UTHEALTH HOME    ABOUT SBMI    A-Z    WEBMAIL    INSIDE THE UNIVERSITY
FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact

Terms of Use
Center for Computational Systems Medicine level1
leaf

Fusion Gene Summary

leaf

Fusion Gene Sample Information

leaf

Fusion ORF Analysis

leaf

Fusion Amino Acid Sequences

leaf

Fusion Protein Functional Features

leaf

Fusion Protein-Protein Interaction

leaf

Related drugs with this fusion protein

leaf

Related disease with this fusion protein

Fusion Protein:PRDM2-PUM1

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: PRDM2-PUM1
FusionPDB ID: 68447
FusionGDB2.0 ID: 68447
HgeneTgene
Gene symbol

PRDM2

PUM1

Gene ID

7799

9698

Gene namePR/SET domain 2pumilio RNA binding family member 1
SynonymsHUMHOXY1|KMT8|KMT8A|MTB-ZF|RIZ|RIZ1|RIZ2HSPUM|PUMH|PUMH1|PUML1|SCA47
Cytomap

1p36.21

1p35.2

Type of geneprotein-codingprotein-coding
DescriptionPR domain zinc finger protein 2GATA-3 binding protein G3BMTE-binding proteinPR domain 2PR domain containing 2, with ZNF domainPR domain-containing protein 2lysine N-methyltransferase 8retinoblastoma protein-binding zinc finger proteinretinoblastompumilio homolog 1pumilio-1
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST idsENST00000502727, ENST00000235372, 
ENST00000311066, ENST00000376048, 
ENST00000343137, ENST00000413440, 
ENST00000503842, ENST00000505823, 
ENST00000257075, ENST00000373741, 
ENST00000373742, ENST00000373747, 
ENST00000423018, ENST00000424085, 
ENST00000426105, ENST00000440538, 
ENST00000490546, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score8 X 4 X 5=16012 X 12 X 5=720
# samples 713
** MAII scorelog2(7/160*10)=-1.1926450779424
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(13/720*10)=-2.46948528330122
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: PRDM2 [Title/Abstract] AND PUM1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)PRDM2(14075982)-PUM1(31426828), # samples:1
Anticipated loss of major functional domain due to fusion event.PRDM2-PUM1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
PRDM2-PUM1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
PRDM2-PUM1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
PRDM2-PUM1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgenePRDM2

GO:0045944

positive regulation of transcription by RNA polymerase II

8654390

TgenePUM1

GO:0010608

posttranscriptional regulation of gene expression

25100735

TgenePUM1

GO:0043488

regulation of mRNA stability

26724866

TgenePUM1

GO:0051726

regulation of cell cycle

20818387

TgenePUM1

GO:0051983

regulation of chromosome segregation

26724866

TgenePUM1

GO:1900246

positive regulation of RIG-I signaling pathway

25340845

TgenePUM1

GO:2000637

positive regulation of gene silencing by miRNA

20818387|22345517


check buttonFusion gene breakpoints across PRDM2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across PUM1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


Top

Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4ESCATCGA-IG-A7DPPRDM2chr1

14075982

+PUM1chr1

31426828

-


Top

Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000376048PRDM2chr114075982+ENST00000424085PUM1chr131426828-35806371201874584
ENST00000376048PRDM2chr114075982+ENST00000257075PUM1chr131426828-35806371201874584
ENST00000376048PRDM2chr114075982+ENST00000373747PUM1chr131426828-35866371201880586
ENST00000376048PRDM2chr114075982+ENST00000426105PUM1chr131426828-22666371201880586
ENST00000376048PRDM2chr114075982+ENST00000440538PUM1chr131426828-22486371201880586
ENST00000376048PRDM2chr114075982+ENST00000373741PUM1chr131426828-22426371201880586
ENST00000376048PRDM2chr114075982+ENST00000423018PUM1chr131426828-22296371201880586
ENST00000376048PRDM2chr114075982+ENST00000373742PUM1chr131426828-20066371201874584
ENST00000311066PRDM2chr114075982+ENST00000424085PUM1chr131426828-431013678502604584
ENST00000311066PRDM2chr114075982+ENST00000257075PUM1chr131426828-431013678502604584
ENST00000311066PRDM2chr114075982+ENST00000373747PUM1chr131426828-431613678502610586
ENST00000311066PRDM2chr114075982+ENST00000426105PUM1chr131426828-299613678502610586
ENST00000311066PRDM2chr114075982+ENST00000440538PUM1chr131426828-297813678502610586
ENST00000311066PRDM2chr114075982+ENST00000373741PUM1chr131426828-297213678502610586
ENST00000311066PRDM2chr114075982+ENST00000423018PUM1chr131426828-295913678502610586
ENST00000311066PRDM2chr114075982+ENST00000373742PUM1chr131426828-273613678502604584
ENST00000235372PRDM2chr114075982+ENST00000424085PUM1chr131426828-431013678502604584
ENST00000235372PRDM2chr114075982+ENST00000257075PUM1chr131426828-431013678502604584
ENST00000235372PRDM2chr114075982+ENST00000373747PUM1chr131426828-431613678502610586
ENST00000235372PRDM2chr114075982+ENST00000426105PUM1chr131426828-299613678502610586
ENST00000235372PRDM2chr114075982+ENST00000440538PUM1chr131426828-297813678502610586
ENST00000235372PRDM2chr114075982+ENST00000373741PUM1chr131426828-297213678502610586
ENST00000235372PRDM2chr114075982+ENST00000423018PUM1chr131426828-295913678502610586
ENST00000235372PRDM2chr114075982+ENST00000373742PUM1chr131426828-273613678502604584

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000376048ENST00000424085PRDM2chr114075982+PUM1chr131426828-0.0001524660.99984753
ENST00000376048ENST00000257075PRDM2chr114075982+PUM1chr131426828-0.0001524660.99984753
ENST00000376048ENST00000373747PRDM2chr114075982+PUM1chr131426828-0.0001423720.99985766
ENST00000376048ENST00000426105PRDM2chr114075982+PUM1chr131426828-0.000670670.9993293
ENST00000376048ENST00000440538PRDM2chr114075982+PUM1chr131426828-0.000761970.999238
ENST00000376048ENST00000373741PRDM2chr114075982+PUM1chr131426828-0.0007635380.99923646
ENST00000376048ENST00000423018PRDM2chr114075982+PUM1chr131426828-0.0008452820.9991547
ENST00000376048ENST00000373742PRDM2chr114075982+PUM1chr131426828-0.001891860.99810815
ENST00000311066ENST00000424085PRDM2chr114075982+PUM1chr131426828-0.0001408230.9998592
ENST00000311066ENST00000257075PRDM2chr114075982+PUM1chr131426828-0.0001408230.9998592
ENST00000311066ENST00000373747PRDM2chr114075982+PUM1chr131426828-0.0001346860.9998653
ENST00000311066ENST00000426105PRDM2chr114075982+PUM1chr131426828-0.0003279960.99967206
ENST00000311066ENST00000440538PRDM2chr114075982+PUM1chr131426828-0.0003657320.99963427
ENST00000311066ENST00000373741PRDM2chr114075982+PUM1chr131426828-0.0003674180.9996326
ENST00000311066ENST00000423018PRDM2chr114075982+PUM1chr131426828-0.0004038610.9995962
ENST00000311066ENST00000373742PRDM2chr114075982+PUM1chr131426828-0.0007095920.99929035
ENST00000235372ENST00000424085PRDM2chr114075982+PUM1chr131426828-0.0001408230.9998592
ENST00000235372ENST00000257075PRDM2chr114075982+PUM1chr131426828-0.0001408230.9998592
ENST00000235372ENST00000373747PRDM2chr114075982+PUM1chr131426828-0.0001346860.9998653
ENST00000235372ENST00000426105PRDM2chr114075982+PUM1chr131426828-0.0003279960.99967206
ENST00000235372ENST00000440538PRDM2chr114075982+PUM1chr131426828-0.0003657320.99963427
ENST00000235372ENST00000373741PRDM2chr114075982+PUM1chr131426828-0.0003674180.9996326
ENST00000235372ENST00000423018PRDM2chr114075982+PUM1chr131426828-0.0004038610.9995962
ENST00000235372ENST00000373742PRDM2chr114075982+PUM1chr131426828-0.0007095920.99929035

Top

Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>68447_68447_1_PRDM2-PUM1_PRDM2_chr1_14075982_ENST00000235372_PUM1_chr1_31426828_ENST00000257075_length(amino acids)=584AA_BP=172
MKMNQNTTEPVAATETLAEVPEHVLRGLPEEVRLFPSAVDKTRIGVWATKPILKGKKFGPFVGDKKKRSQVKNNVYMWEVYYPNLGWMCI
DATDPEKGNWLRYVNWACSGEEQNLFPLEINRAIYYKTLKPIAPGEELLVWYNGEDNPEIAAAIEEERASARSKRSSPKSRKGGLTNGSG
RYISAAPGAEAKYRSASSASSLFSPSSTLFSSSRLRYGMSDVMPSGRSRLLEDFRNNRYPNLQLREIAGHIMEFSQDQHGSRFIQLKLER
ATPAERQLVFNEILQAAYQLMVDVFGNYVIQKFFEFGSLEQKLALAERIRGHVLSLALQMYGCRVIQKALEFIPSDQQNEMVRELDGHVL
KCVKDQNGNHVVQKCIECVQPQSLQFIIDAFKGQVFALSTHPYGCRVIQRILEHCLPDQTLPILEELHQHTEQLVQDQYGNYVIQHVLEH
GRPEDKSKIVAEIRGNVLVLSQHKFASNVVEKCVTHASRTERAVLIDEVCTMNDGPHSALYTMMKDQYANYVVQKMIDVAEPGQRKIVMH

--------------------------------------------------------------

>68447_68447_2_PRDM2-PUM1_PRDM2_chr1_14075982_ENST00000235372_PUM1_chr1_31426828_ENST00000373741_length(amino acids)=586AA_BP=172
MKMNQNTTEPVAATETLAEVPEHVLRGLPEEVRLFPSAVDKTRIGVWATKPILKGKKFGPFVGDKKKRSQVKNNVYMWEVYYPNLGWMCI
DATDPEKGNWLRYVNWACSGEEQNLFPLEINRAIYYKTLKPIAPGEELLVWYNGEDNPEIAAAIEEERASARSKRSSPKSRKGGLTNGSG
RYISAAPGAEAKYRSASSASSLFSPSSTLFSSSRLRYGMSDVMPSGRSRLLEDFRNNRYPNLQLREIAGHIMEFSQDQHGSRFIQLKLER
ATPAERQLVFNEILQAAYQLMVDVFGNYVIQKFFEFGSLEQKLALAERIRGHVLSLALQMYGCRVIQKALEFIPSDQQVINEMVRELDGH
VLKCVKDQNGNHVVQKCIECVQPQSLQFIIDAFKGQVFALSTHPYGCRVIQRILEHCLPDQTLPILEELHQHTEQLVQDQYGNYVIQHVL
EHGRPEDKSKIVAEIRGNVLVLSQHKFASNVVEKCVTHASRTERAVLIDEVCTMNDGPHSALYTMMKDQYANYVVQKMIDVAEPGQRKIV

--------------------------------------------------------------

>68447_68447_3_PRDM2-PUM1_PRDM2_chr1_14075982_ENST00000235372_PUM1_chr1_31426828_ENST00000373742_length(amino acids)=584AA_BP=172
MKMNQNTTEPVAATETLAEVPEHVLRGLPEEVRLFPSAVDKTRIGVWATKPILKGKKFGPFVGDKKKRSQVKNNVYMWEVYYPNLGWMCI
DATDPEKGNWLRYVNWACSGEEQNLFPLEINRAIYYKTLKPIAPGEELLVWYNGEDNPEIAAAIEEERASARSKRSSPKSRKGGLTNGSG
RYISAAPGAEAKYRSASSASSLFSPSSTLFSSSRLRYGMSDVMPSGRSRLLEDFRNNRYPNLQLREIAGHIMEFSQDQHGSRFIQLKLER
ATPAERQLVFNEILQAAYQLMVDVFGNYVIQKFFEFGSLEQKLALAERIRGHVLSLALQMYGCRVIQKALEFIPSDQQNEMVRELDGHVL
KCVKDQNGNHVVQKCIECVQPQSLQFIIDAFKGQVFALSTHPYGCRVIQRILEHCLPDQTLPILEELHQHTEQLVQDQYGNYVIQHVLEH
GRPEDKSKIVAEIRGNVLVLSQHKFASNVVEKCVTHASRTERAVLIDEVCTMNDGPHSALYTMMKDQYANYVVQKMIDVAEPGQRKIVMH

--------------------------------------------------------------

>68447_68447_4_PRDM2-PUM1_PRDM2_chr1_14075982_ENST00000235372_PUM1_chr1_31426828_ENST00000373747_length(amino acids)=586AA_BP=172
MKMNQNTTEPVAATETLAEVPEHVLRGLPEEVRLFPSAVDKTRIGVWATKPILKGKKFGPFVGDKKKRSQVKNNVYMWEVYYPNLGWMCI
DATDPEKGNWLRYVNWACSGEEQNLFPLEINRAIYYKTLKPIAPGEELLVWYNGEDNPEIAAAIEEERASARSKRSSPKSRKGGLTNGSG
RYISAAPGAEAKYRSASSASSLFSPSSTLFSSSRLRYGMSDVMPSGRSRLLEDFRNNRYPNLQLREIAGHIMEFSQDQHGSRFIQLKLER
ATPAERQLVFNEILQAAYQLMVDVFGNYVIQKFFEFGSLEQKLALAERIRGHVLSLALQMYGCRVIQKALEFIPSDQQVINEMVRELDGH
VLKCVKDQNGNHVVQKCIECVQPQSLQFIIDAFKGQVFALSTHPYGCRVIQRILEHCLPDQTLPILEELHQHTEQLVQDQYGNYVIQHVL
EHGRPEDKSKIVAEIRGNVLVLSQHKFASNVVEKCVTHASRTERAVLIDEVCTMNDGPHSALYTMMKDQYANYVVQKMIDVAEPGQRKIV

--------------------------------------------------------------

>68447_68447_5_PRDM2-PUM1_PRDM2_chr1_14075982_ENST00000235372_PUM1_chr1_31426828_ENST00000423018_length(amino acids)=586AA_BP=172
MKMNQNTTEPVAATETLAEVPEHVLRGLPEEVRLFPSAVDKTRIGVWATKPILKGKKFGPFVGDKKKRSQVKNNVYMWEVYYPNLGWMCI
DATDPEKGNWLRYVNWACSGEEQNLFPLEINRAIYYKTLKPIAPGEELLVWYNGEDNPEIAAAIEEERASARSKRSSPKSRKGGLTNGSG
RYISAAPGAEAKYRSASSASSLFSPSSTLFSSSRLRYGMSDVMPSGRSRLLEDFRNNRYPNLQLREIAGHIMEFSQDQHGSRFIQLKLER
ATPAERQLVFNEILQAAYQLMVDVFGNYVIQKFFEFGSLEQKLALAERIRGHVLSLALQMYGCRVIQKALEFIPSDQQVINEMVRELDGH
VLKCVKDQNGNHVVQKCIECVQPQSLQFIIDAFKGQVFALSTHPYGCRVIQRILEHCLPDQTLPILEELHQHTEQLVQDQYGNYVIQHVL
EHGRPEDKSKIVAEIRGNVLVLSQHKFASNVVEKCVTHASRTERAVLIDEVCTMNDGPHSALYTMMKDQYANYVVQKMIDVAEPGQRKIV

--------------------------------------------------------------

>68447_68447_6_PRDM2-PUM1_PRDM2_chr1_14075982_ENST00000235372_PUM1_chr1_31426828_ENST00000424085_length(amino acids)=584AA_BP=172
MKMNQNTTEPVAATETLAEVPEHVLRGLPEEVRLFPSAVDKTRIGVWATKPILKGKKFGPFVGDKKKRSQVKNNVYMWEVYYPNLGWMCI
DATDPEKGNWLRYVNWACSGEEQNLFPLEINRAIYYKTLKPIAPGEELLVWYNGEDNPEIAAAIEEERASARSKRSSPKSRKGGLTNGSG
RYISAAPGAEAKYRSASSASSLFSPSSTLFSSSRLRYGMSDVMPSGRSRLLEDFRNNRYPNLQLREIAGHIMEFSQDQHGSRFIQLKLER
ATPAERQLVFNEILQAAYQLMVDVFGNYVIQKFFEFGSLEQKLALAERIRGHVLSLALQMYGCRVIQKALEFIPSDQQNEMVRELDGHVL
KCVKDQNGNHVVQKCIECVQPQSLQFIIDAFKGQVFALSTHPYGCRVIQRILEHCLPDQTLPILEELHQHTEQLVQDQYGNYVIQHVLEH
GRPEDKSKIVAEIRGNVLVLSQHKFASNVVEKCVTHASRTERAVLIDEVCTMNDGPHSALYTMMKDQYANYVVQKMIDVAEPGQRKIVMH

--------------------------------------------------------------

>68447_68447_7_PRDM2-PUM1_PRDM2_chr1_14075982_ENST00000235372_PUM1_chr1_31426828_ENST00000426105_length(amino acids)=586AA_BP=172
MKMNQNTTEPVAATETLAEVPEHVLRGLPEEVRLFPSAVDKTRIGVWATKPILKGKKFGPFVGDKKKRSQVKNNVYMWEVYYPNLGWMCI
DATDPEKGNWLRYVNWACSGEEQNLFPLEINRAIYYKTLKPIAPGEELLVWYNGEDNPEIAAAIEEERASARSKRSSPKSRKGGLTNGSG
RYISAAPGAEAKYRSASSASSLFSPSSTLFSSSRLRYGMSDVMPSGRSRLLEDFRNNRYPNLQLREIAGHIMEFSQDQHGSRFIQLKLER
ATPAERQLVFNEILQAAYQLMVDVFGNYVIQKFFEFGSLEQKLALAERIRGHVLSLALQMYGCRVIQKALEFIPSDQQVINEMVRELDGH
VLKCVKDQNGNHVVQKCIECVQPQSLQFIIDAFKGQVFALSTHPYGCRVIQRILEHCLPDQTLPILEELHQHTEQLVQDQYGNYVIQHVL
EHGRPEDKSKIVAEIRGNVLVLSQHKFASNVVEKCVTHASRTERAVLIDEVCTMNDGPHSALYTMMKDQYANYVVQKMIDVAEPGQRKIV

--------------------------------------------------------------

>68447_68447_8_PRDM2-PUM1_PRDM2_chr1_14075982_ENST00000235372_PUM1_chr1_31426828_ENST00000440538_length(amino acids)=586AA_BP=172
MKMNQNTTEPVAATETLAEVPEHVLRGLPEEVRLFPSAVDKTRIGVWATKPILKGKKFGPFVGDKKKRSQVKNNVYMWEVYYPNLGWMCI
DATDPEKGNWLRYVNWACSGEEQNLFPLEINRAIYYKTLKPIAPGEELLVWYNGEDNPEIAAAIEEERASARSKRSSPKSRKGGLTNGSG
RYISAAPGAEAKYRSASSASSLFSPSSTLFSSSRLRYGMSDVMPSGRSRLLEDFRNNRYPNLQLREIAGHIMEFSQDQHGSRFIQLKLER
ATPAERQLVFNEILQAAYQLMVDVFGNYVIQKFFEFGSLEQKLALAERIRGHVLSLALQMYGCRVIQKALEFIPSDQQVINEMVRELDGH
VLKCVKDQNGNHVVQKCIECVQPQSLQFIIDAFKGQVFALSTHPYGCRVIQRILEHCLPDQTLPILEELHQHTEQLVQDQYGNYVIQHVL
EHGRPEDKSKIVAEIRGNVLVLSQHKFASNVVEKCVTHASRTERAVLIDEVCTMNDGPHSALYTMMKDQYANYVVQKMIDVAEPGQRKIV

--------------------------------------------------------------

>68447_68447_9_PRDM2-PUM1_PRDM2_chr1_14075982_ENST00000311066_PUM1_chr1_31426828_ENST00000257075_length(amino acids)=584AA_BP=172
MKMNQNTTEPVAATETLAEVPEHVLRGLPEEVRLFPSAVDKTRIGVWATKPILKGKKFGPFVGDKKKRSQVKNNVYMWEVYYPNLGWMCI
DATDPEKGNWLRYVNWACSGEEQNLFPLEINRAIYYKTLKPIAPGEELLVWYNGEDNPEIAAAIEEERASARSKRSSPKSRKGGLTNGSG
RYISAAPGAEAKYRSASSASSLFSPSSTLFSSSRLRYGMSDVMPSGRSRLLEDFRNNRYPNLQLREIAGHIMEFSQDQHGSRFIQLKLER
ATPAERQLVFNEILQAAYQLMVDVFGNYVIQKFFEFGSLEQKLALAERIRGHVLSLALQMYGCRVIQKALEFIPSDQQNEMVRELDGHVL
KCVKDQNGNHVVQKCIECVQPQSLQFIIDAFKGQVFALSTHPYGCRVIQRILEHCLPDQTLPILEELHQHTEQLVQDQYGNYVIQHVLEH
GRPEDKSKIVAEIRGNVLVLSQHKFASNVVEKCVTHASRTERAVLIDEVCTMNDGPHSALYTMMKDQYANYVVQKMIDVAEPGQRKIVMH

--------------------------------------------------------------

>68447_68447_10_PRDM2-PUM1_PRDM2_chr1_14075982_ENST00000311066_PUM1_chr1_31426828_ENST00000373741_length(amino acids)=586AA_BP=172
MKMNQNTTEPVAATETLAEVPEHVLRGLPEEVRLFPSAVDKTRIGVWATKPILKGKKFGPFVGDKKKRSQVKNNVYMWEVYYPNLGWMCI
DATDPEKGNWLRYVNWACSGEEQNLFPLEINRAIYYKTLKPIAPGEELLVWYNGEDNPEIAAAIEEERASARSKRSSPKSRKGGLTNGSG
RYISAAPGAEAKYRSASSASSLFSPSSTLFSSSRLRYGMSDVMPSGRSRLLEDFRNNRYPNLQLREIAGHIMEFSQDQHGSRFIQLKLER
ATPAERQLVFNEILQAAYQLMVDVFGNYVIQKFFEFGSLEQKLALAERIRGHVLSLALQMYGCRVIQKALEFIPSDQQVINEMVRELDGH
VLKCVKDQNGNHVVQKCIECVQPQSLQFIIDAFKGQVFALSTHPYGCRVIQRILEHCLPDQTLPILEELHQHTEQLVQDQYGNYVIQHVL
EHGRPEDKSKIVAEIRGNVLVLSQHKFASNVVEKCVTHASRTERAVLIDEVCTMNDGPHSALYTMMKDQYANYVVQKMIDVAEPGQRKIV

--------------------------------------------------------------

>68447_68447_11_PRDM2-PUM1_PRDM2_chr1_14075982_ENST00000311066_PUM1_chr1_31426828_ENST00000373742_length(amino acids)=584AA_BP=172
MKMNQNTTEPVAATETLAEVPEHVLRGLPEEVRLFPSAVDKTRIGVWATKPILKGKKFGPFVGDKKKRSQVKNNVYMWEVYYPNLGWMCI
DATDPEKGNWLRYVNWACSGEEQNLFPLEINRAIYYKTLKPIAPGEELLVWYNGEDNPEIAAAIEEERASARSKRSSPKSRKGGLTNGSG
RYISAAPGAEAKYRSASSASSLFSPSSTLFSSSRLRYGMSDVMPSGRSRLLEDFRNNRYPNLQLREIAGHIMEFSQDQHGSRFIQLKLER
ATPAERQLVFNEILQAAYQLMVDVFGNYVIQKFFEFGSLEQKLALAERIRGHVLSLALQMYGCRVIQKALEFIPSDQQNEMVRELDGHVL
KCVKDQNGNHVVQKCIECVQPQSLQFIIDAFKGQVFALSTHPYGCRVIQRILEHCLPDQTLPILEELHQHTEQLVQDQYGNYVIQHVLEH
GRPEDKSKIVAEIRGNVLVLSQHKFASNVVEKCVTHASRTERAVLIDEVCTMNDGPHSALYTMMKDQYANYVVQKMIDVAEPGQRKIVMH

--------------------------------------------------------------

>68447_68447_12_PRDM2-PUM1_PRDM2_chr1_14075982_ENST00000311066_PUM1_chr1_31426828_ENST00000373747_length(amino acids)=586AA_BP=172
MKMNQNTTEPVAATETLAEVPEHVLRGLPEEVRLFPSAVDKTRIGVWATKPILKGKKFGPFVGDKKKRSQVKNNVYMWEVYYPNLGWMCI
DATDPEKGNWLRYVNWACSGEEQNLFPLEINRAIYYKTLKPIAPGEELLVWYNGEDNPEIAAAIEEERASARSKRSSPKSRKGGLTNGSG
RYISAAPGAEAKYRSASSASSLFSPSSTLFSSSRLRYGMSDVMPSGRSRLLEDFRNNRYPNLQLREIAGHIMEFSQDQHGSRFIQLKLER
ATPAERQLVFNEILQAAYQLMVDVFGNYVIQKFFEFGSLEQKLALAERIRGHVLSLALQMYGCRVIQKALEFIPSDQQVINEMVRELDGH
VLKCVKDQNGNHVVQKCIECVQPQSLQFIIDAFKGQVFALSTHPYGCRVIQRILEHCLPDQTLPILEELHQHTEQLVQDQYGNYVIQHVL
EHGRPEDKSKIVAEIRGNVLVLSQHKFASNVVEKCVTHASRTERAVLIDEVCTMNDGPHSALYTMMKDQYANYVVQKMIDVAEPGQRKIV

--------------------------------------------------------------

>68447_68447_13_PRDM2-PUM1_PRDM2_chr1_14075982_ENST00000311066_PUM1_chr1_31426828_ENST00000423018_length(amino acids)=586AA_BP=172
MKMNQNTTEPVAATETLAEVPEHVLRGLPEEVRLFPSAVDKTRIGVWATKPILKGKKFGPFVGDKKKRSQVKNNVYMWEVYYPNLGWMCI
DATDPEKGNWLRYVNWACSGEEQNLFPLEINRAIYYKTLKPIAPGEELLVWYNGEDNPEIAAAIEEERASARSKRSSPKSRKGGLTNGSG
RYISAAPGAEAKYRSASSASSLFSPSSTLFSSSRLRYGMSDVMPSGRSRLLEDFRNNRYPNLQLREIAGHIMEFSQDQHGSRFIQLKLER
ATPAERQLVFNEILQAAYQLMVDVFGNYVIQKFFEFGSLEQKLALAERIRGHVLSLALQMYGCRVIQKALEFIPSDQQVINEMVRELDGH
VLKCVKDQNGNHVVQKCIECVQPQSLQFIIDAFKGQVFALSTHPYGCRVIQRILEHCLPDQTLPILEELHQHTEQLVQDQYGNYVIQHVL
EHGRPEDKSKIVAEIRGNVLVLSQHKFASNVVEKCVTHASRTERAVLIDEVCTMNDGPHSALYTMMKDQYANYVVQKMIDVAEPGQRKIV

--------------------------------------------------------------

>68447_68447_14_PRDM2-PUM1_PRDM2_chr1_14075982_ENST00000311066_PUM1_chr1_31426828_ENST00000424085_length(amino acids)=584AA_BP=172
MKMNQNTTEPVAATETLAEVPEHVLRGLPEEVRLFPSAVDKTRIGVWATKPILKGKKFGPFVGDKKKRSQVKNNVYMWEVYYPNLGWMCI
DATDPEKGNWLRYVNWACSGEEQNLFPLEINRAIYYKTLKPIAPGEELLVWYNGEDNPEIAAAIEEERASARSKRSSPKSRKGGLTNGSG
RYISAAPGAEAKYRSASSASSLFSPSSTLFSSSRLRYGMSDVMPSGRSRLLEDFRNNRYPNLQLREIAGHIMEFSQDQHGSRFIQLKLER
ATPAERQLVFNEILQAAYQLMVDVFGNYVIQKFFEFGSLEQKLALAERIRGHVLSLALQMYGCRVIQKALEFIPSDQQNEMVRELDGHVL
KCVKDQNGNHVVQKCIECVQPQSLQFIIDAFKGQVFALSTHPYGCRVIQRILEHCLPDQTLPILEELHQHTEQLVQDQYGNYVIQHVLEH
GRPEDKSKIVAEIRGNVLVLSQHKFASNVVEKCVTHASRTERAVLIDEVCTMNDGPHSALYTMMKDQYANYVVQKMIDVAEPGQRKIVMH

--------------------------------------------------------------

>68447_68447_15_PRDM2-PUM1_PRDM2_chr1_14075982_ENST00000311066_PUM1_chr1_31426828_ENST00000426105_length(amino acids)=586AA_BP=172
MKMNQNTTEPVAATETLAEVPEHVLRGLPEEVRLFPSAVDKTRIGVWATKPILKGKKFGPFVGDKKKRSQVKNNVYMWEVYYPNLGWMCI
DATDPEKGNWLRYVNWACSGEEQNLFPLEINRAIYYKTLKPIAPGEELLVWYNGEDNPEIAAAIEEERASARSKRSSPKSRKGGLTNGSG
RYISAAPGAEAKYRSASSASSLFSPSSTLFSSSRLRYGMSDVMPSGRSRLLEDFRNNRYPNLQLREIAGHIMEFSQDQHGSRFIQLKLER
ATPAERQLVFNEILQAAYQLMVDVFGNYVIQKFFEFGSLEQKLALAERIRGHVLSLALQMYGCRVIQKALEFIPSDQQVINEMVRELDGH
VLKCVKDQNGNHVVQKCIECVQPQSLQFIIDAFKGQVFALSTHPYGCRVIQRILEHCLPDQTLPILEELHQHTEQLVQDQYGNYVIQHVL
EHGRPEDKSKIVAEIRGNVLVLSQHKFASNVVEKCVTHASRTERAVLIDEVCTMNDGPHSALYTMMKDQYANYVVQKMIDVAEPGQRKIV

--------------------------------------------------------------

>68447_68447_16_PRDM2-PUM1_PRDM2_chr1_14075982_ENST00000311066_PUM1_chr1_31426828_ENST00000440538_length(amino acids)=586AA_BP=172
MKMNQNTTEPVAATETLAEVPEHVLRGLPEEVRLFPSAVDKTRIGVWATKPILKGKKFGPFVGDKKKRSQVKNNVYMWEVYYPNLGWMCI
DATDPEKGNWLRYVNWACSGEEQNLFPLEINRAIYYKTLKPIAPGEELLVWYNGEDNPEIAAAIEEERASARSKRSSPKSRKGGLTNGSG
RYISAAPGAEAKYRSASSASSLFSPSSTLFSSSRLRYGMSDVMPSGRSRLLEDFRNNRYPNLQLREIAGHIMEFSQDQHGSRFIQLKLER
ATPAERQLVFNEILQAAYQLMVDVFGNYVIQKFFEFGSLEQKLALAERIRGHVLSLALQMYGCRVIQKALEFIPSDQQVINEMVRELDGH
VLKCVKDQNGNHVVQKCIECVQPQSLQFIIDAFKGQVFALSTHPYGCRVIQRILEHCLPDQTLPILEELHQHTEQLVQDQYGNYVIQHVL
EHGRPEDKSKIVAEIRGNVLVLSQHKFASNVVEKCVTHASRTERAVLIDEVCTMNDGPHSALYTMMKDQYANYVVQKMIDVAEPGQRKIV

--------------------------------------------------------------

>68447_68447_17_PRDM2-PUM1_PRDM2_chr1_14075982_ENST00000376048_PUM1_chr1_31426828_ENST00000257075_length(amino acids)=584AA_BP=172
MKMNQNTTEPVAATETLAEVPEHVLRGLPEEVRLFPSAVDKTRIGVWATKPILKGKKFGPFVGDKKKRSQVKNNVYMWEVYYPNLGWMCI
DATDPEKGNWLRYVNWACSGEEQNLFPLEINRAIYYKTLKPIAPGEELLVWYNGEDNPEIAAAIEEERASARSKRSSPKSRKGGLTNGSG
RYISAAPGAEAKYRSASSASSLFSPSSTLFSSSRLRYGMSDVMPSGRSRLLEDFRNNRYPNLQLREIAGHIMEFSQDQHGSRFIQLKLER
ATPAERQLVFNEILQAAYQLMVDVFGNYVIQKFFEFGSLEQKLALAERIRGHVLSLALQMYGCRVIQKALEFIPSDQQNEMVRELDGHVL
KCVKDQNGNHVVQKCIECVQPQSLQFIIDAFKGQVFALSTHPYGCRVIQRILEHCLPDQTLPILEELHQHTEQLVQDQYGNYVIQHVLEH
GRPEDKSKIVAEIRGNVLVLSQHKFASNVVEKCVTHASRTERAVLIDEVCTMNDGPHSALYTMMKDQYANYVVQKMIDVAEPGQRKIVMH

--------------------------------------------------------------

>68447_68447_18_PRDM2-PUM1_PRDM2_chr1_14075982_ENST00000376048_PUM1_chr1_31426828_ENST00000373741_length(amino acids)=586AA_BP=172
MKMNQNTTEPVAATETLAEVPEHVLRGLPEEVRLFPSAVDKTRIGVWATKPILKGKKFGPFVGDKKKRSQVKNNVYMWEVYYPNLGWMCI
DATDPEKGNWLRYVNWACSGEEQNLFPLEINRAIYYKTLKPIAPGEELLVWYNGEDNPEIAAAIEEERASARSKRSSPKSRKGGLTNGSG
RYISAAPGAEAKYRSASSASSLFSPSSTLFSSSRLRYGMSDVMPSGRSRLLEDFRNNRYPNLQLREIAGHIMEFSQDQHGSRFIQLKLER
ATPAERQLVFNEILQAAYQLMVDVFGNYVIQKFFEFGSLEQKLALAERIRGHVLSLALQMYGCRVIQKALEFIPSDQQVINEMVRELDGH
VLKCVKDQNGNHVVQKCIECVQPQSLQFIIDAFKGQVFALSTHPYGCRVIQRILEHCLPDQTLPILEELHQHTEQLVQDQYGNYVIQHVL
EHGRPEDKSKIVAEIRGNVLVLSQHKFASNVVEKCVTHASRTERAVLIDEVCTMNDGPHSALYTMMKDQYANYVVQKMIDVAEPGQRKIV

--------------------------------------------------------------

>68447_68447_19_PRDM2-PUM1_PRDM2_chr1_14075982_ENST00000376048_PUM1_chr1_31426828_ENST00000373742_length(amino acids)=584AA_BP=172
MKMNQNTTEPVAATETLAEVPEHVLRGLPEEVRLFPSAVDKTRIGVWATKPILKGKKFGPFVGDKKKRSQVKNNVYMWEVYYPNLGWMCI
DATDPEKGNWLRYVNWACSGEEQNLFPLEINRAIYYKTLKPIAPGEELLVWYNGEDNPEIAAAIEEERASARSKRSSPKSRKGGLTNGSG
RYISAAPGAEAKYRSASSASSLFSPSSTLFSSSRLRYGMSDVMPSGRSRLLEDFRNNRYPNLQLREIAGHIMEFSQDQHGSRFIQLKLER
ATPAERQLVFNEILQAAYQLMVDVFGNYVIQKFFEFGSLEQKLALAERIRGHVLSLALQMYGCRVIQKALEFIPSDQQNEMVRELDGHVL
KCVKDQNGNHVVQKCIECVQPQSLQFIIDAFKGQVFALSTHPYGCRVIQRILEHCLPDQTLPILEELHQHTEQLVQDQYGNYVIQHVLEH
GRPEDKSKIVAEIRGNVLVLSQHKFASNVVEKCVTHASRTERAVLIDEVCTMNDGPHSALYTMMKDQYANYVVQKMIDVAEPGQRKIVMH

--------------------------------------------------------------

>68447_68447_20_PRDM2-PUM1_PRDM2_chr1_14075982_ENST00000376048_PUM1_chr1_31426828_ENST00000373747_length(amino acids)=586AA_BP=172
MKMNQNTTEPVAATETLAEVPEHVLRGLPEEVRLFPSAVDKTRIGVWATKPILKGKKFGPFVGDKKKRSQVKNNVYMWEVYYPNLGWMCI
DATDPEKGNWLRYVNWACSGEEQNLFPLEINRAIYYKTLKPIAPGEELLVWYNGEDNPEIAAAIEEERASARSKRSSPKSRKGGLTNGSG
RYISAAPGAEAKYRSASSASSLFSPSSTLFSSSRLRYGMSDVMPSGRSRLLEDFRNNRYPNLQLREIAGHIMEFSQDQHGSRFIQLKLER
ATPAERQLVFNEILQAAYQLMVDVFGNYVIQKFFEFGSLEQKLALAERIRGHVLSLALQMYGCRVIQKALEFIPSDQQVINEMVRELDGH
VLKCVKDQNGNHVVQKCIECVQPQSLQFIIDAFKGQVFALSTHPYGCRVIQRILEHCLPDQTLPILEELHQHTEQLVQDQYGNYVIQHVL
EHGRPEDKSKIVAEIRGNVLVLSQHKFASNVVEKCVTHASRTERAVLIDEVCTMNDGPHSALYTMMKDQYANYVVQKMIDVAEPGQRKIV

--------------------------------------------------------------

>68447_68447_21_PRDM2-PUM1_PRDM2_chr1_14075982_ENST00000376048_PUM1_chr1_31426828_ENST00000423018_length(amino acids)=586AA_BP=172
MKMNQNTTEPVAATETLAEVPEHVLRGLPEEVRLFPSAVDKTRIGVWATKPILKGKKFGPFVGDKKKRSQVKNNVYMWEVYYPNLGWMCI
DATDPEKGNWLRYVNWACSGEEQNLFPLEINRAIYYKTLKPIAPGEELLVWYNGEDNPEIAAAIEEERASARSKRSSPKSRKGGLTNGSG
RYISAAPGAEAKYRSASSASSLFSPSSTLFSSSRLRYGMSDVMPSGRSRLLEDFRNNRYPNLQLREIAGHIMEFSQDQHGSRFIQLKLER
ATPAERQLVFNEILQAAYQLMVDVFGNYVIQKFFEFGSLEQKLALAERIRGHVLSLALQMYGCRVIQKALEFIPSDQQVINEMVRELDGH
VLKCVKDQNGNHVVQKCIECVQPQSLQFIIDAFKGQVFALSTHPYGCRVIQRILEHCLPDQTLPILEELHQHTEQLVQDQYGNYVIQHVL
EHGRPEDKSKIVAEIRGNVLVLSQHKFASNVVEKCVTHASRTERAVLIDEVCTMNDGPHSALYTMMKDQYANYVVQKMIDVAEPGQRKIV

--------------------------------------------------------------

>68447_68447_22_PRDM2-PUM1_PRDM2_chr1_14075982_ENST00000376048_PUM1_chr1_31426828_ENST00000424085_length(amino acids)=584AA_BP=172
MKMNQNTTEPVAATETLAEVPEHVLRGLPEEVRLFPSAVDKTRIGVWATKPILKGKKFGPFVGDKKKRSQVKNNVYMWEVYYPNLGWMCI
DATDPEKGNWLRYVNWACSGEEQNLFPLEINRAIYYKTLKPIAPGEELLVWYNGEDNPEIAAAIEEERASARSKRSSPKSRKGGLTNGSG
RYISAAPGAEAKYRSASSASSLFSPSSTLFSSSRLRYGMSDVMPSGRSRLLEDFRNNRYPNLQLREIAGHIMEFSQDQHGSRFIQLKLER
ATPAERQLVFNEILQAAYQLMVDVFGNYVIQKFFEFGSLEQKLALAERIRGHVLSLALQMYGCRVIQKALEFIPSDQQNEMVRELDGHVL
KCVKDQNGNHVVQKCIECVQPQSLQFIIDAFKGQVFALSTHPYGCRVIQRILEHCLPDQTLPILEELHQHTEQLVQDQYGNYVIQHVLEH
GRPEDKSKIVAEIRGNVLVLSQHKFASNVVEKCVTHASRTERAVLIDEVCTMNDGPHSALYTMMKDQYANYVVQKMIDVAEPGQRKIVMH

--------------------------------------------------------------

>68447_68447_23_PRDM2-PUM1_PRDM2_chr1_14075982_ENST00000376048_PUM1_chr1_31426828_ENST00000426105_length(amino acids)=586AA_BP=172
MKMNQNTTEPVAATETLAEVPEHVLRGLPEEVRLFPSAVDKTRIGVWATKPILKGKKFGPFVGDKKKRSQVKNNVYMWEVYYPNLGWMCI
DATDPEKGNWLRYVNWACSGEEQNLFPLEINRAIYYKTLKPIAPGEELLVWYNGEDNPEIAAAIEEERASARSKRSSPKSRKGGLTNGSG
RYISAAPGAEAKYRSASSASSLFSPSSTLFSSSRLRYGMSDVMPSGRSRLLEDFRNNRYPNLQLREIAGHIMEFSQDQHGSRFIQLKLER
ATPAERQLVFNEILQAAYQLMVDVFGNYVIQKFFEFGSLEQKLALAERIRGHVLSLALQMYGCRVIQKALEFIPSDQQVINEMVRELDGH
VLKCVKDQNGNHVVQKCIECVQPQSLQFIIDAFKGQVFALSTHPYGCRVIQRILEHCLPDQTLPILEELHQHTEQLVQDQYGNYVIQHVL
EHGRPEDKSKIVAEIRGNVLVLSQHKFASNVVEKCVTHASRTERAVLIDEVCTMNDGPHSALYTMMKDQYANYVVQKMIDVAEPGQRKIV

--------------------------------------------------------------

>68447_68447_24_PRDM2-PUM1_PRDM2_chr1_14075982_ENST00000376048_PUM1_chr1_31426828_ENST00000440538_length(amino acids)=586AA_BP=172
MKMNQNTTEPVAATETLAEVPEHVLRGLPEEVRLFPSAVDKTRIGVWATKPILKGKKFGPFVGDKKKRSQVKNNVYMWEVYYPNLGWMCI
DATDPEKGNWLRYVNWACSGEEQNLFPLEINRAIYYKTLKPIAPGEELLVWYNGEDNPEIAAAIEEERASARSKRSSPKSRKGGLTNGSG
RYISAAPGAEAKYRSASSASSLFSPSSTLFSSSRLRYGMSDVMPSGRSRLLEDFRNNRYPNLQLREIAGHIMEFSQDQHGSRFIQLKLER
ATPAERQLVFNEILQAAYQLMVDVFGNYVIQKFFEFGSLEQKLALAERIRGHVLSLALQMYGCRVIQKALEFIPSDQQVINEMVRELDGH
VLKCVKDQNGNHVVQKCIECVQPQSLQFIIDAFKGQVFALSTHPYGCRVIQRILEHCLPDQTLPILEELHQHTEQLVQDQYGNYVIQHVL
EHGRPEDKSKIVAEIRGNVLVLSQHKFASNVVEKCVTHASRTERAVLIDEVCTMNDGPHSALYTMMKDQYANYVVQKMIDVAEPGQRKIV

--------------------------------------------------------------

Top

Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr1:14075982/chr1:31426828)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePRDM2chr1:14075982chr1:31426828ENST00000235372+61028_141170.333333333333342095.6666666666665DomainSET
HgenePRDM2chr1:14075982chr1:31426828ENST00000311066+6928_141170.333333333333341683.0DomainSET
HgenePRDM2chr1:14075982chr1:31426828ENST00000376048+6828_141170.33333333333334227.0DomainSET
TgenePUM1chr1:14075982chr1:31426828ENST000002570751322828_1168774.33333333333341187.0DomainPUM-HD
TgenePUM1chr1:14075982chr1:31426828ENST000004261051322828_1168774.33333333333341189.0DomainPUM-HD
TgenePUM1chr1:14075982chr1:31426828ENST000004405381322828_1168748.33333333333341163.0DomainPUM-HD
TgenePUM1chr1:14075982chr1:31426828ENST0000025707513221028_1063774.33333333333341187.0RepeatPumilio 6
TgenePUM1chr1:14075982chr1:31426828ENST0000025707513221064_1099774.33333333333341187.0RepeatPumilio 7
TgenePUM1chr1:14075982chr1:31426828ENST0000025707513221103_1142774.33333333333341187.0RepeatPumilio 8
TgenePUM1chr1:14075982chr1:31426828ENST000002570751322848_883774.33333333333341187.0RepeatPumilio 1
TgenePUM1chr1:14075982chr1:31426828ENST000002570751322884_919774.33333333333341187.0RepeatPumilio 2
TgenePUM1chr1:14075982chr1:31426828ENST000002570751322920_955774.33333333333341187.0RepeatPumilio 3
TgenePUM1chr1:14075982chr1:31426828ENST000002570751322956_991774.33333333333341187.0RepeatPumilio 4
TgenePUM1chr1:14075982chr1:31426828ENST000002570751322992_1027774.33333333333341187.0RepeatPumilio 5
TgenePUM1chr1:14075982chr1:31426828ENST0000042610513221028_1063774.33333333333341189.0RepeatPumilio 6
TgenePUM1chr1:14075982chr1:31426828ENST0000042610513221064_1099774.33333333333341189.0RepeatPumilio 7
TgenePUM1chr1:14075982chr1:31426828ENST0000042610513221103_1142774.33333333333341189.0RepeatPumilio 8
TgenePUM1chr1:14075982chr1:31426828ENST000004261051322848_883774.33333333333341189.0RepeatPumilio 1
TgenePUM1chr1:14075982chr1:31426828ENST000004261051322884_919774.33333333333341189.0RepeatPumilio 2
TgenePUM1chr1:14075982chr1:31426828ENST000004261051322920_955774.33333333333341189.0RepeatPumilio 3
TgenePUM1chr1:14075982chr1:31426828ENST000004261051322956_991774.33333333333341189.0RepeatPumilio 4
TgenePUM1chr1:14075982chr1:31426828ENST000004261051322992_1027774.33333333333341189.0RepeatPumilio 5
TgenePUM1chr1:14075982chr1:31426828ENST0000044053813221028_1063748.33333333333341163.0RepeatPumilio 6
TgenePUM1chr1:14075982chr1:31426828ENST0000044053813221064_1099748.33333333333341163.0RepeatPumilio 7
TgenePUM1chr1:14075982chr1:31426828ENST0000044053813221103_1142748.33333333333341163.0RepeatPumilio 8
TgenePUM1chr1:14075982chr1:31426828ENST000004405381322848_883748.33333333333341163.0RepeatPumilio 1
TgenePUM1chr1:14075982chr1:31426828ENST000004405381322884_919748.33333333333341163.0RepeatPumilio 2
TgenePUM1chr1:14075982chr1:31426828ENST000004405381322920_955748.33333333333341163.0RepeatPumilio 3
TgenePUM1chr1:14075982chr1:31426828ENST000004405381322956_991748.33333333333341163.0RepeatPumilio 4
TgenePUM1chr1:14075982chr1:31426828ENST000004405381322992_1027748.33333333333341163.0RepeatPumilio 5

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePRDM2chr1:14075982chr1:31426828ENST00000235372+6101052_1074170.333333333333342095.6666666666665Compositional biasNote=Poly-Ser
HgenePRDM2chr1:14075982chr1:31426828ENST00000235372+6101361_1447170.333333333333342095.6666666666665Compositional biasNote=Arg/Lys-rich (basic)
HgenePRDM2chr1:14075982chr1:31426828ENST00000235372+610268_296170.333333333333342095.6666666666665Compositional biasNote=Asp/Glu-rich (acidic)
HgenePRDM2chr1:14075982chr1:31426828ENST00000235372+610933_1049170.333333333333342095.6666666666665Compositional biasNote=Pro-rich
HgenePRDM2chr1:14075982chr1:31426828ENST00000311066+691052_1074170.333333333333341683.0Compositional biasNote=Poly-Ser
HgenePRDM2chr1:14075982chr1:31426828ENST00000311066+691361_1447170.333333333333341683.0Compositional biasNote=Arg/Lys-rich (basic)
HgenePRDM2chr1:14075982chr1:31426828ENST00000311066+69268_296170.333333333333341683.0Compositional biasNote=Asp/Glu-rich (acidic)
HgenePRDM2chr1:14075982chr1:31426828ENST00000311066+69933_1049170.333333333333341683.0Compositional biasNote=Pro-rich
HgenePRDM2chr1:14075982chr1:31426828ENST00000376048+681052_1074170.33333333333334227.0Compositional biasNote=Poly-Ser
HgenePRDM2chr1:14075982chr1:31426828ENST00000376048+681361_1447170.33333333333334227.0Compositional biasNote=Arg/Lys-rich (basic)
HgenePRDM2chr1:14075982chr1:31426828ENST00000376048+68268_296170.33333333333334227.0Compositional biasNote=Asp/Glu-rich (acidic)
HgenePRDM2chr1:14075982chr1:31426828ENST00000376048+68933_1049170.33333333333334227.0Compositional biasNote=Pro-rich
HgenePRDM2chr1:14075982chr1:31426828ENST00000235372+6101028_1052170.333333333333342095.6666666666665MotifSH3-binding
HgenePRDM2chr1:14075982chr1:31426828ENST00000235372+610970_979170.333333333333342095.6666666666665MotifSH3-binding
HgenePRDM2chr1:14075982chr1:31426828ENST00000235372+610985_998170.333333333333342095.6666666666665MotifSH3-binding
HgenePRDM2chr1:14075982chr1:31426828ENST00000311066+691028_1052170.333333333333341683.0MotifSH3-binding
HgenePRDM2chr1:14075982chr1:31426828ENST00000311066+69970_979170.333333333333341683.0MotifSH3-binding
HgenePRDM2chr1:14075982chr1:31426828ENST00000311066+69985_998170.333333333333341683.0MotifSH3-binding
HgenePRDM2chr1:14075982chr1:31426828ENST00000376048+681028_1052170.33333333333334227.0MotifSH3-binding
HgenePRDM2chr1:14075982chr1:31426828ENST00000376048+68970_979170.33333333333334227.0MotifSH3-binding
HgenePRDM2chr1:14075982chr1:31426828ENST00000376048+68985_998170.33333333333334227.0MotifSH3-binding
HgenePRDM2chr1:14075982chr1:31426828ENST00000235372+610294_316170.333333333333342095.6666666666665RegionNote=Retinoblastoma protein binding
HgenePRDM2chr1:14075982chr1:31426828ENST00000311066+69294_316170.333333333333341683.0RegionNote=Retinoblastoma protein binding
HgenePRDM2chr1:14075982chr1:31426828ENST00000376048+68294_316170.33333333333334227.0RegionNote=Retinoblastoma protein binding
HgenePRDM2chr1:14075982chr1:31426828ENST00000235372+6101134_1156170.333333333333342095.6666666666665Zinc fingerC2H2-type 4
HgenePRDM2chr1:14075982chr1:31426828ENST00000235372+6101162_1185170.333333333333342095.6666666666665Zinc fingerC2H2-type 5
HgenePRDM2chr1:14075982chr1:31426828ENST00000235372+6101191_1214170.333333333333342095.6666666666665Zinc fingerC2H2-type 6
HgenePRDM2chr1:14075982chr1:31426828ENST00000235372+6101333_1355170.333333333333342095.6666666666665Zinc fingerC2H2-type 7%3B atypical
HgenePRDM2chr1:14075982chr1:31426828ENST00000235372+6101455_1478170.333333333333342095.6666666666665Zinc fingerC2H2-type 8%3B atypical
HgenePRDM2chr1:14075982chr1:31426828ENST00000235372+610360_382170.333333333333342095.6666666666665Zinc fingerC2H2-type 1
HgenePRDM2chr1:14075982chr1:31426828ENST00000235372+610390_412170.333333333333342095.6666666666665Zinc fingerC2H2-type 2
HgenePRDM2chr1:14075982chr1:31426828ENST00000235372+610483_506170.333333333333342095.6666666666665Zinc fingerC2H2-type 3
HgenePRDM2chr1:14075982chr1:31426828ENST00000311066+691134_1156170.333333333333341683.0Zinc fingerC2H2-type 4
HgenePRDM2chr1:14075982chr1:31426828ENST00000311066+691162_1185170.333333333333341683.0Zinc fingerC2H2-type 5
HgenePRDM2chr1:14075982chr1:31426828ENST00000311066+691191_1214170.333333333333341683.0Zinc fingerC2H2-type 6
HgenePRDM2chr1:14075982chr1:31426828ENST00000311066+691333_1355170.333333333333341683.0Zinc fingerC2H2-type 7%3B atypical
HgenePRDM2chr1:14075982chr1:31426828ENST00000311066+691455_1478170.333333333333341683.0Zinc fingerC2H2-type 8%3B atypical
HgenePRDM2chr1:14075982chr1:31426828ENST00000311066+69360_382170.333333333333341683.0Zinc fingerC2H2-type 1
HgenePRDM2chr1:14075982chr1:31426828ENST00000311066+69390_412170.333333333333341683.0Zinc fingerC2H2-type 2
HgenePRDM2chr1:14075982chr1:31426828ENST00000311066+69483_506170.333333333333341683.0Zinc fingerC2H2-type 3
HgenePRDM2chr1:14075982chr1:31426828ENST00000376048+681134_1156170.33333333333334227.0Zinc fingerC2H2-type 4
HgenePRDM2chr1:14075982chr1:31426828ENST00000376048+681162_1185170.33333333333334227.0Zinc fingerC2H2-type 5
HgenePRDM2chr1:14075982chr1:31426828ENST00000376048+681191_1214170.33333333333334227.0Zinc fingerC2H2-type 6
HgenePRDM2chr1:14075982chr1:31426828ENST00000376048+681333_1355170.33333333333334227.0Zinc fingerC2H2-type 7%3B atypical
HgenePRDM2chr1:14075982chr1:31426828ENST00000376048+681455_1478170.33333333333334227.0Zinc fingerC2H2-type 8%3B atypical
HgenePRDM2chr1:14075982chr1:31426828ENST00000376048+68360_382170.33333333333334227.0Zinc fingerC2H2-type 1
HgenePRDM2chr1:14075982chr1:31426828ENST00000376048+68390_412170.33333333333334227.0Zinc fingerC2H2-type 2
HgenePRDM2chr1:14075982chr1:31426828ENST00000376048+68483_506170.33333333333334227.0Zinc fingerC2H2-type 3
TgenePUM1chr1:14075982chr1:31426828ENST000002570751322393_613774.33333333333341187.0Compositional biasNote=Ala-rich
TgenePUM1chr1:14075982chr1:31426828ENST000002570751322475_523774.33333333333341187.0Compositional biasNote=Gln-rich
TgenePUM1chr1:14075982chr1:31426828ENST000002570751322642_815774.33333333333341187.0Compositional biasNote=Ser-rich
TgenePUM1chr1:14075982chr1:31426828ENST000004261051322393_613774.33333333333341189.0Compositional biasNote=Ala-rich
TgenePUM1chr1:14075982chr1:31426828ENST000004261051322475_523774.33333333333341189.0Compositional biasNote=Gln-rich
TgenePUM1chr1:14075982chr1:31426828ENST000004261051322642_815774.33333333333341189.0Compositional biasNote=Ser-rich
TgenePUM1chr1:14075982chr1:31426828ENST000004405381322393_613748.33333333333341163.0Compositional biasNote=Ala-rich
TgenePUM1chr1:14075982chr1:31426828ENST000004405381322475_523748.33333333333341163.0Compositional biasNote=Gln-rich
TgenePUM1chr1:14075982chr1:31426828ENST000004405381322642_815748.33333333333341163.0Compositional biasNote=Ser-rich


Top

Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
PRDM2
PUM1


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

Related Drugs to PRDM2-PUM1


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

Top

Related Diseases to PRDM2-PUM1


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource