UTHEALTH HOME    ABOUT SBMI    A-Z    WEBMAIL    INSIDE THE UNIVERSITY
FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact

Terms of Use
Center for Computational Systems Medicine level1
leaf

Fusion Gene Summary

leaf

Fusion Gene Sample Information

leaf

Fusion ORF Analysis

leaf

Fusion Amino Acid Sequences

leaf

Fusion Protein Functional Features

leaf

Fusion Protein-Protein Interaction

leaf

Related drugs with this fusion protein

leaf

Related disease with this fusion protein

Fusion Protein:PTPN12-CCDC146

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: PTPN12-CCDC146
FusionPDB ID: 70187
FusionGDB2.0 ID: 70187
HgeneTgene
Gene symbol

PTPN12

CCDC146

Gene ID

5782

57639

Gene nameprotein tyrosine phosphatase non-receptor type 12coiled-coil domain containing 146
SynonymsPTP-PEST|PTPG1MBO2
Cytomap

7q11.23

7q11.23

Type of geneprotein-codingprotein-coding
Descriptiontyrosine-protein phosphatase non-receptor type 12protein-tyrosine phosphatase G1coiled-coil domain-containing protein 146
Modification date2020032920200327
UniProtAcc.

Q8IYE0

Ensembl transtripts involved in fusion geneENST idsENST00000248594, ENST00000415482, 
ENST00000435495, 		ENST00000415740, 
ENST00000285871, ENST00000431197, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score22 X 21 X 16=73925 X 11 X 8=440
# samples 4412
** MAII scorelog2(44/7392*10)=-4.0703893278914
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(12/440*10)=-1.87446911791614
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: PTPN12 [Title/Abstract] AND CCDC146 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)CCDC146(76924255)-PTPN12(77200395), # samples:1
PTPN12(77166962)-CCDC146(76903010), # samples:1
PTPN12(77200503)-CCDC146(76796974), # samples:1
PTPN12(77230123)-CCDC146(76922268), # samples:1
PTPN12(77166962)-CCDC146(76903011), # samples:1
PTPN12(77168162)-CCDC146(76903011), # samples:1
PTPN12(77200503)-CCDC146(76796975), # samples:1
PTPN12(77214898)-CCDC146(76958713), # samples:1
PTPN12(77166962)-CCDC146(76908069), # samples:1
PTPN12(77193512)-CCDC146(76908069), # samples:1
PTPN12(77230123)-CCDC146(76922269), # samples:1
PTPN12(77227218)-CCDC146(76922269), # samples:1
Anticipated loss of major functional domain due to fusion event.PTPN12-CCDC146 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
PTPN12-CCDC146 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
PTPN12-CCDC146 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
PTPN12-CCDC146 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
PTPN12-CCDC146 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
PTPN12-CCDC146 seems lost the major protein functional domain in Hgene partner, which is a tumor suppressor due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgenePTPN12

GO:0006470

protein dephosphorylation

27134172

HgenePTPN12

GO:0035335

peptidyl-tyrosine dephosphorylation

27134172


check buttonFusion gene breakpoints across PTPN12 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across CCDC146 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


Top

Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BLCATCGA-4Z-AA87PTPN12chr7

77166962

+CCDC146chr7

76903010

+
ChimerDB4BLCATCGA-4Z-AA87PTPN12chr7

77166962

+CCDC146chr7

76903011

+
ChimerDB4BLCATCGA-4Z-AA87PTPN12chr7

77168162

+CCDC146chr7

76903011

+
ChimerDB4BRCATCGA-AN-A0FJ-01APTPN12chr7

77200503

+CCDC146chr7

76796975

+
ChimerDB4BRCATCGA-AN-A0FJPTPN12chr7

77200503

+CCDC146chr7

76796974

+
ChimerDB4OVTCGA-3P-A9WA-01APTPN12chr7

77214898

+CCDC146chr7

76958713

+
ChimerDB4SKCMTCGA-ER-A19T-01APTPN12chr7

77166962

+CCDC146chr7

76908069

+
ChimerDB4SKCMTCGA-ER-A19T-01APTPN12chr7

77193512

+CCDC146chr7

76908069

+
ChimerDB4STADTCGA-HU-A4GH-01APTPN12chr7

77227218

+CCDC146chr7

76922269

+
ChimerDB4STADTCGA-HU-A4GH-01APTPN12chr7

77230123

+CCDC146chr7

76922269

+
ChimerDB4STADTCGA-HU-A4GHPTPN12chr7

77230123

+CCDC146chr7

76922268

+


Top

Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000248594PTPN12chr777166962+ENST00000431197CCDC146chr776908069+213737121798598
ENST00000248594PTPN12chr777166962+ENST00000285871CCDC146chr776908069+213737121798598
ENST00000248594PTPN12chr777227218+ENST00000431197CCDC146chr776922269+161582421276424
ENST00000248594PTPN12chr777227218+ENST00000285871CCDC146chr776922269+161582421276424
ENST00000415482PTPN12chr777227218+ENST00000431197CCDC146chr776922269+131652584977297
ENST00000415482PTPN12chr777227218+ENST00000285871CCDC146chr776922269+131652584977297
ENST00000435495PTPN12chr777227218+ENST00000431197CCDC146chr776922269+118639550847265
ENST00000435495PTPN12chr777227218+ENST00000285871CCDC146chr776922269+118639550847265

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000248594ENST00000431197PTPN12chr777166962+CCDC146chr776908069+0.0019389460.998061
ENST00000248594ENST00000285871PTPN12chr777166962+CCDC146chr776908069+0.0019389460.998061
ENST00000248594ENST00000431197PTPN12chr777227218+CCDC146chr776922269+0.000473220.99952674
ENST00000248594ENST00000285871PTPN12chr777227218+CCDC146chr776922269+0.000473220.99952674
ENST00000415482ENST00000431197PTPN12chr777227218+CCDC146chr776922269+0.000817450.9991825
ENST00000415482ENST00000285871PTPN12chr777227218+CCDC146chr776922269+0.000817450.9991825
ENST00000435495ENST00000431197PTPN12chr777227218+CCDC146chr776922269+0.0016432190.99835676
ENST00000435495ENST00000285871PTPN12chr777227218+CCDC146chr776922269+0.0016432190.99835676

Top

Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>70187_70187_1_PTPN12-CCDC146_PTPN12_chr7_77166962_ENST00000248594_CCDC146_chr7_76908069_ENST00000285871_length(amino acids)=598AA_BP=121
LGVGVGASAAARLVLWESGGCSWKLWCREPSRCRRSRRLGRWGGGGSRGAWRGREGGTCWGNELGKTERALCRAGGRRGGQRPQPGGRGR
MEQVEILRKFIQRVQAMKSPDHNGEDNFARDFMQKYTNIVKEMKAKDLEIRIHKKKKCEIYRRLREFAKLYDTIRNERNKFVNLLHKAHQ
KVNEIKERHKMSLNELEILRNSAVSQERKLQNSMLKHANNVTIRESMQNDVRKIVSKLQEMKEKKEAQLNNIDRLANTITMIEEEMVQLR
KRYEKAVQHRNESGVQLIEREEEICIFYEKINIQEKMKLNGEIEIHLLEEKIQFLKMKIAEKQRQICVTQKLLPAKRSLDADLAVLQIQF
SQCTDRIKDLEKQFVKPDGENRARFLPGKDLTEKEMIQKLDKLELQLAKKEEKLLEKDFIYEQVSRLTDRLCSKTQGCKQDTLLLAKKMN
GYQRRIKNATEKMMALVAELSMKQALTIELQKEVREKEDFIFTCNSRIEKGLPLNKEIEKEWLKVLRDEEMHALAIAEKSQEFLEADNRQ

--------------------------------------------------------------

>70187_70187_2_PTPN12-CCDC146_PTPN12_chr7_77166962_ENST00000248594_CCDC146_chr7_76908069_ENST00000431197_length(amino acids)=598AA_BP=121
LGVGVGASAAARLVLWESGGCSWKLWCREPSRCRRSRRLGRWGGGGSRGAWRGREGGTCWGNELGKTERALCRAGGRRGGQRPQPGGRGR
MEQVEILRKFIQRVQAMKSPDHNGEDNFARDFMQKYTNIVKEMKAKDLEIRIHKKKKCEIYRRLREFAKLYDTIRNERNKFVNLLHKAHQ
KVNEIKERHKMSLNELEILRNSAVSQERKLQNSMLKHANNVTIRESMQNDVRKIVSKLQEMKEKKEAQLNNIDRLANTITMIEEEMVQLR
KRYEKAVQHRNESGVQLIEREEEICIFYEKINIQEKMKLNGEIEIHLLEEKIQFLKMKIAEKQRQICVTQKLLPAKRSLDADLAVLQIQF
SQCTDRIKDLEKQFVKPDGENRARFLPGKDLTEKEMIQKLDKLELQLAKKEEKLLEKDFIYEQVSRLTDRLCSKTQGCKQDTLLLAKKMN
GYQRRIKNATEKMMALVAELSMKQALTIELQKEVREKEDFIFTCNSRIEKGLPLNKEIEKEWLKVLRDEEMHALAIAEKSQEFLEADNRQ

--------------------------------------------------------------

>70187_70187_3_PTPN12-CCDC146_PTPN12_chr7_77227218_ENST00000248594_CCDC146_chr7_76922269_ENST00000285871_length(amino acids)=424AA_BP=274
LGVGVGASAAARLVLWESGGCSWKLWCREPSRCRRSRRLGRWGGGGSRGAWRGREGGTCWGNELGKTERALCRAGGRRGGQRPQPGGRGR
MEQVEILRKFIQRVQAMKSPDHNGEDNFARDFMRLRRLSTKYRTEKIYPTATGEKEENVKKNRYKDILPFDHSRVKLTLKTPSQDSDYIN
ANFIKGVYGPKAYVATQGPLANTVIDFWRMIWEYNVVIIVMACREFEMGRKKCERYWPLYGEDPITFAPFKISCEDEQARTDYFIRTLLL
EFQNMNGYQRRIKNATEKMMALVAELSMKQALTIELQKEVREKEDFIFTCNSRIEKGLPLNKEIEKEWLKVLRDEEMHALAIAEKSQEFL

--------------------------------------------------------------

>70187_70187_4_PTPN12-CCDC146_PTPN12_chr7_77227218_ENST00000248594_CCDC146_chr7_76922269_ENST00000431197_length(amino acids)=424AA_BP=274
LGVGVGASAAARLVLWESGGCSWKLWCREPSRCRRSRRLGRWGGGGSRGAWRGREGGTCWGNELGKTERALCRAGGRRGGQRPQPGGRGR
MEQVEILRKFIQRVQAMKSPDHNGEDNFARDFMRLRRLSTKYRTEKIYPTATGEKEENVKKNRYKDILPFDHSRVKLTLKTPSQDSDYIN
ANFIKGVYGPKAYVATQGPLANTVIDFWRMIWEYNVVIIVMACREFEMGRKKCERYWPLYGEDPITFAPFKISCEDEQARTDYFIRTLLL
EFQNMNGYQRRIKNATEKMMALVAELSMKQALTIELQKEVREKEDFIFTCNSRIEKGLPLNKEIEKEWLKVLRDEEMHALAIAEKSQEFL

--------------------------------------------------------------

>70187_70187_5_PTPN12-CCDC146_PTPN12_chr7_77227218_ENST00000415482_CCDC146_chr7_76922269_ENST00000285871_length(amino acids)=297AA_BP=147
MSTKYRTEKIYPTATGEKEENVKKNRYKDILPFDHSRVKLTLKTPSQDSDYINANFIKGVYGPKAYVATQGPLANTVIDFWRMIWEYNVV
IIVMACREFEMGRKKCERYWPLYGEDPITFAPFKISCEDEQARTDYFIRTLLLEFQNMNGYQRRIKNATEKMMALVAELSMKQALTIELQ
KEVREKEDFIFTCNSRIEKGLPLNKEIEKEWLKVLRDEEMHALAIAEKSQEFLEADNRQLPNGVYTTAEQRPNAYIPEADATLPLPKPYG

--------------------------------------------------------------

>70187_70187_6_PTPN12-CCDC146_PTPN12_chr7_77227218_ENST00000415482_CCDC146_chr7_76922269_ENST00000431197_length(amino acids)=297AA_BP=147
MSTKYRTEKIYPTATGEKEENVKKNRYKDILPFDHSRVKLTLKTPSQDSDYINANFIKGVYGPKAYVATQGPLANTVIDFWRMIWEYNVV
IIVMACREFEMGRKKCERYWPLYGEDPITFAPFKISCEDEQARTDYFIRTLLLEFQNMNGYQRRIKNATEKMMALVAELSMKQALTIELQ
KEVREKEDFIFTCNSRIEKGLPLNKEIEKEWLKVLRDEEMHALAIAEKSQEFLEADNRQLPNGVYTTAEQRPNAYIPEADATLPLPKPYG

--------------------------------------------------------------

>70187_70187_7_PTPN12-CCDC146_PTPN12_chr7_77227218_ENST00000435495_CCDC146_chr7_76922269_ENST00000285871_length(amino acids)=265AA_BP=115
MSTKYRTEKIYPTATGEKEENVKKNRYKDILPFDHSRVKLTLKTPSQDSDYINANFIKIIVMACREFEMGRKKCERYWPLYGEDPITFAP
FKISCEDEQARTDYFIRTLLLEFQNMNGYQRRIKNATEKMMALVAELSMKQALTIELQKEVREKEDFIFTCNSRIEKGLPLNKEIEKEWL

--------------------------------------------------------------

>70187_70187_8_PTPN12-CCDC146_PTPN12_chr7_77227218_ENST00000435495_CCDC146_chr7_76922269_ENST00000431197_length(amino acids)=265AA_BP=115
MSTKYRTEKIYPTATGEKEENVKKNRYKDILPFDHSRVKLTLKTPSQDSDYINANFIKIIVMACREFEMGRKKCERYWPLYGEDPITFAP
FKISCEDEQARTDYFIRTLLLEFQNMNGYQRRIKNATEKMMALVAELSMKQALTIELQKEVREKEDFIFTCNSRIEKGLPLNKEIEKEWL

--------------------------------------------------------------

Top

Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr7:76924255/chr7:77200395)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.CCDC146

Q8IYE0

FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePTPN12chr7:77227218chr7:76922269ENST00000248594+71863_67184.0781.0RegionSubstrate binding
TgeneCCDC146chr7:77166962chr7:76908069ENST000002858711019534_640480.0956.0Coiled coilOntology_term=ECO:0000255
TgeneCCDC146chr7:77166962chr7:76908069ENST000002858711019667_832480.0956.0Coiled coilOntology_term=ECO:0000255
TgeneCCDC146chr7:77166962chr7:76908069ENST00000431197918400_461194.0670.0Coiled coilOntology_term=ECO:0000255
TgeneCCDC146chr7:77166962chr7:76908069ENST00000431197918534_640194.0670.0Coiled coilOntology_term=ECO:0000255
TgeneCCDC146chr7:77166962chr7:76908069ENST00000431197918667_832194.0670.0Coiled coilOntology_term=ECO:0000255
TgeneCCDC146chr7:77227218chr7:76922269ENST000004311971518534_640519.0670.0Coiled coilOntology_term=ECO:0000255
TgeneCCDC146chr7:77227218chr7:76922269ENST000004311971518667_832519.0670.0Coiled coilOntology_term=ECO:0000255
TgeneCCDC146chr7:77166962chr7:76908069ENST000002858711019501_504480.0956.0Compositional biasNote=Poly-Lys
TgeneCCDC146chr7:77166962chr7:76908069ENST00000431197918501_504194.0670.0Compositional biasNote=Poly-Lys

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePTPN12chr7:77166962chr7:76908069ENST00000248594+11828_29333.0781.0DomainTyrosine-protein phosphatase
HgenePTPN12chr7:77166962chr7:76908069ENST00000435495+11728_2930651.0DomainTyrosine-protein phosphatase
HgenePTPN12chr7:77227218chr7:76922269ENST00000248594+71828_293184.0781.0DomainTyrosine-protein phosphatase
HgenePTPN12chr7:77227218chr7:76922269ENST00000435495+61728_29354.0651.0DomainTyrosine-protein phosphatase
HgenePTPN12chr7:77166962chr7:76908069ENST00000248594+118231_23733.0781.0RegionSubstrate binding
HgenePTPN12chr7:77166962chr7:76908069ENST00000248594+11863_6733.0781.0RegionSubstrate binding
HgenePTPN12chr7:77166962chr7:76908069ENST00000435495+117231_2370651.0RegionSubstrate binding
HgenePTPN12chr7:77166962chr7:76908069ENST00000435495+11763_670651.0RegionSubstrate binding
HgenePTPN12chr7:77227218chr7:76922269ENST00000248594+718231_237184.0781.0RegionSubstrate binding
HgenePTPN12chr7:77227218chr7:76922269ENST00000435495+617231_23754.0651.0RegionSubstrate binding
HgenePTPN12chr7:77227218chr7:76922269ENST00000435495+61763_6754.0651.0RegionSubstrate binding
TgeneCCDC146chr7:77166962chr7:76908069ENST000002858711019114_141480.0956.0Coiled coilOntology_term=ECO:0000255
TgeneCCDC146chr7:77166962chr7:76908069ENST000002858711019169_321480.0956.0Coiled coilOntology_term=ECO:0000255
TgeneCCDC146chr7:77166962chr7:76908069ENST000002858711019400_461480.0956.0Coiled coilOntology_term=ECO:0000255
TgeneCCDC146chr7:77166962chr7:76908069ENST00000431197918114_141194.0670.0Coiled coilOntology_term=ECO:0000255
TgeneCCDC146chr7:77166962chr7:76908069ENST00000431197918169_321194.0670.0Coiled coilOntology_term=ECO:0000255
TgeneCCDC146chr7:77227218chr7:76922269ENST000002858711619114_141805.0956.0Coiled coilOntology_term=ECO:0000255
TgeneCCDC146chr7:77227218chr7:76922269ENST000002858711619169_321805.0956.0Coiled coilOntology_term=ECO:0000255
TgeneCCDC146chr7:77227218chr7:76922269ENST000002858711619400_461805.0956.0Coiled coilOntology_term=ECO:0000255
TgeneCCDC146chr7:77227218chr7:76922269ENST000002858711619534_640805.0956.0Coiled coilOntology_term=ECO:0000255
TgeneCCDC146chr7:77227218chr7:76922269ENST000002858711619667_832805.0956.0Coiled coilOntology_term=ECO:0000255
TgeneCCDC146chr7:77227218chr7:76922269ENST000004311971518114_141519.0670.0Coiled coilOntology_term=ECO:0000255
TgeneCCDC146chr7:77227218chr7:76922269ENST000004311971518169_321519.0670.0Coiled coilOntology_term=ECO:0000255
TgeneCCDC146chr7:77227218chr7:76922269ENST000004311971518400_461519.0670.0Coiled coilOntology_term=ECO:0000255
TgeneCCDC146chr7:77166962chr7:76908069ENST00000285871101998_103480.0956.0Compositional biasNote=Poly-Gln
TgeneCCDC146chr7:77166962chr7:76908069ENST0000028587110199_15480.0956.0Compositional biasNote=Poly-Glu
TgeneCCDC146chr7:77166962chr7:76908069ENST0000043119791898_103194.0670.0Compositional biasNote=Poly-Gln
TgeneCCDC146chr7:77166962chr7:76908069ENST000004311979189_15194.0670.0Compositional biasNote=Poly-Glu
TgeneCCDC146chr7:77227218chr7:76922269ENST000002858711619501_504805.0956.0Compositional biasNote=Poly-Lys
TgeneCCDC146chr7:77227218chr7:76922269ENST00000285871161998_103805.0956.0Compositional biasNote=Poly-Gln
TgeneCCDC146chr7:77227218chr7:76922269ENST0000028587116199_15805.0956.0Compositional biasNote=Poly-Glu
TgeneCCDC146chr7:77227218chr7:76922269ENST000004311971518501_504519.0670.0Compositional biasNote=Poly-Lys
TgeneCCDC146chr7:77227218chr7:76922269ENST00000431197151898_103519.0670.0Compositional biasNote=Poly-Gln
TgeneCCDC146chr7:77227218chr7:76922269ENST0000043119715189_15519.0670.0Compositional biasNote=Poly-Glu


Top

Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
PTPN12
CCDC146


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgenePTPN12chr7:77166962chr7:76908069ENST00000248594+118345_43833.0781.0TGFB1I1
HgenePTPN12chr7:77166962chr7:76908069ENST00000435495+117345_4380651.0TGFB1I1
HgenePTPN12chr7:77227218chr7:76922269ENST00000248594+718345_438184.0781.0TGFB1I1
HgenePTPN12chr7:77227218chr7:76922269ENST00000435495+617345_43854.0651.0TGFB1I1


Top

Related Drugs to PTPN12-CCDC146


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

Top

Related Diseases to PTPN12-CCDC146


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource