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Center for Computational Systems Medicine level1
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:PRKAG2-KMT2C

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: PRKAG2-KMT2C
FusionPDB ID: 68637
FusionGDB2.0 ID: 68641
HgeneTgene
Gene symbol

PRKAG2

KMT2C

Gene ID

51422

58508

Gene nameprotein kinase AMP-activated non-catalytic subunit gamma 2lysine methyltransferase 2C
SynonymsAAKG|AAKG2|CMH6|H91620p|WPWSHALR|KLEFS2|MLL3
Cytomap

7q36.1

7q36.1

Type of geneprotein-codingprotein-coding
Description5'-AMP-activated protein kinase subunit gamma-2AMPK subunit gamma-2epididymis secretory sperm binding proteinprotein kinase, AMP-activated, gamma 2 non-catalytic subunithistone-lysine N-methyltransferase 2CALR-like proteinhistone-lysine N-methyltransferase MLL3histone-lysine N-methyltransferase, H3 lysine-4 specifichomologous to ALR proteinlysine (K)-specific methyltransferase 2Cmyeloid/lymphoid or mixed-lineage le
Modification date2020032020200320
UniProtAcc.

Q8NEZ4

Ensembl transtripts involved in fusion geneENST idsENST00000287878, ENST00000392801, 
ENST00000418337, ENST00000433631, 
ENST00000492843, ENST00000461529, 
ENST00000485241, ENST00000485655, 
ENST00000262189, ENST00000355193, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score16 X 11 X 10=176012 X 17 X 8=1632
# samples 2117
** MAII scorelog2(21/1760*10)=-3.06711419585854
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(17/1632*10)=-3.26303440583379
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: PRKAG2 [Title/Abstract] AND KMT2C [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)KMT2C(151917608)-PRKAG2(151372723), # samples:1
PRKAG2(151329155)-KMT2C(151834009), # samples:1
PRKAG2(151372506)-KMT2C(151860911), # samples:1
Anticipated loss of major functional domain due to fusion event.PRKAG2-KMT2C seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
PRKAG2-KMT2C seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
PRKAG2-KMT2C seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
PRKAG2-KMT2C seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
KMT2C-PRKAG2 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
KMT2C-PRKAG2 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
PRKAG2-KMT2C seems lost the major protein functional domain in Hgene partner, which is a cell metabolism gene due to the frame-shifted ORF.
PRKAG2-KMT2C seems lost the major protein functional domain in Hgene partner, which is a epigenetic factor due to the frame-shifted ORF.
PRKAG2-KMT2C seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
PRKAG2-KMT2C seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
PRKAG2-KMT2C seems lost the major protein functional domain in Tgene partner, which is a CGC due to the frame-shifted ORF.
PRKAG2-KMT2C seems lost the major protein functional domain in Tgene partner, which is a epigenetic factor due to the frame-shifted ORF.
PRKAG2-KMT2C seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
PRKAG2-KMT2C seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
PRKAG2-KMT2C seems lost the major protein functional domain in Tgene partner, which is a tumor suppressor due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgenePRKAG2

GO:0006469

negative regulation of protein kinase activity

17255938

TgeneKMT2C

GO:0097692

histone H3-K4 monomethylation

26324722


check buttonFusion gene breakpoints across PRKAG2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across KMT2C (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-AO-A12E-01APRKAG2chr7

151329155

-KMT2Cchr7

151834009

-
ChimerDB4PRADTCGA-EJ-A46G-01APRKAG2chr7

151372506

-KMT2Cchr7

151860911

-


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000287878PRKAG2chr7151329155-ENST00000262189KMT2Cchr7151834009-325912594931269258
ENST00000287878PRKAG2chr7151329155-ENST00000355193KMT2Cchr7151834009-325512594931269258
ENST00000433631PRKAG2chr7151329155-ENST00000262189KMT2Cchr7151834009-2652652240662140
ENST00000433631PRKAG2chr7151329155-ENST00000355193KMT2Cchr7151834009-2648652240662140
ENST00000492843PRKAG2chr7151329155-ENST00000262189KMT2Cchr7151834009-2703703291713140
ENST00000492843PRKAG2chr7151329155-ENST00000355193KMT2Cchr7151834009-2699703291713140
ENST00000287878PRKAG2chr7151372506-ENST00000262189KMT2Cchr7151860911-8082118949361741893
ENST00000287878PRKAG2chr7151372506-ENST00000355193KMT2Cchr7151860911-8249118949363451950
ENST00000433631PRKAG2chr7151372506-ENST00000262189KMT2Cchr7151860911-747558224055671775
ENST00000433631PRKAG2chr7151372506-ENST00000355193KMT2Cchr7151860911-764258224057381832
ENST00000492843PRKAG2chr7151372506-ENST00000262189KMT2Cchr7151860911-752663329156181775
ENST00000492843PRKAG2chr7151372506-ENST00000355193KMT2Cchr7151860911-769363329157891832

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000287878ENST00000262189PRKAG2chr7151329155-KMT2Cchr7151834009-0.0428118740.9571881
ENST00000287878ENST00000355193PRKAG2chr7151329155-KMT2Cchr7151834009-0.0387124120.9612876
ENST00000433631ENST00000262189PRKAG2chr7151329155-KMT2Cchr7151834009-0.43655460.5634454
ENST00000433631ENST00000355193PRKAG2chr7151329155-KMT2Cchr7151834009-0.431759480.5682405
ENST00000492843ENST00000262189PRKAG2chr7151329155-KMT2Cchr7151834009-0.433673320.5663267
ENST00000492843ENST00000355193PRKAG2chr7151329155-KMT2Cchr7151834009-0.43386130.5661387
ENST00000287878ENST00000262189PRKAG2chr7151372506-KMT2Cchr7151860911-0.0007001180.9992999
ENST00000287878ENST00000355193PRKAG2chr7151372506-KMT2Cchr7151860911-0.0007352580.9992648
ENST00000433631ENST00000262189PRKAG2chr7151372506-KMT2Cchr7151860911-0.0005622690.99943775
ENST00000433631ENST00000355193PRKAG2chr7151372506-KMT2Cchr7151860911-0.0005940350.999406
ENST00000492843ENST00000262189PRKAG2chr7151372506-KMT2Cchr7151860911-0.0006100460.9993899
ENST00000492843ENST00000355193PRKAG2chr7151372506-KMT2Cchr7151860911-0.0006428160.99935716

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>68637_68637_1_PRKAG2-KMT2C_PRKAG2_chr7_151329155_ENST00000287878_KMT2C_chr7_151834009_ENST00000262189_length(amino acids)=258AA_BP=
MVRVMGSAVMDTKKKKDVSSPGGSGGKKNASQKRRSLRVHIPDLSSFAMPLLDGDLEGSGKHSSRKVDSPFGPGSPSKGFFSRGPQPRPS
SPMSAPVRPKTSPGSPKTVFPFSYQESPPRSPRRMSFSGIFRSSSKESSPNSNPATSPGGIRFFSRSRKTSGLSSSPSTPTQVTKQHTFP

--------------------------------------------------------------

>68637_68637_2_PRKAG2-KMT2C_PRKAG2_chr7_151329155_ENST00000287878_KMT2C_chr7_151834009_ENST00000355193_length(amino acids)=258AA_BP=
MVRVMGSAVMDTKKKKDVSSPGGSGGKKNASQKRRSLRVHIPDLSSFAMPLLDGDLEGSGKHSSRKVDSPFGPGSPSKGFFSRGPQPRPS
SPMSAPVRPKTSPGSPKTVFPFSYQESPPRSPRRMSFSGIFRSSSKESSPNSNPATSPGGIRFFSRSRKTSGLSSSPSTPTQVTKQHTFP

--------------------------------------------------------------

>68637_68637_3_PRKAG2-KMT2C_PRKAG2_chr7_151329155_ENST00000433631_KMT2C_chr7_151834009_ENST00000262189_length(amino acids)=140AA_BP=
MSPLLWPQLPMKRFGSLRSNKKHKDQNRSTERRQSEPHGLFASGLSSSPSTPTQVTKQHTFPLESYKHEPERLENRIYASSSPPDTGQRF

--------------------------------------------------------------

>68637_68637_4_PRKAG2-KMT2C_PRKAG2_chr7_151329155_ENST00000433631_KMT2C_chr7_151834009_ENST00000355193_length(amino acids)=140AA_BP=
MSPLLWPQLPMKRFGSLRSNKKHKDQNRSTERRQSEPHGLFASGLSSSPSTPTQVTKQHTFPLESYKHEPERLENRIYASSSPPDTGQRF

--------------------------------------------------------------

>68637_68637_5_PRKAG2-KMT2C_PRKAG2_chr7_151329155_ENST00000492843_KMT2C_chr7_151834009_ENST00000262189_length(amino acids)=140AA_BP=
MSPLLWPQLPMKRFGSLRSNKKHKDQNRSTERRQSEPHGLFASGLSSSPSTPTQVTKQHTFPLESYKHEPERLENRIYASSSPPDTGQRF

--------------------------------------------------------------

>68637_68637_6_PRKAG2-KMT2C_PRKAG2_chr7_151329155_ENST00000492843_KMT2C_chr7_151834009_ENST00000355193_length(amino acids)=140AA_BP=
MSPLLWPQLPMKRFGSLRSNKKHKDQNRSTERRQSEPHGLFASGLSSSPSTPTQVTKQHTFPLESYKHEPERLENRIYASSSPPDTGQRF

--------------------------------------------------------------

>68637_68637_7_PRKAG2-KMT2C_PRKAG2_chr7_151372506_ENST00000287878_KMT2C_chr7_151860911_ENST00000262189_length(amino acids)=1893AA_BP=232
MVRVMGSAVMDTKKKKDVSSPGGSGGKKNASQKRRSLRVHIPDLSSFAMPLLDGDLEGSGKHSSRKVDSPFGPGSPSKGFFSRGPQPRPS
SPMSAPVRPKTSPGSPKTVFPFSYQESPPRSPRRMSFSGIFRSSSKESSPNSNPATSPGGIRFFSRSRKTSGLSSSPSTPTQVTKQHTFP
LESYKHEPERLENRIYASSSPPDTGQRFCPSSFQSPTRPPLASPTHYAPSKAIRKQQKEHAELIEDYRIKQQQQCAMAPPTMMPSVQPQP
PLIPGATPPTMSQPTFPMVPQQLQHQQHTTVISGHTSPVRMPSLPGWQPNSAPAHLPLNPPRIQPPIAQLPIKTCTPAPGTVSNANPQSG
PPPRVEFDDNNPFSESFQERERKERLREQQERQRIQLMQEVDRQRALQQRMEMEQHGMVGSEISSSRTSVSQIPFYSSDLPCDFMQPLGP
LQQSPQHQQQMGQVLQQQNIQQGSINSPSTQTFMQTNERRQVGPPSFVPDSPSIPVGSPNFSSVKQGHGNLSGTSFQQSPVRPSFTPALP
AAPPVANSSLPCGQDSTITHGHSYPGSTQSLIQLYSDIIPEEKGKKKRTRKKKRDDDAESTKAPSTPHSDITAPPTPGISETTSTPAVST
PSELPQQADQESVEPVGPSTPNMAAGQLCTELENKLPNSDFSQATPNQQTYANSEVDKLSMETPAKTEEIKLEKAETESCPGQEEPKLEE
QNGSKVEGNAVACPVSSAQSPPHSAGAPAAKGDSGNELLKHLLKNKKSSSLLNQKPEGSICSEDDCTKDNKLVEKQNPAEGLQTLGAQMQ
GGFGCGNQLPKTDGGSETKKQRSKRTQRTGEKAAPRSKKRKKDEEEKQAMYSSTDTFTHLKQQNNLSNPPTPPASLPPTPPPMACQKMAN
GFATTEELAGKAGVLVSHEVTKTLGPKPFQLPFRPQDDLLARALAQGPKTVDVPASLPTPPHNNQEELRIQDHCGDRDTPDSFVPSSSPE
SVVGVEVSRYPDLSLVKEEPPEPVPSPIIPILPSTAGKSSESRRNDIKTEPGTLYFASPFGPSPNGPRSGLISVAITLHPTAAENISSVV
AAFSDLLHVRIPNSYEVSSAPDVPSMGLVSSHRINPGLEYRQHLLLRGPPPGSANPPRLVSSYRLKQPNVPFPPTSNGLSGYKDSSHGIA
ESAALRPQWCCHCKVVILGSGVRKSFKDLTLLNKDSRESTKRVEKDIVFCSNNCFILYSSTAQAKNSENKESIPSLPQSPMRETPSKAFH
QYSNNISTLDVHCLPQLPEKASPPASPPIAFPPAFEAAQVEAKPDELKVTVKLKPRLRAVHGGFEDCRPLNKKWRGMKWKKWSIHIVIPK
GTFKPPCEDEIDEFLKKLGTSLKPDPVPKDYRKCCFCHEEGDGLTDGPARLLNLDLDLWVHLNCALWSTEVYETQAGALINVELALRRGL
QMKCVFCHKTGATSGCHRFRCTNIYHFTCAIKAQCMFFKDKTMLCPMHKPKGIHEQELSYFAVFRRVYVQRDEVRQIASIVQRGERDHTF
RVGSLIFHTIGQLLPQQMQAFHSPKALFPVGYEASRLYWSTRYANRRCRYLCSIEEKDGRPVFVIRIVEQGHEDLVLSDISPKGVWDKIL
EPVACVRKKSEMLQLFPAYLKGEDLFGLTVSAVARIAESLPGVEACENYTFRYGRNPLMELPLAVNPTGCARSEPKMSAHVKRFVLRPHT
LNSTSTSKSFQSTVTGELNAPYSKQFVHSKSSQYRKMKTEWKSNVYLARSRIQGLGLYAARDIEKHTMVIEYIGTIIRNEVANRKEKLYE
SQNRGVYMFRMDNDHVIDATLTGGPARYINHSCAPNCVAEVVTFERGHKIIISSSRRIQKGEELCYDYKFDFEDDQHKIPCHCGAVNCRK

--------------------------------------------------------------

>68637_68637_8_PRKAG2-KMT2C_PRKAG2_chr7_151372506_ENST00000287878_KMT2C_chr7_151860911_ENST00000355193_length(amino acids)=1950AA_BP=232
MVRVMGSAVMDTKKKKDVSSPGGSGGKKNASQKRRSLRVHIPDLSSFAMPLLDGDLEGSGKHSSRKVDSPFGPGSPSKGFFSRGPQPRPS
SPMSAPVRPKTSPGSPKTVFPFSYQESPPRSPRRMSFSGIFRSSSKESSPNSNPATSPGGIRFFSRSRKTSGLSSSPSTPTQVTKQHTFP
LESYKHEPERLENRIYASSSPPDTGQRFCPSSFQSPTRPPLASPTHYAPSKAIRKQQKEHAELIEDYRIKQQQQCAMAPPTMMPSVQPQP
PLIPGATPPTMSQPTFPMVPQQLQHQQHTTVISGHTSPVRMPSLPGWQPNSAPAHLPLNPPRIQPPIAQLPIKTCTPAPGTVSNANPQSG
PPPRVEFDDNNPFSESFQERERKERLREQQERQRIQLMQEVDRQRALQQRMEMEQHGMVGSEISSSRTSVSQIPFYSSDLPCDFMQPLGP
LQQSPQHQQQMGQVLQQQNIQQGSINSPSTQTFMQTNERRQVGPPSFVPDSPSIPVGSPNFSSVKQGHGNLSGTSFQQSPVRPSFTPALP
AAPPVANSSLPCGQDSTITHGHSYPGSTQSLIQLYSDIIPEEKGKKKRTRKKKRDDDAESTKAPSTPHSDITAPPTPGISETTSTPAVST
PSELPQQADQESVEPVGPSTPNMAAGQLCTELENKLPNSDFSQATPNQQTYANSEVDKLSMETPAKTEEIKLEKAETESCPGQEEPKLEE
QNGSKVEGNAVACPVSSAQSPPHSAGAPAAKGDSGNELLKHLLKNKKSSSLLNQKPEGSICSEDDCTKDNKLVEKQNPAEGLQTLGAQMQ
GGFGCGNQLPKTDGGSETKKQRSKRTQRTGEKAAPRSKKRKKDEEEKQAMYSSTDTFTHLKQVRQLSLLPLMEPIIGVNFAHFLPYGSGQ
FNSGNRLLGTFGSATLEGVSDYYSQLIYKQNNLSNPPTPPASLPPTPPPMACQKMANGFATTEELAGKAGVLVSHEVTKTLGPKPFQLPF
RPQDDLLARALAQGPKTVDVPASLPTPPHNNQEELRIQDHCGDRDTPDSFVPSSSPESVVGVEVSRYPDLSLVKEEPPEPVPSPIIPILP
STAGKSSESRRNDIKTEPGTLYFASPFGPSPNGPRSGLISVAITLHPTAAENISSVVAAFSDLLHVRIPNSYEVSSAPDVPSMGLVSSHR
INPGLEYRQHLLLRGPPPGSANPPRLVSSYRLKQPNVPFPPTSNGLSGYKDSSHGIAESAALRPQWCCHCKVVILGSGVRKSFKDLTLLN
KDSRESTKRVEKDIVFCSNNCFILYSSTAQAKNSENKESIPSLPQSPMRETPSKAFHQYSNNISTLDVHCLPQLPEKASPPASPPIAFPP
AFEAAQVEAKPDELKVTVKLKPRLRAVHGGFEDCRPLNKKWRGMKWKKWSIHIVIPKGTFKPPCEDEIDEFLKKLGTSLKPDPVPKDYRK
CCFCHEEGDGLTDGPARLLNLDLDLWVHLNCALWSTEVYETQAGALINVELALRRGLQMKCVFCHKTGATSGCHRFRCTNIYHFTCAIKA
QCMFFKDKTMLCPMHKPKGIHEQELSYFAVFRRVYVQRDEVRQIASIVQRGERDHTFRVGSLIFHTIGQLLPQQMQAFHSPKALFPVGYE
ASRLYWSTRYANRRCRYLCSIEEKDGRPVFVIRIVEQGHEDLVLSDISPKGVWDKILEPVACVRKKSEMLQLFPAYLKGEDLFGLTVSAV
ARIAESLPGVEACENYTFRYGRNPLMELPLAVNPTGCARSEPKMSAHVKRFVLRPHTLNSTSTSKSFQSTVTGELNAPYSKQFVHSKSSQ
YRKMKTEWKSNVYLARSRIQGLGLYAARDIEKHTMVIEYIGTIIRNEVANRKEKLYESQNRGVYMFRMDNDHVIDATLTGGPARYINHSC

--------------------------------------------------------------

>68637_68637_9_PRKAG2-KMT2C_PRKAG2_chr7_151372506_ENST00000433631_KMT2C_chr7_151860911_ENST00000262189_length(amino acids)=1775AA_BP=114
MSPLLWPQLPMKRFGSLRSNKKHKDQNRSTERRQSEPHGLFASGLSSSPSTPTQVTKQHTFPLESYKHEPERLENRIYASSSPPDTGQRF
CPSSFQSPTRPPLASPTHYAPSKAIRKQQKEHAELIEDYRIKQQQQCAMAPPTMMPSVQPQPPLIPGATPPTMSQPTFPMVPQQLQHQQH
TTVISGHTSPVRMPSLPGWQPNSAPAHLPLNPPRIQPPIAQLPIKTCTPAPGTVSNANPQSGPPPRVEFDDNNPFSESFQERERKERLRE
QQERQRIQLMQEVDRQRALQQRMEMEQHGMVGSEISSSRTSVSQIPFYSSDLPCDFMQPLGPLQQSPQHQQQMGQVLQQQNIQQGSINSP
STQTFMQTNERRQVGPPSFVPDSPSIPVGSPNFSSVKQGHGNLSGTSFQQSPVRPSFTPALPAAPPVANSSLPCGQDSTITHGHSYPGST
QSLIQLYSDIIPEEKGKKKRTRKKKRDDDAESTKAPSTPHSDITAPPTPGISETTSTPAVSTPSELPQQADQESVEPVGPSTPNMAAGQL
CTELENKLPNSDFSQATPNQQTYANSEVDKLSMETPAKTEEIKLEKAETESCPGQEEPKLEEQNGSKVEGNAVACPVSSAQSPPHSAGAP
AAKGDSGNELLKHLLKNKKSSSLLNQKPEGSICSEDDCTKDNKLVEKQNPAEGLQTLGAQMQGGFGCGNQLPKTDGGSETKKQRSKRTQR
TGEKAAPRSKKRKKDEEEKQAMYSSTDTFTHLKQQNNLSNPPTPPASLPPTPPPMACQKMANGFATTEELAGKAGVLVSHEVTKTLGPKP
FQLPFRPQDDLLARALAQGPKTVDVPASLPTPPHNNQEELRIQDHCGDRDTPDSFVPSSSPESVVGVEVSRYPDLSLVKEEPPEPVPSPI
IPILPSTAGKSSESRRNDIKTEPGTLYFASPFGPSPNGPRSGLISVAITLHPTAAENISSVVAAFSDLLHVRIPNSYEVSSAPDVPSMGL
VSSHRINPGLEYRQHLLLRGPPPGSANPPRLVSSYRLKQPNVPFPPTSNGLSGYKDSSHGIAESAALRPQWCCHCKVVILGSGVRKSFKD
LTLLNKDSRESTKRVEKDIVFCSNNCFILYSSTAQAKNSENKESIPSLPQSPMRETPSKAFHQYSNNISTLDVHCLPQLPEKASPPASPP
IAFPPAFEAAQVEAKPDELKVTVKLKPRLRAVHGGFEDCRPLNKKWRGMKWKKWSIHIVIPKGTFKPPCEDEIDEFLKKLGTSLKPDPVP
KDYRKCCFCHEEGDGLTDGPARLLNLDLDLWVHLNCALWSTEVYETQAGALINVELALRRGLQMKCVFCHKTGATSGCHRFRCTNIYHFT
CAIKAQCMFFKDKTMLCPMHKPKGIHEQELSYFAVFRRVYVQRDEVRQIASIVQRGERDHTFRVGSLIFHTIGQLLPQQMQAFHSPKALF
PVGYEASRLYWSTRYANRRCRYLCSIEEKDGRPVFVIRIVEQGHEDLVLSDISPKGVWDKILEPVACVRKKSEMLQLFPAYLKGEDLFGL
TVSAVARIAESLPGVEACENYTFRYGRNPLMELPLAVNPTGCARSEPKMSAHVKRFVLRPHTLNSTSTSKSFQSTVTGELNAPYSKQFVH
SKSSQYRKMKTEWKSNVYLARSRIQGLGLYAARDIEKHTMVIEYIGTIIRNEVANRKEKLYESQNRGVYMFRMDNDHVIDATLTGGPARY

--------------------------------------------------------------

>68637_68637_10_PRKAG2-KMT2C_PRKAG2_chr7_151372506_ENST00000433631_KMT2C_chr7_151860911_ENST00000355193_length(amino acids)=1832AA_BP=114
MSPLLWPQLPMKRFGSLRSNKKHKDQNRSTERRQSEPHGLFASGLSSSPSTPTQVTKQHTFPLESYKHEPERLENRIYASSSPPDTGQRF
CPSSFQSPTRPPLASPTHYAPSKAIRKQQKEHAELIEDYRIKQQQQCAMAPPTMMPSVQPQPPLIPGATPPTMSQPTFPMVPQQLQHQQH
TTVISGHTSPVRMPSLPGWQPNSAPAHLPLNPPRIQPPIAQLPIKTCTPAPGTVSNANPQSGPPPRVEFDDNNPFSESFQERERKERLRE
QQERQRIQLMQEVDRQRALQQRMEMEQHGMVGSEISSSRTSVSQIPFYSSDLPCDFMQPLGPLQQSPQHQQQMGQVLQQQNIQQGSINSP
STQTFMQTNERRQVGPPSFVPDSPSIPVGSPNFSSVKQGHGNLSGTSFQQSPVRPSFTPALPAAPPVANSSLPCGQDSTITHGHSYPGST
QSLIQLYSDIIPEEKGKKKRTRKKKRDDDAESTKAPSTPHSDITAPPTPGISETTSTPAVSTPSELPQQADQESVEPVGPSTPNMAAGQL
CTELENKLPNSDFSQATPNQQTYANSEVDKLSMETPAKTEEIKLEKAETESCPGQEEPKLEEQNGSKVEGNAVACPVSSAQSPPHSAGAP
AAKGDSGNELLKHLLKNKKSSSLLNQKPEGSICSEDDCTKDNKLVEKQNPAEGLQTLGAQMQGGFGCGNQLPKTDGGSETKKQRSKRTQR
TGEKAAPRSKKRKKDEEEKQAMYSSTDTFTHLKQVRQLSLLPLMEPIIGVNFAHFLPYGSGQFNSGNRLLGTFGSATLEGVSDYYSQLIY
KQNNLSNPPTPPASLPPTPPPMACQKMANGFATTEELAGKAGVLVSHEVTKTLGPKPFQLPFRPQDDLLARALAQGPKTVDVPASLPTPP
HNNQEELRIQDHCGDRDTPDSFVPSSSPESVVGVEVSRYPDLSLVKEEPPEPVPSPIIPILPSTAGKSSESRRNDIKTEPGTLYFASPFG
PSPNGPRSGLISVAITLHPTAAENISSVVAAFSDLLHVRIPNSYEVSSAPDVPSMGLVSSHRINPGLEYRQHLLLRGPPPGSANPPRLVS
SYRLKQPNVPFPPTSNGLSGYKDSSHGIAESAALRPQWCCHCKVVILGSGVRKSFKDLTLLNKDSRESTKRVEKDIVFCSNNCFILYSST
AQAKNSENKESIPSLPQSPMRETPSKAFHQYSNNISTLDVHCLPQLPEKASPPASPPIAFPPAFEAAQVEAKPDELKVTVKLKPRLRAVH
GGFEDCRPLNKKWRGMKWKKWSIHIVIPKGTFKPPCEDEIDEFLKKLGTSLKPDPVPKDYRKCCFCHEEGDGLTDGPARLLNLDLDLWVH
LNCALWSTEVYETQAGALINVELALRRGLQMKCVFCHKTGATSGCHRFRCTNIYHFTCAIKAQCMFFKDKTMLCPMHKPKGIHEQELSYF
AVFRRVYVQRDEVRQIASIVQRGERDHTFRVGSLIFHTIGQLLPQQMQAFHSPKALFPVGYEASRLYWSTRYANRRCRYLCSIEEKDGRP
VFVIRIVEQGHEDLVLSDISPKGVWDKILEPVACVRKKSEMLQLFPAYLKGEDLFGLTVSAVARIAESLPGVEACENYTFRYGRNPLMEL
PLAVNPTGCARSEPKMSAHVKRFVLRPHTLNSTSTSKSFQSTVTGELNAPYSKQFVHSKSSQYRKMKTEWKSNVYLARSRIQGLGLYAAR
DIEKHTMVIEYIGTIIRNEVANRKEKLYESQNRGVYMFRMDNDHVIDATLTGGPARYINHSCAPNCVAEVVTFERGHKIIISSSRRIQKG

--------------------------------------------------------------

>68637_68637_11_PRKAG2-KMT2C_PRKAG2_chr7_151372506_ENST00000492843_KMT2C_chr7_151860911_ENST00000262189_length(amino acids)=1775AA_BP=114
MSPLLWPQLPMKRFGSLRSNKKHKDQNRSTERRQSEPHGLFASGLSSSPSTPTQVTKQHTFPLESYKHEPERLENRIYASSSPPDTGQRF
CPSSFQSPTRPPLASPTHYAPSKAIRKQQKEHAELIEDYRIKQQQQCAMAPPTMMPSVQPQPPLIPGATPPTMSQPTFPMVPQQLQHQQH
TTVISGHTSPVRMPSLPGWQPNSAPAHLPLNPPRIQPPIAQLPIKTCTPAPGTVSNANPQSGPPPRVEFDDNNPFSESFQERERKERLRE
QQERQRIQLMQEVDRQRALQQRMEMEQHGMVGSEISSSRTSVSQIPFYSSDLPCDFMQPLGPLQQSPQHQQQMGQVLQQQNIQQGSINSP
STQTFMQTNERRQVGPPSFVPDSPSIPVGSPNFSSVKQGHGNLSGTSFQQSPVRPSFTPALPAAPPVANSSLPCGQDSTITHGHSYPGST
QSLIQLYSDIIPEEKGKKKRTRKKKRDDDAESTKAPSTPHSDITAPPTPGISETTSTPAVSTPSELPQQADQESVEPVGPSTPNMAAGQL
CTELENKLPNSDFSQATPNQQTYANSEVDKLSMETPAKTEEIKLEKAETESCPGQEEPKLEEQNGSKVEGNAVACPVSSAQSPPHSAGAP
AAKGDSGNELLKHLLKNKKSSSLLNQKPEGSICSEDDCTKDNKLVEKQNPAEGLQTLGAQMQGGFGCGNQLPKTDGGSETKKQRSKRTQR
TGEKAAPRSKKRKKDEEEKQAMYSSTDTFTHLKQQNNLSNPPTPPASLPPTPPPMACQKMANGFATTEELAGKAGVLVSHEVTKTLGPKP
FQLPFRPQDDLLARALAQGPKTVDVPASLPTPPHNNQEELRIQDHCGDRDTPDSFVPSSSPESVVGVEVSRYPDLSLVKEEPPEPVPSPI
IPILPSTAGKSSESRRNDIKTEPGTLYFASPFGPSPNGPRSGLISVAITLHPTAAENISSVVAAFSDLLHVRIPNSYEVSSAPDVPSMGL
VSSHRINPGLEYRQHLLLRGPPPGSANPPRLVSSYRLKQPNVPFPPTSNGLSGYKDSSHGIAESAALRPQWCCHCKVVILGSGVRKSFKD
LTLLNKDSRESTKRVEKDIVFCSNNCFILYSSTAQAKNSENKESIPSLPQSPMRETPSKAFHQYSNNISTLDVHCLPQLPEKASPPASPP
IAFPPAFEAAQVEAKPDELKVTVKLKPRLRAVHGGFEDCRPLNKKWRGMKWKKWSIHIVIPKGTFKPPCEDEIDEFLKKLGTSLKPDPVP
KDYRKCCFCHEEGDGLTDGPARLLNLDLDLWVHLNCALWSTEVYETQAGALINVELALRRGLQMKCVFCHKTGATSGCHRFRCTNIYHFT
CAIKAQCMFFKDKTMLCPMHKPKGIHEQELSYFAVFRRVYVQRDEVRQIASIVQRGERDHTFRVGSLIFHTIGQLLPQQMQAFHSPKALF
PVGYEASRLYWSTRYANRRCRYLCSIEEKDGRPVFVIRIVEQGHEDLVLSDISPKGVWDKILEPVACVRKKSEMLQLFPAYLKGEDLFGL
TVSAVARIAESLPGVEACENYTFRYGRNPLMELPLAVNPTGCARSEPKMSAHVKRFVLRPHTLNSTSTSKSFQSTVTGELNAPYSKQFVH
SKSSQYRKMKTEWKSNVYLARSRIQGLGLYAARDIEKHTMVIEYIGTIIRNEVANRKEKLYESQNRGVYMFRMDNDHVIDATLTGGPARY

--------------------------------------------------------------

>68637_68637_12_PRKAG2-KMT2C_PRKAG2_chr7_151372506_ENST00000492843_KMT2C_chr7_151860911_ENST00000355193_length(amino acids)=1832AA_BP=114
MSPLLWPQLPMKRFGSLRSNKKHKDQNRSTERRQSEPHGLFASGLSSSPSTPTQVTKQHTFPLESYKHEPERLENRIYASSSPPDTGQRF
CPSSFQSPTRPPLASPTHYAPSKAIRKQQKEHAELIEDYRIKQQQQCAMAPPTMMPSVQPQPPLIPGATPPTMSQPTFPMVPQQLQHQQH
TTVISGHTSPVRMPSLPGWQPNSAPAHLPLNPPRIQPPIAQLPIKTCTPAPGTVSNANPQSGPPPRVEFDDNNPFSESFQERERKERLRE
QQERQRIQLMQEVDRQRALQQRMEMEQHGMVGSEISSSRTSVSQIPFYSSDLPCDFMQPLGPLQQSPQHQQQMGQVLQQQNIQQGSINSP
STQTFMQTNERRQVGPPSFVPDSPSIPVGSPNFSSVKQGHGNLSGTSFQQSPVRPSFTPALPAAPPVANSSLPCGQDSTITHGHSYPGST
QSLIQLYSDIIPEEKGKKKRTRKKKRDDDAESTKAPSTPHSDITAPPTPGISETTSTPAVSTPSELPQQADQESVEPVGPSTPNMAAGQL
CTELENKLPNSDFSQATPNQQTYANSEVDKLSMETPAKTEEIKLEKAETESCPGQEEPKLEEQNGSKVEGNAVACPVSSAQSPPHSAGAP
AAKGDSGNELLKHLLKNKKSSSLLNQKPEGSICSEDDCTKDNKLVEKQNPAEGLQTLGAQMQGGFGCGNQLPKTDGGSETKKQRSKRTQR
TGEKAAPRSKKRKKDEEEKQAMYSSTDTFTHLKQVRQLSLLPLMEPIIGVNFAHFLPYGSGQFNSGNRLLGTFGSATLEGVSDYYSQLIY
KQNNLSNPPTPPASLPPTPPPMACQKMANGFATTEELAGKAGVLVSHEVTKTLGPKPFQLPFRPQDDLLARALAQGPKTVDVPASLPTPP
HNNQEELRIQDHCGDRDTPDSFVPSSSPESVVGVEVSRYPDLSLVKEEPPEPVPSPIIPILPSTAGKSSESRRNDIKTEPGTLYFASPFG
PSPNGPRSGLISVAITLHPTAAENISSVVAAFSDLLHVRIPNSYEVSSAPDVPSMGLVSSHRINPGLEYRQHLLLRGPPPGSANPPRLVS
SYRLKQPNVPFPPTSNGLSGYKDSSHGIAESAALRPQWCCHCKVVILGSGVRKSFKDLTLLNKDSRESTKRVEKDIVFCSNNCFILYSST
AQAKNSENKESIPSLPQSPMRETPSKAFHQYSNNISTLDVHCLPQLPEKASPPASPPIAFPPAFEAAQVEAKPDELKVTVKLKPRLRAVH
GGFEDCRPLNKKWRGMKWKKWSIHIVIPKGTFKPPCEDEIDEFLKKLGTSLKPDPVPKDYRKCCFCHEEGDGLTDGPARLLNLDLDLWVH
LNCALWSTEVYETQAGALINVELALRRGLQMKCVFCHKTGATSGCHRFRCTNIYHFTCAIKAQCMFFKDKTMLCPMHKPKGIHEQELSYF
AVFRRVYVQRDEVRQIASIVQRGERDHTFRVGSLIFHTIGQLLPQQMQAFHSPKALFPVGYEASRLYWSTRYANRRCRYLCSIEEKDGRP
VFVIRIVEQGHEDLVLSDISPKGVWDKILEPVACVRKKSEMLQLFPAYLKGEDLFGLTVSAVARIAESLPGVEACENYTFRYGRNPLMEL
PLAVNPTGCARSEPKMSAHVKRFVLRPHTLNSTSTSKSFQSTVTGELNAPYSKQFVHSKSSQYRKMKTEWKSNVYLARSRIQGLGLYAAR
DIEKHTMVIEYIGTIIRNEVANRKEKLYESQNRGVYMFRMDNDHVIDATLTGGPARYINHSCAPNCVAEVVTFERGHKIIISSSRRIQKG

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Top

Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr7:151917608/chr7:151372723)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.KMT2C

Q8NEZ4

FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Histone methyltransferase that methylates 'Lys-4' of histone H3 (PubMed:22266653). H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. Central component of the MLL2/3 complex, a coactivator complex of nuclear receptors, involved in transcriptional coactivation. KMT2C/MLL3 may be a catalytic subunit of this complex. May be involved in leukemogenesis and developmental disorder. {ECO:0000269|PubMed:17500065, ECO:0000269|PubMed:22266653}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneKMT2Cchr7:151372506chr7:151860911ENST0000026218941593391_34333250.04912.0Coiled coilOntology_term=ECO:0000255
TgeneKMT2Cchr7:151372506chr7:151860911ENST0000035519341603391_34333250.04969.0Coiled coilOntology_term=ECO:0000255
TgeneKMT2Cchr7:151372506chr7:151860911ENST0000026218941593277_33813250.04912.0Compositional biasNote=Pro-rich
TgeneKMT2Cchr7:151372506chr7:151860911ENST0000035519341603277_33813250.04969.0Compositional biasNote=Pro-rich
TgeneKMT2Cchr7:151329155chr7:151834009ENST0000026218957594895_49114881.04912.0DomainPost-SET
TgeneKMT2Cchr7:151372506chr7:151860911ENST0000026218941594545_46053250.04912.0DomainFYR N-terminal
TgeneKMT2Cchr7:151372506chr7:151860911ENST0000026218941594606_46913250.04912.0DomainFYR C-terminal
TgeneKMT2Cchr7:151372506chr7:151860911ENST0000026218941594771_48873250.04912.0DomainSET
TgeneKMT2Cchr7:151372506chr7:151860911ENST0000026218941594895_49113250.04912.0DomainPost-SET
TgeneKMT2Cchr7:151372506chr7:151860911ENST0000035519341604545_46053250.04969.0DomainFYR N-terminal
TgeneKMT2Cchr7:151372506chr7:151860911ENST0000035519341604606_46913250.04969.0DomainFYR C-terminal
TgeneKMT2Cchr7:151372506chr7:151860911ENST0000035519341604771_48873250.04969.0DomainSET
TgeneKMT2Cchr7:151372506chr7:151860911ENST0000035519341604895_49113250.04969.0DomainPost-SET
TgeneKMT2Cchr7:151372506chr7:151860911ENST0000026218941594848_48493250.04912.0RegionS-adenosyl-L-methionine binding
TgeneKMT2Cchr7:151372506chr7:151860911ENST0000035519341604848_48493250.04969.0RegionS-adenosyl-L-methionine binding
TgeneKMT2Cchr7:151372506chr7:151860911ENST0000026218941594399_44393250.04912.0Zinc fingerC2HC pre-PHD-type 2
TgeneKMT2Cchr7:151372506chr7:151860911ENST0000026218941594460_45073250.04912.0Zinc fingerPHD-type 8
TgeneKMT2Cchr7:151372506chr7:151860911ENST0000035519341604399_44393250.04969.0Zinc fingerC2HC pre-PHD-type 2
TgeneKMT2Cchr7:151372506chr7:151860911ENST0000035519341604460_45073250.04969.0Zinc fingerPHD-type 8

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePRKAG2chr7:151329155chr7:151834009ENST00000287878-516275_335251.33333333333334570.0DomainCBS 1
HgenePRKAG2chr7:151329155chr7:151834009ENST00000287878-516357_415251.33333333333334570.0DomainCBS 2
HgenePRKAG2chr7:151329155chr7:151834009ENST00000287878-516430_492251.33333333333334570.0DomainCBS 3
HgenePRKAG2chr7:151329155chr7:151834009ENST00000287878-516504_562251.33333333333334570.0DomainCBS 4
HgenePRKAG2chr7:151329155chr7:151834009ENST00000392801-516275_335207.33333333333334526.0DomainCBS 1
HgenePRKAG2chr7:151329155chr7:151834009ENST00000392801-516357_415207.33333333333334526.0DomainCBS 2
HgenePRKAG2chr7:151329155chr7:151834009ENST00000392801-516430_492207.33333333333334526.0DomainCBS 3
HgenePRKAG2chr7:151329155chr7:151834009ENST00000392801-516504_562207.33333333333334526.0DomainCBS 4
HgenePRKAG2chr7:151329155chr7:151834009ENST00000418337-112275_33510.333333333333334329.0DomainCBS 1
HgenePRKAG2chr7:151329155chr7:151834009ENST00000418337-112357_41510.333333333333334329.0DomainCBS 2
HgenePRKAG2chr7:151329155chr7:151834009ENST00000418337-112430_49210.333333333333334329.0DomainCBS 3
HgenePRKAG2chr7:151329155chr7:151834009ENST00000418337-112504_56210.333333333333334329.0DomainCBS 4
HgenePRKAG2chr7:151372506chr7:151860911ENST00000287878-416275_335228.0570.0DomainCBS 1
HgenePRKAG2chr7:151372506chr7:151860911ENST00000287878-416357_415228.0570.0DomainCBS 2
HgenePRKAG2chr7:151372506chr7:151860911ENST00000287878-416430_492228.0570.0DomainCBS 3
HgenePRKAG2chr7:151372506chr7:151860911ENST00000287878-416504_562228.0570.0DomainCBS 4
HgenePRKAG2chr7:151372506chr7:151860911ENST00000392801-416275_335184.0526.0DomainCBS 1
HgenePRKAG2chr7:151372506chr7:151860911ENST00000392801-416357_415184.0526.0DomainCBS 2
HgenePRKAG2chr7:151372506chr7:151860911ENST00000392801-416430_492184.0526.0DomainCBS 3
HgenePRKAG2chr7:151372506chr7:151860911ENST00000392801-416504_562184.0526.0DomainCBS 4
HgenePRKAG2chr7:151372506chr7:151860911ENST00000418337-112275_3350329.0DomainCBS 1
HgenePRKAG2chr7:151372506chr7:151860911ENST00000418337-112357_4150329.0DomainCBS 2
HgenePRKAG2chr7:151372506chr7:151860911ENST00000418337-112430_4920329.0DomainCBS 3
HgenePRKAG2chr7:151372506chr7:151860911ENST00000418337-112504_5620329.0DomainCBS 4
HgenePRKAG2chr7:151329155chr7:151834009ENST00000287878-516370_391251.33333333333334570.0MotifNote=AMPK pseudosubstrate
HgenePRKAG2chr7:151329155chr7:151834009ENST00000392801-516370_391207.33333333333334526.0MotifNote=AMPK pseudosubstrate
HgenePRKAG2chr7:151329155chr7:151834009ENST00000418337-112370_39110.333333333333334329.0MotifNote=AMPK pseudosubstrate
HgenePRKAG2chr7:151372506chr7:151860911ENST00000287878-416370_391228.0570.0MotifNote=AMPK pseudosubstrate
HgenePRKAG2chr7:151372506chr7:151860911ENST00000392801-416370_391184.0526.0MotifNote=AMPK pseudosubstrate
HgenePRKAG2chr7:151372506chr7:151860911ENST00000418337-112370_3910329.0MotifNote=AMPK pseudosubstrate
HgenePRKAG2chr7:151329155chr7:151834009ENST00000287878-516319_322251.33333333333334570.0Nucleotide bindingAMP%2C ADP or ATP 1
HgenePRKAG2chr7:151329155chr7:151834009ENST00000287878-516383_384251.33333333333334570.0Nucleotide bindingAMP%2C ADP or ATP 1
HgenePRKAG2chr7:151329155chr7:151834009ENST00000287878-516458_459251.33333333333334570.0Nucleotide bindingAMP 3
HgenePRKAG2chr7:151329155chr7:151834009ENST00000287878-516474_477251.33333333333334570.0Nucleotide bindingAMP%2C ADP or ATP 2
HgenePRKAG2chr7:151329155chr7:151834009ENST00000287878-516530_531251.33333333333334570.0Nucleotide bindingAMP%2C ADP or ATP 2
HgenePRKAG2chr7:151329155chr7:151834009ENST00000287878-516546_549251.33333333333334570.0Nucleotide bindingAMP 3
HgenePRKAG2chr7:151329155chr7:151834009ENST00000392801-516319_322207.33333333333334526.0Nucleotide bindingAMP%2C ADP or ATP 1
HgenePRKAG2chr7:151329155chr7:151834009ENST00000392801-516383_384207.33333333333334526.0Nucleotide bindingAMP%2C ADP or ATP 1
HgenePRKAG2chr7:151329155chr7:151834009ENST00000392801-516458_459207.33333333333334526.0Nucleotide bindingAMP 3
HgenePRKAG2chr7:151329155chr7:151834009ENST00000392801-516474_477207.33333333333334526.0Nucleotide bindingAMP%2C ADP or ATP 2
HgenePRKAG2chr7:151329155chr7:151834009ENST00000392801-516530_531207.33333333333334526.0Nucleotide bindingAMP%2C ADP or ATP 2
HgenePRKAG2chr7:151329155chr7:151834009ENST00000392801-516546_549207.33333333333334526.0Nucleotide bindingAMP 3
HgenePRKAG2chr7:151329155chr7:151834009ENST00000418337-112319_32210.333333333333334329.0Nucleotide bindingAMP%2C ADP or ATP 1
HgenePRKAG2chr7:151329155chr7:151834009ENST00000418337-112383_38410.333333333333334329.0Nucleotide bindingAMP%2C ADP or ATP 1
HgenePRKAG2chr7:151329155chr7:151834009ENST00000418337-112458_45910.333333333333334329.0Nucleotide bindingAMP 3
HgenePRKAG2chr7:151329155chr7:151834009ENST00000418337-112474_47710.333333333333334329.0Nucleotide bindingAMP%2C ADP or ATP 2
HgenePRKAG2chr7:151329155chr7:151834009ENST00000418337-112530_53110.333333333333334329.0Nucleotide bindingAMP%2C ADP or ATP 2
HgenePRKAG2chr7:151329155chr7:151834009ENST00000418337-112546_54910.333333333333334329.0Nucleotide bindingAMP 3
HgenePRKAG2chr7:151372506chr7:151860911ENST00000287878-416319_322228.0570.0Nucleotide bindingAMP%2C ADP or ATP 1
HgenePRKAG2chr7:151372506chr7:151860911ENST00000287878-416383_384228.0570.0Nucleotide bindingAMP%2C ADP or ATP 1
HgenePRKAG2chr7:151372506chr7:151860911ENST00000287878-416458_459228.0570.0Nucleotide bindingAMP 3
HgenePRKAG2chr7:151372506chr7:151860911ENST00000287878-416474_477228.0570.0Nucleotide bindingAMP%2C ADP or ATP 2
HgenePRKAG2chr7:151372506chr7:151860911ENST00000287878-416530_531228.0570.0Nucleotide bindingAMP%2C ADP or ATP 2
HgenePRKAG2chr7:151372506chr7:151860911ENST00000287878-416546_549228.0570.0Nucleotide bindingAMP 3
HgenePRKAG2chr7:151372506chr7:151860911ENST00000392801-416319_322184.0526.0Nucleotide bindingAMP%2C ADP or ATP 1
HgenePRKAG2chr7:151372506chr7:151860911ENST00000392801-416383_384184.0526.0Nucleotide bindingAMP%2C ADP or ATP 1
HgenePRKAG2chr7:151372506chr7:151860911ENST00000392801-416458_459184.0526.0Nucleotide bindingAMP 3
HgenePRKAG2chr7:151372506chr7:151860911ENST00000392801-416474_477184.0526.0Nucleotide bindingAMP%2C ADP or ATP 2
HgenePRKAG2chr7:151372506chr7:151860911ENST00000392801-416530_531184.0526.0Nucleotide bindingAMP%2C ADP or ATP 2
HgenePRKAG2chr7:151372506chr7:151860911ENST00000392801-416546_549184.0526.0Nucleotide bindingAMP 3
HgenePRKAG2chr7:151372506chr7:151860911ENST00000418337-112319_3220329.0Nucleotide bindingAMP%2C ADP or ATP 1
HgenePRKAG2chr7:151372506chr7:151860911ENST00000418337-112383_3840329.0Nucleotide bindingAMP%2C ADP or ATP 1
HgenePRKAG2chr7:151372506chr7:151860911ENST00000418337-112458_4590329.0Nucleotide bindingAMP 3
HgenePRKAG2chr7:151372506chr7:151860911ENST00000418337-112474_4770329.0Nucleotide bindingAMP%2C ADP or ATP 2
HgenePRKAG2chr7:151372506chr7:151860911ENST00000418337-112530_5310329.0Nucleotide bindingAMP%2C ADP or ATP 2
HgenePRKAG2chr7:151372506chr7:151860911ENST00000418337-112546_5490329.0Nucleotide bindingAMP 3
TgeneKMT2Cchr7:151329155chr7:151834009ENST0000026218957591338_13664881.04912.0Coiled coilOntology_term=ECO:0000255
TgeneKMT2Cchr7:151329155chr7:151834009ENST0000026218957591754_17874881.04912.0Coiled coilOntology_term=ECO:0000255
TgeneKMT2Cchr7:151329155chr7:151834009ENST0000026218957593054_30814881.04912.0Coiled coilOntology_term=ECO:0000255
TgeneKMT2Cchr7:151329155chr7:151834009ENST0000026218957593173_32724881.04912.0Coiled coilOntology_term=ECO:0000255
TgeneKMT2Cchr7:151329155chr7:151834009ENST0000026218957593391_34334881.04912.0Coiled coilOntology_term=ECO:0000255
TgeneKMT2Cchr7:151329155chr7:151834009ENST000002621895759644_6724881.04912.0Coiled coilOntology_term=ECO:0000255
TgeneKMT2Cchr7:151329155chr7:151834009ENST00000262189575992_1124881.04912.0Coiled coilOntology_term=ECO:0000255
TgeneKMT2Cchr7:151329155chr7:151834009ENST0000035519358601338_13664938.04969.0Coiled coilOntology_term=ECO:0000255
TgeneKMT2Cchr7:151329155chr7:151834009ENST0000035519358601754_17874938.04969.0Coiled coilOntology_term=ECO:0000255
TgeneKMT2Cchr7:151329155chr7:151834009ENST0000035519358603054_30814938.04969.0Coiled coilOntology_term=ECO:0000255
TgeneKMT2Cchr7:151329155chr7:151834009ENST0000035519358603173_32724938.04969.0Coiled coilOntology_term=ECO:0000255
TgeneKMT2Cchr7:151329155chr7:151834009ENST0000035519358603391_34334938.04969.0Coiled coilOntology_term=ECO:0000255
TgeneKMT2Cchr7:151329155chr7:151834009ENST000003551935860644_6724938.04969.0Coiled coilOntology_term=ECO:0000255
TgeneKMT2Cchr7:151329155chr7:151834009ENST00000355193586092_1124938.04969.0Coiled coilOntology_term=ECO:0000255
TgeneKMT2Cchr7:151372506chr7:151860911ENST0000026218941591338_13663250.04912.0Coiled coilOntology_term=ECO:0000255
TgeneKMT2Cchr7:151372506chr7:151860911ENST0000026218941591754_17873250.04912.0Coiled coilOntology_term=ECO:0000255
TgeneKMT2Cchr7:151372506chr7:151860911ENST0000026218941593054_30813250.04912.0Coiled coilOntology_term=ECO:0000255
TgeneKMT2Cchr7:151372506chr7:151860911ENST0000026218941593173_32723250.04912.0Coiled coilOntology_term=ECO:0000255
TgeneKMT2Cchr7:151372506chr7:151860911ENST000002621894159644_6723250.04912.0Coiled coilOntology_term=ECO:0000255
TgeneKMT2Cchr7:151372506chr7:151860911ENST00000262189415992_1123250.04912.0Coiled coilOntology_term=ECO:0000255
TgeneKMT2Cchr7:151372506chr7:151860911ENST0000035519341601338_13663250.04969.0Coiled coilOntology_term=ECO:0000255
TgeneKMT2Cchr7:151372506chr7:151860911ENST0000035519341601754_17873250.04969.0Coiled coilOntology_term=ECO:0000255
TgeneKMT2Cchr7:151372506chr7:151860911ENST0000035519341603054_30813250.04969.0Coiled coilOntology_term=ECO:0000255
TgeneKMT2Cchr7:151372506chr7:151860911ENST0000035519341603173_32723250.04969.0Coiled coilOntology_term=ECO:0000255
TgeneKMT2Cchr7:151372506chr7:151860911ENST000003551934160644_6723250.04969.0Coiled coilOntology_term=ECO:0000255
TgeneKMT2Cchr7:151372506chr7:151860911ENST00000355193416092_1123250.04969.0Coiled coilOntology_term=ECO:0000255
TgeneKMT2Cchr7:151329155chr7:151834009ENST0000026218957591719_17964881.04912.0Compositional biasNote=Gln-rich
TgeneKMT2Cchr7:151329155chr7:151834009ENST0000026218957591834_22814881.04912.0Compositional biasNote=Pro-rich
TgeneKMT2Cchr7:151329155chr7:151834009ENST0000026218957592412_26304881.04912.0Compositional biasNote=Pro-rich
TgeneKMT2Cchr7:151329155chr7:151834009ENST0000026218957592690_27864881.04912.0Compositional biasNote=Asp-rich
TgeneKMT2Cchr7:151329155chr7:151834009ENST0000026218957593012_35094881.04912.0Compositional biasNote=Gln-rich
TgeneKMT2Cchr7:151329155chr7:151834009ENST0000026218957593277_33814881.04912.0Compositional biasNote=Pro-rich
TgeneKMT2Cchr7:151329155chr7:151834009ENST0000035519358601719_17964938.04969.0Compositional biasNote=Gln-rich
TgeneKMT2Cchr7:151329155chr7:151834009ENST0000035519358601834_22814938.04969.0Compositional biasNote=Pro-rich
TgeneKMT2Cchr7:151329155chr7:151834009ENST0000035519358602412_26304938.04969.0Compositional biasNote=Pro-rich
TgeneKMT2Cchr7:151329155chr7:151834009ENST0000035519358602690_27864938.04969.0Compositional biasNote=Asp-rich
TgeneKMT2Cchr7:151329155chr7:151834009ENST0000035519358603012_35094938.04969.0Compositional biasNote=Gln-rich
TgeneKMT2Cchr7:151329155chr7:151834009ENST0000035519358603277_33814938.04969.0Compositional biasNote=Pro-rich
TgeneKMT2Cchr7:151372506chr7:151860911ENST0000026218941591719_17963250.04912.0Compositional biasNote=Gln-rich
TgeneKMT2Cchr7:151372506chr7:151860911ENST0000026218941591834_22813250.04912.0Compositional biasNote=Pro-rich
TgeneKMT2Cchr7:151372506chr7:151860911ENST0000026218941592412_26303250.04912.0Compositional biasNote=Pro-rich
TgeneKMT2Cchr7:151372506chr7:151860911ENST0000026218941592690_27863250.04912.0Compositional biasNote=Asp-rich
TgeneKMT2Cchr7:151372506chr7:151860911ENST0000026218941593012_35093250.04912.0Compositional biasNote=Gln-rich
TgeneKMT2Cchr7:151372506chr7:151860911ENST0000035519341601719_17963250.04969.0Compositional biasNote=Gln-rich
TgeneKMT2Cchr7:151372506chr7:151860911ENST0000035519341601834_22813250.04969.0Compositional biasNote=Pro-rich
TgeneKMT2Cchr7:151372506chr7:151860911ENST0000035519341602412_26303250.04969.0Compositional biasNote=Pro-rich
TgeneKMT2Cchr7:151372506chr7:151860911ENST0000035519341602690_27863250.04969.0Compositional biasNote=Asp-rich
TgeneKMT2Cchr7:151372506chr7:151860911ENST0000035519341603012_35093250.04969.0Compositional biasNote=Gln-rich
TgeneKMT2Cchr7:151329155chr7:151834009ENST00000262189575934_464881.04912.0DNA bindingNote=A.T hook
TgeneKMT2Cchr7:151329155chr7:151834009ENST00000355193586034_464938.04969.0DNA bindingNote=A.T hook
TgeneKMT2Cchr7:151372506chr7:151860911ENST00000262189415934_463250.04912.0DNA bindingNote=A.T hook
TgeneKMT2Cchr7:151372506chr7:151860911ENST00000355193416034_463250.04969.0DNA bindingNote=A.T hook
TgeneKMT2Cchr7:151329155chr7:151834009ENST000002621895759436_4894881.04912.0DomainDHHC
TgeneKMT2Cchr7:151329155chr7:151834009ENST0000026218957594545_46054881.04912.0DomainFYR N-terminal
TgeneKMT2Cchr7:151329155chr7:151834009ENST0000026218957594606_46914881.04912.0DomainFYR C-terminal
TgeneKMT2Cchr7:151329155chr7:151834009ENST0000026218957594771_48874881.04912.0DomainSET
TgeneKMT2Cchr7:151329155chr7:151834009ENST000003551935860436_4894938.04969.0DomainDHHC
TgeneKMT2Cchr7:151329155chr7:151834009ENST0000035519358604545_46054938.04969.0DomainFYR N-terminal
TgeneKMT2Cchr7:151329155chr7:151834009ENST0000035519358604606_46914938.04969.0DomainFYR C-terminal
TgeneKMT2Cchr7:151329155chr7:151834009ENST0000035519358604771_48874938.04969.0DomainSET
TgeneKMT2Cchr7:151329155chr7:151834009ENST0000035519358604895_49114938.04969.0DomainPost-SET
TgeneKMT2Cchr7:151372506chr7:151860911ENST000002621894159436_4893250.04912.0DomainDHHC
TgeneKMT2Cchr7:151372506chr7:151860911ENST000003551934160436_4893250.04969.0DomainDHHC
TgeneKMT2Cchr7:151329155chr7:151834009ENST0000026218957594848_48494881.04912.0RegionS-adenosyl-L-methionine binding
TgeneKMT2Cchr7:151329155chr7:151834009ENST0000035519358604848_48494938.04969.0RegionS-adenosyl-L-methionine binding
TgeneKMT2Cchr7:151329155chr7:151834009ENST0000026218957591007_10574881.04912.0Zinc fingerPHD-type 6
TgeneKMT2Cchr7:151329155chr7:151834009ENST0000026218957591084_11394881.04912.0Zinc fingerPHD-type 7
TgeneKMT2Cchr7:151329155chr7:151834009ENST000002621895759227_2624881.04912.0Zinc fingerC2HC pre-PHD-type 1%3B degenerate
TgeneKMT2Cchr7:151329155chr7:151834009ENST000002621895759283_3314881.04912.0Zinc fingerPHD-type 1
TgeneKMT2Cchr7:151329155chr7:151834009ENST000002621895759341_3914881.04912.0Zinc fingerPHD-type 2
TgeneKMT2Cchr7:151329155chr7:151834009ENST000002621895759344_3894881.04912.0Zinc fingerRING-type
TgeneKMT2Cchr7:151329155chr7:151834009ENST000002621895759388_4384881.04912.0Zinc fingerPHD-type 3
TgeneKMT2Cchr7:151329155chr7:151834009ENST0000026218957594399_44394881.04912.0Zinc fingerC2HC pre-PHD-type 2
TgeneKMT2Cchr7:151329155chr7:151834009ENST0000026218957594460_45074881.04912.0Zinc fingerPHD-type 8
TgeneKMT2Cchr7:151329155chr7:151834009ENST000002621895759464_5204881.04912.0Zinc fingerPHD-type 4
TgeneKMT2Cchr7:151329155chr7:151834009ENST000002621895759957_10104881.04912.0Zinc fingerPHD-type 5
TgeneKMT2Cchr7:151329155chr7:151834009ENST0000035519358601007_10574938.04969.0Zinc fingerPHD-type 6
TgeneKMT2Cchr7:151329155chr7:151834009ENST0000035519358601084_11394938.04969.0Zinc fingerPHD-type 7
TgeneKMT2Cchr7:151329155chr7:151834009ENST000003551935860227_2624938.04969.0Zinc fingerC2HC pre-PHD-type 1%3B degenerate
TgeneKMT2Cchr7:151329155chr7:151834009ENST000003551935860283_3314938.04969.0Zinc fingerPHD-type 1
TgeneKMT2Cchr7:151329155chr7:151834009ENST000003551935860341_3914938.04969.0Zinc fingerPHD-type 2
TgeneKMT2Cchr7:151329155chr7:151834009ENST000003551935860344_3894938.04969.0Zinc fingerRING-type
TgeneKMT2Cchr7:151329155chr7:151834009ENST000003551935860388_4384938.04969.0Zinc fingerPHD-type 3
TgeneKMT2Cchr7:151329155chr7:151834009ENST0000035519358604399_44394938.04969.0Zinc fingerC2HC pre-PHD-type 2
TgeneKMT2Cchr7:151329155chr7:151834009ENST0000035519358604460_45074938.04969.0Zinc fingerPHD-type 8
TgeneKMT2Cchr7:151329155chr7:151834009ENST000003551935860464_5204938.04969.0Zinc fingerPHD-type 4
TgeneKMT2Cchr7:151329155chr7:151834009ENST000003551935860957_10104938.04969.0Zinc fingerPHD-type 5
TgeneKMT2Cchr7:151372506chr7:151860911ENST0000026218941591007_10573250.04912.0Zinc fingerPHD-type 6
TgeneKMT2Cchr7:151372506chr7:151860911ENST0000026218941591084_11393250.04912.0Zinc fingerPHD-type 7
TgeneKMT2Cchr7:151372506chr7:151860911ENST000002621894159227_2623250.04912.0Zinc fingerC2HC pre-PHD-type 1%3B degenerate
TgeneKMT2Cchr7:151372506chr7:151860911ENST000002621894159283_3313250.04912.0Zinc fingerPHD-type 1
TgeneKMT2Cchr7:151372506chr7:151860911ENST000002621894159341_3913250.04912.0Zinc fingerPHD-type 2
TgeneKMT2Cchr7:151372506chr7:151860911ENST000002621894159344_3893250.04912.0Zinc fingerRING-type
TgeneKMT2Cchr7:151372506chr7:151860911ENST000002621894159388_4383250.04912.0Zinc fingerPHD-type 3
TgeneKMT2Cchr7:151372506chr7:151860911ENST000002621894159464_5203250.04912.0Zinc fingerPHD-type 4
TgeneKMT2Cchr7:151372506chr7:151860911ENST000002621894159957_10103250.04912.0Zinc fingerPHD-type 5
TgeneKMT2Cchr7:151372506chr7:151860911ENST0000035519341601007_10573250.04969.0Zinc fingerPHD-type 6
TgeneKMT2Cchr7:151372506chr7:151860911ENST0000035519341601084_11393250.04969.0Zinc fingerPHD-type 7
TgeneKMT2Cchr7:151372506chr7:151860911ENST000003551934160227_2623250.04969.0Zinc fingerC2HC pre-PHD-type 1%3B degenerate
TgeneKMT2Cchr7:151372506chr7:151860911ENST000003551934160283_3313250.04969.0Zinc fingerPHD-type 1
TgeneKMT2Cchr7:151372506chr7:151860911ENST000003551934160341_3913250.04969.0Zinc fingerPHD-type 2
TgeneKMT2Cchr7:151372506chr7:151860911ENST000003551934160344_3893250.04969.0Zinc fingerRING-type
TgeneKMT2Cchr7:151372506chr7:151860911ENST000003551934160388_4383250.04969.0Zinc fingerPHD-type 3
TgeneKMT2Cchr7:151372506chr7:151860911ENST000003551934160464_5203250.04969.0Zinc fingerPHD-type 4
TgeneKMT2Cchr7:151372506chr7:151860911ENST000003551934160957_10103250.04969.0Zinc fingerPHD-type 5


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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
PRKAG2
KMT2C


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to PRKAG2-KMT2C


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to PRKAG2-KMT2C


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource