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Center for Computational Systems Medicine level1
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:PTPRB-MYRFL

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: PTPRB-MYRFL
FusionPDB ID: 70326
FusionGDB2.0 ID: 70326
HgeneTgene
Gene symbol

PTPRB

MYRFL

Gene ID

5787

196446

Gene nameprotein tyrosine phosphatase receptor type Bmyelin regulatory factor like
SynonymsHPTP-BETA|HPTPB|PTPB|R-PTP-BETA|VEPTPC12orf15|C12orf28|bcm1377
Cytomap

12q15

12q15

Type of geneprotein-codingprotein-coding
Descriptionreceptor-type tyrosine-protein phosphatase betaVE-PTPprotein tyrosine phosphatase, receptor type, beta polypeptidevascular endothelial protein tyrosine phosphatasemyelin regulatory factor-like protein
Modification date2020032720200322
UniProtAcc.

Q96LU7

Ensembl transtripts involved in fusion geneENST idsENST00000261266, ENST00000334414, 
ENST00000451516, ENST00000538708, 
ENST00000550358, ENST00000550857, 
ENST00000551525, ENST00000538174, 
ENST00000299350, ENST00000535034, 
ENST00000547771, ENST00000552032, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score2 X 2 X 2=829 X 16 X 7=3248
# samples 226
** MAII scorelog2(2/8*10)=1.32192809488736log2(26/3248*10)=-3.64296810415672
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: PTPRB [Title/Abstract] AND MYRFL [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)PTPRB(70974816)-MYRFL(70345893), # samples:1
Anticipated loss of major functional domain due to fusion event.PTPRB-MYRFL seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
PTPRB-MYRFL seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
PTPRB-MYRFL seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
PTPRB-MYRFL seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgenePTPRB

GO:0016311

dephosphorylation

19116766|19136612


check buttonFusion gene breakpoints across PTPRB (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across MYRFL (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4STADTCGA-BR-A44T-01APTPRBchr12

70974816

-MYRFLchr12

70345893

+


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000451516PTPRBchr1270974816-ENST00000552032MYRFLchr1270345893+2355165402162720
ENST00000451516PTPRBchr1270974816-ENST00000547771MYRFLchr1270345893+2726165402159719
ENST00000451516PTPRBchr1270974816-ENST00000299350MYRFLchr1270345893+2355165402162720
ENST00000451516PTPRBchr1270974816-ENST00000535034MYRFLchr1270345893+2164165402087695
ENST00000334414PTPRBchr1270974816-ENST00000552032MYRFLchr1270345893+332426234531311028
ENST00000334414PTPRBchr1270974816-ENST00000547771MYRFLchr1270345893+369526234531281027
ENST00000334414PTPRBchr1270974816-ENST00000299350MYRFLchr1270345893+332426234531311028
ENST00000334414PTPRBchr1270974816-ENST00000535034MYRFLchr1270345893+313326234530561003
ENST00000550358PTPRBchr1270974816-ENST00000552032MYRFLchr1270345893+330526042631121028
ENST00000550358PTPRBchr1270974816-ENST00000547771MYRFLchr1270345893+367626042631091027
ENST00000550358PTPRBchr1270974816-ENST00000299350MYRFLchr1270345893+330526042631121028
ENST00000550358PTPRBchr1270974816-ENST00000535034MYRFLchr1270345893+311426042630371003
ENST00000538708PTPRBchr1270974816-ENST00000552032MYRFLchr1270345893+26541953202461813
ENST00000538708PTPRBchr1270974816-ENST00000547771MYRFLchr1270345893+30251953202458812
ENST00000538708PTPRBchr1270974816-ENST00000299350MYRFLchr1270345893+26541953202461813
ENST00000538708PTPRBchr1270974816-ENST00000535034MYRFLchr1270345893+24631953202386788
ENST00000550857PTPRBchr1270974816-ENST00000552032MYRFLchr1270345893+23841683202191723
ENST00000550857PTPRBchr1270974816-ENST00000547771MYRFLchr1270345893+27551683202188722
ENST00000550857PTPRBchr1270974816-ENST00000299350MYRFLchr1270345893+23841683202191723
ENST00000550857PTPRBchr1270974816-ENST00000535034MYRFLchr1270345893+21931683202116698
ENST00000261266PTPRBchr1270974816-ENST00000552032MYRFLchr1270345893+26551954212462813
ENST00000261266PTPRBchr1270974816-ENST00000547771MYRFLchr1270345893+30261954212459812
ENST00000261266PTPRBchr1270974816-ENST00000299350MYRFLchr1270345893+26551954212462813
ENST00000261266PTPRBchr1270974816-ENST00000535034MYRFLchr1270345893+24641954212387788
ENST00000551525PTPRBchr1270974816-ENST00000552032MYRFLchr1270345893+330126002531081027
ENST00000551525PTPRBchr1270974816-ENST00000547771MYRFLchr1270345893+367226002531051026
ENST00000551525PTPRBchr1270974816-ENST00000299350MYRFLchr1270345893+330126002531081027
ENST00000551525PTPRBchr1270974816-ENST00000535034MYRFLchr1270345893+311026002530331002

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000451516ENST00000552032PTPRBchr1270974816-MYRFLchr1270345893+0.0002781780.9997218
ENST00000451516ENST00000547771PTPRBchr1270974816-MYRFLchr1270345893+0.0001683170.9998317
ENST00000451516ENST00000299350PTPRBchr1270974816-MYRFLchr1270345893+0.0002781780.9997218
ENST00000451516ENST00000535034PTPRBchr1270974816-MYRFLchr1270345893+0.00058620.99941385
ENST00000334414ENST00000552032PTPRBchr1270974816-MYRFLchr1270345893+0.0002655460.99973446
ENST00000334414ENST00000547771PTPRBchr1270974816-MYRFLchr1270345893+0.0002052230.9997948
ENST00000334414ENST00000299350PTPRBchr1270974816-MYRFLchr1270345893+0.0002655460.99973446
ENST00000334414ENST00000535034PTPRBchr1270974816-MYRFLchr1270345893+0.0006141030.99938583
ENST00000550358ENST00000552032PTPRBchr1270974816-MYRFLchr1270345893+0.0002648820.99973506
ENST00000550358ENST00000547771PTPRBchr1270974816-MYRFLchr1270345893+0.000203370.9997967
ENST00000550358ENST00000299350PTPRBchr1270974816-MYRFLchr1270345893+0.0002648820.99973506
ENST00000550358ENST00000535034PTPRBchr1270974816-MYRFLchr1270345893+0.0006056110.9993944
ENST00000538708ENST00000552032PTPRBchr1270974816-MYRFLchr1270345893+0.00021380.9997862
ENST00000538708ENST00000547771PTPRBchr1270974816-MYRFLchr1270345893+0.0001322090.9998678
ENST00000538708ENST00000299350PTPRBchr1270974816-MYRFLchr1270345893+0.00021380.9997862
ENST00000538708ENST00000535034PTPRBchr1270974816-MYRFLchr1270345893+0.0003374740.9996625
ENST00000550857ENST00000552032PTPRBchr1270974816-MYRFLchr1270345893+0.0002726410.9997273
ENST00000550857ENST00000547771PTPRBchr1270974816-MYRFLchr1270345893+0.0001696950.99983025
ENST00000550857ENST00000299350PTPRBchr1270974816-MYRFLchr1270345893+0.0002726410.9997273
ENST00000550857ENST00000535034PTPRBchr1270974816-MYRFLchr1270345893+0.0005517390.99944824
ENST00000261266ENST00000552032PTPRBchr1270974816-MYRFLchr1270345893+0.0002121920.99978787
ENST00000261266ENST00000547771PTPRBchr1270974816-MYRFLchr1270345893+0.0001312650.99986875
ENST00000261266ENST00000299350PTPRBchr1270974816-MYRFLchr1270345893+0.0002121920.99978787
ENST00000261266ENST00000535034PTPRBchr1270974816-MYRFLchr1270345893+0.000333880.9996661
ENST00000551525ENST00000552032PTPRBchr1270974816-MYRFLchr1270345893+0.0002607040.9997392
ENST00000551525ENST00000547771PTPRBchr1270974816-MYRFLchr1270345893+0.0002026580.9997974
ENST00000551525ENST00000299350PTPRBchr1270974816-MYRFLchr1270345893+0.0002607040.9997392
ENST00000551525ENST00000535034PTPRBchr1270974816-MYRFLchr1270345893+0.0005026390.9994973

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>70326_70326_1_PTPRB-MYRFL_PTPRB_chr12_70974816_ENST00000261266_MYRFL_chr12_70345893_ENST00000299350_length(amino acids)=813AA_BP=644
MSAMLSHGAGLALWITLSLLQTGLAEPERCNFTLAESKASSHSVSIQWRILGSPCNFSLIYSSDTLGAALCPTFRIDNTTYGCNLQDLQA
GTIYNFRIISLDEERTVVLQTDPLPPARFGVSKEKTTSTSLHVWWTPSSGKVTSYEVQLFDENNQKIQGVQIQESTSWNEYTFFNLTAGS
KYNIAITAVSGGKRSFSVYTNGSTVPSPVKDIGISTKANSLLISWSHGSGNVERYRLMLMDKGILVHGGVVDKHATSYAFHGLTPGYLYN
LTVMTEAAGLQNYRWKLVRTAPMEVSNLKVTNDGSLTSLKVKWQRPPGNVDSYNITLSHKGTIKESRVLAPWITETHFKELVPGRLYQVT
VSCVSGELSAQKMAVGRTFPDKVANLEANNNGRMRSLVVSWSPPAGDWEQYRILLFNDSVVLLNITVGKEETQYVMDDTGLVPGRQYEVE
VIVESGNLKNSERCQGRTVPLAVLQLRVKHANETSLSIMWQTPVAEWEKYIISLADRDLLLIHKSLSKDAKEFTFTDLVPGRKYMATVTS
ISGDLKNSSSVKGRTVPAQVTDLHVANQGMTSSLFTNWTQAQGDVEFYQVLLIHENVVIKNESISSETSRYSFHSLKSGSLYSVVVTTVS
GGISSRQVVVEGRTEDKSKSVLARNALSGPDWESDWIDTTISSIQIMEIQQIIDHQYCIQSLQCGSGNYNYNIPVNKHTPTNVKFSLEIN
TTEPLIVFQCKFTLGNICFHSKRGTKGLESHREISQEMTQGYQHIWSLPVAPFSDSMFHFRVAAPDLADCSTDPYFAGIFFTDYFFYFYR

--------------------------------------------------------------

>70326_70326_2_PTPRB-MYRFL_PTPRB_chr12_70974816_ENST00000261266_MYRFL_chr12_70345893_ENST00000535034_length(amino acids)=788AA_BP=644
MSAMLSHGAGLALWITLSLLQTGLAEPERCNFTLAESKASSHSVSIQWRILGSPCNFSLIYSSDTLGAALCPTFRIDNTTYGCNLQDLQA
GTIYNFRIISLDEERTVVLQTDPLPPARFGVSKEKTTSTSLHVWWTPSSGKVTSYEVQLFDENNQKIQGVQIQESTSWNEYTFFNLTAGS
KYNIAITAVSGGKRSFSVYTNGSTVPSPVKDIGISTKANSLLISWSHGSGNVERYRLMLMDKGILVHGGVVDKHATSYAFHGLTPGYLYN
LTVMTEAAGLQNYRWKLVRTAPMEVSNLKVTNDGSLTSLKVKWQRPPGNVDSYNITLSHKGTIKESRVLAPWITETHFKELVPGRLYQVT
VSCVSGELSAQKMAVGRTFPDKVANLEANNNGRMRSLVVSWSPPAGDWEQYRILLFNDSVVLLNITVGKEETQYVMDDTGLVPGRQYEVE
VIVESGNLKNSERCQGRTVPLAVLQLRVKHANETSLSIMWQTPVAEWEKYIISLADRDLLLIHKSLSKDAKEFTFTDLVPGRKYMATVTS
ISGDLKNSSSVKGRTVPAQVTDLHVANQGMTSSLFTNWTQAQGDVEFYQVLLIHENVVIKNESISSETSRYSFHSLKSGSLYSVVVTTVS
GGISSRQVVVEGRTEDKSKSVLARNALSGPDWESDWIDTTISSIQIMEIQQIIDHQYCIQSLQCGTTEPLIVFQCKFTLGNICFHSKRGT

--------------------------------------------------------------

>70326_70326_3_PTPRB-MYRFL_PTPRB_chr12_70974816_ENST00000261266_MYRFL_chr12_70345893_ENST00000547771_length(amino acids)=812AA_BP=644
MSAMLSHGAGLALWITLSLLQTGLAEPERCNFTLAESKASSHSVSIQWRILGSPCNFSLIYSSDTLGAALCPTFRIDNTTYGCNLQDLQA
GTIYNFRIISLDEERTVVLQTDPLPPARFGVSKEKTTSTSLHVWWTPSSGKVTSYEVQLFDENNQKIQGVQIQESTSWNEYTFFNLTAGS
KYNIAITAVSGGKRSFSVYTNGSTVPSPVKDIGISTKANSLLISWSHGSGNVERYRLMLMDKGILVHGGVVDKHATSYAFHGLTPGYLYN
LTVMTEAAGLQNYRWKLVRTAPMEVSNLKVTNDGSLTSLKVKWQRPPGNVDSYNITLSHKGTIKESRVLAPWITETHFKELVPGRLYQVT
VSCVSGELSAQKMAVGRTFPDKVANLEANNNGRMRSLVVSWSPPAGDWEQYRILLFNDSVVLLNITVGKEETQYVMDDTGLVPGRQYEVE
VIVESGNLKNSERCQGRTVPLAVLQLRVKHANETSLSIMWQTPVAEWEKYIISLADRDLLLIHKSLSKDAKEFTFTDLVPGRKYMATVTS
ISGDLKNSSSVKGRTVPAQVTDLHVANQGMTSSLFTNWTQAQGDVEFYQVLLIHENVVIKNESISSETSRYSFHSLKSGSLYSVVVTTVS
GGISSRQVVVEGRTDKSKSVLARNALSGPDWESDWIDTTISSIQIMEIQQIIDHQYCIQSLQCGSGNYNYNIPVNKHTPTNVKFSLEINT
TEPLIVFQCKFTLGNICFHSKRGTKGLESHREISQEMTQGYQHIWSLPVAPFSDSMFHFRVAAPDLADCSTDPYFAGIFFTDYFFYFYRR

--------------------------------------------------------------

>70326_70326_4_PTPRB-MYRFL_PTPRB_chr12_70974816_ENST00000261266_MYRFL_chr12_70345893_ENST00000552032_length(amino acids)=813AA_BP=644
MSAMLSHGAGLALWITLSLLQTGLAEPERCNFTLAESKASSHSVSIQWRILGSPCNFSLIYSSDTLGAALCPTFRIDNTTYGCNLQDLQA
GTIYNFRIISLDEERTVVLQTDPLPPARFGVSKEKTTSTSLHVWWTPSSGKVTSYEVQLFDENNQKIQGVQIQESTSWNEYTFFNLTAGS
KYNIAITAVSGGKRSFSVYTNGSTVPSPVKDIGISTKANSLLISWSHGSGNVERYRLMLMDKGILVHGGVVDKHATSYAFHGLTPGYLYN
LTVMTEAAGLQNYRWKLVRTAPMEVSNLKVTNDGSLTSLKVKWQRPPGNVDSYNITLSHKGTIKESRVLAPWITETHFKELVPGRLYQVT
VSCVSGELSAQKMAVGRTFPDKVANLEANNNGRMRSLVVSWSPPAGDWEQYRILLFNDSVVLLNITVGKEETQYVMDDTGLVPGRQYEVE
VIVESGNLKNSERCQGRTVPLAVLQLRVKHANETSLSIMWQTPVAEWEKYIISLADRDLLLIHKSLSKDAKEFTFTDLVPGRKYMATVTS
ISGDLKNSSSVKGRTVPAQVTDLHVANQGMTSSLFTNWTQAQGDVEFYQVLLIHENVVIKNESISSETSRYSFHSLKSGSLYSVVVTTVS
GGISSRQVVVEGRTEDKSKSVLARNALSGPDWESDWIDTTISSIQIMEIQQIIDHQYCIQSLQCGSGNYNYNIPVNKHTPTNVKFSLEIN
TTEPLIVFQCKFTLGNICFHSKRGTKGLESHREISQEMTQGYQHIWSLPVAPFSDSMFHFRVAAPDLADCSTDPYFAGIFFTDYFFYFYR

--------------------------------------------------------------

>70326_70326_5_PTPRB-MYRFL_PTPRB_chr12_70974816_ENST00000334414_MYRFL_chr12_70345893_ENST00000299350_length(amino acids)=1028AA_BP=859
MEAEFYMVILTCLIFRNSEGFQIVHVQKQQCLFKNEKVVVGSCNRTIQNQQWMWTEDEKLLHVKSALCLAISNSSRGPSRSAILDRCSQA
PRWTCYDQEGFLEVENASLFLQKQGSRVVVKKARKYLHSWMKIDVNKEGKLVNESLCLQKAGLGAEVSVRSTRNTAPPQILTTFNAVPDG
LVFLIRNTTEAFIRNAAENYSQNSSERQHPNLHMTGITDTSWVLSTTQPFSSTTEETGLAEPERCNFTLAESKASSHSVSIQWRILGSPC
NFSLIYSSDTLGAALCPTFRIDNTTYGCNLQDLQAGTIYNFRIISLDEERTVVLQTDPLPPARFGVSKEKTTSTSLHVWWTPSSGKVTSY
EVQLFDENNQKIQGVQIQESTSWNEYTFFNLTAGSKYNIAITAVSGGKRSFSVYTNGSTVPSPVKDIGISTKANSLLISWSHGSGNVERY
RLMLMDKGILVHGGVVDKHATSYAFHGLTPGYLYNLTVMTEAAGLQNYRWKLVRTAPMEVSNLKVTNDGSLTSLKVKWQRPPGNVDSYNI
TLSHKGTIKESRVLAPWITETHFKELVPGRLYQVTVSCVSGELSAQKMAVGRTFPDKVANLEANNNGRMRSLVVSWSPPAGDWEQYRILL
FNDSVVLLNITVGKEETQYVMDDTGLVPGRQYEVEVIVESGNLKNSERCQGRTVPLAVLQLRVKHANETSLSIMWQTPVAEWEKYIISLA
DRDLLLIHKSLSKDAKEFTFTDLVPGRKYMATVTSISGDLKNSSSVKGRTVPAQVTDLHVANQGMTSSLFTNWTQAQGDVEFYQVLLIHE
NVVIKNESISSETSRYSFHSLKSGSLYSVVVTTVSGGISSRQVVVEGRTEDKSKSVLARNALSGPDWESDWIDTTISSIQIMEIQQIIDH
QYCIQSLQCGSGNYNYNIPVNKHTPTNVKFSLEINTTEPLIVFQCKFTLGNICFHSKRGTKGLESHREISQEMTQGYQHIWSLPVAPFSD

--------------------------------------------------------------

>70326_70326_6_PTPRB-MYRFL_PTPRB_chr12_70974816_ENST00000334414_MYRFL_chr12_70345893_ENST00000535034_length(amino acids)=1003AA_BP=859
MEAEFYMVILTCLIFRNSEGFQIVHVQKQQCLFKNEKVVVGSCNRTIQNQQWMWTEDEKLLHVKSALCLAISNSSRGPSRSAILDRCSQA
PRWTCYDQEGFLEVENASLFLQKQGSRVVVKKARKYLHSWMKIDVNKEGKLVNESLCLQKAGLGAEVSVRSTRNTAPPQILTTFNAVPDG
LVFLIRNTTEAFIRNAAENYSQNSSERQHPNLHMTGITDTSWVLSTTQPFSSTTEETGLAEPERCNFTLAESKASSHSVSIQWRILGSPC
NFSLIYSSDTLGAALCPTFRIDNTTYGCNLQDLQAGTIYNFRIISLDEERTVVLQTDPLPPARFGVSKEKTTSTSLHVWWTPSSGKVTSY
EVQLFDENNQKIQGVQIQESTSWNEYTFFNLTAGSKYNIAITAVSGGKRSFSVYTNGSTVPSPVKDIGISTKANSLLISWSHGSGNVERY
RLMLMDKGILVHGGVVDKHATSYAFHGLTPGYLYNLTVMTEAAGLQNYRWKLVRTAPMEVSNLKVTNDGSLTSLKVKWQRPPGNVDSYNI
TLSHKGTIKESRVLAPWITETHFKELVPGRLYQVTVSCVSGELSAQKMAVGRTFPDKVANLEANNNGRMRSLVVSWSPPAGDWEQYRILL
FNDSVVLLNITVGKEETQYVMDDTGLVPGRQYEVEVIVESGNLKNSERCQGRTVPLAVLQLRVKHANETSLSIMWQTPVAEWEKYIISLA
DRDLLLIHKSLSKDAKEFTFTDLVPGRKYMATVTSISGDLKNSSSVKGRTVPAQVTDLHVANQGMTSSLFTNWTQAQGDVEFYQVLLIHE
NVVIKNESISSETSRYSFHSLKSGSLYSVVVTTVSGGISSRQVVVEGRTEDKSKSVLARNALSGPDWESDWIDTTISSIQIMEIQQIIDH
QYCIQSLQCGTTEPLIVFQCKFTLGNICFHSKRGTKGLESHREISQEMTQGYQHIWSLPVAPFSDSMFHFRVAAPDLADCSTDPYFAGIF

--------------------------------------------------------------

>70326_70326_7_PTPRB-MYRFL_PTPRB_chr12_70974816_ENST00000334414_MYRFL_chr12_70345893_ENST00000547771_length(amino acids)=1027AA_BP=859
MEAEFYMVILTCLIFRNSEGFQIVHVQKQQCLFKNEKVVVGSCNRTIQNQQWMWTEDEKLLHVKSALCLAISNSSRGPSRSAILDRCSQA
PRWTCYDQEGFLEVENASLFLQKQGSRVVVKKARKYLHSWMKIDVNKEGKLVNESLCLQKAGLGAEVSVRSTRNTAPPQILTTFNAVPDG
LVFLIRNTTEAFIRNAAENYSQNSSERQHPNLHMTGITDTSWVLSTTQPFSSTTEETGLAEPERCNFTLAESKASSHSVSIQWRILGSPC
NFSLIYSSDTLGAALCPTFRIDNTTYGCNLQDLQAGTIYNFRIISLDEERTVVLQTDPLPPARFGVSKEKTTSTSLHVWWTPSSGKVTSY
EVQLFDENNQKIQGVQIQESTSWNEYTFFNLTAGSKYNIAITAVSGGKRSFSVYTNGSTVPSPVKDIGISTKANSLLISWSHGSGNVERY
RLMLMDKGILVHGGVVDKHATSYAFHGLTPGYLYNLTVMTEAAGLQNYRWKLVRTAPMEVSNLKVTNDGSLTSLKVKWQRPPGNVDSYNI
TLSHKGTIKESRVLAPWITETHFKELVPGRLYQVTVSCVSGELSAQKMAVGRTFPDKVANLEANNNGRMRSLVVSWSPPAGDWEQYRILL
FNDSVVLLNITVGKEETQYVMDDTGLVPGRQYEVEVIVESGNLKNSERCQGRTVPLAVLQLRVKHANETSLSIMWQTPVAEWEKYIISLA
DRDLLLIHKSLSKDAKEFTFTDLVPGRKYMATVTSISGDLKNSSSVKGRTVPAQVTDLHVANQGMTSSLFTNWTQAQGDVEFYQVLLIHE
NVVIKNESISSETSRYSFHSLKSGSLYSVVVTTVSGGISSRQVVVEGRTDKSKSVLARNALSGPDWESDWIDTTISSIQIMEIQQIIDHQ
YCIQSLQCGSGNYNYNIPVNKHTPTNVKFSLEINTTEPLIVFQCKFTLGNICFHSKRGTKGLESHREISQEMTQGYQHIWSLPVAPFSDS

--------------------------------------------------------------

>70326_70326_8_PTPRB-MYRFL_PTPRB_chr12_70974816_ENST00000334414_MYRFL_chr12_70345893_ENST00000552032_length(amino acids)=1028AA_BP=859
MEAEFYMVILTCLIFRNSEGFQIVHVQKQQCLFKNEKVVVGSCNRTIQNQQWMWTEDEKLLHVKSALCLAISNSSRGPSRSAILDRCSQA
PRWTCYDQEGFLEVENASLFLQKQGSRVVVKKARKYLHSWMKIDVNKEGKLVNESLCLQKAGLGAEVSVRSTRNTAPPQILTTFNAVPDG
LVFLIRNTTEAFIRNAAENYSQNSSERQHPNLHMTGITDTSWVLSTTQPFSSTTEETGLAEPERCNFTLAESKASSHSVSIQWRILGSPC
NFSLIYSSDTLGAALCPTFRIDNTTYGCNLQDLQAGTIYNFRIISLDEERTVVLQTDPLPPARFGVSKEKTTSTSLHVWWTPSSGKVTSY
EVQLFDENNQKIQGVQIQESTSWNEYTFFNLTAGSKYNIAITAVSGGKRSFSVYTNGSTVPSPVKDIGISTKANSLLISWSHGSGNVERY
RLMLMDKGILVHGGVVDKHATSYAFHGLTPGYLYNLTVMTEAAGLQNYRWKLVRTAPMEVSNLKVTNDGSLTSLKVKWQRPPGNVDSYNI
TLSHKGTIKESRVLAPWITETHFKELVPGRLYQVTVSCVSGELSAQKMAVGRTFPDKVANLEANNNGRMRSLVVSWSPPAGDWEQYRILL
FNDSVVLLNITVGKEETQYVMDDTGLVPGRQYEVEVIVESGNLKNSERCQGRTVPLAVLQLRVKHANETSLSIMWQTPVAEWEKYIISLA
DRDLLLIHKSLSKDAKEFTFTDLVPGRKYMATVTSISGDLKNSSSVKGRTVPAQVTDLHVANQGMTSSLFTNWTQAQGDVEFYQVLLIHE
NVVIKNESISSETSRYSFHSLKSGSLYSVVVTTVSGGISSRQVVVEGRTEDKSKSVLARNALSGPDWESDWIDTTISSIQIMEIQQIIDH
QYCIQSLQCGSGNYNYNIPVNKHTPTNVKFSLEINTTEPLIVFQCKFTLGNICFHSKRGTKGLESHREISQEMTQGYQHIWSLPVAPFSD

--------------------------------------------------------------

>70326_70326_9_PTPRB-MYRFL_PTPRB_chr12_70974816_ENST00000451516_MYRFL_chr12_70345893_ENST00000299350_length(amino acids)=720AA_BP=551
MLSHGAGLALWITLSLLQTGLAEPERCNFTLAESKASSHSVSIQWRILGSPCNFSLIYSSDTLGAALCPTFRIDNTTYGCNLQDLQAGTI
YNFRIISLDEERTVVLQTDPLPPARFGVSKEKTTSTSLHVWWTPSSGKVTSYEVQLFDENNQKIQGVQIQESTSWNEYTFFNLTAGSKYN
IAITAVSGGKRSFSVYTNGSTVPSPVKDIGISTKANSLLISWSHGSGNVERYRLMLMDKGILVHGGVVDKHATSYAFHGLTPGYLYNLTV
MTEAAGLQNYRWKLVRTAPMEVSNLKVTNDGSLTSLKVKWQRPPGNVDSYNITLSHKGTIKESRVLAPWITETHFKELVPGRLYQVTVSC
VSGELSAQKMAVGRTFPLAVLQLRVKHANETSLSIMWQTPVAEWEKYIISLADRDLLLIHKSLSKDAKEFTFTDLVPGRKYMATVTSISG
DLKNSSSVKGRTVPAQVTDLHVANQGMTSSLFTNWTQAQGDVEFYQVLLIHENVVIKNESISSETSRYSFHSLKSGSLYSVVVTTVSGGI
SSRQVVVEGRTEDKSKSVLARNALSGPDWESDWIDTTISSIQIMEIQQIIDHQYCIQSLQCGSGNYNYNIPVNKHTPTNVKFSLEINTTE
PLIVFQCKFTLGNICFHSKRGTKGLESHREISQEMTQGYQHIWSLPVAPFSDSMFHFRVAAPDLADCSTDPYFAGIFFTDYFFYFYRRCA

--------------------------------------------------------------

>70326_70326_10_PTPRB-MYRFL_PTPRB_chr12_70974816_ENST00000451516_MYRFL_chr12_70345893_ENST00000535034_length(amino acids)=695AA_BP=551
MLSHGAGLALWITLSLLQTGLAEPERCNFTLAESKASSHSVSIQWRILGSPCNFSLIYSSDTLGAALCPTFRIDNTTYGCNLQDLQAGTI
YNFRIISLDEERTVVLQTDPLPPARFGVSKEKTTSTSLHVWWTPSSGKVTSYEVQLFDENNQKIQGVQIQESTSWNEYTFFNLTAGSKYN
IAITAVSGGKRSFSVYTNGSTVPSPVKDIGISTKANSLLISWSHGSGNVERYRLMLMDKGILVHGGVVDKHATSYAFHGLTPGYLYNLTV
MTEAAGLQNYRWKLVRTAPMEVSNLKVTNDGSLTSLKVKWQRPPGNVDSYNITLSHKGTIKESRVLAPWITETHFKELVPGRLYQVTVSC
VSGELSAQKMAVGRTFPLAVLQLRVKHANETSLSIMWQTPVAEWEKYIISLADRDLLLIHKSLSKDAKEFTFTDLVPGRKYMATVTSISG
DLKNSSSVKGRTVPAQVTDLHVANQGMTSSLFTNWTQAQGDVEFYQVLLIHENVVIKNESISSETSRYSFHSLKSGSLYSVVVTTVSGGI
SSRQVVVEGRTEDKSKSVLARNALSGPDWESDWIDTTISSIQIMEIQQIIDHQYCIQSLQCGTTEPLIVFQCKFTLGNICFHSKRGTKGL

--------------------------------------------------------------

>70326_70326_11_PTPRB-MYRFL_PTPRB_chr12_70974816_ENST00000451516_MYRFL_chr12_70345893_ENST00000547771_length(amino acids)=719AA_BP=551
MLSHGAGLALWITLSLLQTGLAEPERCNFTLAESKASSHSVSIQWRILGSPCNFSLIYSSDTLGAALCPTFRIDNTTYGCNLQDLQAGTI
YNFRIISLDEERTVVLQTDPLPPARFGVSKEKTTSTSLHVWWTPSSGKVTSYEVQLFDENNQKIQGVQIQESTSWNEYTFFNLTAGSKYN
IAITAVSGGKRSFSVYTNGSTVPSPVKDIGISTKANSLLISWSHGSGNVERYRLMLMDKGILVHGGVVDKHATSYAFHGLTPGYLYNLTV
MTEAAGLQNYRWKLVRTAPMEVSNLKVTNDGSLTSLKVKWQRPPGNVDSYNITLSHKGTIKESRVLAPWITETHFKELVPGRLYQVTVSC
VSGELSAQKMAVGRTFPLAVLQLRVKHANETSLSIMWQTPVAEWEKYIISLADRDLLLIHKSLSKDAKEFTFTDLVPGRKYMATVTSISG
DLKNSSSVKGRTVPAQVTDLHVANQGMTSSLFTNWTQAQGDVEFYQVLLIHENVVIKNESISSETSRYSFHSLKSGSLYSVVVTTVSGGI
SSRQVVVEGRTDKSKSVLARNALSGPDWESDWIDTTISSIQIMEIQQIIDHQYCIQSLQCGSGNYNYNIPVNKHTPTNVKFSLEINTTEP

--------------------------------------------------------------

>70326_70326_12_PTPRB-MYRFL_PTPRB_chr12_70974816_ENST00000451516_MYRFL_chr12_70345893_ENST00000552032_length(amino acids)=720AA_BP=551
MLSHGAGLALWITLSLLQTGLAEPERCNFTLAESKASSHSVSIQWRILGSPCNFSLIYSSDTLGAALCPTFRIDNTTYGCNLQDLQAGTI
YNFRIISLDEERTVVLQTDPLPPARFGVSKEKTTSTSLHVWWTPSSGKVTSYEVQLFDENNQKIQGVQIQESTSWNEYTFFNLTAGSKYN
IAITAVSGGKRSFSVYTNGSTVPSPVKDIGISTKANSLLISWSHGSGNVERYRLMLMDKGILVHGGVVDKHATSYAFHGLTPGYLYNLTV
MTEAAGLQNYRWKLVRTAPMEVSNLKVTNDGSLTSLKVKWQRPPGNVDSYNITLSHKGTIKESRVLAPWITETHFKELVPGRLYQVTVSC
VSGELSAQKMAVGRTFPLAVLQLRVKHANETSLSIMWQTPVAEWEKYIISLADRDLLLIHKSLSKDAKEFTFTDLVPGRKYMATVTSISG
DLKNSSSVKGRTVPAQVTDLHVANQGMTSSLFTNWTQAQGDVEFYQVLLIHENVVIKNESISSETSRYSFHSLKSGSLYSVVVTTVSGGI
SSRQVVVEGRTEDKSKSVLARNALSGPDWESDWIDTTISSIQIMEIQQIIDHQYCIQSLQCGSGNYNYNIPVNKHTPTNVKFSLEINTTE
PLIVFQCKFTLGNICFHSKRGTKGLESHREISQEMTQGYQHIWSLPVAPFSDSMFHFRVAAPDLADCSTDPYFAGIFFTDYFFYFYRRCA

--------------------------------------------------------------

>70326_70326_13_PTPRB-MYRFL_PTPRB_chr12_70974816_ENST00000538708_MYRFL_chr12_70345893_ENST00000299350_length(amino acids)=813AA_BP=644
MSAMLSHGAGLALWITLSLLQTGLAEPERCNFTLAESKASSHSVSIQWRILGSPCNFSLIYSSDTLGAALCPTFRIDNTTYGCNLQDLQA
GTIYNFRIISLDEERTVVLQTDPLPPARFGVSKEKTTSTSLHVWWTPSSGKVTSYEVQLFDENNQKIQGVQIQESTSWNEYTFFNLTAGS
KYNIAITAVSGGKRSFSVYTNGSTVPSPVKDIGISTKANSLLISWSHGSGNVERYRLMLMDKGILVHGGVVDKHATSYAFHGLTPGYLYN
LTVMTEAAGLQNYRWKLVRTAPMEVSNLKVTNDGSLTSLKVKWQRPPGNVDSYNITLSHKGTIKESRVLAPWITETHFKELVPGRLYQVT
VSCVSGELSAQKMAVGRTFPDKVANLEANNNGRMRSLVVSWSPPAGDWEQYRILLFNDSVVLLNITVGKEETQYVMDDTGLVPGRQYEVE
VIVESGNLKNSERCQGRTVPLAVLQLRVKHANETSLSIMWQTPVAEWEKYIISLADRDLLLIHKSLSKDAKEFTFTDLVPGRKYMATVTS
ISGDLKNSSSVKGRTVPAQVTDLHVANQGMTSSLFTNWTQAQGDVEFYQVLLIHENVVIKNESISSETSRYSFHSLKSGSLYSVVVTTVS
GGISSRQVVVEGRTEDKSKSVLARNALSGPDWESDWIDTTISSIQIMEIQQIIDHQYCIQSLQCGSGNYNYNIPVNKHTPTNVKFSLEIN
TTEPLIVFQCKFTLGNICFHSKRGTKGLESHREISQEMTQGYQHIWSLPVAPFSDSMFHFRVAAPDLADCSTDPYFAGIFFTDYFFYFYR

--------------------------------------------------------------

>70326_70326_14_PTPRB-MYRFL_PTPRB_chr12_70974816_ENST00000538708_MYRFL_chr12_70345893_ENST00000535034_length(amino acids)=788AA_BP=644
MSAMLSHGAGLALWITLSLLQTGLAEPERCNFTLAESKASSHSVSIQWRILGSPCNFSLIYSSDTLGAALCPTFRIDNTTYGCNLQDLQA
GTIYNFRIISLDEERTVVLQTDPLPPARFGVSKEKTTSTSLHVWWTPSSGKVTSYEVQLFDENNQKIQGVQIQESTSWNEYTFFNLTAGS
KYNIAITAVSGGKRSFSVYTNGSTVPSPVKDIGISTKANSLLISWSHGSGNVERYRLMLMDKGILVHGGVVDKHATSYAFHGLTPGYLYN
LTVMTEAAGLQNYRWKLVRTAPMEVSNLKVTNDGSLTSLKVKWQRPPGNVDSYNITLSHKGTIKESRVLAPWITETHFKELVPGRLYQVT
VSCVSGELSAQKMAVGRTFPDKVANLEANNNGRMRSLVVSWSPPAGDWEQYRILLFNDSVVLLNITVGKEETQYVMDDTGLVPGRQYEVE
VIVESGNLKNSERCQGRTVPLAVLQLRVKHANETSLSIMWQTPVAEWEKYIISLADRDLLLIHKSLSKDAKEFTFTDLVPGRKYMATVTS
ISGDLKNSSSVKGRTVPAQVTDLHVANQGMTSSLFTNWTQAQGDVEFYQVLLIHENVVIKNESISSETSRYSFHSLKSGSLYSVVVTTVS
GGISSRQVVVEGRTEDKSKSVLARNALSGPDWESDWIDTTISSIQIMEIQQIIDHQYCIQSLQCGTTEPLIVFQCKFTLGNICFHSKRGT

--------------------------------------------------------------

>70326_70326_15_PTPRB-MYRFL_PTPRB_chr12_70974816_ENST00000538708_MYRFL_chr12_70345893_ENST00000547771_length(amino acids)=812AA_BP=644
MSAMLSHGAGLALWITLSLLQTGLAEPERCNFTLAESKASSHSVSIQWRILGSPCNFSLIYSSDTLGAALCPTFRIDNTTYGCNLQDLQA
GTIYNFRIISLDEERTVVLQTDPLPPARFGVSKEKTTSTSLHVWWTPSSGKVTSYEVQLFDENNQKIQGVQIQESTSWNEYTFFNLTAGS
KYNIAITAVSGGKRSFSVYTNGSTVPSPVKDIGISTKANSLLISWSHGSGNVERYRLMLMDKGILVHGGVVDKHATSYAFHGLTPGYLYN
LTVMTEAAGLQNYRWKLVRTAPMEVSNLKVTNDGSLTSLKVKWQRPPGNVDSYNITLSHKGTIKESRVLAPWITETHFKELVPGRLYQVT
VSCVSGELSAQKMAVGRTFPDKVANLEANNNGRMRSLVVSWSPPAGDWEQYRILLFNDSVVLLNITVGKEETQYVMDDTGLVPGRQYEVE
VIVESGNLKNSERCQGRTVPLAVLQLRVKHANETSLSIMWQTPVAEWEKYIISLADRDLLLIHKSLSKDAKEFTFTDLVPGRKYMATVTS
ISGDLKNSSSVKGRTVPAQVTDLHVANQGMTSSLFTNWTQAQGDVEFYQVLLIHENVVIKNESISSETSRYSFHSLKSGSLYSVVVTTVS
GGISSRQVVVEGRTDKSKSVLARNALSGPDWESDWIDTTISSIQIMEIQQIIDHQYCIQSLQCGSGNYNYNIPVNKHTPTNVKFSLEINT
TEPLIVFQCKFTLGNICFHSKRGTKGLESHREISQEMTQGYQHIWSLPVAPFSDSMFHFRVAAPDLADCSTDPYFAGIFFTDYFFYFYRR

--------------------------------------------------------------

>70326_70326_16_PTPRB-MYRFL_PTPRB_chr12_70974816_ENST00000538708_MYRFL_chr12_70345893_ENST00000552032_length(amino acids)=813AA_BP=644
MSAMLSHGAGLALWITLSLLQTGLAEPERCNFTLAESKASSHSVSIQWRILGSPCNFSLIYSSDTLGAALCPTFRIDNTTYGCNLQDLQA
GTIYNFRIISLDEERTVVLQTDPLPPARFGVSKEKTTSTSLHVWWTPSSGKVTSYEVQLFDENNQKIQGVQIQESTSWNEYTFFNLTAGS
KYNIAITAVSGGKRSFSVYTNGSTVPSPVKDIGISTKANSLLISWSHGSGNVERYRLMLMDKGILVHGGVVDKHATSYAFHGLTPGYLYN
LTVMTEAAGLQNYRWKLVRTAPMEVSNLKVTNDGSLTSLKVKWQRPPGNVDSYNITLSHKGTIKESRVLAPWITETHFKELVPGRLYQVT
VSCVSGELSAQKMAVGRTFPDKVANLEANNNGRMRSLVVSWSPPAGDWEQYRILLFNDSVVLLNITVGKEETQYVMDDTGLVPGRQYEVE
VIVESGNLKNSERCQGRTVPLAVLQLRVKHANETSLSIMWQTPVAEWEKYIISLADRDLLLIHKSLSKDAKEFTFTDLVPGRKYMATVTS
ISGDLKNSSSVKGRTVPAQVTDLHVANQGMTSSLFTNWTQAQGDVEFYQVLLIHENVVIKNESISSETSRYSFHSLKSGSLYSVVVTTVS
GGISSRQVVVEGRTEDKSKSVLARNALSGPDWESDWIDTTISSIQIMEIQQIIDHQYCIQSLQCGSGNYNYNIPVNKHTPTNVKFSLEIN
TTEPLIVFQCKFTLGNICFHSKRGTKGLESHREISQEMTQGYQHIWSLPVAPFSDSMFHFRVAAPDLADCSTDPYFAGIFFTDYFFYFYR

--------------------------------------------------------------

>70326_70326_17_PTPRB-MYRFL_PTPRB_chr12_70974816_ENST00000550358_MYRFL_chr12_70345893_ENST00000299350_length(amino acids)=1028AA_BP=859
MEAEFYMVILTCLIFRNSEGFQIVHVQKQQCLFKNEKVVVGSCNRTIQNQQWMWTEDEKLLHVKSALCLAISNSSRGPSRSAILDRCSQA
PRWTCYDQEGFLEVENASLFLQKQGSRVVVKKARKYLHSWMKIDVNKEGKLVNESLCLQKAGLGAEVSVRSTRNTAPPQILTTFNAVPDG
LVFLIRNTTEAFIRNAAENYSQNSSERQHPNLHMTGITDTSWVLSTTQPFSSTTEETGLAEPERCNFTLAESKASSHSVSIQWRILGSPC
NFSLIYSSDTLGAALCPTFRIDNTTYGCNLQDLQAGTIYNFRIISLDEERTVVLQTDPLPPARFGVSKEKTTSTSLHVWWTPSSGKVTSY
EVQLFDENNQKIQGVQIQESTSWNEYTFFNLTAGSKYNIAITAVSGGKRSFSVYTNGSTVPSPVKDIGISTKANSLLISWSHGSGNVERY
RLMLMDKGILVHGGVVDKHATSYAFHGLTPGYLYNLTVMTEAAGLQNYRWKLVRTAPMEVSNLKVTNDGSLTSLKVKWQRPPGNVDSYNI
TLSHKGTIKESRVLAPWITETHFKELVPGRLYQVTVSCVSGELSAQKMAVGRTFPDKVANLEANNNGRMRSLVVSWSPPAGDWEQYRILL
FNDSVVLLNITVGKEETQYVMDDTGLVPGRQYEVEVIVESGNLKNSERCQGRTVPLAVLQLRVKHANETSLSIMWQTPVAEWEKYIISLA
DRDLLLIHKSLSKDAKEFTFTDLVPGRKYMATVTSISGDLKNSSSVKGRTVPAQVTDLHVANQGMTSSLFTNWTQAQGDVEFYQVLLIHE
NVVIKNESISSETSRYSFHSLKSGSLYSVVVTTVSGGISSRQVVVEGRTEDKSKSVLARNALSGPDWESDWIDTTISSIQIMEIQQIIDH
QYCIQSLQCGSGNYNYNIPVNKHTPTNVKFSLEINTTEPLIVFQCKFTLGNICFHSKRGTKGLESHREISQEMTQGYQHIWSLPVAPFSD

--------------------------------------------------------------

>70326_70326_18_PTPRB-MYRFL_PTPRB_chr12_70974816_ENST00000550358_MYRFL_chr12_70345893_ENST00000535034_length(amino acids)=1003AA_BP=859
MEAEFYMVILTCLIFRNSEGFQIVHVQKQQCLFKNEKVVVGSCNRTIQNQQWMWTEDEKLLHVKSALCLAISNSSRGPSRSAILDRCSQA
PRWTCYDQEGFLEVENASLFLQKQGSRVVVKKARKYLHSWMKIDVNKEGKLVNESLCLQKAGLGAEVSVRSTRNTAPPQILTTFNAVPDG
LVFLIRNTTEAFIRNAAENYSQNSSERQHPNLHMTGITDTSWVLSTTQPFSSTTEETGLAEPERCNFTLAESKASSHSVSIQWRILGSPC
NFSLIYSSDTLGAALCPTFRIDNTTYGCNLQDLQAGTIYNFRIISLDEERTVVLQTDPLPPARFGVSKEKTTSTSLHVWWTPSSGKVTSY
EVQLFDENNQKIQGVQIQESTSWNEYTFFNLTAGSKYNIAITAVSGGKRSFSVYTNGSTVPSPVKDIGISTKANSLLISWSHGSGNVERY
RLMLMDKGILVHGGVVDKHATSYAFHGLTPGYLYNLTVMTEAAGLQNYRWKLVRTAPMEVSNLKVTNDGSLTSLKVKWQRPPGNVDSYNI
TLSHKGTIKESRVLAPWITETHFKELVPGRLYQVTVSCVSGELSAQKMAVGRTFPDKVANLEANNNGRMRSLVVSWSPPAGDWEQYRILL
FNDSVVLLNITVGKEETQYVMDDTGLVPGRQYEVEVIVESGNLKNSERCQGRTVPLAVLQLRVKHANETSLSIMWQTPVAEWEKYIISLA
DRDLLLIHKSLSKDAKEFTFTDLVPGRKYMATVTSISGDLKNSSSVKGRTVPAQVTDLHVANQGMTSSLFTNWTQAQGDVEFYQVLLIHE
NVVIKNESISSETSRYSFHSLKSGSLYSVVVTTVSGGISSRQVVVEGRTEDKSKSVLARNALSGPDWESDWIDTTISSIQIMEIQQIIDH
QYCIQSLQCGTTEPLIVFQCKFTLGNICFHSKRGTKGLESHREISQEMTQGYQHIWSLPVAPFSDSMFHFRVAAPDLADCSTDPYFAGIF

--------------------------------------------------------------

>70326_70326_19_PTPRB-MYRFL_PTPRB_chr12_70974816_ENST00000550358_MYRFL_chr12_70345893_ENST00000547771_length(amino acids)=1027AA_BP=859
MEAEFYMVILTCLIFRNSEGFQIVHVQKQQCLFKNEKVVVGSCNRTIQNQQWMWTEDEKLLHVKSALCLAISNSSRGPSRSAILDRCSQA
PRWTCYDQEGFLEVENASLFLQKQGSRVVVKKARKYLHSWMKIDVNKEGKLVNESLCLQKAGLGAEVSVRSTRNTAPPQILTTFNAVPDG
LVFLIRNTTEAFIRNAAENYSQNSSERQHPNLHMTGITDTSWVLSTTQPFSSTTEETGLAEPERCNFTLAESKASSHSVSIQWRILGSPC
NFSLIYSSDTLGAALCPTFRIDNTTYGCNLQDLQAGTIYNFRIISLDEERTVVLQTDPLPPARFGVSKEKTTSTSLHVWWTPSSGKVTSY
EVQLFDENNQKIQGVQIQESTSWNEYTFFNLTAGSKYNIAITAVSGGKRSFSVYTNGSTVPSPVKDIGISTKANSLLISWSHGSGNVERY
RLMLMDKGILVHGGVVDKHATSYAFHGLTPGYLYNLTVMTEAAGLQNYRWKLVRTAPMEVSNLKVTNDGSLTSLKVKWQRPPGNVDSYNI
TLSHKGTIKESRVLAPWITETHFKELVPGRLYQVTVSCVSGELSAQKMAVGRTFPDKVANLEANNNGRMRSLVVSWSPPAGDWEQYRILL
FNDSVVLLNITVGKEETQYVMDDTGLVPGRQYEVEVIVESGNLKNSERCQGRTVPLAVLQLRVKHANETSLSIMWQTPVAEWEKYIISLA
DRDLLLIHKSLSKDAKEFTFTDLVPGRKYMATVTSISGDLKNSSSVKGRTVPAQVTDLHVANQGMTSSLFTNWTQAQGDVEFYQVLLIHE
NVVIKNESISSETSRYSFHSLKSGSLYSVVVTTVSGGISSRQVVVEGRTDKSKSVLARNALSGPDWESDWIDTTISSIQIMEIQQIIDHQ
YCIQSLQCGSGNYNYNIPVNKHTPTNVKFSLEINTTEPLIVFQCKFTLGNICFHSKRGTKGLESHREISQEMTQGYQHIWSLPVAPFSDS

--------------------------------------------------------------

>70326_70326_20_PTPRB-MYRFL_PTPRB_chr12_70974816_ENST00000550358_MYRFL_chr12_70345893_ENST00000552032_length(amino acids)=1028AA_BP=859
MEAEFYMVILTCLIFRNSEGFQIVHVQKQQCLFKNEKVVVGSCNRTIQNQQWMWTEDEKLLHVKSALCLAISNSSRGPSRSAILDRCSQA
PRWTCYDQEGFLEVENASLFLQKQGSRVVVKKARKYLHSWMKIDVNKEGKLVNESLCLQKAGLGAEVSVRSTRNTAPPQILTTFNAVPDG
LVFLIRNTTEAFIRNAAENYSQNSSERQHPNLHMTGITDTSWVLSTTQPFSSTTEETGLAEPERCNFTLAESKASSHSVSIQWRILGSPC
NFSLIYSSDTLGAALCPTFRIDNTTYGCNLQDLQAGTIYNFRIISLDEERTVVLQTDPLPPARFGVSKEKTTSTSLHVWWTPSSGKVTSY
EVQLFDENNQKIQGVQIQESTSWNEYTFFNLTAGSKYNIAITAVSGGKRSFSVYTNGSTVPSPVKDIGISTKANSLLISWSHGSGNVERY
RLMLMDKGILVHGGVVDKHATSYAFHGLTPGYLYNLTVMTEAAGLQNYRWKLVRTAPMEVSNLKVTNDGSLTSLKVKWQRPPGNVDSYNI
TLSHKGTIKESRVLAPWITETHFKELVPGRLYQVTVSCVSGELSAQKMAVGRTFPDKVANLEANNNGRMRSLVVSWSPPAGDWEQYRILL
FNDSVVLLNITVGKEETQYVMDDTGLVPGRQYEVEVIVESGNLKNSERCQGRTVPLAVLQLRVKHANETSLSIMWQTPVAEWEKYIISLA
DRDLLLIHKSLSKDAKEFTFTDLVPGRKYMATVTSISGDLKNSSSVKGRTVPAQVTDLHVANQGMTSSLFTNWTQAQGDVEFYQVLLIHE
NVVIKNESISSETSRYSFHSLKSGSLYSVVVTTVSGGISSRQVVVEGRTEDKSKSVLARNALSGPDWESDWIDTTISSIQIMEIQQIIDH
QYCIQSLQCGSGNYNYNIPVNKHTPTNVKFSLEINTTEPLIVFQCKFTLGNICFHSKRGTKGLESHREISQEMTQGYQHIWSLPVAPFSD

--------------------------------------------------------------

>70326_70326_21_PTPRB-MYRFL_PTPRB_chr12_70974816_ENST00000550857_MYRFL_chr12_70345893_ENST00000299350_length(amino acids)=723AA_BP=554
MSAMLSHGAGLALWITLSLLQTGLAEPERCNFTLAESKASSHSVSIQWRILGSPCNFSLIYSSDTLGAALCPTFRIDNTTYGCNLQDLQA
GTIYNFRIISLDEERTVVLQTDPLPPARFGVSKEKTTSTSLHVWWTPSSGKVTSYEVQLFDENNQKIQGVQIQESTSWNEYTFFNLTAGS
KYNIAITAVSGGKRSFSVYTNGSTVPSPVKDIGISTKANSLLISWSHGSGNVERYRLMLMDKGILVHGGVVDKHATSYAFHGLTPGYLYN
LTVMTEAAGLQNYRWKLVRTAPMEVSNLKVTNDGSLTSLKVKWQRPPGNVDSYNITLSHKGTIKESRVLAPWITETHFKELVPGRLYQVT
VSCVSGELSAQKMAVGRTFPLAVLQLRVKHANETSLSIMWQTPVAEWEKYIISLADRDLLLIHKSLSKDAKEFTFTDLVPGRKYMATVTS
ISGDLKNSSSVKGRTVPAQVTDLHVANQGMTSSLFTNWTQAQGDVEFYQVLLIHENVVIKNESISSETSRYSFHSLKSGSLYSVVVTTVS
GGISSRQVVVEGRTEDKSKSVLARNALSGPDWESDWIDTTISSIQIMEIQQIIDHQYCIQSLQCGSGNYNYNIPVNKHTPTNVKFSLEIN
TTEPLIVFQCKFTLGNICFHSKRGTKGLESHREISQEMTQGYQHIWSLPVAPFSDSMFHFRVAAPDLADCSTDPYFAGIFFTDYFFYFYR

--------------------------------------------------------------

>70326_70326_22_PTPRB-MYRFL_PTPRB_chr12_70974816_ENST00000550857_MYRFL_chr12_70345893_ENST00000535034_length(amino acids)=698AA_BP=554
MSAMLSHGAGLALWITLSLLQTGLAEPERCNFTLAESKASSHSVSIQWRILGSPCNFSLIYSSDTLGAALCPTFRIDNTTYGCNLQDLQA
GTIYNFRIISLDEERTVVLQTDPLPPARFGVSKEKTTSTSLHVWWTPSSGKVTSYEVQLFDENNQKIQGVQIQESTSWNEYTFFNLTAGS
KYNIAITAVSGGKRSFSVYTNGSTVPSPVKDIGISTKANSLLISWSHGSGNVERYRLMLMDKGILVHGGVVDKHATSYAFHGLTPGYLYN
LTVMTEAAGLQNYRWKLVRTAPMEVSNLKVTNDGSLTSLKVKWQRPPGNVDSYNITLSHKGTIKESRVLAPWITETHFKELVPGRLYQVT
VSCVSGELSAQKMAVGRTFPLAVLQLRVKHANETSLSIMWQTPVAEWEKYIISLADRDLLLIHKSLSKDAKEFTFTDLVPGRKYMATVTS
ISGDLKNSSSVKGRTVPAQVTDLHVANQGMTSSLFTNWTQAQGDVEFYQVLLIHENVVIKNESISSETSRYSFHSLKSGSLYSVVVTTVS
GGISSRQVVVEGRTEDKSKSVLARNALSGPDWESDWIDTTISSIQIMEIQQIIDHQYCIQSLQCGTTEPLIVFQCKFTLGNICFHSKRGT

--------------------------------------------------------------

>70326_70326_23_PTPRB-MYRFL_PTPRB_chr12_70974816_ENST00000550857_MYRFL_chr12_70345893_ENST00000547771_length(amino acids)=722AA_BP=554
MSAMLSHGAGLALWITLSLLQTGLAEPERCNFTLAESKASSHSVSIQWRILGSPCNFSLIYSSDTLGAALCPTFRIDNTTYGCNLQDLQA
GTIYNFRIISLDEERTVVLQTDPLPPARFGVSKEKTTSTSLHVWWTPSSGKVTSYEVQLFDENNQKIQGVQIQESTSWNEYTFFNLTAGS
KYNIAITAVSGGKRSFSVYTNGSTVPSPVKDIGISTKANSLLISWSHGSGNVERYRLMLMDKGILVHGGVVDKHATSYAFHGLTPGYLYN
LTVMTEAAGLQNYRWKLVRTAPMEVSNLKVTNDGSLTSLKVKWQRPPGNVDSYNITLSHKGTIKESRVLAPWITETHFKELVPGRLYQVT
VSCVSGELSAQKMAVGRTFPLAVLQLRVKHANETSLSIMWQTPVAEWEKYIISLADRDLLLIHKSLSKDAKEFTFTDLVPGRKYMATVTS
ISGDLKNSSSVKGRTVPAQVTDLHVANQGMTSSLFTNWTQAQGDVEFYQVLLIHENVVIKNESISSETSRYSFHSLKSGSLYSVVVTTVS
GGISSRQVVVEGRTDKSKSVLARNALSGPDWESDWIDTTISSIQIMEIQQIIDHQYCIQSLQCGSGNYNYNIPVNKHTPTNVKFSLEINT
TEPLIVFQCKFTLGNICFHSKRGTKGLESHREISQEMTQGYQHIWSLPVAPFSDSMFHFRVAAPDLADCSTDPYFAGIFFTDYFFYFYRR

--------------------------------------------------------------

>70326_70326_24_PTPRB-MYRFL_PTPRB_chr12_70974816_ENST00000550857_MYRFL_chr12_70345893_ENST00000552032_length(amino acids)=723AA_BP=554
MSAMLSHGAGLALWITLSLLQTGLAEPERCNFTLAESKASSHSVSIQWRILGSPCNFSLIYSSDTLGAALCPTFRIDNTTYGCNLQDLQA
GTIYNFRIISLDEERTVVLQTDPLPPARFGVSKEKTTSTSLHVWWTPSSGKVTSYEVQLFDENNQKIQGVQIQESTSWNEYTFFNLTAGS
KYNIAITAVSGGKRSFSVYTNGSTVPSPVKDIGISTKANSLLISWSHGSGNVERYRLMLMDKGILVHGGVVDKHATSYAFHGLTPGYLYN
LTVMTEAAGLQNYRWKLVRTAPMEVSNLKVTNDGSLTSLKVKWQRPPGNVDSYNITLSHKGTIKESRVLAPWITETHFKELVPGRLYQVT
VSCVSGELSAQKMAVGRTFPLAVLQLRVKHANETSLSIMWQTPVAEWEKYIISLADRDLLLIHKSLSKDAKEFTFTDLVPGRKYMATVTS
ISGDLKNSSSVKGRTVPAQVTDLHVANQGMTSSLFTNWTQAQGDVEFYQVLLIHENVVIKNESISSETSRYSFHSLKSGSLYSVVVTTVS
GGISSRQVVVEGRTEDKSKSVLARNALSGPDWESDWIDTTISSIQIMEIQQIIDHQYCIQSLQCGSGNYNYNIPVNKHTPTNVKFSLEIN
TTEPLIVFQCKFTLGNICFHSKRGTKGLESHREISQEMTQGYQHIWSLPVAPFSDSMFHFRVAAPDLADCSTDPYFAGIFFTDYFFYFYR

--------------------------------------------------------------

>70326_70326_25_PTPRB-MYRFL_PTPRB_chr12_70974816_ENST00000551525_MYRFL_chr12_70345893_ENST00000299350_length(amino acids)=1027AA_BP=858
MEAEFYMVILTCLIFRNSGFQIVHVQKQQCLFKNEKVVVGSCNRTIQNQQWMWTEDEKLLHVKSALCLAISNSSRGPSRSAILDRCSQAP
RWTCYDQEGFLEVENASLFLQKQGSRVVVKKARKYLHSWMKIDVNKEGKLVNESLCLQKAGLGAEVSVRSTRNTAPPQILTTFNAVPDGL
VFLIRNTTEAFIRNAAENYSQNSSERQHPNLHMTGITDTSWVLSTTQPFSSTTEETGLAEPERCNFTLAESKASSHSVSIQWRILGSPCN
FSLIYSSDTLGAALCPTFRIDNTTYGCNLQDLQAGTIYNFRIISLDEERTVVLQTDPLPPARFGVSKEKTTSTSLHVWWTPSSGKVTSYE
VQLFDENNQKIQGVQIQESTSWNEYTFFNLTAGSKYNIAITAVSGGKRSFSVYTNGSTVPSPVKDIGISTKANSLLISWSHGSGNVERYR
LMLMDKGILVHGGVVDKHATSYAFHGLTPGYLYNLTVMTEAAGLQNYRWKLVRTAPMEVSNLKVTNDGSLTSLKVKWQRPPGNVDSYNIT
LSHKGTIKESRVLAPWITETHFKELVPGRLYQVTVSCVSGELSAQKMAVGRTFPDKVANLEANNNGRMRSLVVSWSPPAGDWEQYRILLF
NDSVVLLNITVGKEETQYVMDDTGLVPGRQYEVEVIVESGNLKNSERCQGRTVPLAVLQLRVKHANETSLSIMWQTPVAEWEKYIISLAD
RDLLLIHKSLSKDAKEFTFTDLVPGRKYMATVTSISGDLKNSSSVKGRTVPAQVTDLHVANQGMTSSLFTNWTQAQGDVEFYQVLLIHEN
VVIKNESISSETSRYSFHSLKSGSLYSVVVTTVSGGISSRQVVVEGRTEDKSKSVLARNALSGPDWESDWIDTTISSIQIMEIQQIIDHQ
YCIQSLQCGSGNYNYNIPVNKHTPTNVKFSLEINTTEPLIVFQCKFTLGNICFHSKRGTKGLESHREISQEMTQGYQHIWSLPVAPFSDS

--------------------------------------------------------------

>70326_70326_26_PTPRB-MYRFL_PTPRB_chr12_70974816_ENST00000551525_MYRFL_chr12_70345893_ENST00000535034_length(amino acids)=1002AA_BP=858
MEAEFYMVILTCLIFRNSGFQIVHVQKQQCLFKNEKVVVGSCNRTIQNQQWMWTEDEKLLHVKSALCLAISNSSRGPSRSAILDRCSQAP
RWTCYDQEGFLEVENASLFLQKQGSRVVVKKARKYLHSWMKIDVNKEGKLVNESLCLQKAGLGAEVSVRSTRNTAPPQILTTFNAVPDGL
VFLIRNTTEAFIRNAAENYSQNSSERQHPNLHMTGITDTSWVLSTTQPFSSTTEETGLAEPERCNFTLAESKASSHSVSIQWRILGSPCN
FSLIYSSDTLGAALCPTFRIDNTTYGCNLQDLQAGTIYNFRIISLDEERTVVLQTDPLPPARFGVSKEKTTSTSLHVWWTPSSGKVTSYE
VQLFDENNQKIQGVQIQESTSWNEYTFFNLTAGSKYNIAITAVSGGKRSFSVYTNGSTVPSPVKDIGISTKANSLLISWSHGSGNVERYR
LMLMDKGILVHGGVVDKHATSYAFHGLTPGYLYNLTVMTEAAGLQNYRWKLVRTAPMEVSNLKVTNDGSLTSLKVKWQRPPGNVDSYNIT
LSHKGTIKESRVLAPWITETHFKELVPGRLYQVTVSCVSGELSAQKMAVGRTFPDKVANLEANNNGRMRSLVVSWSPPAGDWEQYRILLF
NDSVVLLNITVGKEETQYVMDDTGLVPGRQYEVEVIVESGNLKNSERCQGRTVPLAVLQLRVKHANETSLSIMWQTPVAEWEKYIISLAD
RDLLLIHKSLSKDAKEFTFTDLVPGRKYMATVTSISGDLKNSSSVKGRTVPAQVTDLHVANQGMTSSLFTNWTQAQGDVEFYQVLLIHEN
VVIKNESISSETSRYSFHSLKSGSLYSVVVTTVSGGISSRQVVVEGRTEDKSKSVLARNALSGPDWESDWIDTTISSIQIMEIQQIIDHQ
YCIQSLQCGTTEPLIVFQCKFTLGNICFHSKRGTKGLESHREISQEMTQGYQHIWSLPVAPFSDSMFHFRVAAPDLADCSTDPYFAGIFF

--------------------------------------------------------------

>70326_70326_27_PTPRB-MYRFL_PTPRB_chr12_70974816_ENST00000551525_MYRFL_chr12_70345893_ENST00000547771_length(amino acids)=1026AA_BP=858
MEAEFYMVILTCLIFRNSGFQIVHVQKQQCLFKNEKVVVGSCNRTIQNQQWMWTEDEKLLHVKSALCLAISNSSRGPSRSAILDRCSQAP
RWTCYDQEGFLEVENASLFLQKQGSRVVVKKARKYLHSWMKIDVNKEGKLVNESLCLQKAGLGAEVSVRSTRNTAPPQILTTFNAVPDGL
VFLIRNTTEAFIRNAAENYSQNSSERQHPNLHMTGITDTSWVLSTTQPFSSTTEETGLAEPERCNFTLAESKASSHSVSIQWRILGSPCN
FSLIYSSDTLGAALCPTFRIDNTTYGCNLQDLQAGTIYNFRIISLDEERTVVLQTDPLPPARFGVSKEKTTSTSLHVWWTPSSGKVTSYE
VQLFDENNQKIQGVQIQESTSWNEYTFFNLTAGSKYNIAITAVSGGKRSFSVYTNGSTVPSPVKDIGISTKANSLLISWSHGSGNVERYR
LMLMDKGILVHGGVVDKHATSYAFHGLTPGYLYNLTVMTEAAGLQNYRWKLVRTAPMEVSNLKVTNDGSLTSLKVKWQRPPGNVDSYNIT
LSHKGTIKESRVLAPWITETHFKELVPGRLYQVTVSCVSGELSAQKMAVGRTFPDKVANLEANNNGRMRSLVVSWSPPAGDWEQYRILLF
NDSVVLLNITVGKEETQYVMDDTGLVPGRQYEVEVIVESGNLKNSERCQGRTVPLAVLQLRVKHANETSLSIMWQTPVAEWEKYIISLAD
RDLLLIHKSLSKDAKEFTFTDLVPGRKYMATVTSISGDLKNSSSVKGRTVPAQVTDLHVANQGMTSSLFTNWTQAQGDVEFYQVLLIHEN
VVIKNESISSETSRYSFHSLKSGSLYSVVVTTVSGGISSRQVVVEGRTDKSKSVLARNALSGPDWESDWIDTTISSIQIMEIQQIIDHQY
CIQSLQCGSGNYNYNIPVNKHTPTNVKFSLEINTTEPLIVFQCKFTLGNICFHSKRGTKGLESHREISQEMTQGYQHIWSLPVAPFSDSM

--------------------------------------------------------------

>70326_70326_28_PTPRB-MYRFL_PTPRB_chr12_70974816_ENST00000551525_MYRFL_chr12_70345893_ENST00000552032_length(amino acids)=1027AA_BP=858
MEAEFYMVILTCLIFRNSGFQIVHVQKQQCLFKNEKVVVGSCNRTIQNQQWMWTEDEKLLHVKSALCLAISNSSRGPSRSAILDRCSQAP
RWTCYDQEGFLEVENASLFLQKQGSRVVVKKARKYLHSWMKIDVNKEGKLVNESLCLQKAGLGAEVSVRSTRNTAPPQILTTFNAVPDGL
VFLIRNTTEAFIRNAAENYSQNSSERQHPNLHMTGITDTSWVLSTTQPFSSTTEETGLAEPERCNFTLAESKASSHSVSIQWRILGSPCN
FSLIYSSDTLGAALCPTFRIDNTTYGCNLQDLQAGTIYNFRIISLDEERTVVLQTDPLPPARFGVSKEKTTSTSLHVWWTPSSGKVTSYE
VQLFDENNQKIQGVQIQESTSWNEYTFFNLTAGSKYNIAITAVSGGKRSFSVYTNGSTVPSPVKDIGISTKANSLLISWSHGSGNVERYR
LMLMDKGILVHGGVVDKHATSYAFHGLTPGYLYNLTVMTEAAGLQNYRWKLVRTAPMEVSNLKVTNDGSLTSLKVKWQRPPGNVDSYNIT
LSHKGTIKESRVLAPWITETHFKELVPGRLYQVTVSCVSGELSAQKMAVGRTFPDKVANLEANNNGRMRSLVVSWSPPAGDWEQYRILLF
NDSVVLLNITVGKEETQYVMDDTGLVPGRQYEVEVIVESGNLKNSERCQGRTVPLAVLQLRVKHANETSLSIMWQTPVAEWEKYIISLAD
RDLLLIHKSLSKDAKEFTFTDLVPGRKYMATVTSISGDLKNSSSVKGRTVPAQVTDLHVANQGMTSSLFTNWTQAQGDVEFYQVLLIHEN
VVIKNESISSETSRYSFHSLKSGSLYSVVVTTVSGGISSRQVVVEGRTEDKSKSVLARNALSGPDWESDWIDTTISSIQIMEIQQIIDHQ
YCIQSLQCGSGNYNYNIPVNKHTPTNVKFSLEINTTEPLIVFQCKFTLGNICFHSKRGTKGLESHREISQEMTQGYQHIWSLPVAPFSDS

--------------------------------------------------------------

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr12:70974816/chr12:70345893)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.MYRFL

Q96LU7

FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePTPRBchr12:70974816chr12:70345893ENST00000261266-832112_207641.33333333333341998.0DomainFibronectin type-III 2
HgenePTPRBchr12:70974816chr12:70345893ENST00000261266-832203_288641.33333333333341998.0DomainFibronectin type-III 3
HgenePTPRBchr12:70974816chr12:70345893ENST00000261266-83223_111641.33333333333341998.0DomainFibronectin type-III 1
HgenePTPRBchr12:70974816chr12:70345893ENST00000261266-832291_378641.33333333333341998.0DomainFibronectin type-III 4
HgenePTPRBchr12:70974816chr12:70345893ENST00000261266-832379_471641.33333333333341998.0DomainFibronectin type-III 5
HgenePTPRBchr12:70974816chr12:70345893ENST00000261266-832467_552641.33333333333341998.0DomainFibronectin type-III 6
HgenePTPRBchr12:70974816chr12:70345893ENST00000261266-832556_641641.33333333333341998.0DomainFibronectin type-III 7
HgenePTPRBchr12:70974816chr12:70345893ENST00000334414-1034112_207859.33333333333342216.0DomainFibronectin type-III 2
HgenePTPRBchr12:70974816chr12:70345893ENST00000334414-1034203_288859.33333333333342216.0DomainFibronectin type-III 3
HgenePTPRBchr12:70974816chr12:70345893ENST00000334414-103423_111859.33333333333342216.0DomainFibronectin type-III 1
HgenePTPRBchr12:70974816chr12:70345893ENST00000334414-1034291_378859.33333333333342216.0DomainFibronectin type-III 4
HgenePTPRBchr12:70974816chr12:70345893ENST00000334414-1034379_471859.33333333333342216.0DomainFibronectin type-III 5
HgenePTPRBchr12:70974816chr12:70345893ENST00000334414-1034467_552859.33333333333342216.0DomainFibronectin type-III 6
HgenePTPRBchr12:70974816chr12:70345893ENST00000334414-1034556_641859.33333333333342216.0DomainFibronectin type-III 7
HgenePTPRBchr12:70974816chr12:70345893ENST00000334414-1034642_729859.33333333333342216.0DomainFibronectin type-III 8
HgenePTPRBchr12:70974816chr12:70345893ENST00000334414-1034730_829859.33333333333342216.0DomainFibronectin type-III 9
HgenePTPRBchr12:70974816chr12:70345893ENST00000550857-731112_207551.33333333333341908.0DomainFibronectin type-III 2
HgenePTPRBchr12:70974816chr12:70345893ENST00000550857-731203_288551.33333333333341908.0DomainFibronectin type-III 3
HgenePTPRBchr12:70974816chr12:70345893ENST00000550857-73123_111551.33333333333341908.0DomainFibronectin type-III 1
HgenePTPRBchr12:70974816chr12:70345893ENST00000550857-731291_378551.33333333333341908.0DomainFibronectin type-III 4
HgenePTPRBchr12:70974816chr12:70345893ENST00000550857-731379_471551.33333333333341908.0DomainFibronectin type-III 5
HgenePTPRBchr12:70974816chr12:70345893ENST00000550857-731467_552551.33333333333341908.0DomainFibronectin type-III 6

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePTPRBchr12:70974816chr12:70345893ENST00000261266-8321087_1175641.33333333333341998.0DomainFibronectin type-III 13
HgenePTPRBchr12:70974816chr12:70345893ENST00000261266-8321173_1260641.33333333333341998.0DomainFibronectin type-III 14
HgenePTPRBchr12:70974816chr12:70345893ENST00000261266-8321260_1356641.33333333333341998.0DomainFibronectin type-III 15
HgenePTPRBchr12:70974816chr12:70345893ENST00000261266-8321357_1448641.33333333333341998.0DomainFibronectin type-III 16
HgenePTPRBchr12:70974816chr12:70345893ENST00000261266-8321458_1554641.33333333333341998.0DomainFibronectin type-III 17
HgenePTPRBchr12:70974816chr12:70345893ENST00000261266-8321703_1963641.33333333333341998.0DomainTyrosine-protein phosphatase
HgenePTPRBchr12:70974816chr12:70345893ENST00000261266-832642_729641.33333333333341998.0DomainFibronectin type-III 8
HgenePTPRBchr12:70974816chr12:70345893ENST00000261266-832730_829641.33333333333341998.0DomainFibronectin type-III 9
HgenePTPRBchr12:70974816chr12:70345893ENST00000261266-832819_906641.33333333333341998.0DomainFibronectin type-III 10
HgenePTPRBchr12:70974816chr12:70345893ENST00000261266-832909_1001641.33333333333341998.0DomainFibronectin type-III 11
HgenePTPRBchr12:70974816chr12:70345893ENST00000261266-832995_1083641.33333333333341998.0DomainFibronectin type-III 12
HgenePTPRBchr12:70974816chr12:70345893ENST00000334414-10341087_1175859.33333333333342216.0DomainFibronectin type-III 13
HgenePTPRBchr12:70974816chr12:70345893ENST00000334414-10341173_1260859.33333333333342216.0DomainFibronectin type-III 14
HgenePTPRBchr12:70974816chr12:70345893ENST00000334414-10341260_1356859.33333333333342216.0DomainFibronectin type-III 15
HgenePTPRBchr12:70974816chr12:70345893ENST00000334414-10341357_1448859.33333333333342216.0DomainFibronectin type-III 16
HgenePTPRBchr12:70974816chr12:70345893ENST00000334414-10341458_1554859.33333333333342216.0DomainFibronectin type-III 17
HgenePTPRBchr12:70974816chr12:70345893ENST00000334414-10341703_1963859.33333333333342216.0DomainTyrosine-protein phosphatase
HgenePTPRBchr12:70974816chr12:70345893ENST00000334414-1034819_906859.33333333333342216.0DomainFibronectin type-III 10
HgenePTPRBchr12:70974816chr12:70345893ENST00000334414-1034909_1001859.33333333333342216.0DomainFibronectin type-III 11
HgenePTPRBchr12:70974816chr12:70345893ENST00000334414-1034995_1083859.33333333333342216.0DomainFibronectin type-III 12
HgenePTPRBchr12:70974816chr12:70345893ENST00000550857-7311087_1175551.33333333333341908.0DomainFibronectin type-III 13
HgenePTPRBchr12:70974816chr12:70345893ENST00000550857-7311173_1260551.33333333333341908.0DomainFibronectin type-III 14
HgenePTPRBchr12:70974816chr12:70345893ENST00000550857-7311260_1356551.33333333333341908.0DomainFibronectin type-III 15
HgenePTPRBchr12:70974816chr12:70345893ENST00000550857-7311357_1448551.33333333333341908.0DomainFibronectin type-III 16
HgenePTPRBchr12:70974816chr12:70345893ENST00000550857-7311458_1554551.33333333333341908.0DomainFibronectin type-III 17
HgenePTPRBchr12:70974816chr12:70345893ENST00000550857-7311703_1963551.33333333333341908.0DomainTyrosine-protein phosphatase
HgenePTPRBchr12:70974816chr12:70345893ENST00000550857-731556_641551.33333333333341908.0DomainFibronectin type-III 7
HgenePTPRBchr12:70974816chr12:70345893ENST00000550857-731642_729551.33333333333341908.0DomainFibronectin type-III 8
HgenePTPRBchr12:70974816chr12:70345893ENST00000550857-731730_829551.33333333333341908.0DomainFibronectin type-III 9
HgenePTPRBchr12:70974816chr12:70345893ENST00000550857-731819_906551.33333333333341908.0DomainFibronectin type-III 10
HgenePTPRBchr12:70974816chr12:70345893ENST00000550857-731909_1001551.33333333333341908.0DomainFibronectin type-III 11
HgenePTPRBchr12:70974816chr12:70345893ENST00000550857-731995_1083551.33333333333341908.0DomainFibronectin type-III 12
HgenePTPRBchr12:70974816chr12:70345893ENST00000261266-8321904_1910641.33333333333341998.0RegionSubstrate binding
HgenePTPRBchr12:70974816chr12:70345893ENST00000334414-10341904_1910859.33333333333342216.0RegionSubstrate binding
HgenePTPRBchr12:70974816chr12:70345893ENST00000550857-7311904_1910551.33333333333341908.0RegionSubstrate binding
HgenePTPRBchr12:70974816chr12:70345893ENST00000261266-8321643_1997641.33333333333341998.0Topological domainCytoplasmic
HgenePTPRBchr12:70974816chr12:70345893ENST00000261266-83223_1621641.33333333333341998.0Topological domainExtracellular
HgenePTPRBchr12:70974816chr12:70345893ENST00000334414-10341643_1997859.33333333333342216.0Topological domainCytoplasmic
HgenePTPRBchr12:70974816chr12:70345893ENST00000334414-103423_1621859.33333333333342216.0Topological domainExtracellular
HgenePTPRBchr12:70974816chr12:70345893ENST00000550857-7311643_1997551.33333333333341908.0Topological domainCytoplasmic
HgenePTPRBchr12:70974816chr12:70345893ENST00000550857-73123_1621551.33333333333341908.0Topological domainExtracellular
HgenePTPRBchr12:70974816chr12:70345893ENST00000261266-8321622_1642641.33333333333341998.0TransmembraneHelical
HgenePTPRBchr12:70974816chr12:70345893ENST00000334414-10341622_1642859.33333333333342216.0TransmembraneHelical
HgenePTPRBchr12:70974816chr12:70345893ENST00000550857-7311622_1642551.33333333333341908.0TransmembraneHelical
TgeneMYRFLchr12:70974816chr12:70345893ENST000005520321825543_575741.3333333333334911.0Coiled coilOntology_term=ECO:0000255
TgeneMYRFLchr12:70974816chr12:70345893ENST000005520321825142_405741.3333333333334911.0DNA bindingNDT80
TgeneMYRFLchr12:70974816chr12:70345893ENST000005520321825451_559741.3333333333334911.0DomainPeptidase S74
TgeneMYRFLchr12:70974816chr12:70345893ENST000005520321825628_648741.3333333333334911.0TransmembraneHelical


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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
PTPRB
MYRFL


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to PTPRB-MYRFL


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to PTPRB-MYRFL


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource