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Fusion Protein:PRKAR2A-CACNA2D3 |
Fusion Protein Summary |
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Fusion partner gene information | Fusion gene name: PRKAR2A-CACNA2D3 | FusionPDB ID: 68675 | FusionGDB2.0 ID: 68675 | Hgene | Tgene | Gene symbol | PRKAR2A | CACNA2D3 | Gene ID | 5576 | 55799 |
Gene name | protein kinase cAMP-dependent type II regulatory subunit alpha | calcium voltage-gated channel auxiliary subunit alpha2delta 3 | |
Synonyms | PKR2|PRKAR2 | HSA272268 | |
Cytomap | 3p21.31 | 3p21.1-p14.3 | |
Type of gene | protein-coding | protein-coding | |
Description | cAMP-dependent protein kinase type II-alpha regulatory subunitcAMP-dependent protein kinase regulatory subunit RII alphaprotein kinase A, RII-alpha subunitprotein kinase, cAMP-dependent, regulatory subunit type II alpha | voltage-dependent calcium channel subunit alpha-2/delta-3calcium channel alpha2-delta3 subunitcalcium channel, voltage-dependent, alpha 2/delta 3 subunitcalcium channel, voltage-dependent, alpha 2/delta subunit 3voltage-gated calcium channel subunit a | |
Modification date | 20200313 | 20200313 | |
UniProtAcc | P13861 | Q8IZS8 | |
Ensembl transtripts involved in fusion gene | ENST ids | ENST00000265563, ENST00000296446, ENST00000454963, | ENST00000478261, ENST00000288197, ENST00000415676, ENST00000474759, ENST00000490478, |
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0) | * DoF score | 11 X 7 X 7=539 | 16 X 13 X 9=1872 |
# samples | 11 | 16 | |
** MAII score | log2(11/539*10)=-2.29278174922785 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(16/1872*10)=-3.54843662469604 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context (manual curation of fusion genes in FusionPDB) | PubMed: PRKAR2A [Title/Abstract] AND CACNA2D3 [Title/Abstract] AND fusion [Title/Abstract] | ||
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0) | PRKAR2A(48884768)-CACNA2D3(54537519), # samples:3 | ||
Anticipated loss of major functional domain due to fusion event. | PRKAR2A-CACNA2D3 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. PRKAR2A-CACNA2D3 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. PRKAR2A-CACNA2D3 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. PRKAR2A-CACNA2D3 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | PRKAR2A | GO:2000480 | negative regulation of cAMP-dependent protein kinase activity | 21812984 |
![]() * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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![]() * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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Fusion Gene Sample Information |
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![]() * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChimerDB4 | THYM | TCGA-ZB-A96L-01A | PRKAR2A | chr3 | 48884768 | - | CACNA2D3 | chr3 | 54537519 | + |
ChimerDB4 | THYM | TCGA-ZB-A96L | PRKAR2A | chr3 | 48884768 | - | CACNA2D3 | chr3 | 54537519 | + |
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Fusion ORF Analysis |
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Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
ENST00000265563 | PRKAR2A | chr3 | 48884768 | - | ENST00000415676 | CACNA2D3 | chr3 | 54537519 | + | 3674 | 512 | 329 | 3406 | 1025 |
ENST00000265563 | PRKAR2A | chr3 | 48884768 | - | ENST00000288197 | CACNA2D3 | chr3 | 54537519 | + | 3754 | 512 | 329 | 3406 | 1025 |
ENST00000265563 | PRKAR2A | chr3 | 48884768 | - | ENST00000474759 | CACNA2D3 | chr3 | 54537519 | + | 3758 | 512 | 329 | 3406 | 1025 |
ENST00000265563 | PRKAR2A | chr3 | 48884768 | - | ENST00000490478 | CACNA2D3 | chr3 | 54537519 | + | 3758 | 512 | 329 | 3406 | 1025 |
ENST00000454963 | PRKAR2A | chr3 | 48884768 | - | ENST00000415676 | CACNA2D3 | chr3 | 54537519 | + | 3632 | 470 | 287 | 3364 | 1025 |
ENST00000454963 | PRKAR2A | chr3 | 48884768 | - | ENST00000288197 | CACNA2D3 | chr3 | 54537519 | + | 3712 | 470 | 287 | 3364 | 1025 |
ENST00000454963 | PRKAR2A | chr3 | 48884768 | - | ENST00000474759 | CACNA2D3 | chr3 | 54537519 | + | 3716 | 470 | 287 | 3364 | 1025 |
ENST00000454963 | PRKAR2A | chr3 | 48884768 | - | ENST00000490478 | CACNA2D3 | chr3 | 54537519 | + | 3716 | 470 | 287 | 3364 | 1025 |
ENST00000296446 | PRKAR2A | chr3 | 48884768 | - | ENST00000415676 | CACNA2D3 | chr3 | 54537519 | + | 3656 | 494 | 311 | 3388 | 1025 |
ENST00000296446 | PRKAR2A | chr3 | 48884768 | - | ENST00000288197 | CACNA2D3 | chr3 | 54537519 | + | 3736 | 494 | 311 | 3388 | 1025 |
ENST00000296446 | PRKAR2A | chr3 | 48884768 | - | ENST00000474759 | CACNA2D3 | chr3 | 54537519 | + | 3740 | 494 | 311 | 3388 | 1025 |
ENST00000296446 | PRKAR2A | chr3 | 48884768 | - | ENST00000490478 | CACNA2D3 | chr3 | 54537519 | + | 3740 | 494 | 311 | 3388 | 1025 |
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Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
ENST00000265563 | ENST00000415676 | PRKAR2A | chr3 | 48884768 | - | CACNA2D3 | chr3 | 54537519 | + | 0.001030044 | 0.9989699 |
ENST00000265563 | ENST00000288197 | PRKAR2A | chr3 | 48884768 | - | CACNA2D3 | chr3 | 54537519 | + | 0.000893213 | 0.9991067 |
ENST00000265563 | ENST00000474759 | PRKAR2A | chr3 | 48884768 | - | CACNA2D3 | chr3 | 54537519 | + | 0.000889663 | 0.9991103 |
ENST00000265563 | ENST00000490478 | PRKAR2A | chr3 | 48884768 | - | CACNA2D3 | chr3 | 54537519 | + | 0.000889663 | 0.9991103 |
ENST00000454963 | ENST00000415676 | PRKAR2A | chr3 | 48884768 | - | CACNA2D3 | chr3 | 54537519 | + | 0.000996187 | 0.9990038 |
ENST00000454963 | ENST00000288197 | PRKAR2A | chr3 | 48884768 | - | CACNA2D3 | chr3 | 54537519 | + | 0.000866235 | 0.99913377 |
ENST00000454963 | ENST00000474759 | PRKAR2A | chr3 | 48884768 | - | CACNA2D3 | chr3 | 54537519 | + | 0.000863002 | 0.999137 |
ENST00000454963 | ENST00000490478 | PRKAR2A | chr3 | 48884768 | - | CACNA2D3 | chr3 | 54537519 | + | 0.000863002 | 0.999137 |
ENST00000296446 | ENST00000415676 | PRKAR2A | chr3 | 48884768 | - | CACNA2D3 | chr3 | 54537519 | + | 0.001018355 | 0.99898165 |
ENST00000296446 | ENST00000288197 | PRKAR2A | chr3 | 48884768 | - | CACNA2D3 | chr3 | 54537519 | + | 0.000885741 | 0.9991142 |
ENST00000296446 | ENST00000474759 | PRKAR2A | chr3 | 48884768 | - | CACNA2D3 | chr3 | 54537519 | + | 0.000882307 | 0.9991177 |
ENST00000296446 | ENST00000490478 | PRKAR2A | chr3 | 48884768 | - | CACNA2D3 | chr3 | 54537519 | + | 0.000882307 | 0.9991177 |
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Fusion Amino Acid Sequences |
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>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP >68675_68675_1_PRKAR2A-CACNA2D3_PRKAR2A_chr3_48884768_ENST00000265563_CACNA2D3_chr3_54537519_ENST00000288197_length(amino acids)=1025AA_BP=61 MTSSNSQWSTSPACARPAPQPQSCPPPPHARAWATPRQNPARTVSPTPKGTASRRRTRTWKYEYFNAVLINERDKDGNFLELGKEFILAP NDHFNNLPVNISLSDVQVPTNMYNKDPAIVNGVYWSESLNKVFVDNFDRDPSLIWQYFGSAKGFFRQYPGIKWEPDENGVIAFDCRNRKW YIQAATSPKDVVILVDVSGSMKGLRLTIAKQTVSSILDTLGDDDFFNIIAYNEELHYVEPCLNGTLVQADRTNKEHFREHLDKLFAKGIG MLDIALNEAFNILSDFNHTGQGSICSQAIMLITDGAVDTYDTIFAKYNWPDRKVRIFTYLIGREAAFADNLKWMACANKGFFTQISTLAD VQENVMEYLHVLSRPKVIDQEHDVVWTEAYIDSTLPQAQKLTDDQGPVLMTTVAMPVFSKQNETRSKGILLGVVGTDVPVKELLKTIPKY KLGIHGYAFAITNNGYILTHPELRLLYEEGKKRRKPNYSSVDLSEVEWEDRDDVLRNAMVNRKTGKFSMEVKKTVDKGKRVLVMTNDYYY TDIKGTPFSLGVALSRGHGKYFFRGNVTIEEGLHDLEHPDVSLADEWSYCNTDLHPEHRHLSQLEAIKLYLKGKEPLLQCDKELIQEVLF DAVVSAPIEAYWTSLALNKSENSDKGVEVAFLGTRTGLSRINLFVGAEQLTNQDFLKAGDKENIFNADHFPLWYRRAAEQIPGSFVYSIP FSTGPVNKSNVVTASTSIQLLDERKSPVVAAVGIQMKLEFFQRKFWTASRQCASLDGKCSISCDDETVNCYLIDNNGFILVSEDYTQTGD FFGEIEGAVMNKLLTMGSFKRITLYDYQAMCRANKESSDGAHGLLDPYNAFLSAVKWIMTELVLFLVEFNLCSWWHSDMTAKAQKLKQTL EPCDTEYPAFVSERTIKETTGNIACEDCSKSFVIQQIPSSNLFMVVVDSSCLCESVAPITMAPIEIRYNESLKCERLKAQKIRRRPESCH -------------------------------------------------------------- >68675_68675_2_PRKAR2A-CACNA2D3_PRKAR2A_chr3_48884768_ENST00000265563_CACNA2D3_chr3_54537519_ENST00000415676_length(amino acids)=1025AA_BP=61 MTSSNSQWSTSPACARPAPQPQSCPPPPHARAWATPRQNPARTVSPTPKGTASRRRTRTWKYEYFNAVLINERDKDGNFLELGKEFILAP NDHFNNLPVNISLSDVQVPTNMYNKDPAIVNGVYWSESLNKVFVDNFDRDPSLIWQYFGSAKGFFRQYPGIKWEPDENGVIAFDCRNRKW YIQAATSPKDVVILVDVSGSMKGLRLTIAKQTVSSILDTLGDDDFFNIIAYNEELHYVEPCLNGTLVQADRTNKEHFREHLDKLFAKGIG MLDIALNEAFNILSDFNHTGQGSICSQAIMLITDGAVDTYDTIFAKYNWPDRKVRIFTYLIGREAAFADNLKWMACANKGFFTQISTLAD VQENVMEYLHVLSRPKVIDQEHDVVWTEAYIDSTLPQAQKLTDDQGPVLMTTVAMPVFSKQNETRSKGILLGVVGTDVPVKELLKTIPKY KLGIHGYAFAITNNGYILTHPELRLLYEEGKKRRKPNYSSVDLSEVEWEDRDDVLRNAMVNRKTGKFSMEVKKTVDKGKRVLVMTNDYYY TDIKGTPFSLGVALSRGHGKYFFRGNVTIEEGLHDLEHPDVSLADEWSYCNTDLHPEHRHLSQLEAIKLYLKGKEPLLQCDKELIQEVLF DAVVSAPIEAYWTSLALNKSENSDKGVEVAFLGTRTGLSRINLFVGAEQLTNQDFLKAGDKENIFNADHFPLWYRRAAEQIPGSFVYSIP FSTGPVNKSNVVTASTSIQLLDERKSPVVAAVGIQMKLEFFQRKFWTASRQCASLDGKCSISCDDETVNCYLIDNNGFILVSEDYTQTGD FFGEIEGAVMNKLLTMGSFKRITLYDYQAMCRANKESSDGAHGLLDPYNAFLSAVKWIMTELVLFLVEFNLCSWWHSDMTAKAQKLKQTL EPCDTEYPAFVSERTIKETTGNIACEDCSKSFVIQQIPSSNLFMVVVDSSCLCESVAPITMAPIEIRYNESLKCERLKAQKIRRRPESCH -------------------------------------------------------------- >68675_68675_3_PRKAR2A-CACNA2D3_PRKAR2A_chr3_48884768_ENST00000265563_CACNA2D3_chr3_54537519_ENST00000474759_length(amino acids)=1025AA_BP=61 MTSSNSQWSTSPACARPAPQPQSCPPPPHARAWATPRQNPARTVSPTPKGTASRRRTRTWKYEYFNAVLINERDKDGNFLELGKEFILAP NDHFNNLPVNISLSDVQVPTNMYNKDPAIVNGVYWSESLNKVFVDNFDRDPSLIWQYFGSAKGFFRQYPGIKWEPDENGVIAFDCRNRKW YIQAATSPKDVVILVDVSGSMKGLRLTIAKQTVSSILDTLGDDDFFNIIAYNEELHYVEPCLNGTLVQADRTNKEHFREHLDKLFAKGIG MLDIALNEAFNILSDFNHTGQGSICSQAIMLITDGAVDTYDTIFAKYNWPDRKVRIFTYLIGREAAFADNLKWMACANKGFFTQISTLAD VQENVMEYLHVLSRPKVIDQEHDVVWTEAYIDSTLPQAQKLTDDQGPVLMTTVAMPVFSKQNETRSKGILLGVVGTDVPVKELLKTIPKY KLGIHGYAFAITNNGYILTHPELRLLYEEGKKRRKPNYSSVDLSEVEWEDRDDVLRNAMVNRKTGKFSMEVKKTVDKGKRVLVMTNDYYY TDIKGTPFSLGVALSRGHGKYFFRGNVTIEEGLHDLEHPDVSLADEWSYCNTDLHPEHRHLSQLEAIKLYLKGKEPLLQCDKELIQEVLF DAVVSAPIEAYWTSLALNKSENSDKGVEVAFLGTRTGLSRINLFVGAEQLTNQDFLKAGDKENIFNADHFPLWYRRAAEQIPGSFVYSIP FSTGPVNKSNVVTASTSIQLLDERKSPVVAAVGIQMKLEFFQRKFWTASRQCASLDGKCSISCDDETVNCYLIDNNGFILVSEDYTQTGD FFGEIEGAVMNKLLTMGSFKRITLYDYQAMCRANKESSDGAHGLLDPYNAFLSAVKWIMTELVLFLVEFNLCSWWHSDMTAKAQKLKQTL EPCDTEYPAFVSERTIKETTGNIACEDCSKSFVIQQIPSSNLFMVVVDSSCLCESVAPITMAPIEIRYNESLKCERLKAQKIRRRPESCH -------------------------------------------------------------- >68675_68675_4_PRKAR2A-CACNA2D3_PRKAR2A_chr3_48884768_ENST00000265563_CACNA2D3_chr3_54537519_ENST00000490478_length(amino acids)=1025AA_BP=61 MTSSNSQWSTSPACARPAPQPQSCPPPPHARAWATPRQNPARTVSPTPKGTASRRRTRTWKYEYFNAVLINERDKDGNFLELGKEFILAP NDHFNNLPVNISLSDVQVPTNMYNKDPAIVNGVYWSESLNKVFVDNFDRDPSLIWQYFGSAKGFFRQYPGIKWEPDENGVIAFDCRNRKW YIQAATSPKDVVILVDVSGSMKGLRLTIAKQTVSSILDTLGDDDFFNIIAYNEELHYVEPCLNGTLVQADRTNKEHFREHLDKLFAKGIG MLDIALNEAFNILSDFNHTGQGSICSQAIMLITDGAVDTYDTIFAKYNWPDRKVRIFTYLIGREAAFADNLKWMACANKGFFTQISTLAD VQENVMEYLHVLSRPKVIDQEHDVVWTEAYIDSTLPQAQKLTDDQGPVLMTTVAMPVFSKQNETRSKGILLGVVGTDVPVKELLKTIPKY KLGIHGYAFAITNNGYILTHPELRLLYEEGKKRRKPNYSSVDLSEVEWEDRDDVLRNAMVNRKTGKFSMEVKKTVDKGKRVLVMTNDYYY TDIKGTPFSLGVALSRGHGKYFFRGNVTIEEGLHDLEHPDVSLADEWSYCNTDLHPEHRHLSQLEAIKLYLKGKEPLLQCDKELIQEVLF DAVVSAPIEAYWTSLALNKSENSDKGVEVAFLGTRTGLSRINLFVGAEQLTNQDFLKAGDKENIFNADHFPLWYRRAAEQIPGSFVYSIP FSTGPVNKSNVVTASTSIQLLDERKSPVVAAVGIQMKLEFFQRKFWTASRQCASLDGKCSISCDDETVNCYLIDNNGFILVSEDYTQTGD FFGEIEGAVMNKLLTMGSFKRITLYDYQAMCRANKESSDGAHGLLDPYNAFLSAVKWIMTELVLFLVEFNLCSWWHSDMTAKAQKLKQTL EPCDTEYPAFVSERTIKETTGNIACEDCSKSFVIQQIPSSNLFMVVVDSSCLCESVAPITMAPIEIRYNESLKCERLKAQKIRRRPESCH -------------------------------------------------------------- >68675_68675_5_PRKAR2A-CACNA2D3_PRKAR2A_chr3_48884768_ENST00000296446_CACNA2D3_chr3_54537519_ENST00000288197_length(amino acids)=1025AA_BP=61 MTSSNSQWSTSPACARPAPQPQSCPPPPHARAWATPRQNPARTVSPTPKGTASRRRTRTWKYEYFNAVLINERDKDGNFLELGKEFILAP NDHFNNLPVNISLSDVQVPTNMYNKDPAIVNGVYWSESLNKVFVDNFDRDPSLIWQYFGSAKGFFRQYPGIKWEPDENGVIAFDCRNRKW YIQAATSPKDVVILVDVSGSMKGLRLTIAKQTVSSILDTLGDDDFFNIIAYNEELHYVEPCLNGTLVQADRTNKEHFREHLDKLFAKGIG MLDIALNEAFNILSDFNHTGQGSICSQAIMLITDGAVDTYDTIFAKYNWPDRKVRIFTYLIGREAAFADNLKWMACANKGFFTQISTLAD VQENVMEYLHVLSRPKVIDQEHDVVWTEAYIDSTLPQAQKLTDDQGPVLMTTVAMPVFSKQNETRSKGILLGVVGTDVPVKELLKTIPKY KLGIHGYAFAITNNGYILTHPELRLLYEEGKKRRKPNYSSVDLSEVEWEDRDDVLRNAMVNRKTGKFSMEVKKTVDKGKRVLVMTNDYYY TDIKGTPFSLGVALSRGHGKYFFRGNVTIEEGLHDLEHPDVSLADEWSYCNTDLHPEHRHLSQLEAIKLYLKGKEPLLQCDKELIQEVLF DAVVSAPIEAYWTSLALNKSENSDKGVEVAFLGTRTGLSRINLFVGAEQLTNQDFLKAGDKENIFNADHFPLWYRRAAEQIPGSFVYSIP FSTGPVNKSNVVTASTSIQLLDERKSPVVAAVGIQMKLEFFQRKFWTASRQCASLDGKCSISCDDETVNCYLIDNNGFILVSEDYTQTGD FFGEIEGAVMNKLLTMGSFKRITLYDYQAMCRANKESSDGAHGLLDPYNAFLSAVKWIMTELVLFLVEFNLCSWWHSDMTAKAQKLKQTL EPCDTEYPAFVSERTIKETTGNIACEDCSKSFVIQQIPSSNLFMVVVDSSCLCESVAPITMAPIEIRYNESLKCERLKAQKIRRRPESCH -------------------------------------------------------------- >68675_68675_6_PRKAR2A-CACNA2D3_PRKAR2A_chr3_48884768_ENST00000296446_CACNA2D3_chr3_54537519_ENST00000415676_length(amino acids)=1025AA_BP=61 MTSSNSQWSTSPACARPAPQPQSCPPPPHARAWATPRQNPARTVSPTPKGTASRRRTRTWKYEYFNAVLINERDKDGNFLELGKEFILAP NDHFNNLPVNISLSDVQVPTNMYNKDPAIVNGVYWSESLNKVFVDNFDRDPSLIWQYFGSAKGFFRQYPGIKWEPDENGVIAFDCRNRKW YIQAATSPKDVVILVDVSGSMKGLRLTIAKQTVSSILDTLGDDDFFNIIAYNEELHYVEPCLNGTLVQADRTNKEHFREHLDKLFAKGIG MLDIALNEAFNILSDFNHTGQGSICSQAIMLITDGAVDTYDTIFAKYNWPDRKVRIFTYLIGREAAFADNLKWMACANKGFFTQISTLAD VQENVMEYLHVLSRPKVIDQEHDVVWTEAYIDSTLPQAQKLTDDQGPVLMTTVAMPVFSKQNETRSKGILLGVVGTDVPVKELLKTIPKY KLGIHGYAFAITNNGYILTHPELRLLYEEGKKRRKPNYSSVDLSEVEWEDRDDVLRNAMVNRKTGKFSMEVKKTVDKGKRVLVMTNDYYY TDIKGTPFSLGVALSRGHGKYFFRGNVTIEEGLHDLEHPDVSLADEWSYCNTDLHPEHRHLSQLEAIKLYLKGKEPLLQCDKELIQEVLF DAVVSAPIEAYWTSLALNKSENSDKGVEVAFLGTRTGLSRINLFVGAEQLTNQDFLKAGDKENIFNADHFPLWYRRAAEQIPGSFVYSIP FSTGPVNKSNVVTASTSIQLLDERKSPVVAAVGIQMKLEFFQRKFWTASRQCASLDGKCSISCDDETVNCYLIDNNGFILVSEDYTQTGD FFGEIEGAVMNKLLTMGSFKRITLYDYQAMCRANKESSDGAHGLLDPYNAFLSAVKWIMTELVLFLVEFNLCSWWHSDMTAKAQKLKQTL EPCDTEYPAFVSERTIKETTGNIACEDCSKSFVIQQIPSSNLFMVVVDSSCLCESVAPITMAPIEIRYNESLKCERLKAQKIRRRPESCH -------------------------------------------------------------- >68675_68675_7_PRKAR2A-CACNA2D3_PRKAR2A_chr3_48884768_ENST00000296446_CACNA2D3_chr3_54537519_ENST00000474759_length(amino acids)=1025AA_BP=61 MTSSNSQWSTSPACARPAPQPQSCPPPPHARAWATPRQNPARTVSPTPKGTASRRRTRTWKYEYFNAVLINERDKDGNFLELGKEFILAP NDHFNNLPVNISLSDVQVPTNMYNKDPAIVNGVYWSESLNKVFVDNFDRDPSLIWQYFGSAKGFFRQYPGIKWEPDENGVIAFDCRNRKW YIQAATSPKDVVILVDVSGSMKGLRLTIAKQTVSSILDTLGDDDFFNIIAYNEELHYVEPCLNGTLVQADRTNKEHFREHLDKLFAKGIG MLDIALNEAFNILSDFNHTGQGSICSQAIMLITDGAVDTYDTIFAKYNWPDRKVRIFTYLIGREAAFADNLKWMACANKGFFTQISTLAD VQENVMEYLHVLSRPKVIDQEHDVVWTEAYIDSTLPQAQKLTDDQGPVLMTTVAMPVFSKQNETRSKGILLGVVGTDVPVKELLKTIPKY KLGIHGYAFAITNNGYILTHPELRLLYEEGKKRRKPNYSSVDLSEVEWEDRDDVLRNAMVNRKTGKFSMEVKKTVDKGKRVLVMTNDYYY TDIKGTPFSLGVALSRGHGKYFFRGNVTIEEGLHDLEHPDVSLADEWSYCNTDLHPEHRHLSQLEAIKLYLKGKEPLLQCDKELIQEVLF DAVVSAPIEAYWTSLALNKSENSDKGVEVAFLGTRTGLSRINLFVGAEQLTNQDFLKAGDKENIFNADHFPLWYRRAAEQIPGSFVYSIP FSTGPVNKSNVVTASTSIQLLDERKSPVVAAVGIQMKLEFFQRKFWTASRQCASLDGKCSISCDDETVNCYLIDNNGFILVSEDYTQTGD FFGEIEGAVMNKLLTMGSFKRITLYDYQAMCRANKESSDGAHGLLDPYNAFLSAVKWIMTELVLFLVEFNLCSWWHSDMTAKAQKLKQTL EPCDTEYPAFVSERTIKETTGNIACEDCSKSFVIQQIPSSNLFMVVVDSSCLCESVAPITMAPIEIRYNESLKCERLKAQKIRRRPESCH -------------------------------------------------------------- >68675_68675_8_PRKAR2A-CACNA2D3_PRKAR2A_chr3_48884768_ENST00000296446_CACNA2D3_chr3_54537519_ENST00000490478_length(amino acids)=1025AA_BP=61 MTSSNSQWSTSPACARPAPQPQSCPPPPHARAWATPRQNPARTVSPTPKGTASRRRTRTWKYEYFNAVLINERDKDGNFLELGKEFILAP NDHFNNLPVNISLSDVQVPTNMYNKDPAIVNGVYWSESLNKVFVDNFDRDPSLIWQYFGSAKGFFRQYPGIKWEPDENGVIAFDCRNRKW YIQAATSPKDVVILVDVSGSMKGLRLTIAKQTVSSILDTLGDDDFFNIIAYNEELHYVEPCLNGTLVQADRTNKEHFREHLDKLFAKGIG MLDIALNEAFNILSDFNHTGQGSICSQAIMLITDGAVDTYDTIFAKYNWPDRKVRIFTYLIGREAAFADNLKWMACANKGFFTQISTLAD VQENVMEYLHVLSRPKVIDQEHDVVWTEAYIDSTLPQAQKLTDDQGPVLMTTVAMPVFSKQNETRSKGILLGVVGTDVPVKELLKTIPKY KLGIHGYAFAITNNGYILTHPELRLLYEEGKKRRKPNYSSVDLSEVEWEDRDDVLRNAMVNRKTGKFSMEVKKTVDKGKRVLVMTNDYYY TDIKGTPFSLGVALSRGHGKYFFRGNVTIEEGLHDLEHPDVSLADEWSYCNTDLHPEHRHLSQLEAIKLYLKGKEPLLQCDKELIQEVLF DAVVSAPIEAYWTSLALNKSENSDKGVEVAFLGTRTGLSRINLFVGAEQLTNQDFLKAGDKENIFNADHFPLWYRRAAEQIPGSFVYSIP FSTGPVNKSNVVTASTSIQLLDERKSPVVAAVGIQMKLEFFQRKFWTASRQCASLDGKCSISCDDETVNCYLIDNNGFILVSEDYTQTGD FFGEIEGAVMNKLLTMGSFKRITLYDYQAMCRANKESSDGAHGLLDPYNAFLSAVKWIMTELVLFLVEFNLCSWWHSDMTAKAQKLKQTL EPCDTEYPAFVSERTIKETTGNIACEDCSKSFVIQQIPSSNLFMVVVDSSCLCESVAPITMAPIEIRYNESLKCERLKAQKIRRRPESCH -------------------------------------------------------------- >68675_68675_9_PRKAR2A-CACNA2D3_PRKAR2A_chr3_48884768_ENST00000454963_CACNA2D3_chr3_54537519_ENST00000288197_length(amino acids)=1025AA_BP=61 MTSSNSQWSTSPACARPAPQPQSCPPPPHARAWATPRQNPARTVSPTPKGTASRRRTRTWKYEYFNAVLINERDKDGNFLELGKEFILAP NDHFNNLPVNISLSDVQVPTNMYNKDPAIVNGVYWSESLNKVFVDNFDRDPSLIWQYFGSAKGFFRQYPGIKWEPDENGVIAFDCRNRKW YIQAATSPKDVVILVDVSGSMKGLRLTIAKQTVSSILDTLGDDDFFNIIAYNEELHYVEPCLNGTLVQADRTNKEHFREHLDKLFAKGIG MLDIALNEAFNILSDFNHTGQGSICSQAIMLITDGAVDTYDTIFAKYNWPDRKVRIFTYLIGREAAFADNLKWMACANKGFFTQISTLAD VQENVMEYLHVLSRPKVIDQEHDVVWTEAYIDSTLPQAQKLTDDQGPVLMTTVAMPVFSKQNETRSKGILLGVVGTDVPVKELLKTIPKY KLGIHGYAFAITNNGYILTHPELRLLYEEGKKRRKPNYSSVDLSEVEWEDRDDVLRNAMVNRKTGKFSMEVKKTVDKGKRVLVMTNDYYY TDIKGTPFSLGVALSRGHGKYFFRGNVTIEEGLHDLEHPDVSLADEWSYCNTDLHPEHRHLSQLEAIKLYLKGKEPLLQCDKELIQEVLF DAVVSAPIEAYWTSLALNKSENSDKGVEVAFLGTRTGLSRINLFVGAEQLTNQDFLKAGDKENIFNADHFPLWYRRAAEQIPGSFVYSIP FSTGPVNKSNVVTASTSIQLLDERKSPVVAAVGIQMKLEFFQRKFWTASRQCASLDGKCSISCDDETVNCYLIDNNGFILVSEDYTQTGD FFGEIEGAVMNKLLTMGSFKRITLYDYQAMCRANKESSDGAHGLLDPYNAFLSAVKWIMTELVLFLVEFNLCSWWHSDMTAKAQKLKQTL EPCDTEYPAFVSERTIKETTGNIACEDCSKSFVIQQIPSSNLFMVVVDSSCLCESVAPITMAPIEIRYNESLKCERLKAQKIRRRPESCH -------------------------------------------------------------- >68675_68675_10_PRKAR2A-CACNA2D3_PRKAR2A_chr3_48884768_ENST00000454963_CACNA2D3_chr3_54537519_ENST00000415676_length(amino acids)=1025AA_BP=61 MTSSNSQWSTSPACARPAPQPQSCPPPPHARAWATPRQNPARTVSPTPKGTASRRRTRTWKYEYFNAVLINERDKDGNFLELGKEFILAP NDHFNNLPVNISLSDVQVPTNMYNKDPAIVNGVYWSESLNKVFVDNFDRDPSLIWQYFGSAKGFFRQYPGIKWEPDENGVIAFDCRNRKW YIQAATSPKDVVILVDVSGSMKGLRLTIAKQTVSSILDTLGDDDFFNIIAYNEELHYVEPCLNGTLVQADRTNKEHFREHLDKLFAKGIG MLDIALNEAFNILSDFNHTGQGSICSQAIMLITDGAVDTYDTIFAKYNWPDRKVRIFTYLIGREAAFADNLKWMACANKGFFTQISTLAD VQENVMEYLHVLSRPKVIDQEHDVVWTEAYIDSTLPQAQKLTDDQGPVLMTTVAMPVFSKQNETRSKGILLGVVGTDVPVKELLKTIPKY KLGIHGYAFAITNNGYILTHPELRLLYEEGKKRRKPNYSSVDLSEVEWEDRDDVLRNAMVNRKTGKFSMEVKKTVDKGKRVLVMTNDYYY TDIKGTPFSLGVALSRGHGKYFFRGNVTIEEGLHDLEHPDVSLADEWSYCNTDLHPEHRHLSQLEAIKLYLKGKEPLLQCDKELIQEVLF DAVVSAPIEAYWTSLALNKSENSDKGVEVAFLGTRTGLSRINLFVGAEQLTNQDFLKAGDKENIFNADHFPLWYRRAAEQIPGSFVYSIP FSTGPVNKSNVVTASTSIQLLDERKSPVVAAVGIQMKLEFFQRKFWTASRQCASLDGKCSISCDDETVNCYLIDNNGFILVSEDYTQTGD FFGEIEGAVMNKLLTMGSFKRITLYDYQAMCRANKESSDGAHGLLDPYNAFLSAVKWIMTELVLFLVEFNLCSWWHSDMTAKAQKLKQTL EPCDTEYPAFVSERTIKETTGNIACEDCSKSFVIQQIPSSNLFMVVVDSSCLCESVAPITMAPIEIRYNESLKCERLKAQKIRRRPESCH -------------------------------------------------------------- >68675_68675_11_PRKAR2A-CACNA2D3_PRKAR2A_chr3_48884768_ENST00000454963_CACNA2D3_chr3_54537519_ENST00000474759_length(amino acids)=1025AA_BP=61 MTSSNSQWSTSPACARPAPQPQSCPPPPHARAWATPRQNPARTVSPTPKGTASRRRTRTWKYEYFNAVLINERDKDGNFLELGKEFILAP NDHFNNLPVNISLSDVQVPTNMYNKDPAIVNGVYWSESLNKVFVDNFDRDPSLIWQYFGSAKGFFRQYPGIKWEPDENGVIAFDCRNRKW YIQAATSPKDVVILVDVSGSMKGLRLTIAKQTVSSILDTLGDDDFFNIIAYNEELHYVEPCLNGTLVQADRTNKEHFREHLDKLFAKGIG MLDIALNEAFNILSDFNHTGQGSICSQAIMLITDGAVDTYDTIFAKYNWPDRKVRIFTYLIGREAAFADNLKWMACANKGFFTQISTLAD VQENVMEYLHVLSRPKVIDQEHDVVWTEAYIDSTLPQAQKLTDDQGPVLMTTVAMPVFSKQNETRSKGILLGVVGTDVPVKELLKTIPKY KLGIHGYAFAITNNGYILTHPELRLLYEEGKKRRKPNYSSVDLSEVEWEDRDDVLRNAMVNRKTGKFSMEVKKTVDKGKRVLVMTNDYYY TDIKGTPFSLGVALSRGHGKYFFRGNVTIEEGLHDLEHPDVSLADEWSYCNTDLHPEHRHLSQLEAIKLYLKGKEPLLQCDKELIQEVLF DAVVSAPIEAYWTSLALNKSENSDKGVEVAFLGTRTGLSRINLFVGAEQLTNQDFLKAGDKENIFNADHFPLWYRRAAEQIPGSFVYSIP FSTGPVNKSNVVTASTSIQLLDERKSPVVAAVGIQMKLEFFQRKFWTASRQCASLDGKCSISCDDETVNCYLIDNNGFILVSEDYTQTGD FFGEIEGAVMNKLLTMGSFKRITLYDYQAMCRANKESSDGAHGLLDPYNAFLSAVKWIMTELVLFLVEFNLCSWWHSDMTAKAQKLKQTL EPCDTEYPAFVSERTIKETTGNIACEDCSKSFVIQQIPSSNLFMVVVDSSCLCESVAPITMAPIEIRYNESLKCERLKAQKIRRRPESCH -------------------------------------------------------------- >68675_68675_12_PRKAR2A-CACNA2D3_PRKAR2A_chr3_48884768_ENST00000454963_CACNA2D3_chr3_54537519_ENST00000490478_length(amino acids)=1025AA_BP=61 MTSSNSQWSTSPACARPAPQPQSCPPPPHARAWATPRQNPARTVSPTPKGTASRRRTRTWKYEYFNAVLINERDKDGNFLELGKEFILAP NDHFNNLPVNISLSDVQVPTNMYNKDPAIVNGVYWSESLNKVFVDNFDRDPSLIWQYFGSAKGFFRQYPGIKWEPDENGVIAFDCRNRKW YIQAATSPKDVVILVDVSGSMKGLRLTIAKQTVSSILDTLGDDDFFNIIAYNEELHYVEPCLNGTLVQADRTNKEHFREHLDKLFAKGIG MLDIALNEAFNILSDFNHTGQGSICSQAIMLITDGAVDTYDTIFAKYNWPDRKVRIFTYLIGREAAFADNLKWMACANKGFFTQISTLAD VQENVMEYLHVLSRPKVIDQEHDVVWTEAYIDSTLPQAQKLTDDQGPVLMTTVAMPVFSKQNETRSKGILLGVVGTDVPVKELLKTIPKY KLGIHGYAFAITNNGYILTHPELRLLYEEGKKRRKPNYSSVDLSEVEWEDRDDVLRNAMVNRKTGKFSMEVKKTVDKGKRVLVMTNDYYY TDIKGTPFSLGVALSRGHGKYFFRGNVTIEEGLHDLEHPDVSLADEWSYCNTDLHPEHRHLSQLEAIKLYLKGKEPLLQCDKELIQEVLF DAVVSAPIEAYWTSLALNKSENSDKGVEVAFLGTRTGLSRINLFVGAEQLTNQDFLKAGDKENIFNADHFPLWYRRAAEQIPGSFVYSIP FSTGPVNKSNVVTASTSIQLLDERKSPVVAAVGIQMKLEFFQRKFWTASRQCASLDGKCSISCDDETVNCYLIDNNGFILVSEDYTQTGD FFGEIEGAVMNKLLTMGSFKRITLYDYQAMCRANKESSDGAHGLLDPYNAFLSAVKWIMTELVLFLVEFNLCSWWHSDMTAKAQKLKQTL EPCDTEYPAFVSERTIKETTGNIACEDCSKSFVIQQIPSSNLFMVVVDSSCLCESVAPITMAPIEIRYNESLKCERLKAQKIRRRPESCH -------------------------------------------------------------- |
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Fusion Protein Functional Features |
![]() Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr3:48884768/chr3:54537519) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
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Hgene | Tgene |
PRKAR2A | CACNA2D3 |
FUNCTION: Regulatory subunit of the cAMP-dependent protein kinases involved in cAMP signaling in cells. Type II regulatory chains mediate membrane association by binding to anchoring proteins, including the MAP2 kinase. | FUNCTION: The alpha-2/delta subunit of voltage-dependent calcium channels regulates calcium current density and activation/inactivation kinetics of the calcium channel. Acts as a regulatory subunit for P/Q-type calcium channel (CACNA1A), N-type (CACNA1B), L-type (CACNA1C OR CACNA1D) but not T-type (CACNA1G) (By similarity). {ECO:0000250}. |
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- Retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Tgene | CACNA2D3 | chr3:48884768 | chr3:54537519 | ENST00000288197 | 3 | 38 | 256_438 | 127.0 | 1092.0 | Domain | VWFA | |
Tgene | CACNA2D3 | chr3:48884768 | chr3:54537519 | ENST00000288197 | 3 | 38 | 452_549 | 127.0 | 1092.0 | Domain | Note=Cache | |
Tgene | CACNA2D3 | chr3:48884768 | chr3:54537519 | ENST00000415676 | 4 | 39 | 256_438 | 127.0 | 1092.0 | Domain | VWFA | |
Tgene | CACNA2D3 | chr3:48884768 | chr3:54537519 | ENST00000415676 | 4 | 39 | 452_549 | 127.0 | 1092.0 | Domain | Note=Cache | |
Tgene | CACNA2D3 | chr3:48884768 | chr3:54537519 | ENST00000474759 | 3 | 38 | 256_438 | 127.0 | 1092.0 | Domain | VWFA | |
Tgene | CACNA2D3 | chr3:48884768 | chr3:54537519 | ENST00000474759 | 3 | 38 | 452_549 | 127.0 | 1092.0 | Domain | Note=Cache | |
Tgene | CACNA2D3 | chr3:48884768 | chr3:54537519 | ENST00000490478 | 2 | 37 | 256_438 | 33.0 | 998.0 | Domain | VWFA | |
Tgene | CACNA2D3 | chr3:48884768 | chr3:54537519 | ENST00000490478 | 2 | 37 | 452_549 | 33.0 | 998.0 | Domain | Note=Cache | |
Tgene | CACNA2D3 | chr3:48884768 | chr3:54537519 | ENST00000288197 | 3 | 38 | 262_266 | 127.0 | 1092.0 | Motif | Note=MIDAS-like motif | |
Tgene | CACNA2D3 | chr3:48884768 | chr3:54537519 | ENST00000415676 | 4 | 39 | 262_266 | 127.0 | 1092.0 | Motif | Note=MIDAS-like motif | |
Tgene | CACNA2D3 | chr3:48884768 | chr3:54537519 | ENST00000474759 | 3 | 38 | 262_266 | 127.0 | 1092.0 | Motif | Note=MIDAS-like motif | |
Tgene | CACNA2D3 | chr3:48884768 | chr3:54537519 | ENST00000490478 | 2 | 37 | 262_266 | 33.0 | 998.0 | Motif | Note=MIDAS-like motif | |
Tgene | CACNA2D3 | chr3:48884768 | chr3:54537519 | ENST00000288197 | 3 | 38 | 1090_1091 | 127.0 | 1092.0 | Topological domain | Cytoplasmic | |
Tgene | CACNA2D3 | chr3:48884768 | chr3:54537519 | ENST00000415676 | 4 | 39 | 1090_1091 | 127.0 | 1092.0 | Topological domain | Cytoplasmic | |
Tgene | CACNA2D3 | chr3:48884768 | chr3:54537519 | ENST00000474759 | 3 | 38 | 1090_1091 | 127.0 | 1092.0 | Topological domain | Cytoplasmic | |
Tgene | CACNA2D3 | chr3:48884768 | chr3:54537519 | ENST00000490478 | 2 | 37 | 1090_1091 | 33.0 | 998.0 | Topological domain | Cytoplasmic | |
Tgene | CACNA2D3 | chr3:48884768 | chr3:54537519 | ENST00000288197 | 3 | 38 | 1069_1089 | 127.0 | 1092.0 | Transmembrane | Helical | |
Tgene | CACNA2D3 | chr3:48884768 | chr3:54537519 | ENST00000415676 | 4 | 39 | 1069_1089 | 127.0 | 1092.0 | Transmembrane | Helical | |
Tgene | CACNA2D3 | chr3:48884768 | chr3:54537519 | ENST00000474759 | 3 | 38 | 1069_1089 | 127.0 | 1092.0 | Transmembrane | Helical | |
Tgene | CACNA2D3 | chr3:48884768 | chr3:54537519 | ENST00000490478 | 2 | 37 | 1069_1089 | 33.0 | 998.0 | Transmembrane | Helical |
- Not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Hgene | PRKAR2A | chr3:48884768 | chr3:54537519 | ENST00000265563 | - | 1 | 11 | 139_260 | 87.33333333333333 | 405.0 | Nucleotide binding | Note=cAMP 1 |
Hgene | PRKAR2A | chr3:48884768 | chr3:54537519 | ENST00000265563 | - | 1 | 11 | 261_404 | 87.33333333333333 | 405.0 | Nucleotide binding | Note=cAMP 2 |
Hgene | PRKAR2A | chr3:48884768 | chr3:54537519 | ENST00000454963 | - | 1 | 12 | 139_260 | 87.33333333333333 | 423.0 | Nucleotide binding | Note=cAMP 1 |
Hgene | PRKAR2A | chr3:48884768 | chr3:54537519 | ENST00000454963 | - | 1 | 12 | 261_404 | 87.33333333333333 | 423.0 | Nucleotide binding | Note=cAMP 2 |
Hgene | PRKAR2A | chr3:48884768 | chr3:54537519 | ENST00000265563 | - | 1 | 11 | 2_138 | 87.33333333333333 | 405.0 | Region | Note=Dimerization and phosphorylation |
Hgene | PRKAR2A | chr3:48884768 | chr3:54537519 | ENST00000454963 | - | 1 | 12 | 2_138 | 87.33333333333333 | 423.0 | Region | Note=Dimerization and phosphorylation |
Tgene | CACNA2D3 | chr3:48884768 | chr3:54537519 | ENST00000288197 | 3 | 38 | 29_1068 | 127.0 | 1092.0 | Topological domain | Extracellular | |
Tgene | CACNA2D3 | chr3:48884768 | chr3:54537519 | ENST00000415676 | 4 | 39 | 29_1068 | 127.0 | 1092.0 | Topological domain | Extracellular | |
Tgene | CACNA2D3 | chr3:48884768 | chr3:54537519 | ENST00000474759 | 3 | 38 | 29_1068 | 127.0 | 1092.0 | Topological domain | Extracellular | |
Tgene | CACNA2D3 | chr3:48884768 | chr3:54537519 | ENST00000490478 | 2 | 37 | 29_1068 | 33.0 | 998.0 | Topological domain | Extracellular |
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Fusion Protein Structures |
![]() * Here we show the 3D structure of the fusion proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format. |
Fusion protein PDB link (fusion AA seq ID in FusionPDB) | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | AA seq | Len(AA seq) |
PDB file >>>1805_PRKAR2A_48884768_CACNA2D3_54537519_ranked_0.pdb | PRKAR2A | 48884768 | 48884768 | ENST00000490478 | CACNA2D3 | chr3 | 54537519 | + | MTSSNSQWSTSPACARPAPQPQSCPPPPHARAWATPRQNPARTVSPTPKGTASRRRTRTWKYEYFNAVLINERDKDGNFLELGKEFILAP NDHFNNLPVNISLSDVQVPTNMYNKDPAIVNGVYWSESLNKVFVDNFDRDPSLIWQYFGSAKGFFRQYPGIKWEPDENGVIAFDCRNRKW YIQAATSPKDVVILVDVSGSMKGLRLTIAKQTVSSILDTLGDDDFFNIIAYNEELHYVEPCLNGTLVQADRTNKEHFREHLDKLFAKGIG MLDIALNEAFNILSDFNHTGQGSICSQAIMLITDGAVDTYDTIFAKYNWPDRKVRIFTYLIGREAAFADNLKWMACANKGFFTQISTLAD VQENVMEYLHVLSRPKVIDQEHDVVWTEAYIDSTLPQAQKLTDDQGPVLMTTVAMPVFSKQNETRSKGILLGVVGTDVPVKELLKTIPKY KLGIHGYAFAITNNGYILTHPELRLLYEEGKKRRKPNYSSVDLSEVEWEDRDDVLRNAMVNRKTGKFSMEVKKTVDKGKRVLVMTNDYYY TDIKGTPFSLGVALSRGHGKYFFRGNVTIEEGLHDLEHPDVSLADEWSYCNTDLHPEHRHLSQLEAIKLYLKGKEPLLQCDKELIQEVLF DAVVSAPIEAYWTSLALNKSENSDKGVEVAFLGTRTGLSRINLFVGAEQLTNQDFLKAGDKENIFNADHFPLWYRRAAEQIPGSFVYSIP FSTGPVNKSNVVTASTSIQLLDERKSPVVAAVGIQMKLEFFQRKFWTASRQCASLDGKCSISCDDETVNCYLIDNNGFILVSEDYTQTGD FFGEIEGAVMNKLLTMGSFKRITLYDYQAMCRANKESSDGAHGLLDPYNAFLSAVKWIMTELVLFLVEFNLCSWWHSDMTAKAQKLKQTL EPCDTEYPAFVSERTIKETTGNIACEDCSKSFVIQQIPSSNLFMVVVDSSCLCESVAPITMAPIEIRYNESLKCERLKAQKIRRRPESCH | 1025 |
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pLDDT score distribution |
![]() * AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. |
PRKAR2A_pLDDT.png![]() |
CACNA2D3_pLDDT.png![]() |
![]() * AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. |
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Ramachandran Plot of Fusion Protein Structure |
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Fusion AA seq ID in FusionPDB and their Ramachandran plots |
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Fusion Protein-Protein Interaction |
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Gene | PPI interactors |
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Gene | STRING network |
PRKAR2A | ![]() |
CACNA2D3 |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs to PRKAR2A-CACNA2D3 |
![]() (Manual curation of PubMed, 04-30-2022 + MyCancerGenome) |
Hgene | Tgene | Drug | Source | PMID |
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Related Diseases to PRKAR2A-CACNA2D3 |
![]() (Manual curation of PubMed, 04-30-2022 + MyCancerGenome) |
Hgene | Tgene | Disease | Source | PMID |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |