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Center for Computational Systems Medicine level1
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:ARRDC1-EHMT1

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: ARRDC1-EHMT1
FusionPDB ID: 6859
FusionGDB2.0 ID: 6859
HgeneTgene
Gene symbol

ARRDC1

EHMT1

Gene ID

92714

79813

Gene namearrestin domain containing 1euchromatic histone lysine methyltransferase 1
Synonyms-EHMT1-IT1|EUHMTASE1|Eu-HMTase1|FP13812|GLP|GLP1|KLEFS1|KMT1D
Cytomap

9q34.3

9q34.3

Type of geneprotein-codingprotein-coding
Descriptionarrestin domain-containing protein 1alpha-arrestin 1histone-lysine N-methyltransferase EHMT1EHMT1 intronic transcript 1G9a-like protein 1H3-K9-HMTase 5euchromatic histone-lysine N-methyltransferase 1histone H3-K9 methyltransferase 5histone-lysine N-methyltransferase, H3 lysine-9 specific 5lysine N-m
Modification date2020032020200313
UniProtAcc

Q9H2J1

Q9H9B1

Ensembl transtripts involved in fusion geneENST idsENST00000491911, ENST00000371421, 
ENST00000462484, ENST00000371394, 
ENST00000334856, ENST00000460843, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score4 X 4 X 5=8015 X 14 X 10=2100
# samples 821
** MAII scorelog2(8/80*10)=0log2(21/2100*10)=-3.32192809488736
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: ARRDC1 [Title/Abstract] AND EHMT1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)EHMT1(140513501)-ARRDC1(140507348), # samples:4
ARRDC1(140509452)-EHMT1(140611078), # samples:3
ARRDC1(140500287)-EHMT1(140605419), # samples:3
Anticipated loss of major functional domain due to fusion event.ARRDC1-EHMT1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ARRDC1-EHMT1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ARRDC1-EHMT1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
ARRDC1-EHMT1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
ARRDC1-EHMT1 seems lost the major protein functional domain in Tgene partner, which is a epigenetic factor due to the frame-shifted ORF.
ARRDC1-EHMT1 seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
EHMT1-ARRDC1 seems lost the major protein functional domain in Hgene partner, which is a epigenetic factor due to the frame-shifted ORF.
EHMT1-ARRDC1 seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneEHMT1

GO:0006325

chromatin organization

12004135

TgeneEHMT1

GO:0016571

histone methylation

12004135

TgeneEHMT1

GO:0018027

peptidyl-lysine dimethylation

20118233


check buttonFusion gene breakpoints across ARRDC1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across EHMT1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BLCATCGA-FD-A3SR-01AARRDC1chr9

140509452

+EHMT1chr9

140611078

+
ChimerDB4BLCATCGA-FD-A6TH-01AARRDC1chr9

140509452

+EHMT1chr9

140611078

+
ChimerDB4BRCATCGA-A8-A07I-01AARRDC1chr9

140500287

+EHMT1chr9

140605419

+
ChimerDB4BRCATCGA-A8-A07IARRDC1chr9

140500287

+EHMT1chr9

140605418

+
ChimerDB4COADTCGA-CA-5254-01AARRDC1chr9

140509452

+EHMT1chr9

140611078

+
ChimerDB4ESCATCGA-L5-A8NEARRDC1chr9

140509452

+EHMT1chr9

140611077

+
ChimerDB4OVTCGA-13-0916-01AARRDC1chr9

140500287

+EHMT1chr9

140605419

+
ChimerDB4STADTCGA-D7-6820-01AARRDC1chr9

140500287

+EHMT1chr9

140605419

+
ChimerDB4STADTCGA-VQ-A8E0ARRDC1chr9

140509452

+EHMT1chr9

140605418

+


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000371421ARRDC1chr9140509452+ENST00000462484EHMT1chr9140611077+388613016436421192
ENST00000371421ARRDC1chr9140509452+ENST00000462484EHMT1chr9140611078+388613016436421192

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000371421ENST00000462484ARRDC1chr9140509452+EHMT1chr9140611077+0.0034992840.99650073
ENST00000371421ENST00000462484ARRDC1chr9140509452+EHMT1chr9140611078+0.0034992840.99650073

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>6859_6859_1_ARRDC1-EHMT1_ARRDC1_chr9_140509452_ENST00000371421_EHMT1_chr9_140611077_ENST00000462484_length(amino acids)=1192AA_BP=0
MGRVQLFEISLSHGRVVYSPGEPLAGTVRVRLGAPLPFRAIRVTCIGSCGVSNKANDTAWVVEEGYFNSSLSLADKGSLPAGEHSFPFQF
LLPATAPTSFEGPFGKIVHQVRAAIHTPRFSKDHKCSLVFYILSPLNLNSIPDIEQPNVASATKKFSYKLVKTGSVVLTASTDLRGYVVG
QALQLHADVENQSGKDTSPVVASLLQKVSYKAKRWIHDVRTIAEVEGAGVKAWRRAQWHEQILVPALPQSALPGCSLIHIDYYLQVSLKA
PEATVTLPVFIGNIAVNHAPVSPRPGLGLPPGAPPLVVPSAPPQEEAEAEAAAGGPHFLDPVFLSTKSHSQRQPLLATLSSVPGAPEPCP
QDGSPASHPLHPPLCISTGATVPYFAEGSGGPVPTTSTLILPPEYSSWGYPYETPMAADEGSAEKQAGEAHMAADGETNGSCENSDASSH
ANAAKHTQDSARVNPQDGTNTLTRIAENGVSERDSEAAKQNHVTADDFVQTSVIGSNGYILNKPALQAQPLRTTSTLASSLPGHAAKTLP
GGAGKGRTPSAFPQTPAAPPATLGEGSADTEDRKLPAPGADVKVHRARKTMPKSVVGLHAASKDPREVREARDHKEPKEEINKNISDFGR
QQLLPPFPSLHQSLPQNQCYMATTKSQTACLPFVLAAAVSRKKKRRMGTYSLVPKKKTKVLKQRTVIEMFKSITHSTVGSKGEKDLGASS
LHVNGESLEMDSDEDDSEELEEDDGHGAEQAAAFPTEDSRTSKESMSEADRAQKMDGESEEEQESVDTGEEEEGGDESDLSSESSIKKKF
LKRKGKTDSPWIKPARKRRRRSRKKPSGALGSESYKSSAGSAEQTAPGDSTGYMEVSLDSLDLRVKGILSSQAEGLANGPDVLETDGLQE
VPLCSCRMETPKSREITTLANNQCMATESVDHELGRCTNSVVKYELMRPSNKAPLLVLCEDHRGRMVKHQCCPGCGYFCTAGNFMECQPE
SSISHRFHKDCASRVNNASYCPHCGEESSKAKEVTIAKADTTSTVTPVPGQEKGSALEGRADTTTGSAAGPPLSEDDKLQGAASHVPEGF
DPTGPAGLGRPTPGLSQGPGKETLESALIALDSEKPKKLRFHPKQLYFSARQGELQKVLLMLVDGIDPNFKMEHQNKRSPLHAAAEAGHV

--------------------------------------------------------------

>6859_6859_2_ARRDC1-EHMT1_ARRDC1_chr9_140509452_ENST00000371421_EHMT1_chr9_140611078_ENST00000462484_length(amino acids)=1192AA_BP=0
MGRVQLFEISLSHGRVVYSPGEPLAGTVRVRLGAPLPFRAIRVTCIGSCGVSNKANDTAWVVEEGYFNSSLSLADKGSLPAGEHSFPFQF
LLPATAPTSFEGPFGKIVHQVRAAIHTPRFSKDHKCSLVFYILSPLNLNSIPDIEQPNVASATKKFSYKLVKTGSVVLTASTDLRGYVVG
QALQLHADVENQSGKDTSPVVASLLQKVSYKAKRWIHDVRTIAEVEGAGVKAWRRAQWHEQILVPALPQSALPGCSLIHIDYYLQVSLKA
PEATVTLPVFIGNIAVNHAPVSPRPGLGLPPGAPPLVVPSAPPQEEAEAEAAAGGPHFLDPVFLSTKSHSQRQPLLATLSSVPGAPEPCP
QDGSPASHPLHPPLCISTGATVPYFAEGSGGPVPTTSTLILPPEYSSWGYPYETPMAADEGSAEKQAGEAHMAADGETNGSCENSDASSH
ANAAKHTQDSARVNPQDGTNTLTRIAENGVSERDSEAAKQNHVTADDFVQTSVIGSNGYILNKPALQAQPLRTTSTLASSLPGHAAKTLP
GGAGKGRTPSAFPQTPAAPPATLGEGSADTEDRKLPAPGADVKVHRARKTMPKSVVGLHAASKDPREVREARDHKEPKEEINKNISDFGR
QQLLPPFPSLHQSLPQNQCYMATTKSQTACLPFVLAAAVSRKKKRRMGTYSLVPKKKTKVLKQRTVIEMFKSITHSTVGSKGEKDLGASS
LHVNGESLEMDSDEDDSEELEEDDGHGAEQAAAFPTEDSRTSKESMSEADRAQKMDGESEEEQESVDTGEEEEGGDESDLSSESSIKKKF
LKRKGKTDSPWIKPARKRRRRSRKKPSGALGSESYKSSAGSAEQTAPGDSTGYMEVSLDSLDLRVKGILSSQAEGLANGPDVLETDGLQE
VPLCSCRMETPKSREITTLANNQCMATESVDHELGRCTNSVVKYELMRPSNKAPLLVLCEDHRGRMVKHQCCPGCGYFCTAGNFMECQPE
SSISHRFHKDCASRVNNASYCPHCGEESSKAKEVTIAKADTTSTVTPVPGQEKGSALEGRADTTTGSAAGPPLSEDDKLQGAASHVPEGF
DPTGPAGLGRPTPGLSQGPGKETLESALIALDSEKPKKLRFHPKQLYFSARQGELQKVLLMLVDGIDPNFKMEHQNKRSPLHAAAEAGHV

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr9:140513501/chr9:140507348)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ARRDC1

Q9H2J1

EHMT1

Q9H9B1

FUNCTION: Histone methyltransferase that specifically mono- and dimethylates 'Lys-9' of histone H3 (H3K9me1 and H3K9me2, respectively) in euchromatin. H3K9me represents a specific tag for epigenetic transcriptional repression by recruiting HP1 proteins to methylated histones. Also weakly methylates 'Lys-27' of histone H3 (H3K27me). Also required for DNA methylation, the histone methyltransferase activity is not required for DNA methylation, suggesting that these 2 activities function independently. Probably targeted to histone H3 by different DNA-binding proteins like E2F6, MGA, MAX and/or DP1. During G0 phase, it probably contributes to silencing of MYC- and E2F-responsive genes, suggesting a role in G0/G1 transition in cell cycle. In addition to the histone methyltransferase activity, also methylates non-histone proteins: mediates dimethylation of 'Lys-373' of p53/TP53. Represses the expression of mitochondrial function-related genes, perhaps by occupying their promoter regions, working in concert with probable chromatin reader BAZ2B (By similarity). {ECO:0000250|UniProtKB:Q5DW34, ECO:0000269|PubMed:12004135, ECO:0000269|PubMed:20118233}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneARRDC1chr9:140509452chr9:140611077ENST00000371421+78402_405412.3333333333333434.0MotifPPxY motif 1
HgeneARRDC1chr9:140509452chr9:140611078ENST00000371421+78402_405412.3333333333333434.0MotifPPxY motif 1
TgeneEHMT1chr9:140509452chr9:140611077ENST000003348561171292_12950826.0Compositional biasNote=Poly-Ala
TgeneEHMT1chr9:140509452chr9:140611077ENST00000334856117406_4090826.0Compositional biasNote=Poly-Glu
TgeneEHMT1chr9:140509452chr9:140611077ENST00000334856117442_4490826.0Compositional biasNote=Poly-Arg
TgeneEHMT1chr9:140509452chr9:140611077ENST000004608431271292_129528.3333333333333321299.0Compositional biasNote=Poly-Ala
TgeneEHMT1chr9:140509452chr9:140611077ENST00000460843127406_40928.3333333333333321299.0Compositional biasNote=Poly-Glu
TgeneEHMT1chr9:140509452chr9:140611077ENST00000460843127442_44928.3333333333333321299.0Compositional biasNote=Poly-Arg
TgeneEHMT1chr9:140509452chr9:140611077ENST000004624841161292_129528.333333333333332809.0Compositional biasNote=Poly-Ala
TgeneEHMT1chr9:140509452chr9:140611077ENST00000462484116406_40928.333333333333332809.0Compositional biasNote=Poly-Glu
TgeneEHMT1chr9:140509452chr9:140611077ENST00000462484116442_44928.333333333333332809.0Compositional biasNote=Poly-Arg
TgeneEHMT1chr9:140509452chr9:140611078ENST000003348561171292_12950826.0Compositional biasNote=Poly-Ala
TgeneEHMT1chr9:140509452chr9:140611078ENST00000334856117406_4090826.0Compositional biasNote=Poly-Glu
TgeneEHMT1chr9:140509452chr9:140611078ENST00000334856117442_4490826.0Compositional biasNote=Poly-Arg
TgeneEHMT1chr9:140509452chr9:140611078ENST000004608431271292_129528.3333333333333321299.0Compositional biasNote=Poly-Ala
TgeneEHMT1chr9:140509452chr9:140611078ENST00000460843127406_40928.3333333333333321299.0Compositional biasNote=Poly-Glu
TgeneEHMT1chr9:140509452chr9:140611078ENST00000460843127442_44928.3333333333333321299.0Compositional biasNote=Poly-Arg
TgeneEHMT1chr9:140509452chr9:140611078ENST000004624841161292_129528.333333333333332809.0Compositional biasNote=Poly-Ala
TgeneEHMT1chr9:140509452chr9:140611078ENST00000462484116406_40928.333333333333332809.0Compositional biasNote=Poly-Glu
TgeneEHMT1chr9:140509452chr9:140611078ENST00000462484116442_44928.333333333333332809.0Compositional biasNote=Poly-Arg
TgeneEHMT1chr9:140509452chr9:140611077ENST000003348561171060_11230826.0DomainPre-SET
TgeneEHMT1chr9:140509452chr9:140611077ENST000003348561171126_12430826.0DomainSET
TgeneEHMT1chr9:140509452chr9:140611077ENST000004608431271060_112328.3333333333333321299.0DomainPre-SET
TgeneEHMT1chr9:140509452chr9:140611077ENST000004608431271126_124328.3333333333333321299.0DomainSET
TgeneEHMT1chr9:140509452chr9:140611077ENST000004624841161060_112328.333333333333332809.0DomainPre-SET
TgeneEHMT1chr9:140509452chr9:140611077ENST000004624841161126_124328.333333333333332809.0DomainSET
TgeneEHMT1chr9:140509452chr9:140611078ENST000003348561171060_11230826.0DomainPre-SET
TgeneEHMT1chr9:140509452chr9:140611078ENST000003348561171126_12430826.0DomainSET
TgeneEHMT1chr9:140509452chr9:140611078ENST000004608431271060_112328.3333333333333321299.0DomainPre-SET
TgeneEHMT1chr9:140509452chr9:140611078ENST000004608431271126_124328.3333333333333321299.0DomainSET
TgeneEHMT1chr9:140509452chr9:140611078ENST000004624841161060_112328.333333333333332809.0DomainPre-SET
TgeneEHMT1chr9:140509452chr9:140611078ENST000004624841161126_124328.333333333333332809.0DomainSET
TgeneEHMT1chr9:140509452chr9:140611077ENST000003348561171136_11380826.0RegionNote=S-adenosyl-L-methionine binding
TgeneEHMT1chr9:140509452chr9:140611077ENST000003348561171200_12010826.0RegionNote=S-adenosyl-L-methionine binding
TgeneEHMT1chr9:140509452chr9:140611077ENST00000334856117905_9070826.0RegionNote=Histone H3K9me binding
TgeneEHMT1chr9:140509452chr9:140611077ENST000004608431271136_113828.3333333333333321299.0RegionNote=S-adenosyl-L-methionine binding
TgeneEHMT1chr9:140509452chr9:140611077ENST000004608431271200_120128.3333333333333321299.0RegionNote=S-adenosyl-L-methionine binding
TgeneEHMT1chr9:140509452chr9:140611077ENST00000460843127905_90728.3333333333333321299.0RegionNote=Histone H3K9me binding
TgeneEHMT1chr9:140509452chr9:140611077ENST000004624841161136_113828.333333333333332809.0RegionNote=S-adenosyl-L-methionine binding
TgeneEHMT1chr9:140509452chr9:140611077ENST000004624841161200_120128.333333333333332809.0RegionNote=S-adenosyl-L-methionine binding
TgeneEHMT1chr9:140509452chr9:140611077ENST00000462484116905_90728.333333333333332809.0RegionNote=Histone H3K9me binding
TgeneEHMT1chr9:140509452chr9:140611078ENST000003348561171136_11380826.0RegionNote=S-adenosyl-L-methionine binding
TgeneEHMT1chr9:140509452chr9:140611078ENST000003348561171200_12010826.0RegionNote=S-adenosyl-L-methionine binding
TgeneEHMT1chr9:140509452chr9:140611078ENST00000334856117905_9070826.0RegionNote=Histone H3K9me binding
TgeneEHMT1chr9:140509452chr9:140611078ENST000004608431271136_113828.3333333333333321299.0RegionNote=S-adenosyl-L-methionine binding
TgeneEHMT1chr9:140509452chr9:140611078ENST000004608431271200_120128.3333333333333321299.0RegionNote=S-adenosyl-L-methionine binding
TgeneEHMT1chr9:140509452chr9:140611078ENST00000460843127905_90728.3333333333333321299.0RegionNote=Histone H3K9me binding
TgeneEHMT1chr9:140509452chr9:140611078ENST000004624841161136_113828.333333333333332809.0RegionNote=S-adenosyl-L-methionine binding
TgeneEHMT1chr9:140509452chr9:140611078ENST000004624841161200_120128.333333333333332809.0RegionNote=S-adenosyl-L-methionine binding
TgeneEHMT1chr9:140509452chr9:140611078ENST00000462484116905_90728.333333333333332809.0RegionNote=Histone H3K9me binding
TgeneEHMT1chr9:140509452chr9:140611077ENST00000334856117737_7660826.0RepeatNote=ANK 1
TgeneEHMT1chr9:140509452chr9:140611077ENST00000334856117772_8010826.0RepeatNote=ANK 2
TgeneEHMT1chr9:140509452chr9:140611077ENST00000334856117805_8340826.0RepeatNote=ANK 3
TgeneEHMT1chr9:140509452chr9:140611077ENST00000334856117838_8680826.0RepeatNote=ANK 4
TgeneEHMT1chr9:140509452chr9:140611077ENST00000334856117872_9010826.0RepeatNote=ANK 5
TgeneEHMT1chr9:140509452chr9:140611077ENST00000334856117905_9340826.0RepeatNote=ANK 6
TgeneEHMT1chr9:140509452chr9:140611077ENST00000334856117938_9670826.0RepeatNote=ANK 7
TgeneEHMT1chr9:140509452chr9:140611077ENST00000334856117971_10040826.0RepeatNote=ANK 8
TgeneEHMT1chr9:140509452chr9:140611077ENST00000460843127737_76628.3333333333333321299.0RepeatNote=ANK 1
TgeneEHMT1chr9:140509452chr9:140611077ENST00000460843127772_80128.3333333333333321299.0RepeatNote=ANK 2
TgeneEHMT1chr9:140509452chr9:140611077ENST00000460843127805_83428.3333333333333321299.0RepeatNote=ANK 3
TgeneEHMT1chr9:140509452chr9:140611077ENST00000460843127838_86828.3333333333333321299.0RepeatNote=ANK 4
TgeneEHMT1chr9:140509452chr9:140611077ENST00000460843127872_90128.3333333333333321299.0RepeatNote=ANK 5
TgeneEHMT1chr9:140509452chr9:140611077ENST00000460843127905_93428.3333333333333321299.0RepeatNote=ANK 6
TgeneEHMT1chr9:140509452chr9:140611077ENST00000460843127938_96728.3333333333333321299.0RepeatNote=ANK 7
TgeneEHMT1chr9:140509452chr9:140611077ENST00000460843127971_100428.3333333333333321299.0RepeatNote=ANK 8
TgeneEHMT1chr9:140509452chr9:140611077ENST00000462484116737_76628.333333333333332809.0RepeatNote=ANK 1
TgeneEHMT1chr9:140509452chr9:140611077ENST00000462484116772_80128.333333333333332809.0RepeatNote=ANK 2
TgeneEHMT1chr9:140509452chr9:140611077ENST00000462484116805_83428.333333333333332809.0RepeatNote=ANK 3
TgeneEHMT1chr9:140509452chr9:140611077ENST00000462484116838_86828.333333333333332809.0RepeatNote=ANK 4
TgeneEHMT1chr9:140509452chr9:140611077ENST00000462484116872_90128.333333333333332809.0RepeatNote=ANK 5
TgeneEHMT1chr9:140509452chr9:140611077ENST00000462484116905_93428.333333333333332809.0RepeatNote=ANK 6
TgeneEHMT1chr9:140509452chr9:140611077ENST00000462484116938_96728.333333333333332809.0RepeatNote=ANK 7
TgeneEHMT1chr9:140509452chr9:140611077ENST00000462484116971_100428.333333333333332809.0RepeatNote=ANK 8
TgeneEHMT1chr9:140509452chr9:140611078ENST00000334856117737_7660826.0RepeatNote=ANK 1
TgeneEHMT1chr9:140509452chr9:140611078ENST00000334856117772_8010826.0RepeatNote=ANK 2
TgeneEHMT1chr9:140509452chr9:140611078ENST00000334856117805_8340826.0RepeatNote=ANK 3
TgeneEHMT1chr9:140509452chr9:140611078ENST00000334856117838_8680826.0RepeatNote=ANK 4
TgeneEHMT1chr9:140509452chr9:140611078ENST00000334856117872_9010826.0RepeatNote=ANK 5
TgeneEHMT1chr9:140509452chr9:140611078ENST00000334856117905_9340826.0RepeatNote=ANK 6
TgeneEHMT1chr9:140509452chr9:140611078ENST00000334856117938_9670826.0RepeatNote=ANK 7
TgeneEHMT1chr9:140509452chr9:140611078ENST00000334856117971_10040826.0RepeatNote=ANK 8
TgeneEHMT1chr9:140509452chr9:140611078ENST00000460843127737_76628.3333333333333321299.0RepeatNote=ANK 1
TgeneEHMT1chr9:140509452chr9:140611078ENST00000460843127772_80128.3333333333333321299.0RepeatNote=ANK 2
TgeneEHMT1chr9:140509452chr9:140611078ENST00000460843127805_83428.3333333333333321299.0RepeatNote=ANK 3
TgeneEHMT1chr9:140509452chr9:140611078ENST00000460843127838_86828.3333333333333321299.0RepeatNote=ANK 4
TgeneEHMT1chr9:140509452chr9:140611078ENST00000460843127872_90128.3333333333333321299.0RepeatNote=ANK 5
TgeneEHMT1chr9:140509452chr9:140611078ENST00000460843127905_93428.3333333333333321299.0RepeatNote=ANK 6
TgeneEHMT1chr9:140509452chr9:140611078ENST00000460843127938_96728.3333333333333321299.0RepeatNote=ANK 7
TgeneEHMT1chr9:140509452chr9:140611078ENST00000460843127971_100428.3333333333333321299.0RepeatNote=ANK 8
TgeneEHMT1chr9:140509452chr9:140611078ENST00000462484116737_76628.333333333333332809.0RepeatNote=ANK 1
TgeneEHMT1chr9:140509452chr9:140611078ENST00000462484116772_80128.333333333333332809.0RepeatNote=ANK 2
TgeneEHMT1chr9:140509452chr9:140611078ENST00000462484116805_83428.333333333333332809.0RepeatNote=ANK 3
TgeneEHMT1chr9:140509452chr9:140611078ENST00000462484116838_86828.333333333333332809.0RepeatNote=ANK 4
TgeneEHMT1chr9:140509452chr9:140611078ENST00000462484116872_90128.333333333333332809.0RepeatNote=ANK 5
TgeneEHMT1chr9:140509452chr9:140611078ENST00000462484116905_93428.333333333333332809.0RepeatNote=ANK 6
TgeneEHMT1chr9:140509452chr9:140611078ENST00000462484116938_96728.333333333333332809.0RepeatNote=ANK 7
TgeneEHMT1chr9:140509452chr9:140611078ENST00000462484116971_100428.333333333333332809.0RepeatNote=ANK 8

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneARRDC1chr9:140509452chr9:140611077ENST00000371421+78290_416412.3333333333333434.0Compositional biasNote=Pro-rich
HgeneARRDC1chr9:140509452chr9:140611078ENST00000371421+78290_416412.3333333333333434.0Compositional biasNote=Pro-rich
HgeneARRDC1chr9:140509452chr9:140611077ENST00000371421+78415_418412.3333333333333434.0MotifPPxY motif 2
HgeneARRDC1chr9:140509452chr9:140611078ENST00000371421+78415_418412.3333333333333434.0MotifPPxY motif 2


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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
ARRDC1
EHMT1


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to ARRDC1-EHMT1


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to ARRDC1-EHMT1


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource