTKP
IVCWCIGTCATMFSSEVQFGHAGACANQASETAVAKNQALKEAGVFVPRSFDELGEIIQSVYEDLVANGVIVPAQEVPPPTVPMDYSWAR
ELGLIRKPASFMTSICDERGQELIYAGMPITEVFKEEMGIGGVLGLLWFQKRLPKYSCQFIEMCLMVTADHGPAVSGAHNTIICARAGKD
LVSSLTSGLLTIGDRFGGALDAAAKMFSKAFDSGIIPMEFVNKMKKEGKLIMGIGHRVKSINNPDMRVQILKDYVRQHFPATPLLDYALE
VEKITTSKKPNLILNVDGLIGVAFVDMLRNCGSFTREEADEYIDIGALNGIFVLGRSMGFIGHYLDQKRLKQGLYRHPWDDISYVLPEHM

--------------------------------------------------------------

>67863_67863_18_PPP1R1B-ACLY_PPP1R1B_chr17_37790339_ENST00000579000_ACLY_chr17_40055038_ENST00000393896_length(amino acids)=812AA_BP=115
MDPKDRKKIQFSVPAPPSQLDPRQVEMIRRRRPTPAMLFRLSEHSSPAVQRIAESHLQSISNLNENQASEEEDELGELRELGYPREEDEE
EEEDDEEEEEEEDSQAEVLKVIRQSGKTTGIPIHVFGTETHMTAIVGMALGHRPIPNQPPTAAHTANFLLNASGSTSTPAPSRTASFSES
RADEVAPAKKAKPAMPQGKSTTLFSRHTKAIVWGMQTRAVQGMLDFDYVCSRDEPSVAAMVYPFTGDHKQKFYWGHKEILIPVFKNMADA
MRKHPEVDVLINFASLRSAYDSTMETMNYAQIRTIAIIAEGIPEALTRKLIKKADQKGVTIIGPATVGGIKPGCFKIGNTGGMLDNILAS
KLYRPGSVAYVSRSGGMSNELNNIISRTTDGVYEGVAIGGDRYPGSTFMDHVLRYQDTPGVKMIVVLGEIGGTEEYKICRGIKEGRLTKP
IVCWCIGTCATMFSSEVQFGHAGACANQASETAVAKNQALKEAGVFVPRSFDELGEIIQSVYEDLVANGVIVPAQEVPPPTVPMDYSWAR
ELGLIRKPASFMTSICDERGQELIYAGMPITEVFKEEMGIGGVLGLLWFQKRLPKYSCQFIEMCLMVTADHGPAVSGAHNTIICARAGKD
LVSSLTSGLLTIGDRFGGALDAAAKMFSKAFDSGIIPMEFVNKMKKEGKLIMGIGHRVKSINNPDMRVQILKDYVRQHFPATPLLDYALE
VEKITTSKKPNLILNVDGLIGVAFVDMLRNCGSFTREEADEYIDIGALNGIFVLGRSMGFIGHYLDQKRLKQGLYRHPWDDISYVLPEHM

--------------------------------------------------------------

>67863_67863_19_PPP1R1B-ACLY_PPP1R1B_chr17_37790339_ENST00000579000_ACLY_chr17_40055038_ENST00000537919_length(amino acids)=812AA_BP=115
MDPKDRKKIQFSVPAPPSQLDPRQVEMIRRRRPTPAMLFRLSEHSSPAVQRIAESHLQSISNLNENQASEEEDELGELRELGYPREEDEE
EEEDDEEEEEEEDSQAEVLKVIRQSGKTTGIPIHVFGTETHMTAIVGMALGHRPIPNQPPTAAHTANFLLNASGSTSTPAPSRTASFSES
RADEVAPAKKAKPAMPQGKSTTLFSRHTKAIVWGMQTRAVQGMLDFDYVCSRDEPSVAAMVYPFTGDHKQKFYWGHKEILIPVFKNMADA
MRKHPEVDVLINFASLRSAYDSTMETMNYAQIRTIAIIAEGIPEALTRKLIKKADQKGVTIIGPATVGGIKPGCFKIGNTGGMLDNILAS
KLYRPGSVAYVSRSGGMSNELNNIISRTTDGVYEGVAIGGDRYPGSTFMDHVLRYQDTPGVKMIVVLGEIGGTEEYKICRGIKEGRLTKP
IVCWCIGTCATMFSSEVQFGHAGACANQASETAVAKNQALKEAGVFVPRSFDELGEIIQSVYEDLVANGVIVPAQEVPPPTVPMDYSWAR
ELGLIRKPASFMTSICDERGQELIYAGMPITEVFKEEMGIGGVLGLLWFQKRLPKYSCQFIEMCLMVTADHGPAVSGAHNTIICARAGKD
LVSSLTSGLLTIGDRFGGALDAAAKMFSKAFDSGIIPMEFVNKMKKEGKLIMGIGHRVKSINNPDMRVQILKDYVRQHFPATPLLDYALE
VEKITTSKKPNLILNVDGLIGVAFVDMLRNCGSFTREEADEYIDIGALNGIFVLGRSMGFIGHYLDQKRLKQGLYRHPWDDISYVLPEHM

--------------------------------------------------------------

>67863_67863_20_PPP1R1B-ACLY_PPP1R1B_chr17_37790339_ENST00000579000_ACLY_chr17_40055038_ENST00000590151_length(amino acids)=822AA_BP=115
MDPKDRKKIQFSVPAPPSQLDPRQVEMIRRRRPTPAMLFRLSEHSSPAVQRIAESHLQSISNLNENQASEEEDELGELRELGYPREEDEE
EEEDDEEEEEEEDSQAEVLKVIRQSGKTTGIPIHVFGTETHMTAIVGMALGHRPIPNQPPTAAHTANFLLNASGSTSTPAPSRTASFSES
RADEVAPAKKAKPAMPQDSVPSPRSLQGKSTTLFSRHTKAIVWGMQTRAVQGMLDFDYVCSRDEPSVAAMVYPFTGDHKQKFYWGHKEIL
IPVFKNMADAMRKHPEVDVLINFASLRSAYDSTMETMNYAQIRTIAIIAEGIPEALTRKLIKKADQKGVTIIGPATVGGIKPGCFKIGNT
GGMLDNILASKLYRPGSVAYVSRSGGMSNELNNIISRTTDGVYEGVAIGGDRYPGSTFMDHVLRYQDTPGVKMIVVLGEIGGTEEYKICR
GIKEGRLTKPIVCWCIGTCATMFSSEVQFGHAGACANQASETAVAKNQALKEAGVFVPRSFDELGEIIQSVYEDLVANGVIVPAQEVPPP
TVPMDYSWARELGLIRKPASFMTSICDERGQELIYAGMPITEVFKEEMGIGGVLGLLWFQKRLPKYSCQFIEMCLMVTADHGPAVSGAHN
TIICARAGKDLVSSLTSGLLTIGDRFGGALDAAAKMFSKAFDSGIIPMEFVNKMKKEGKLIMGIGHRVKSINNPDMRVQILKDYVRQHFP
ATPLLDYALEVEKITTSKKPNLILNVDGLIGVAFVDMLRNCGSFTREEADEYIDIGALNGIFVLGRSMGFIGHYLDQKRLKQGLYRHPWD

--------------------------------------------------------------

>67863_67863_21_PPP1R1B-ACLY_PPP1R1B_chr17_37790339_ENST00000580825_ACLY_chr17_40055038_ENST00000352035_length(amino acids)=855AA_BP=148
MDPKDRKKIQFSVPAPPSQLDPRQVEMIRRRRPTPAMLFRLSEHSSPEEEASPHQRASGEGHHLKSKRPNPCAYTPPSLKAVQRIAESHL
QSISNLNENQASEEEDELGELRELGYPREEDEEEEEDDEEEEEEEDSQAEVLKVIRQSGKTTGIPIHVFGTETHMTAIVGMALGHRPIPN
QPPTAAHTANFLLNASGSTSTPAPSRTASFSESRADEVAPAKKAKPAMPQDSVPSPRSLQGKSTTLFSRHTKAIVWGMQTRAVQGMLDFD
YVCSRDEPSVAAMVYPFTGDHKQKFYWGHKEILIPVFKNMADAMRKHPEVDVLINFASLRSAYDSTMETMNYAQIRTIAIIAEGIPEALT
RKLIKKADQKGVTIIGPATVGGIKPGCFKIGNTGGMLDNILASKLYRPGSVAYVSRSGGMSNELNNIISRTTDGVYEGVAIGGDRYPGST
FMDHVLRYQDTPGVKMIVVLGEIGGTEEYKICRGIKEGRLTKPIVCWCIGTCATMFSSEVQFGHAGACANQASETAVAKNQALKEAGVFV
PRSFDELGEIIQSVYEDLVANGVIVPAQEVPPPTVPMDYSWARELGLIRKPASFMTSICDERGQELIYAGMPITEVFKEEMGIGGVLGLL
WFQKRLPKYSCQFIEMCLMVTADHGPAVSGAHNTIICARAGKDLVSSLTSGLLTIGDRFGGALDAAAKMFSKAFDSGIIPMEFVNKMKKE
GKLIMGIGHRVKSINNPDMRVQILKDYVRQHFPATPLLDYALEVEKITTSKKPNLILNVDGLIGVAFVDMLRNCGSFTREEADEYIDIGA

--------------------------------------------------------------

>67863_67863_22_PPP1R1B-ACLY_PPP1R1B_chr17_37790339_ENST00000580825_ACLY_chr17_40055038_ENST00000353196_length(amino acids)=845AA_BP=148
MDPKDRKKIQFSVPAPPSQLDPRQVEMIRRRRPTPAMLFRLSEHSSPEEEASPHQRASGEGHHLKSKRPNPCAYTPPSLKAVQRIAESHL
QSISNLNENQASEEEDELGELRELGYPREEDEEEEEDDEEEEEEEDSQAEVLKVIRQSGKTTGIPIHVFGTETHMTAIVGMALGHRPIPN
QPPTAAHTANFLLNASGSTSTPAPSRTASFSESRADEVAPAKKAKPAMPQGKSTTLFSRHTKAIVWGMQTRAVQGMLDFDYVCSRDEPSV
AAMVYPFTGDHKQKFYWGHKEILIPVFKNMADAMRKHPEVDVLINFASLRSAYDSTMETMNYAQIRTIAIIAEGIPEALTRKLIKKADQK
GVTIIGPATVGGIKPGCFKIGNTGGMLDNILASKLYRPGSVAYVSRSGGMSNELNNIISRTTDGVYEGVAIGGDRYPGSTFMDHVLRYQD
TPGVKMIVVLGEIGGTEEYKICRGIKEGRLTKPIVCWCIGTCATMFSSEVQFGHAGACANQASETAVAKNQALKEAGVFVPRSFDELGEI
IQSVYEDLVANGVIVPAQEVPPPTVPMDYSWARELGLIRKPASFMTSICDERGQELIYAGMPITEVFKEEMGIGGVLGLLWFQKRLPKYS
CQFIEMCLMVTADHGPAVSGAHNTIICARAGKDLVSSLTSGLLTIGDRFGGALDAAAKMFSKAFDSGIIPMEFVNKMKKEGKLIMGIGHR
VKSINNPDMRVQILKDYVRQHFPATPLLDYALEVEKITTSKKPNLILNVDGLIGVAFVDMLRNCGSFTREEADEYIDIGALNGIFVLGRS

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>67863_67863_23_PPP1R1B-ACLY_PPP1R1B_chr17_37790339_ENST00000580825_ACLY_chr17_40055038_ENST00000393896_length(amino acids)=845AA_BP=148
MDPKDRKKIQFSVPAPPSQLDPRQVEMIRRRRPTPAMLFRLSEHSSPEEEASPHQRASGEGHHLKSKRPNPCAYTPPSLKAVQRIAESHL
QSISNLNENQASEEEDELGELRELGYPREEDEEEEEDDEEEEEEEDSQAEVLKVIRQSGKTTGIPIHVFGTETHMTAIVGMALGHRPIPN
QPPTAAHTANFLLNASGSTSTPAPSRTASFSESRADEVAPAKKAKPAMPQGKSTTLFSRHTKAIVWGMQTRAVQGMLDFDYVCSRDEPSV
AAMVYPFTGDHKQKFYWGHKEILIPVFKNMADAMRKHPEVDVLINFASLRSAYDSTMETMNYAQIRTIAIIAEGIPEALTRKLIKKADQK
GVTIIGPATVGGIKPGCFKIGNTGGMLDNILASKLYRPGSVAYVSRSGGMSNELNNIISRTTDGVYEGVAIGGDRYPGSTFMDHVLRYQD
TPGVKMIVVLGEIGGTEEYKICRGIKEGRLTKPIVCWCIGTCATMFSSEVQFGHAGACANQASETAVAKNQALKEAGVFVPRSFDELGEI
IQSVYEDLVANGVIVPAQEVPPPTVPMDYSWARELGLIRKPASFMTSICDERGQELIYAGMPITEVFKEEMGIGGVLGLLWFQKRLPKYS
CQFIEMCLMVTADHGPAVSGAHNTIICARAGKDLVSSLTSGLLTIGDRFGGALDAAAKMFSKAFDSGIIPMEFVNKMKKEGKLIMGIGHR
VKSINNPDMRVQILKDYVRQHFPATPLLDYALEVEKITTSKKPNLILNVDGLIGVAFVDMLRNCGSFTREEADEYIDIGALNGIFVLGRS

--------------------------------------------------------------

>67863_67863_24_PPP1R1B-ACLY_PPP1R1B_chr17_37790339_ENST00000580825_ACLY_chr17_40055038_ENST00000537919_length(amino acids)=845AA_BP=148
MDPKDRKKIQFSVPAPPSQLDPRQVEMIRRRRPTPAMLFRLSEHSSPEEEASPHQRASGEGHHLKSKRPNPCAYTPPSLKAVQRIAESHL
QSISNLNENQASEEEDELGELRELGYPREEDEEEEEDDEEEEEEEDSQAEVLKVIRQSGKTTGIPIHVFGTETHMTAIVGMALGHRPIPN
QPPTAAHTANFLLNASGSTSTPAPSRTASFSESRADEVAPAKKAKPAMPQGKSTTLFSRHTKAIVWGMQTRAVQGMLDFDYVCSRDEPSV
AAMVYPFTGDHKQKFYWGHKEILIPVFKNMADAMRKHPEVDVLINFASLRSAYDSTMETMNYAQIRTIAIIAEGIPEALTRKLIKKADQK
GVTIIGPATVGGIKPGCFKIGNTGGMLDNILASKLYRPGSVAYVSRSGGMSNELNNIISRTTDGVYEGVAIGGDRYPGSTFMDHVLRYQD
TPGVKMIVVLGEIGGTEEYKICRGIKEGRLTKPIVCWCIGTCATMFSSEVQFGHAGACANQASETAVAKNQALKEAGVFVPRSFDELGEI
IQSVYEDLVANGVIVPAQEVPPPTVPMDYSWARELGLIRKPASFMTSICDERGQELIYAGMPITEVFKEEMGIGGVLGLLWFQKRLPKYS
CQFIEMCLMVTADHGPAVSGAHNTIICARAGKDLVSSLTSGLLTIGDRFGGALDAAAKMFSKAFDSGIIPMEFVNKMKKEGKLIMGIGHR
VKSINNPDMRVQILKDYVRQHFPATPLLDYALEVEKITTSKKPNLILNVDGLIGVAFVDMLRNCGSFTREEADEYIDIGALNGIFVLGRS

--------------------------------------------------------------

>67863_67863_25_PPP1R1B-ACLY_PPP1R1B_chr17_37790339_ENST00000580825_ACLY_chr17_40055038_ENST00000590151_length(amino acids)=855AA_BP=148
MDPKDRKKIQFSVPAPPSQLDPRQVEMIRRRRPTPAMLFRLSEHSSPEEEASPHQRASGEGHHLKSKRPNPCAYTPPSLKAVQRIAESHL
QSISNLNENQASEEEDELGELRELGYPREEDEEEEEDDEEEEEEEDSQAEVLKVIRQSGKTTGIPIHVFGTETHMTAIVGMALGHRPIPN
QPPTAAHTANFLLNASGSTSTPAPSRTASFSESRADEVAPAKKAKPAMPQDSVPSPRSLQGKSTTLFSRHTKAIVWGMQTRAVQGMLDFD
YVCSRDEPSVAAMVYPFTGDHKQKFYWGHKEILIPVFKNMADAMRKHPEVDVLINFASLRSAYDSTMETMNYAQIRTIAIIAEGIPEALT
RKLIKKADQKGVTIIGPATVGGIKPGCFKIGNTGGMLDNILASKLYRPGSVAYVSRSGGMSNELNNIISRTTDGVYEGVAIGGDRYPGST
FMDHVLRYQDTPGVKMIVVLGEIGGTEEYKICRGIKEGRLTKPIVCWCIGTCATMFSSEVQFGHAGACANQASETAVAKNQALKEAGVFV
PRSFDELGEIIQSVYEDLVANGVIVPAQEVPPPTVPMDYSWARELGLIRKPASFMTSICDERGQELIYAGMPITEVFKEEMGIGGVLGLL
WFQKRLPKYSCQFIEMCLMVTADHGPAVSGAHNTIICARAGKDLVSSLTSGLLTIGDRFGGALDAAAKMFSKAFDSGIIPMEFVNKMKKE
GKLIMGIGHRVKSINNPDMRVQILKDYVRQHFPATPLLDYALEVEKITTSKKPNLILNVDGLIGVAFVDMLRNCGSFTREEADEYIDIGA

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr17:37790339/chr17:40058066)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.ACLY

P53396

FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Catalyzes the cleavage of citrate into oxaloacetate and acetyl-CoA, the latter serving as common substrate for de novo cholesterol and fatty acid synthesis. {ECO:0000269|PubMed:10653665, ECO:0000269|PubMed:1371749, ECO:0000269|PubMed:19286649, ECO:0000269|PubMed:23932781, ECO:0000269|PubMed:9116495}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePPP1R1Bchr17:37790339chr17:40055038ENST00000254079+57119_136148.33333333333334205.0Compositional biasNote=Asp/Glu-rich (acidic)
HgenePPP1R1Bchr17:37790339chr17:40055038ENST00000580825+68119_136148.33333333333334205.0Compositional biasNote=Asp/Glu-rich (acidic)
TgeneACLYchr17:37790339chr17:40055038ENST000003520351029701_721394.33333333333331102.0Nucleotide bindingATP
TgeneACLYchr17:37790339chr17:40055038ENST000003520351029752_778394.33333333333331102.0Nucleotide bindingATP
TgeneACLYchr17:37790339chr17:40055038ENST000003531961028701_721394.33333333333331092.0Nucleotide bindingATP
TgeneACLYchr17:37790339chr17:40055038ENST000003531961028752_778394.33333333333331092.0Nucleotide bindingATP
TgeneACLYchr17:37790339chr17:40055038ENST000003938961028701_721394.33333333333331092.0Nucleotide bindingATP
TgeneACLYchr17:37790339chr17:40055038ENST000003938961028752_778394.33333333333331092.0Nucleotide bindingATP
TgeneACLYchr17:37790339chr17:40055038ENST000005901511029701_721394.33333333333331102.0Nucleotide bindingATP
TgeneACLYchr17:37790339chr17:40055038ENST000005901511029752_778394.33333333333331102.0Nucleotide bindingATP
TgeneACLYchr17:37790339chr17:40055038ENST000003520351029779_789394.33333333333331102.0RegionCoA-binding
TgeneACLYchr17:37790339chr17:40055038ENST000003531961028779_789394.33333333333331092.0RegionCoA-binding
TgeneACLYchr17:37790339chr17:40055038ENST000003938961028779_789394.33333333333331092.0RegionCoA-binding
TgeneACLYchr17:37790339chr17:40055038ENST000005901511029779_789394.33333333333331102.0RegionCoA-binding

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePPP1R1Bchr17:37790339chr17:40055038ENST00000394265+57119_136112.33333333333333169.0Compositional biasNote=Asp/Glu-rich (acidic)
HgenePPP1R1Bchr17:37790339chr17:40055038ENST00000394267+57119_136112.33333333333333169.0Compositional biasNote=Asp/Glu-rich (acidic)
TgeneACLYchr17:37790339chr17:40055038ENST0000035203510294_265394.33333333333331102.0DomainNote=ATP-grasp
TgeneACLYchr17:37790339chr17:40055038ENST0000035319610284_265394.33333333333331092.0DomainNote=ATP-grasp
TgeneACLYchr17:37790339chr17:40055038ENST0000039389610284_265394.33333333333331092.0DomainNote=ATP-grasp
TgeneACLYchr17:37790339chr17:40055038ENST0000059015110294_265394.33333333333331102.0DomainNote=ATP-grasp
TgeneACLYchr17:37790339chr17:40055038ENST000003520351029109_111394.33333333333331102.0Nucleotide bindingNote=ATP
TgeneACLYchr17:37790339chr17:40055038ENST00000352035102966_67394.33333333333331102.0Nucleotide bindingNote=ATP
TgeneACLYchr17:37790339chr17:40055038ENST000003531961028109_111394.33333333333331092.0Nucleotide bindingNote=ATP
TgeneACLYchr17:37790339chr17:40055038ENST00000353196102866_67394.33333333333331092.0Nucleotide bindingNote=ATP
TgeneACLYchr17:37790339chr17:40055038ENST000003938961028109_111394.33333333333331092.0Nucleotide bindingNote=ATP
TgeneACLYchr17:37790339chr17:40055038ENST00000393896102866_67394.33333333333331092.0Nucleotide bindingNote=ATP
TgeneACLYchr17:37790339chr17:40055038ENST000005901511029109_111394.33333333333331102.0Nucleotide bindingNote=ATP
TgeneACLYchr17:37790339chr17:40055038ENST00000590151102966_67394.33333333333331102.0Nucleotide bindingNote=ATP


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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
PPP1R1B
ACLY


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to PPP1R1B-ACLY


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to PPP1R1B-ACLY


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource