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	Fusion Gene Summary
	Fusion Gene Sample Information
	Fusion ORF Analysis
	Fusion Amino Acid Sequences
	Fusion Protein Functional Features
	Fusion Protein-Protein Interaction
	Related drugs with this fusion protein
	Related disease with this fusion protein

Fusion Protein:PTPRD-IDO1

Fusion Protein Summary

Fusion gene summary

Fusion partner gene information	Fusion gene name: PTPRD-IDO1
	FusionPDB ID: 70349
	FusionGDB2.0 ID: 70349
		Hgene	Tgene
	Gene symbol	PTPRD	IDO1
	Gene ID	5789	3620
	Gene name	protein tyrosine phosphatase receptor type D	indoleamine 2,3-dioxygenase 1
	Synonyms	HPTP\|HPTPD\|HPTPDELTA\|PTPD\|R-PTP-delta\|RPTPDELTA	IDO\|IDO-1\|INDO
	Cytomap	9p24.1-p23	8p11.21
	Type of gene	protein-coding	protein-coding
	Description	receptor-type tyrosine-protein phosphatase deltaprotein tyrosine phosphatase, receptor type, delta polypeptiderceptor-type tyrosine-protein phosphatase delta	indoleamine 2,3-dioxygenase 1indolamine 2,3 dioxygenaseindole 2,3-dioxygenaseindoleamine-pyrrole 2,3-dioxygenase
	Modification date	20200320	20200322
	UniProtAcc	.	P14902
Ensembl transtripts involved in fusion gene	ENST ids	ENST00000355233, ENST00000356435, ENST00000358503, ENST00000360074, ENST00000381196, ENST00000397606, ENST00000397611, ENST00000397617, ENST00000463477, ENST00000486161, ENST00000537002, ENST00000540109, ENST00000471274,	ENST00000518237, ENST00000522495,
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)	* DoF score	26 X 25 X 7=4550	5 X 6 X 5=150
	# samples	28	6
	** MAII score	log2(28/4550*10)=-4.02236781302845 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(6/150*10)=-1.32192809488736 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)	PubMed: PTPRD [Title/Abstract] AND IDO1 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)	PTPRD(8733780)-IDO1(39771408), # samples:3
Anticipated loss of major functional domain due to fusion event.	PTPRD-IDO1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. PTPRD-IDO1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. PTPRD-IDO1 seems lost the major protein functional domain in Hgene partner, which is a CGC due to the frame-shifted ORF. PTPRD-IDO1 seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF. PTPRD-IDO1 seems lost the major protein functional domain in Hgene partner, which is a tumor suppressor due to the frame-shifted ORF. PTPRD-IDO1 seems lost the major protein functional domain in Tgene partner, which is a cell metabolism gene due to the frame-shifted ORF. PTPRD-IDO1 seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	PTPRD	GO:0099545	trans-synaptic signaling by trans-synaptic complex	21926414
Hgene	PTPRD	GO:0099560	synaptic membrane adhesion	23345436
Hgene	PTPRD	GO:1905606	regulation of presynapse assembly	21926414

Fusion gene breakpoints across PTPRD (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across IDO1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

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Fusion Gene Sample Information

Fusion gene information from FusionGDB2.0.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	HNSC	TCGA-CV-7407-01A	PTPRD	chr9	8733780	-	IDO1	chr8	39771408	+
ChimerDB4	HNSC	TCGA-CV-7407	PTPRD	chr9	8733780	-	IDO1	chr8	39771408	+
ChimerDB4	HNSC	TCGA-CV-7407	PTPRD	chr9	8733780	-	IDO1	chr8	39775394	+

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Fusion ORF Analysis

Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000381196	PTPRD	chr9	8733780	-	ENST00000522495	IDO1	chr8	39775394	+	1974	608	599	1732	377
ENST00000381196	PTPRD	chr9	8733780	-	ENST00000518237	IDO1	chr8	39775394	+	1979	608	599	1732	377
ENST00000360074	PTPRD	chr9	8733780	-	ENST00000522495	IDO1	chr8	39775394	+	1533	167	158	1291	377
ENST00000360074	PTPRD	chr9	8733780	-	ENST00000518237	IDO1	chr8	39775394	+	1538	167	158	1291	377
ENST00000537002	PTPRD	chr9	8733780	-	ENST00000522495	IDO1	chr8	39775394	+	1533	167	158	1291	377
ENST00000537002	PTPRD	chr9	8733780	-	ENST00000518237	IDO1	chr8	39775394	+	1538	167	158	1291	377
ENST00000397617	PTPRD	chr9	8733780	-	ENST00000522495	IDO1	chr8	39775394	+	1533	167	158	1291	377
ENST00000397617	PTPRD	chr9	8733780	-	ENST00000518237	IDO1	chr8	39775394	+	1538	167	158	1291	377
ENST00000358503	PTPRD	chr9	8733780	-	ENST00000522495	IDO1	chr8	39775394	+	1533	167	158	1291	377
ENST00000358503	PTPRD	chr9	8733780	-	ENST00000518237	IDO1	chr8	39775394	+	1538	167	158	1291	377
ENST00000397611	PTPRD	chr9	8733780	-	ENST00000522495	IDO1	chr8	39775394	+	1533	167	158	1291	377
ENST00000397611	PTPRD	chr9	8733780	-	ENST00000518237	IDO1	chr8	39775394	+	1538	167	158	1291	377
ENST00000355233	PTPRD	chr9	8733780	-	ENST00000522495	IDO1	chr8	39775394	+	1533	167	158	1291	377
ENST00000355233	PTPRD	chr9	8733780	-	ENST00000518237	IDO1	chr8	39775394	+	1538	167	158	1291	377
ENST00000356435	PTPRD	chr9	8733780	-	ENST00000522495	IDO1	chr8	39775394	+	1536	170	161	1294	377
ENST00000356435	PTPRD	chr9	8733780	-	ENST00000518237	IDO1	chr8	39775394	+	1541	170	161	1294	377
ENST00000540109	PTPRD	chr9	8733780	-	ENST00000522495	IDO1	chr8	39775394	+	1536	170	161	1294	377
ENST00000540109	PTPRD	chr9	8733780	-	ENST00000518237	IDO1	chr8	39775394	+	1541	170	161	1294	377
ENST00000486161	PTPRD	chr9	8733780	-	ENST00000522495	IDO1	chr8	39775394	+	1481	115	106	1239	377
ENST00000486161	PTPRD	chr9	8733780	-	ENST00000518237	IDO1	chr8	39775394	+	1486	115	106	1239	377
ENST00000397606	PTPRD	chr9	8733780	-	ENST00000522495	IDO1	chr8	39775394	+	1481	115	106	1239	377
ENST00000397606	PTPRD	chr9	8733780	-	ENST00000518237	IDO1	chr8	39775394	+	1486	115	106	1239	377

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000381196	ENST00000522495	PTPRD	chr9	8733780	-	IDO1	chr8	39775394	+	0.001311743	0.9986883
ENST00000381196	ENST00000518237	PTPRD	chr9	8733780	-	IDO1	chr8	39775394	+	0.001303846	0.99869615
ENST00000360074	ENST00000522495	PTPRD	chr9	8733780	-	IDO1	chr8	39775394	+	0.001178035	0.9988219
ENST00000360074	ENST00000518237	PTPRD	chr9	8733780	-	IDO1	chr8	39775394	+	0.001187797	0.9988122
ENST00000537002	ENST00000522495	PTPRD	chr9	8733780	-	IDO1	chr8	39775394	+	0.001178035	0.9988219
ENST00000537002	ENST00000518237	PTPRD	chr9	8733780	-	IDO1	chr8	39775394	+	0.001187797	0.9988122
ENST00000397617	ENST00000522495	PTPRD	chr9	8733780	-	IDO1	chr8	39775394	+	0.001178035	0.9988219
ENST00000397617	ENST00000518237	PTPRD	chr9	8733780	-	IDO1	chr8	39775394	+	0.001187797	0.9988122
ENST00000358503	ENST00000522495	PTPRD	chr9	8733780	-	IDO1	chr8	39775394	+	0.001178035	0.9988219
ENST00000358503	ENST00000518237	PTPRD	chr9	8733780	-	IDO1	chr8	39775394	+	0.001187797	0.9988122
ENST00000397611	ENST00000522495	PTPRD	chr9	8733780	-	IDO1	chr8	39775394	+	0.001178035	0.9988219
ENST00000397611	ENST00000518237	PTPRD	chr9	8733780	-	IDO1	chr8	39775394	+	0.001187797	0.9988122
ENST00000355233	ENST00000522495	PTPRD	chr9	8733780	-	IDO1	chr8	39775394	+	0.001178035	0.9988219
ENST00000355233	ENST00000518237	PTPRD	chr9	8733780	-	IDO1	chr8	39775394	+	0.001187797	0.9988122
ENST00000356435	ENST00000522495	PTPRD	chr9	8733780	-	IDO1	chr8	39775394	+	0.001199554	0.9988004
ENST00000356435	ENST00000518237	PTPRD	chr9	8733780	-	IDO1	chr8	39775394	+	0.00120665	0.99879336
ENST00000540109	ENST00000522495	PTPRD	chr9	8733780	-	IDO1	chr8	39775394	+	0.001199554	0.9988004
ENST00000540109	ENST00000518237	PTPRD	chr9	8733780	-	IDO1	chr8	39775394	+	0.00120665	0.99879336
ENST00000486161	ENST00000522495	PTPRD	chr9	8733780	-	IDO1	chr8	39775394	+	0.001045107	0.9989549
ENST00000486161	ENST00000518237	PTPRD	chr9	8733780	-	IDO1	chr8	39775394	+	0.001053973	0.998946
ENST00000397606	ENST00000522495	PTPRD	chr9	8733780	-	IDO1	chr8	39775394	+	0.001045107	0.9989549
ENST00000397606	ENST00000518237	PTPRD	chr9	8733780	-	IDO1	chr8	39775394	+	0.001053973	0.998946

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Fusion Amino Acid Sequences

For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>70349_70349_1_PTPRD-IDO1_PTPRD_chr9_8733780_ENST00000355233_IDO1_chr8_39775394_ENST00000518237_length(amino acids)=377AA_BP=3
MLRENLPDFYNDWMFIAKHLPDLIESGQLRERVEKLNMLSIDHLTDHKSQRLARLVLGCITMAYVWGKGHGDVRKVLPRNIAVPYCQLSK
KLELPPILVYADCVLANWKKKDPNKPLTYENMDVLFSFRDGDCSKGFFLVSLLVEIAAASAIKVIPTVFKAMQMQERDTLLKALLEIASC
LEKALQVFHQIHDHVNPKAFFSVLRIYLSGWKGNPQLSDGLVYEGFWEDPKEFAGGSAGQSSVFQCFDVLLGIQQTAGGGHAAQFLQDMR
RYMPPAHRNFLCSLESNPSVREFVLSKGDAGLREAYDACVKALVSLRSYHLQIVTKYILIPASQQPKENKTSEDPSKLEAKGTGGTDLMN

--------------------------------------------------------------

>70349_70349_2_PTPRD-IDO1_PTPRD_chr9_8733780_ENST00000355233_IDO1_chr8_39775394_ENST00000522495_length(amino acids)=377AA_BP=3
MLRENLPDFYNDWMFIAKHLPDLIESGQLRERVEKLNMLSIDHLTDHKSQRLARLVLGCITMAYVWGKGHGDVRKVLPRNIAVPYCQLSK
KLELPPILVYADCVLANWKKKDPNKPLTYENMDVLFSFRDGDCSKGFFLVSLLVEIAAASAIKVIPTVFKAMQMQERDTLLKALLEIASC
LEKALQVFHQIHDHVNPKAFFSVLRIYLSGWKGNPQLSDGLVYEGFWEDPKEFAGGSAGQSSVFQCFDVLLGIQQTAGGGHAAQFLQDMR
RYMPPAHRNFLCSLESNPSVREFVLSKGDAGLREAYDACVKALVSLRSYHLQIVTKYILIPASQQPKENKTSEDPSKLEAKGTGGTDLMN

--------------------------------------------------------------

>70349_70349_3_PTPRD-IDO1_PTPRD_chr9_8733780_ENST00000356435_IDO1_chr8_39775394_ENST00000518237_length(amino acids)=377AA_BP=3
MLRENLPDFYNDWMFIAKHLPDLIESGQLRERVEKLNMLSIDHLTDHKSQRLARLVLGCITMAYVWGKGHGDVRKVLPRNIAVPYCQLSK
KLELPPILVYADCVLANWKKKDPNKPLTYENMDVLFSFRDGDCSKGFFLVSLLVEIAAASAIKVIPTVFKAMQMQERDTLLKALLEIASC
LEKALQVFHQIHDHVNPKAFFSVLRIYLSGWKGNPQLSDGLVYEGFWEDPKEFAGGSAGQSSVFQCFDVLLGIQQTAGGGHAAQFLQDMR
RYMPPAHRNFLCSLESNPSVREFVLSKGDAGLREAYDACVKALVSLRSYHLQIVTKYILIPASQQPKENKTSEDPSKLEAKGTGGTDLMN

--------------------------------------------------------------

>70349_70349_4_PTPRD-IDO1_PTPRD_chr9_8733780_ENST00000356435_IDO1_chr8_39775394_ENST00000522495_length(amino acids)=377AA_BP=3
MLRENLPDFYNDWMFIAKHLPDLIESGQLRERVEKLNMLSIDHLTDHKSQRLARLVLGCITMAYVWGKGHGDVRKVLPRNIAVPYCQLSK
KLELPPILVYADCVLANWKKKDPNKPLTYENMDVLFSFRDGDCSKGFFLVSLLVEIAAASAIKVIPTVFKAMQMQERDTLLKALLEIASC
LEKALQVFHQIHDHVNPKAFFSVLRIYLSGWKGNPQLSDGLVYEGFWEDPKEFAGGSAGQSSVFQCFDVLLGIQQTAGGGHAAQFLQDMR
RYMPPAHRNFLCSLESNPSVREFVLSKGDAGLREAYDACVKALVSLRSYHLQIVTKYILIPASQQPKENKTSEDPSKLEAKGTGGTDLMN

--------------------------------------------------------------

>70349_70349_5_PTPRD-IDO1_PTPRD_chr9_8733780_ENST00000358503_IDO1_chr8_39775394_ENST00000518237_length(amino acids)=377AA_BP=3
MLRENLPDFYNDWMFIAKHLPDLIESGQLRERVEKLNMLSIDHLTDHKSQRLARLVLGCITMAYVWGKGHGDVRKVLPRNIAVPYCQLSK
KLELPPILVYADCVLANWKKKDPNKPLTYENMDVLFSFRDGDCSKGFFLVSLLVEIAAASAIKVIPTVFKAMQMQERDTLLKALLEIASC
LEKALQVFHQIHDHVNPKAFFSVLRIYLSGWKGNPQLSDGLVYEGFWEDPKEFAGGSAGQSSVFQCFDVLLGIQQTAGGGHAAQFLQDMR
RYMPPAHRNFLCSLESNPSVREFVLSKGDAGLREAYDACVKALVSLRSYHLQIVTKYILIPASQQPKENKTSEDPSKLEAKGTGGTDLMN

--------------------------------------------------------------

>70349_70349_6_PTPRD-IDO1_PTPRD_chr9_8733780_ENST00000358503_IDO1_chr8_39775394_ENST00000522495_length(amino acids)=377AA_BP=3
MLRENLPDFYNDWMFIAKHLPDLIESGQLRERVEKLNMLSIDHLTDHKSQRLARLVLGCITMAYVWGKGHGDVRKVLPRNIAVPYCQLSK
KLELPPILVYADCVLANWKKKDPNKPLTYENMDVLFSFRDGDCSKGFFLVSLLVEIAAASAIKVIPTVFKAMQMQERDTLLKALLEIASC
LEKALQVFHQIHDHVNPKAFFSVLRIYLSGWKGNPQLSDGLVYEGFWEDPKEFAGGSAGQSSVFQCFDVLLGIQQTAGGGHAAQFLQDMR
RYMPPAHRNFLCSLESNPSVREFVLSKGDAGLREAYDACVKALVSLRSYHLQIVTKYILIPASQQPKENKTSEDPSKLEAKGTGGTDLMN

--------------------------------------------------------------

>70349_70349_7_PTPRD-IDO1_PTPRD_chr9_8733780_ENST00000360074_IDO1_chr8_39775394_ENST00000518237_length(amino acids)=377AA_BP=3
MLRENLPDFYNDWMFIAKHLPDLIESGQLRERVEKLNMLSIDHLTDHKSQRLARLVLGCITMAYVWGKGHGDVRKVLPRNIAVPYCQLSK
KLELPPILVYADCVLANWKKKDPNKPLTYENMDVLFSFRDGDCSKGFFLVSLLVEIAAASAIKVIPTVFKAMQMQERDTLLKALLEIASC
LEKALQVFHQIHDHVNPKAFFSVLRIYLSGWKGNPQLSDGLVYEGFWEDPKEFAGGSAGQSSVFQCFDVLLGIQQTAGGGHAAQFLQDMR
RYMPPAHRNFLCSLESNPSVREFVLSKGDAGLREAYDACVKALVSLRSYHLQIVTKYILIPASQQPKENKTSEDPSKLEAKGTGGTDLMN

--------------------------------------------------------------

>70349_70349_8_PTPRD-IDO1_PTPRD_chr9_8733780_ENST00000360074_IDO1_chr8_39775394_ENST00000522495_length(amino acids)=377AA_BP=3
MLRENLPDFYNDWMFIAKHLPDLIESGQLRERVEKLNMLSIDHLTDHKSQRLARLVLGCITMAYVWGKGHGDVRKVLPRNIAVPYCQLSK
KLELPPILVYADCVLANWKKKDPNKPLTYENMDVLFSFRDGDCSKGFFLVSLLVEIAAASAIKVIPTVFKAMQMQERDTLLKALLEIASC
LEKALQVFHQIHDHVNPKAFFSVLRIYLSGWKGNPQLSDGLVYEGFWEDPKEFAGGSAGQSSVFQCFDVLLGIQQTAGGGHAAQFLQDMR
RYMPPAHRNFLCSLESNPSVREFVLSKGDAGLREAYDACVKALVSLRSYHLQIVTKYILIPASQQPKENKTSEDPSKLEAKGTGGTDLMN

--------------------------------------------------------------

>70349_70349_9_PTPRD-IDO1_PTPRD_chr9_8733780_ENST00000381196_IDO1_chr8_39775394_ENST00000518237_length(amino acids)=377AA_BP=3
MLRENLPDFYNDWMFIAKHLPDLIESGQLRERVEKLNMLSIDHLTDHKSQRLARLVLGCITMAYVWGKGHGDVRKVLPRNIAVPYCQLSK
KLELPPILVYADCVLANWKKKDPNKPLTYENMDVLFSFRDGDCSKGFFLVSLLVEIAAASAIKVIPTVFKAMQMQERDTLLKALLEIASC
LEKALQVFHQIHDHVNPKAFFSVLRIYLSGWKGNPQLSDGLVYEGFWEDPKEFAGGSAGQSSVFQCFDVLLGIQQTAGGGHAAQFLQDMR
RYMPPAHRNFLCSLESNPSVREFVLSKGDAGLREAYDACVKALVSLRSYHLQIVTKYILIPASQQPKENKTSEDPSKLEAKGTGGTDLMN

--------------------------------------------------------------

>70349_70349_10_PTPRD-IDO1_PTPRD_chr9_8733780_ENST00000381196_IDO1_chr8_39775394_ENST00000522495_length(amino acids)=377AA_BP=3
MLRENLPDFYNDWMFIAKHLPDLIESGQLRERVEKLNMLSIDHLTDHKSQRLARLVLGCITMAYVWGKGHGDVRKVLPRNIAVPYCQLSK
KLELPPILVYADCVLANWKKKDPNKPLTYENMDVLFSFRDGDCSKGFFLVSLLVEIAAASAIKVIPTVFKAMQMQERDTLLKALLEIASC
LEKALQVFHQIHDHVNPKAFFSVLRIYLSGWKGNPQLSDGLVYEGFWEDPKEFAGGSAGQSSVFQCFDVLLGIQQTAGGGHAAQFLQDMR
RYMPPAHRNFLCSLESNPSVREFVLSKGDAGLREAYDACVKALVSLRSYHLQIVTKYILIPASQQPKENKTSEDPSKLEAKGTGGTDLMN

--------------------------------------------------------------

>70349_70349_11_PTPRD-IDO1_PTPRD_chr9_8733780_ENST00000397606_IDO1_chr8_39775394_ENST00000518237_length(amino acids)=377AA_BP=3
MLRENLPDFYNDWMFIAKHLPDLIESGQLRERVEKLNMLSIDHLTDHKSQRLARLVLGCITMAYVWGKGHGDVRKVLPRNIAVPYCQLSK
KLELPPILVYADCVLANWKKKDPNKPLTYENMDVLFSFRDGDCSKGFFLVSLLVEIAAASAIKVIPTVFKAMQMQERDTLLKALLEIASC
LEKALQVFHQIHDHVNPKAFFSVLRIYLSGWKGNPQLSDGLVYEGFWEDPKEFAGGSAGQSSVFQCFDVLLGIQQTAGGGHAAQFLQDMR
RYMPPAHRNFLCSLESNPSVREFVLSKGDAGLREAYDACVKALVSLRSYHLQIVTKYILIPASQQPKENKTSEDPSKLEAKGTGGTDLMN

--------------------------------------------------------------

>70349_70349_12_PTPRD-IDO1_PTPRD_chr9_8733780_ENST00000397606_IDO1_chr8_39775394_ENST00000522495_length(amino acids)=377AA_BP=3
MLRENLPDFYNDWMFIAKHLPDLIESGQLRERVEKLNMLSIDHLTDHKSQRLARLVLGCITMAYVWGKGHGDVRKVLPRNIAVPYCQLSK
KLELPPILVYADCVLANWKKKDPNKPLTYENMDVLFSFRDGDCSKGFFLVSLLVEIAAASAIKVIPTVFKAMQMQERDTLLKALLEIASC
LEKALQVFHQIHDHVNPKAFFSVLRIYLSGWKGNPQLSDGLVYEGFWEDPKEFAGGSAGQSSVFQCFDVLLGIQQTAGGGHAAQFLQDMR
RYMPPAHRNFLCSLESNPSVREFVLSKGDAGLREAYDACVKALVSLRSYHLQIVTKYILIPASQQPKENKTSEDPSKLEAKGTGGTDLMN

--------------------------------------------------------------

>70349_70349_13_PTPRD-IDO1_PTPRD_chr9_8733780_ENST00000397611_IDO1_chr8_39775394_ENST00000518237_length(amino acids)=377AA_BP=3
MLRENLPDFYNDWMFIAKHLPDLIESGQLRERVEKLNMLSIDHLTDHKSQRLARLVLGCITMAYVWGKGHGDVRKVLPRNIAVPYCQLSK
KLELPPILVYADCVLANWKKKDPNKPLTYENMDVLFSFRDGDCSKGFFLVSLLVEIAAASAIKVIPTVFKAMQMQERDTLLKALLEIASC
LEKALQVFHQIHDHVNPKAFFSVLRIYLSGWKGNPQLSDGLVYEGFWEDPKEFAGGSAGQSSVFQCFDVLLGIQQTAGGGHAAQFLQDMR
RYMPPAHRNFLCSLESNPSVREFVLSKGDAGLREAYDACVKALVSLRSYHLQIVTKYILIPASQQPKENKTSEDPSKLEAKGTGGTDLMN

--------------------------------------------------------------

>70349_70349_14_PTPRD-IDO1_PTPRD_chr9_8733780_ENST00000397611_IDO1_chr8_39775394_ENST00000522495_length(amino acids)=377AA_BP=3
MLRENLPDFYNDWMFIAKHLPDLIESGQLRERVEKLNMLSIDHLTDHKSQRLARLVLGCITMAYVWGKGHGDVRKVLPRNIAVPYCQLSK
KLELPPILVYADCVLANWKKKDPNKPLTYENMDVLFSFRDGDCSKGFFLVSLLVEIAAASAIKVIPTVFKAMQMQERDTLLKALLEIASC
LEKALQVFHQIHDHVNPKAFFSVLRIYLSGWKGNPQLSDGLVYEGFWEDPKEFAGGSAGQSSVFQCFDVLLGIQQTAGGGHAAQFLQDMR
RYMPPAHRNFLCSLESNPSVREFVLSKGDAGLREAYDACVKALVSLRSYHLQIVTKYILIPASQQPKENKTSEDPSKLEAKGTGGTDLMN

--------------------------------------------------------------

>70349_70349_15_PTPRD-IDO1_PTPRD_chr9_8733780_ENST00000397617_IDO1_chr8_39775394_ENST00000518237_length(amino acids)=377AA_BP=3
MLRENLPDFYNDWMFIAKHLPDLIESGQLRERVEKLNMLSIDHLTDHKSQRLARLVLGCITMAYVWGKGHGDVRKVLPRNIAVPYCQLSK
KLELPPILVYADCVLANWKKKDPNKPLTYENMDVLFSFRDGDCSKGFFLVSLLVEIAAASAIKVIPTVFKAMQMQERDTLLKALLEIASC
LEKALQVFHQIHDHVNPKAFFSVLRIYLSGWKGNPQLSDGLVYEGFWEDPKEFAGGSAGQSSVFQCFDVLLGIQQTAGGGHAAQFLQDMR
RYMPPAHRNFLCSLESNPSVREFVLSKGDAGLREAYDACVKALVSLRSYHLQIVTKYILIPASQQPKENKTSEDPSKLEAKGTGGTDLMN

--------------------------------------------------------------

>70349_70349_16_PTPRD-IDO1_PTPRD_chr9_8733780_ENST00000397617_IDO1_chr8_39775394_ENST00000522495_length(amino acids)=377AA_BP=3
MLRENLPDFYNDWMFIAKHLPDLIESGQLRERVEKLNMLSIDHLTDHKSQRLARLVLGCITMAYVWGKGHGDVRKVLPRNIAVPYCQLSK
KLELPPILVYADCVLANWKKKDPNKPLTYENMDVLFSFRDGDCSKGFFLVSLLVEIAAASAIKVIPTVFKAMQMQERDTLLKALLEIASC
LEKALQVFHQIHDHVNPKAFFSVLRIYLSGWKGNPQLSDGLVYEGFWEDPKEFAGGSAGQSSVFQCFDVLLGIQQTAGGGHAAQFLQDMR
RYMPPAHRNFLCSLESNPSVREFVLSKGDAGLREAYDACVKALVSLRSYHLQIVTKYILIPASQQPKENKTSEDPSKLEAKGTGGTDLMN

--------------------------------------------------------------

>70349_70349_17_PTPRD-IDO1_PTPRD_chr9_8733780_ENST00000486161_IDO1_chr8_39775394_ENST00000518237_length(amino acids)=377AA_BP=3
MLRENLPDFYNDWMFIAKHLPDLIESGQLRERVEKLNMLSIDHLTDHKSQRLARLVLGCITMAYVWGKGHGDVRKVLPRNIAVPYCQLSK
KLELPPILVYADCVLANWKKKDPNKPLTYENMDVLFSFRDGDCSKGFFLVSLLVEIAAASAIKVIPTVFKAMQMQERDTLLKALLEIASC
LEKALQVFHQIHDHVNPKAFFSVLRIYLSGWKGNPQLSDGLVYEGFWEDPKEFAGGSAGQSSVFQCFDVLLGIQQTAGGGHAAQFLQDMR
RYMPPAHRNFLCSLESNPSVREFVLSKGDAGLREAYDACVKALVSLRSYHLQIVTKYILIPASQQPKENKTSEDPSKLEAKGTGGTDLMN

--------------------------------------------------------------

>70349_70349_18_PTPRD-IDO1_PTPRD_chr9_8733780_ENST00000486161_IDO1_chr8_39775394_ENST00000522495_length(amino acids)=377AA_BP=3
MLRENLPDFYNDWMFIAKHLPDLIESGQLRERVEKLNMLSIDHLTDHKSQRLARLVLGCITMAYVWGKGHGDVRKVLPRNIAVPYCQLSK
KLELPPILVYADCVLANWKKKDPNKPLTYENMDVLFSFRDGDCSKGFFLVSLLVEIAAASAIKVIPTVFKAMQMQERDTLLKALLEIASC
LEKALQVFHQIHDHVNPKAFFSVLRIYLSGWKGNPQLSDGLVYEGFWEDPKEFAGGSAGQSSVFQCFDVLLGIQQTAGGGHAAQFLQDMR
RYMPPAHRNFLCSLESNPSVREFVLSKGDAGLREAYDACVKALVSLRSYHLQIVTKYILIPASQQPKENKTSEDPSKLEAKGTGGTDLMN

--------------------------------------------------------------

>70349_70349_19_PTPRD-IDO1_PTPRD_chr9_8733780_ENST00000537002_IDO1_chr8_39775394_ENST00000518237_length(amino acids)=377AA_BP=3
MLRENLPDFYNDWMFIAKHLPDLIESGQLRERVEKLNMLSIDHLTDHKSQRLARLVLGCITMAYVWGKGHGDVRKVLPRNIAVPYCQLSK
KLELPPILVYADCVLANWKKKDPNKPLTYENMDVLFSFRDGDCSKGFFLVSLLVEIAAASAIKVIPTVFKAMQMQERDTLLKALLEIASC
LEKALQVFHQIHDHVNPKAFFSVLRIYLSGWKGNPQLSDGLVYEGFWEDPKEFAGGSAGQSSVFQCFDVLLGIQQTAGGGHAAQFLQDMR
RYMPPAHRNFLCSLESNPSVREFVLSKGDAGLREAYDACVKALVSLRSYHLQIVTKYILIPASQQPKENKTSEDPSKLEAKGTGGTDLMN

--------------------------------------------------------------

>70349_70349_20_PTPRD-IDO1_PTPRD_chr9_8733780_ENST00000537002_IDO1_chr8_39775394_ENST00000522495_length(amino acids)=377AA_BP=3
MLRENLPDFYNDWMFIAKHLPDLIESGQLRERVEKLNMLSIDHLTDHKSQRLARLVLGCITMAYVWGKGHGDVRKVLPRNIAVPYCQLSK
KLELPPILVYADCVLANWKKKDPNKPLTYENMDVLFSFRDGDCSKGFFLVSLLVEIAAASAIKVIPTVFKAMQMQERDTLLKALLEIASC
LEKALQVFHQIHDHVNPKAFFSVLRIYLSGWKGNPQLSDGLVYEGFWEDPKEFAGGSAGQSSVFQCFDVLLGIQQTAGGGHAAQFLQDMR
RYMPPAHRNFLCSLESNPSVREFVLSKGDAGLREAYDACVKALVSLRSYHLQIVTKYILIPASQQPKENKTSEDPSKLEAKGTGGTDLMN

--------------------------------------------------------------

>70349_70349_21_PTPRD-IDO1_PTPRD_chr9_8733780_ENST00000540109_IDO1_chr8_39775394_ENST00000518237_length(amino acids)=377AA_BP=3
MLRENLPDFYNDWMFIAKHLPDLIESGQLRERVEKLNMLSIDHLTDHKSQRLARLVLGCITMAYVWGKGHGDVRKVLPRNIAVPYCQLSK
KLELPPILVYADCVLANWKKKDPNKPLTYENMDVLFSFRDGDCSKGFFLVSLLVEIAAASAIKVIPTVFKAMQMQERDTLLKALLEIASC
LEKALQVFHQIHDHVNPKAFFSVLRIYLSGWKGNPQLSDGLVYEGFWEDPKEFAGGSAGQSSVFQCFDVLLGIQQTAGGGHAAQFLQDMR
RYMPPAHRNFLCSLESNPSVREFVLSKGDAGLREAYDACVKALVSLRSYHLQIVTKYILIPASQQPKENKTSEDPSKLEAKGTGGTDLMN

--------------------------------------------------------------

>70349_70349_22_PTPRD-IDO1_PTPRD_chr9_8733780_ENST00000540109_IDO1_chr8_39775394_ENST00000522495_length(amino acids)=377AA_BP=3
MLRENLPDFYNDWMFIAKHLPDLIESGQLRERVEKLNMLSIDHLTDHKSQRLARLVLGCITMAYVWGKGHGDVRKVLPRNIAVPYCQLSK
KLELPPILVYADCVLANWKKKDPNKPLTYENMDVLFSFRDGDCSKGFFLVSLLVEIAAASAIKVIPTVFKAMQMQERDTLLKALLEIASC
LEKALQVFHQIHDHVNPKAFFSVLRIYLSGWKGNPQLSDGLVYEGFWEDPKEFAGGSAGQSSVFQCFDVLLGIQQTAGGGHAAQFLQDMR
RYMPPAHRNFLCSLESNPSVREFVLSKGDAGLREAYDACVKALVSLRSYHLQIVTKYILIPASQQPKENKTSEDPSKLEAKGTGGTDLMN

--------------------------------------------------------------

Top

Fusion Protein Functional Features

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr9:8733780/chr8:39771408)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	IDO1 P14902
FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.	FUNCTION: Catalyzes the first and rate limiting step of the catabolism of the essential amino acid tryptophan along the kynurenine pathway (PubMed:17671174). Involved in the peripheral immune tolerance, contributing to maintain homeostasis by preventing autoimmunity or immunopathology that would result from uncontrolled and overreacting immune responses (PubMed:25691885). Tryptophan shortage inhibits T lymphocytes division and accumulation of tryptophan catabolites induces T-cell apoptosis and differentiation of regulatory T-cells (PubMed:25691885). Acts as a suppressor of anti-tumor immunity (PubMed:23103127, PubMed:25157255, PubMed:14502282, PubMed:25691885). Limits the growth of intracellular pathogens by depriving tryptophan (PubMed:25691885). Protects the fetus from maternal immune rejection (PubMed:25691885). {ECO:0000269\|PubMed:14502282, ECO:0000269\|PubMed:17671174, ECO:0000303\|PubMed:23103127, ECO:0000303\|PubMed:25157255, ECO:0000303\|PubMed:25691885}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
* Minus value of BPloci means that the break pointn is located before the CDS.

- Retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

- Not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

PTPRD

chr9:8733780

chr8:39775394

ENST00000355233

1020_1106

21.333333333333332

1507.0

Domain

Fibronectin type-III 8

Hgene

PTPRD

chr9:8733780

chr8:39775394

ENST00000355233

126_224

21.333333333333332

1507.0

Domain

Note=Ig-like C2-type 2

Hgene

PTPRD

chr9:8733780

chr8:39775394

ENST00000355233

1357_1612

21.333333333333332

1507.0

Domain

Tyrosine-protein phosphatase 1

Hgene

PTPRD

chr9:8733780

chr8:39775394

ENST00000355233

1644_1903

21.333333333333332

1507.0

Domain

Tyrosine-protein phosphatase 2

Hgene

PTPRD

chr9:8733780

chr8:39775394

ENST00000355233

236_318

21.333333333333332

1507.0

Domain

Note=Ig-like C2-type 3

Hgene

PTPRD

chr9:8733780

chr8:39775394

ENST00000355233

24_114

21.333333333333332

1507.0

Domain

Note=Ig-like C2-type 1

Hgene

PTPRD

chr9:8733780

chr8:39775394

ENST00000355233

325_415

21.333333333333332

1507.0

Domain

Fibronectin type-III 1

Hgene

PTPRD

chr9:8733780

chr8:39775394

ENST00000355233

420_516

21.333333333333332

1507.0

Domain

Fibronectin type-III 2

Hgene

PTPRD

chr9:8733780

chr8:39775394

ENST00000355233

518_607

21.333333333333332

1507.0

Domain

Fibronectin type-III 3

Hgene

PTPRD

chr9:8733780

chr8:39775394

ENST00000355233

612_709

21.333333333333332

1507.0

Domain

Fibronectin type-III 4

Hgene

PTPRD

chr9:8733780

chr8:39775394

ENST00000355233

714_822

21.333333333333332

1507.0

Domain

Fibronectin type-III 5

Hgene

PTPRD

chr9:8733780

chr8:39775394

ENST00000355233

823_916

21.333333333333332

1507.0

Domain

Fibronectin type-III 6

Hgene

PTPRD

chr9:8733780

chr8:39775394

ENST00000355233

921_1016

21.333333333333332

1507.0

Domain

Fibronectin type-III 7

Hgene

PTPRD

chr9:8733780

chr8:39775394

ENST00000356435

1020_1106

21.333333333333332

1913.0

Domain

Fibronectin type-III 8

Hgene

PTPRD

chr9:8733780

chr8:39775394

ENST00000356435

126_224

21.333333333333332

1913.0

Domain

Note=Ig-like C2-type 2

Hgene

PTPRD

chr9:8733780

chr8:39775394

ENST00000356435

1357_1612

21.333333333333332

1913.0

Domain

Tyrosine-protein phosphatase 1

Hgene

PTPRD

chr9:8733780

chr8:39775394

ENST00000356435

1644_1903

21.333333333333332

1913.0

Domain

Tyrosine-protein phosphatase 2

Hgene

PTPRD

chr9:8733780

chr8:39775394

ENST00000356435

236_318

21.333333333333332

1913.0

Domain

Note=Ig-like C2-type 3

Hgene

PTPRD

chr9:8733780

chr8:39775394

ENST00000356435

24_114

21.333333333333332

1913.0

Domain

Note=Ig-like C2-type 1

Hgene

PTPRD

chr9:8733780

chr8:39775394

ENST00000356435

325_415

21.333333333333332

1913.0

Domain

Fibronectin type-III 1

Hgene

PTPRD

chr9:8733780

chr8:39775394

ENST00000356435

420_516

21.333333333333332

1913.0

Domain

Fibronectin type-III 2

Hgene

PTPRD

chr9:8733780

chr8:39775394

ENST00000356435

518_607

21.333333333333332

1913.0

Domain

Fibronectin type-III 3

Hgene

PTPRD

chr9:8733780

chr8:39775394

ENST00000356435

612_709

21.333333333333332

1913.0

Domain

Fibronectin type-III 4

Hgene

PTPRD

chr9:8733780

chr8:39775394

ENST00000356435

714_822

21.333333333333332

1913.0

Domain

Fibronectin type-III 5

Hgene

PTPRD

chr9:8733780

chr8:39775394

ENST00000356435

823_916

21.333333333333332

1913.0

Domain

Fibronectin type-III 6

Hgene

PTPRD

chr9:8733780

chr8:39775394

ENST00000356435

921_1016

21.333333333333332

1913.0

Domain

Fibronectin type-III 7

Hgene

PTPRD

chr9:8733780

chr8:39775394

ENST00000381196

1020_1106

21.333333333333332

1913.0

Domain

Fibronectin type-III 8

Hgene

PTPRD

chr9:8733780

chr8:39775394

ENST00000381196

126_224

21.333333333333332

1913.0

Domain

Note=Ig-like C2-type 2

Hgene

PTPRD

chr9:8733780

chr8:39775394

ENST00000381196

1357_1612

21.333333333333332

1913.0

Domain

Tyrosine-protein phosphatase 1

Hgene

PTPRD

chr9:8733780

chr8:39775394

ENST00000381196

1644_1903

21.333333333333332

1913.0

Domain

Tyrosine-protein phosphatase 2

Hgene

PTPRD

chr9:8733780

chr8:39775394

ENST00000381196

236_318

21.333333333333332

1913.0

Domain

Note=Ig-like C2-type 3

Hgene

PTPRD

chr9:8733780

chr8:39775394

ENST00000381196

24_114

21.333333333333332

1913.0

Domain

Note=Ig-like C2-type 1

Hgene

PTPRD

chr9:8733780

chr8:39775394

ENST00000381196

325_415

21.333333333333332

1913.0

Domain

Fibronectin type-III 1

Hgene

PTPRD

chr9:8733780

chr8:39775394

ENST00000381196

420_516

21.333333333333332

1913.0

Domain

Fibronectin type-III 2

Hgene

PTPRD

chr9:8733780

chr8:39775394

ENST00000381196

518_607

21.333333333333332

1913.0

Domain

Fibronectin type-III 3

Hgene

PTPRD

chr9:8733780

chr8:39775394

ENST00000381196

612_709

21.333333333333332

1913.0

Domain

Fibronectin type-III 4

Hgene

PTPRD

chr9:8733780

chr8:39775394

ENST00000381196

714_822

21.333333333333332

1913.0

Domain

Fibronectin type-III 5

Hgene

PTPRD

chr9:8733780

chr8:39775394

ENST00000381196

823_916

21.333333333333332

1913.0

Domain

Fibronectin type-III 6

Hgene

PTPRD

chr9:8733780

chr8:39775394

ENST00000381196

921_1016

21.333333333333332

1913.0

Domain

Fibronectin type-III 7

Hgene

PTPRD

chr9:8733780

chr8:39775394

ENST00000397606

1020_1106

21.333333333333332

1506.0

Domain

Fibronectin type-III 8

Hgene

PTPRD

chr9:8733780

chr8:39775394

ENST00000397606

126_224

21.333333333333332

1506.0

Domain

Note=Ig-like C2-type 2

Hgene

PTPRD

chr9:8733780

chr8:39775394

ENST00000397606

1357_1612

21.333333333333332

1506.0

Domain

Tyrosine-protein phosphatase 1

Hgene

PTPRD

chr9:8733780

chr8:39775394

ENST00000397606

1644_1903

21.333333333333332

1506.0

Domain

Tyrosine-protein phosphatase 2

Hgene

PTPRD

chr9:8733780

chr8:39775394

ENST00000397606

236_318

21.333333333333332

1506.0

Domain

Note=Ig-like C2-type 3

Hgene

PTPRD

chr9:8733780

chr8:39775394

ENST00000397606

24_114

21.333333333333332

1506.0

Domain

Note=Ig-like C2-type 1

Hgene

PTPRD

chr9:8733780

chr8:39775394

ENST00000397606

325_415

21.333333333333332

1506.0

Domain

Fibronectin type-III 1

Hgene

PTPRD

chr9:8733780

chr8:39775394

ENST00000397606

420_516

21.333333333333332

1506.0

Domain

Fibronectin type-III 2

Hgene

PTPRD

chr9:8733780

chr8:39775394

ENST00000397606

518_607

21.333333333333332

1506.0

Domain

Fibronectin type-III 3

Hgene

PTPRD

chr9:8733780

chr8:39775394

ENST00000397606

612_709

21.333333333333332

1506.0

Domain

Fibronectin type-III 4

Hgene

PTPRD

chr9:8733780

chr8:39775394

ENST00000397606

714_822

21.333333333333332

1506.0

Domain

Fibronectin type-III 5

Hgene

PTPRD

chr9:8733780

chr8:39775394

ENST00000397606

823_916

21.333333333333332

1506.0

Domain

Fibronectin type-III 6

Hgene

PTPRD

chr9:8733780

chr8:39775394

ENST00000397606

921_1016

21.333333333333332

1506.0

Domain

Fibronectin type-III 7

Hgene

PTPRD

chr9:8733780

chr8:39775394

ENST00000486161

1020_1106

21.333333333333332

1506.0

Domain

Fibronectin type-III 8

Hgene

PTPRD

chr9:8733780

chr8:39775394

ENST00000486161

126_224

21.333333333333332

1506.0

Domain

Note=Ig-like C2-type 2

Hgene

PTPRD

chr9:8733780

chr8:39775394

ENST00000486161

1357_1612

21.333333333333332

1506.0

Domain

Tyrosine-protein phosphatase 1

Hgene

PTPRD

chr9:8733780

chr8:39775394

ENST00000486161

1644_1903

21.333333333333332

1506.0

Domain

Tyrosine-protein phosphatase 2

Hgene

PTPRD

chr9:8733780

chr8:39775394

ENST00000486161

236_318

21.333333333333332

1506.0

Domain

Note=Ig-like C2-type 3

Hgene

PTPRD

chr9:8733780

chr8:39775394

ENST00000486161

24_114

21.333333333333332

1506.0

Domain

Note=Ig-like C2-type 1

Hgene

PTPRD

chr9:8733780

chr8:39775394

ENST00000486161

325_415

21.333333333333332

1506.0

Domain

Fibronectin type-III 1

Hgene

PTPRD

chr9:8733780

chr8:39775394

ENST00000486161

420_516

21.333333333333332

1506.0

Domain

Fibronectin type-III 2

Hgene

PTPRD

chr9:8733780

chr8:39775394

ENST00000486161

518_607

21.333333333333332

1506.0

Domain

Fibronectin type-III 3

Hgene

PTPRD

chr9:8733780

chr8:39775394

ENST00000486161

612_709

21.333333333333332

1506.0

Domain

Fibronectin type-III 4

Hgene

PTPRD

chr9:8733780

chr8:39775394

ENST00000486161

714_822

21.333333333333332

1506.0

Domain

Fibronectin type-III 5

Hgene

PTPRD

chr9:8733780

chr8:39775394

ENST00000486161

823_916

21.333333333333332

1506.0

Domain

Fibronectin type-III 6

Hgene

PTPRD

chr9:8733780

chr8:39775394

ENST00000486161

921_1016

21.333333333333332

1506.0

Domain

Fibronectin type-III 7

Hgene

PTPRD

chr9:8733780

chr8:39775394

ENST00000540109

1020_1106

21.333333333333332

1952.3333333333333

Domain

Fibronectin type-III 8

Hgene

PTPRD

chr9:8733780

chr8:39775394

ENST00000540109

126_224

21.333333333333332

1952.3333333333333

Domain

Note=Ig-like C2-type 2

Hgene

PTPRD

chr9:8733780

chr8:39775394

ENST00000540109

1357_1612

21.333333333333332

1952.3333333333333

Domain

Tyrosine-protein phosphatase 1

Hgene

PTPRD

chr9:8733780

chr8:39775394

ENST00000540109

1644_1903

21.333333333333332

1952.3333333333333

Domain

Tyrosine-protein phosphatase 2

Hgene

PTPRD

chr9:8733780

chr8:39775394

ENST00000540109

236_318

21.333333333333332

1952.3333333333333

Domain

Note=Ig-like C2-type 3

Hgene

PTPRD

chr9:8733780

chr8:39775394

ENST00000540109

24_114

21.333333333333332

1952.3333333333333

Domain

Note=Ig-like C2-type 1

Hgene

PTPRD

chr9:8733780

chr8:39775394

ENST00000540109

325_415

21.333333333333332

1952.3333333333333

Domain

Fibronectin type-III 1

Hgene

PTPRD

chr9:8733780

chr8:39775394

ENST00000540109

420_516

21.333333333333332

1952.3333333333333

Domain

Fibronectin type-III 2

Hgene

PTPRD

chr9:8733780

chr8:39775394

ENST00000540109

518_607

21.333333333333332

1952.3333333333333

Domain

Fibronectin type-III 3

Hgene

PTPRD

chr9:8733780

chr8:39775394

ENST00000540109

612_709

21.333333333333332

1952.3333333333333

Domain

Fibronectin type-III 4

Hgene

PTPRD

chr9:8733780

chr8:39775394

ENST00000540109

714_822

21.333333333333332

1952.3333333333333

Domain

Fibronectin type-III 5

Hgene

PTPRD

chr9:8733780

chr8:39775394

ENST00000540109

823_916

21.333333333333332

1952.3333333333333

Domain

Fibronectin type-III 6

Hgene

PTPRD

chr9:8733780

chr8:39775394

ENST00000540109

921_1016

21.333333333333332

1952.3333333333333

Domain

Fibronectin type-III 7

Hgene

PTPRD

chr9:8733780

chr8:39775394

ENST00000355233

1553_1559

21.333333333333332

1507.0

Region

Substrate binding

Hgene

PTPRD

chr9:8733780

chr8:39775394

ENST00000356435

1553_1559

21.333333333333332

1913.0

Region

Substrate binding

Hgene

PTPRD

chr9:8733780

chr8:39775394

ENST00000381196

1553_1559

21.333333333333332

1913.0

Region

Substrate binding

Hgene

PTPRD

chr9:8733780

chr8:39775394

ENST00000397606

1553_1559

21.333333333333332

1506.0

Region

Substrate binding

Hgene

PTPRD

chr9:8733780

chr8:39775394

ENST00000486161

1553_1559

21.333333333333332

1506.0

Region

Substrate binding

Hgene

PTPRD

chr9:8733780

chr8:39775394

ENST00000540109

1553_1559

21.333333333333332

1952.3333333333333

Region

Substrate binding

Hgene

PTPRD

chr9:8733780

chr8:39775394

ENST00000355233

1291_1912

21.333333333333332

1507.0

Topological domain

Cytoplasmic

Hgene

PTPRD

chr9:8733780

chr8:39775394

ENST00000355233

21_1265

21.333333333333332

1507.0

Topological domain

Extracellular

Hgene

PTPRD

chr9:8733780

chr8:39775394

ENST00000356435

1291_1912

21.333333333333332

1913.0

Topological domain

Cytoplasmic

Hgene

PTPRD

chr9:8733780

chr8:39775394

ENST00000356435

21_1265

21.333333333333332

1913.0

Topological domain

Extracellular

Hgene

PTPRD

chr9:8733780

chr8:39775394

ENST00000381196

1291_1912

21.333333333333332

1913.0

Topological domain

Cytoplasmic

Hgene

PTPRD

chr9:8733780

chr8:39775394

ENST00000381196

21_1265

21.333333333333332

1913.0

Topological domain

Extracellular

Hgene

PTPRD

chr9:8733780

chr8:39775394

ENST00000397606

1291_1912

21.333333333333332

1506.0

Topological domain

Cytoplasmic

Hgene

PTPRD

chr9:8733780

chr8:39775394

ENST00000397606

21_1265

21.333333333333332

1506.0

Topological domain

Extracellular

Hgene

PTPRD

chr9:8733780

chr8:39775394

ENST00000486161

1291_1912

21.333333333333332

1506.0

Topological domain

Cytoplasmic

Hgene

PTPRD

chr9:8733780

chr8:39775394

ENST00000486161

21_1265

21.333333333333332

1506.0

Topological domain

Extracellular

Hgene

PTPRD

chr9:8733780

chr8:39775394

ENST00000540109

1291_1912

21.333333333333332

1952.3333333333333

Topological domain

Cytoplasmic

Hgene

PTPRD

chr9:8733780

chr8:39775394

ENST00000540109

21_1265

21.333333333333332

1952.3333333333333

Topological domain

Extracellular

Hgene

PTPRD

chr9:8733780

chr8:39775394

ENST00000355233

1266_1290

21.333333333333332

1507.0

Transmembrane

Helical

Hgene

PTPRD

chr9:8733780

chr8:39775394

ENST00000356435

1266_1290

21.333333333333332

1913.0

Transmembrane

Helical

Hgene

PTPRD

chr9:8733780

chr8:39775394

ENST00000381196

1266_1290

21.333333333333332

1913.0

Transmembrane

Helical

Hgene

PTPRD

chr9:8733780

chr8:39775394

ENST00000397606

1266_1290

21.333333333333332

1506.0

Transmembrane

Helical

Hgene

PTPRD

chr9:8733780

chr8:39775394

ENST00000486161

1266_1290

21.333333333333332

1506.0

Transmembrane

Helical

Hgene

PTPRD

chr9:8733780

chr8:39775394

ENST00000540109

1266_1290

21.333333333333332

1952.3333333333333

Transmembrane

Helical

Top

Fusion Protein-Protein Interaction

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)

Gene

PPI interactors

Protein-protein interactors based on sequence similarity (STRING)

Gene	STRING network
PTPRD
IDO1

- Retained interactions in fusion protein (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost interactions due to fusion (protein functional feature from UniProt).

Partner	Gene	Hbp	Tbp	ENST	Strand	BPexon	TotalExon	Protein feature loci	*BPloci	TotalLen	Interaction lost with
Hgene	PTPRD	chr9:8733780	chr8:39775394	ENST00000355233	-	1	31	180_189	21.333333333333332	1507.0	IL1RAPL1
Hgene	PTPRD	chr9:8733780	chr8:39775394	ENST00000356435	-	1	35	180_189	21.333333333333332	1913.0	IL1RAPL1
Hgene	PTPRD	chr9:8733780	chr8:39775394	ENST00000381196	-	9	43	180_189	21.333333333333332	1913.0	IL1RAPL1
Hgene	PTPRD	chr9:8733780	chr8:39775394	ENST00000397606	-	1	29	180_189	21.333333333333332	1506.0	IL1RAPL1
Hgene	PTPRD	chr9:8733780	chr8:39775394	ENST00000486161	-	1	31	180_189	21.333333333333332	1506.0	IL1RAPL1
Hgene	PTPRD	chr9:8733780	chr8:39775394	ENST00000540109	-	1	36	180_189	21.333333333333332	1952.3333333333333	IL1RAPL1

Top

Related Drugs to PTPRD-IDO1

Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Drug

Source

PMID

Top

Related Diseases to PTPRD-IDO1

Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Disease

Source

PMID

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source