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Center for Computational Systems Medicine level1
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:PRDM1-SLC22A16

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: PRDM1-SLC22A16
FusionPDB ID: 68440
FusionGDB2.0 ID: 68440
HgeneTgene
Gene symbol

PRDM1

SLC22A16

Gene ID

639

85413

Gene namePR/SET domain 1solute carrier family 22 member 16
SynonymsBLIMP1|PRDI-BF1CT2|FLIPT2|HEL-S-18|OAT6|OCT6|OKB1|dJ261K5.1
Cytomap

6q21

6q21|6q21-q22.1

Type of geneprotein-codingprotein-coding
DescriptionPR domain zinc finger protein 1B-lymphocyte-induced maturation protein 1BLIMP-1PR domain 1PR domain containing 1, with ZNF domainPRDI-binding factor-1beta-interferon gene positive-regulatory domain I binding factorsolute carrier family 22 member 16WUGSC:RG331P03.1carnitine transporter 2epididymis secretory protein Li 18flipt 2fly-like putative organic ion transporter 2fly-like putative transporter 2organic cation transporter 6organic cation transporter OKB1
Modification date2020032220200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST idsENST00000369089, ENST00000369091, 
ENST00000369096, 		ENST00000456137, 
ENST00000461487, ENST00000330550, 
ENST00000368919, ENST00000439654, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score3 X 3 X 2=184 X 5 X 5=100
# samples 39
** MAII scorelog2(3/18*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(9/100*10)=-0.15200309344505
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: PRDM1 [Title/Abstract] AND SLC22A16 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)PRDM1(106554374)-SLC22A16(110778220), # samples:1
PRDM1(106554374)-SLC22A16(110763978), # samples:1
Anticipated loss of major functional domain due to fusion event.PRDM1-SLC22A16 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
PRDM1-SLC22A16 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
PRDM1-SLC22A16 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
PRDM1-SLC22A16 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
PRDM1-SLC22A16 seems lost the major protein functional domain in Hgene partner, which is a CGC due to the frame-shifted ORF.
PRDM1-SLC22A16 seems lost the major protein functional domain in Hgene partner, which is a epigenetic factor due to the frame-shifted ORF.
PRDM1-SLC22A16 seems lost the major protein functional domain in Hgene partner, which is a transcription factor due to the frame-shifted ORF.
PRDM1-SLC22A16 seems lost the major protein functional domain in Hgene partner, which is a tumor suppressor due to the frame-shifted ORF.
PRDM1-SLC22A16 seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgenePRDM1

GO:0000122

negative regulation of transcription by RNA polymerase II

1851123

TgeneSLC22A16

GO:0015695

organic cation transport

12089149|15963465

TgeneSLC22A16

GO:0015879

carnitine transport

12089149

TgeneSLC22A16

GO:0046717

acid secretion

12089149


check buttonFusion gene breakpoints across PRDM1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across SLC22A16 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-A2-A04V-01APRDM1chr6

106554374

-SLC22A16chr6

110763978

-
ChimerDB4BRCATCGA-A2-A04V-01APRDM1chr6

106554374

+SLC22A16chr6

110778220

-


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000369091PRDM1chr6106554374+ENST00000456137SLC22A16chr6110778220-315520141032154683
ENST00000369096PRDM1chr6106554374+ENST00000456137SLC22A16chr6110778220-32772136572276739
ENST00000369089PRDM1chr6106554374+ENST00000456137SLC22A16chr6110778220-278716461461786546
ENST00000369091PRDM1chr6106554374-ENST00000368919SLC22A16chr6110763978-328320141033096997
ENST00000369091PRDM1chr6106554374-ENST00000330550SLC22A16chr6110763978-323920141033096997
ENST00000369091PRDM1chr6106554374-ENST00000439654SLC22A16chr6110763978-291120141032910936
ENST00000369096PRDM1chr6106554374-ENST00000368919SLC22A16chr6110763978-340521365732181053
ENST00000369096PRDM1chr6106554374-ENST00000330550SLC22A16chr6110763978-336121365732181053
ENST00000369096PRDM1chr6106554374-ENST00000439654SLC22A16chr6110763978-30332136573032991
ENST00000369089PRDM1chr6106554374-ENST00000368919SLC22A16chr6110763978-291516461462728860
ENST00000369089PRDM1chr6106554374-ENST00000330550SLC22A16chr6110763978-287116461462728860
ENST00000369089PRDM1chr6106554374-ENST00000439654SLC22A16chr6110763978-254316461462542799

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000369091ENST00000456137PRDM1chr6106554374+SLC22A16chr6110778220-0.0051459980.99485403
ENST00000369096ENST00000456137PRDM1chr6106554374+SLC22A16chr6110778220-0.0059514050.9940486
ENST00000369089ENST00000456137PRDM1chr6106554374+SLC22A16chr6110778220-0.0136389190.986361
ENST00000369091ENST00000368919PRDM1chr6106554374-SLC22A16chr6110763978-0.0004851230.99951494
ENST00000369091ENST00000330550PRDM1chr6106554374-SLC22A16chr6110763978-0.0005541880.99944586
ENST00000369091ENST00000439654PRDM1chr6106554374-SLC22A16chr6110763978-0.0016536770.9983463
ENST00000369096ENST00000368919PRDM1chr6106554374-SLC22A16chr6110763978-0.0007673330.99923265
ENST00000369096ENST00000330550PRDM1chr6106554374-SLC22A16chr6110763978-0.0008233090.9991767
ENST00000369096ENST00000439654PRDM1chr6106554374-SLC22A16chr6110763978-0.0014651160.9985349
ENST00000369089ENST00000368919PRDM1chr6106554374-SLC22A16chr6110763978-0.0004221120.99957794
ENST00000369089ENST00000330550PRDM1chr6106554374-SLC22A16chr6110763978-0.0005326930.9994673
ENST00000369089ENST00000439654PRDM1chr6106554374-SLC22A16chr6110763978-0.0022476410.99775237

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>68440_68440_1_PRDM1-SLC22A16_PRDM1_chr6_106554374_ENST00000369089_SLC22A16_chr6_110763978_ENST00000330550_length(amino acids)=860AA_BP=499
MEKIYSRGELHHFIDGFNEEKSNWMRYVNPAHSPREQNLAACQNGMNIYFYTIKPIPANQELLVWYCRDFAERLHYPYPGELTMMNLTQT
QSSLKQPSTEKNELCPKNVPKREYSVKEILKLDSNPSKGKDLYRSNISPLTSEKDLDDFRRRGSPEMPFYPRVVYPIRAPLPEDFLKASL
AYGIERPTYITRSPIPSSTTPSPSARSSPDQSLKSSSPHSSPGNTVSPVGPGSQEHRDSYAYLNASYGTEGLGSYPGYAPLPHLPPAFIP
SYNAHYPKFLLPPYGMNCNGLSAVSSMNGINNFGLFPRLCPVYSNLLGGGSLPHPMLNPTSLPSSLPSDGARRLLQPEHPREVLVPAPHS
AFSFTGAAASMKDKACSPTSGSPTAGTAATAEHVVQPKATSAAMAAPSSDEAMNLIKNKRNMTGYKTLPYPLKKQNGKIKYECNVCAKTF
GQLSNLKVHLRVHSGERPFKCQTCNKGFTQLAHLQKHYLVHTGEKPHECQVASGYLVVGFVYVMEFIGMKSRTWASVHLHSFFAVGTLLV
ALTGYLVRTWWLYQMILSTVTVPFILCCWVLPETPFWLLSEGRYEEAQKIVDIMAKWNRASSCKLSELLSLDLQGPVSNSPTEVQKHNLS
YLFYNWSITKRTLTVWLIWFTGSLGFYSFSLNSVNLGGNEYLNLFLLGVVEIPAYTFVCIAMDKVGRRTVLAYSLFCSALACGVVMVIPQ
KHYILGVVTAMVGKFAIGAAFGLIYLYTAELYPTIVRSLAVGSGSMVCRLASILAPFSVDLSSIWIFIPQLFVGTMALLSGVLTLKLPET

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>68440_68440_2_PRDM1-SLC22A16_PRDM1_chr6_106554374_ENST00000369089_SLC22A16_chr6_110763978_ENST00000368919_length(amino acids)=860AA_BP=499
MEKIYSRGELHHFIDGFNEEKSNWMRYVNPAHSPREQNLAACQNGMNIYFYTIKPIPANQELLVWYCRDFAERLHYPYPGELTMMNLTQT
QSSLKQPSTEKNELCPKNVPKREYSVKEILKLDSNPSKGKDLYRSNISPLTSEKDLDDFRRRGSPEMPFYPRVVYPIRAPLPEDFLKASL
AYGIERPTYITRSPIPSSTTPSPSARSSPDQSLKSSSPHSSPGNTVSPVGPGSQEHRDSYAYLNASYGTEGLGSYPGYAPLPHLPPAFIP
SYNAHYPKFLLPPYGMNCNGLSAVSSMNGINNFGLFPRLCPVYSNLLGGGSLPHPMLNPTSLPSSLPSDGARRLLQPEHPREVLVPAPHS
AFSFTGAAASMKDKACSPTSGSPTAGTAATAEHVVQPKATSAAMAAPSSDEAMNLIKNKRNMTGYKTLPYPLKKQNGKIKYECNVCAKTF
GQLSNLKVHLRVHSGERPFKCQTCNKGFTQLAHLQKHYLVHTGEKPHECQVASGYLVVGFVYVMEFIGMKSRTWASVHLHSFFAVGTLLV
ALTGYLVRTWWLYQMILSTVTVPFILCCWVLPETPFWLLSEGRYEEAQKIVDIMAKWNRASSCKLSELLSLDLQGPVSNSPTEVQKHNLS
YLFYNWSITKRTLTVWLIWFTGSLGFYSFSLNSVNLGGNEYLNLFLLGVVEIPAYTFVCIAMDKVGRRTVLAYSLFCSALACGVVMVIPQ
KHYILGVVTAMVGKFAIGAAFGLIYLYTAELYPTIVRSLAVGSGSMVCRLASILAPFSVDLSSIWIFIPQLFVGTMALLSGVLTLKLPET

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>68440_68440_3_PRDM1-SLC22A16_PRDM1_chr6_106554374_ENST00000369089_SLC22A16_chr6_110763978_ENST00000439654_length(amino acids)=799AA_BP=499
MEKIYSRGELHHFIDGFNEEKSNWMRYVNPAHSPREQNLAACQNGMNIYFYTIKPIPANQELLVWYCRDFAERLHYPYPGELTMMNLTQT
QSSLKQPSTEKNELCPKNVPKREYSVKEILKLDSNPSKGKDLYRSNISPLTSEKDLDDFRRRGSPEMPFYPRVVYPIRAPLPEDFLKASL
AYGIERPTYITRSPIPSSTTPSPSARSSPDQSLKSSSPHSSPGNTVSPVGPGSQEHRDSYAYLNASYGTEGLGSYPGYAPLPHLPPAFIP
SYNAHYPKFLLPPYGMNCNGLSAVSSMNGINNFGLFPRLCPVYSNLLGGGSLPHPMLNPTSLPSSLPSDGARRLLQPEHPREVLVPAPHS
AFSFTGAAASMKDKACSPTSGSPTAGTAATAEHVVQPKATSAAMAAPSSDEAMNLIKNKRNMTGYKTLPYPLKKQNGKIKYECNVCAKTF
GQLSNLKVHLRVHSGERPFKCQTCNKGFTQLAHLQKHYLVHTGEKPHECQVASGYLVVGFVYVMEFIGMKSRTWASVHLHSFFAVGTLLV
ALTGYLVRTWWLYQMILSTVTVPFILCCWVLPETPFWLLSEGRYEEAQKIVDIMAKWNRASSCKLSELLSLDLQGPVSNSPTEVQKHNLS
YLFYNWSITKRTLTVWLIWFTGSLGFYSFSLNSVNLGGNEYLNLFLLGVVEIPAYTFVCIAMDKVGRRTVLAYSLFCSALACGVVMVIPQ

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>68440_68440_4_PRDM1-SLC22A16_PRDM1_chr6_106554374_ENST00000369089_SLC22A16_chr6_110778220_ENST00000456137_length(amino acids)=546AA_BP=499
MEKIYSRGELHHFIDGFNEEKSNWMRYVNPAHSPREQNLAACQNGMNIYFYTIKPIPANQELLVWYCRDFAERLHYPYPGELTMMNLTQT
QSSLKQPSTEKNELCPKNVPKREYSVKEILKLDSNPSKGKDLYRSNISPLTSEKDLDDFRRRGSPEMPFYPRVVYPIRAPLPEDFLKASL
AYGIERPTYITRSPIPSSTTPSPSARSSPDQSLKSSSPHSSPGNTVSPVGPGSQEHRDSYAYLNASYGTEGLGSYPGYAPLPHLPPAFIP
SYNAHYPKFLLPPYGMNCNGLSAVSSMNGINNFGLFPRLCPVYSNLLGGGSLPHPMLNPTSLPSSLPSDGARRLLQPEHPREVLVPAPHS
AFSFTGAAASMKDKACSPTSGSPTAGTAATAEHVVQPKATSAAMAAPSSDEAMNLIKNKRNMTGYKTLPYPLKKQNGKIKYECNVCAKTF
GQLSNLKVHLRVHSGERPFKCQTCNKGFTQLAHLQKHYLVHTGEKPHECQIPESPLFHMCLPEHLLWYSLLGFCVHGSHPSSCLQAPRQC

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>68440_68440_5_PRDM1-SLC22A16_PRDM1_chr6_106554374_ENST00000369091_SLC22A16_chr6_110763978_ENST00000330550_length(amino acids)=997AA_BP=636
MGRGRPGGRTKRGGTAEAAPKCNSSTVRFQGLAEGTKGTMKMDMEDADMTLWTEAEFEEKCTYIVNDHPWDSGADGGTSVQAEASLPRNL
LFKYATNSEEVIGVMSKEYIPKGTRFGPLIGEIYTNDTVPKNANRKYFWRIYSRGELHHFIDGFNEEKSNWMRYVNPAHSPREQNLAACQ
NGMNIYFYTIKPIPANQELLVWYCRDFAERLHYPYPGELTMMNLTQTQSSLKQPSTEKNELCPKNVPKREYSVKEILKLDSNPSKGKDLY
RSNISPLTSEKDLDDFRRRGSPEMPFYPRVVYPIRAPLPEDFLKASLAYGIERPTYITRSPIPSSTTPSPSARSSPDQSLKSSSPHSSPG
NTVSPVGPGSQEHRDSYAYLNASYGTEGLGSYPGYAPLPHLPPAFIPSYNAHYPKFLLPPYGMNCNGLSAVSSMNGINNFGLFPRLCPVY
SNLLGGGSLPHPMLNPTSLPSSLPSDGARRLLQPEHPREVLVPAPHSAFSFTGAAASMKDKACSPTSGSPTAGTAATAEHVVQPKATSAA
MAAPSSDEAMNLIKNKRNMTGYKTLPYPLKKQNGKIKYECNVCAKTFGQLSNLKVHLRVHSGERPFKCQTCNKGFTQLAHLQKHYLVHTG
EKPHECQVASGYLVVGFVYVMEFIGMKSRTWASVHLHSFFAVGTLLVALTGYLVRTWWLYQMILSTVTVPFILCCWVLPETPFWLLSEGR
YEEAQKIVDIMAKWNRASSCKLSELLSLDLQGPVSNSPTEVQKHNLSYLFYNWSITKRTLTVWLIWFTGSLGFYSFSLNSVNLGGNEYLN
LFLLGVVEIPAYTFVCIAMDKVGRRTVLAYSLFCSALACGVVMVIPQKHYILGVVTAMVGKFAIGAAFGLIYLYTAELYPTIVRSLAVGS
GSMVCRLASILAPFSVDLSSIWIFIPQLFVGTMALLSGVLTLKLPETLGKRLATTWEEAAKLESENESKSSKLLLTTNNSGLEKTEAITP

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>68440_68440_6_PRDM1-SLC22A16_PRDM1_chr6_106554374_ENST00000369091_SLC22A16_chr6_110763978_ENST00000368919_length(amino acids)=997AA_BP=636
MGRGRPGGRTKRGGTAEAAPKCNSSTVRFQGLAEGTKGTMKMDMEDADMTLWTEAEFEEKCTYIVNDHPWDSGADGGTSVQAEASLPRNL
LFKYATNSEEVIGVMSKEYIPKGTRFGPLIGEIYTNDTVPKNANRKYFWRIYSRGELHHFIDGFNEEKSNWMRYVNPAHSPREQNLAACQ
NGMNIYFYTIKPIPANQELLVWYCRDFAERLHYPYPGELTMMNLTQTQSSLKQPSTEKNELCPKNVPKREYSVKEILKLDSNPSKGKDLY
RSNISPLTSEKDLDDFRRRGSPEMPFYPRVVYPIRAPLPEDFLKASLAYGIERPTYITRSPIPSSTTPSPSARSSPDQSLKSSSPHSSPG
NTVSPVGPGSQEHRDSYAYLNASYGTEGLGSYPGYAPLPHLPPAFIPSYNAHYPKFLLPPYGMNCNGLSAVSSMNGINNFGLFPRLCPVY
SNLLGGGSLPHPMLNPTSLPSSLPSDGARRLLQPEHPREVLVPAPHSAFSFTGAAASMKDKACSPTSGSPTAGTAATAEHVVQPKATSAA
MAAPSSDEAMNLIKNKRNMTGYKTLPYPLKKQNGKIKYECNVCAKTFGQLSNLKVHLRVHSGERPFKCQTCNKGFTQLAHLQKHYLVHTG
EKPHECQVASGYLVVGFVYVMEFIGMKSRTWASVHLHSFFAVGTLLVALTGYLVRTWWLYQMILSTVTVPFILCCWVLPETPFWLLSEGR
YEEAQKIVDIMAKWNRASSCKLSELLSLDLQGPVSNSPTEVQKHNLSYLFYNWSITKRTLTVWLIWFTGSLGFYSFSLNSVNLGGNEYLN
LFLLGVVEIPAYTFVCIAMDKVGRRTVLAYSLFCSALACGVVMVIPQKHYILGVVTAMVGKFAIGAAFGLIYLYTAELYPTIVRSLAVGS
GSMVCRLASILAPFSVDLSSIWIFIPQLFVGTMALLSGVLTLKLPETLGKRLATTWEEAAKLESENESKSSKLLLTTNNSGLEKTEAITP

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>68440_68440_7_PRDM1-SLC22A16_PRDM1_chr6_106554374_ENST00000369091_SLC22A16_chr6_110763978_ENST00000439654_length(amino acids)=936AA_BP=636
MGRGRPGGRTKRGGTAEAAPKCNSSTVRFQGLAEGTKGTMKMDMEDADMTLWTEAEFEEKCTYIVNDHPWDSGADGGTSVQAEASLPRNL
LFKYATNSEEVIGVMSKEYIPKGTRFGPLIGEIYTNDTVPKNANRKYFWRIYSRGELHHFIDGFNEEKSNWMRYVNPAHSPREQNLAACQ
NGMNIYFYTIKPIPANQELLVWYCRDFAERLHYPYPGELTMMNLTQTQSSLKQPSTEKNELCPKNVPKREYSVKEILKLDSNPSKGKDLY
RSNISPLTSEKDLDDFRRRGSPEMPFYPRVVYPIRAPLPEDFLKASLAYGIERPTYITRSPIPSSTTPSPSARSSPDQSLKSSSPHSSPG
NTVSPVGPGSQEHRDSYAYLNASYGTEGLGSYPGYAPLPHLPPAFIPSYNAHYPKFLLPPYGMNCNGLSAVSSMNGINNFGLFPRLCPVY
SNLLGGGSLPHPMLNPTSLPSSLPSDGARRLLQPEHPREVLVPAPHSAFSFTGAAASMKDKACSPTSGSPTAGTAATAEHVVQPKATSAA
MAAPSSDEAMNLIKNKRNMTGYKTLPYPLKKQNGKIKYECNVCAKTFGQLSNLKVHLRVHSGERPFKCQTCNKGFTQLAHLQKHYLVHTG
EKPHECQVASGYLVVGFVYVMEFIGMKSRTWASVHLHSFFAVGTLLVALTGYLVRTWWLYQMILSTVTVPFILCCWVLPETPFWLLSEGR
YEEAQKIVDIMAKWNRASSCKLSELLSLDLQGPVSNSPTEVQKHNLSYLFYNWSITKRTLTVWLIWFTGSLGFYSFSLNSVNLGGNEYLN
LFLLGVVEIPAYTFVCIAMDKVGRRTVLAYSLFCSALACGVVMVIPQKHYILGVVTAMVGKFAIGAAFGLIYLYTAELYPTIVRSLAVGS

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>68440_68440_8_PRDM1-SLC22A16_PRDM1_chr6_106554374_ENST00000369091_SLC22A16_chr6_110778220_ENST00000456137_length(amino acids)=683AA_BP=636
MGRGRPGGRTKRGGTAEAAPKCNSSTVRFQGLAEGTKGTMKMDMEDADMTLWTEAEFEEKCTYIVNDHPWDSGADGGTSVQAEASLPRNL
LFKYATNSEEVIGVMSKEYIPKGTRFGPLIGEIYTNDTVPKNANRKYFWRIYSRGELHHFIDGFNEEKSNWMRYVNPAHSPREQNLAACQ
NGMNIYFYTIKPIPANQELLVWYCRDFAERLHYPYPGELTMMNLTQTQSSLKQPSTEKNELCPKNVPKREYSVKEILKLDSNPSKGKDLY
RSNISPLTSEKDLDDFRRRGSPEMPFYPRVVYPIRAPLPEDFLKASLAYGIERPTYITRSPIPSSTTPSPSARSSPDQSLKSSSPHSSPG
NTVSPVGPGSQEHRDSYAYLNASYGTEGLGSYPGYAPLPHLPPAFIPSYNAHYPKFLLPPYGMNCNGLSAVSSMNGINNFGLFPRLCPVY
SNLLGGGSLPHPMLNPTSLPSSLPSDGARRLLQPEHPREVLVPAPHSAFSFTGAAASMKDKACSPTSGSPTAGTAATAEHVVQPKATSAA
MAAPSSDEAMNLIKNKRNMTGYKTLPYPLKKQNGKIKYECNVCAKTFGQLSNLKVHLRVHSGERPFKCQTCNKGFTQLAHLQKHYLVHTG

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>68440_68440_9_PRDM1-SLC22A16_PRDM1_chr6_106554374_ENST00000369096_SLC22A16_chr6_110763978_ENST00000330550_length(amino acids)=1053AA_BP=692
MRRGKSSDRGTCPPGAGTRAPGRPDEARRDRRGARLCGSAWRGTRGECGLGRDERDFSQMLDICLEKRVGTTLAAPKCNSSTVRFQGLAE
GTKGTMKMDMEDADMTLWTEAEFEEKCTYIVNDHPWDSGADGGTSVQAEASLPRNLLFKYATNSEEVIGVMSKEYIPKGTRFGPLIGEIY
TNDTVPKNANRKYFWRIYSRGELHHFIDGFNEEKSNWMRYVNPAHSPREQNLAACQNGMNIYFYTIKPIPANQELLVWYCRDFAERLHYP
YPGELTMMNLTQTQSSLKQPSTEKNELCPKNVPKREYSVKEILKLDSNPSKGKDLYRSNISPLTSEKDLDDFRRRGSPEMPFYPRVVYPI
RAPLPEDFLKASLAYGIERPTYITRSPIPSSTTPSPSARSSPDQSLKSSSPHSSPGNTVSPVGPGSQEHRDSYAYLNASYGTEGLGSYPG
YAPLPHLPPAFIPSYNAHYPKFLLPPYGMNCNGLSAVSSMNGINNFGLFPRLCPVYSNLLGGGSLPHPMLNPTSLPSSLPSDGARRLLQP
EHPREVLVPAPHSAFSFTGAAASMKDKACSPTSGSPTAGTAATAEHVVQPKATSAAMAAPSSDEAMNLIKNKRNMTGYKTLPYPLKKQNG
KIKYECNVCAKTFGQLSNLKVHLRVHSGERPFKCQTCNKGFTQLAHLQKHYLVHTGEKPHECQVASGYLVVGFVYVMEFIGMKSRTWASV
HLHSFFAVGTLLVALTGYLVRTWWLYQMILSTVTVPFILCCWVLPETPFWLLSEGRYEEAQKIVDIMAKWNRASSCKLSELLSLDLQGPV
SNSPTEVQKHNLSYLFYNWSITKRTLTVWLIWFTGSLGFYSFSLNSVNLGGNEYLNLFLLGVVEIPAYTFVCIAMDKVGRRTVLAYSLFC
SALACGVVMVIPQKHYILGVVTAMVGKFAIGAAFGLIYLYTAELYPTIVRSLAVGSGSMVCRLASILAPFSVDLSSIWIFIPQLFVGTMA

--------------------------------------------------------------

>68440_68440_10_PRDM1-SLC22A16_PRDM1_chr6_106554374_ENST00000369096_SLC22A16_chr6_110763978_ENST00000368919_length(amino acids)=1053AA_BP=692
MRRGKSSDRGTCPPGAGTRAPGRPDEARRDRRGARLCGSAWRGTRGECGLGRDERDFSQMLDICLEKRVGTTLAAPKCNSSTVRFQGLAE
GTKGTMKMDMEDADMTLWTEAEFEEKCTYIVNDHPWDSGADGGTSVQAEASLPRNLLFKYATNSEEVIGVMSKEYIPKGTRFGPLIGEIY
TNDTVPKNANRKYFWRIYSRGELHHFIDGFNEEKSNWMRYVNPAHSPREQNLAACQNGMNIYFYTIKPIPANQELLVWYCRDFAERLHYP
YPGELTMMNLTQTQSSLKQPSTEKNELCPKNVPKREYSVKEILKLDSNPSKGKDLYRSNISPLTSEKDLDDFRRRGSPEMPFYPRVVYPI
RAPLPEDFLKASLAYGIERPTYITRSPIPSSTTPSPSARSSPDQSLKSSSPHSSPGNTVSPVGPGSQEHRDSYAYLNASYGTEGLGSYPG
YAPLPHLPPAFIPSYNAHYPKFLLPPYGMNCNGLSAVSSMNGINNFGLFPRLCPVYSNLLGGGSLPHPMLNPTSLPSSLPSDGARRLLQP
EHPREVLVPAPHSAFSFTGAAASMKDKACSPTSGSPTAGTAATAEHVVQPKATSAAMAAPSSDEAMNLIKNKRNMTGYKTLPYPLKKQNG
KIKYECNVCAKTFGQLSNLKVHLRVHSGERPFKCQTCNKGFTQLAHLQKHYLVHTGEKPHECQVASGYLVVGFVYVMEFIGMKSRTWASV
HLHSFFAVGTLLVALTGYLVRTWWLYQMILSTVTVPFILCCWVLPETPFWLLSEGRYEEAQKIVDIMAKWNRASSCKLSELLSLDLQGPV
SNSPTEVQKHNLSYLFYNWSITKRTLTVWLIWFTGSLGFYSFSLNSVNLGGNEYLNLFLLGVVEIPAYTFVCIAMDKVGRRTVLAYSLFC
SALACGVVMVIPQKHYILGVVTAMVGKFAIGAAFGLIYLYTAELYPTIVRSLAVGSGSMVCRLASILAPFSVDLSSIWIFIPQLFVGTMA

--------------------------------------------------------------

>68440_68440_11_PRDM1-SLC22A16_PRDM1_chr6_106554374_ENST00000369096_SLC22A16_chr6_110763978_ENST00000439654_length(amino acids)=991AA_BP=692
MRRGKSSDRGTCPPGAGTRAPGRPDEARRDRRGARLCGSAWRGTRGECGLGRDERDFSQMLDICLEKRVGTTLAAPKCNSSTVRFQGLAE
GTKGTMKMDMEDADMTLWTEAEFEEKCTYIVNDHPWDSGADGGTSVQAEASLPRNLLFKYATNSEEVIGVMSKEYIPKGTRFGPLIGEIY
TNDTVPKNANRKYFWRIYSRGELHHFIDGFNEEKSNWMRYVNPAHSPREQNLAACQNGMNIYFYTIKPIPANQELLVWYCRDFAERLHYP
YPGELTMMNLTQTQSSLKQPSTEKNELCPKNVPKREYSVKEILKLDSNPSKGKDLYRSNISPLTSEKDLDDFRRRGSPEMPFYPRVVYPI
RAPLPEDFLKASLAYGIERPTYITRSPIPSSTTPSPSARSSPDQSLKSSSPHSSPGNTVSPVGPGSQEHRDSYAYLNASYGTEGLGSYPG
YAPLPHLPPAFIPSYNAHYPKFLLPPYGMNCNGLSAVSSMNGINNFGLFPRLCPVYSNLLGGGSLPHPMLNPTSLPSSLPSDGARRLLQP
EHPREVLVPAPHSAFSFTGAAASMKDKACSPTSGSPTAGTAATAEHVVQPKATSAAMAAPSSDEAMNLIKNKRNMTGYKTLPYPLKKQNG
KIKYECNVCAKTFGQLSNLKVHLRVHSGERPFKCQTCNKGFTQLAHLQKHYLVHTGEKPHECQVASGYLVVGFVYVMEFIGMKSRTWASV
HLHSFFAVGTLLVALTGYLVRTWWLYQMILSTVTVPFILCCWVLPETPFWLLSEGRYEEAQKIVDIMAKWNRASSCKLSELLSLDLQGPV
SNSPTEVQKHNLSYLFYNWSITKRTLTVWLIWFTGSLGFYSFSLNSVNLGGNEYLNLFLLGVVEIPAYTFVCIAMDKVGRRTVLAYSLFC
SALACGVVMVIPQKHYILGVVTAMVGKFAIGAAFGLIYLYTAELYPTIVRSLAVGSGSMVCRLASILAPFSVDLSSIWIFIPQLLGQHLQ

--------------------------------------------------------------

>68440_68440_12_PRDM1-SLC22A16_PRDM1_chr6_106554374_ENST00000369096_SLC22A16_chr6_110778220_ENST00000456137_length(amino acids)=739AA_BP=692
MRRGKSSDRGTCPPGAGTRAPGRPDEARRDRRGARLCGSAWRGTRGECGLGRDERDFSQMLDICLEKRVGTTLAAPKCNSSTVRFQGLAE
GTKGTMKMDMEDADMTLWTEAEFEEKCTYIVNDHPWDSGADGGTSVQAEASLPRNLLFKYATNSEEVIGVMSKEYIPKGTRFGPLIGEIY
TNDTVPKNANRKYFWRIYSRGELHHFIDGFNEEKSNWMRYVNPAHSPREQNLAACQNGMNIYFYTIKPIPANQELLVWYCRDFAERLHYP
YPGELTMMNLTQTQSSLKQPSTEKNELCPKNVPKREYSVKEILKLDSNPSKGKDLYRSNISPLTSEKDLDDFRRRGSPEMPFYPRVVYPI
RAPLPEDFLKASLAYGIERPTYITRSPIPSSTTPSPSARSSPDQSLKSSSPHSSPGNTVSPVGPGSQEHRDSYAYLNASYGTEGLGSYPG
YAPLPHLPPAFIPSYNAHYPKFLLPPYGMNCNGLSAVSSMNGINNFGLFPRLCPVYSNLLGGGSLPHPMLNPTSLPSSLPSDGARRLLQP
EHPREVLVPAPHSAFSFTGAAASMKDKACSPTSGSPTAGTAATAEHVVQPKATSAAMAAPSSDEAMNLIKNKRNMTGYKTLPYPLKKQNG
KIKYECNVCAKTFGQLSNLKVHLRVHSGERPFKCQTCNKGFTQLAHLQKHYLVHTGEKPHECQIPESPLFHMCLPEHLLWYSLLGFCVHG

--------------------------------------------------------------

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr6:106554374/chr6:110778220)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePRDM1chr6:106554374chr6:110763978ENST00000369089-4584_201500.0692.0DomainSET
HgenePRDM1chr6:106554374chr6:110763978ENST00000369091-6784_201598.0790.0DomainSET
HgenePRDM1chr6:106554374chr6:110763978ENST00000369096-6784_201634.0826.0DomainSET
HgenePRDM1chr6:106554374chr6:110778220ENST00000369089+4584_201500.0692.0DomainSET
HgenePRDM1chr6:106554374chr6:110778220ENST00000369091+6784_201598.0790.0DomainSET
HgenePRDM1chr6:106554374chr6:110778220ENST00000369096+6784_201634.0826.0DomainSET
HgenePRDM1chr6:106554374chr6:110763978ENST00000369091-67575_597598.0790.0Zinc fingerC2H2-type 1
HgenePRDM1chr6:106554374chr6:110763978ENST00000369096-67575_597634.0826.0Zinc fingerC2H2-type 1
HgenePRDM1chr6:106554374chr6:110763978ENST00000369096-67603_625634.0826.0Zinc fingerC2H2-type 2
HgenePRDM1chr6:106554374chr6:110778220ENST00000369091+67575_597598.0790.0Zinc fingerC2H2-type 1
HgenePRDM1chr6:106554374chr6:110778220ENST00000369096+67575_597634.0826.0Zinc fingerC2H2-type 1
HgenePRDM1chr6:106554374chr6:110778220ENST00000369096+67603_625634.0826.0Zinc fingerC2H2-type 2
TgeneSLC22A16chr6:106554374chr6:110763978ENST0000033055039183_203183.0544.0TransmembraneHelical
TgeneSLC22A16chr6:106554374chr6:110763978ENST0000033055039214_234183.0544.0TransmembraneHelical
TgeneSLC22A16chr6:106554374chr6:110763978ENST0000033055039244_264183.0544.0TransmembraneHelical
TgeneSLC22A16chr6:106554374chr6:110763978ENST0000033055039268_288183.0544.0TransmembraneHelical
TgeneSLC22A16chr6:106554374chr6:110763978ENST0000033055039359_379183.0544.0TransmembraneHelical
TgeneSLC22A16chr6:106554374chr6:110763978ENST0000033055039389_409183.0544.0TransmembraneHelical
TgeneSLC22A16chr6:106554374chr6:110763978ENST0000033055039416_436183.0544.0TransmembraneHelical
TgeneSLC22A16chr6:106554374chr6:110763978ENST0000033055039441_461183.0544.0TransmembraneHelical
TgeneSLC22A16chr6:106554374chr6:110763978ENST0000033055039476_496183.0544.0TransmembraneHelical
TgeneSLC22A16chr6:106554374chr6:110763978ENST0000033055039501_521183.0544.0TransmembraneHelical
TgeneSLC22A16chr6:106554374chr6:110763978ENST0000036891928214_234217.0578.0TransmembraneHelical
TgeneSLC22A16chr6:106554374chr6:110763978ENST0000036891928244_264217.0578.0TransmembraneHelical
TgeneSLC22A16chr6:106554374chr6:110763978ENST0000036891928268_288217.0578.0TransmembraneHelical
TgeneSLC22A16chr6:106554374chr6:110763978ENST0000036891928359_379217.0578.0TransmembraneHelical
TgeneSLC22A16chr6:106554374chr6:110763978ENST0000036891928389_409217.0578.0TransmembraneHelical
TgeneSLC22A16chr6:106554374chr6:110763978ENST0000036891928416_436217.0578.0TransmembraneHelical
TgeneSLC22A16chr6:106554374chr6:110763978ENST0000036891928441_461217.0578.0TransmembraneHelical
TgeneSLC22A16chr6:106554374chr6:110763978ENST0000036891928476_496217.0578.0TransmembraneHelical
TgeneSLC22A16chr6:106554374chr6:110763978ENST0000036891928501_521217.0578.0TransmembraneHelical
TgeneSLC22A16chr6:106554374chr6:110763978ENST0000043965428214_234217.0516.0TransmembraneHelical
TgeneSLC22A16chr6:106554374chr6:110763978ENST0000043965428244_264217.0516.0TransmembraneHelical
TgeneSLC22A16chr6:106554374chr6:110763978ENST0000043965428268_288217.0516.0TransmembraneHelical
TgeneSLC22A16chr6:106554374chr6:110763978ENST0000043965428359_379217.0516.0TransmembraneHelical
TgeneSLC22A16chr6:106554374chr6:110763978ENST0000043965428389_409217.0516.0TransmembraneHelical
TgeneSLC22A16chr6:106554374chr6:110763978ENST0000043965428416_436217.0516.0TransmembraneHelical
TgeneSLC22A16chr6:106554374chr6:110763978ENST0000043965428441_461217.0516.0TransmembraneHelical
TgeneSLC22A16chr6:106554374chr6:110763978ENST0000043965428476_496217.0516.0TransmembraneHelical
TgeneSLC22A16chr6:106554374chr6:110763978ENST0000043965428501_521217.0516.0TransmembraneHelical
TgeneSLC22A16chr6:106554374chr6:110778220ENST0000033055009152_17215.666666666666666544.0TransmembraneHelical
TgeneSLC22A16chr6:106554374chr6:110778220ENST0000033055009183_20315.666666666666666544.0TransmembraneHelical
TgeneSLC22A16chr6:106554374chr6:110778220ENST0000033055009214_23415.666666666666666544.0TransmembraneHelical
TgeneSLC22A16chr6:106554374chr6:110778220ENST000003305500923_4315.666666666666666544.0TransmembraneHelical
TgeneSLC22A16chr6:106554374chr6:110778220ENST0000033055009244_26415.666666666666666544.0TransmembraneHelical
TgeneSLC22A16chr6:106554374chr6:110778220ENST0000033055009268_28815.666666666666666544.0TransmembraneHelical
TgeneSLC22A16chr6:106554374chr6:110778220ENST0000033055009359_37915.666666666666666544.0TransmembraneHelical
TgeneSLC22A16chr6:106554374chr6:110778220ENST0000033055009389_40915.666666666666666544.0TransmembraneHelical
TgeneSLC22A16chr6:106554374chr6:110778220ENST0000033055009416_43615.666666666666666544.0TransmembraneHelical
TgeneSLC22A16chr6:106554374chr6:110778220ENST0000033055009441_46115.666666666666666544.0TransmembraneHelical
TgeneSLC22A16chr6:106554374chr6:110778220ENST0000033055009476_49615.666666666666666544.0TransmembraneHelical
TgeneSLC22A16chr6:106554374chr6:110778220ENST0000033055009501_52115.666666666666666544.0TransmembraneHelical
TgeneSLC22A16chr6:106554374chr6:110778220ENST0000036891908152_17217.666666666666668578.0TransmembraneHelical
TgeneSLC22A16chr6:106554374chr6:110778220ENST0000036891908183_20317.666666666666668578.0TransmembraneHelical
TgeneSLC22A16chr6:106554374chr6:110778220ENST0000036891908214_23417.666666666666668578.0TransmembraneHelical
TgeneSLC22A16chr6:106554374chr6:110778220ENST000003689190823_4317.666666666666668578.0TransmembraneHelical
TgeneSLC22A16chr6:106554374chr6:110778220ENST0000036891908244_26417.666666666666668578.0TransmembraneHelical
TgeneSLC22A16chr6:106554374chr6:110778220ENST0000036891908268_28817.666666666666668578.0TransmembraneHelical
TgeneSLC22A16chr6:106554374chr6:110778220ENST0000036891908359_37917.666666666666668578.0TransmembraneHelical
TgeneSLC22A16chr6:106554374chr6:110778220ENST0000036891908389_40917.666666666666668578.0TransmembraneHelical
TgeneSLC22A16chr6:106554374chr6:110778220ENST0000036891908416_43617.666666666666668578.0TransmembraneHelical
TgeneSLC22A16chr6:106554374chr6:110778220ENST0000036891908441_46117.666666666666668578.0TransmembraneHelical
TgeneSLC22A16chr6:106554374chr6:110778220ENST0000036891908476_49617.666666666666668578.0TransmembraneHelical
TgeneSLC22A16chr6:106554374chr6:110778220ENST0000036891908501_52117.666666666666668578.0TransmembraneHelical
TgeneSLC22A16chr6:106554374chr6:110778220ENST0000043965408152_17217.666666666666668516.0TransmembraneHelical
TgeneSLC22A16chr6:106554374chr6:110778220ENST0000043965408183_20317.666666666666668516.0TransmembraneHelical
TgeneSLC22A16chr6:106554374chr6:110778220ENST0000043965408214_23417.666666666666668516.0TransmembraneHelical
TgeneSLC22A16chr6:106554374chr6:110778220ENST000004396540823_4317.666666666666668516.0TransmembraneHelical
TgeneSLC22A16chr6:106554374chr6:110778220ENST0000043965408244_26417.666666666666668516.0TransmembraneHelical
TgeneSLC22A16chr6:106554374chr6:110778220ENST0000043965408268_28817.666666666666668516.0TransmembraneHelical
TgeneSLC22A16chr6:106554374chr6:110778220ENST0000043965408359_37917.666666666666668516.0TransmembraneHelical
TgeneSLC22A16chr6:106554374chr6:110778220ENST0000043965408389_40917.666666666666668516.0TransmembraneHelical
TgeneSLC22A16chr6:106554374chr6:110778220ENST0000043965408416_43617.666666666666668516.0TransmembraneHelical
TgeneSLC22A16chr6:106554374chr6:110778220ENST0000043965408441_46117.666666666666668516.0TransmembraneHelical
TgeneSLC22A16chr6:106554374chr6:110778220ENST0000043965408476_49617.666666666666668516.0TransmembraneHelical
TgeneSLC22A16chr6:106554374chr6:110778220ENST0000043965408501_52117.666666666666668516.0TransmembraneHelical

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePRDM1chr6:106554374chr6:110763978ENST00000369089-45575_597500.0692.0Zinc fingerC2H2-type 1
HgenePRDM1chr6:106554374chr6:110763978ENST00000369089-45603_625500.0692.0Zinc fingerC2H2-type 2
HgenePRDM1chr6:106554374chr6:110763978ENST00000369089-45631_653500.0692.0Zinc fingerC2H2-type 3
HgenePRDM1chr6:106554374chr6:110763978ENST00000369089-45659_681500.0692.0Zinc fingerC2H2-type 4
HgenePRDM1chr6:106554374chr6:110763978ENST00000369091-67603_625598.0790.0Zinc fingerC2H2-type 2
HgenePRDM1chr6:106554374chr6:110763978ENST00000369091-67631_653598.0790.0Zinc fingerC2H2-type 3
HgenePRDM1chr6:106554374chr6:110763978ENST00000369091-67659_681598.0790.0Zinc fingerC2H2-type 4
HgenePRDM1chr6:106554374chr6:110763978ENST00000369096-67631_653634.0826.0Zinc fingerC2H2-type 3
HgenePRDM1chr6:106554374chr6:110763978ENST00000369096-67659_681634.0826.0Zinc fingerC2H2-type 4
HgenePRDM1chr6:106554374chr6:110778220ENST00000369089+45575_597500.0692.0Zinc fingerC2H2-type 1
HgenePRDM1chr6:106554374chr6:110778220ENST00000369089+45603_625500.0692.0Zinc fingerC2H2-type 2
HgenePRDM1chr6:106554374chr6:110778220ENST00000369089+45631_653500.0692.0Zinc fingerC2H2-type 3
HgenePRDM1chr6:106554374chr6:110778220ENST00000369089+45659_681500.0692.0Zinc fingerC2H2-type 4
HgenePRDM1chr6:106554374chr6:110778220ENST00000369091+67603_625598.0790.0Zinc fingerC2H2-type 2
HgenePRDM1chr6:106554374chr6:110778220ENST00000369091+67631_653598.0790.0Zinc fingerC2H2-type 3
HgenePRDM1chr6:106554374chr6:110778220ENST00000369091+67659_681598.0790.0Zinc fingerC2H2-type 4
HgenePRDM1chr6:106554374chr6:110778220ENST00000369096+67631_653634.0826.0Zinc fingerC2H2-type 3
HgenePRDM1chr6:106554374chr6:110778220ENST00000369096+67659_681634.0826.0Zinc fingerC2H2-type 4
TgeneSLC22A16chr6:106554374chr6:110763978ENST0000033055039152_172183.0544.0TransmembraneHelical
TgeneSLC22A16chr6:106554374chr6:110763978ENST000003305503923_43183.0544.0TransmembraneHelical
TgeneSLC22A16chr6:106554374chr6:110763978ENST0000036891928152_172217.0578.0TransmembraneHelical
TgeneSLC22A16chr6:106554374chr6:110763978ENST0000036891928183_203217.0578.0TransmembraneHelical
TgeneSLC22A16chr6:106554374chr6:110763978ENST000003689192823_43217.0578.0TransmembraneHelical
TgeneSLC22A16chr6:106554374chr6:110763978ENST0000043965428152_172217.0516.0TransmembraneHelical
TgeneSLC22A16chr6:106554374chr6:110763978ENST0000043965428183_203217.0516.0TransmembraneHelical
TgeneSLC22A16chr6:106554374chr6:110763978ENST000004396542823_43217.0516.0TransmembraneHelical


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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
PRDM1
SLC22A16


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgenePRDM1chr6:106554374chr6:110763978ENST00000369089-45527_574500.0692.0PIAS1
HgenePRDM1chr6:106554374chr6:110778220ENST00000369089+45527_574500.0692.0PIAS1


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Related Drugs to PRDM1-SLC22A16


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to PRDM1-SLC22A16


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource