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	Fusion Gene Summary
	Fusion Gene Sample Information
	Fusion ORF Analysis
	Fusion Amino Acid Sequences
	Fusion Protein Functional Features
	Fusion Protein-Protein Interaction
	Related drugs with this fusion protein
	Related disease with this fusion protein

Fusion Protein:PRKCB-RPS2

Fusion Protein Summary

Fusion gene summary

Fusion partner gene information	Fusion gene name: PRKCB-RPS2
	FusionPDB ID: 68738
	FusionGDB2.0 ID: 68738
		Hgene	Tgene
	Gene symbol	PRKCB	RPS2
	Gene ID	5579	6187
	Gene name	protein kinase C beta	ribosomal protein S2
	Synonyms	PKC-beta\|PKCB\|PKCI(2)\|PKCbeta\|PRKCB1\|PRKCB2	LLREP3\|S2
	Cytomap	16p12.2-p12.1	16p13.3
	Type of gene	protein-coding	protein-coding
	Description	protein kinase C beta typePKC-Bprotein kinase C, beta 1 polypeptide	40S ribosomal protein S240S ribosomal protein S4OK/KNS-cl.6protein LLRep3small ribosomal subunit protein uS5
	Modification date	20200313	20200313
	UniProtAcc	.	.
Ensembl transtripts involved in fusion gene	ENST ids	ENST00000303531, ENST00000321728, ENST00000482000, ENST00000498058,	ENST00000343262, ENST00000526522, ENST00000529806, ENST00000530225,
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)	* DoF score	8 X 8 X 3=192	10 X 8 X 4=320
	# samples	8	11
	** MAII score	log2(8/192*10)=-1.26303440583379 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(11/320*10)=-1.5405683813627 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)	PubMed: PRKCB [Title/Abstract] AND RPS2 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)	PRKCB(24135302)-RPS2(2013257), # samples:1
Anticipated loss of major functional domain due to fusion event.	PRKCB-RPS2 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. PRKCB-RPS2 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. PRKCB-RPS2 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. PRKCB-RPS2 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	PRKCB	GO:0010827	regulation of glucose transmembrane transport	25982116
Hgene	PRKCB	GO:0035408	histone H3-T6 phosphorylation	20228790
Tgene	RPS2	GO:0051443	positive regulation of ubiquitin-protein transferase activity	18573314

Fusion gene breakpoints across PRKCB (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across RPS2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

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Fusion Gene Sample Information

Fusion gene information from FusionGDB2.0.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	PRAD	TCGA-KK-A8I7	PRKCB	chr16	24135302	+	RPS2	chr16	2013257	-

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Fusion ORF Analysis

Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000321728	PRKCB	chr16	24135302	+	ENST00000343262	RPS2	chr16	2013257	-	1901	1240	175	1854	559
ENST00000321728	PRKCB	chr16	24135302	+	ENST00000526522	RPS2	chr16	2013257	-	1719	1240	175	1680	501
ENST00000321728	PRKCB	chr16	24135302	+	ENST00000530225	RPS2	chr16	2013257	-	1732	1240	175	1566	463
ENST00000321728	PRKCB	chr16	24135302	+	ENST00000529806	RPS2	chr16	2013257	-	1869	1240	175	1692	505
ENST00000303531	PRKCB	chr16	24135302	+	ENST00000343262	RPS2	chr16	2013257	-	1878	1217	152	1831	559
ENST00000303531	PRKCB	chr16	24135302	+	ENST00000526522	RPS2	chr16	2013257	-	1696	1217	152	1657	501
ENST00000303531	PRKCB	chr16	24135302	+	ENST00000530225	RPS2	chr16	2013257	-	1709	1217	152	1543	463
ENST00000303531	PRKCB	chr16	24135302	+	ENST00000529806	RPS2	chr16	2013257	-	1846	1217	152	1669	505

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000321728	ENST00000343262	PRKCB	chr16	24135302	+	RPS2	chr16	2013257	-	0.008438426	0.9915616
ENST00000321728	ENST00000526522	PRKCB	chr16	24135302	+	RPS2	chr16	2013257	-	0.008434656	0.99156535
ENST00000321728	ENST00000530225	PRKCB	chr16	24135302	+	RPS2	chr16	2013257	-	0.005872683	0.9941273
ENST00000321728	ENST00000529806	PRKCB	chr16	24135302	+	RPS2	chr16	2013257	-	0.00758353	0.9924165
ENST00000303531	ENST00000343262	PRKCB	chr16	24135302	+	RPS2	chr16	2013257	-	0.008444286	0.99155575
ENST00000303531	ENST00000526522	PRKCB	chr16	24135302	+	RPS2	chr16	2013257	-	0.008251431	0.9917486
ENST00000303531	ENST00000530225	PRKCB	chr16	24135302	+	RPS2	chr16	2013257	-	0.005703495	0.9942965
ENST00000303531	ENST00000529806	PRKCB	chr16	24135302	+	RPS2	chr16	2013257	-	0.007457883	0.99254215

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Fusion Amino Acid Sequences

For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>68738_68738_1_PRKCB-RPS2_PRKCB_chr16_24135302_ENST00000303531_RPS2_chr16_2013257_ENST00000343262_length(amino acids)=559AA_BP=355
MADPAAGPPPSEGEESTVRFARKGALRQKNVHEVKNHKFTARFFKQPTFCSHCTDFIWGFGKQGFQCQVCCFVVHKRCHEFVTFSCPGAD
KGPASDDPRSKHKFKIHTYSSPTFCDHCGSLLYGLIHQGMKCDTCMMNVHKRCVMNVPSLCGTDHTERRGRIYIQAHIDRDVLIVLVRDA
KNLVPMDPNGLSDPYVKLKLIPDPKSESKQKTKTIKCSLNPEWNETFRFQLKESDKDRRLSVEIWDWDLTSRNDFMGSLSFGISELQKAS
VDGWFKLLSQEEGEYFNVPVPPEGSEANEELRQKFERAKISQGTKVPEEKTTNTVSKFDNNGNRDRMKLTDFNFLMVLGKGSFGKESEII
DFFLGASLKDEVLKIMPVQKQTRAGQRTRFKAFVAIGDYNGHVGLGVKCSKEVATAIRGAIILAKLSIVPVRRGYWGNKIGKPHTVPCKV
TGRCGSVLVRLIPAPRGTGIVSAPVPKKLLMMAGIDDCYTSARGCTATLGNFAKATFDAISKTYSYLTPDLWKETVFTKSPYQEFTDHLV

--------------------------------------------------------------

>68738_68738_2_PRKCB-RPS2_PRKCB_chr16_24135302_ENST00000303531_RPS2_chr16_2013257_ENST00000526522_length(amino acids)=501AA_BP=355
MADPAAGPPPSEGEESTVRFARKGALRQKNVHEVKNHKFTARFFKQPTFCSHCTDFIWGFGKQGFQCQVCCFVVHKRCHEFVTFSCPGAD
KGPASDDPRSKHKFKIHTYSSPTFCDHCGSLLYGLIHQGMKCDTCMMNVHKRCVMNVPSLCGTDHTERRGRIYIQAHIDRDVLIVLVRDA
KNLVPMDPNGLSDPYVKLKLIPDPKSESKQKTKTIKCSLNPEWNETFRFQLKESDKDRRLSVEIWDWDLTSRNDFMGSLSFGISELQKAS
VDGWFKLLSQEEGEYFNVPVPPEGSEANEELRQKFERAKISQGTKVPEEKTTNTVSKFDNNGNRDRMKLTDFNFLMVLGKGSFGKESEII
DFFLGASLKDEVLKIMPVQKQTRAGQRTRFKVTGRCGSVLVRLIPAPRGTGIVSAPVPKKLLMMAGIDDCYTSARGCTATLGNFAKATFD

--------------------------------------------------------------

>68738_68738_3_PRKCB-RPS2_PRKCB_chr16_24135302_ENST00000303531_RPS2_chr16_2013257_ENST00000529806_length(amino acids)=505AA_BP=355
MADPAAGPPPSEGEESTVRFARKGALRQKNVHEVKNHKFTARFFKQPTFCSHCTDFIWGFGKQGFQCQVCCFVVHKRCHEFVTFSCPGAD
KGPASDDPRSKHKFKIHTYSSPTFCDHCGSLLYGLIHQGMKCDTCMMNVHKRCVMNVPSLCGTDHTERRGRIYIQAHIDRDVLIVLVRDA
KNLVPMDPNGLSDPYVKLKLIPDPKSESKQKTKTIKCSLNPEWNETFRFQLKESDKDRRLSVEIWDWDLTSRNDFMGSLSFGISELQKAS
VDGWFKLLSQEEGEYFNVPVPPEGSEANEELRQKFERAKISQGTKVPEEKTTNTVSKFDNNGNRDRMKLTDFNFLMVLGKGSFGKESEII
DFFLGASLKDEVLKIMPVQKQTRAGQRTRFKAFVAIGDYNGHVGLGVKCSKEVATAIRGAIILAKLSIVPVRRGYWGNKIGKPHTVPCKV

--------------------------------------------------------------

>68738_68738_4_PRKCB-RPS2_PRKCB_chr16_24135302_ENST00000303531_RPS2_chr16_2013257_ENST00000530225_length(amino acids)=463AA_BP=355
MADPAAGPPPSEGEESTVRFARKGALRQKNVHEVKNHKFTARFFKQPTFCSHCTDFIWGFGKQGFQCQVCCFVVHKRCHEFVTFSCPGAD
KGPASDDPRSKHKFKIHTYSSPTFCDHCGSLLYGLIHQGMKCDTCMMNVHKRCVMNVPSLCGTDHTERRGRIYIQAHIDRDVLIVLVRDA
KNLVPMDPNGLSDPYVKLKLIPDPKSESKQKTKTIKCSLNPEWNETFRFQLKESDKDRRLSVEIWDWDLTSRNDFMGSLSFGISELQKAS
VDGWFKLLSQEEGEYFNVPVPPEGSEANEELRQKFERAKISQGTKVPEEKTTNTVSKFDNNGNRDRMKLTDFNFLMVLGKGSFGKESEII
DFFLGASLKDEVLKIMPVQKQTRAGQRTRFKAFVAIGDYNGHVGLGVKCSKEVATAIRGAIILAKLSIVPVRRGYWGNKIGKPHTVPCKP

--------------------------------------------------------------

>68738_68738_5_PRKCB-RPS2_PRKCB_chr16_24135302_ENST00000321728_RPS2_chr16_2013257_ENST00000343262_length(amino acids)=559AA_BP=355
MADPAAGPPPSEGEESTVRFARKGALRQKNVHEVKNHKFTARFFKQPTFCSHCTDFIWGFGKQGFQCQVCCFVVHKRCHEFVTFSCPGAD
KGPASDDPRSKHKFKIHTYSSPTFCDHCGSLLYGLIHQGMKCDTCMMNVHKRCVMNVPSLCGTDHTERRGRIYIQAHIDRDVLIVLVRDA
KNLVPMDPNGLSDPYVKLKLIPDPKSESKQKTKTIKCSLNPEWNETFRFQLKESDKDRRLSVEIWDWDLTSRNDFMGSLSFGISELQKAS
VDGWFKLLSQEEGEYFNVPVPPEGSEANEELRQKFERAKISQGTKVPEEKTTNTVSKFDNNGNRDRMKLTDFNFLMVLGKGSFGKESEII
DFFLGASLKDEVLKIMPVQKQTRAGQRTRFKAFVAIGDYNGHVGLGVKCSKEVATAIRGAIILAKLSIVPVRRGYWGNKIGKPHTVPCKV
TGRCGSVLVRLIPAPRGTGIVSAPVPKKLLMMAGIDDCYTSARGCTATLGNFAKATFDAISKTYSYLTPDLWKETVFTKSPYQEFTDHLV

--------------------------------------------------------------

>68738_68738_6_PRKCB-RPS2_PRKCB_chr16_24135302_ENST00000321728_RPS2_chr16_2013257_ENST00000526522_length(amino acids)=501AA_BP=355
MADPAAGPPPSEGEESTVRFARKGALRQKNVHEVKNHKFTARFFKQPTFCSHCTDFIWGFGKQGFQCQVCCFVVHKRCHEFVTFSCPGAD
KGPASDDPRSKHKFKIHTYSSPTFCDHCGSLLYGLIHQGMKCDTCMMNVHKRCVMNVPSLCGTDHTERRGRIYIQAHIDRDVLIVLVRDA
KNLVPMDPNGLSDPYVKLKLIPDPKSESKQKTKTIKCSLNPEWNETFRFQLKESDKDRRLSVEIWDWDLTSRNDFMGSLSFGISELQKAS
VDGWFKLLSQEEGEYFNVPVPPEGSEANEELRQKFERAKISQGTKVPEEKTTNTVSKFDNNGNRDRMKLTDFNFLMVLGKGSFGKESEII
DFFLGASLKDEVLKIMPVQKQTRAGQRTRFKVTGRCGSVLVRLIPAPRGTGIVSAPVPKKLLMMAGIDDCYTSARGCTATLGNFAKATFD

--------------------------------------------------------------

>68738_68738_7_PRKCB-RPS2_PRKCB_chr16_24135302_ENST00000321728_RPS2_chr16_2013257_ENST00000529806_length(amino acids)=505AA_BP=355
MADPAAGPPPSEGEESTVRFARKGALRQKNVHEVKNHKFTARFFKQPTFCSHCTDFIWGFGKQGFQCQVCCFVVHKRCHEFVTFSCPGAD
KGPASDDPRSKHKFKIHTYSSPTFCDHCGSLLYGLIHQGMKCDTCMMNVHKRCVMNVPSLCGTDHTERRGRIYIQAHIDRDVLIVLVRDA
KNLVPMDPNGLSDPYVKLKLIPDPKSESKQKTKTIKCSLNPEWNETFRFQLKESDKDRRLSVEIWDWDLTSRNDFMGSLSFGISELQKAS
VDGWFKLLSQEEGEYFNVPVPPEGSEANEELRQKFERAKISQGTKVPEEKTTNTVSKFDNNGNRDRMKLTDFNFLMVLGKGSFGKESEII
DFFLGASLKDEVLKIMPVQKQTRAGQRTRFKAFVAIGDYNGHVGLGVKCSKEVATAIRGAIILAKLSIVPVRRGYWGNKIGKPHTVPCKV

--------------------------------------------------------------

>68738_68738_8_PRKCB-RPS2_PRKCB_chr16_24135302_ENST00000321728_RPS2_chr16_2013257_ENST00000530225_length(amino acids)=463AA_BP=355
MADPAAGPPPSEGEESTVRFARKGALRQKNVHEVKNHKFTARFFKQPTFCSHCTDFIWGFGKQGFQCQVCCFVVHKRCHEFVTFSCPGAD
KGPASDDPRSKHKFKIHTYSSPTFCDHCGSLLYGLIHQGMKCDTCMMNVHKRCVMNVPSLCGTDHTERRGRIYIQAHIDRDVLIVLVRDA
KNLVPMDPNGLSDPYVKLKLIPDPKSESKQKTKTIKCSLNPEWNETFRFQLKESDKDRRLSVEIWDWDLTSRNDFMGSLSFGISELQKAS
VDGWFKLLSQEEGEYFNVPVPPEGSEANEELRQKFERAKISQGTKVPEEKTTNTVSKFDNNGNRDRMKLTDFNFLMVLGKGSFGKESEII
DFFLGASLKDEVLKIMPVQKQTRAGQRTRFKAFVAIGDYNGHVGLGVKCSKEVATAIRGAIILAKLSIVPVRRGYWGNKIGKPHTVPCKP

--------------------------------------------------------------

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Fusion Protein Functional Features

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr16:24135302/chr16:2013257)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	.
FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.	FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
* Minus value of BPloci means that the break pointn is located before the CDS.

- Retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

PRKCB

chr16:24135302

chr16:2013257

ENST00000303531

158_275

355.0

674.0

Domain

Hgene

PRKCB

chr16:24135302

chr16:2013257

ENST00000321728

158_275

355.0

672.0

Domain

Hgene

PRKCB

chr16:24135302

chr16:2013257

ENST00000303531

348_356

355.0

674.0

Nucleotide binding

ATP

Hgene

PRKCB

chr16:24135302

chr16:2013257

ENST00000321728

348_356

355.0

672.0

Nucleotide binding

ATP

Hgene

PRKCB

chr16:24135302

chr16:2013257

ENST00000303531

101_151

355.0

674.0

Zinc finger

Phorbol-ester/DAG-type 2

Hgene

PRKCB

chr16:24135302

chr16:2013257

ENST00000303531

36_86

355.0

674.0

Zinc finger

Phorbol-ester/DAG-type 1

Hgene

PRKCB

chr16:24135302

chr16:2013257

ENST00000321728

101_151

355.0

672.0

Zinc finger

Phorbol-ester/DAG-type 2

Hgene

PRKCB

chr16:24135302

chr16:2013257

ENST00000321728

36_86

355.0

672.0

Zinc finger

Phorbol-ester/DAG-type 1

Tgene

RPS2

chr16:24135302

chr16:2013257

ENST00000343262

102_165

89.0

294.0

Domain

S5 DRBM

- Not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

PRKCB

chr16:24135302

chr16:2013257

ENST00000303531

342_600

355.0

674.0

Domain

Protein kinase

Hgene

PRKCB

chr16:24135302

chr16:2013257

ENST00000303531

601_671

355.0

674.0

Domain

AGC-kinase C-terminal

Hgene

PRKCB

chr16:24135302

chr16:2013257

ENST00000321728

342_600

355.0

672.0

Domain

Protein kinase

Hgene

PRKCB

chr16:24135302

chr16:2013257

ENST00000321728

601_671

355.0

672.0

Domain

AGC-kinase C-terminal

Hgene

PRKCB

chr16:24135302

chr16:2013257

ENST00000498058

158_275

58.0

Domain

Hgene

PRKCB

chr16:24135302

chr16:2013257

ENST00000498058

342_600

58.0

Domain

Protein kinase

Hgene

PRKCB

chr16:24135302

chr16:2013257

ENST00000498058

601_671

58.0

Domain

AGC-kinase C-terminal

Hgene

PRKCB

chr16:24135302

chr16:2013257

ENST00000498058

348_356

58.0

Nucleotide binding

ATP

Hgene

PRKCB

chr16:24135302

chr16:2013257

ENST00000498058

101_151

58.0

Zinc finger

Phorbol-ester/DAG-type 2

Hgene

PRKCB

chr16:24135302

chr16:2013257

ENST00000498058

36_86

58.0

Zinc finger

Phorbol-ester/DAG-type 1

Tgene

RPS2

chr16:24135302

chr16:2013257

ENST00000343262

22_53

89.0

294.0

Compositional bias

Note=Arg/Gly-rich

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Fusion Protein-Protein Interaction

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)

Gene

PPI interactors

Protein-protein interactors based on sequence similarity (STRING)

Gene	STRING network
PRKCB
RPS2

- Retained interactions in fusion protein (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost interactions due to fusion (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs to PRKCB-RPS2

Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Drug

Source

PMID

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Related Diseases to PRKCB-RPS2

Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Disease

Source

PMID

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source