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Fusion Protein:PTPRD-CDC37L1 |
Fusion Protein Summary |
Fusion gene summary |
Fusion partner gene information | Fusion gene name: PTPRD-CDC37L1 | FusionPDB ID: 70342 | FusionGDB2.0 ID: 70342 | Hgene | Tgene | Gene symbol | PTPRD | CDC37L1 | Gene ID | 5789 | 55664 |
Gene name | protein tyrosine phosphatase receptor type D | cell division cycle 37 like 1 | |
Synonyms | HPTP|HPTPD|HPTPDELTA|PTPD|R-PTP-delta|RPTPDELTA | CDC37B|HARC | |
Cytomap | 9p24.1-p23 | 9p24.1 | |
Type of gene | protein-coding | protein-coding | |
Description | receptor-type tyrosine-protein phosphatase deltaprotein tyrosine phosphatase, receptor type, delta polypeptiderceptor-type tyrosine-protein phosphatase delta | hsp90 co-chaperone Cdc37-like 1CDC37 cell division cycle 37 homolog-like 1Hsp90-associating relative of Cdc37cell division cycle 37 homolog-like 1 | |
Modification date | 20200320 | 20200313 | |
UniProtAcc | . | Q7L3B6 | |
Ensembl transtripts involved in fusion gene | ENST ids | ENST00000355233, ENST00000356435, ENST00000358503, ENST00000360074, ENST00000381196, ENST00000397606, ENST00000397611, ENST00000397617, ENST00000486161, ENST00000537002, ENST00000540109, ENST00000463477, ENST00000471274, | ENST00000479095, ENST00000381854, ENST00000381858, |
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0) | * DoF score | 26 X 25 X 7=4550 | 3 X 3 X 3=27 |
# samples | 28 | 3 | |
** MAII score | log2(28/4550*10)=-4.02236781302845 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(3/27*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
Context (manual curation of fusion genes in FusionPDB) | PubMed: PTPRD [Title/Abstract] AND CDC37L1 [Title/Abstract] AND fusion [Title/Abstract] | ||
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0) | PTPRD(8404537)-CDC37L1(4697096), # samples:1 | ||
Anticipated loss of major functional domain due to fusion event. | PTPRD-CDC37L1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. PTPRD-CDC37L1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. PTPRD-CDC37L1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. PTPRD-CDC37L1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. PTPRD-CDC37L1 seems lost the major protein functional domain in Hgene partner, which is a CGC due to the frame-shifted ORF. PTPRD-CDC37L1 seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF. PTPRD-CDC37L1 seems lost the major protein functional domain in Hgene partner, which is a tumor suppressor due to the frame-shifted ORF. PTPRD-CDC37L1 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF. |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | PTPRD | GO:0099545 | trans-synaptic signaling by trans-synaptic complex | 21926414 |
Hgene | PTPRD | GO:0099560 | synaptic membrane adhesion | 23345436 |
Hgene | PTPRD | GO:1905606 | regulation of presynapse assembly | 21926414 |
Fusion gene breakpoints across PTPRD (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
Fusion gene breakpoints across CDC37L1 (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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Fusion Gene Sample Information |
Fusion gene information from FusionGDB2.0. |
Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChimerDB4 | GBM | TCGA-06-0174-01A | PTPRD | chr9 | 8404537 | - | CDC37L1 | chr9 | 4697096 | + |
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Fusion ORF Analysis |
Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB. |
Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
ENST00000360074 | PTPRD | chr9 | 8404537 | - | ENST00000381858 | CDC37L1 | chr9 | 4697096 | + | 4801 | 4274 | 85 | 4692 | 1535 |
ENST00000360074 | PTPRD | chr9 | 8404537 | - | ENST00000381854 | CDC37L1 | chr9 | 4697096 | + | 7066 | 4274 | 85 | 4779 | 1564 |
ENST00000537002 | PTPRD | chr9 | 8404537 | - | ENST00000381858 | CDC37L1 | chr9 | 4697096 | + | 3610 | 3083 | 85 | 3501 | 1138 |
ENST00000537002 | PTPRD | chr9 | 8404537 | - | ENST00000381854 | CDC37L1 | chr9 | 4697096 | + | 5875 | 3083 | 85 | 3588 | 1167 |
ENST00000397617 | PTPRD | chr9 | 8404537 | - | ENST00000381858 | CDC37L1 | chr9 | 4697096 | + | 3619 | 3092 | 85 | 3510 | 1141 |
ENST00000397617 | PTPRD | chr9 | 8404537 | - | ENST00000381854 | CDC37L1 | chr9 | 4697096 | + | 5884 | 3092 | 85 | 3597 | 1170 |
ENST00000358503 | PTPRD | chr9 | 8404537 | - | ENST00000381858 | CDC37L1 | chr9 | 4697096 | + | 4774 | 4247 | 85 | 4665 | 1526 |
ENST00000358503 | PTPRD | chr9 | 8404537 | - | ENST00000381854 | CDC37L1 | chr9 | 4697096 | + | 7039 | 4247 | 85 | 4752 | 1555 |
ENST00000397611 | PTPRD | chr9 | 8404537 | - | ENST00000381858 | CDC37L1 | chr9 | 4697096 | + | 3610 | 3083 | 85 | 3501 | 1138 |
ENST00000397611 | PTPRD | chr9 | 8404537 | - | ENST00000381854 | CDC37L1 | chr9 | 4697096 | + | 5875 | 3083 | 85 | 3588 | 1167 |
ENST00000355233 | PTPRD | chr9 | 8404537 | - | ENST00000381858 | CDC37L1 | chr9 | 4697096 | + | 3622 | 3095 | 85 | 3513 | 1142 |
ENST00000355233 | PTPRD | chr9 | 8404537 | - | ENST00000381854 | CDC37L1 | chr9 | 4697096 | + | 5887 | 3095 | 85 | 3600 | 1171 |
ENST00000356435 | PTPRD | chr9 | 8404537 | - | ENST00000381858 | CDC37L1 | chr9 | 4697096 | + | 4843 | 4316 | 88 | 4734 | 1548 |
ENST00000356435 | PTPRD | chr9 | 8404537 | - | ENST00000381854 | CDC37L1 | chr9 | 4697096 | + | 7108 | 4316 | 88 | 4821 | 1577 |
ENST00000486161 | PTPRD | chr9 | 8404537 | - | ENST00000381858 | CDC37L1 | chr9 | 4697096 | + | 3567 | 3040 | 33 | 3458 | 1141 |
ENST00000486161 | PTPRD | chr9 | 8404537 | - | ENST00000381854 | CDC37L1 | chr9 | 4697096 | + | 5832 | 3040 | 33 | 3545 | 1170 |
ENST00000397606 | PTPRD | chr9 | 8404537 | - | ENST00000381858 | CDC37L1 | chr9 | 4697096 | + | 3567 | 3040 | 33 | 3458 | 1141 |
ENST00000397606 | PTPRD | chr9 | 8404537 | - | ENST00000381854 | CDC37L1 | chr9 | 4697096 | + | 5832 | 3040 | 33 | 3545 | 1170 |
DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated. |
Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
ENST00000360074 | ENST00000381858 | PTPRD | chr9 | 8404537 | - | CDC37L1 | chr9 | 4697096 | + | 0.000407094 | 0.99959296 |
ENST00000360074 | ENST00000381854 | PTPRD | chr9 | 8404537 | - | CDC37L1 | chr9 | 4697096 | + | 0.000132512 | 0.99986744 |
ENST00000537002 | ENST00000381858 | PTPRD | chr9 | 8404537 | - | CDC37L1 | chr9 | 4697096 | + | 0.000397802 | 0.99960226 |
ENST00000537002 | ENST00000381854 | PTPRD | chr9 | 8404537 | - | CDC37L1 | chr9 | 4697096 | + | 0.000119465 | 0.99988055 |
ENST00000397617 | ENST00000381858 | PTPRD | chr9 | 8404537 | - | CDC37L1 | chr9 | 4697096 | + | 0.000368226 | 0.99963176 |
ENST00000397617 | ENST00000381854 | PTPRD | chr9 | 8404537 | - | CDC37L1 | chr9 | 4697096 | + | 0.000123145 | 0.99987686 |
ENST00000358503 | ENST00000381858 | PTPRD | chr9 | 8404537 | - | CDC37L1 | chr9 | 4697096 | + | 0.000366579 | 0.99963343 |
ENST00000358503 | ENST00000381854 | PTPRD | chr9 | 8404537 | - | CDC37L1 | chr9 | 4697096 | + | 0.000178281 | 0.9998217 |
ENST00000397611 | ENST00000381858 | PTPRD | chr9 | 8404537 | - | CDC37L1 | chr9 | 4697096 | + | 0.000383435 | 0.9996165 |
ENST00000397611 | ENST00000381854 | PTPRD | chr9 | 8404537 | - | CDC37L1 | chr9 | 4697096 | + | 0.000125945 | 0.999874 |
ENST00000355233 | ENST00000381858 | PTPRD | chr9 | 8404537 | - | CDC37L1 | chr9 | 4697096 | + | 0.00038274 | 0.9996172 |
ENST00000355233 | ENST00000381854 | PTPRD | chr9 | 8404537 | - | CDC37L1 | chr9 | 4697096 | + | 0.000137385 | 0.99986255 |
ENST00000356435 | ENST00000381858 | PTPRD | chr9 | 8404537 | - | CDC37L1 | chr9 | 4697096 | + | 0.000389432 | 0.9996106 |
ENST00000356435 | ENST00000381854 | PTPRD | chr9 | 8404537 | - | CDC37L1 | chr9 | 4697096 | + | 0.000133452 | 0.9998665 |
ENST00000486161 | ENST00000381858 | PTPRD | chr9 | 8404537 | - | CDC37L1 | chr9 | 4697096 | + | 0.000284085 | 0.99971586 |
ENST00000486161 | ENST00000381854 | PTPRD | chr9 | 8404537 | - | CDC37L1 | chr9 | 4697096 | + | 9.57E-05 | 0.9999043 |
ENST00000397606 | ENST00000381858 | PTPRD | chr9 | 8404537 | - | CDC37L1 | chr9 | 4697096 | + | 0.000288715 | 0.9997112 |
ENST00000397606 | ENST00000381854 | PTPRD | chr9 | 8404537 | - | CDC37L1 | chr9 | 4697096 | + | 0.000115536 | 0.9998845 |
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Fusion Amino Acid Sequences |
For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP >70342_70342_1_PTPRD-CDC37L1_PTPRD_chr9_8404537_ENST00000355233_CDC37L1_chr9_4697096_ENST00000381854_length(amino acids)=1171AA_BP=1003 MLPSCRMVHVARLLLLLLTFFLRTDAETPPRFTRTPVDQTGVSGGVASFICQATGDPRPKIVWNKKGKKVSNQRFEVIEFDDGSGSVLRI QPLRTPRDEAIYECVASNNVGEISVSTRLTVLREDQIPRGFPTIDMGPQLKVVERTRTATMLCAASGNPDPEITWFKDFLPVDTSNNNGR IKQLRSESIGGTPIRGALQIEQSEESDQGKYECVATNSAGTRYSAPANLYVRELREVRRVPPRFSIPPTNHEIMPGGSVNITCVAVGSPM PYVKWMLGAEDLTPEDDMPIGRNVLELNDVRQSANYTCVAMSTLGVIEAIAQITVKALPKPPGTPVVTESTATSITLTWDSGNPEPVSYY IIQHKPKNSEELYKEIDGVATTRYSVAGLSPYSDYEFRVVAVNNIGRGPPSEPVLTQTSEQAPSSAPRDVQARMLSSTTILVQWKEPEEP NGQIQGYRVYYTMDPTQHVNNWMKHNVADSQITTIGNLVPQKTYSVKVLAFTSIGDGPLSSDIQVITQTGVPGQPLNFKAEPESETSILL SWTPPRSDTIANYELVYKDGEHGEEQRITIEPGTSYRLQGLKPNSLYYFRLAARSPQGLGASTAEISARTMQSMFAKNFHVKAVMKTSVL LSWEIPENYNSAMPFKILYDDGKMVEEVDGRATQKLIVNLKPEKSYSFVLTNRGNSAGGLQHRVTAKTAPDVLRTKPAFIGKTNLDGMIT VQLPEVPANENIKGYYIIIVPLKKSRGKFIKPWESPDEMELDELLKEISRKRRSIRYGREVELKPYIAAHFDVLPTEFTLGDDKHYGGFT NKQLQSGQEYVFFVLAVMEHAESKMYATSPYSDPVVSMDLDPQPITDEEEGLIWVVGPVLAVVFIICIVIAILLYKSSKPDRKRAESDSR KSSIPNNKEIPSHHPTDPVELRRLNFQTPGMASHPPIPILELADHIERLKANDNLKFSQEYESIDPGQQFTWEHSNLEVNKPKNRYANVI AYDHSRVLLSAIEGMLSRWDDSQRFLSDHPYLVCEETAKYLILWCFHLEAEKKGALMEQIAHQAVVMQFIMEMAKNCNVDPRGCFRLFFQ KAKAEEEGYFEAFKNELEAFKSRVRLYSQSQSFQPMTVQNHVPHSGVGSIGLLESLPQNPDYLQYSISTALCSLNSVVHKEDDEPKMMDT -------------------------------------------------------------- >70342_70342_2_PTPRD-CDC37L1_PTPRD_chr9_8404537_ENST00000355233_CDC37L1_chr9_4697096_ENST00000381858_length(amino acids)=1142AA_BP=1003 MLPSCRMVHVARLLLLLLTFFLRTDAETPPRFTRTPVDQTGVSGGVASFICQATGDPRPKIVWNKKGKKVSNQRFEVIEFDDGSGSVLRI QPLRTPRDEAIYECVASNNVGEISVSTRLTVLREDQIPRGFPTIDMGPQLKVVERTRTATMLCAASGNPDPEITWFKDFLPVDTSNNNGR IKQLRSESIGGTPIRGALQIEQSEESDQGKYECVATNSAGTRYSAPANLYVRELREVRRVPPRFSIPPTNHEIMPGGSVNITCVAVGSPM PYVKWMLGAEDLTPEDDMPIGRNVLELNDVRQSANYTCVAMSTLGVIEAIAQITVKALPKPPGTPVVTESTATSITLTWDSGNPEPVSYY IIQHKPKNSEELYKEIDGVATTRYSVAGLSPYSDYEFRVVAVNNIGRGPPSEPVLTQTSEQAPSSAPRDVQARMLSSTTILVQWKEPEEP NGQIQGYRVYYTMDPTQHVNNWMKHNVADSQITTIGNLVPQKTYSVKVLAFTSIGDGPLSSDIQVITQTGVPGQPLNFKAEPESETSILL SWTPPRSDTIANYELVYKDGEHGEEQRITIEPGTSYRLQGLKPNSLYYFRLAARSPQGLGASTAEISARTMQSMFAKNFHVKAVMKTSVL LSWEIPENYNSAMPFKILYDDGKMVEEVDGRATQKLIVNLKPEKSYSFVLTNRGNSAGGLQHRVTAKTAPDVLRTKPAFIGKTNLDGMIT VQLPEVPANENIKGYYIIIVPLKKSRGKFIKPWESPDEMELDELLKEISRKRRSIRYGREVELKPYIAAHFDVLPTEFTLGDDKHYGGFT NKQLQSGQEYVFFVLAVMEHAESKMYATSPYSDPVVSMDLDPQPITDEEEGLIWVVGPVLAVVFIICIVIAILLYKSSKPDRKRAESDSR KSSIPNNKEIPSHHPTDPVELRRLNFQTPGMASHPPIPILELADHIERLKANDNLKFSQEYESIDPGQQFTWEHSNLEVNKPKNRYANVI AYDHSRVLLSAIEGMLSRWDDSQRFLSDHPYLVCEETAKYLILWCFHLEAEKKGALMEQIAHQAVVMQFIMEMAKNCNVDPRGCFRLFFQ -------------------------------------------------------------- >70342_70342_3_PTPRD-CDC37L1_PTPRD_chr9_8404537_ENST00000356435_CDC37L1_chr9_4697096_ENST00000381854_length(amino acids)=1577AA_BP=1409 MLPSCRMVHVARLLLLLLTFFLRTDAETPPRFTRTPVDQTGVSGGVASFICQATGDPRPKIVWNKKGKKVSNQRFEVIEFDDGSGSVLRI QPLRTPRDEAIYECVASNNVGEISVSTRLTVLREDQIPRGFPTIDMGPQLKVVERTRTATMLCAASGNPDPEITWFKDFLPVDTSNNNGR IKQLRSESIGGTPIRGALQIEQSEESDQGKYECVATNSAGTRYSAPANLYVRELREVRRVPPRFSIPPTNHEIMPGGSVNITCVAVGSPM PYVKWMLGAEDLTPEDDMPIGRNVLELNDVRQSANYTCVAMSTLGVIEAIAQITVKALPKPPGTPVVTESTATSITLTWDSGNPEPVSYY IIQHKPKNSEELYKEIDGVATTRYSVAGLSPYSDYEFRVVAVNNIGRGPPSEPVLTQTSEQAPSSAPRDVQARMLSSTTILVQWKEPEEP NGQIQGYRVYYTMDPTQHVNNWMKHNVADSQITTIGNLVPQKTYSVKVLAFTSIGDGPLSSDIQVITQTGVPGQPLNFKAEPESETSILL SWTPPRSDTIANYELVYKDGEHGEEQRITIEPGTSYRLQGLKPNSLYYFRLAARSPQGLGASTAEISARTMQSKPSAPPQDISCTSPSST SILVSWQPPPVEKQNGIITEYSIKYTAVDGEDDKPHEILGIPSDTTKYLLEQLEKWTEYRITVTAHTDVGPGPESLSVLIRTNEDVPSGP PRKVEVEAVNSTSVKVSWRSPVPNKQHGQIRGYQVHYVRMENGEPKGQPMLKDVMLADAQWEFDDTTEHDMIISGLQPETSYSLTVTAYT TKGDGARSKPKLVSTTGAVPGKPRLVINHTQMNTALIQWHPPVDTFGPLQGYRLKFGRKDMEPLTTLEFSEKEDHFTATDIHKGASYVFR LSARNKVGFGEEMVKEISIPEEVPTGFPQNLHSEGTTSTSVQLSWQPPVLAERNGIITKYTLLYRDINIPLLPMEQLIVPADTTMTLTGL KPDTTYDVKVRAHTSKGPGPYSPSVQFRTLPVDQVFAKNFHVKAVMKTSVLLSWEIPENYNSAMPFKILYDDGKMVEEVDGRATQKLIVN LKPEKSYSFVLTNRGNSAGGLQHRVTAKTAPDVLRTKPAFIGKTNLDGMITVQLPEVPANENIKGYYIIIVPLKKSRGKFIKPWESPDEM ELDELLKEISRKRRSIRYGREVELKPYIAAHFDVLPTEFTLGDDKHYGGFTNKQLQSGQEYVFFVLAVMEHAESKMYATSPYSDPVVSMD LDPQPITDEEEGLIWVVGPVLAVVFIICIVIAILLYKRKRAESDSRKSSIPNNKEIPSHHPTDPVELRRLNFQTPGMASHPPIPILELAD HIERLKANDNLKFSQEYESIDPGQQFTWEHSNLEVNKPKNRYANVIAYDHSRVLLSAIEGMLSRWDDSQRFLSDHPYLVCEETAKYLILW CFHLEAEKKGALMEQIAHQAVVMQFIMEMAKNCNVDPRGCFRLFFQKAKAEEEGYFEAFKNELEAFKSRVRLYSQSQSFQPMTVQNHVPH -------------------------------------------------------------- >70342_70342_4_PTPRD-CDC37L1_PTPRD_chr9_8404537_ENST00000356435_CDC37L1_chr9_4697096_ENST00000381858_length(amino acids)=1548AA_BP=1409 MLPSCRMVHVARLLLLLLTFFLRTDAETPPRFTRTPVDQTGVSGGVASFICQATGDPRPKIVWNKKGKKVSNQRFEVIEFDDGSGSVLRI QPLRTPRDEAIYECVASNNVGEISVSTRLTVLREDQIPRGFPTIDMGPQLKVVERTRTATMLCAASGNPDPEITWFKDFLPVDTSNNNGR IKQLRSESIGGTPIRGALQIEQSEESDQGKYECVATNSAGTRYSAPANLYVRELREVRRVPPRFSIPPTNHEIMPGGSVNITCVAVGSPM PYVKWMLGAEDLTPEDDMPIGRNVLELNDVRQSANYTCVAMSTLGVIEAIAQITVKALPKPPGTPVVTESTATSITLTWDSGNPEPVSYY IIQHKPKNSEELYKEIDGVATTRYSVAGLSPYSDYEFRVVAVNNIGRGPPSEPVLTQTSEQAPSSAPRDVQARMLSSTTILVQWKEPEEP NGQIQGYRVYYTMDPTQHVNNWMKHNVADSQITTIGNLVPQKTYSVKVLAFTSIGDGPLSSDIQVITQTGVPGQPLNFKAEPESETSILL SWTPPRSDTIANYELVYKDGEHGEEQRITIEPGTSYRLQGLKPNSLYYFRLAARSPQGLGASTAEISARTMQSKPSAPPQDISCTSPSST SILVSWQPPPVEKQNGIITEYSIKYTAVDGEDDKPHEILGIPSDTTKYLLEQLEKWTEYRITVTAHTDVGPGPESLSVLIRTNEDVPSGP PRKVEVEAVNSTSVKVSWRSPVPNKQHGQIRGYQVHYVRMENGEPKGQPMLKDVMLADAQWEFDDTTEHDMIISGLQPETSYSLTVTAYT TKGDGARSKPKLVSTTGAVPGKPRLVINHTQMNTALIQWHPPVDTFGPLQGYRLKFGRKDMEPLTTLEFSEKEDHFTATDIHKGASYVFR LSARNKVGFGEEMVKEISIPEEVPTGFPQNLHSEGTTSTSVQLSWQPPVLAERNGIITKYTLLYRDINIPLLPMEQLIVPADTTMTLTGL KPDTTYDVKVRAHTSKGPGPYSPSVQFRTLPVDQVFAKNFHVKAVMKTSVLLSWEIPENYNSAMPFKILYDDGKMVEEVDGRATQKLIVN LKPEKSYSFVLTNRGNSAGGLQHRVTAKTAPDVLRTKPAFIGKTNLDGMITVQLPEVPANENIKGYYIIIVPLKKSRGKFIKPWESPDEM ELDELLKEISRKRRSIRYGREVELKPYIAAHFDVLPTEFTLGDDKHYGGFTNKQLQSGQEYVFFVLAVMEHAESKMYATSPYSDPVVSMD LDPQPITDEEEGLIWVVGPVLAVVFIICIVIAILLYKRKRAESDSRKSSIPNNKEIPSHHPTDPVELRRLNFQTPGMASHPPIPILELAD HIERLKANDNLKFSQEYESIDPGQQFTWEHSNLEVNKPKNRYANVIAYDHSRVLLSAIEGMLSRWDDSQRFLSDHPYLVCEETAKYLILW CFHLEAEKKGALMEQIAHQAVVMQFIMEMAKNCNVDPRGCFRLFFQKAKAEEEGYFEAFKNELEAFKSRVRLYSQSQSFQPMTVQNHVPH -------------------------------------------------------------- >70342_70342_5_PTPRD-CDC37L1_PTPRD_chr9_8404537_ENST00000358503_CDC37L1_chr9_4697096_ENST00000381854_length(amino acids)=1555AA_BP=1387 MLPSCRMVHVARLLLLLLTFFLRTDAETPPRFTRTPVDQTGVSGGVASFICQATGDPRPKIVWNKKGKKVSNQRFEVIEFDDGSGSVLRI QPLRTPRDEAIYECVASNNVGEISVSTRLTVLREDQIPRGFPTIDMGPQLKVVERTRTATMLCAASGNPDPEITWFKDFLPVDTSNNNGR IKQLRSGALQIEQSEESDQGKYECVATNSAGTRYSAPANLYVRVRRVPPRFSIPPTNHEIMPGGSVNITCVAVGSPMPYVKWMLGAEDLT PEDDMPIGRNVLELNDVRQSANYTCVAMSTLGVIEAIAQITVKALPKPPGTPVVTESTATSITLTWDSGNPEPVSYYIIQHKPKNSEELY KEIDGVATTRYSVAGLSPYSDYEFRVVAVNNIGRGPPSEPVLTQTSEQAPSSAPRDVQARMLSSTTILVQWKEPEEPNGQIQGYRVYYTM DPTQHVNNWMKHNVADSQITTIGNLVPQKTYSVKVLAFTSIGDGPLSSDIQVITQTGVPGQPLNFKAEPESETSILLSWTPPRSDTIANY ELVYKDGEHGEEQRITIEPGTSYRLQGLKPNSLYYFRLAARSPQGLGASTAEISARTMQSKPSAPPQDISCTSPSSTSILVSWQPPPVEK QNGIITEYSIKYTAVDGEDDKPHEILGIPSDTTKYLLEQLEKWTEYRITVTAHTDVGPGPESLSVLIRTNEDVPSGPPRKVEVEAVNSTS VKVSWRSPVPNKQHGQIRGYQVHYVRMENGEPKGQPMLKDVMLADAQDMIISGLQPETSYSLTVTAYTTKGDGARSKPKLVSTTGAVPGK PRLVINHTQMNTALIQWHPPVDTFGPLQGYRLKFGRKDMEPLTTLEFSEKEDHFTATDIHKGASYVFRLSARNKVGFGEEMVKEISIPEE VPTGFPQNLHSEGTTSTSVQLSWQPPVLAERNGIITKYTLLYRDINIPLLPMEQLIVPADTTMTLTGLKPDTTYDVKVRAHTSKGPGPYS PSVQFRTLPVDQVFAKNFHVKAVMKTSVLLSWEIPENYNSAMPFKILYDDGKMVEEVDGRATQKLIVNLKPEKSYSFVLTNRGNSAGGLQ HRVTAKTAPDVLRTKPAFIGKTNLDGMITVQLPEVPANENIKGYYIIIVPLKKSRGKFIKPWESPDEMELDELLKEISRKRRSIRYGREV ELKPYIAAHFDVLPTEFTLGDDKHYGGFTNKQLQSGQEYVFFVLAVMEHAESKMYATSPYSDPVVSMDLDPQPITDEEEGLIWVVGPVLA VVFIICIVIAILLYKRKRAESDSRKSSIPNNKEIPSHHPTDPVELRRLNFQTPGMASHPPIPILELADHIERLKANDNLKFSQEYESIDP GQQFTWEHSNLEVNKPKNRYANVIAYDHSRVLLSAIEGMLSRWDDSQRFLSDHPYLVCEETAKYLILWCFHLEAEKKGALMEQIAHQAVV MQFIMEMAKNCNVDPRGCFRLFFQKAKAEEEGYFEAFKNELEAFKSRVRLYSQSQSFQPMTVQNHVPHSGVGSIGLLESLPQNPDYLQYS -------------------------------------------------------------- >70342_70342_6_PTPRD-CDC37L1_PTPRD_chr9_8404537_ENST00000358503_CDC37L1_chr9_4697096_ENST00000381858_length(amino acids)=1526AA_BP=1387 MLPSCRMVHVARLLLLLLTFFLRTDAETPPRFTRTPVDQTGVSGGVASFICQATGDPRPKIVWNKKGKKVSNQRFEVIEFDDGSGSVLRI QPLRTPRDEAIYECVASNNVGEISVSTRLTVLREDQIPRGFPTIDMGPQLKVVERTRTATMLCAASGNPDPEITWFKDFLPVDTSNNNGR IKQLRSGALQIEQSEESDQGKYECVATNSAGTRYSAPANLYVRVRRVPPRFSIPPTNHEIMPGGSVNITCVAVGSPMPYVKWMLGAEDLT PEDDMPIGRNVLELNDVRQSANYTCVAMSTLGVIEAIAQITVKALPKPPGTPVVTESTATSITLTWDSGNPEPVSYYIIQHKPKNSEELY KEIDGVATTRYSVAGLSPYSDYEFRVVAVNNIGRGPPSEPVLTQTSEQAPSSAPRDVQARMLSSTTILVQWKEPEEPNGQIQGYRVYYTM DPTQHVNNWMKHNVADSQITTIGNLVPQKTYSVKVLAFTSIGDGPLSSDIQVITQTGVPGQPLNFKAEPESETSILLSWTPPRSDTIANY ELVYKDGEHGEEQRITIEPGTSYRLQGLKPNSLYYFRLAARSPQGLGASTAEISARTMQSKPSAPPQDISCTSPSSTSILVSWQPPPVEK QNGIITEYSIKYTAVDGEDDKPHEILGIPSDTTKYLLEQLEKWTEYRITVTAHTDVGPGPESLSVLIRTNEDVPSGPPRKVEVEAVNSTS VKVSWRSPVPNKQHGQIRGYQVHYVRMENGEPKGQPMLKDVMLADAQDMIISGLQPETSYSLTVTAYTTKGDGARSKPKLVSTTGAVPGK PRLVINHTQMNTALIQWHPPVDTFGPLQGYRLKFGRKDMEPLTTLEFSEKEDHFTATDIHKGASYVFRLSARNKVGFGEEMVKEISIPEE VPTGFPQNLHSEGTTSTSVQLSWQPPVLAERNGIITKYTLLYRDINIPLLPMEQLIVPADTTMTLTGLKPDTTYDVKVRAHTSKGPGPYS PSVQFRTLPVDQVFAKNFHVKAVMKTSVLLSWEIPENYNSAMPFKILYDDGKMVEEVDGRATQKLIVNLKPEKSYSFVLTNRGNSAGGLQ HRVTAKTAPDVLRTKPAFIGKTNLDGMITVQLPEVPANENIKGYYIIIVPLKKSRGKFIKPWESPDEMELDELLKEISRKRRSIRYGREV ELKPYIAAHFDVLPTEFTLGDDKHYGGFTNKQLQSGQEYVFFVLAVMEHAESKMYATSPYSDPVVSMDLDPQPITDEEEGLIWVVGPVLA VVFIICIVIAILLYKRKRAESDSRKSSIPNNKEIPSHHPTDPVELRRLNFQTPGMASHPPIPILELADHIERLKANDNLKFSQEYESIDP GQQFTWEHSNLEVNKPKNRYANVIAYDHSRVLLSAIEGMLSRWDDSQRFLSDHPYLVCEETAKYLILWCFHLEAEKKGALMEQIAHQAVV -------------------------------------------------------------- >70342_70342_7_PTPRD-CDC37L1_PTPRD_chr9_8404537_ENST00000360074_CDC37L1_chr9_4697096_ENST00000381854_length(amino acids)=1564AA_BP=1396 MLPSCRMVHVARLLLLLLTFFLRTDAETPPRFTRTPVDQTGVSGGVASFICQATGDPRPKIVWNKKGKKVSNQRFEVIEFDDGSGSVLRI QPLRTPRDEAIYECVASNNVGEISVSTRLTVLREDQIPRGFPTIDMGPQLKVVERTRTATMLCAASGNPDPEITWFKDFLPVDTSNNNGR IKQLRSGALQIEQSEESDQGKYECVATNSAGTRYSAPANLYVRVRRVPPRFSIPPTNHEIMPGGSVNITCVAVGSPMPYVKWMLGAEDLT PEDDMPIGRNVLELNDVRQSANYTCVAMSTLGVIEAIAQITVKALPKPPGTPVVTESTATSITLTWDSGNPEPVSYYIIQHKPKNSEELY KEIDGVATTRYSVAGLSPYSDYEFRVVAVNNIGRGPPSEPVLTQTSEQAPSSAPRDVQARMLSSTTILVQWKEPEEPNGQIQGYRVYYTM DPTQHVNNWMKHNVADSQITTIGNLVPQKTYSVKVLAFTSIGDGPLSSDIQVITQTGVPGQPLNFKAEPESETSILLSWTPPRSDTIANY ELVYKDGEHGEEQRITIEPGTSYRLQGLKPNSLYYFRLAARSPQGLGASTAEISARTMQSKPSAPPQDISCTSPSSTSILVSWQPPPVEK QNGIITEYSIKYTAVDGEDDKPHEILGIPSDTTKYLLEQLEKWTEYRITVTAHTDVGPGPESLSVLIRTNEDVPSGPPRKVEVEAVNSTS VKVSWRSPVPNKQHGQIRGYQVHYVRMENGEPKGQPMLKDVMLADAQWEFDDTTEHDMIISGLQPETSYSLTVTAYTTKGDGARSKPKLV STTGAVPGKPRLVINHTQMNTALIQWHPPVDTFGPLQGYRLKFGRKDMEPLTTLEFSEKEDHFTATDIHKGASYVFRLSARNKVGFGEEM VKEISIPEEVPTGFPQNLHSEGTTSTSVQLSWQPPVLAERNGIITKYTLLYRDINIPLLPMEQLIVPADTTMTLTGLKPDTTYDVKVRAH TSKGPGPYSPSVQFRTLPVDQVFAKNFHVKAVMKTSVLLSWEIPENYNSAMPFKILYDDGKMVEEVDGRATQKLIVNLKPEKSYSFVLTN RGNSAGGLQHRVTAKTAPDVLRTKPAFIGKTNLDGMITVQLPEVPANENIKGYYIIIVPLKKSRGKFIKPWESPDEMELDELLKEISRKR RSIRYGREVELKPYIAAHFDVLPTEFTLGDDKHYGGFTNKQLQSGQEYVFFVLAVMEHAESKMYATSPYSDPVVSMDLDPQPITDEEEGL IWVVGPVLAVVFIICIVIAILLYKRKRAESDSRKSSIPNNKEIPSHHPTDPVELRRLNFQTPGMASHPPIPILELADHIERLKANDNLKF SQEYESIDPGQQFTWEHSNLEVNKPKNRYANVIAYDHSRVLLSAIEGMLSRWDDSQRFLSDHPYLVCEETAKYLILWCFHLEAEKKGALM EQIAHQAVVMQFIMEMAKNCNVDPRGCFRLFFQKAKAEEEGYFEAFKNELEAFKSRVRLYSQSQSFQPMTVQNHVPHSGVGSIGLLESLP -------------------------------------------------------------- >70342_70342_8_PTPRD-CDC37L1_PTPRD_chr9_8404537_ENST00000360074_CDC37L1_chr9_4697096_ENST00000381858_length(amino acids)=1535AA_BP=1396 MLPSCRMVHVARLLLLLLTFFLRTDAETPPRFTRTPVDQTGVSGGVASFICQATGDPRPKIVWNKKGKKVSNQRFEVIEFDDGSGSVLRI QPLRTPRDEAIYECVASNNVGEISVSTRLTVLREDQIPRGFPTIDMGPQLKVVERTRTATMLCAASGNPDPEITWFKDFLPVDTSNNNGR IKQLRSGALQIEQSEESDQGKYECVATNSAGTRYSAPANLYVRVRRVPPRFSIPPTNHEIMPGGSVNITCVAVGSPMPYVKWMLGAEDLT PEDDMPIGRNVLELNDVRQSANYTCVAMSTLGVIEAIAQITVKALPKPPGTPVVTESTATSITLTWDSGNPEPVSYYIIQHKPKNSEELY KEIDGVATTRYSVAGLSPYSDYEFRVVAVNNIGRGPPSEPVLTQTSEQAPSSAPRDVQARMLSSTTILVQWKEPEEPNGQIQGYRVYYTM DPTQHVNNWMKHNVADSQITTIGNLVPQKTYSVKVLAFTSIGDGPLSSDIQVITQTGVPGQPLNFKAEPESETSILLSWTPPRSDTIANY ELVYKDGEHGEEQRITIEPGTSYRLQGLKPNSLYYFRLAARSPQGLGASTAEISARTMQSKPSAPPQDISCTSPSSTSILVSWQPPPVEK QNGIITEYSIKYTAVDGEDDKPHEILGIPSDTTKYLLEQLEKWTEYRITVTAHTDVGPGPESLSVLIRTNEDVPSGPPRKVEVEAVNSTS VKVSWRSPVPNKQHGQIRGYQVHYVRMENGEPKGQPMLKDVMLADAQWEFDDTTEHDMIISGLQPETSYSLTVTAYTTKGDGARSKPKLV STTGAVPGKPRLVINHTQMNTALIQWHPPVDTFGPLQGYRLKFGRKDMEPLTTLEFSEKEDHFTATDIHKGASYVFRLSARNKVGFGEEM VKEISIPEEVPTGFPQNLHSEGTTSTSVQLSWQPPVLAERNGIITKYTLLYRDINIPLLPMEQLIVPADTTMTLTGLKPDTTYDVKVRAH TSKGPGPYSPSVQFRTLPVDQVFAKNFHVKAVMKTSVLLSWEIPENYNSAMPFKILYDDGKMVEEVDGRATQKLIVNLKPEKSYSFVLTN RGNSAGGLQHRVTAKTAPDVLRTKPAFIGKTNLDGMITVQLPEVPANENIKGYYIIIVPLKKSRGKFIKPWESPDEMELDELLKEISRKR RSIRYGREVELKPYIAAHFDVLPTEFTLGDDKHYGGFTNKQLQSGQEYVFFVLAVMEHAESKMYATSPYSDPVVSMDLDPQPITDEEEGL IWVVGPVLAVVFIICIVIAILLYKRKRAESDSRKSSIPNNKEIPSHHPTDPVELRRLNFQTPGMASHPPIPILELADHIERLKANDNLKF SQEYESIDPGQQFTWEHSNLEVNKPKNRYANVIAYDHSRVLLSAIEGMLSRWDDSQRFLSDHPYLVCEETAKYLILWCFHLEAEKKGALM EQIAHQAVVMQFIMEMAKNCNVDPRGCFRLFFQKAKAEEEGYFEAFKNELEAFKSRVRLYSQSQSFQPMTVQNHVPHSGVGSIGLLESLP -------------------------------------------------------------- >70342_70342_9_PTPRD-CDC37L1_PTPRD_chr9_8404537_ENST00000397606_CDC37L1_chr9_4697096_ENST00000381854_length(amino acids)=1170AA_BP=1002 MLPSCRMVHVARLLLLLLTFFLRTDAETPPRFTRTPVDQTGVSGGVASFICQATGDPRPKIVWNKKGKKVSNQRFEVIEFDDGSGSVLRI QPLRTPRDEAIYECVASNNVGEISVSTRLTVLREDQIPRGFPTIDMGPQLKVVERTRTATMLCAASGNPDPEITWFKDFLPVDTSNNNGR IKQLRSESIGALQIEQSEESDQGKYECVATNSAGTRYSAPANLYVRVRRVPPRFSIPPTNHEIMPGGSVNITCVAVGSPMPYVKWMLGAE DLTPEDDMPIGRNVLELNDVRQSANYTCVAMSTLGVIEAIAQITVKALPKPPGTPVVTESTATSITLTWDSGNPEPVSYYIIQHKPKNSE ELYKEIDGVATTRYSVAGLSPYSDYEFRVVAVNNIGRGPPSEPVLTQTSEQAPSSAPRDVQARMLSSTTILVQWKEPEEPNGQIQGYRVY YTMDPTQHVNNWMKHNVADSQITTIGNLVPQKTYSVKVLAFTSIGDGPLSSDIQVITQTGVPGQPLNFKAEPESETSILLSWTPPRSDTI ANYELVYKDGEHGEEQRITIEPGTSYRLQGLKPNSLYYFRLAARSPQGLGASTAEISARTMQSMFAKNFHVKAVMKTSVLLSWEIPENYN SAMPFKILYDDGKMVEEVDGRATQKLIVNLKPEKSYSFVLTNRGNSAGGLQHRVTAKTAPDVLRTKPAFIGKTNLDGMITVQLPEVPANE NIKGYYIIIVPLKKSRGKFIKPWESPDEMELDELLKEISRKRRSIRYGREVELKPYIAAHFDVLPTEFTLGDDKHYGGFTNKQLQSGQEY VFFVLAVMEHAESKMYATSPYSDPVVSMDLDPQPITDEEEGLIWVVGPVLAVVFIICIVIAILLYKRKRAESDSRKSSIPNNKEIPSHHP TDPVELRRLNFQTPGSDDSGYPGNLHSSSMASHPPIPILELADHIERLKANDNLKFSQEYESIDPGQQFTWEHSNLEVNKPKNRYANVIA YDHSRVLLSAIEGMLSRWDDSQRFLSDHPYLVCEETAKYLILWCFHLEAEKKGALMEQIAHQAVVMQFIMEMAKNCNVDPRGCFRLFFQK AKAEEEGYFEAFKNELEAFKSRVRLYSQSQSFQPMTVQNHVPHSGVGSIGLLESLPQNPDYLQYSISTALCSLNSVVHKEDDEPKMMDTV -------------------------------------------------------------- >70342_70342_10_PTPRD-CDC37L1_PTPRD_chr9_8404537_ENST00000397606_CDC37L1_chr9_4697096_ENST00000381858_length(amino acids)=1141AA_BP=1002 MLPSCRMVHVARLLLLLLTFFLRTDAETPPRFTRTPVDQTGVSGGVASFICQATGDPRPKIVWNKKGKKVSNQRFEVIEFDDGSGSVLRI QPLRTPRDEAIYECVASNNVGEISVSTRLTVLREDQIPRGFPTIDMGPQLKVVERTRTATMLCAASGNPDPEITWFKDFLPVDTSNNNGR IKQLRSESIGALQIEQSEESDQGKYECVATNSAGTRYSAPANLYVRVRRVPPRFSIPPTNHEIMPGGSVNITCVAVGSPMPYVKWMLGAE DLTPEDDMPIGRNVLELNDVRQSANYTCVAMSTLGVIEAIAQITVKALPKPPGTPVVTESTATSITLTWDSGNPEPVSYYIIQHKPKNSE ELYKEIDGVATTRYSVAGLSPYSDYEFRVVAVNNIGRGPPSEPVLTQTSEQAPSSAPRDVQARMLSSTTILVQWKEPEEPNGQIQGYRVY YTMDPTQHVNNWMKHNVADSQITTIGNLVPQKTYSVKVLAFTSIGDGPLSSDIQVITQTGVPGQPLNFKAEPESETSILLSWTPPRSDTI ANYELVYKDGEHGEEQRITIEPGTSYRLQGLKPNSLYYFRLAARSPQGLGASTAEISARTMQSMFAKNFHVKAVMKTSVLLSWEIPENYN SAMPFKILYDDGKMVEEVDGRATQKLIVNLKPEKSYSFVLTNRGNSAGGLQHRVTAKTAPDVLRTKPAFIGKTNLDGMITVQLPEVPANE NIKGYYIIIVPLKKSRGKFIKPWESPDEMELDELLKEISRKRRSIRYGREVELKPYIAAHFDVLPTEFTLGDDKHYGGFTNKQLQSGQEY VFFVLAVMEHAESKMYATSPYSDPVVSMDLDPQPITDEEEGLIWVVGPVLAVVFIICIVIAILLYKRKRAESDSRKSSIPNNKEIPSHHP TDPVELRRLNFQTPGSDDSGYPGNLHSSSMASHPPIPILELADHIERLKANDNLKFSQEYESIDPGQQFTWEHSNLEVNKPKNRYANVIA YDHSRVLLSAIEGMLSRWDDSQRFLSDHPYLVCEETAKYLILWCFHLEAEKKGALMEQIAHQAVVMQFIMEMAKNCNVDPRGCFRLFFQK -------------------------------------------------------------- >70342_70342_11_PTPRD-CDC37L1_PTPRD_chr9_8404537_ENST00000397611_CDC37L1_chr9_4697096_ENST00000381854_length(amino acids)=1167AA_BP=999 MLPSCRMVHVARLLLLLLTFFLRTDAETPPRFTRTPVDQTGVSGGVASFICQATGDPRPKIVWNKKGKKVSNQRFEVIEFDDGSGSVLRI QPLRTPRDEAIYECVASNNVGEISVSTRLTVLREDQIPRGFPTIDMGPQLKVVERTRTATMLCAASGNPDPEITWFKDFLPVDTSNNNGR IKQLRSGGTPIRGALQIEQSEESDQGKYECVATNSAGTRYSAPANLYVRELREVRRVPPRFSIPPTNHEIMPGGSVNITCVAVGSPMPYV KWMLGAEDLTPEDDMPIGRNVLELNDVRQSANYTCVAMSTLGVIEAIAQITVKALPKPPGTPVVTESTATSITLTWDSGNPEPVSYYIIQ HKPKNSEELYKEIDGVATTRYSVAGLSPYSDYEFRVVAVNNIGRGPPSEPVLTQTSEQAPSSAPRDVQARMLSSTTILVQWKEPEEPNGQ IQGYRVYYTMDPTQHVNNWMKHNVADSQITTIGNLVPQKTYSVKVLAFTSIGDGPLSSDIQVITQTGVPGQPLNFKAEPESETSILLSWT PPRSDTIANYELVYKDGEHGEEQRITIEPGTSYRLQGLKPNSLYYFRLAARSPQGLGASTAEISARTMQSMFAKNFHVKAVMKTSVLLSW EIPENYNSAMPFKILYDDGKMVEEVDGRATQKLIVNLKPEKSYSFVLTNRGNSAGGLQHRVTAKTAPDVLRTKPAFIGKTNLDGMITVQL PEVPANENIKGYYIIIVPLKKSRGKFIKPWESPDEMELDELLKEISRKRRSIRYGREVELKPYIAAHFDVLPTEFTLGDDKHYGGFTNKQ LQSGQEYVFFVLAVMEHAESKMYATSPYSDPVVSMDLDPQPITDEEEGLIWVVGPVLAVVFIICIVIAILLYKSKPDRKRAESDSRKSSI PNNKEIPSHHPTDPVELRRLNFQTPGMASHPPIPILELADHIERLKANDNLKFSQEYESIDPGQQFTWEHSNLEVNKPKNRYANVIAYDH SRVLLSAIEGMLSRWDDSQRFLSDHPYLVCEETAKYLILWCFHLEAEKKGALMEQIAHQAVVMQFIMEMAKNCNVDPRGCFRLFFQKAKA -------------------------------------------------------------- >70342_70342_12_PTPRD-CDC37L1_PTPRD_chr9_8404537_ENST00000397611_CDC37L1_chr9_4697096_ENST00000381858_length(amino acids)=1138AA_BP=999 MLPSCRMVHVARLLLLLLTFFLRTDAETPPRFTRTPVDQTGVSGGVASFICQATGDPRPKIVWNKKGKKVSNQRFEVIEFDDGSGSVLRI QPLRTPRDEAIYECVASNNVGEISVSTRLTVLREDQIPRGFPTIDMGPQLKVVERTRTATMLCAASGNPDPEITWFKDFLPVDTSNNNGR IKQLRSGGTPIRGALQIEQSEESDQGKYECVATNSAGTRYSAPANLYVRELREVRRVPPRFSIPPTNHEIMPGGSVNITCVAVGSPMPYV KWMLGAEDLTPEDDMPIGRNVLELNDVRQSANYTCVAMSTLGVIEAIAQITVKALPKPPGTPVVTESTATSITLTWDSGNPEPVSYYIIQ HKPKNSEELYKEIDGVATTRYSVAGLSPYSDYEFRVVAVNNIGRGPPSEPVLTQTSEQAPSSAPRDVQARMLSSTTILVQWKEPEEPNGQ IQGYRVYYTMDPTQHVNNWMKHNVADSQITTIGNLVPQKTYSVKVLAFTSIGDGPLSSDIQVITQTGVPGQPLNFKAEPESETSILLSWT PPRSDTIANYELVYKDGEHGEEQRITIEPGTSYRLQGLKPNSLYYFRLAARSPQGLGASTAEISARTMQSMFAKNFHVKAVMKTSVLLSW EIPENYNSAMPFKILYDDGKMVEEVDGRATQKLIVNLKPEKSYSFVLTNRGNSAGGLQHRVTAKTAPDVLRTKPAFIGKTNLDGMITVQL PEVPANENIKGYYIIIVPLKKSRGKFIKPWESPDEMELDELLKEISRKRRSIRYGREVELKPYIAAHFDVLPTEFTLGDDKHYGGFTNKQ LQSGQEYVFFVLAVMEHAESKMYATSPYSDPVVSMDLDPQPITDEEEGLIWVVGPVLAVVFIICIVIAILLYKSKPDRKRAESDSRKSSI PNNKEIPSHHPTDPVELRRLNFQTPGMASHPPIPILELADHIERLKANDNLKFSQEYESIDPGQQFTWEHSNLEVNKPKNRYANVIAYDH SRVLLSAIEGMLSRWDDSQRFLSDHPYLVCEETAKYLILWCFHLEAEKKGALMEQIAHQAVVMQFIMEMAKNCNVDPRGCFRLFFQKAKA -------------------------------------------------------------- >70342_70342_13_PTPRD-CDC37L1_PTPRD_chr9_8404537_ENST00000397617_CDC37L1_chr9_4697096_ENST00000381854_length(amino acids)=1170AA_BP=1002 MLPSCRMVHVARLLLLLLTFFLRTDAETPPRFTRTPVDQTGVSGGVASFICQATGDPRPKIVWNKKGKKVSNQRFEVIEFDDGSGSVLRI QPLRTPRDEAIYECVASNNVGEISVSTRLTVLREDQIPRGFPTIDMGPQLKVVERTRTATMLCAASGNPDPEITWFKDFLPVDTSNNNGR IKQLRSVSIGALQIEQSEESDQGKYECVATNSAGTRYSAPANLYVRVRRVPPRFSIPPTNHEIMPGGSVNITCVAVGSPMPYVKWMLGAE DLTPEDDMPIGRNVLELNDVRQSANYTCVAMSTLGVIEAIAQITVKALPKPPGTPVVTESTATSITLTWDSGNPEPVSYYIIQHKPKNSE ELYKEIDGVATTRYSVAGLSPYSDYEFRVVAVNNIGRGPPSEPVLTQTSEQAPSSAPRDVQARMLSSTTILVQWKEPEEPNGQIQGYRVY YTMDPTQHVNNWMKHNVADSQITTIGNLVPQKTYSVKVLAFTSIGDGPLSSDIQVITQTGVPGQPLNFKAEPESETSILLSWTPPRSDTI ANYELVYKDGEHGEEQRITIEPGTSYRLQGLKPNSLYYFRLAARSPQGLGASTAEISARTMQSMFAKNFHVKAVMKTSVLLSWEIPENYN SAMPFKILYDDGKMVEEVDGRATQKLIVNLKPEKSYSFVLTNRGNSAGGLQHRVTAKTAPDVLRTKPAFIGKTNLDGMITVQLPEVPANE NIKGYYIIIVPLKKSRGKFIKPWESPDEMELDELLKEISRKRRSIRYGREVELKPYIAAHFDVLPTEFTLGDDKHYGGFTNKQLQSGQEY VFFVLAVMEHAESKMYATSPYSDPVVSMDLDPQPITDEEEGLIWVVGPVLAVVFIICIVIAILLYKRKRAESDSRKSSIPNNKEIPSHHP TDPVELRRLNFQTPGSDDSGYPGNLHSSSMASHPPIPILELADHIERLKANDNLKFSQEYESIDPGQQFTWEHSNLEVNKPKNRYANVIA YDHSRVLLSAIEGMLSRWDDSQRFLSDHPYLVCEETAKYLILWCFHLEAEKKGALMEQIAHQAVVMQFIMEMAKNCNVDPRGCFRLFFQK AKAEEEGYFEAFKNELEAFKSRVRLYSQSQSFQPMTVQNHVPHSGVGSIGLLESLPQNPDYLQYSISTALCSLNSVVHKEDDEPKMMDTV -------------------------------------------------------------- >70342_70342_14_PTPRD-CDC37L1_PTPRD_chr9_8404537_ENST00000397617_CDC37L1_chr9_4697096_ENST00000381858_length(amino acids)=1141AA_BP=1002 MLPSCRMVHVARLLLLLLTFFLRTDAETPPRFTRTPVDQTGVSGGVASFICQATGDPRPKIVWNKKGKKVSNQRFEVIEFDDGSGSVLRI QPLRTPRDEAIYECVASNNVGEISVSTRLTVLREDQIPRGFPTIDMGPQLKVVERTRTATMLCAASGNPDPEITWFKDFLPVDTSNNNGR IKQLRSVSIGALQIEQSEESDQGKYECVATNSAGTRYSAPANLYVRVRRVPPRFSIPPTNHEIMPGGSVNITCVAVGSPMPYVKWMLGAE DLTPEDDMPIGRNVLELNDVRQSANYTCVAMSTLGVIEAIAQITVKALPKPPGTPVVTESTATSITLTWDSGNPEPVSYYIIQHKPKNSE ELYKEIDGVATTRYSVAGLSPYSDYEFRVVAVNNIGRGPPSEPVLTQTSEQAPSSAPRDVQARMLSSTTILVQWKEPEEPNGQIQGYRVY YTMDPTQHVNNWMKHNVADSQITTIGNLVPQKTYSVKVLAFTSIGDGPLSSDIQVITQTGVPGQPLNFKAEPESETSILLSWTPPRSDTI ANYELVYKDGEHGEEQRITIEPGTSYRLQGLKPNSLYYFRLAARSPQGLGASTAEISARTMQSMFAKNFHVKAVMKTSVLLSWEIPENYN SAMPFKILYDDGKMVEEVDGRATQKLIVNLKPEKSYSFVLTNRGNSAGGLQHRVTAKTAPDVLRTKPAFIGKTNLDGMITVQLPEVPANE NIKGYYIIIVPLKKSRGKFIKPWESPDEMELDELLKEISRKRRSIRYGREVELKPYIAAHFDVLPTEFTLGDDKHYGGFTNKQLQSGQEY VFFVLAVMEHAESKMYATSPYSDPVVSMDLDPQPITDEEEGLIWVVGPVLAVVFIICIVIAILLYKRKRAESDSRKSSIPNNKEIPSHHP TDPVELRRLNFQTPGSDDSGYPGNLHSSSMASHPPIPILELADHIERLKANDNLKFSQEYESIDPGQQFTWEHSNLEVNKPKNRYANVIA YDHSRVLLSAIEGMLSRWDDSQRFLSDHPYLVCEETAKYLILWCFHLEAEKKGALMEQIAHQAVVMQFIMEMAKNCNVDPRGCFRLFFQK -------------------------------------------------------------- >70342_70342_15_PTPRD-CDC37L1_PTPRD_chr9_8404537_ENST00000486161_CDC37L1_chr9_4697096_ENST00000381854_length(amino acids)=1170AA_BP=1002 MLPSCRMVHVARLLLLLLTFFLRTDAETPPRFTRTPVDQTGVSGGVASFICQATGDPRPKIVWNKKGKKVSNQRFEVIEFDDGSGSVLRI QPLRTPRDEAIYECVASNNVGEISVSTRLTVLREDQIPRGFPTIDMGPQLKVVERTRTATMLCAASGNPDPEITWFKDFLPVDTSNNNGR IKQLRSESIGGTPIRGALQIEQSEESDQGKYECVATNSAGTRYSAPANLYVRELREVRRVPPRFSIPPTNHEIMPGGSVNITCVAVGSPM PYVKWMLGAEDLTPEDDMPIGRNVLELNDVRQSANYTCVAMSTLGVIEAIAQITVKALPKPPGTPVVTESTATSITLTWDSGNPEPVSYY IIQHKPKNSEELYKEIDGVATTRYSVAGLSPYSDYEFRVVAVNNIGRGPPSEPVLTQTSEQAPSSAPRDVQARMLSSTTILVQWKEPEEP NGQIQGYRVYYTMDPTQHVNNWMKHNVADSQITTIGNLVPQKTYSVKVLAFTSIGDGPLSSDIQVITQTGVPGQPLNFKAEPESETSILL SWTPPRSDTIANYELVYKDGEHGEEQRITIEPGTSYRLQGLKPNSLYYFRLAARSPQGLGASTAEISARTMQSMFAKNFHVKAVMKTSVL LSWEIPENYNSAMPFKILYDDGKMVEEVDGRATQKLIVNLKPEKSYSFVLTNRGNSAGGLQHRVTAKTAPDVLRTKPAFIGKTNLDGMIT VQLPEVPANENIKGYYIIIVPLKKSRGKFIKPWESPDEMELDELLKEISRKRRSIRYGREVELKPYIAAHFDVLPTEFTLGDDKHYGGFT NKQLQSGQEYVFFVLAVMEHAESKMYATSPYSDPVVSMDLDPQPITDEEEGLIWVVGPVLAVVFIICIVIAILLYKSKPDRKRAESDSRK SSIPNNKEIPSHHPTDPVELRRLNFQTPGMASHPPIPILELADHIERLKANDNLKFSQEYESIDPGQQFTWEHSNLEVNKPKNRYANVIA YDHSRVLLSAIEGMLSRWDDSQRFLSDHPYLVCEETAKYLILWCFHLEAEKKGALMEQIAHQAVVMQFIMEMAKNCNVDPRGCFRLFFQK AKAEEEGYFEAFKNELEAFKSRVRLYSQSQSFQPMTVQNHVPHSGVGSIGLLESLPQNPDYLQYSISTALCSLNSVVHKEDDEPKMMDTV -------------------------------------------------------------- >70342_70342_16_PTPRD-CDC37L1_PTPRD_chr9_8404537_ENST00000486161_CDC37L1_chr9_4697096_ENST00000381858_length(amino acids)=1141AA_BP=1002 MLPSCRMVHVARLLLLLLTFFLRTDAETPPRFTRTPVDQTGVSGGVASFICQATGDPRPKIVWNKKGKKVSNQRFEVIEFDDGSGSVLRI QPLRTPRDEAIYECVASNNVGEISVSTRLTVLREDQIPRGFPTIDMGPQLKVVERTRTATMLCAASGNPDPEITWFKDFLPVDTSNNNGR IKQLRSESIGGTPIRGALQIEQSEESDQGKYECVATNSAGTRYSAPANLYVRELREVRRVPPRFSIPPTNHEIMPGGSVNITCVAVGSPM PYVKWMLGAEDLTPEDDMPIGRNVLELNDVRQSANYTCVAMSTLGVIEAIAQITVKALPKPPGTPVVTESTATSITLTWDSGNPEPVSYY IIQHKPKNSEELYKEIDGVATTRYSVAGLSPYSDYEFRVVAVNNIGRGPPSEPVLTQTSEQAPSSAPRDVQARMLSSTTILVQWKEPEEP NGQIQGYRVYYTMDPTQHVNNWMKHNVADSQITTIGNLVPQKTYSVKVLAFTSIGDGPLSSDIQVITQTGVPGQPLNFKAEPESETSILL SWTPPRSDTIANYELVYKDGEHGEEQRITIEPGTSYRLQGLKPNSLYYFRLAARSPQGLGASTAEISARTMQSMFAKNFHVKAVMKTSVL LSWEIPENYNSAMPFKILYDDGKMVEEVDGRATQKLIVNLKPEKSYSFVLTNRGNSAGGLQHRVTAKTAPDVLRTKPAFIGKTNLDGMIT VQLPEVPANENIKGYYIIIVPLKKSRGKFIKPWESPDEMELDELLKEISRKRRSIRYGREVELKPYIAAHFDVLPTEFTLGDDKHYGGFT NKQLQSGQEYVFFVLAVMEHAESKMYATSPYSDPVVSMDLDPQPITDEEEGLIWVVGPVLAVVFIICIVIAILLYKSKPDRKRAESDSRK SSIPNNKEIPSHHPTDPVELRRLNFQTPGMASHPPIPILELADHIERLKANDNLKFSQEYESIDPGQQFTWEHSNLEVNKPKNRYANVIA YDHSRVLLSAIEGMLSRWDDSQRFLSDHPYLVCEETAKYLILWCFHLEAEKKGALMEQIAHQAVVMQFIMEMAKNCNVDPRGCFRLFFQK -------------------------------------------------------------- >70342_70342_17_PTPRD-CDC37L1_PTPRD_chr9_8404537_ENST00000537002_CDC37L1_chr9_4697096_ENST00000381854_length(amino acids)=1167AA_BP=999 MLPSCRMVHVARLLLLLLTFFLRTDAETPPRFTRTPVDQTGVSGGVASFICQATGDPRPKIVWNKKGKKVSNQRFEVIEFDDGSGSVLRI QPLRTPRDEAIYECVASNNVGEISVSTRLTVLREDQIPRGFPTIDMGPQLKVVERTRTATMLCAASGNPDPEITWFKDFLPVDTSNNNGR IKQLRSGRVFHTGALQIEQSEESDQGKYECVATNSAGTRYSAPANLYVRVNRKVRRVPPRFSIPPTNHEIMPGGSVNITCVAVGSPMPYV KWMLGAEDLTPEDDMPIGRNVLELNDVRQSANYTCVAMSTLGVIEAIAQITVKALPKPPGTPVVTESTATSITLTWDSGNPEPVSYYIIQ HKPKNSEELYKEIDGVATTRYSVAGLSPYSDYEFRVVAVNNIGRGPPSEPVLTQTSEQAPSSAPRDVQARMLSSTTILVQWKEPEEPNGQ IQGYRVYYTMDPTQHVNNWMKHNVADSQITTIGNLVPQKTYSVKVLAFTSIGDGPLSSDIQVITQTGVPGQPLNFKAEPESETSILLSWT PPRSDTIANYELVYKDGEHGEEQRITIEPGTSYRLQGLKPNSLYYFRLAARSPQGLGASTAEISARTMQSMFAKNFHVKAVMKTSVLLSW EIPENYNSAMPFKILYDDGKMVEEVDGRATQKLIVNLKPEKSYSFVLTNRGNSAGGLQHRVTAKTAPDVLRTKPAFIGKTNLDGMITVQL PEVPANENIKGYYIIIVPLKKSRGKFIKPWESPDEMELDELLKEISRKRRSIRYGREVELKPYIAAHFDVLPTEFTLGDDKHYGGFTNKQ LQSGQEYVFFVLAVMEHAESKMYATSPYSDPVVSMDLDPQPITDEEEGLIWVVGPVLAVVFIICIVIAILLYKRKPYRKRAESDSRKSSI PNNKEIPSHHPTDPVELRRLNFQTPGMASHPPIPILELADHIERLKANDNLKFSQEYESIDPGQQFTWEHSNLEVNKPKNRYANVIAYDH SRVLLSAIEGMLSRWDDSQRFLSDHPYLVCEETAKYLILWCFHLEAEKKGALMEQIAHQAVVMQFIMEMAKNCNVDPRGCFRLFFQKAKA -------------------------------------------------------------- >70342_70342_18_PTPRD-CDC37L1_PTPRD_chr9_8404537_ENST00000537002_CDC37L1_chr9_4697096_ENST00000381858_length(amino acids)=1138AA_BP=999 MLPSCRMVHVARLLLLLLTFFLRTDAETPPRFTRTPVDQTGVSGGVASFICQATGDPRPKIVWNKKGKKVSNQRFEVIEFDDGSGSVLRI QPLRTPRDEAIYECVASNNVGEISVSTRLTVLREDQIPRGFPTIDMGPQLKVVERTRTATMLCAASGNPDPEITWFKDFLPVDTSNNNGR IKQLRSGRVFHTGALQIEQSEESDQGKYECVATNSAGTRYSAPANLYVRVNRKVRRVPPRFSIPPTNHEIMPGGSVNITCVAVGSPMPYV KWMLGAEDLTPEDDMPIGRNVLELNDVRQSANYTCVAMSTLGVIEAIAQITVKALPKPPGTPVVTESTATSITLTWDSGNPEPVSYYIIQ HKPKNSEELYKEIDGVATTRYSVAGLSPYSDYEFRVVAVNNIGRGPPSEPVLTQTSEQAPSSAPRDVQARMLSSTTILVQWKEPEEPNGQ IQGYRVYYTMDPTQHVNNWMKHNVADSQITTIGNLVPQKTYSVKVLAFTSIGDGPLSSDIQVITQTGVPGQPLNFKAEPESETSILLSWT PPRSDTIANYELVYKDGEHGEEQRITIEPGTSYRLQGLKPNSLYYFRLAARSPQGLGASTAEISARTMQSMFAKNFHVKAVMKTSVLLSW EIPENYNSAMPFKILYDDGKMVEEVDGRATQKLIVNLKPEKSYSFVLTNRGNSAGGLQHRVTAKTAPDVLRTKPAFIGKTNLDGMITVQL PEVPANENIKGYYIIIVPLKKSRGKFIKPWESPDEMELDELLKEISRKRRSIRYGREVELKPYIAAHFDVLPTEFTLGDDKHYGGFTNKQ LQSGQEYVFFVLAVMEHAESKMYATSPYSDPVVSMDLDPQPITDEEEGLIWVVGPVLAVVFIICIVIAILLYKRKPYRKRAESDSRKSSI PNNKEIPSHHPTDPVELRRLNFQTPGMASHPPIPILELADHIERLKANDNLKFSQEYESIDPGQQFTWEHSNLEVNKPKNRYANVIAYDH SRVLLSAIEGMLSRWDDSQRFLSDHPYLVCEETAKYLILWCFHLEAEKKGALMEQIAHQAVVMQFIMEMAKNCNVDPRGCFRLFFQKAKA -------------------------------------------------------------- |
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Fusion Protein Functional Features |
Four levels of functional features of fusion genes Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr9:8404537/chr9:4697096) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
Main function of each fusion partner protein. (from UniProt) |
Hgene | Tgene |
. | CDC37L1 |
FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes. | FUNCTION: Co-chaperone that binds to numerous proteins and promotes their interaction with Hsp70 and Hsp90. {ECO:0000250}. |
Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
- Retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Hgene | PTPRD | chr9:8404537 | chr9:4697096 | ENST00000355233 | - | 21 | 31 | 126_224 | 997.3333333333334 | 1507.0 | Domain | Note=Ig-like C2-type 2 |
Hgene | PTPRD | chr9:8404537 | chr9:4697096 | ENST00000355233 | - | 21 | 31 | 236_318 | 997.3333333333334 | 1507.0 | Domain | Note=Ig-like C2-type 3 |
Hgene | PTPRD | chr9:8404537 | chr9:4697096 | ENST00000355233 | - | 21 | 31 | 24_114 | 997.3333333333334 | 1507.0 | Domain | Note=Ig-like C2-type 1 |
Hgene | PTPRD | chr9:8404537 | chr9:4697096 | ENST00000355233 | - | 21 | 31 | 325_415 | 997.3333333333334 | 1507.0 | Domain | Fibronectin type-III 1 |
Hgene | PTPRD | chr9:8404537 | chr9:4697096 | ENST00000355233 | - | 21 | 31 | 420_516 | 997.3333333333334 | 1507.0 | Domain | Fibronectin type-III 2 |
Hgene | PTPRD | chr9:8404537 | chr9:4697096 | ENST00000355233 | - | 21 | 31 | 518_607 | 997.3333333333334 | 1507.0 | Domain | Fibronectin type-III 3 |
Hgene | PTPRD | chr9:8404537 | chr9:4697096 | ENST00000355233 | - | 21 | 31 | 612_709 | 997.3333333333334 | 1507.0 | Domain | Fibronectin type-III 4 |
Hgene | PTPRD | chr9:8404537 | chr9:4697096 | ENST00000355233 | - | 21 | 31 | 714_822 | 997.3333333333334 | 1507.0 | Domain | Fibronectin type-III 5 |
Hgene | PTPRD | chr9:8404537 | chr9:4697096 | ENST00000355233 | - | 21 | 31 | 823_916 | 997.3333333333334 | 1507.0 | Domain | Fibronectin type-III 6 |
Hgene | PTPRD | chr9:8404537 | chr9:4697096 | ENST00000356435 | - | 25 | 35 | 1020_1106 | 1403.3333333333333 | 1913.0 | Domain | Fibronectin type-III 8 |
Hgene | PTPRD | chr9:8404537 | chr9:4697096 | ENST00000356435 | - | 25 | 35 | 126_224 | 1403.3333333333333 | 1913.0 | Domain | Note=Ig-like C2-type 2 |
Hgene | PTPRD | chr9:8404537 | chr9:4697096 | ENST00000356435 | - | 25 | 35 | 236_318 | 1403.3333333333333 | 1913.0 | Domain | Note=Ig-like C2-type 3 |
Hgene | PTPRD | chr9:8404537 | chr9:4697096 | ENST00000356435 | - | 25 | 35 | 24_114 | 1403.3333333333333 | 1913.0 | Domain | Note=Ig-like C2-type 1 |
Hgene | PTPRD | chr9:8404537 | chr9:4697096 | ENST00000356435 | - | 25 | 35 | 325_415 | 1403.3333333333333 | 1913.0 | Domain | Fibronectin type-III 1 |
Hgene | PTPRD | chr9:8404537 | chr9:4697096 | ENST00000356435 | - | 25 | 35 | 420_516 | 1403.3333333333333 | 1913.0 | Domain | Fibronectin type-III 2 |
Hgene | PTPRD | chr9:8404537 | chr9:4697096 | ENST00000356435 | - | 25 | 35 | 518_607 | 1403.3333333333333 | 1913.0 | Domain | Fibronectin type-III 3 |
Hgene | PTPRD | chr9:8404537 | chr9:4697096 | ENST00000356435 | - | 25 | 35 | 612_709 | 1403.3333333333333 | 1913.0 | Domain | Fibronectin type-III 4 |
Hgene | PTPRD | chr9:8404537 | chr9:4697096 | ENST00000356435 | - | 25 | 35 | 714_822 | 1403.3333333333333 | 1913.0 | Domain | Fibronectin type-III 5 |
Hgene | PTPRD | chr9:8404537 | chr9:4697096 | ENST00000356435 | - | 25 | 35 | 823_916 | 1403.3333333333333 | 1913.0 | Domain | Fibronectin type-III 6 |
Hgene | PTPRD | chr9:8404537 | chr9:4697096 | ENST00000356435 | - | 25 | 35 | 921_1016 | 1403.3333333333333 | 1913.0 | Domain | Fibronectin type-III 7 |
Hgene | PTPRD | chr9:8404537 | chr9:4697096 | ENST00000381196 | - | 33 | 43 | 1020_1106 | 1403.3333333333333 | 1913.0 | Domain | Fibronectin type-III 8 |
Hgene | PTPRD | chr9:8404537 | chr9:4697096 | ENST00000381196 | - | 33 | 43 | 126_224 | 1403.3333333333333 | 1913.0 | Domain | Note=Ig-like C2-type 2 |
Hgene | PTPRD | chr9:8404537 | chr9:4697096 | ENST00000381196 | - | 33 | 43 | 236_318 | 1403.3333333333333 | 1913.0 | Domain | Note=Ig-like C2-type 3 |
Hgene | PTPRD | chr9:8404537 | chr9:4697096 | ENST00000381196 | - | 33 | 43 | 24_114 | 1403.3333333333333 | 1913.0 | Domain | Note=Ig-like C2-type 1 |
Hgene | PTPRD | chr9:8404537 | chr9:4697096 | ENST00000381196 | - | 33 | 43 | 325_415 | 1403.3333333333333 | 1913.0 | Domain | Fibronectin type-III 1 |
Hgene | PTPRD | chr9:8404537 | chr9:4697096 | ENST00000381196 | - | 33 | 43 | 420_516 | 1403.3333333333333 | 1913.0 | Domain | Fibronectin type-III 2 |
Hgene | PTPRD | chr9:8404537 | chr9:4697096 | ENST00000381196 | - | 33 | 43 | 518_607 | 1403.3333333333333 | 1913.0 | Domain | Fibronectin type-III 3 |
Hgene | PTPRD | chr9:8404537 | chr9:4697096 | ENST00000381196 | - | 33 | 43 | 612_709 | 1403.3333333333333 | 1913.0 | Domain | Fibronectin type-III 4 |
Hgene | PTPRD | chr9:8404537 | chr9:4697096 | ENST00000381196 | - | 33 | 43 | 714_822 | 1403.3333333333333 | 1913.0 | Domain | Fibronectin type-III 5 |
Hgene | PTPRD | chr9:8404537 | chr9:4697096 | ENST00000381196 | - | 33 | 43 | 823_916 | 1403.3333333333333 | 1913.0 | Domain | Fibronectin type-III 6 |
Hgene | PTPRD | chr9:8404537 | chr9:4697096 | ENST00000381196 | - | 33 | 43 | 921_1016 | 1403.3333333333333 | 1913.0 | Domain | Fibronectin type-III 7 |
Hgene | PTPRD | chr9:8404537 | chr9:4697096 | ENST00000397606 | - | 19 | 29 | 126_224 | 996.3333333333334 | 1506.0 | Domain | Note=Ig-like C2-type 2 |
Hgene | PTPRD | chr9:8404537 | chr9:4697096 | ENST00000397606 | - | 19 | 29 | 236_318 | 996.3333333333334 | 1506.0 | Domain | Note=Ig-like C2-type 3 |
Hgene | PTPRD | chr9:8404537 | chr9:4697096 | ENST00000397606 | - | 19 | 29 | 24_114 | 996.3333333333334 | 1506.0 | Domain | Note=Ig-like C2-type 1 |
Hgene | PTPRD | chr9:8404537 | chr9:4697096 | ENST00000397606 | - | 19 | 29 | 325_415 | 996.3333333333334 | 1506.0 | Domain | Fibronectin type-III 1 |
Hgene | PTPRD | chr9:8404537 | chr9:4697096 | ENST00000397606 | - | 19 | 29 | 420_516 | 996.3333333333334 | 1506.0 | Domain | Fibronectin type-III 2 |
Hgene | PTPRD | chr9:8404537 | chr9:4697096 | ENST00000397606 | - | 19 | 29 | 518_607 | 996.3333333333334 | 1506.0 | Domain | Fibronectin type-III 3 |
Hgene | PTPRD | chr9:8404537 | chr9:4697096 | ENST00000397606 | - | 19 | 29 | 612_709 | 996.3333333333334 | 1506.0 | Domain | Fibronectin type-III 4 |
Hgene | PTPRD | chr9:8404537 | chr9:4697096 | ENST00000397606 | - | 19 | 29 | 714_822 | 996.3333333333334 | 1506.0 | Domain | Fibronectin type-III 5 |
Hgene | PTPRD | chr9:8404537 | chr9:4697096 | ENST00000397606 | - | 19 | 29 | 823_916 | 996.3333333333334 | 1506.0 | Domain | Fibronectin type-III 6 |
Hgene | PTPRD | chr9:8404537 | chr9:4697096 | ENST00000486161 | - | 21 | 31 | 126_224 | 996.3333333333334 | 1506.0 | Domain | Note=Ig-like C2-type 2 |
Hgene | PTPRD | chr9:8404537 | chr9:4697096 | ENST00000486161 | - | 21 | 31 | 236_318 | 996.3333333333334 | 1506.0 | Domain | Note=Ig-like C2-type 3 |
Hgene | PTPRD | chr9:8404537 | chr9:4697096 | ENST00000486161 | - | 21 | 31 | 24_114 | 996.3333333333334 | 1506.0 | Domain | Note=Ig-like C2-type 1 |
Hgene | PTPRD | chr9:8404537 | chr9:4697096 | ENST00000486161 | - | 21 | 31 | 325_415 | 996.3333333333334 | 1506.0 | Domain | Fibronectin type-III 1 |
Hgene | PTPRD | chr9:8404537 | chr9:4697096 | ENST00000486161 | - | 21 | 31 | 420_516 | 996.3333333333334 | 1506.0 | Domain | Fibronectin type-III 2 |
Hgene | PTPRD | chr9:8404537 | chr9:4697096 | ENST00000486161 | - | 21 | 31 | 518_607 | 996.3333333333334 | 1506.0 | Domain | Fibronectin type-III 3 |
Hgene | PTPRD | chr9:8404537 | chr9:4697096 | ENST00000486161 | - | 21 | 31 | 612_709 | 996.3333333333334 | 1506.0 | Domain | Fibronectin type-III 4 |
Hgene | PTPRD | chr9:8404537 | chr9:4697096 | ENST00000486161 | - | 21 | 31 | 714_822 | 996.3333333333334 | 1506.0 | Domain | Fibronectin type-III 5 |
Hgene | PTPRD | chr9:8404537 | chr9:4697096 | ENST00000486161 | - | 21 | 31 | 823_916 | 996.3333333333334 | 1506.0 | Domain | Fibronectin type-III 6 |
Hgene | PTPRD | chr9:8404537 | chr9:4697096 | ENST00000540109 | - | 25 | 36 | 1020_1106 | 1403.3333333333333 | 1952.3333333333333 | Domain | Fibronectin type-III 8 |
Hgene | PTPRD | chr9:8404537 | chr9:4697096 | ENST00000540109 | - | 25 | 36 | 126_224 | 1403.3333333333333 | 1952.3333333333333 | Domain | Note=Ig-like C2-type 2 |
Hgene | PTPRD | chr9:8404537 | chr9:4697096 | ENST00000540109 | - | 25 | 36 | 236_318 | 1403.3333333333333 | 1952.3333333333333 | Domain | Note=Ig-like C2-type 3 |
Hgene | PTPRD | chr9:8404537 | chr9:4697096 | ENST00000540109 | - | 25 | 36 | 24_114 | 1403.3333333333333 | 1952.3333333333333 | Domain | Note=Ig-like C2-type 1 |
Hgene | PTPRD | chr9:8404537 | chr9:4697096 | ENST00000540109 | - | 25 | 36 | 325_415 | 1403.3333333333333 | 1952.3333333333333 | Domain | Fibronectin type-III 1 |
Hgene | PTPRD | chr9:8404537 | chr9:4697096 | ENST00000540109 | - | 25 | 36 | 420_516 | 1403.3333333333333 | 1952.3333333333333 | Domain | Fibronectin type-III 2 |
Hgene | PTPRD | chr9:8404537 | chr9:4697096 | ENST00000540109 | - | 25 | 36 | 518_607 | 1403.3333333333333 | 1952.3333333333333 | Domain | Fibronectin type-III 3 |
Hgene | PTPRD | chr9:8404537 | chr9:4697096 | ENST00000540109 | - | 25 | 36 | 612_709 | 1403.3333333333333 | 1952.3333333333333 | Domain | Fibronectin type-III 4 |
Hgene | PTPRD | chr9:8404537 | chr9:4697096 | ENST00000540109 | - | 25 | 36 | 714_822 | 1403.3333333333333 | 1952.3333333333333 | Domain | Fibronectin type-III 5 |
Hgene | PTPRD | chr9:8404537 | chr9:4697096 | ENST00000540109 | - | 25 | 36 | 823_916 | 1403.3333333333333 | 1952.3333333333333 | Domain | Fibronectin type-III 6 |
Hgene | PTPRD | chr9:8404537 | chr9:4697096 | ENST00000540109 | - | 25 | 36 | 921_1016 | 1403.3333333333333 | 1952.3333333333333 | Domain | Fibronectin type-III 7 |
Hgene | PTPRD | chr9:8404537 | chr9:4697096 | ENST00000356435 | - | 25 | 35 | 21_1265 | 1403.3333333333333 | 1913.0 | Topological domain | Extracellular |
Hgene | PTPRD | chr9:8404537 | chr9:4697096 | ENST00000381196 | - | 33 | 43 | 21_1265 | 1403.3333333333333 | 1913.0 | Topological domain | Extracellular |
Hgene | PTPRD | chr9:8404537 | chr9:4697096 | ENST00000540109 | - | 25 | 36 | 21_1265 | 1403.3333333333333 | 1952.3333333333333 | Topological domain | Extracellular |
Hgene | PTPRD | chr9:8404537 | chr9:4697096 | ENST00000356435 | - | 25 | 35 | 1266_1290 | 1403.3333333333333 | 1913.0 | Transmembrane | Helical |
Hgene | PTPRD | chr9:8404537 | chr9:4697096 | ENST00000381196 | - | 33 | 43 | 1266_1290 | 1403.3333333333333 | 1913.0 | Transmembrane | Helical |
Hgene | PTPRD | chr9:8404537 | chr9:4697096 | ENST00000540109 | - | 25 | 36 | 1266_1290 | 1403.3333333333333 | 1952.3333333333333 | Transmembrane | Helical |
- Not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Hgene | PTPRD | chr9:8404537 | chr9:4697096 | ENST00000355233 | - | 21 | 31 | 1020_1106 | 997.3333333333334 | 1507.0 | Domain | Fibronectin type-III 8 |
Hgene | PTPRD | chr9:8404537 | chr9:4697096 | ENST00000355233 | - | 21 | 31 | 1357_1612 | 997.3333333333334 | 1507.0 | Domain | Tyrosine-protein phosphatase 1 |
Hgene | PTPRD | chr9:8404537 | chr9:4697096 | ENST00000355233 | - | 21 | 31 | 1644_1903 | 997.3333333333334 | 1507.0 | Domain | Tyrosine-protein phosphatase 2 |
Hgene | PTPRD | chr9:8404537 | chr9:4697096 | ENST00000355233 | - | 21 | 31 | 921_1016 | 997.3333333333334 | 1507.0 | Domain | Fibronectin type-III 7 |
Hgene | PTPRD | chr9:8404537 | chr9:4697096 | ENST00000356435 | - | 25 | 35 | 1357_1612 | 1403.3333333333333 | 1913.0 | Domain | Tyrosine-protein phosphatase 1 |
Hgene | PTPRD | chr9:8404537 | chr9:4697096 | ENST00000356435 | - | 25 | 35 | 1644_1903 | 1403.3333333333333 | 1913.0 | Domain | Tyrosine-protein phosphatase 2 |
Hgene | PTPRD | chr9:8404537 | chr9:4697096 | ENST00000381196 | - | 33 | 43 | 1357_1612 | 1403.3333333333333 | 1913.0 | Domain | Tyrosine-protein phosphatase 1 |
Hgene | PTPRD | chr9:8404537 | chr9:4697096 | ENST00000381196 | - | 33 | 43 | 1644_1903 | 1403.3333333333333 | 1913.0 | Domain | Tyrosine-protein phosphatase 2 |
Hgene | PTPRD | chr9:8404537 | chr9:4697096 | ENST00000397606 | - | 19 | 29 | 1020_1106 | 996.3333333333334 | 1506.0 | Domain | Fibronectin type-III 8 |
Hgene | PTPRD | chr9:8404537 | chr9:4697096 | ENST00000397606 | - | 19 | 29 | 1357_1612 | 996.3333333333334 | 1506.0 | Domain | Tyrosine-protein phosphatase 1 |
Hgene | PTPRD | chr9:8404537 | chr9:4697096 | ENST00000397606 | - | 19 | 29 | 1644_1903 | 996.3333333333334 | 1506.0 | Domain | Tyrosine-protein phosphatase 2 |
Hgene | PTPRD | chr9:8404537 | chr9:4697096 | ENST00000397606 | - | 19 | 29 | 921_1016 | 996.3333333333334 | 1506.0 | Domain | Fibronectin type-III 7 |
Hgene | PTPRD | chr9:8404537 | chr9:4697096 | ENST00000486161 | - | 21 | 31 | 1020_1106 | 996.3333333333334 | 1506.0 | Domain | Fibronectin type-III 8 |
Hgene | PTPRD | chr9:8404537 | chr9:4697096 | ENST00000486161 | - | 21 | 31 | 1357_1612 | 996.3333333333334 | 1506.0 | Domain | Tyrosine-protein phosphatase 1 |
Hgene | PTPRD | chr9:8404537 | chr9:4697096 | ENST00000486161 | - | 21 | 31 | 1644_1903 | 996.3333333333334 | 1506.0 | Domain | Tyrosine-protein phosphatase 2 |
Hgene | PTPRD | chr9:8404537 | chr9:4697096 | ENST00000486161 | - | 21 | 31 | 921_1016 | 996.3333333333334 | 1506.0 | Domain | Fibronectin type-III 7 |
Hgene | PTPRD | chr9:8404537 | chr9:4697096 | ENST00000540109 | - | 25 | 36 | 1357_1612 | 1403.3333333333333 | 1952.3333333333333 | Domain | Tyrosine-protein phosphatase 1 |
Hgene | PTPRD | chr9:8404537 | chr9:4697096 | ENST00000540109 | - | 25 | 36 | 1644_1903 | 1403.3333333333333 | 1952.3333333333333 | Domain | Tyrosine-protein phosphatase 2 |
Hgene | PTPRD | chr9:8404537 | chr9:4697096 | ENST00000355233 | - | 21 | 31 | 1553_1559 | 997.3333333333334 | 1507.0 | Region | Substrate binding |
Hgene | PTPRD | chr9:8404537 | chr9:4697096 | ENST00000356435 | - | 25 | 35 | 1553_1559 | 1403.3333333333333 | 1913.0 | Region | Substrate binding |
Hgene | PTPRD | chr9:8404537 | chr9:4697096 | ENST00000381196 | - | 33 | 43 | 1553_1559 | 1403.3333333333333 | 1913.0 | Region | Substrate binding |
Hgene | PTPRD | chr9:8404537 | chr9:4697096 | ENST00000397606 | - | 19 | 29 | 1553_1559 | 996.3333333333334 | 1506.0 | Region | Substrate binding |
Hgene | PTPRD | chr9:8404537 | chr9:4697096 | ENST00000486161 | - | 21 | 31 | 1553_1559 | 996.3333333333334 | 1506.0 | Region | Substrate binding |
Hgene | PTPRD | chr9:8404537 | chr9:4697096 | ENST00000540109 | - | 25 | 36 | 1553_1559 | 1403.3333333333333 | 1952.3333333333333 | Region | Substrate binding |
Hgene | PTPRD | chr9:8404537 | chr9:4697096 | ENST00000355233 | - | 21 | 31 | 1291_1912 | 997.3333333333334 | 1507.0 | Topological domain | Cytoplasmic |
Hgene | PTPRD | chr9:8404537 | chr9:4697096 | ENST00000355233 | - | 21 | 31 | 21_1265 | 997.3333333333334 | 1507.0 | Topological domain | Extracellular |
Hgene | PTPRD | chr9:8404537 | chr9:4697096 | ENST00000356435 | - | 25 | 35 | 1291_1912 | 1403.3333333333333 | 1913.0 | Topological domain | Cytoplasmic |
Hgene | PTPRD | chr9:8404537 | chr9:4697096 | ENST00000381196 | - | 33 | 43 | 1291_1912 | 1403.3333333333333 | 1913.0 | Topological domain | Cytoplasmic |
Hgene | PTPRD | chr9:8404537 | chr9:4697096 | ENST00000397606 | - | 19 | 29 | 1291_1912 | 996.3333333333334 | 1506.0 | Topological domain | Cytoplasmic |
Hgene | PTPRD | chr9:8404537 | chr9:4697096 | ENST00000397606 | - | 19 | 29 | 21_1265 | 996.3333333333334 | 1506.0 | Topological domain | Extracellular |
Hgene | PTPRD | chr9:8404537 | chr9:4697096 | ENST00000486161 | - | 21 | 31 | 1291_1912 | 996.3333333333334 | 1506.0 | Topological domain | Cytoplasmic |
Hgene | PTPRD | chr9:8404537 | chr9:4697096 | ENST00000486161 | - | 21 | 31 | 21_1265 | 996.3333333333334 | 1506.0 | Topological domain | Extracellular |
Hgene | PTPRD | chr9:8404537 | chr9:4697096 | ENST00000540109 | - | 25 | 36 | 1291_1912 | 1403.3333333333333 | 1952.3333333333333 | Topological domain | Cytoplasmic |
Hgene | PTPRD | chr9:8404537 | chr9:4697096 | ENST00000355233 | - | 21 | 31 | 1266_1290 | 997.3333333333334 | 1507.0 | Transmembrane | Helical |
Hgene | PTPRD | chr9:8404537 | chr9:4697096 | ENST00000397606 | - | 19 | 29 | 1266_1290 | 996.3333333333334 | 1506.0 | Transmembrane | Helical |
Hgene | PTPRD | chr9:8404537 | chr9:4697096 | ENST00000486161 | - | 21 | 31 | 1266_1290 | 996.3333333333334 | 1506.0 | Transmembrane | Helical |
Tgene | CDC37L1 | chr9:8404537 | chr9:4697096 | ENST00000381854 | 2 | 7 | 84_122 | 169.33333333333334 | 338.0 | Coiled coil | Ontology_term=ECO:0000255 | |
Tgene | CDC37L1 | chr9:8404537 | chr9:4697096 | ENST00000381854 | 2 | 7 | 2_171 | 169.33333333333334 | 338.0 | Region | Note=Self-association |
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Fusion Protein-Protein Interaction |
Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in |
Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160) |
Gene | PPI interactors |
Protein-protein interactors based on sequence similarity (STRING) |
Gene | STRING network |
PTPRD | |
CDC37L1 |
- Retained interactions in fusion protein (protein functional feature from UniProt). |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
- Lost interactions due to fusion (protein functional feature from UniProt). |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs to PTPRD-CDC37L1 |
Drugs used for this fusion-positive patient. (Manual curation of PubMed, 04-30-2022 + MyCancerGenome) |
Hgene | Tgene | Drug | Source | PMID |
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Related Diseases to PTPRD-CDC37L1 |
Diseases that have this fusion gene. (Manual curation of PubMed, 04-30-2022 + MyCancerGenome) |
Hgene | Tgene | Disease | Source | PMID |
Diseases associated with fusion partners. (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |